The role of ubiquitin and ubiquitin-like proteins during viral infection and host-cell immunity
Lead Research Organisation:
MRC Virology Unit
Abstract
During infection viruses must evade multiple host defence mechanisms in order to establish a productive infection. These include antibody and cell mediated acquired immunity, interferon regulated innate immunity, and intrinsic cellular immunity. In order to counteract these host defences many viruses have evolved strategies to engage with cellular ubiquitin and ubiquitin-like modification pathways to modulate their intracellular environment in favour of viral replication. This programme of research aims to define how specific viruses engage with components of these pathways in order to design and develop alternative therapeutic intervention strategies.
Our research has identified unique aspects relating to cellular immune defence and associated viral counter measures. Our current work aims to determine whether these pathways affect other clinically important human viruses, and to establish a platform of biochemical techniques that will facilitate the screening of compounds to inhibit viral counter measures of these pathways.
Our research has identified unique aspects relating to cellular immune defence and associated viral counter measures. Our current work aims to determine whether these pathways affect other clinically important human viruses, and to establish a platform of biochemical techniques that will facilitate the screening of compounds to inhibit viral counter measures of these pathways.
Technical Summary
The post-translational modification of proteins by ubiquitin and ubiquitin-related polypeptides regulates many essential cellular processes including protein degradation, transcription, DNA repair and host-cell anti-viral immunity. Consequently, many human viruses have evolved strategies to utilise or suppress these modification pathways in order to enhance their replication, thereby maintaining their presence within the human population. Utilising a variety of techniques; library screening, lentiviral expression, RNAi technologies, in vitro biochemistry and mass spectrometry, the aim of this programme is to identify and biochemically define how human viruses engage with components of these pathways during infection with respect to disarming host-cell anti-viral immunity. This work will provide a platform of biochemistry in order to develop novel strategies for future therapeutic intervention. The lab focuses on three clinically important human viruses: Herpes Simplex virus type-1 (HSV-1), Influenza A virus, and Hepatitis C Virus (HCV).
HSV-1 causes a variety of clinically important diseases, including herpes keratitis and encephalitis, and provides an ideal model system for studying multiple aspects of intracellular immunity in response to DNA virus infection. An important regulator of HSV-1 infection is ICP0, a viral ubiquitin ligase that targets a subset of cellular proteins implicated in anti-viral immune defecne for ubiquitination and proteasome-dependent degradation. Our research aims to identify and characterise the cellular regulators associated with nuclear immunity in response to DNA virus infection, both at a molecular and biochemical level, by virtue of identifying ICP0’s cellular substrates and biochemical specificity.
Recent progress in our understanding of the molecular mechanisms associated with the regulation of intrinsic immunity in response to HSV-1 infection are also being investigated in during the nuclear replication of RNA viruses, specifically Influenza A virus, in order to determine the specificity of these host defence mechanisms. Influenza virus infection is the leading causative agent associated with acute viral respiratory illnesses and causes significant annual morbidity and mortality within humans.
HCV infection is a leading cause of non-alcohol related liver disease within the UK, including decompensated cirrhosis and hepatocellular carcinoma. HCV induces the re-distribution of intracellular ubiquitin conjugates during infection, a phenotype that is dependent upon viral RNA replication. However, little is known about how HCV engages with components of the ubiquitin-pathway or the functional importance of these interactions with respect to viral replication. This research aims to identify and characterise the role of ubiquitin and ubiquitin-like modifications during HCV infection and their relationship to anti-viral defence.
HSV-1 causes a variety of clinically important diseases, including herpes keratitis and encephalitis, and provides an ideal model system for studying multiple aspects of intracellular immunity in response to DNA virus infection. An important regulator of HSV-1 infection is ICP0, a viral ubiquitin ligase that targets a subset of cellular proteins implicated in anti-viral immune defecne for ubiquitination and proteasome-dependent degradation. Our research aims to identify and characterise the cellular regulators associated with nuclear immunity in response to DNA virus infection, both at a molecular and biochemical level, by virtue of identifying ICP0’s cellular substrates and biochemical specificity.
Recent progress in our understanding of the molecular mechanisms associated with the regulation of intrinsic immunity in response to HSV-1 infection are also being investigated in during the nuclear replication of RNA viruses, specifically Influenza A virus, in order to determine the specificity of these host defence mechanisms. Influenza virus infection is the leading causative agent associated with acute viral respiratory illnesses and causes significant annual morbidity and mortality within humans.
HCV infection is a leading cause of non-alcohol related liver disease within the UK, including decompensated cirrhosis and hepatocellular carcinoma. HCV induces the re-distribution of intracellular ubiquitin conjugates during infection, a phenotype that is dependent upon viral RNA replication. However, little is known about how HCV engages with components of the ubiquitin-pathway or the functional importance of these interactions with respect to viral replication. This research aims to identify and characterise the role of ubiquitin and ubiquitin-like modifications during HCV infection and their relationship to anti-viral defence.
Organisations
- MRC Virology Unit, United Kingdom (Lead Research Organisation)
- The Pirbright Institute, WOKING (Collaboration)
- National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- York University Canada, Canada (Collaboration)
People |
ORCID iD |
Chris Boutell (Principal Investigator) |
Publications

Alandijany T
(2018)
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
in PLoS pathogens

Boutell C
(2011)
A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence.
in PLoS pathogens

Boutell C
(2013)
Regulation of alphaherpesvirus infections by the ICP0 family of proteins.
in The Journal of general virology

Boutell C
(2015)
A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro.
in Methods (San Diego, Calif.)


Busnadiego I
(2014)
Host and viral determinants of Mx2 antiretroviral activity.
in Journal of virology

Chaurushiya MS
(2012)
Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain.
in Molecular cell


Cuchet-Lourenço D
(2011)
SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes.
in PLoS pathogens

Domingues P
(2015)
Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase
in Journal of General Virology
Title | in vitro SUMO biochemistry update |
Description | The cloning, expression, and purification of various proteins implicated in the regulation of host SUMOylation. |
Type Of Material | Model of mechanisms or symptoms - in vitro |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, et al. Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Journal of virology. 2016;90(9):4807-26. doi: Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, et al. SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Journal of virology. 2016;90(13):5939-52. doi: 10.1128/JVI.00426-16. PubMed PMID: 27099310; PubMed Central PMCID: PMCPMC4907222. |
Title | in vitro ubiquitin biochemsitry updated |
Description | The cloning, expression, and purification of various proteins implicated in ubiquitin biochemistry. |
Type Of Material | Model of mechanisms or symptoms - in vitro |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | 1. Lilley, C. E., M. S. Chaurushiya, C. Boutell, S. Landry, J. Suh, S. Panier, R. D. Everett, G. S. Stewart, D. Durocher, and M. D. Weitzman. 2010. A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. Embo J 29:943-55. 2. Morris, J. R., C. Boutell, M. Keppler, R. Densham, D. Weekes, A. Alamshah, L. Butler, Y. Galanty, L. Pangon, T. Kiuchi, T. Ng, and E. Solomon. 2009. The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature 462:886-90. 3. Morris, J. R., L. Pangon, C. Boutell, T. Katagiri, N. H. Keep, and E. Solomon. 2006. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. Hum Mol Genet 15:599-606. |
Title | shRNA lentiviral cell lines updated 2016 |
Description | Primary cell lines that have been transduced with lentiviral vectors expressing short hairpin RNAs (shRNAs) to deplete components of the ubiquitin and SUMO conjugation pathways. |
Type Of Material | Cell line |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | Research ongoing. Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, et al. Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Journal of virology. 2016;90(9):4807-26. doi: Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, et al. SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Journal of virology. 2016;90(13):5939-52. doi: 10.1128/JVI.00426-16. PubMed PMID: 27099310; PubMed Central PMCID: PMCPMC4907222. |
Description | Cellular restriction of Influenza virus |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision of reagents to study SUMOylation and ubiquitination during Influenza virus infection |
Collaborator Contribution | Provision of reagents and expert knowledge within this area of research |
Impact | multi-disciplinary virology research |
Start Year | 2012 |
Description | Defining the role of SUMOylation during arbovirus infection |
Organisation | The Pirbright Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Defining the biochemical activity of host SUMOylation enzymes expressed in Aedes aegepti. |
Collaborator Contribution | Cloning of cDNAs that express Aedes aegepti SUMOylation enzymes |
Impact | Research ongoing. Student selected for national presentation (microbiology society) |
Start Year | 2014 |
Description | Intrinsic immunity to Influenza A Virus |
Organisation | University of Glasgow |
Department | MRC - University of Glasgow Centre for Virus Research |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provision or reagents and research support to establish a role for intrinsic immunity against IAV. |
Collaborator Contribution | Provision or reagents and research support to establish a role for intrinsic immunity against IAV. |
Impact | We have identfied the TRIM protein 22 to play a role in the cellular restriction of IAV prior to the activation of innate immune signalling, thereby confirming a role for intrinsic immunity in the intracellular restriction of IAV. A manuscript is currently in preparation. |
Start Year | 2015 |
Description | SUMO modification and centromeres |
Organisation | National Center for Scientific Research (Centre National de la Recherche Scientifique CNRS) |
Department | Center for Molecular Genetics (CGM) |
Country | France |
Sector | Academic/University |
PI Contribution | biochemical analysis |
Collaborator Contribution | Cell biology analysis |
Impact | Cell biology Ubiquitin SUMOylation Biochemistry |
Start Year | 2012 |
Description | X-ray crystallography studies of the purified ICP0 RING-finger domains from HSV-1 and VZV |
Organisation | York University Toronto |
Country | Canada |
Sector | Academic/University |
PI Contribution | Provision of reagents for the purification of RING-domain containing viral E3 ubiquitin ligases expressed during HSV-1 and VZV infection |
Collaborator Contribution | Purification of recombinant proteins and X-ray crystallography trials |
Impact | none |
Start Year | 2015 |
Description | 24th Annual Glasgow Virology Workshop June 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The CVR hosted the 24th Glasgow Virology Workshop (GVW) on Friday VV June 2019 (Sir Charles Wilson Building, University of Glasgow). This annual one-day meeting aims to communicate the latest innovative science in the world of virology, and to promote interactions between scientists and a variety of stakeholders throughout the world. This meeting is an informal and welcoming one day event comprising a mix of presentations from both external and internal speakers, along with networking sessions. It is rounded off by an evening ceilidh to provide attendees with a more relaxed opportunity to engage with one another. The annual event attracts a wide age range of attendees (from undergraduate students through to healthcare professionals, members of the biotech industry to retired professors), providing an ideal opportunity to catch up with former colleagues, establish new collaborations, and listen to truly inspirational science. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.facebook.com/centreforvirusresearch/ |
Description | Annual PCR Workshops September 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Each year the CVR runs a series of 6 individual workshops for Higher Biology school pupils. Around 100 pupils attend each workshop and travel from schools throughout Scotland. The workshops are fully booked each year and run in collaboration with the Glasgow Science Centre and supported by Thermo Fisher. The workshops require the support of around 15-20 volunteers from the CVR and wider MVLS each year. The workshops provide pupils with experience and knowledge they would not normally receive until attending university. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.facebook.com/centreforvirusresearch/ |
Description | CVR Coffee Mornings |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other audiences |
Results and Impact | We have been holding monthly coffee mornings for staff and students within our social space since 2017 to offer an informal opportunity for people working across the centre to meet and network. The events are regularly attended by 50-70 people each time with attendance continuing to grow. Staff and students have provided positive feedback about this opportunity to meet with one another and make use of it as a chance to discuss work related matters or simply to make new connections. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.facebook.com/centreforvirusresearch/ |
Description | CVR Stoker Award 2019 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Every year, CVR early career scientists nominate and vote for an established, outstanding virologist who has made a significant contribution to their field. In 2019 CVR early career researchers presented the award to Professor Ann Palmenberg - plus podcast |
Year(s) Of Engagement Activity | 2019 |
Description | CVR Travel Award |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | One PhD student and one post-doc are each awarded a prize of £1500 to use towards presenting at a conference of their choosing in 2020. The Students and Postdocs are asked to submit an abstract up to 400 words in length (excluding title, authors etc) detailing the work they wish to present at the conference. |
Year(s) Of Engagement Activity | 2020 |
Description | Contagious Thinking podcast S2 ep6: Robert Gifford |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Dr. Robert Gifford, CVR's resident evolutionary virologist and senior research fellow. Rob's lab combines sequence data and software development to explore virus genomics and coevolution of viruses and their hosts. He applies virus genomics to help and guide treatment of HCV-infected patients; support genomic surveillance and outbreak response for bluetongue and rabies; and explore the diversity of endogenous viral elements in published genome sequence data, just to name a few of his projects. Listen to him tell us how he became interested in this paleovirology by starting out working on endogenous retroviruses at Imperial College long before the NGS metagenomics techniques come about. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s2-ep6-robert-j-gifford |
Description | Contagious Thinking podcast S2 ep7: Marlene Dreux |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A podcast with Dr Marlene Dreux, Team Leader in immunovirology at the Centre International de Recherche en Infectiologie (CIRI) in Lyon, France. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s2-ep7-marlene-dreux |
Description | Contagious Thinking podcast S3 ep10: Laura McCoy |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In this episode of Contagious Thinking Connor and Elihu are talking with Dr Laura McCoy about why study and continue to study broadly neutralizing antibodies against HIV, and the role of B cell biology in HIV infection and vaccine responses. She also discusses her career so far, and gives advice to PhD and early career researchers. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep10-laura-mccoy |
Description | Contagious Thinking podcast S3 ep11: Connor Bamford |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In this episode, Jack Hirst and Andrew Burns (on his podcast debut) are joined by Contagious Thinking veteran and founder Connor Bamford, who is crossing to other side and telling us about his own research on a peculiar immune protein that seems to make Hepatitis C infections worse rather than better. |
Year(s) Of Engagement Activity | 2020 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep11-connor-bamford |
Description | Contagious Thinking podcast S3 ep12: Diane Griffiths |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In this episode we're extremely lucky to be welcoming Professor Diane Griffin, from the Johns Hopkins Bloomberg school of public health who is also the vice-president of the US National Academy of Sciences (www.nasonline.org/member-directoryers/3007695.html). Diane - who is an MD/PhD - is a pioneering expert in how viruses cause disease, focusing on those viruses that infect your brain (like measles), and viruses spread by insects (like alphaviruses, such as Sindbis and chikunungya viruses). |
Year(s) Of Engagement Activity | 2020 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep11-diane-griffin |
Description | Contagious Thinking podcast S3 ep1: Juan Fontana |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | This is the third season of the refreshing virology podcast. In this episode, we're starting off with Dr Juan Fontana, a structural biologist from the University of Leeds. Juan speaks with fellow postdoc Connor Bamford, about his career so far in Virology, how cryoEM works, and how he uses this technique to study deadly human viruses. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep1-juan-fontana |
Description | Contagious Thinking podcast S3 ep3: Paul Griffiths |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In this episode we're welcoming Professor Paul Griffiths, from the Royal Free hospital and University College London. Professor Griffiths - who is a clinician by training - came to the CVR in Glasgow earlier this year to give a seminar. Connor Bamford caught up with Paul in this episode and discuss his favourite virus, human cytomegalovirus (CMV), the road to making and testing vaccines against this very important virus, and his surprising side career as an author of factual and fictional science-inspired books. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep3-paul-griffiths |
Description | Contagious Thinking podcast S3 ep4: Pat Nuttall |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Season 3 Episode 3: This week Jack and Douglas are talking ticks with Professor Pat Nuttall, where we hear about how changing conditions are increasing the risk of tick-borne viruses and how these viruses benefit from the peculiar properties of tick saliva. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s2-ep4-pat-nuttall |
Description | Contagious Thinking podcast S3 ep5: Carolina Lopez |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In this special episode for our Spanish speakers listeners, Mila and Elihu are talking with Carolina Lopez about how viruses interact with the immune system during infection. As viruses copy their genomes, a large number of defective copies are made. Carolina studies the different forms of a virus, including those with regular and defective copies of their genome, that are present in an infection and how these different forms interact with the infected cell and influence its function. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep5 |
Description | Contagious Thinking podcast S3 ep6: Paul Lehner |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In this episode of Contagious Thinking Jack and Arthur are talking with Professor Paul Lehner about HIV and silencing of these viruses by the newly discovered HUSH complex. Paul talks about his career so far and his research on HIV. He further explains how he and colleagues discovered the HUSH complex and its role in silencing viruses like HIV. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep6-paul-lehner |
Description | Contagious Thinking podcast S3 ep7: Rachel Ulferts |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In this episode, Dr Connor Bamford speaks with Dr Rachel Ulferts from the Francis Crick Institute in London after she came to Glasgow recently to present her fascinating work. Dr Ulferts is currently a postdoc in the lab of Dr Rupert Beale at the Crick where she works on influenza virus and a cell process known as autophagy - or 'self eating'. Previously Rachel worked on a number of RNA viruses, like coronaviruses or picornaviruses in labs across Europe, including Northern Ireland and The Netherlands, before coming back to the UK to work at The University of Cambridge and then onto London. In this episode Connor talks with Rachel about her work on autophagy, her interest in fundamental virology, and her exciting plans for the future. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/podcast-s3-ep7-rachel-ulferts |
Description | Contagious Thinking podcast: Ann Palmenberg |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Professor Ann Palmenberg from the University of Wisconsin-Madison talking to us about her journey through academia as a virologist, her views on vaccines and women in science. |
Year(s) Of Engagement Activity | 2019 |
URL | https://cvrblog.myportfolio.com/2019-stoker-award-winner-prof-ann-palmenberg |
Description | Contagious Thinking podcast: Siyuan Hu: A Tale of One City |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | In a very special ad hoc episode, we have the personal experience from the inside of the coronavirus outbreak. From mainland China in Wuhan City, fellow postdocs Elihu Araday and Rute Pinto talked with Siyuan Hu, a PhD student in the Professor Margaret Hosie's group, who is currently in Wuhan and living this outbreak from a different perspective. |
Year(s) Of Engagement Activity | 2020 |
URL | https://cvrblog.myportfolio.com/siyuan-hu-a-tale-of-one-city |
Description | Glasgow Science Festival Science Sunday - June 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | CVR researchers took a range of popular activities (build a virus, glovebox chamber game and Biolegomatics along to the Science Sunday event as part of the Glasgow Science Festival. 10 researchers from the CVR volunteered for the event and they estimated that they interacted with around 200 people over the course of the day. The activity was also supported by social media activity. MP Patrick Grady also made a point of visiting the stand to try an activity, take a photograph and tweet about the day. Stand visitors tend to have a keen interest in science but it is an opportunity for families to have a fun day out and learn something new. |
Year(s) Of Engagement Activity | 2019 |
URL | https://twitter.com/CVRinfo/with_replies |
Description | May 2019 - MRC Public Engagement Training Session Steve Cross |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | The MRC offered Public Engagement training from freelance consultant Steve Cross in May 2019. The session was offered to all MRC centres taking part in the MRC Festival of Medical Research across the UK. 12 CVR researchers including a mix of students and staff attended the session and provided positive feedback relating to their experience of the day. |
Year(s) Of Engagement Activity | 2019 |
Description | Meet the Researcher Showcase Event Feb 2020 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Ilaria Epifano and Michaela Conley attended a two day event that took place in both the Dundee and Glasgow Science centres to run an exhibition attended by 200 Higher Biology School pupils from across Scotland each day. Our researchers used our build a virus activity to engage in conversation and took leaflets to share information about entering a career in virology. They estimate that they engaged with around 100 school pupils each day. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.facebook.com/centreforvirusresearch/ |
Description | Outbreak: The Pub Quiz |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Join scientists from the Centre for Virus Research for some infectious fun at this pub quiz! Scientists will share their expertise and challenge your knowledge about the viruses hitting the headlines |
Year(s) Of Engagement Activity | 2019 |
Description | PCR workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Since 2006, this activity has been delivered to more than 700 Scottish high school students. The teaching resources developed have been adopted by Learning Teaching Scotland to teach higher biology. Workshop has been praised in an HMIE report. Evaluation student feedback is very positive each year. Our PCR workshop run in partnership with Glasgow Science Centre is a flagship/exemplar activity in high-school education. The PCR workshop has been cited by HMiE as an example of excellence. School pupils from all over Scotland travel to Glasgow to participate. |
Year(s) Of Engagement Activity | 2013,2014 |