Mental Ageing
Lead Research Organisation:
UNIVERSITY COLLEGE LONDON
Department Name: UNLISTED
Abstract
Mental ageing refers to change or stability in later life cognition (i.e. knowing, learning and reasoning) and emotion (i.e. anxiety, depression and positive wellbeing). These processes are fundamental to our health, everyday life, and survival; which is why impairments in these functions are the biggest cause of disability in the UK.
Our aim is to investigate influences in these functions across the life course, and the consequences of this for daily living and other aspects of health. To achieve this we will study three themes. First, we will investigate cognitive and emotional resilience, i.e. good (or good enough) function in spite of adversity. Second, we will investigate cognitive and emotional function in relation to cardiovascular (i.e. heart and blood vessel) function; this is important because most of the modifiable risks we know about for dementia are cardiovascular in nature, particularly in midlife. Third, we will investigate the life course epidemiology of emotional function. Of particular interest here is whether depression becomes more or less common in later life, and if so, what factors across the life course determine that change in risk.
Our aim is to investigate influences in these functions across the life course, and the consequences of this for daily living and other aspects of health. To achieve this we will study three themes. First, we will investigate cognitive and emotional resilience, i.e. good (or good enough) function in spite of adversity. Second, we will investigate cognitive and emotional function in relation to cardiovascular (i.e. heart and blood vessel) function; this is important because most of the modifiable risks we know about for dementia are cardiovascular in nature, particularly in midlife. Third, we will investigate the life course epidemiology of emotional function. Of particular interest here is whether depression becomes more or less common in later life, and if so, what factors across the life course determine that change in risk.
Technical Summary
Aim
We will investigate the life course causes and consequences of mental ageing, with regard to cognitive and psychological states and their change.
Background
Mental ageing is fundamental to almost all major life outcomes, including other aspects of health, social relationships, economic security, independent living, and survival. Thus, impairments in cognitive and psychiatric state are, in combination, the biggest cause of disability in the UK.
Methods
This programme will be centred on the MRC National Survey of Health and Development (NSHD, the British 1946 birth cohort), requiring complex longitudinal and trans-system modelling; and on DELPHIC (acute stress).
Objectives
To investigate cognitive and mental resilience to acute and chronic stressors
To investigate mental ageing in regard to cerebrovascular health
To investigate the life course epidemiology of depression
We will investigate the life course causes and consequences of mental ageing, with regard to cognitive and psychological states and their change.
Background
Mental ageing is fundamental to almost all major life outcomes, including other aspects of health, social relationships, economic security, independent living, and survival. Thus, impairments in cognitive and psychiatric state are, in combination, the biggest cause of disability in the UK.
Methods
This programme will be centred on the MRC National Survey of Health and Development (NSHD, the British 1946 birth cohort), requiring complex longitudinal and trans-system modelling; and on DELPHIC (acute stress).
Objectives
To investigate cognitive and mental resilience to acute and chronic stressors
To investigate mental ageing in regard to cerebrovascular health
To investigate the life course epidemiology of depression
Organisations
- UNIVERSITY COLLEGE LONDON (Lead Research Organisation)
- Alliance Medical (Collaboration)
- University of Glasgow (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- Stony Brook University (Collaboration)
- University of Portsmouth (Collaboration)
- Lund University (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Institute of Mental Health (Collaboration)
- UNIVERSITY OF ABERDEEN (Collaboration)
- Stanford University (Collaboration)
- Chinese University of Hong Kong (Collaboration)
- London School of Economics and Political Science (University of London) (Collaboration)
- University College London (Collaboration)
- Leiden University (Collaboration)
- Newcastle University (Collaboration)
- University of Bristol (Collaboration)
- CARDIFF UNIVERSITY (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- Tokyo Metropolitan Institute of Medical Science (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- University of Sussex (Collaboration)
- OXFORD BROOKES UNIVERSITY (Collaboration)
- SWANSEA UNIVERSITY (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Almeida-Meza P
(2022)
Moderating Role of Cognitive Reserve Markers Between Childhood Cognition and Cognitive Aging: Evidence From the 1946 British Birth Cohort.
in Neurology
Anderson EL
(2022)
Little genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers.
in Scientific reports
Archer G
(2020)
Association Between Lifetime Affective Symptoms and Premature Mortality.
in JAMA psychiatry
Bakolis I
(2023)
Area disadvantage and mental health over the life course: a 69-year prospective birth cohort study.
in Social psychiatry and psychiatric epidemiology
Bauermeister S
(2020)
The Dementias Platform UK (DPUK) Data Portal.
in European journal of epidemiology
Bell G
(2024)
Predictors of primary care psychological therapy outcomes for depression and anxiety in people living with dementia: evidence from national healthcare records in England.
in The British journal of psychiatry : the journal of mental science
Bell G
(2022)
Positive psychological constructs and cognitive function: A systematic review and meta-analysis
in Ageing Research Reviews
| Description | Alzheimer's Research UK Brain Health consensus statement |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://www.alzheimersresearchuk.org/about-us/our-influence/policy-work/risk-reduction/ |
| Description | House of Lords Select Committee on Healthy Ageing |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://www.parliament.uk/business/committees/committees-a-z/lords-select/science-and-technology-com... |
| Description | Science Question Time even organised by Collider Health and Collider Science/Longevity International- Secretariat for All Party Parliamentary Group for Longevity |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Workshop on Research Definitions for Reserve and Resilience |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Took part in 2nd workshop on Research Definitions for Reserve and Resilience this week with over 200 attendees from around the world. Improved understanding and shared use of researhc definitions. |
| Description | Detecting and monitoring dementia using dynamic digital biomarkers of night-time behaviour and sleep. |
| Amount | £1,509,552 (GBP) |
| Funding ID | NIHR204286 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 02/2026 |
| Description | Inspire Award |
| Amount | £15,000 (GBP) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 05/2020 |
| Description | Investigating the mechanisms linking psychiatric disorders with subsequent cognitive decline and dementia: a triangulation approach using causal inference methods |
| Amount | £338,838 (GBP) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 04/2028 |
| Description | Retirement and mental health: Heterogeneity and cross-country comparisons |
| Amount | £66,317 (GBP) |
| Organisation | Understanding Society |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2024 |
| End | 12/2024 |
| Description | Risk and resilience small grant |
| Amount | £10,349 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 02/2021 |
| Description | Understanding Society Fellowship: Quantifying The Longitudinal Impacts Of Racial Discrimination On The Mental Health Of Ethnic Minority Children And Families Across UK Households |
| Amount | £43,844 (GBP) |
| Organisation | Understanding Society |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 12/2023 |
| Title | 1970 British Cohort Study Response Dataset, 1970-2016 |
| Description | The 1970 British Cohort Study (BCS70) began in 1970 when data were collected about the births and families of babies born in the United Kingdom in one particular week in 1970. Since then, there have been nine further full data collection exercises in order to monitor the cohort members' health, education, social and economic circumstances. These took place when respondents were aged 5 in 1975, aged 10 in 1980, aged 16 in 1986, aged 26 in 1996, aged 30 in 1999-2000 (SN 5558), aged 34 in 2004-2005, aged 42 in 2012 and aged 46 in 2016-18. A range of sub-sample and supplementary surveys have also been conducted, and a separate dataset covering response to BCS70 over all waves is available under SN 5641, 1970 British Cohort Study Response Dataset, 1970-2012. Further information about the BCS70 and may be found on the Centre for Longitudinal Studies website. As well as BCS70, the CLS now also conducts the NCDS series. How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) website. The BCS70 Response Dataset contains response outcomes for all main sweeps of BCS70 (1970-2016). The fourth edition (March 2021) includes Sweep 10 outcomes and has been streamlined by removing cases which have never participated in any main sweep survey and are no longer being issued. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/1970-british-cohort-study/ |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=5641#2 |
| Title | Additional file 1 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 1: Supplementary file 1: Table 1. Full hub metabolite results (models 1-3). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Investigating_associations... |
| Title | Additional file 1 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 1: Supplementary file 1: Table 1. Full hub metabolite results (models 1-3). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Investigating_associations... |
| Title | Additional file 2 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 2: Supplementary file 2: Table 2. Full module analysis results (models 1-3). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Investigating_associations... |
| Title | Additional file 2 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 2: Supplementary file 2: Table 2. Full module analysis results (models 1-3). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Investigating_associations... |
| Title | Additional file 3 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 3: Supplementary file 3: Table 3. PRS results. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Investigating_associations... |
| Title | Additional file 3 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 3: Supplementary file 3: Table 3. PRS results. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Investigating_associations... |
| Title | Additional file 4 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 4: Supplementary file 4: Table 4. Associations between metabolites, modules, outcomes and lifestyle factors. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_4_of_Investigating_associations... |
| Title | Additional file 4 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 4: Supplementary file 4: Table 4. Associations between metabolites, modules, outcomes and lifestyle factors. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_4_of_Investigating_associations... |
| Title | Additional file 5 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 5: Supplementary file 5: Table 5. Associations between metabolites and modules and whole-brain volume following adjustment for smoking and alcohol intake. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_5_of_Investigating_associations... |
| Title | Additional file 5 of Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease |
| Description | Additional file 5: Supplementary file 5: Table 5. Associations between metabolites and modules and whole-brain volume following adjustment for smoking and alcohol intake. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_5_of_Investigating_associations... |
| Title | Covid 19 questionnaire dataset |
| Description | NSHD study members were sent upto three online/postal questionnaires on COVID. In the first questionnaire, a variety of questions were asked to capture a physical and mental health and wellbeing, family and relationships, education, work, and finances during the first national lockdown. In the second questionnaire, we repeated many of the topic areas as in Wave 1, but included questions on health care, financial transfer and life events. For the third questionnaire, we additionally asked about the vaccination programme and long COVID. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Too early to say - numerous publications and impacts will be produced using these data in the future |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/studies/study?id=8732 |
| Title | Data Partner on Global Azheimer's Association Interactive Network |
| Description | Insight 46 is now a Data Partner with the Global Alzheimer's Association Interactive Network (GAAIN). Some Insight 46 variables are available to explore using the GAAIN Interrogator, which allows reserachers to explore large cohorts of Alzheimer's disease subjects across attributes from GAAIN data partners. Examples of those variables include: biological (blood, urine, CSF); genetic (apoE); participant characteristics (sex, education, handedness); neuropsychology scores ( Logical Memory - Immediate and Delayed, Digit Symbol Substitution, Matrix Reasoning, Preclinical Alzheimer Cognitive Composite [PACC]); clinical (AD8, CDR, MMSE, mild cognitive impairment, dementia consensus); MRI (regional and whole brain volumes); and amyloid PET (SUVRs, positive/negative) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Allows NSHD data to be explored be international researchers. |
| URL | https://www.gaaindata.org/partner/INSIGHT46 |
| Title | Geography and Longitudinal Data: Understanding Society The UK Household Longitudinal Study |
| Description | Understanding Society is the largest longitudinal study of its kind and provides crucial information for researchers and policymakers on the changes and stability of people's lives in the UK. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | https://www.understandingsociety.ac.uk/research/impact |
| URL | http://rgdoi.net/10.13140/RG.2.2.15806.54089 |
| Title | Insight 46 data collection - Phase 1 (2015 - 2018) |
| Description | First phase of data collection for Insight 46 phase 1 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Many publications, conference papers and presentations, and continued data collection |
| URL | https://www.ucl.ac.uk/drc/research-clinical-trials/insight-46 |
| Title | Insight 46 data collection - Phase 2 (2018 - 2021) |
| Description | Second phase of data collection for Insight 46 phase 2 (2018 - 2021) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Continued data collection for Insight 46, several publications and conference posters and presentations, led to additional funding for a third phase of data collection |
| URL | https://www.ucl.ac.uk/drc/research-clinical-trials/insight-46 |
| Title | Insight 46 data collection - Phase 3 (2021 - ongoing) |
| Description | Ongoing data collection for Insight 46 phase 3 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | Insight 46 phase 3 data collection is ongoing. Although the data are not yet available externally, they will be available to bonafide researchers one year after study completion. Data are available to internal UCL teams for use in conference abstracts. |
| URL | https://www.ucl.ac.uk/drc/research-clinical-trials/insight-46 |
| Title | MRC NSHD 2013-2018 Data |
| Description | The MRC National Survey of Health and Development (NSHD) has informed UK health care, education and social policy for more than 50 years and is the oldest and longest running of the British birth cohort studies. Today, with study members in their seventies, the NSHD offers a unique opportunity to explore the long-term biological and social processes of ageing and how ageing is affected by factors acting across the whole of life. From an initial maternity survey of 5362 births recorded in England, Scotland and Wales during one week of March 1946, a socially stratified sample of singleton babies born to married parents was selected for follow-up. These participants have been studied over twenty times throughout their life. During their childhood, the main aim of the NSHD was to investigate how the environment at home and at school affected physical and mental development and educational attainment. During adulthood, the main aim was to investigate how childhood health and development and lifetime social circumstances affected their adult health and function and their change with age. Now, as participants have reached retirement, the research team is developing the NSHD into a life course study of ageing. Study members were asked to attend a clinic at age 60-64 for a range of assessments (or alternatively have a home visit). They were invited for a home visit at 69 years, updating information on health, lifestyle and life circumstances as well as obtaining repeat physical and cognitive measurements. Postal questionnaires were completed before the clinic and home visits. A subset of 500 study members are also being invited to participate in a Neuroscience sub-study. This publication covers data from the NSHD for the years 2013 to 2018. The cohort study is ongoing and further data collections are being added, while component data sets are separately referable. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Data provided for linkage within UK LLC |
| URL | http://www.nshd.mrc.ac.uk/data/nshd-digital-object-identifiers/mrc-nshd-2013-2018-data/ |
| Title | Millennium Cohort Study |
| Description | Socio-emotional behaviours in early childhood, including self-regulation, emotional problems, and peer problems, have been shown to individually influence academic achievement in primary and secondary school. Environmental and demographic factors have also been shown to influence a child's academic development. The current study extends previous work to consider - concurrently, using structural equation modelling - a broader array of antecedents and measures of social-emotional development to understand their relative effects on academic outcomes. Parent-report data on a nationally representative sample of children (n = 17,035) at ages 3 and 5 years, and academic assessment at age 7, were drawn from the Millennium Cohort Study for longitudinal modelling. Results indicate the individual and collective contribution of socio-emotional, environmental, and demographic antecedents, expanding the current literature on predictors of child academic achievement in primary school. The results suggest that malleable factors in early childhood are important predictors of later academic success, and thus may be viable targets for intervention. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/millennium-cohort-study/ |
| URL | http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/36952/version/1 |
| Title | National Child Development Study: Activity Histories, 1974-2013 |
| Description | The National Child Development Study (NCDS) originated in the Perinatal Mortality Survey (see SN 5565), which examined social and obstetric factors associated with still birth and infant mortality among over 17,000 babies born in Britain in one week in March 1958. Surviving members of this birth cohort have been surveyed on eight further occasions in order to monitor their changing health, education, social and economic circumstances - in 1965 at age 7, 1969 at age 11, 1974 at age 16 (the first three sweeps are also held under SN 5565), 1981 (age 23 - SN 5566), 1991 (age 33 - SN 5567), 1999/2000 (age 41/2 - SN 5578), 2004-2005 (age 46/47 - SN 5579), 2008-2009 (age 50 - SN 6137) and 2013 (age 55 - SN 7669). There have also been surveys of sub-samples of the cohort, the most recent occurring in 1995 (age 37), when a 10% representative sub-sample was assessed for difficulties with basic skills (SN 4992). Finally, during 2002-2004, 9,340 NCDS cohort members participated in a bio-medical survey, carried out by qualified nurses (SN 5594, available under more restrictive Special Licence access conditions; see catalogue record for details). The bio-medical survey did not cover any of the topics included in the 2004/2005 survey. Further NCDS data separate to the main surveys include a response and deaths dataset, parent migration studies, employment, activity and partnership histories, behavioural studies and essays - see the NCDS series page for details. Further information about the NCDS can be found on the Centre for Longitudinal Studies website. How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: A useful overview of the governance routes for applying for genetic and bio-medical sample data, which are not available through the UK Data Service, can be found at Governance of data and sample access on the METADAC (Managing Ethico-social, Technical and Administrative issues in Data Access) website. The purpose of the National Child Development Study: Activity Histories, 1974-2013 was to merge all data on work and non-work activities in successive sweeps into one longitudinal dataset. Data on work and non-work activities lasting one month or more have been collected in all NCDS sweeps from sweep 4 (age 23) onwards. The focus of the questions asked at each sweep vary from: work activities engaged in since leaving school (sweep 4 aged 23); work and non-work activities engaged in since leaving school (sweep 5, aged 33); work and non-work activities engaged in since the last sweep (sweep 6, aged 42); work and non-work activities engaged in since the last sweep or aged 16 (sweep 7, aged 46) work and non-work activities engaged in since 2000, or 2004 if included in sweep 7 (sweep 8, aged 50), work and non-work activities engaged in since 2004, or 2008 if included in sweep 8 (sweep 9, aged 55). Therefore the activity histories will start from the time that the cohort member left school and continue until the interview date of the latest data sweep that each cohort member participated in. The lengths of the activity histories vary depending on the latest sweep that a cohort member was present at. The minimum activity history length recorded is 1 month and the maximum is 480 months (40 years). Gaps in the activity histories occur where a cohort member has not been present at all sweeps and/or where full activity data were not reported. An employment histories dataset was previously created (Ward, 2007). This work was undertaken as part of the Gender Network Project. The current work on NCDS activity histories builds on this previous activity history and incorporates various cleaning of the data. This previous employment history included data up to sweep 7 (2004) only, did not deal with any non-work activities and did not identify duplicate activities (i.e. where an activity was reported again in a later sweep). Latest Edition Information For the second edition (June 2016) the data and documentation were updated to include the latest NCDS wave, extending coverage to 2013. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | https://cls.ucl.ac.uk/cls-studies/1958-national-child-development-study/ |
| URL | https://beta.ukdataservice.ac.uk/datacatalogue/doi/?id=6942#3 |
| Title | SABRE |
| Description | a UK population-based comparison of cardiovascular disease and diabetes in people of European, South Asian and African Caribbean heritage |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Currently, and in the past, supported many research studies aiding hundreds of publications around the world. |
| URL | https://portal.dementiasplatform.uk/CohortDirectory/Item?fingerPrintID=SABRE |
| Title | TwinsUK |
| Description | The TwinsUK resource is the biggest UK adult twin registry of 12.000 twins used to study the genetic and environmental aetiology of age related complex traits and diseases. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | https://twinsuk.ac.uk/media-and-engagement/overview/ |
| URL | http://service.re3data.org/repository/r3d100011851 |
| Title | Understanding Society Ethnic Minority Family Matrix |
| Description | This dataset is a link of the ethnic minority boost sample and family matrix datasets, cleaned such that researchers can easily study familial relationships for ethnic minority participants of USOC, both within and between households |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Pending Publication on Understanding Society Website |
| Description | Blood biomarkers |
| Organisation | Lund University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Collaborating on a biomarker identification and characterisation project |
| Collaborator Contribution | Collaborating on a biomarker identification and characterisation project |
| Impact | Publications |
| Start Year | 2022 |
| Description | Chinese University of Hong Kong |
| Organisation | Chinese University of Hong Kong |
| Country | Hong Kong |
| Sector | Academic/University |
| PI Contribution | Provide cognition and mental health expertise. Advising on analysis and manuscript preparation. |
| Collaborator Contribution | Data analysis and manuscript preparation. |
| Impact | PMID: 27807316 Lee AT, Chan WC, Chiu HF, Richards M, Hui LY, Ng SP, Chan WM, Lam LC. Physical health and lifestyle predictors for significant cognitive impairment in community-dwelling Chinese older adults in Hong Kong. Hong Kong Med Journal, 2016, 22 Suppl 6, 37-39. Lee A, Richards M, Chan Wai C, Chiu H, Lee R, Lam L. Lower risk of incident dementia among older adults having 3 servings of vegetables and 2 servings of fruits a day. PMID:28338708 Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW. Association of Daily Intellectual Activities With Lower Risk of Incident Dementia Among Older Chinese Adults. JAMA Psychiatry. 2018;75(7):697-703. doi:10.1001/jamapsychiatry.2018.0657 Lee A, Richards M, Chan WC, Chiu H, Lee R, Lam L. Higher dementia incidence in older adults with type 2 diabetes and large reduction in HbA1c. Age and Ageing 2019, 48, 838-844.PMID: 31574142 |
| Start Year | 2016 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Nutrition Research Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Lifecourse Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | University College London |
| Department | Institute of Education (IOE) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaborating with HALCyon cohorts |
| Organisation | University of Portsmouth |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing research expertise |
| Collaborator Contribution | data sharing and research expertise |
| Impact | Numerous research papers including 23818103 |
| Start Year | 2008 |
| Description | Collaboration with Alliance Radiopharmaceuticals |
| Organisation | Alliance Medical |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | None |
| Collaborator Contribution | Alliance Medical has provided doses of Florbeteben in kind to be used as part of Insight 46 pahse 3. |
| Impact | Details of Insight 46 phase 3 are described in: Murray-Smith et al. 2024. Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3. BMC Neurol. Jan 23;24(1):40. |
| Start Year | 2021 |
| Description | Collaboration with Imperial College London - Cognitron |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration between Prof Adam Hampshire at Imperial College London to administer Cognitron online cognitive test to NSHD cohort. UCL was resposible for the distrbution of the online test to the NSHD cohort. |
| Collaborator Contribution | Imperial College London provided the infrastructure for the data collection and created the Cognitron online platform. |
| Impact | Ongoing data analysis, two abstracts submitted to AAIC 2024 |
| Start Year | 2022 |
| Description | Collaboration with Imperial College London - Sleep mats in Insight 36 |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sleep mats have been incorporated into the data collection for Insight 46. UCL are deploying the sleep mats within the NSHD cohort members who have taken part in multiple phases of Insight 46. |
| Collaborator Contribution | Imperial College London are providing the bed mats to be used int his project and initial data analyses. |
| Impact | Data collection ongoing |
| Start Year | 2023 |
| Description | Collaboration with Japanese Study Group |
| Organisation | Tokyo Metropolitan Institute of Medical Science |
| Department | Department of Psychiatry & Behavioral Science |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | NSHD data sharing Housing two researchers at LHA for a period of 12 months. One in 2013-14 and one in 2014-15. Provide advice on the project to do with mental health and aspects of personality To build the collaborative relationship between MRC Unit for Lifelong Health and Aging and the Tokyo Teen Cohort Project. |
| Collaborator Contribution | 1. To seek the key factors which affecting the development of self-regulation in adolescence by using the data from the 1946 British Birth Cohort Study. 2. To investigate a range of health outcomes in relation to discrepancies between verbal and non-verbal cognitive function in NSHD specifically work on social outcomes in those with dyslexia in the NSHD. 3. To learn the management methodology of long-term birth cohort study by committing your current research (MRI study) of the 1946 British Birth Cohort Study. 3. To build the collaborative relationship between MRC Unit for Lifelong Health and Aging and our Tokyo Teen Cohort Project. |
| Impact | A research fellow will be visiting LHA for 12 months to work on NSHD data. Another researcher will be visiting the Unit for 12 months in March 2014. PMID 24714378 Nishida et al PMID 25315221 Nishida et al PMID 26752724 Nishida et al PMID 26449420 Koike et al Adolescent self control behavior predicts body weight through the life course: a prospective birth cohort study. PMID 27279898 Nishida Endo K 2017, Preference for Solitude, Social Isolation, Suicidal Ideation, and Self-Harm in Adolescents.PMID: 28457686 Koike S 2017, Cognitive profiles in childhood and adolescence differ between adult psychotic and affective symptoms: a prospective birth cohort study. Psychol Med. 2017 Oct 9:1-12. PMID:28988550 PMC5729848. Koike S 2018, Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: a prospective birth cohort study. PMID: 29331705 Koike S, Richards M, Wong A, Hardy R. Fat Mass and Obesity Associated (FTO) rs9939609 Polymorphism Modifies the Relationship between body mass index and Affective Symptoms through the Life Course: a prospective birth cohort study. Translational Psychiatry 2018 Mar 13;8(1):62. doi: 10.1038/s41398-018-0110-1. Morimoto Y, Yamasaki S, Ando S, Koike S, Fujikawa S, Kanata S, Endo K, Nakanishi M, Hatch S, Richards M, Kasai K, Hiraiwa-Hasegawa M, Nishida A. Purpose in life and tobacco use among community-dwelling mothers of early adolescents. BMJ Open 2018 Apr 20;8(4):e020586. doi: 10.1136/bmjopen-2017-020586. Nakanishi M, Yamasaki S, Endo K, Ando S, Morimoto Y, Fujikawa S, Kanata S, Takahashi Y, Furukawa TA, Richards M, Hiraiwa-Hasegawa M, Kasai K, Nishida A. The association between role model presence and self-regulation in early adolescence: A cross-sectional study. PMID: 31536579 Nakanishi M, Yamasaki S, Nishida A, Richards M. Midlife Psychological Well-being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort. J Alzheimers Dis. 2019 Oct 17. doi: 10.3233/JAD-190590. [Epub ahead of print] PMID: 31640097 |
| Start Year | 2012 |
| Description | Collaboration with Lund Univesrity |
| Organisation | Lund University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | UCL provided the blood and CSF samples for analysis |
| Collaborator Contribution | Lund University are analysing the blood and CSF samples for ptau217 |
| Impact | data analysis ongoing |
| Start Year | 2023 |
| Description | Collaboration with Stanford University |
| Organisation | Stanford University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | UCL provided blood and CSF samples for analysis |
| Collaborator Contribution | Stanford University analysed the blood and CSF samples for proteomic profiles |
| Impact | data analysis ongoing |
| Start Year | 2023 |
| Description | Collaboration with Uni of West Sussex/Leiden |
| Organisation | Leiden University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers. |
| Collaborator Contribution | We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers. |
| Impact | Xu PMID: 26125156 Gaysina PMID: 26439078 PhD supervision ET Secinti E 2017. Research Review: Childhood chronic physical illness and adult emotional health - a systematic review and meta-analysis. PMID: 28449285. Xu MK 2017. Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. PMID:29075213 |
| Start Year | 2014 |
| Description | Collaboration with Uni of West Sussex/Leiden |
| Organisation | University of Sussex |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers. |
| Collaborator Contribution | We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers. |
| Impact | Xu PMID: 26125156 Gaysina PMID: 26439078 PhD supervision ET Secinti E 2017. Research Review: Childhood chronic physical illness and adult emotional health - a systematic review and meta-analysis. PMID: 28449285. Xu MK 2017. Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. PMID:29075213 |
| Start Year | 2014 |
| Description | Collaborations on cognitive ageing NES |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Ongoing collabroation on LHA/NSHD Cognitive ageing programme. Scientific leads on study design and drafting manuscripts vary, involves data sharing, analysis, interpretation and revision of manuscripts. |
| Collaborator Contribution | Experitise in cognitive ageing |
| Impact | Richards et al 2009 (with Batty) Richards et al Lifetime Antecedents of cognitive reserve. In Stern Y (ed). Cognitive Reserve. New York: Psychology Press Hatch et al 2007 17397976 18079429 18718979 Richards, M., Sacker, A., Deary, I.J. (2006) Lifetime antecedents of cognitive reserve. In Stern. Y. (ed.) Cognitive Reserve. Psychology Press, New York. Richards, M. (2006) Do heavier babies make brighter children? In Murray, R., McCabe, J., McGuffin, P., O'Daly, O. and Wright, P. (eds). Beyond nature and nurture: genes, environment and their interplay in psychiatry. Martin Dunitz. Denier N, Clouston SAP, Richards M, Hofer SM. Retirement and cognition: A life course view. Advances in Life Course Research 2017, 31, 11-21. Clouston S, Kotov R, Pietrzak R, Luft B. Gonzalez A, Richards M, Ruggero C, Spiro A, Bromet E. Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. Alzheimer's & Dementia: Diagnosis, Assessment and Disease Monitoring, 2016, 4, 67-75. Kate Xu paper parental bonding instrument PMID 27485970 Received back data set from Kate Xu Secinti E, Thompson EJ, Richards M, Gaysina D. Childhood chronic physical illness and adult emotional health: a systematic review and meta-analysis. In press: Journal of Child Psychology and Psychiatry. 2017 Jul;58(7):753-769. PMID: 28449285. PMID 24598045 Horvat et al PMID 24357571Richards et al PMID 24482683 Silverwood et al PMID 25001968 Gaysina et al PMID 23178897 Gaysina et al Clouston PMID: 27940567 A life course approach to health literacy: The role of gender, educational attainment, and lifetime cognitive capability Denier o Denier N, Clouston SAP, Richards M, Hofer SM. Retirement and cognition: A life course view. Advances in Life Course Research 2017, 31, 11-21. Clouston PMID: 27626057 Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. .Xu MK, Gaysina D, Tsonaka R, Morin AJS, Croudace TJ, Barnett JH, Houwing-Duistermaat J, Richards M, Jones PB; LHA Genetics Group. Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. Front Psychol. 2017 Oct 11;8:1736. PMID:29075213 Clouston SAP, Smith DM, Mukherjee S, Zhang Y, Hou W, Link BG, Richards M. Education and cognitive decline: An integrative analysis of global longitudinal studies of cognitive aging. J Gerontol B Psychol Sci Soc Sci. 2019 May 6. pii: gbz053. doi: 10.1093/geronb/gbz053. [Epub ahead of print] PMID: 31059564 Clouston S, Diminich E, Kotov R, Pietrzak R, Richards M, Spiro A, Deri Y, Carr M, Yang X, Gandy S, Sano M, Bromet E, Luft B. Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events of 9/11/2001. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2019, 11, 628-636 |
| Start Year | 2020 |
| Description | Collaborations on mental health NES |
| Organisation | King's College London |
| Department | Institute of Psychiatry, Psychology & Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers. |
| Collaborator Contribution | Development of LHA/NSHD mental health research programme |
| Impact | Publications (not otherwise specified under other collaborations involving these collaborators): Richards M, Goldberg D. Are there early adverse exposures that differentiate depression and anxiety risk? In: Goldberg D, Kendler KS, Sirovatka P, Regier DA (eds). Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V. Arlington, VA: American Psychiatric Association 19131382 19379961 18827297 18295901 17976252 17692292 17202554 17487877 16777388 16880486 16734949 16393365 18378866 PMID 25066933 Colman et al PMID 24357583 Byford PMID 26835144 Tikhonoff New award, with Richards as co-investigator: Harmonisation of mental health measures in British birth cohorts. (PI: G Ploubidis, UCL). ESRC. June 2018-July 2019. Total value: £72,918.80 New Award Co-investigator: Assessment and harmonisation of cognitive measures in British birth cohorts (PI: Vanessa Moulton, UCL). ESRC. July 2018-June 2019. Total value: £67,265.00. |
| Start Year | 2006 |
| Description | Collaborations on mental health NES |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have an ongoing scientific collaboration with key NSHD collaborators in these 2 groups. Scientific lead for study design for a particular project can vary. Involves doctoral or post doctoral supervision, NSHD data sharing, analysis, interpretation, drafting and revising of papers. |
| Collaborator Contribution | Development of LHA/NSHD mental health research programme |
| Impact | Publications (not otherwise specified under other collaborations involving these collaborators): Richards M, Goldberg D. Are there early adverse exposures that differentiate depression and anxiety risk? In: Goldberg D, Kendler KS, Sirovatka P, Regier DA (eds). Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V. Arlington, VA: American Psychiatric Association 19131382 19379961 18827297 18295901 17976252 17692292 17202554 17487877 16777388 16880486 16734949 16393365 18378866 PMID 25066933 Colman et al PMID 24357583 Byford PMID 26835144 Tikhonoff New award, with Richards as co-investigator: Harmonisation of mental health measures in British birth cohorts. (PI: G Ploubidis, UCL). ESRC. June 2018-July 2019. Total value: £72,918.80 New Award Co-investigator: Assessment and harmonisation of cognitive measures in British birth cohorts (PI: Vanessa Moulton, UCL). ESRC. July 2018-June 2019. Total value: £67,265.00. |
| Start Year | 2006 |
| Description | Computational Platform for Assessment of Cognition In Dementia (C-PLACID) - UCL |
| Organisation | University College London |
| Department | Institute of Neurology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide cognitive ageing expertise |
| Collaborator Contribution | The overall objectives of this project are to: - Enhance the cognitive assessment of people with dementia through computational, mathematical and engineering innovation. - Develop a computational platform that will support substantial improvements in the analysis and visualisation of complex cognitive datasets, and the automatization, optimization and innovation of techniques and devices used to acquire cognitive data. The specific objectives are to: - Generate multivariate cognitive profiles in different dementias. - Create algorithms to predict the evolution of cognitive events, particularly in rare and atypical dementias. - Improve existing tests through the automatic measurement of voice reaction times and implementation of psychophysical principles. - Enhance existing cognitive assessment paradigms by utilizing eyetracking. - Develop novel 'instruction-less' tests of cognition suitable for patients with different types and severities of dementia. - Build novel sensors of participant reactions to complex social and other scenarios. - Use virtual reality to evaluate social cognition in fronto-temporal dementia. |
| Impact | EPSRC Sensing and Imaging for the Diagnosis of Dementia grant awarded to Institute of Neurology. The eye-tracking component of this is now embedded within wave 2 of Insight 46 |
| Start Year | 2014 |
| Description | Haggarty Epigenetics Aberdeen |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on imprinting methylation; early life influences and later cognition and mood |
| Collaborator Contribution | Collaboration on imprinting methylation; early life influences and later cognition and mood |
| Impact | First Joint meeting 10th March 2016 Lorgen-Ritchie M, Murray AD, Ferguson-Smith AC, Richards M, Horgan GW, Phillips LH, Hoad G, Gall I, Harrison K, McNeill G, Ito M, Haggarty P. Imprinting methylation in SNRPN and MEST1 in blood predicts cognitive ability. PLoS One 2019 Feb 1;14(2):e0211799. doi: 10.1371/journal.pone.0211799. eCollection 2019. Erratum in: PLoS One 2019 Apr 10;14(4):e0215422. |
| Start Year | 2015 |
| Description | IOE - GP |
| Organisation | University College London |
| Department | Institute of Education (IOE) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data preparation, analysis, expertise advice, manuscipt preparation, grant applciations, data collection plans. |
| Collaborator Contribution | Data preparation, analysis, expertise advice, manuscipt preparation, grant applciations, data collection plans. |
| Impact | Psychological distress from early adulthood to early old age: evidence from the 1946, 1958 and 1970 British birth cohorts. Gondek D, Bann D, Patalay P, Goodman A, McElroy E, Richards M, Ploubidis GB. Psychol Med. 2021 Jan 21:1-10. doi: 10.1017/S003329172000327X. Online ahead of print. PMID: 33472020 |
| Start Year | 2019 |
| Description | Insight 46 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Cognition and Brain Sciences Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaborating with colleagues at the UCL MRC National Survey for Health and Development, Institute of Molecular Neuroscience, and Institute of Nuclear Medicine, Insight 46 is a major prospective two-time point (0, 12m) MRI, amyloid PET, clinical, biomarker and neuropsychological study of 500 members of the MRC National Survey for Health and Development 1946 birth cohort. This highly inter-disciplinary study involving UCL based epidemiologists, neurologists, imagers, clinical chemists, geneticists and statisticians aims to determine the earliest biomarker changes of AD, the contribution of genetic and life course influences on the development of late life cognitive impairment, and the optimal means of designing AD prevention studies. This >£5M project includes funding from ARUK, MRC Dementias Platform UK (WP4), Wolfson Foundation and Brain Research Trust, as well as industry contributions (~£850K, Eli Lilly). As well as coordinating the project (with Fox, Richards) I supervise a study manager, two clinical PhD students (Lane and Parker, a Wellcome Training Fellowship), and a study coordinator. The study is well underway, with >300 scaned; cross-sectional data will complete in October 2017; and longitudinal collection two years later. |
| Collaborator Contribution | N/A |
| Impact | N/A |
| Start Year | 2014 |
| Description | Insight 46 Study |
| Organisation | University College London |
| Department | Institute of Neurology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A subset of study members from NSHD will undergo positron emission tomography (PET) to detect early deposition of fibrillar beta-amyloid (Aß) and other misfolded proteins involved in the pathogenesis of Alzheimer's disease; (2) sensitive MRI techniques to measure early cortical and sub-cortical atrophy, cerebrovascular lesions, cerebral blood flow, and regional metabolic rate of oxygen. NSHD will coordinate the study and review the potential to add in additional assessments (auditory and visual) around this sub-study |
| Collaborator Contribution | The PET scans and MRI techniques will be carried out by collaborators at Queens Square. They will also interpret the scans. Our collaborators are also helping the initial organisation/logistics of the study. |
| Impact | Funding from the Wolfson Foundation for a neuroimaging sub-study for 500 NSHD study members Grant application submitted but not successful to Welcome Trust Funding from ARUK for 3 day study manager and 1 day of senior study manager (128,000) Training, equipment and documents purchased/created Abstracts submitted to Alzheimer's Association International Conference, May 2017. 500 participants seen and wave 1 has been completed. Wave 2 is underway. Lane CA, Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development.BMC Neurol. 2017 Apr 18;17(1):75. doi: 10.1186/s12883-017-0846-x. PMID:28420323 James SN, Lane CA, Parker TD, Lu K, Collins JD, Murray-Smith H, Byford M, Wong A, Keshavan A, Buchanan S, Keuss SE, Kuh D, Fox NC, Schott JM, Richards M. Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46. BMC Res Notes. 2018 Dec 13;11(1):885. doi: 10.1186/s13104-018-3995-0. PMID: 30545411 Lane C, Parker T, Macpherson K, Murray-Smith H, Cash D, Thomas D, Byford M, Wong A, Modat M, Malone I, Klimova J, Burgos N, Hutel M, Melbourne A, Donnachie E, Esser P, Dawes H, Husain M, Hoskote C, Shah S, + others, Frost C, Hardy R, Bras J, Hardy J, Zhang H, Zetterberg H, Ourselin S, Sharma N, Crutch SJ, Kuh D, Richards M*, Fox NC*, Schott JM* (joint senior). Study Protocol: Insight 46, a neuro-imaging sub-study of the MRC National Survey for Health and Development 1946 Birth cohort. BMC Neurology 2017 Apr 18;17(1):75. doi: 10.1186/s12883-017-0846-x. James SN, Wong A, Tillin T, Hardy R, Chaturvedi N, Richards M. Mid-life insulin resistance and type 2 diabetes on older age cognition: The explanatory role of early life advantage. PMID: 31359084 Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Parker TD, Malone IB, Lu K, James SN, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Gordon E, Coath W, Barnes A, Dickson J, Modat M, Thomas D, Crutch SJ, Hardy R, Richards M, Fox NC, Schott JM.Investigating the associations between blood pressure across adulthood and late-life brain structure and pathology in the 1946 British birth cohort: an epidemiological study. Lancet Neurol. 2019 Oct;18(10):942-952. PMID:31444142 PMCID:PMC6744368 Keuss SE, Parker TD, Lane CA, Hoskote C, Shah S, Cash DM, Keshavan A, Buchanan SM, Murray-Smith H, Wong A, James SN, Lu K, Collins J, Beasley DG, Malone IB, Thomas DL, Barnes A, Richards M, Fox N, Schott JM.Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort.BMJ Open. 2019 Jul 31;9(7):e029502. doi: 10.1136/bmjopen-2019-029502. Lu K, Nicholas JM, Collins J, James SN, Parker TD, Lane C, Keshavan A, Keuss SE, Buchanan S, Murray-Smith H, Cash DM, Sudre CH, Malone IB, Coath W, Wong A, Henley S, Crutch SJ, Fox NC, Richards M, Schott JM. Cognition at age 70: life course predictors and associations with brain pathologies. PMID: 31666352 Parker TD, Cash DM, Lane CAS, Lu K, Malone IB, Nicholas JM, James SN, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Sudre CH, Modat M, Thomas DL, Crutch SJ, Richards M, Fox NC, Schott JM.Hippocampal subfield volumes and pre-clinical Alzheimer's disease in 408 cognitively normal adults born in 1946PLoS One. 2019 Oct 17;14(10):e0224030. doi: 10.1371/journal.pone.0224030. eCollection 2019 PMID: 31622410 PMCID: PMC6797197 Parker T, Cash DM, Lane C, Lu K, Malone IB, Nicholas JM, James S, Keshavan A, Murray-Smith H, Wong A, Buchannan S, Keuss S, Sudre CH, Thomas D, Crutch S, Bamiou DE, Warren JD, Fox NC, Richards M, Schott JM.Pure tone audiometry and cerebral pathology in healthy older adults.J Neurol Neurosurg Psychiatry. 2020 Feb;91(2):172-176. doi: 10.1136/jnnp-2019-321897. Epub 2019 Nov 7.PMID: 31699832 Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Malone IB, Parker TD, Keshavan A, Buchanan SM, Keuss SE, James SN, Lu K, Murray-Smith H, Wong A, Gordon E, Coath W, Modat M, Thomas D, Richards M, Fox NC, Schott JM.Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.JAMA Neurol. 2019 Nov 4:1-9. doi: 10.1001/jamaneurol.2019.3774. [Epub ahead of print]PMID: 31682678 James AN, Lane CA, Parker TD, Lu K, Collins JD, Murray Smith H, Byford M, Wong A, Keshavan A, Buchanan S, Keuss SE, Kuh D, Fox NC, Schott JM, Richards Using a birth cohort to study brain health and preclinical dementia: Recruitment and participation rates in Insight 46. BMC Research Notes 2018;11:885 Wave 2 completed. 2020/21 papers Lane, C., T.D. Parker, D.M. Cash, K. Macpherson, E. Donnachie, et al. 2017. Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development. BMC Neurology. 17(1):75. DOI: 10.1186/s12883-017-0846-x. *Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Parker TD, Malone IB, Lu K, James SN, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Gordon E, Coath W, Barnes A, Dickson J, Modat M, Thomas D, Crutch SJ, Hardy R, Richards M, Fox NC, Schott JM. Investigating the associations between blood pressure across adulthood and late-life brain structure and pathology in the 1946 British birth cohort: an epidemiological study. Lancet Neurol. 2019 Oct;18(10):942-952. PMID:31444142 PMCID:PMC6744368 *Parker TD, Cash DM, Lane CA, Lu K, Malone IB, Nicholas JM, James SN, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Sudre CH, Thomas DL, Crutch SJ, Fox NC, Richards M, Schott JM.Amyloid ß influences the relationship between cortical thickness and vascular load. Alzheimers Dement (Amst). 2020 Apr 17;12(1):e12022. doi: 10.1002/dad2.12022. eCollection 2020. PMID: 32313829 [PubMed] Free PMC Article *Smith H, Cash DM, Sudre CH, Malone IB, Coath W, Wong A, Henley SMD, Fox NC, Richards M, Schott JM, Crutch SJ.Increased variability in reaction time is associated with amyloid beta pathology at age 70. Lu K, Nicholas JM, James SN, Lane CA, Parker TD, Keshavan A, Keuss SE, Buchanan SM, Murray- Alzheimers Dement (Amst). 2020 Aug 10;12(1):e12076. doi: 10.1002/dad2.12076. eCollection 2020. PMID: 32789161 Free PMC article. Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort. Lane CA, Barnes J, Nicholas JM, Sudre CH, Cash DM, Malone IB, Parker TD, Keshavan A, Buchanan SM, Keuss SE, James SN, Lu K, Murray-Smith H, Wong A, Gordon E, Coath W, Modat M, Thomas D, Richards M, Fox NC, Schott JM. JAMA Neurol. 2020 Feb 1;77(2):175-183. doi: 10.1001/jamaneurol.2019.3774. PMID: 31682678 Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70. Keshavan A, Pannee J, Karikari TK, Rodriguez JL, Ashton NJ, Nicholas JM, Cash DM, Coath W, Lane CA, Parker TD, Lu K, Buchanan SM, Keuss SE, James SN, Murray-Smith H, Wong A, Barnes A, Dickson JC, Heslegrave A, Portelius E, Richards M, Fox NC, Zetterberg H, Blennow K, Schott JM. Brain. 2021 Jan 22:awaa403. doi: 10.1093/brain/awaa403. Online ahead of print. PMID: 33479777 |
| Start Year | 2012 |
| Description | Institute of Mental Health UCL collaboration |
| Organisation | Institute of Mental Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data preparation, analysis, expertise advice, manuscipt preparation. |
| Collaborator Contribution | Data preparation, analysis, expertise advice, manuscipt preparation. |
| Impact | None to date |
| Start Year | 2019 |
| Description | KCL - PP |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | PhD Supervision |
| Collaborator Contribution | PhD Supervision |
| Impact | 2 PhD students recruited |
| Start Year | 2019 |
| Description | KX collaboration |
| Organisation | Leiden University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Provides cognitive expertise and NSHD data, advice on study design, data analysis and manuscript preparation |
| Collaborator Contribution | Data analysis and creation of manuscripts |
| Impact | Xu Parental bonding instrument PMID 27485970 Data set received |
| Start Year | 2016 |
| Description | Mental health and other psychological therapy Outcomes; their relationship to Dementia Incidence in the Following Years (MODIFY) |
| Organisation | University College London |
| Department | Division of Psychology & Language Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research about the topic of Mental health and other psychological therapy Outcomes - provide data and mental health expertise for analysis and manuscript preparation |
| Collaborator Contribution | Research about the topic of Mental health and other psychological therapy Outcomes - provide data and expertise for analysis and manuscript preparation |
| Impact | Successful grant application to Alzheimer's Society |
| Start Year | 2020 |
| Description | OOTLES (Out Of The Long Economic Shadows) |
| Organisation | London School of Economics and Political Science (University of London) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | ESRC STAI-funded collaboration to estimate £ costs of adolescent mental health problems. Mental health research expertise, analysis, advice on manuscripts |
| Collaborator Contribution | ESRC STAI-funded collaboration to estimate £ costs of adolescent mental health problems. Health economics expertise, analysis, advice on manuscripts |
| Impact | First draft paper currently in progress |
| Start Year | 2019 |
| Description | Oxford Brookes |
| Organisation | Oxford Brookes University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Data preparation, analysis, publication creation for one off paper |
| Collaborator Contribution | Data preparation, analysis, publication creation for one off paper |
| Impact | Upcoming paper |
| Start Year | 2020 |
| Description | Proteomics |
| Organisation | Stanford University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaborating in a proteomics project |
| Collaborator Contribution | Collaborating in a proteomics project |
| Impact | Some preliminary publications |
| Start Year | 2022 |
| Description | SABRE |
| Organisation | University College London |
| Department | Institute of Cardiovascular Science |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide cognition and mental health expertise. Advising on analysis and manuscript preparation. |
| Collaborator Contribution | Data analysis and manuscript preparation |
| Impact | Park C, Williams E, Chaturvedi N, Tillin T, Stewart R, Richards M, Shibata D, Mayet J, Hughes A. Associations between left ventricular dysfunction and brain structure and function: Findings from the SABRE study. PMID:28420646 PMC5533007 |
| Start Year | 2016 |
| Description | Stonybrook University Collaboration (SC) |
| Organisation | Stony Brook University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaboration on cognitive ageing in the NSHD Advising and collaborating on papers |
| Collaborator Contribution | Collaboration on cognitive ageing in the NSHD Analysing data, collaborating on papers |
| Impact | PMID: 26315501 Denier N 2017. Retirement and cognition: A life course view. PMID: 28781588. Clouston S 2017.Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. PMID: 27626057 Clouston S 2017. Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders. PMID: 29201993 Clouston SAP, Smith DM, Mukherjee S, Zhang Y, Hou W, Link BG, Richards M. Education and cognitive decline: An integrative analysis of global longitudinal studies of cognitive aging. J Gerontol B Psychol Sci Soc Sci. 2019 May 6. pii: gbz053. doi: 10.1093/geronb/gbz053. [Epub ahead of print] PMID: 31059564 Clouston S, Diminich E, Kotov R, Pietrzak R, Richards M, Spiro A, Deri Y, Carr M, Yang X, Gandy S, Sano M, Bromet E, Luft B. Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events of 9/11/2001. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2019, 11, 628-636 |
| Start Year | 2014 |
| Description | UK Dementia Platform |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | Swansea University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | UK Dementia Platform |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | LHA will provide epidemiological/cognitive ageing expertise to this project and also make available any willing/suitable NSHD participants. |
| Collaborator Contribution | The aim is to create an integrated research environment enabling better, quicker and more cost-effective dementia science; focussing on the molecular determinants of neurodegenration and their translation into therapeutic and public health interventions. The strategic objectives are, in partnership with industry, to deliver: 1. Data integration across cohorts for rapid evidence synthesis. 2. Single-point data access for cohorts studies. 3. Strategic re-purposing of cohorts for discovery and trials readiness. 4. More efficient methods for conducting experimental studies. 5. An experimental programme focussing on the early detection of decline and treatment of dementia. The work programme comprises 15 work packages, each contributing in some way to one or more of the platform's strategic objectives. The platform includes a growing number of networks (currently comprising imaging, informatics and stem cells) which coordinate activity within specialist disciplines and facilitate cross-cutting activity across the platform. |
| Impact | Grant awarded by MRC Regular steering committee meetings Interviews for WP1 Creation of a data portal http://portal.dementiasplatform.uk/account/dataportal data access and deposit documents created First wave of Neuroimaging is completed and the second wave is underway Bauermeister S plus 70 co-authors. Data Resource Profile: The Dementias Platform UK (DPUK) Data Portal. Biorxiv March 25th 2019: https://www.biorxiv.org/content/10.1101/582155v1 |
| Start Year | 2009 |
| Description | University of Aberdeen |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint working on a research paper - data provision, analysis, publication creation |
| Collaborator Contribution | Joint working on a research paper - data provision, analysis, publication creation |
| Impact | Upcoming paper |
| Start Year | 2020 |
| Description | 75th online birthday talk series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | A series of five talks were orgnaised for the birthday week in March to celbrate 75 years of the NSHD. The topics covered were recent finding, future plans, covid research and cross cohort work, the history of the NSHD and archive and how the childhood questionnaires are being used in current research. The talks were live streamed from youtube and we had on average 100 peopl ewatching and lots of questions were asked throughout each session. |
| Year(s) Of Engagement Activity | 2021 |
| Description | 78th study members newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | The annual Newsletter to the study members to update them on what has been happening over the last 12 months. This is linked to Aim 3 of the comms strategy to ensure that all LHA cohort study members feel valued and ensuring frequent and meaningful contact. |
| Year(s) Of Engagement Activity | 2024 |
| URL | http://nshd.mrc.ac.uk/78th-birthday/newsletter |
| Description | ARUK UCL network public engagement called "Meet the Scientist", 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Sarah James, Kirsty (Macpherson) Lu, Hannah Carr, and Maria Popham participated in an ARUK-UCL network public engagement event called "Meet the Scientist". The Insight 46 team members set up an information stall called "Insight 46: Scanning people in the longest-running British Birth Cohort". The stall included information about the MRC National Survey of Health and Development and about Insight 46, including examples of cognitive tests. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Alzheimer's Association International Conference (AAIC) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Present research at AAIC, which is the largest international meeting dedicated to advancing dementia science. The purpose is to disseminate our research and to learn about current and novel research in dementia science. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020,2021,2022,2023 |
| Description | Alzheimer's Association International Conference (AAIC) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Present research at AAIC, which is the largest international meeting dedicated to advancing dementia science. The purpose is to disseminate our research and to learn about current and novel research in dementia science. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019,2020 |
| Description | Alzheimer's research UK stall at New Scientist live |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | We had a stand at this event to promote the cognitive research the unit carries out funded by ARUK by providing information to the general public and letting them play educational games to learn more about it. People took leaflets and engaged with the scientists by asking questions. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Brown, Oral Presentation, Neuroscience Next, Online Symposium, 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Tom Brown, Oral Presentation, Neuroscience Next, Online Symposium, 2023. Talk entitled: Investigating relationships between changes in white matter hyperintensity volume and hippocampal atrophy in the 1946 British birth cohort (Insight46) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Brown, Poster at AAIC (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Tom Brown presented a poster at AAIC 2023 entitled: Associations of white matter hyperintensity change with classical Alzheimer's disease biomarkers and cardiovascular risk in the 1946 British birth cohort (Insight 46) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Buchanan, ABN Edinburgh (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah Buchanan submitted an abstract and was invited to present an oral presentation entitled, "Relationships between walking speed, cognition & brain pathologies - an imaging study of the 1946 birth cohort". |
| Year(s) Of Engagement Activity | 2019 |
| Description | Buchanan, International Congress of Parkinson's Disease and Movement Disorders France (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah Buchanan presented a poster at the 2019 International Congress of Parkinson's Disease and Movement Disorders in Nice, France. The poster was entitled, "The cognitive profile associated with mild parkinsonian signs in a British Birth Cohort at age 69-71." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cartlidge, Poster at AAIC (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Molly Cartlidge presented a poster at AAIC 2023 entitled: Exposure to area disadvantage across the life course and its influence on cognition and neurodegenerative pathology in later life. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Caterina, Oral Presentation at ARUK Early Careers Day 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Felici Caterina give an oral presentation at ARUK Early Career Day, London, Jan 2024. Talk entitled: Caterina F, Green RE, Warren-Gash C, Butt J, Waterboer T, Hughes AD, Schott JM, Keshavan A, Chaturvedi N, Richards M, Williams DM. Common infections and amyloid-ß pathology in vivo: a population-based study |
| Year(s) Of Engagement Activity | 2024 |
| Description | Chaired 4-nation Policy Roundtable on mental health |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Policy Roundtable with representatives from all 4 -nations and various different government departments in each nation. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Coath, Oral Presentation, Euro-PAD scientific symposium, 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Will Coath gave an Oral Presentation at Euro-PAD scientific symposium, 2023. Talk entitled: MK-6240 tau PET in an Aß-enriched sample from the 1946 British birth cohort - Insight 46 |
| Year(s) Of Engagement Activity | 2023 |
| Description | Coath, Oral Presentation, Neuroscience Next, Online Symposium, 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Will Coath, Oral Presentation, Neuroscience Next, Online Symposium, 2023. Talk entitled: Imaging amyloid-beta, tau and neurodegeneration in preclinical Alzheimer's disease |
| Year(s) Of Engagement Activity | 2023 |
| Description | Coath, Poster at AAIC (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Will Coath presented a poster at AAIC 2023 entitled: MK-6240 tau-PET in an Aß-enriched sample from the 1946 British birth cohort |
| Year(s) Of Engagement Activity | 2023 |
| Description | Coath, Poster at Human Amyloid Imaging Conference (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Will Coath presented a poster at 2023 Human Amyloid Imaging Conference entitled: [18F]MK-6240 tau-PET in an Aß-enriched sample from the 1946 British birth cohort - Insight 46. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Conference Presentation - Society for Longitudinal and Lifecourse Studies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of results from a fellowship project to an international audience. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Conference Presentation - Understanding Society Scientific Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation at The Universty of Essex as part of the Understanding Society Scientific Conference. |
| Year(s) Of Engagement Activity | 2023 |
| Description | DEMON BIOMARKERS WORKING GROUP TALK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | I presented together with two other researchers our study on the association of common infections and amyloid-beta deposition in the brain , at the DEMON network working group for biomarkers. This working group comprises researchers working on dementia and using biomarkers specifically in their research. The talk sparked several questions. |
| Year(s) Of Engagement Activity | 2023 |
| Description | EU Parliament panel for young people and mental health |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Online panel last week on Young People and Mental Health organised by the EU Parliament (and watched live by around 5000 people and then by another 2.5K since. Discussing young people's mental health and how the COVID-19 pandemic, lockdowns, long periods of isolation and insecurity have affected the situation. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Interviewee for ARUK policy report Brain Health |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Part of stakeholder interviewees for the new ARUK policy report Brain Health: A new way to think about dementia risk reduction, which they are launching today. This underpins a broader new public awareness campaign called Think Brain Health, which they are also launching today. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Its all academic 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA hosted a Science Fair at UCL with the MRC Laboratory for Medical Cell Biology and the MRC Prion. This was a free family fun day for all ages and included hands-on activities, interactive demonstrations, games and exhibitions. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing. |
| Year(s) Of Engagement Activity | 2019 |
| Description | James, AAIC Los Angeles (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah James was invited to give an oral presentation at AAIC 2019 in Los Angeles entitled, "Divergent associations between life course cognitive trajectories and brain pathologies: findings from the 1946 British birth cohort." |
| Year(s) Of Engagement Activity | 2019 |
| Description | James, ARUK Public Engagement Event (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Sarah James presented a poster at the 2019 ARUK Public Engagement Event that was entitled, "Insight 46: Scanning people in the longest-running British Birth Cohort." |
| Year(s) Of Engagement Activity | 2019 |
| Description | James, British Heart Foundation, 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah James was invited to give a presentation at the British Heart Foundation in October 2018. The presentation was entitled, "Investigating risk factors for dementia: Over 65 years of follow-up in the 1946 Birth Cohort." |
| Year(s) Of Engagement Activity | 2018 |
| Description | James, Poster at AAIC (2020) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah James submitted an abstract to and presented a poster during AAIC 2020, which was held as a virtual conference. The poster was entitled, "Lifetime cigarette smoking and later-life brain health: the population-based 1946 British Birth Cohort." |
| Year(s) Of Engagement Activity | 2020 |
| Description | James, Poster at AAIC (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Sarah James presented a poster at AAIC 2023 entitled: Timing of physical activity across sdulthood on later-life brain health: 30 years follow-up in 1946 British Birth Cohort. |
| Year(s) Of Engagement Activity | 2023 |
| Description | James, Poster at DPUK Conference (2018) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah James presented a poster at the 2018 DPUK conference entitled, "Life-course incidence of head Injury and subsequent later-life cognition." First prize award for best poster. |
| Year(s) Of Engagement Activity | 2018 |
| Description | James, UK Frontiers in Traumatic Brain Injury Conference, 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah James was invited to give a presentation at the UK Frontiers in Traumatic Brain Injury Conference in July 2018. The presentation was entitled, "Traumatic brain injury with loss of consciousness and subsequent cognitive trajectories." |
| Year(s) Of Engagement Activity | 2018 |
| Description | James, UK Sports Concussion Research Symposium, 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah James was invited to give a presentation to the UK Sports Concussion Research Symposium in November 2018. The presentation was entitled, "What have we learnt about longitudinal studies?". |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keir Starmer Visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Sir Keir Starmer, the Unit's local MP, met with staff, who explained the history of the NSHD and the most important findings. He learnt about Insight 46, Delphic and SABRE. He was particularly interested in understanding how people can age better, the extent of health inequalities across the country and what we can do to help shape future government policies. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keshavan, AAIC (2020) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Chris Lane was invited to give an oral presentation at AAIC 2020, which was held as a virtual conference. The presentation was entitled, "Plasma phosphor-tau in Insight 46 - associations with cerebral amyloid, structural imaging and cognition." |
| Year(s) Of Engagement Activity | 2020 |
| Description | Keshavan, AAIC Los Angeles (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Ashvini Keshavan was invited to give a presentation at AAIC 2019 in Los Angeles entitled, "Plasma tau and serum neurofilament light chain in Insight 46 - associations with cognition and brain imaging." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keshavan, ARUK Student Day (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Ashvini Keshavan gave a presentation at the 2019 ARUK Student Day that was entitled, "Blood biomarkers of amyloid, tau and neurofilament light chain in the 1946 British birth cohort - relationships with cerebral amyloid and brain imaging." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keshavan, Poster at AAIC (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ashvini Keshavan presented a poster at AAIC 2023 entitled: Plasma Alzheimer biomarkers in the 1946 British birth cohort: predicting conversion to amyloid PET positivity over a two-year follow up period. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Keshavan, Poster at AAIC (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Ashvini Keshavan presented a poster at AAIC 2023 entitled: Plasma Alzheimer biomarkers in the 1946 British birth cohort: predicting conversion to amyloid PET positivity over a two-year follow up period. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Keshavan, Poster at UCL Queen Square Symposium (2018) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Ashvini Keshavan presented a poster at the 2018 UCL Queen Square Symposium. The poster was entitled, "Exploring the role of blood-based biomarkers for Alzheimer's disease in a pre-clinical cohort: Insight 46 - The Neuroimaging Sub-study of the MRC National Survey of Health and Development" |
| Year(s) Of Engagement Activity | 2018 |
| Description | Keshavan, Presentation at AD/PD 2023: 17th International COnference on Alzheimer's & Parkinson's Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Ashvini Keshavan gave a talk entitled, "CSF tau and p-tau biomarkesr in the 1946 British birth cohort: associations with demographic factors, concordance with cerebral amyloid deposition." |
| Year(s) Of Engagement Activity | 2023 |
| Description | Keshavan, Presentation at annual BRAIN conference (2021) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Ashvini Keshavan was invited to give an oral presentation at the 2021 BRAIN conference. The presentation was entitled, "Population-based blood screening for pre-clinical Alzheimer's disease in a British birth cohort at age 70." |
| Year(s) Of Engagement Activity | 2016,2021 |
| Description | Keuss, AAN 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah Keuss submitted an abstract and was invited to make an oral presentation at AAN 2020. Her submission was entitled, "Incidental Findings on Brain Magnetic Resonance Imaging." |
| Year(s) Of Engagement Activity | 2020 |
| Description | Keuss, Interview for article in Medscape (2020) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Sarah Keuss was interviewed for an article in Medscape that was related to a publication (doi: 10.1136/bmjopen-2019-029502). The Medscape article was entitled, "Incidental finding on brain MRI seen in 5% of older patients". |
| Year(s) Of Engagement Activity | 2020 |
| Description | Keuss, Poster at AAIC (2020) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sarah Keuss submitted an abstract to and presented a poster during AAIC 2020, which was held as a virtual conference. The poster was entitled, "Cerebral amyloid and white matter hyperintensity volume are independently associated with rates of cerebral atrophy in Insight 46, a sub-study of the 1946 British birth cohort." |
| Year(s) Of Engagement Activity | 2020 |
| Description | LH&W and Convalescence Study conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The first face-to-face LH&W and Convalescence Study conference took place on November 17th/18th at The Danubius Hotel Regents Park. ~90 researchers from 15 institutions attended and made the event a great success. LHA researchers featured throughout the conference, including presentations from Professor Nish Chaturvedi, Dr Kishan Patel, Dr Khaled Rjoob and Dr Wels Jacques. Thank you to Dr Alisia Carnemolla , Dr Dylan Williams and Dr Chloe Park for organising the event. |
| Year(s) Of Engagement Activity | 2022 |
| Description | LHA Outputs |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Aim 1 of our Communiciations Strategy is to Create and maintain a unified and cohesive MRC Unit. The Monthly Newsletter aims to keep internal staff and students up to date with the Units activities and achievements. Feedback from users has been very positive and they feel it has imporoved internal communication across the Unit. |
| Year(s) Of Engagement Activity | 2021,2022,2023,2024 |
| Description | Lane, AAIC Chicago (2018) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Chris Lane submitted an abstract and gave a presentation at AAIC Chicago (2018) entitled, "Influences of blood pressure and blood pressure trajectories on cerebral pathology - results from a British birth cohort". This presentation sparked questions and discussion amongst attendees of the conference. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Lane, AAIC Los Angeles (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Chris Lane was invited to give an oral presentation at AAIC 2019 in Los Angeles. The presentation was entitled, "Early Adulthood Vascular Risk Strongly Predicts Brain Volumes and White Matter Disease, but Not Amyloid Status, at Age 69-71 Years - Evidence from a British Birth Cohort." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Lane, Parker, Murray-Smith, Poster at DPUK Symposium (2015) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Chris Lane, Dr Tom Parker, and Mrs Heidi Murray-Smith presented a poster at the 2015 DPUK Symposium. The poster was entitled, "A longitudinal amyloid-PET/MRI study of the MRC NSHD British 1946 birth cohort." |
| Year(s) Of Engagement Activity | 2015 |
| Description | Lane, Poster at DPUK Symposium (2016) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Chris Lane presented a poster on behalf of the Insight 46 study team at the 2016 DPUK Symposium. The poster was a summary of Work Package 4: Amyloid Discovery Cohort. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Lu, Poster at 2023 DPUK Annual Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Kirsty Lu presented a poster at 2023 DPUK Annual Meeting entitled: The Face-Name Associative Memory Exam (FNAME): sex differences and associations with brain atrophy and serum neurofilament light in older adults. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Lu, Poster at AAIC (2020) (1/2) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Kirsty Lu submitted an abstract to and presented a poster during AAIC 2020, which was held as a virtual conference. The poster was entitled, "Accelerated forgetting is sensitive to ß-amyloid pathology and cerebral atrophy in cognitively-normal 72-year-olds." |
| Year(s) Of Engagement Activity | 2020 |
| Description | Lu, Poster at AAIC (2020) (2/2) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Kirsty Lu submitted an abstract to and presented a poster during AAIC 2020, which was held as a virtual conference. The poster was entitled, "APOE-e4 carriers have superior recall on the "What was where?" visual short-term memory binding test at age 70, despite a detrimental effect of ß-amyloid. " |
| Year(s) Of Engagement Activity | 2020 |
| Description | Lu, Poster at AAIC (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Kirsty Lu presented a poster at AAIC 2023 entitled: Sex / gender bias on the Face-Name Associative Memory Exam in clinically-normal older adults |
| Year(s) Of Engagement Activity | 2023 |
| Description | Lu, Poster at APOE AAIC Advancements conference (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Kirsty Lu presented a poster at APOE AAIC Advancements conference (2023) entitled: Dissociable effects of APOE-e4 and amyloid status on memory performance between ages 70-72 in members of the British 1946 Birth Cohort. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Lu, Poster at ARUK annual conference (2018) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Kirsty Lu submitted an abstract and presented a poster at the 2018 ARUK annual conference. The poster was entitled, "What was where? Visual short-term memory binding in Insight 46." |
| Year(s) Of Engagement Activity | 2018 |
| Description | Lu, Poster at British Neuropsychological Society autumn meeting (2020) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Kisty Lu submitted an abstract to and presented a poster during the British Neuropsychological Society autumn meeting in 2020, which was held as a virtual conference. The poster was entitled, "Cognition at age 70 and its relationships with biomarkers of preclinical Alzheimer's disease." |
| Year(s) Of Engagement Activity | 2020 |
| Description | Lu, Poster at DPUK annual meeting (2017) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Kirsty Lu submitted an abstract and presented a poster at the DPUK annual meeting in 2017. The poster was entitled, "What was where? Visual short-term memory binding in the MRC 1946 Birth Cohort." |
| Year(s) Of Engagement Activity | 2017 |
| Description | Lu, Presentation at AAIC 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Kirsty Lu gave an oral presentation at AAIC 2023 entitled: Associations between accelerated long-term forgetting of Complex Figure Drawing, cerebral amyloid deposition, brain atrophy and serum neurofilament light in 72-year-olds. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Lu, Presentation at Monthly LHA Mental Ageing Meeting (2020) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Chris Lane was invited to give an oral presentation at the monthly LHA Mental Ageing meeting in March 2020. The presentation was related to her PhD and was related to the investigation of cognitive performance in Phase 1 of Insight 46. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Lu, Presention at Massachusetts General Hospital - Multicultural Alzheimer's Prevention Program: ApoE Symposium (2021) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Kirsty Lu was invited to give a presentation at Massachusetts General Hospital - Multicultural Alzheimer's Prevention Program: ApoE Symposium. The presentation was entitled, "Dissociable effects of APOE-e4 and ß-amyloid pathology on visual working memory. Winner of prize for best post-doc talk." |
| Year(s) Of Engagement Activity | 2021 |
| Description | MRC Festival June 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA hosted a Science Fair at UCL with the MRC Laboratory for Medical Cell Biology and the MRC Prion.This was a free family fun day for all ages andincluded hands-on activities, interactive demonstrations, games and exhibitions. LHA had their Game of Life activity which was an interactive game where participants learnt about our longitudinal research into healthy ageing. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Media Interest - covid 19 and mental health |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Press coverage of covid 19 and mental health - Telegraph, Independent, Mail, Sky News Radio, Talk Radio. Increased awareness of impact of covid 19 on young peoples' mental health. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Media interest - Dieting and weight worries on rise in teens. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media interest - Dieting and weight worries on rise in teens. Significantly higher numbers of Generation Z boys and girls in the UK are dieting to lose weight, and are likely to overestimate their own weight. Lots of press interest. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Media interest - Mental health of young people |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Media Interest - The Times, The Week, The Telegraph, Daily Mail. Increased awareness of mental health research and attempted suicide rates in young people |
| Year(s) Of Engagement Activity | 2021 |
| Description | Media interest in excerise and brain function paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Media interest on a paper around Exercising at least once a month linked to better brain function in later life Read: Guardian, More: Mail Online, CNN, Times (£), Irish Times, Mirror (2), Med Page Today, Independent, Evening Standard, Express, Telegraph (£), i News, U.S. News,Yahoo! News, CBS News, UCL News |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ucl.ac.uk/news/headlines/2023/feb/exercising-least-once-month-linked-better-brain-functi... |
| Description | Media interest in paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The paper "Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study" got picked up for a number of online news media |
| Year(s) Of Engagement Activity | 2022 |
| Description | Menopause age, type may be linked to cognitive performance |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | News article from Needham L, et al. Menopause and later-life cognition: Findings from the longest-running population-based birth cohort. Presented at: Alzheimer's Association International Conference; July 26-30, 2021 (virtual meeting). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.healio.com/news/primary-care/20210802/menopause-age-type-may-be-linked-to-cognitive-perf... |
| Description | NSHD 76th Birthday Pack |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | We sent a birthday card and newsletter to the NSHD study members |
| Year(s) Of Engagement Activity | 2022 |
| Description | NSHD Advisory Panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | We have 2 NSHD Advisory Panels. A discussion group with 12 study members and a email/postal group with 24 study members. We aim to hold 2 meetings of the discussion group per year. We send out information to the email/postal group as and when we have questions we would like to ask the study members. |
| Year(s) Of Engagement Activity | 2022,2023,2024 |
| Description | NSHD Roadshow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | This is a thank you to the study members and to satisfy aim 3 of the comms strategy to ensure that all LHA cohort study members feel valued and ensuring frequent and meaningful contact. It is also an opportunity to showcase the data collection opportunities avaliable to the study members for the Garmin watches and Insight 46 clinic visits. The recuritment so far has been lower than expected and so the events were organised to boost recruitment. |
| Year(s) Of Engagement Activity | 2024 |
| Description | NSHD Study Members Birthday Pack |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Every year for the study member's birthday we send them out a birthday card and newsletter |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nshd.mrc.ac.uk/newsletter-2023/ |
| Description | Needham, Poster at Organisation for the Study of Sex Differences (OSSD) conference (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Louisa Needham presented a poster at Organisation for the Study of Sex Differences (OSSD) conference (2023) entitled: Examining age at natural menopause in relation to cortical thickness at age 70 |
| Year(s) Of Engagement Activity | 2023 |
| Description | New Scientist Live |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We had a stall at New Scientist Live, which ran from 7th -9th October 2023. The first 2 days was the general public and the last day was for schools. In total there were 23,045 attendees. The intended purpose was to insipre the next generation of scientist and to educate around the importance of healthy ageing. It was also the perfect opportunity to train new researchers in public engagement events. We talked with a number of attendees who had never heard of longitudinal studies before. The balance test made attendees aware of how good / bad they were and some of the attendeess who purformed poorly mentioned they would do more exercise. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://live.newscientist.com/ |
| Description | Newspaper coverage of academic pressure systematic review |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Online and print exclusive with London Evening Standard on the paper: "The association between academic pressure and adolescent mental health problems: A systematic review" |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.standard.co.uk/news/health/exam-stress-teenagers-children-mental-health-risk-ucl-researc... |
| Description | Online presentation to cohort for NSHD 75th birthday celebration |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Engagement activity to present current and future research as part of the NSHD cohort 75th birthday celebration |
| Year(s) Of Engagement Activity | 2021 |
| Description | Oral presentation at International Psychogeriatric Association conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Disseminated findings to other researchers, practitioners and patient groups. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Parker, AAIC Los Angeles (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Thomas Parker was invited to give an oral presentation at AAIC 2019 in Los Angeles. The presentation was entitled, "Age, ß-amyloid and cognition selectively influence individual hippocampal subfield volumes: a study of 408 healthy adults born in 1946." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Parker, Poster at AAIC (2020) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Tom Parker submitted an abstract to and presented a poster during AAIC 2020, which was held as a virtual conference. The poster was entitled, "Cerebral amyloid deposition predicts cortical neuritic microstructure, but not cortical thickness, in cognitively healthy adults aged approximately 70 years old." |
| Year(s) Of Engagement Activity | 2020 |
| Description | Patient and Public Involvement panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | We held a patient and public involvement panel at UCL (02/2022) involving three former carers for people with dementia. The group provided feedback on the topic of social health and the aims of the JPND/Alzheimer's Society funded project "Social Health and Reserve in the Dementia Patient Journey (SHARED)", the relevance and meaning of our findings, our initial plans for the study on the role of depressive symptoms and inflammation as possible mediators, and ideas for translating results into practice. The contributions of the group helped to shape our aims for the mediation study and fed into the conceptual framework created by the wider SHARED network. In particular, during the panel, the group highlighted the importance of focusing on social health at different stages of dementia, including in the preclinical period, where the effects on social health may differ. The group also emphasised the effects of the Covid-19 pandemic on social health, which we examined in one of the studies described above. The possibility of direct impacts of social health on the brain were highlighted, as examined in our studies focused on brain reserve pathways. Similarly, mental health was highlighted as a potentially important factor, which we investigated as a mediator in several of our studies. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster presentation at AAIC conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Disseminated findings to other researchers, practitioners and patient groups. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation to clinical staff |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on academic pressure and adolescent mental health to child and adolescent psychiatrists |
| Year(s) Of Engagement Activity | 2024 |
| Description | Press Release - role of cognitive reserve markers from NSHD |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Paper picked up for a press release programme |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press coverage following a paper published in The Lancet re blood pressure and cognition |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | There was extensive press coverage following a paper published in The Lancet - Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study. The story was covered in most UK national papers and also on websites around the world. |
| Year(s) Of Engagement Activity | 2019 |
| Description | STEM ambassador: Science talk to A-level students. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Pupils attended a talk at a local high school to promote science as a career as part of the researchers STEM ambassador role. The talk sparked questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2019 |
| Description | School talk about the brain (LN) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | STEM talk for school Focused the talk on explaining some basics about the brain and cognition, and how we can use cohorts like NSHD to learn what factors throughout our lives might help us to have healthier brains when we are older. About 300 kids on the call and they asked lots of really great questions at the end such as • Can you survive if part of your brain is missing? • What's the main way that a child's brain is different to an adult's brain? • What things keep your brain healthy/are good for you brain? • How and when did you become interested in science? |
| Year(s) Of Engagement Activity | 2020 |
| Description | Schott and Keshavan, AAIC Los Angeles (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Jonathan Schott and Dr Ashvini Keshavan were invited to present a featured research session at AAIC 2019 in Los Angeles on the following topic: "The 1946 birth cohort - relationships between cerebral amyloid pathology using two independent methods for plasma amyloid beta measurement." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Schott and Richards, Article in The Conversation, November 2022 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Richards M and Schott JM. We've been studying the same people for 76 years - this is what we've found out about Alzheimer's disease. The Conversation. https://theconversation.com/weve-been-studying-the-same-people-for-76-years-this-is-what-weve-found-out-about-alzheimers-disease-183949 |
| Year(s) Of Engagement Activity | 2022 |
| Description | Schott, AAIC Amsterdam (2020) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Jonathan Schott submitted "Vascular risk factors and amyloid pathology: additive or interactive associations" as a featured research session at AAIC 2020 in Amsterdam. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Schott, AAIC Los Angeles (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Jonathan Schott gave a presentation at AAIC 2019 in Los Angeles entitled, "Two Independent Methods for Plasma Amyloid Beta Measurement." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Schott, ANZAN Annual Meeting Sydney (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Jonathan Schott was invited to present at the ANZAN Annual Meeting 2019 in Sydney. During the meeting, he presented on the ageing brain, clinical recognition of cognitive syndromes, and diagnostic markers for Alzheimer's disease. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Schott, ARUK blog, Oct 2022 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | ARUK blog: How a 76-year-long study has allowed a better understanding of brain health and dementia risk - Alzheimer's Research UK (alzheimersresearchuk.org) |
| Year(s) Of Engagement Activity | 2022 |
| Description | Schott, British Neuroscience Association Dublin (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Jonathan Schott was invited to present at the British Neuroscience Association in Dublin in 2019. The presentation was entitled, "Detecting preclinical dementia". |
| Year(s) Of Engagement Activity | 2019 |
| Description | Schott, Dementia London (2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Jonathan Schott was invited to present at the Dementia meeting in 2019 in London. The presentation was entitled, "Use of CSF biomarkers for dementia diagnosis." |
| Year(s) Of Engagement Activity | 2019 |
| Description | Schott, Dementia Masterclass (2019) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Jonathan Schott was invited to present a Dementia Masterclass at the Danish Dementia Research Centre in Copenhagen. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Museum Lates 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | LHA took their Life Course Golf Course activity to the Science Museum Lates. Participants were taken round the miniature golf course by our researchers (the caddy) and learnt about our longitudinal research into healthy ageing |
| Year(s) Of Engagement Activity | 2019 |
| Description | Stand at UCL Alzheimer's Research UK public engagement festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | We had a stand at this event to promote the cognitive research the unit carries out by providing information to the general public and letting them play educational games to learn more about it. People took leaflets and engaged with the scientists by asking questions. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Storey, Oral Presentation at AAIC (2020) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Matt Storey submitted an abstract to and was offered an oral presentation during AAIC 2020, which was held as a virtual conference. The poster was entitled, "Mid-life blood pressure and microstructural white matter: Findings from the 1946 British birth cohort." |
| Year(s) Of Engagement Activity | 2020 |
| Description | Street, Poster at AAIC (2020) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Rebecca Street submitted an abstract to and presented a poster during AAIC 2020, which was held as a virtual conference. The poster was entitled, "Performance on the Graded Naming Test in a population-based sample of 72-year-olds: associations with life-course predictors and ß-amyloid pathology." |
| Year(s) Of Engagement Activity | 2020 |
| Description | Street, Poster at ARUK London Network Centre Science Day (2023) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Rebecca Street presented a poster at ARUK London Network Centre Science Day (2023) entitled: Online 46: Usability and acceptability of remote online cognitive assessments in a longitudinal aging cohort. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Sudre, Abstract at ISMRM 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Carole Sudre submitted an abstract to and participated in the annual conference for ISMRM 2020, which was held as a virtual conference. The abstract was entitled, "Along-tract correlation analysis of diffusion metrics and white matter lesions in a 70-year old birth cohort." |
| Year(s) Of Engagement Activity | 2020 |
| Description | The Window |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | The Window is an immersive audio experience blending story, music and spatial sound. Love and grief; memory and science. In the darkness, you find yourself at the heart of a story about the things families don't talk about. Spanning three generations and 40 years, it asks what we inherit from the past and what control we have over the future. The Window is the recipient of one of Alzheimer's Research UK's inaugural Inspire Awards and a collaboration with Dr Sarah-Naomi James from the MRC Unit for Lifelong Health and Ageing at UCL. The development of The Window was supported by ARC, Stockton. Review of the experience by a critic here: https://noproscenium.com/a-view-into-the-verboten-with-the-window-review-c57a1ef5247d |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://fastfamiliar.com/artwork/the-window/ |
| Description | Wagen, Poster at AAIC (2020) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Aaron Wagen submitted an abstract to and presented a poster during AAIC 2020, which was held as a virtual conference. The poster was entitled, "Serum neurofilament light and cognitive assessment associate with machine-learning derived brain-predicted age in the British 1946 Birth cohort." |
| Year(s) Of Engagement Activity | 2020 |
| Description | What Works Centre for Wellbeing celebration reception |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | It was the celebration of five years of the What Works Centre for Wellbeing which they hosted a reception for at a Whitehall venue with stakeholders, peers, policy makers etc and one of the things they did at this event was announce the new projects that ESRC funded on which they are collaborators and mine was one of them, so had to give a brief presentation of what our project is about and then 'network' for a couple hours after as many interested people asked questions. |
| Year(s) Of Engagement Activity | 2020 |
| Description | head injury @ sky news |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://news.sky.com/story/suffering-a-head-injury-before-your-50s-can-lead-to-brain-issues-in-later-life-new-study-suggests-12243286 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://news.sky.com/story/suffering-a-head-injury-before-your-50s-can-lead-to-brain-issues-in-later... |
| Description | head injury @daily mail |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://www.dailymail.co.uk/health/article-9685849/What-experts-stave-dementia.html |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dailymail.co.uk/health/article-9685849/What-experts-stave-dementia.html |
| Description | head injury @ ARUK |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | https://www.alzheimersresearchuk.org/head-injuries-worsen-memory-and-thinking-decades-later/ |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.alzheimersresearchuk.org/head-injuries-worsen-memory-and-thinking-decades-later/ |