Mental Ageing

Lead Research Organisation: University College London

Abstract

Mental ageing refers to change or stability in later life cognition (i.e. knowing, learning and reasoning) and emotion (i.e. anxiety, depression and positive wellbeing). These processes are fundamental to our health, everyday life, and survival; which is why impairments in these functions are the biggest cause of disability in the UK.
Our aim is to investigate influences in these functions across the life course, and the consequences of this for daily living and other aspects of health. To achieve this we will study three themes. First, we will investigate cognitive and emotional resilience, i.e. good (or good enough) function in spite of adversity. Second, we will investigate cognitive and emotional function in relation to cardiovascular (i.e. heart and blood vessel) function; this is important because most of the modifiable risks we know about for dementia are cardiovascular in nature, particularly in midlife. Third, we will investigate the life course epidemiology of emotional function. Of particular interest here is whether depression becomes more or less common in later life, and if so, what factors across the life course determine that change in risk.

Technical Summary

Aim
We will investigate the life course causes and consequences of mental ageing, with regard to cognitive and psychological states and their change.
Background
Mental ageing is fundamental to almost all major life outcomes, including other aspects of health, social relationships, economic security, independent living, and survival. Thus, impairments in cognitive and psychiatric state are, in combination, the biggest cause of disability in the UK.
Methods
This programme will be centred on the MRC National Survey of Health and Development (NSHD, the British 1946 birth cohort), requiring complex longitudinal and trans-system modelling; and on DELPHIC (acute stress).
Objectives
To investigate cognitive and mental resilience to acute and chronic stressors
To investigate mental ageing in regard to cerebrovascular health
To investigate the life course epidemiology of depression

Publications

10 25 50
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Elhakeem A (2019) Day-to-day physical activity producing low gravitational impacts is associated with faster visual processing speed at age 69: cross-sectional study. in European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity

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John A (2019) Longitudinal associations of affective symptoms with mid-life cognitive function: evidence from a British birth cohort. in The British journal of psychiatry : the journal of mental science

 
Description House of Lords Select Committee on Healthy Ageing
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://www.parliament.uk/business/committees/committees-a-z/lords-select/science-and-technology-com...
 
Description Inspire Award
Amount £15,000 (GBP)
Organisation Alzheimer's Society 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 05/2020
 
Description Chinese University of Hong Kong 
Organisation Chinese University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Provide cognition and mental health expertise. Advising on analysis and manuscript preparation.
Collaborator Contribution Data analysis and manuscript preparation.
Impact PMID: 27807316 Lee AT, Chan WC, Chiu HF, Richards M, Hui LY, Ng SP, Chan WM, Lam LC. Physical health and lifestyle predictors for significant cognitive impairment in community-dwelling Chinese older adults in Hong Kong. Hong Kong Med Journal, 2016, 22 Suppl 6, 37-39. Lee A, Richards M, Chan Wai C, Chiu H, Lee R, Lam L. Lower risk of incident dementia among older adults having 3 servings of vegetables and 2 servings of fruits a day. PMID:28338708 Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW. Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults. JAMA Psychiatry. 2018;75(7):697-703. doi:10.1001/jamapsychiatry.2018.0657 Lee A, Richards M, Chan WC, Chiu H, Lee R, Lam L. Higher dementia incidence in older adults with type 2 diabetes and large reduction in HbA1c. Age and Ageing 2019, 48, 838-844.PMID: 31574142
Start Year 2016
 
Description Collaborating with HALCyon cohorts 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University College London
Department Institute of Education (IOE)
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University of Portsmouth
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaborating with HALCyon cohorts 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing research expertise
Collaborator Contribution data sharing and research expertise
Impact Numerous research papers including 23818103
Start Year 2008
 
Description Collaboration with Japanese University 
Organisation Tokyo Metropolitan Institute of Medical Science
Department Department of Psychiatry & Behavioral Science
Country Japan 
Sector Academic/University 
PI Contribution NSHD data sharing Housing two researchers at LHA for a period of 12 months. One in 2013-14 and one in 2014-15. Provide advice on the project to do with mental health and aspects of personality To build the collaborative relationship between MRC Unit for Lifelong Health and Aging and the Tokyo Teen Cohort Project.
Collaborator Contribution 1. To seek the key factors which affecting the development of self-regulation in adolescence by using the data from the 1946 British Birth Cohort Study. 2. To investigate a range of health outcomes in relation to discrepancies between verbal and non-verbal cognitive function in NSHD specifically work on social outcomes in those with dyslexia in the NSHD. 3. To learn the management methodology of long-term birth cohort study by committing your current research (MRI study) of the 1946 British Birth Cohort Study. 3. To build the collaborative relationship between MRC Unit for Lifelong Health and Aging and our Tokyo Teen Cohort Project.
Impact A research fellow will be visiting LHA for 12 months to work on NSHD data. Another researcher will be visiting the Unit for 12 months in March 2014. PMID 24714378 Nishida et al PMID 25315221 Nishida et al PMID 26752724 Nishida et al PMID 26449420 Koike et al Adolescent self control behavior predicts body weight through the life course: a prospective birth cohort study. PMID 27279898 Nishida Endo K 2017, Preference for Solitude, Social Isolation, Suicidal Ideation, and Self-Harm in Adolescents.PMID: 28457686 Koike S 2017, Cognitive profiles in childhood and adolescence differ between adult psychotic and affective symptoms: a prospective birth cohort study. Psychol Med. 2017 Oct 9:1-12. PMID:28988550 PMC5729848. Koike S 2018, Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: a prospective birth cohort study. PMID: 29331705 Koike S, Richards M, Wong A, Hardy R. Fat Mass and Obesity Associated (FTO) rs9939609 Polymorphism Modifies the Relationship between body mass index and Affective Symptoms through the Life Course: a prospective birth cohort study. Translational Psychiatry 2018 Mar 13;8(1):62. doi: 10.1038/s41398-018-0110-1. Morimoto Y, Yamasaki S, Ando S, Koike S, Fujikawa S, Kanata S, Endo K, Nakanishi M, Hatch S, Richards M, Kasai K, Hiraiwa-Hasegawa M, Nishida A. Purpose in life and tobacco use among community-dwelling mothers of early adolescents. BMJ Open 2018 Apr 20;8(4):e020586. doi: 10.1136/bmjopen-2017-020586. Nakanishi M, Yamasaki S, Endo K, Ando S, Morimoto Y, Fujikawa S, Kanata S, Takahashi Y, Furukawa TA, Richards M, Hiraiwa-Hasegawa M, Kasai K, Nishida A. The association between role model presence and self-regulation in early adolescence: A cross-sectional study. PMID: 31536579 Nakanishi M, Yamasaki S, Nishida A, Richards M. Midlife Psychological Well-being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort. J Alzheimers Dis. 2019 Oct 17. doi: 10.3233/JAD-190590. [Epub ahead of print] PMID: 31640097
Start Year 2012
 
Description Collaboration with Uni of West Sussex/Leiden 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers.
Collaborator Contribution We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers.
Impact Xu PMID: 26125156 Gaysina PMID: 26439078 PhD supervision ET Secinti E 2017. Research Review: Childhood chronic physical illness and adult emotional health - a systematic review and meta-analysis. PMID: 28449285. Xu MK 2017. Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. PMID:29075213
Start Year 2014
 
Description Collaboration with Uni of West Sussex/Leiden 
Organisation University of Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers.
Collaborator Contribution We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers.
Impact Xu PMID: 26125156 Gaysina PMID: 26439078 PhD supervision ET Secinti E 2017. Research Review: Childhood chronic physical illness and adult emotional health - a systematic review and meta-analysis. PMID: 28449285. Xu MK 2017. Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. PMID:29075213
Start Year 2014
 
Description Collaborations on cognitive ageing NES 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Ongoing collabroation on LHA/NSHD Cognitive ageing programme. Scientific leads on study design and drafting manuscripts vary, involves data sharing, analysis, interpretation and revision of manuscripts.
Collaborator Contribution Experitise in cognitive ageing
Impact Richards et al 2009 (with Batty) Richards et al Lifetime Antecedents of cognitive reserve. In Stern Y (ed). Cognitive Reserve. New York: Psychology Press Hatch et al 2007 17397976 18079429 18718979 Richards, M., Sacker, A., Deary, I.J. (2006) Lifetime antecedents of cognitive reserve. In Stern. Y. (ed.) Cognitive Reserve. Psychology Press, New York. Richards, M. (2006) Do heavier babies make brighter children? In Murray, R., McCabe, J., McGuffin, P., O'Daly, O. and Wright, P. (eds). Beyond nature and nurture: genes, environment and their interplay in psychiatry. Martin Dunitz. Denier N, Clouston SAP, Richards M, Hofer SM. Retirement and cognition: A life course view. Advances in Life Course Research 2017, 31, 11-21. Clouston S, Kotov R, Pietrzak R, Luft B. Gonzalez A, Richards M, Ruggero C, Spiro A, Bromet E. Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. Alzheimer's & Dementia: Diagnosis, Assessment and Disease Monitoring, 2016, 4, 67-75. Kate Xu paper parental bonding instrument PMID 27485970 Received back data set from Kate Xu Secinti E, Thompson EJ, Richards M, Gaysina D. Childhood chronic physical illness and adult emotional health: a systematic review and meta-analysis. In press: Journal of Child Psychology and Psychiatry. 2017 Jul;58(7):753-769. PMID: 28449285. PMID 24598045 Horvat et al PMID 24357571Richards et al PMID 24482683 Silverwood et al PMID 25001968 Gaysina et al PMID 23178897 Gaysina et al Clouston PMID: 27940567 A life course approach to health literacy: The role of gender, educational attainment, and lifetime cognitive capability Denier o Denier N, Clouston SAP, Richards M, Hofer SM. Retirement and cognition: A life course view. Advances in Life Course Research 2017, 31, 11-21. Clouston PMID: 27626057 Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. .Xu MK, Gaysina D, Tsonaka R, Morin AJS, Croudace TJ, Barnett JH, Houwing-Duistermaat J, Richards M, Jones PB; LHA Genetics Group. Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. Front Psychol. 2017 Oct 11;8:1736. PMID:29075213 Clouston SAP, Smith DM, Mukherjee S, Zhang Y, Hou W, Link BG, Richards M. Education and cognitive decline: An integrative analysis of global longitudinal studies of cognitive aging. J Gerontol B Psychol Sci Soc Sci. 2019 May 6. pii: gbz053. doi: 10.1093/geronb/gbz053. [Epub ahead of print] PMID: 31059564 Clouston S, Diminich E, Kotov R, Pietrzak R, Richards M, Spiro A, Deri Y, Carr M, Yang X, Gandy S, Sano M, Bromet E, Luft B. Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events of 9/11/2001. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2019, 11, 628-636
Start Year 2006
 
Description Collaborations on mental health NES 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers.
Collaborator Contribution Development of LHA/NSHD mental health research programme
Impact Publications (not otherwise specified under other collaborations involving these collaborators): Richards M, Goldberg D. Are there early adverse exposures that differentiate depression and anxiety risk? In: Goldberg D, Kendler KS, Sirovatka P, Regier DA (eds). Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V. Arlington, VA: American Psychiatric Association 19131382 19379961 18827297 18295901 17976252 17692292 17202554 17487877 16777388 16880486 16734949 16393365 18378866 PMID 25066933 Colman et al PMID 24357583 Byford PMID 26835144 Tikhonoff New award, with Richards as co-investigator: Harmonisation of mental health measures in British birth cohorts. (PI: G Ploubidis, UCL). ESRC. June 2018-July 2019. Total value: £72,918.80 New Award Co-investigator: Assessment and harmonisation of cognitive measures in British birth cohorts (PI: Vanessa Moulton, UCL). ESRC. July 2018-June 2019. Total value: £67,265.00.
Start Year 2006
 
Description Collaborations on mental health NES 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers.
Collaborator Contribution Development of LHA/NSHD mental health research programme
Impact Publications (not otherwise specified under other collaborations involving these collaborators): Richards M, Goldberg D. Are there early adverse exposures that differentiate depression and anxiety risk? In: Goldberg D, Kendler KS, Sirovatka P, Regier DA (eds). Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V. Arlington, VA: American Psychiatric Association 19131382 19379961 18827297 18295901 17976252 17692292 17202554 17487877 16777388 16880486 16734949 16393365 18378866 PMID 25066933 Colman et al PMID 24357583 Byford PMID 26835144 Tikhonoff New award, with Richards as co-investigator: Harmonisation of mental health measures in British birth cohorts. (PI: G Ploubidis, UCL). ESRC. June 2018-July 2019. Total value: £72,918.80 New Award Co-investigator: Assessment and harmonisation of cognitive measures in British birth cohorts (PI: Vanessa Moulton, UCL). ESRC. July 2018-June 2019. Total value: £67,265.00.
Start Year 2006
 
Description Computational Platform for Assessment of Cognition In Dementia (C-PLACID) - UCL 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide cognitive ageing expertise
Collaborator Contribution The overall objectives of this project are to: - Enhance the cognitive assessment of people with dementia through computational, mathematical and engineering innovation. - Develop a computational platform that will support substantial improvements in the analysis and visualisation of complex cognitive datasets, and the automatization, optimization and innovation of techniques and devices used to acquire cognitive data. The specific objectives are to: - Generate multivariate cognitive profiles in different dementias. - Create algorithms to predict the evolution of cognitive events, particularly in rare and atypical dementias. - Improve existing tests through the automatic measurement of voice reaction times and implementation of psychophysical principles. - Enhance existing cognitive assessment paradigms by utilizing eyetracking. - Develop novel 'instruction-less' tests of cognition suitable for patients with different types and severities of dementia. - Build novel sensors of participant reactions to complex social and other scenarios. - Use virtual reality to evaluate social cognition in fronto-temporal dementia.
Impact EPSRC Sensing and Imaging for the Diagnosis of Dementia grant awarded to Institute of Neurology. The eye-tracking component of this is now embedded within wave 2 of Insight 46
Start Year 2014
 
Description Haggarty Epigenetics Aberdeen 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on imprinting methylation; early life influences and later cognition and mood
Collaborator Contribution Collaboration on imprinting methylation; early life influences and later cognition and mood
Impact First Joint meeting 10th March 2016 Lorgen-Ritchie M, Murray AD, Ferguson-Smith AC, Richards M, Horgan GW, Phillips LH, Hoad G, Gall I, Harrison K, McNeill G, Ito M, Haggarty P. Imprinting methylation in SNRPN and MEST1 in blood predicts cognitive ability. PLoS One 2019 Feb 1;14(2):e0211799. doi: 10.1371/journal.pone.0211799. eCollection 2019. Erratum in: PLoS One 2019 Apr 10;14(4):e0215422.
Start Year 2015
 
Description Insight 46 Study 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution A subset of study members from NSHD will undergo positron emission tomography (PET) to detect early deposition of fibrillar beta-amyloid (Aß) and other misfolded proteins involved in the pathogenesis of Alzheimer's disease; (2) sensitive MRI techniques to measure early cortical and sub-cortical atrophy, cerebrovascular lesions, cerebral blood flow, and regional metabolic rate of oxygen. NSHD will coordinate the study and review the potential to add in additional assessments (auditory and visual) around this sub-study
Collaborator Contribution The PET scans and MRI techniques will be carried out by collaborators at Queens Square. They will also interpret the scans. Our collaborators are also helping the initial organisation/logistics of the study.
Impact Funding from the Wolfson Foundation for a neuroimaging sub-study for 500 NSHD study members Grant application submitted but not successful to Welcome Trust Funding from ARUK for 3 day study manager and 1 day of senior study manager (128,000) Training, equipment and documents purchased/created Abstracts submitted to Alzheimer's Association International Conference, May 2017. 500 participants seen and wave 1 has been completed. Wave 2 is underway. Lane CA, Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development.BMC Neurol. 2017 Apr 18;17(1):75. doi: 10.1186/s12883-017-0846-x. PMID:28420323 James SN, Lane CA, Parker TD, Lu K, Collins JD, Murray-Smith H, Byford M, Wong A, Keshavan A, Buchanan S, Keuss SE, Kuh D, Fox NC, Schott JM, Richards M. Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46. BMC Res Notes. 2018 Dec 13;11(1):885. doi: 10.1186/s13104-018-3995-0. PMID: 30545411 Lane C, Parker T, Macpherson K, Murray-Smith H, Cash D, Thomas D, Byford M, Wong A, Modat M, Malone I, Klimova J, Burgos N, Hutel M, Melbourne A, Donnachie E, Esser P, Dawes H, Husain M, Hoskote C, Shah S, + others, Frost C, Hardy R, Bras J, Hardy J, Zhang H, Zetterberg H, Ourselin S, Sharma N, Crutch SJ, Kuh D, Richards M*, Fox NC*, Schott JM* (joint senior). Study Protocol: Insight 46, a neuro-imaging sub-study of the MRC National Survey for Health and Development 1946 Birth cohort. BMC Neurology 2017 Apr 18;17(1):75. doi: 10.1186/s12883-017-0846-x. James SN, Wong A, Tillin T, Hardy R, Chaturvedi N, Richards M. Mid-life insulin resistance and type 2 diabetes on older age cognition: The explanatory role of early life advantage. PMID: 31359084 Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Parker TD, Malone IB, Lu K, James SN, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Gordon E, Coath W, Barnes A, Dickson J, Modat M, Thomas D, Crutch SJ, Hardy R, Richards M, Fox NC, Schott JM.Investigating the associations between blood pressure across adulthood and late-life brain structure and pathology in the 1946 British birth cohort: an epidemiological study. Lancet Neurol. 2019 Oct;18(10):942-952. PMID:31444142 PMCID:PMC6744368 Keuss SE, Parker TD, Lane CA, Hoskote C, Shah S, Cash DM, Keshavan A, Buchanan SM, Murray-Smith H, Wong A, James SN, Lu K, Collins J, Beasley DG, Malone IB, Thomas DL, Barnes A, Richards M, Fox N, Schott JM.Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort.BMJ Open. 2019 Jul 31;9(7):e029502. doi: 10.1136/bmjopen-2019-029502. Lu K, Nicholas JM, Collins J, James SN, Parker TD, Lane C, Keshavan A, Keuss SE, Buchanan S, Murray-Smith H, Cash DM, Sudre CH, Malone IB, Coath W, Wong A, Henley S, Crutch SJ, Fox NC, Richards M, Schott JM. Cognition at age 70: life course predictors and associations with brain pathologies. PMID: 31666352 Parker TD, Cash DM, Lane CAS, Lu K, Malone IB, Nicholas JM, James SN, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Sudre CH, Modat M, Thomas DL, Crutch SJ, Richards M, Fox NC, Schott JM.Hippocampal subfield volumes and pre-clinical Alzheimer's disease in 408 cognitively normal adults born in 1946PLoS One. 2019 Oct 17;14(10):e0224030. doi: 10.1371/journal.pone.0224030. eCollection 2019 PMID: 31622410 PMCID: PMC6797197 Parker T, Cash DM, Lane C, Lu K, Malone IB, Nicholas JM, James S, Keshavan A, Murray-Smith H, Wong A, Buchannan S, Keuss S, Sudre CH, Thomas D, Crutch S, Bamiou DE, Warren JD, Fox NC, Richards M, Schott JM.Pure tone audiometry and cerebral pathology in healthy older adults.J Neurol Neurosurg Psychiatry. 2020 Feb;91(2):172-176. doi: 10.1136/jnnp-2019-321897. Epub 2019 Nov 7.PMID: 31699832 Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Malone IB, Parker TD, Keshavan A, Buchanan SM, Keuss SE, James SN, Lu K, Murray-Smith H, Wong A, Gordon E, Coath W, Modat M, Thomas D, Richards M, Fox NC, Schott JM.Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.JAMA Neurol. 2019 Nov 4:1-9. doi: 10.1001/jamaneurol.2019.3774. [Epub ahead of print]PMID: 31682678 James AN, Lane CA, Parker TD, Lu K, Collins JD, Murray Smith H, Byford M, Wong A, Keshavan A, Buchanan S, Keuss SE, Kuh D, Fox NC, Schott JM, Richards Using a birth cohort to study brain health and preclinical dementia: Recruitment and participation rates in Insight 46. BMC Research Notes 2018;11:885
Start Year 2012
 
Description KX collaboration 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution Provides cognitive expertise and NSHD data, advice on study design, data analysis and manuscript preparation
Collaborator Contribution Data analysis and creation of manuscripts
Impact Xu Parental bonding instrument PMID 27485970 Data set received
Start Year 2016
 
Description Mental health and other psychological therapy Outcomes; their relationship to Dementia Incidence in the Following Years (MODIFY) 
Organisation University College London
Department Division of Psychology & Language Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Research about the topic of Mental health and other psychological therapy Outcomes - provide data and mental health expertise for analysis and manuscript preparation
Collaborator Contribution Research about the topic of Mental health and other psychological therapy Outcomes - provide data and expertise for analysis and manuscript preparation
Impact Successful grant application to Alzheimer's Society
Start Year 2020
 
Description OOTLES (Out Of The Long Economic Shadows) 
Organisation London School of Economics and Political Science (University of London)
Country United Kingdom 
Sector Academic/University 
PI Contribution ESRC STAI-funded collaboration to estimate £ costs of adolescent mental health problems. Mental health research expertise, analysis, advice on manuscripts
Collaborator Contribution ESRC STAI-funded collaboration to estimate £ costs of adolescent mental health problems. Health economics expertise, analysis, advice on manuscripts
Impact First draft paper currently in progress
Start Year 2019
 
Description SABRE 
Organisation University College London
Department Institute of Cardiovascular Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide cognition and mental health expertise. Advising on analysis and manuscript preparation.
Collaborator Contribution Data analysis and manuscript preparation
Impact Park C, Williams E, Chaturvedi N, Tillin T, Stewart R, Richards M, Shibata D, Mayet J, Hughes A. Associations between left ventricular dysfunction and brain structure and function: Findings from the SABRE study. PMID:28420646 PMC5533007
Start Year 2016
 
Description Stonybrook University Collaboration (SC) 
Organisation Stony Brook University
Country United States 
Sector Academic/University 
PI Contribution Collaboration on cognitive ageing in the NSHD Advising and collaborating on papers
Collaborator Contribution Collaboration on cognitive ageing in the NSHD Analysing data, collaborating on papers
Impact PMID: 26315501 Denier N 2017. Retirement and cognition: A life course view. PMID: 28781588. Clouston S 2017.Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. PMID: 27626057 Clouston S 2017. Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders. PMID: 29201993 Clouston SAP, Smith DM, Mukherjee S, Zhang Y, Hou W, Link BG, Richards M. Education and cognitive decline: An integrative analysis of global longitudinal studies of cognitive aging. J Gerontol B Psychol Sci Soc Sci. 2019 May 6. pii: gbz053. doi: 10.1093/geronb/gbz053. [Epub ahead of print] PMID: 31059564 Clouston S, Diminich E, Kotov R, Pietrzak R, Richards M, Spiro A, Deri Y, Carr M, Yang X, Gandy S, Sano M, Bromet E, Luft B. Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events of 9/11/2001. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2019, 11, 628-636
Start Year 2014
 
Description UK Dementia Platform 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Public 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation Swansea University
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description UK Dementia Platform 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants.
Collaborator Contribution The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform.
Impact Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1
Start Year 2009
 
Description Alzheimer's research UK stall at New Scientist live 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We had a stand at this event to promote the cognitive research the unit carries out funded by ARUK by providing information to the general public and letting them play educational games to learn more about it. People took leaflets and engaged with the scientists by asking questions.
Year(s) Of Engagement Activity 2019
 
Description Buchanan, ABN Edinburgh (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Sarah Buchanan submitted an abstract and was invited to present an oral presentation entitled, "Relationships between walking speed, cognition & brain pathologies - an imaging study of the 1946 birth cohort".
Year(s) Of Engagement Activity 2019
 
Description Buchanan, International Congress of Parkinson's Disease and Movement Disorders France (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Sarah Buchanan presented a poster at the 2019 International Congress of Parkinson's Disease and Movement Disorders in Nice, France. The poster was entitled, "The cognitive profile associated with mild parkinsonian signs in a British Birth Cohort at age 69-71."
Year(s) Of Engagement Activity 2019
 
Description Its all academic 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact LHA hosted a Science Fair at UCL with the MRC Laboratory for Medical Cell Biology and the MRC Prion. This was a free family fun day for all ages and included hands-on activities, interactive demonstrations, games and exhibitions. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing.
Year(s) Of Engagement Activity 2019
 
Description James, AAIC Los Angeles (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Sarah James was invited to give an oral presentation at AAIC 2019 in Los Angeles entitled, "Divergent associations between life course cognitive trajectories and brain pathologies: findings from the 1946 British birth cohort."
Year(s) Of Engagement Activity 2019
 
Description Keir Starmer Visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact Sir Keir Starmer, the Unit's local MP, met with staff, who explained the history of the NSHD and the
most important findings. He learnt about Insight 46, Delphic and SABRE. He was particularly
interested in understanding how people can age better, the extent of health inequalities across the
country and what we can do to help shape future government policies.
Year(s) Of Engagement Activity 2019
 
Description Keshavan, AAIC Los Angeles (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Ashvini Keshavan was invited to give a presentation at AAIC 2019 in Los Angeles entitled, "Plasma tau and serum neurofilament light chain in Insight 46 - associations with cognition and brain imaging."
Year(s) Of Engagement Activity 2019
 
Description Keshavan, ARUK Student Day (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Ashvini Keshavan gave a presentation at the 2019 ARUK Student Day that was entitled, "Blood biomarkers of amyloid, tau and neurofilament light chain in the 1946 British birth cohort - relationships with cerebral amyloid and brain imaging."
Year(s) Of Engagement Activity 2019
 
Description Lane, AAIC Los Angeles (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Chris Lane was invited to give an oral presentation at AAIC 2019 in Los Angeles. The presentation was entitled, "Early Adulthood Vascular Risk Strongly Predicts Brain Volumes and White Matter Disease, but Not Amyloid Status, at Age 69-71 Years - Evidence from a British Birth Cohort."
Year(s) Of Engagement Activity 2019
 
Description MRC Festival June 2019 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact LHA hosted a Science Fair at UCL with the MRC Laboratory for Medical Cell Biology and the MRC Prion.This was a free family fun day for all ages andincluded hands-on activities, interactive demonstrations, games and exhibitions. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing.
Year(s) Of Engagement Activity 2019
 
Description Parker, AAIC Los Angeles (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Thomas Parker was invited to give an oral presentation at AAIC 2019 in Los Angeles. The presentation was entitled, "Age, ß-amyloid and cognition selectively influence individual hippocampal subfield volumes: a study of 408 healthy adults born in 1946."
Year(s) Of Engagement Activity 2019
 
Description Press coverage following a paper published in The Lancet re blood pressure and cognition 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact There was extensive press coverage following a paper published in The Lancet - Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study. The story was covered in most UK national papers and also on websites around the world.
Year(s) Of Engagement Activity 2019
 
Description STEM ambassador: Science talk to A-level students. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Pupils attended a talk at a local high school to promote science as a career as part of the researchers STEM ambassador role. The talk sparked questions and discussion afterwards.
Year(s) Of Engagement Activity 2019
 
Description Schott and Keshavan, AAIC Los Angeles (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Jonathan Schott and Dr Ashvini Keshavan were invited to present a featured research session at AAIC 2019 in Los Angeles on the following topic: "The 1946 birth cohort - relationships between cerebral amyloid pathology using two independent methods for plasma amyloid beta measurement."
Year(s) Of Engagement Activity 2019
 
Description Schott, AAIC Los Angeles (2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Jonathan Schott gave a presentation at AAIC 2019 in Los Angeles entitled, "Two Independent Methods for Plasma Amyloid Beta Measurement."
Year(s) Of Engagement Activity 2019
 
Description Science Museum Lates 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact LHA took their Life Course Golf Course activity to the Science Museum Lates. Participants were taken round the miniature golf course by our researchers (the caddy) and learnt about our longitudinal research into healthy ageing
Year(s) Of Engagement Activity 2019
 
Description Stand at UCL Alzheimer's Research UK public engagement festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We had a stand at this event to promote the cognitive research the unit carries out by providing information to the general public and letting them play educational games to learn more about it. People took leaflets and engaged with the scientists by asking questions.
Year(s) Of Engagement Activity 2019