Mary Lyon Centre Community Programmes - Genome Editing Mice for Medicine and the National Archive

Lead Research Organisation: MRC Harwell Institute

Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The objectives of the Genome Editing Mice for Medicine programme are to create novel mouse lines for preclinical studies and to refine and improve existing models. To this end, the UK academic research community is invited to nominate mouse lines for production using CRISPR/Cas9 technologies, which are reviewed by an expert panel for their value to research hypotheses or clinical diagnosis and their impact and utility for the wider research community.
The Mary Lyon Centre is the UK node of the European Mouse Mutant Archive (EMMA). The National Archive at Harwell is supported by extensive IT infrastructure and strain curation services, which greatly facilitates access to mouse lines, cryopreservation, import and rederivation services for UK scientists.

Total Expenditure April 2006 - March 2023:

£3,403,200

Funded Period:

Apr 22 - Mar 27

Funder:

MRC

Project Status:

Active

Project Category:

Intramural

Project Reference:

MC_UP_2201/2

Health Category:

Unclassified

Organisations

MRC Harwell Institute (Lead Research Organisation)

People

ORCID iD

Publications

Author Name

Title Publication Date Published

10 25 50

Devoy A (2022) Erratum: Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. in iScience

Fray M (2022) Cryogenics - Fundamentals, foundations and applications

Related Projects

Project Reference	Relationship	Related To	Start	End	Award Value
MC_UP_2201/1			01/04/2022	31/03/2027	£29,145,137
MC_UP_2201/2	Transfer	MC_UP_2201/1	01/04/2022	31/03/2027	£3,403,200
MC_UP_2201/3	Transfer	MC_UP_2201/2	01/04/2022	31/03/2027	£2,116,432

Research Tools and Methods


Title	10 x shipments of strains expressing Cre recombinase under control of ERT2
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	12 x shipments of strains carrying conditional allele
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	2 x import shipments -Cys421Ser/Cys424Ser RSK1
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	2 x shipments sent out - C57BL/6J-Acan/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	2 x shipments sent out - C57BL/6J-Htra1/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	27 x shipment of strains carrying an IKMC knockout-first allele
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	3 x shipments sent out - CD1; B6D2-Tg(Prm1-EGFP)#Ltku/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	5 x import shipments of wildtype mice
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	AhCre
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Mouse models
URL	https://archive.har.mrc.ac.uk/index


Title	AppKI(AppNL.G.F) x C57BL/6J.129P2-Dp(16Mis18a-Runx1)2TybEmcf
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	Atp2b2/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	B6(Cg)-Chd8^tm1.2Mabn/H
Description	Mouse Models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6-Cg-Sdhb/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6.129-S100A10^tm1Jnw/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6.Cg-Ddx5 Gt(ROSA)26Sor/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6.Cg-Ndrg1/H
Description	Mouse model
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6;129P2-Anxa6/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6;129P2-Gt(ROSA)26Sor/JknH
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6;129X1-ChmH
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6;CBACa-Tg(PMP22)C22Clh/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6J.129-Siglec1/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	B6J
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	B6J
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	B6JFVBF1-3p del
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C17S PKA RIa
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C195S PKG
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C230A EPHX 2
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C3H.Cg-Ankrd11/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	C3H/HeH-Pkhd1/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	C3H101H-Pax3/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6-Gt(ROSA)26Sor/GanlH
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6-SpastinN384K knock-in
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6-Tg(Cdh5-cre/ERT2)1Rha
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6-Zfp382/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6J-App/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6J-Cx3cr1/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6J-Rock1/SkmpH
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6J-Tg(Bmx-cre/ERT2)1Rha
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2023
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6J-Zfp667/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6J.129P2-Dp(16Lipi-Hunk)9TybEmcf/TybH
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6NTac-Cx3cl1/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	C57BL/6NTac-Grb10^em1H/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2021
Provided To Others?	Yes
Impact	Facilities Research - Export
URL	https://archive.har.mrc.ac.uk/index


Title	Cys42Ser PKG1a
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - non-mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Cys436Ser/Cys439Ser RSK2
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Cys564Gly Rsk1
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Del(10Map3k5-Map7)2Kcl/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Espn/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Gt(ROSA)26Sor/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	H11tm1(Cag mCherry, Top1g1)Jtu
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Hprt
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Hprttm1(CAG-mCherry Top1)Jtu
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	MPC1 tetO KI
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	MPC2 tetO KI
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	MRP-14 (S100a9 - /-)
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	PLP-GalNAc T-CFP
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Pcdh15/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Pten-R173C
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Publication of a research article relating to the IL19-/- mouse model
Description	Publication of article "IL-24 intrinsically regulates Th17 cell pathogenicity in mice" in the Journal of Experimental Medicine, describing the use of Il19-/- (C57BL/6N-Il19tm2e(EUCOMM)Hmgu/H) mice, which were sourced from the Mary Lyon Centre at MRC Harwell.
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community.
URL	https://rupress.org/jem/article-pdf/219/8/e20212443/1435623/jem_20212443.pdf


Title	STOCK Adcy1tm1Ljm/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import


Title	STOCK Igf2^tm4Wrk/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	STOCK Lhx1/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	T178A PKGI
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Tbx1/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Tbx5 K339R cKI/H
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Thy1-GalNAc T-CFP
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Trib1 Rosa TG (Gt(ROSA)26Sor) x Lyz2Cre-deleter
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Mouse models
URL	https://archive.har.mrc.ac.uk/index


Title	Utytm1(Flag-Cas9-EGFP)jtu
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Zfp189
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Zfp248
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Zfp263
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index


Title	Zfp263
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Mouse models
URL	https://archive.har.mrc.ac.uk/index


Title	Zik1
Description	Mouse models
Type Of Material	Model of mechanisms or symptoms - mammalian in vivo
Year Produced	2022
Provided To Others?	Yes
Impact	Facilities Research - Import
URL	https://archive.har.mrc.ac.uk/index