Basse Health and Demographic Surveillance System

Lead Research Organisation: MRC Unit, The Gambia

Abstract

By virtue of the size of the population it covers, the Basse HDSS offers opportunities to understand the dynamics and risk factors associated with common infectious diseases prevailing in a typical Sub-Saharan African setting characterised by poverty and limited access to health care facilities and services. Prospective follow up of the population through 4-monthly household demographic (and biennial socio-economic) updates determines the trends in the death rate in different age groups of the population; and the conduct of verbal autopsies for as many deaths as possible ascertains the probable causes of death. The process therefore enhances our understanding of the health and socio-economic factors that that drive and sustain the determinants of disease-specific morbid episodes and mortality, especially infectious diseases among children.

Technical Summary

The Basse Health and Demographic Surveillance System (BHDSS) was established in July 2007, primarily to support Basse’s participation in the Global Enteric Multicentre Study (GEMS) and the ongoing Pneumococcal Surveillance Project (PSP). It covers a population of about 170,000 in 219 settlements in the Fulladu East and Kantora Districts of the Upper River Region of The Gambia, a setting typical of much of rural Sub-Saharan and with a high burden of communicable and preventable diseases. In addition to the GEMS and PSP projects, it hosts and facilitates the implementation of a range of other projects and studies.
The BHDSS, with a similar operational design as the Farafenni HDSS, constitutes a potential valuable resource to establish benchmarks and monitor progress towards the achievement of post-2015 global and regional health indicators that the international community will be expected to set.
Specific strategies to be adopted to maximise the scientific output of the BHDSS include:
• Potential linkage of DSS data with Basse Major Health Centre records (in recognition of its potential upgrading to a District Hospital), thus broadening the scope for medical research to include, among other things, disease-specific morbidity burden estimation for both communicable and non-communicable diseases, and their respective impact on quality of life.
• Enhance capacity to support the placement of PhD students in the fields of Demography, Epidemiology, Sociology, etc, and build multi-disciplinary capacity for optimal utilisation of the data generated by the platform.
• Fully engage government stakeholders in the utilisation of the platform database to inform public health policy formulation and review; as well as generating the necessary evidence base required to guide rational health care delivery planning and resource allocation.

Publications

10 25 50

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Hossain MJ (2013) Serogroup W135 meningococcal disease, The Gambia, 2012. in Emerging infectious diseases

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Hossain MJ (2019) Cryptosporidium infection in rural Gambian children: Epidemiology and risk factors. in PLoS neglected tropical diseases

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Kwambana BA (2014) High genotypic diversity among rotavirus strains infecting Gambian children. in The Pediatric infectious disease journal

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Saha D (2013) Health Care Utilization and Attitudes Survey: understanding diarrheal disease in rural Gambia. in The American journal of tropical medicine and hygiene

 
Description African Population Cohorts Consortium (APCC) 
Organisation African Academy of Sciences
Country Kenya 
Sector Charity/Non Profit 
PI Contribution I was among a few senior African scientists/leaders selected to chair and lead discussions in a scoping workshop/meeting to agree and shape a vision for a multinational network of large cohorts. The purpose is to set up the African Population Cohorts Consortium (APCC) with a view to responding to the dearth of health and social data, which is hampering progress in addressing the increasing burden of non-communicable diseases along the high levels of infectious diseases and malnutrition in the continent. I chaired all sessions relating to Demography and Epi-demographic core metrics. I was also selected in a team tasked to develop a white paper through a series of post-workshop consultations for consideration by the interested funders..
Collaborator Contribution Through the Wellcome Trust, the team of funders organised and brought together experts working in the African continent for the scoping workshop. WT also coordinated the preparation of the white paper.
Impact The White Paper is yet to be published.
Start Year 2020
 
Description African Population Cohorts Consortium (APCC) 
Organisation Bill and Melinda Gates Foundation
Country United States 
Sector Charity/Non Profit 
PI Contribution I was among a few senior African scientists/leaders selected to chair and lead discussions in a scoping workshop/meeting to agree and shape a vision for a multinational network of large cohorts. The purpose is to set up the African Population Cohorts Consortium (APCC) with a view to responding to the dearth of health and social data, which is hampering progress in addressing the increasing burden of non-communicable diseases along the high levels of infectious diseases and malnutrition in the continent. I chaired all sessions relating to Demography and Epi-demographic core metrics. I was also selected in a team tasked to develop a white paper through a series of post-workshop consultations for consideration by the interested funders..
Collaborator Contribution Through the Wellcome Trust, the team of funders organised and brought together experts working in the African continent for the scoping workshop. WT also coordinated the preparation of the white paper.
Impact The White Paper is yet to be published.
Start Year 2020
 
Description African Population Cohorts Consortium (APCC) 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Public 
PI Contribution I was among a few senior African scientists/leaders selected to chair and lead discussions in a scoping workshop/meeting to agree and shape a vision for a multinational network of large cohorts. The purpose is to set up the African Population Cohorts Consortium (APCC) with a view to responding to the dearth of health and social data, which is hampering progress in addressing the increasing burden of non-communicable diseases along the high levels of infectious diseases and malnutrition in the continent. I chaired all sessions relating to Demography and Epi-demographic core metrics. I was also selected in a team tasked to develop a white paper through a series of post-workshop consultations for consideration by the interested funders..
Collaborator Contribution Through the Wellcome Trust, the team of funders organised and brought together experts working in the African continent for the scoping workshop. WT also coordinated the preparation of the white paper.
Impact The White Paper is yet to be published.
Start Year 2020
 
Description African Population Cohorts Consortium (APCC) 
Organisation Medical Research Council of South Africa (MRC)
Country South Africa 
Sector Public 
PI Contribution I was among a few senior African scientists/leaders selected to chair and lead discussions in a scoping workshop/meeting to agree and shape a vision for a multinational network of large cohorts. The purpose is to set up the African Population Cohorts Consortium (APCC) with a view to responding to the dearth of health and social data, which is hampering progress in addressing the increasing burden of non-communicable diseases along the high levels of infectious diseases and malnutrition in the continent. I chaired all sessions relating to Demography and Epi-demographic core metrics. I was also selected in a team tasked to develop a white paper through a series of post-workshop consultations for consideration by the interested funders..
Collaborator Contribution Through the Wellcome Trust, the team of funders organised and brought together experts working in the African continent for the scoping workshop. WT also coordinated the preparation of the white paper.
Impact The White Paper is yet to be published.
Start Year 2020
 
Description African Population Cohorts Consortium (APCC) 
Organisation National Institute of Allergy and Infectious Diseases (NIAID)
Country United States 
Sector Public 
PI Contribution I was among a few senior African scientists/leaders selected to chair and lead discussions in a scoping workshop/meeting to agree and shape a vision for a multinational network of large cohorts. The purpose is to set up the African Population Cohorts Consortium (APCC) with a view to responding to the dearth of health and social data, which is hampering progress in addressing the increasing burden of non-communicable diseases along the high levels of infectious diseases and malnutrition in the continent. I chaired all sessions relating to Demography and Epi-demographic core metrics. I was also selected in a team tasked to develop a white paper through a series of post-workshop consultations for consideration by the interested funders..
Collaborator Contribution Through the Wellcome Trust, the team of funders organised and brought together experts working in the African continent for the scoping workshop. WT also coordinated the preparation of the white paper.
Impact The White Paper is yet to be published.
Start Year 2020
 
Description African Population Cohorts Consortium (APCC) 
Organisation Wellcome Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution I was among a few senior African scientists/leaders selected to chair and lead discussions in a scoping workshop/meeting to agree and shape a vision for a multinational network of large cohorts. The purpose is to set up the African Population Cohorts Consortium (APCC) with a view to responding to the dearth of health and social data, which is hampering progress in addressing the increasing burden of non-communicable diseases along the high levels of infectious diseases and malnutrition in the continent. I chaired all sessions relating to Demography and Epi-demographic core metrics. I was also selected in a team tasked to develop a white paper through a series of post-workshop consultations for consideration by the interested funders..
Collaborator Contribution Through the Wellcome Trust, the team of funders organised and brought together experts working in the African continent for the scoping workshop. WT also coordinated the preparation of the white paper.
Impact The White Paper is yet to be published.
Start Year 2020
 
Description Cause of Death Determination 
Organisation International Network for the Demographic Evaluation of Populations and Their Health (INDEPTH)
Country Ghana 
Sector Charity/Non Profit 
PI Contribution Contribute Farafenni cause-of-death data for multi-site studies. Co-ordinated the analysis of HIV-attributable mortality in adults in four West African HDSS sites using verbal autopsy data.
Collaborator Contribution Development of a computer algorithm (InterVA) to interpret verbal autopsies. Development of standard verbal autopsy questionnaires.
Impact International seminar presentations.
Start Year 2011
 
Description Cause of Death Determination 
Organisation World Health Organization (WHO)
Department Health Metrics Network (HMN)
Country Switzerland 
Sector Charity/Non Profit 
PI Contribution Contribute Farafenni cause-of-death data for multi-site studies. Co-ordinated the analysis of HIV-attributable mortality in adults in four West African HDSS sites using verbal autopsy data.
Collaborator Contribution Development of a computer algorithm (InterVA) to interpret verbal autopsies. Development of standard verbal autopsy questionnaires.
Impact International seminar presentations.
Start Year 2011
 
Description Rationale for a Vaccine efficacy trial during Public Health Emergencies 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Participation in a series of meetings aimed at developing a clinical toolbox for vaccine trials during public health emergencies. Oral presentation at a joint WHO & NIAID (USA) Scientific Consultation on Zika Virus Vaccine Development, explaining the process adopted to develop the WHO R&D blueprint for action to prevent epidemics.
Collaborator Contribution Facilitation of my participation in all meetings and consultations.
Impact Work is still progressing on the WHO R&D blueprint for action to prevent epidemics.
Start Year 2016
 
Description WHO Ad Hoc Expert consultation on Non-Specific Effects of Vaccines 
Organisation World Health Organization (WHO)
Department Department of Immunization, Vaccines and Biologicals
Country Global 
Sector Public 
PI Contribution Participation in a series of workshops to develop a multi-site research protocol to investigate the impact of BCG on survival in the first 14 weeks of life, as well as in infancy. The Basse Health and Demographic Surveillance System is being put forward for consideration as a potential study site.
Collaborator Contribution Cover travel and board for all meetings I have attended.
Impact Draft research protocol on randomized controlled trials of early versus late BCG vaccination. It is yet to be finalised and submitted to the WHO SAGE advisory committee for consideration and approval.
Start Year 2016