Statistical Genomics and the Analysis of High Dimensional Data

Lead Research Organisation: University of Cambridge

Abstract

To better understand multifactorial diseases such as cancer, autoimmune diseases and cardiovascular diseases, and to ultimately better target treatments to individuals, researchers are using new biotechnologies that measure genetic code at extremely high resolution as well as downstream functional mechanisms essential to the maintenance of human health, and study designs that combine extensive questionnaires, genotyping and biobanks. However, the amount and diversity of information collected render their analysis difficult and statisticians are faced with the challenge of developing efficient dimension reduction approaches that can discover important predictors and patterns among a vast array of possibilities. Our programme proposes to develop a range of improved statistical techniques and algorithms for finding important combinations of features in large genetic and genomics datasets that characterise or predict health outcomes and for carrying out integrative analyses to characterise heterogeneous disease processes. The new methods will be accompanied by the development of freely available software and will be used in a number of collaborative projects to improve understanding of the regulation of genes and immunological response, and to stratify population of patients to better target treatment.

Technical Summary

Motivated by important biomedical collaborations, the broad aim of this programme is to enrich the statistical toolkit that is commonly used in genomics analyses by developing and implementing new analytical strategies for integrative and translational `omics’ as well as for the analysis of single cell data. The core of the proposed models and inference will be embedded within state of the art statistical developments in Bayesian modelling and computations, although analogous penalised approaches will also be investigated and compared to Bayesian implementations.

We will focus on modelling and computational strategies where the multidimensional (e.g. complex multiple-phenotype) and multivariate aspects (many explanatory features) of complex data sets are investigated and exploited at key steps of the analysis strategy. The analysis of complex `omics’ phenotypes will be investigated through the extension of sparse regression approaches to large number of responses, as well as by the use of graphical modelling approaches, which target estimation of the network structure and direct associations between the omics features of interest. Both approaches deal with the large p (large number of features) small n (number of samples) context by using sparse formulations or shrinkage.
One important focus will be to use context specific (e.g. clinical, epidemiological or biological) information to build hierarchical relationships between different sources of data and informative priors based on substantive knowledge. Model uncertainty will be taken into account as part of the Bayesian modelling process.
In complement, a programme of work tackling stratification in precision medicine will be developed. The approach chosen is focussed on formulating semi supervised (outcome guided) integrative clustering models and algorithms to uncover subpopulations of patients that have diagnostic, prognostic or theranostic meaning, using a collection of high dimensional biomarkers

We will use the methods to search for new associations and structures in a range of exemplar case studies demonstrating multiple facets of the applicability of the novel methods that will be developed. In particular, we will investigate gene expression profiling and eQTLs for autoimmune diseases, integrative clustering for subtyping breast cancer in link with survival, and integrative genomics of cardiovascular diseases. Scalability of the algorithms developed will be a focus of attention. The computer programmes implemented will be open source and made publicly available.

Publications

10 25 50
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Ahfock D (2016) Partial identification in the statistical matching problem. in Computational statistics & data analysis

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Ahfock DC (2021) Statistical properties of sketching algorithms. in Biometrika

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Buchholz Alexander (2019) Distributed Computation for Marginal Likelihood based Model Choice in arXiv e-prints

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Cabassi A (2020) Multiple kernel learning for integrative consensus clustering of omic datasets. in Bioinformatics (Oxford, England)

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Chong HP (2019) Age at menarche and the risk of operative delivery. in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

 
Description Contribution to Public Administration and Constitutional Affairs Committee's Eighth Report of Session 2019-21 Government transparency and accountability during Covid 19. The data underpinning decisions
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://committees.parliament.uk/publications/5076/documents/50285/default/
 
Description Data Evaluation and Learning for Viral Epidemics group
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Expert Advisory Group for Foreign Office and Cabinet Office
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Expert Advisory Group for the International Comparators
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description ISBA Committee on Fellows
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description International Best Practice Advisory Group on COVID-19
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Joint Biosecurity Centre for COVID-19
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://www.gov.uk/government/groups/joint-biosecurity-centre
 
Description Lords Science and Technology Committee - UK Science, Research and Technology Capability and Influence in Global Disease Outbreaks
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://committees.parliament.uk/event/1796/formal-meeting-oral-evidence-session/
 
Description Parliamentary Select Committee on Data Transparency and Accountability: COVID-19
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Parliamentary and Scientific Committee - 'COVID-19 - The Statistics and the Science Underlying Them'
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Research Committee of the Health Effects Institute, Boston, US (2005 - 2013)
Geographic Reach North America 
Policy Influence Type Membership of a guidance committee
 
Description Royal Statistical Task Force on COVID-19
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The Royal Statistical Society (RSS) has a task force to marshal and promote, at a high level, the Society's expertise relevant to the COVID-19 crisis. The task force was co-founded by Sylvia Richardson, and she also co-chairs the initiative with RSS past president Sir David Spiegelhalter, and is supported by a steering group.
URL https://rss.org.uk/policy-campaigns/policy/covid-19-task-force/
 
Description • Conseil Scientifique de l'ANSES (Agence Française de Sécurité sanitaire de l'alimentation, l'environnement et du travail) (2010 - 2018)
Geographic Reach Asia 
Policy Influence Type Membership of a guidance committee
 
Description Bringing Innovative Research Methods to Clustering Analysis of Multimorbidity (BIRM-CAM)
Amount £288,826 (GBP)
Funding ID MR/S027602/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2022
 
Description Collaborative European NeuroTrauma Effectiveness Research in TBI
Amount € 228,275 (EUR)
Funding ID 602150 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 09/2013 
End 03/2020
 
Description Data Science THEME
Amount £766,086 (GBP)
Organisation NHS Blood and Transplant (NHSBT) 
Sector Public
Country United Kingdom
Start 01/2019 
End 04/2025
 
Description Determine the genetic causes of rare diseases using detailed phenotype data in the context of whle genome sequencing studies-BHF Non-Clinical CDF
Amount £129,642 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2020 
End 01/2022
 
Description HDR UK Summer Black Intern Programme
Amount £9,600 (GBP)
Funding ID G114299 SLAJ/081 
Organisation Health Data Research UK 
Sector Private
Country United Kingdom
Start 05/2021 
End 08/2021
 
Description Health Data Research UK-studentship
Amount £117,523 (GBP)
Organisation Health Data Research UK 
Sector Private
Country United Kingdom
Start 09/2020 
End 11/2021
 
Description KCL- Spector- A systems based approach to integrating genetic and longitudinal omics data to support diagnosis and prediction of common chronic disease
Amount £143,160 (GBP)
Funding ID MR/M004422/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description MEASURING & UNDERSTANDING MULTIMORBIDITY USING ROUTINE DATA IN THE UK-HDRUK Implementation Project
Amount £59,818 (GBP)
Organisation Health Data Research UK 
Sector Private
Country United Kingdom
Start 09/2019 
End 06/2021
 
Description MRC- MRP- Newcombe- Method development for Mendelian randomisation using summary statistics (MR)
Amount £152,934 (GBP)
Funding ID MR/N027493/1 
Organisation Medical Research Council (MRC) 
Department MRC/NIHR Methodology Research Programme
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Mechanism and diagnosis via integrative clinical immuno-geneomics
Amount £242,422 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2020 
End 08/2024
 
Description New Approaches to Bayesian Data Science: Tackling Challenges from the Health
Amount £519,014 (GBP)
Funding ID EP/R018561/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 07/2024
 
Description New Broad Collaborative
Amount £45,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2021 
End 03/2022
 
Description Population and Quantitative Science BRC theme.
Amount £994,833 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2017 
End 11/2022
 
Description RESISTANCE UNDER COMBINATORIAL TREATMENT IN ER+ AND ER- BREAST CANCER RESCUER
Amount £239,473 (GBP)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2020 
End 12/2024
 
Description Statistician for the GWAS project
Amount £45,856 (GBP)
Organisation Royal Papworth Hospital NHS Foundation Trust 
Sector Public
Country United Kingdom
Start 05/2018 
End 06/2019
 
Description The Alan Turing Institute Turing Fellow Award
Amount £34,999 (GBP)
Organisation Alan Turing Institute 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 09/2019
 
Description Collaboration with Mihaela van der Scharr 
Organisation Alan Turing Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Building a machine learning based collaboration wih the BSU which has resulted in a £10K grant from Alan Turing institute to run a machine learning workshop in March 2019
Collaborator Contribution Provision of data and technical expertise
Impact Grant for machine learning workshop as described above
Start Year 2017
 
Description Collaboration with Mihaela van der Scharr 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Building a machine learning based collaboration wih the BSU which has resulted in a £10K grant from Alan Turing institute to run a machine learning workshop in March 2019
Collaborator Contribution Provision of data and technical expertise
Impact Grant for machine learning workshop as described above
Start Year 2017
 
Description 18th Armitage Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Organised the Unit's 18th Armitage Workshop on the theme of decision-based inference with speakers representing all four BSU research themes. Hybrid workshop which had international reach.
Year(s) Of Engagement Activity 2021
URL https://www.mrc-bsu.cam.ac.uk/news-and-events/armitage-lectureships-and-workshops/18th-armitage-lect...
 
Description AIUK: Is there a post-pandemic AI panacea - Panel discussion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Sylvia Richardson participated in a panel discussion for AIUK event 2021 on the topic of 'Is there a post-pandemic AI panacea'
Year(s) Of Engagement Activity 2021
URL https://www.youtube.com/watch?v=66XDUk5WHRw&list=PLuD_SqLtxSdUXt1kmms31Tlvtp5zjlsbi&index=17&t=2459s
 
Description Armitage Lectures 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Annual workshop and lecture created and hosted by the MRC Biostatistics Unit, to honour the immense contributions of Professor Peter Armitage who was at the unit from 1947 to 1961, and whose work is recognised throughout the world as achieving a successful balance between methodological rigour and applied commonsense, to which all statisticians aspire. An eminent medical statistician visits for a week and works with members of the unit. The highlight is the Armitage Lecture, where more than 100 delegates attend. This event raises the unit research profile and creates new collaborations.
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015,2016,2017
URL https://www.mrc-bsu.cam.ac.uk/news-and-events/armitage-lectureships-and-workshops/
 
Description Armitage Workshop 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Annual BSU Armitage Workshop on theme of statistical genomics. Attracted international keynote speaker from Princeton University and event attracted 110+ delegates from academia and industry.
Year(s) Of Engagement Activity 2018
 
Description Article for Royal Statistical Society - 'How ideas from decision theory can help guide our actions' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sylvia Richardson wrote article for Royal Statistical Society website about what lessons can be learned from decision theory when deciding what the next steps should be for tackling COVID-19.
Year(s) Of Engagement Activity 2021
URL https://rss.org.uk/news-publication/news-publications/2021/general-news/how-ideas-from-decision-theo...
 
Description Article for Significance magazine - 'A perspective on real-time epidemic surveillance for Covid-19' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Sylvia Richardson co-wrote article for Significance magazine entitled 'A perspective on real-time epidemic surveillance for Covid-19'
Year(s) Of Engagement Activity 2020
URL https://www.significancemagazine.com/science/685-a-perspective-on-real-time-epidemic-surveillance-fo...
 
Description Article for The Conversation - 'Vaccine rollouts, school testing and contact tracing could all be improved - here's how' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Sylvia Richardson wrote an article for The Conversation entitled 'Vaccine rollouts, school testing and contact tracing could all be improved - here's how'
Year(s) Of Engagement Activity 2021
URL https://theconversation.com/vaccine-rollouts-school-testing-and-contact-tracing-could-all-be-improve...
 
Description Article for The Observer - 'Coronavirus statistics: what can we trust and what should we ignore?' 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Sylvia Richardson co-wrote article for The Observer newspaper on 'Coronavirus statistics: what can we trust and what should we ignore?'
Year(s) Of Engagement Activity 2020
URL https://www.theguardian.com/world/2020/apr/12/coronavirus-statistics-what-can-we-trust-and-what-shou...
 
Description Article for The Times - 'Pregnant women need to be at front of vaccine queue' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Sylvia Richardson was interviewed for The Times on how the evidence shows that pregnant women need to be vaccinated against COVID-19.
Year(s) Of Engagement Activity 2021
URL https://www.thetimes.co.uk/article/pregnant-women-need-to-be-at-front-of-vaccine-queue-gb579wnvp
 
Description Article for Times Higher Education 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Sylvia Richardson wrote article for Times Higher Education about how the COVID-10 pandemic has sparked huge interest in statistics
Year(s) Of Engagement Activity 2021
URL https://www.timeshighereducation.com/news/rss-head-statisticians-no-longer-party-bores-covid-era
 
Description Article for Times Higher Education - 'RSS head: Statisticians no longer 'party bores' in Covid era' 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Sylvia Richardson was interviewed for article in Times Higher Education on 'RSS head: Statisticians no longer 'party bores' in Covid era'.
Year(s) Of Engagement Activity 2021
URL https://www.timeshighereducation.com/news/rss-head-statisticians-no-longer-party-bores-covid-era
 
Description BSU Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Unit held open day as part of MRC Festival of Medical Research.

The aim of the open day was to welcome secondary school students and members of the general public to come to the unit, find out about the research the unit does, and to take part in activities that illustrate BSU research, with the overall theme being 'Fun with statistics'. An open day of this format was a first for the unit and overall it was a very successful event. There were 40 attendees over a 4 hour event. All attendees pre-booked and were split into 4 groups for a 1 hour session comprising of an introduction, participation in hands-on activities, and a brief careers talk. The small groups and length of session allowed for quality engagement between the scientists and the audience.

Feedback from the attendees was very positive, and the wider MRC Festival activities that took place in Cambridge demonstrated the benefits in delivering these types of events.
Year(s) Of Engagement Activity 2016
URL http://www.mrc-bsu.cam.ac.uk/bsu-open-day-2016-why-are-statistics-important/
 
Description Big Biology Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Participation in Big Biology Day, organised by Hills Road Sixth Form College in Cambridge - a one day annual 'science festival' event open to memebers of the general public to participate in a range of biology based hands-on activities for all ages.

BSU presented a stand with three hands-on, interactive activities, each communicating a simple statistical method or idea, linked to the unit's research themes.
Year(s) Of Engagement Activity 2016
URL http://www.hillsroad.ac.uk/college-life/events/2016/10/15/default-calendar/big-biology-day
 
Description Bright Club (Cambridge) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Paul Kirk, Senior Statistician, took part in Bright Club as part of the Cambridge Science Festival, combining statistical research and comedy in a 10 minute talk, demonstrating that science can be accessible to wide variety of audiences.
Year(s) Of Engagement Activity 2017
 
Description Buchholz- Adaptive Tuning Of Hamiltonian Monte Carlo Within Sequential Monte Carlo, Applibugs Workshop 2019 , Paris, France, 13/06/2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Alexander Buchholz Adaptive Tuning Of Hamiltonian Monte Carlo Within Sequential Monte Carlo, Applibugs Workshop 2019 , Paris, France, 13/06/2019
Year(s) Of Engagement Activity 2019
 
Description Buchholz- • Adaptive Tuning Of Hamiltonian Monte Carlo Within Sequential Monte Carlo, University of Bristol , UK, 01/11/2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Buchholz- • Adaptive Tuning Of Hamiltonian Monte Carlo Within Sequential Monte Carlo, University of Bristol , UK, 01/11/2019
Year(s) Of Engagement Activity 2019
 
Description Buchholz-Contributions to approximate Bayesian Inference, Glasgow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Alexander Buchholz- • Contributions to approximate Bayesian Inference, University of Glasgow, UK, 6/12/2020
Year(s) Of Engagement Activity 2020
 
Description Buchholz-Contributions to approximate Bayesian Inference, Warwick 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Alexander Buchholz- • Contributions to approximate Bayesian Inference, University of Warwick, UK, 17/1/2020
Year(s) Of Engagement Activity 2020
 
Description CSAP Podcast: Science, Policy and Pandemics 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Sylvia Richardson takes part in podcast organised by the Centre for Science and Policy, discussing lessons learnt during the COVID-19 pandemic and how researchers might use those lessons to prepare for future pandemics.
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=LB1aQb6Q3vc&feature=youtu.be
 
Description Cambridge BSU Lectures in Biomedical Data Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Sylvia Richardson is the co-founder and co-chair of flagship lecture series hosted by the Unit on the topic of biomedical data science. Inviting expert speakers from across the world to give lectures. Three lectures organised so far with a collective audience reach of nearly 1000, including YouTube views.
Year(s) Of Engagement Activity 2021,2022
URL https://www.mrc-bsu.cam.ac.uk/news-and-events/cambridge-bsu-lectures-in-biomedical-data-science/
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Each year BSU participate in Cambridge Science Festival - members of the general public explore and discuss issues of scientific interest and concern, through a series of different events. The event also aims to raise aspirations by encouraging young people to consider a career in science, technology, engineering or mathematics.

BSU take part over two full days - 'Science Saturday' and the 'Cambridge Biomedical Campus' day. The unit presents a stand with 4 - 5 interactive activities that each communicate a basic statistical method or idea, representing one of the four research themes in the unit. Each year a new activity is developed and delivered requiring scientific input from staff across the unit. Over the two days, BSU engage with approximately 500 adults and children who visit the festival.


Raising the profile of the Unit in the region
Increase in request for further information
Audience asked for more opportunities for communication and interaction with the public health researchers
This event contributed to raise the profile of Biostatistics in medical research
This event contributed to enhance the methodological quality of medical research developed by BSU staff
This event contributed to enable Best Research for Best Health
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016,2017
URL http://www.cam.ac.uk/science-festival
 
Description Cambridge Science Festival 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stand at Cambridge Science Festival 2019, presenting two interactive hands-on activities developed by researchers across the BSU; one explaining probability and risk, and the other on precision medicine. Reaching out to 500+ audience members over 1 day.
Year(s) Of Engagement Activity 2019
 
Description Computational Medicine Research Skills Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Workshop for Cambridge University medical students, organised under the auspices of the Cambridge University Student Clinical Research Society. Paul Kirk, Senior Statistician, organised and delivered the workshop (jointly with Dr Caroline Morton, education fellow at Imperial College London).
Year(s) Of Engagement Activity 2018
URL https://www.facebook.com/events/146342029489401/
 
Description Interview for Sky News 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Sylvia Richardson carried out a live interview for Sky News about the Brazilian variant of COVID-19 being spread in the UK.
Year(s) Of Engagement Activity 2021
 
Description Interview for WELT TV 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Kevin Kunzmann was interviewed for German TV news channel, WELT TV, on research he is lead author on about the benefits of lateral flow testing to help keep schools open.
Year(s) Of Engagement Activity 2021
 
Description Machine learning meets statistics conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Scientific co-organiser for new, innovative conference on topic of machine learning meets statistics: guiding medicine into the future. Conference attracting 140 delegates from around the UK and keynote speakers from USA, across varying research backgrounds, including industry. Conference organised in collaboration with The Alan Turing Institute and part funded by the ATI.
Year(s) Of Engagement Activity 2019
 
Description Media enquiry - Cambridge TV 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Paul Kirk, Senior Investigator Statistician, gave interview for Cambridge TV about the BSU open day, discussing what the open day is about, the activities involved, and who it is for. Promoting the MRC Festival of Medical Research.
Year(s) Of Engagement Activity 2016
 
Description Panel discussant and organising committee (`Recent and future trends in biostatistics` workshop) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Early career statisticians from the UK and EU attended a workshop on "Recent and future trends in biostatistics", hosted at the MRC Biostatistics Unit in Cambridge. Paul Kirk, Senior Statistician, took part in a panel discussion and helped to organise the event.
Year(s) Of Engagement Activity 2017
URL https://www.mrc-bsu.cam.ac.uk/blog/workshop-inspires-early-career-biostatisticians/
 
Description RSS Presidency Speech 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Sylvia Richardson gave talk for the launch of becoming the new President of the Royal Statistical Society
Year(s) Of Engagement Activity 2021
 
Description Ruffieux- International Biometric Society (IBS) ROeS Conference Lausanne, Switzerland - A global-local approach for detecting hotspots in multiple-response regression 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International Biometric Society (IBS) ROeS Conference Lausanne, Switzerland -
Talk by Helene Ruffieux on "A global-local approach for detecting hotspots in multiple-response regression"
Year(s) Of Engagement Activity 2019
 
Description Ruffieux- Statistical Methods for Post Genomic Data (SMPGD) Conference Paris, France A global-local variational approach for detecting hotspots in molecular quantitative trait locus studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Statistical Methods for Post Genomic Data (SMPGD) Conference Paris, France
Talk by Helene Ruffieux on "A global-local variational approach for detecting hotspots in molecular quantitative trait locus studies"
Year(s) Of Engagement Activity 2019
 
Description Science Showoff 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Paul Kirk, Senior Investigator Statistician, took part in Cambridge and London Science Showoff events, combining statistical research and comedy in a 10 minute talk, demonstrating that science can be accessible to wide variety of audiences.

Paul has since been asked to take part in similar future events.
Year(s) Of Engagement Activity 2016
 
Description Seaman- Adjusting for time-dependent confounding in survival analysis using structural nested cumulative survival time models 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Shaun Seaman
02/10/19
De Morgan House, London Mathematical Society, London
International Biometric Society half-day event on New perspectives on studying the effects of treatment on a time to event outcome
Title of my talk: Adjusting for time-dependent confounding in survival analysis using structural nested cumulative survival time models
Year(s) Of Engagement Activity 2019
 
Description Seaman- Handling time-dependent confounding using a structural nested cumulative survival time model 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Shaun Seaman
17/07/19
ISCB 2019, Leuven, Belgium
Title of my talk: Handling time-dependent confounding using a structural nested cumulative survival time model
Year(s) Of Engagement Activity 2019
 
Description Seaman- Handling time-dependent confounding using a structural nested cumulative survival time model- London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Shaun Seaman
15/12/19
CM Statistics conference, Senate House, University of London, London
Title of my talk: Handling time-dependent confounding using a structural nested cumulative survival time model
Year(s) Of Engagement Activity 2019
 
Description Seaman-Double Robust Methods for Missing Data 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Shaun Seaman
13/03/19
ESSEC Business School, La Defence, Paris
Title of my talk: Double Robust Methods for Missing Data
Year(s) Of Engagement Activity 2019
 
Description Talk for Statistics Meets Public Health seminar series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk on "Mapping Health" for new seminar series established by Sylvia Richardson - aiming to illustrate how statistics helps to find answers to a range of public health related questions.
Year(s) Of Engagement Activity 2016
 
Description Talk for The Turing Presents: AI UK 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Sylvia Richardson giving talk at The Turing Presents: AI UK 2021 conference
Year(s) Of Engagement Activity 2021
 
Description University of Birmingham Centre for Computational Biology Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Staff and students of the University of Birmingham attended a seminar and subsequent discussion of work by Paul Kirk, Senior Statistician, leading to ideas for future work and potential collaborations.
Year(s) Of Engagement Activity 2018
URL https://www.birmingham.ac.uk/research/activity/mds/centres/computational-biology/news/2017/CCB-Semin...
 
Description University of Warwick Statistics Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Staff and students of the University of Warwick attended a seminar and subsequent discussion of work by Paul Kirk, Senior Statistician, leading to ideas for future work and potential collaborations.
Year(s) Of Engagement Activity 2017
URL https://warwick.ac.uk/fac/sci/news/filtered/?calendarItem=8a17841a5c872aca015cd045dbfa7ad0
 
Description What statisticians do? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact What statisticians do? Talk to Swiss sixth from students
Year(s) Of Engagement Activity 2019
 
Description Workshop talk at Berkley 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Sylvia Richardson gave talk on "Statistical approaches for Precision Medicine"
Year(s) Of Engagement Activity 2016
 
Description Workshop talk at Brunel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Sylvia Richardson gave talk on " Analysis of complex phenotypes in genomics"
Year(s) Of Engagement Activity 2016
 
Description Workshop talk at Lancaster University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Sylvia Richardson gave talk to students at Lancaster University on "Using random matrix projections to facilitate analyses of very large data sets in genomics"
Year(s) Of Engagement Activity 2016
 
Description Written in Blood: What can blood cells tell us about health and disease? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Written in Blood: What can blood cells tell us about health and disease? Talk a Cambridge Science Festival
Year(s) Of Engagement Activity 2019
URL http://www.donorhealth-btru.nihr.ac.uk/btru_events/2018-19-seminar-series/