Lifecourse Determinants of Bone and Joint Disease
Lead Research Organisation:
University of Southampton
Department Name: UNLISTED
Abstract
The mission of the MRC Lifecourse Epidemiology Unit is to provide a centre of excellence which uses epidemiological methods to promote human health by delineating the environmental and occupational causes throughout the lifecourse of: (1) chronic musculoskeletal disorders (osteoporosis, osteoarthritis and sarcopenia); and (2) metabolic disorders (diabetes mellitus, obesity and cardiovascular disease). Through understanding these causes, we aim to develop population-based and high risk preventive strategies against these disorders. This programme will explore the origins of osteoporosis and its related fractures in the elderly, as well as osteoarthritis. These are the two commonest bone and joint disorders worldwide.
Technical Summary
Objectives: To (a) understand better the mechanisms which underlie the developmental origins of osteoporosis and other musculoskeletal disorders; and (b) develop intervention studies aimed at modifying later disease risk through nutritional and other interventions targeted at critical periods of development. Research proposals: The programme will address the developmental origins of osteoporotic fracture from molecule to population, using observational as well as interventional studies. Follow-up of participants in the Hertfordshire and Helsinki cohort studies will determine the growth trajectories of individuals at later risk of fracture, and explore the impact of these trajectories on bone size, geometry, mineral content, and volumetric density; the genetic contribution to these aspects of fracture risk will be studied through genome-wide screening as part of large international consortia. Further follow-up of children included in the Southampton Womens Survey will elucidate the parental influences on skeletal development during peri-conception, pregnancy and early postnatal life. Follow-up of these children through ages 6 and 8 years will extend our understanding of the relationship between maternal 25-hydroxyvitamin D status during pregnancy and childhood skeletal size, geometry and volumetric density. Our studies will permit exploration of interactions between prenatal and postnatal environmental influences such as physical activity (assessed using accelerometry), and diet (using questionnaires and biomarkers). Epigenetic mechanisms underlying the observed relationships between early environment and later bone health will be explored using samples of umbilical cord and placenta obtained from deliveries within SWS; DNA methylation status of key genes engaged in calcium transport, and maternal stress, will be related to childhood bone mass. A centrepiece of the programme will be the first randomised controlled trial to investigate whether supplementation of vitamin D during pregnancy serves to optimise skeletal development in the offspring (MAVIDOS). This aetiological trial will encompass sub-studies addressing intermediary outcome measures and the impact of vitamin D supplementation on other systems (body composition, immune function and respiratory development). Interventions to prevent osteoporotic fracture later in the lifecourse will be evaluated as part of the programme. Thus, in the MRC SCOOP trial, we test a novel methodology for risk stratification developed by the WHO in a large (n=11,500), pragmatic, randomised controlled trial. Finally, linkage with the NIHR Biomedical Research Unit in Musculoskeletal Science, University of Oxford, will permit development of a research theme addressing the lifecourse epidemiology of osteoarthritis; we shall study determinants of initiation and progression of this disorder, risk factors for arthroplasty failure, and the role of vitamin D in retarding the progression of OA. Impact: Musculoskeletal disorders have enormous health and economic impacts on society. Our research programme will permit the development of novel public health strategies to improve skeletal health throughout the lifecourse, and reduce osteoporotic fractures in future generations. Greater understanding of the epidemiology of osteoarthritis (the commonest joint disorder worldwide) will contribute to parallel strategies that reduce the incidence and morbidity associated with this disorder.
Organisations
- University of Southampton (Lead Research Organisation)
- World Health Organization (WHO) (Collaboration)
- University of Manchester (Collaboration)
- University College London (Collaboration)
- McGill University (Collaboration)
- National Institute of Health and Medical Research (INSERM) (Collaboration)
- University College Dublin (Collaboration)
- University of Gothenburg (Collaboration)
- University of Southern Denmark (Collaboration)
- University of South Carolina (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- QUEEN MARY UNIVERSITY OF LONDON (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- UNIVERSITY OF ABERDEEN (Collaboration)
- University of Sheffield (Collaboration)
- University College Cork (Collaboration)
- Free University of Amsterdam (Collaboration)
- University of Helsinki (Collaboration)
- University of Amsterdam (Collaboration)
- Erasmus University Rotterdam (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- Autonomous University of Barcelona (UAB) (Collaboration)
- University of Bristol (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
Publications
Moon R
(2024)
Feldman and Pike' s Vitamin D
Skjødt MK
(2024)
Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration
(2024)
Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses.
in The lancet. Diabetes & endocrinology
Burton MA
(2024)
The serum small non-coding RNA (SncRNA) landscape as a molecular biomarker of age associated muscle dysregulation and insulin resistance in older adults.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Related Projects
Project Reference | Relationship | Related To | Start | End | Award Value |
---|---|---|---|---|---|
MC_UU_12011/1 | 01/05/2013 | 30/06/2021 | £4,112,000 | ||
MC_UU_12011/2 | Transfer | MC_UU_12011/1 | 01/05/2013 | 30/06/2021 | £2,705,000 |
MC_UU_12011/3 | Transfer | MC_UU_12011/2 | 01/05/2013 | 30/06/2021 | £2,101,000 |
MC_UU_12011/4 | Transfer | MC_UU_12011/3 | 01/05/2013 | 30/06/2021 | £4,051,000 |
MC_UU_12011/5 | Transfer | MC_UU_12011/4 | 01/05/2013 | 30/06/2021 | £1,986,000 |
Title | DXA video UK Biobank |
Description | DXA video UK Biobank |
Type Of Art | Film/Video/Animation |
Year Produced | 2014 |
Impact | DXA video UK Biobank |
Title | IOF Webinar (NCH,CC) |
Description | IOF CTF webinars |
Type Of Art | Film/Video/Animation |
Year Produced | 2020 |
Impact | IOF CTF webinars |
Title | International Osteoporosis Foundation Video |
Description | International Osteoporosis Foundation Video |
Type Of Art | Film/Video/Animation |
Year Produced | 2014 |
Impact | International Osteoporosis Foundation Video |
Title | LifeLab |
Description | Picture |
Type Of Art | Image |
Year Produced | 2014 |
Impact | LifeLab |
Title | National Osteoporosis Society Video |
Description | National Osteoporosis Society Video |
Type Of Art | Film/Video/Animation |
Year Produced | 2014 |
Impact | National Osteoporosis Society Video |
Title | Osteoarthritis webinar |
Description | Osteoarthritis webinar |
Type Of Art | Film/Video/Animation |
Year Produced | 2014 |
Impact | Osteoarthritis webinar |
Title | ROS Osteoporosis Research Roadmap video |
Description | ROS Osteoporosis Research Roadmap video |
Type Of Art | Film/Video/Animation |
Year Produced | 2020 |
Impact | Increased awareness of osteoporosis |
Description | Contribution to SACN vitamin D guidance |
Geographic Reach | National |
Policy Influence Type | Citation in other policy documents |
Description | European guidance on very high fracture risk (NCH, CC) |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | Global Alliance for Musculoskeletal Disease |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
Impact | Global Alliance for Musculoskeletal Disease |
Guideline Title | IOF guidelines for the management of ONJ |
Description | IOF guidance on ONJ |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in clinical guidelines |
Impact | IOF guidelines on ONJ |
Description | Map of Medicine OP and Vitamin D |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Improved and more efficient treatment of osteoporosis and vitamin D deficiency |
Description | National Osteoporosis Guideline Group Advisory Committee (NCH, CC) |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | RCOG guidance on Vitamin D in pregnancy |
Geographic Reach | National |
Policy Influence Type | Citation in clinical reviews |
Description | EPOSA |
Amount | £225,057 (GBP) |
Organisation | Porticus |
Sector | Charity/Non Profit |
Country | Global |
Start | 12/2013 |
End | 11/2016 |
Description | NIHR Senior Investigator Award |
Amount | £75,000 (GBP) |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 10/2014 |
End | 09/2017 |
Description | NOS Project Grant CPRD |
Amount | £79,905 (GBP) |
Organisation | Royal Osteoporosis Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2014 |
End | 12/2016 |
Description | Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture |
Amount | £36,000 (GBP) |
Organisation | University of Southampton |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2022 |
End | 09/2025 |
Description | Preventing broken bones in older people: from research to policy to practice |
Amount | £29,566 (GBP) |
Funding ID | MRF-145-0011-DG-HARV-C0913 |
Organisation | Medical Research Council (MRC) |
Department | Medical Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 09/2022 |
Description | UK Biobank Imaging |
Amount | £9,600,000 (GBP) |
Funding ID | MC_PC_12027 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2014 |
End | 12/2015 |
Description | UK Centre of Excellence for Musculoskeletal Health and Work |
Amount | £1,400,000 (GBP) |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 12/2014 |
End | 11/2019 |
Description | UKRI WCL Capital funding 2020 2021 DXA and MSK Scanning Suite |
Amount | £216,857 (GBP) |
Funding ID | 4050801857 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 10/2020 |
End | 03/2021 |
Title | Batman |
Description | Bayesian analysis of epigenome-wide methylation |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | Bayesian analysis of epigenome-wide methylation |
Title | Hertfordshire Cohort Study |
Description | Range of phenotypic data, DNA and posterity blood samples. |
Type Of Material | Biological samples |
Year Produced | 2006 |
Provided To Others? | Yes |
Impact | Numerous publications (see list for details). |
Title | High resolution peripheral quantitative computed tomography |
Description | Obtains virtual bone biopsy |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | Obtains virtual bone biopsy |
Title | Hipmorph |
Description | Automated assessment of hip OA |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | Automated assessment of hip OA |
Title | Novel seasonal adjustment for vitamin D concentrations |
Description | Novel method for adjusting the vitamin D concentrations for season, independent of assays used. |
Type Of Material | Model of mechanisms or symptoms - human |
Provided To Others? | No |
Impact | Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation. Moon RJ, Crozier SR, Dennison EM, Davies JH, Robinson SM, Inskip HM, Godfrey KM, Cooper C, Harvey NC. Am J Clin Nutr. 2015 Nov;102(5):1081-7. doi: 10.3945/ajcn.115.115295. |
Title | Complex multi source datasets |
Description | Complex multi source datasets |
Type Of Material | Data analysis technique |
Provided To Others? | No |
Impact | Complex multi source datasets |
Title | Epigenetic microarray data distribution |
Description | Epigenetic microarray data distribution |
Type Of Material | Data analysis technique |
Provided To Others? | No |
Impact | Epigenetic microarray data distribution |
Title | EuroHealth Ageing |
Description | EuroHealth Ageing |
Type Of Material | Database/Collection of data |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | Mechanisms of ageing |
Title | Growth modelling |
Description | Growth modelling |
Type Of Material | Data analysis technique |
Provided To Others? | No |
Impact | Growth modelling |
Title | Hierarchical Data Modelling |
Description | Hierarchical Data Modelling |
Type Of Material | Data analysis technique |
Provided To Others? | No |
Impact | Hierarchical Data Modelling |
Description | ALPHABET |
Organisation | Erasmus University Rotterdam |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | National Institute of Health and Medical Research (INSERM) |
Department | Center for Epidemiological and Bio Statistics Research at Sorbonne |
Country | France |
Sector | Public |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | University College Dublin |
Department | School of Physics |
Country | Ireland |
Sector | Academic/University |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | University College Dublin |
Country | Ireland |
Sector | Academic/University |
PI Contribution | WP5, bone outcomes |
Collaborator Contribution | Consortium |
Impact | Ongoing |
Start Year | 2017 |
Description | ALPHABET |
Organisation | University of Bristol |
Department | Biomedical Research Unit in Nutrition, Diet and Lifestyle |
Country | United Kingdom |
Sector | Hospitals |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALPHABET |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | WP5, bone outcomes |
Collaborator Contribution | Consortium |
Impact | Ongoing |
Start Year | 2017 |
Description | ALPHABET |
Organisation | University of South Carolina |
Department | Arnold School of Public Health |
Country | United States |
Sector | Academic/University |
PI Contribution | Epigenetic determinants of bone development |
Collaborator Contribution | Epigenetic determinants of body composition and cognition |
Impact | N/A |
Start Year | 2016 |
Description | ALSPAC placenta |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Placental determinants of bone mass |
Collaborator Contribution | Placental determinants of bone mass |
Impact | Ongoing |
Start Year | 2013 |
Description | ARUK/MRC Centre of Excellence in Work and Musculoskeletal Health |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research collaboration |
Collaborator Contribution | Research collaboration |
Impact | PhD students |
Start Year | 2015 |
Description | ARUK/MRC Centre of Excellence in Work and Musculoskeletal Health |
Organisation | University of Oxford |
Department | School of Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research collaboration |
Collaborator Contribution | Research collaboration |
Impact | PhD students |
Start Year | 2015 |
Description | AUGMENT UK Biobank collaboration |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | AUGMENT UK Biobank collaboration |
Collaborator Contribution | AUGMENT UK Biobank collaboration |
Impact | AUGMENT UK Biobank collaboration |
Start Year | 2017 |
Description | AUGMENT UK Biobank collaboration |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | AUGMENT UK Biobank collaboration |
Collaborator Contribution | AUGMENT UK Biobank collaboration |
Impact | AUGMENT UK Biobank collaboration |
Start Year | 2017 |
Description | CPRD |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | UK Osteoporosis Epidemiology |
Collaborator Contribution | UK Osteoporosis Epidemiology |
Impact | UK Osteoporosis Epidemiology |
Start Year | 2014 |
Description | Danish Population Registry |
Organisation | University of Southern Denmark |
Country | Denmark |
Sector | Academic/University |
PI Contribution | Scientific collaboration |
Collaborator Contribution | Scientific collaboration |
Impact | 2 papers |
Start Year | 2013 |
Description | Danish Population Registry |
Organisation | University of Southern Denmark |
Country | Denmark |
Sector | Academic/University |
PI Contribution | Scientific collaboration |
Collaborator Contribution | Scientific collaboration |
Impact | 2 papers |
Start Year | 2013 |
Description | Dr Ann Prentice |
Organisation | Medical Research Council (MRC) |
Department | MRC Human Nutrition Research Group |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research Collaboration |
Collaborator Contribution | Research Collaboration |
Impact | Clinical Impact |
Start Year | 2009 |
Description | Dr Brent Richards |
Organisation | McGill University |
Country | Canada |
Sector | Academic/University |
PI Contribution | Research Collaboration |
Collaborator Contribution | Research Collaboration |
Impact | Clinical Impact |
Start Year | 2008 |
Description | Dr Ken Ong |
Organisation | University of Cambridge |
Department | MRC Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research Collaboration |
Collaborator Contribution | Research Collaboration |
Impact | Clinical impact |
Start Year | 2008 |
Description | Dr Rebecca Hardy |
Organisation | University College London |
Department | MRC Unit for Lifelong Health and Ageing |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research Collaboration |
Collaborator Contribution | Research Collaboration |
Impact | Clinical Impact |
Start Year | 2006 |
Description | EPOSA |
Organisation | Free University of Amsterdam |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Collaborative science. |
Collaborator Contribution | Collaborative science. |
Impact | 5 papers |
Start Year | 2013 |
Description | Fracture Risk Assessment |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Fracture Risk Assessment |
Collaborator Contribution | Fracture Risk Assessment |
Impact | Fracture Risk Assessment |
Start Year | 2014 |
Description | Genetic Epidemiology of type 2 diabetes mellitus |
Organisation | University of Cambridge |
Department | Department of Clinical Biochemistry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contribution of anonymised phenotypic data; statistical expertise |
Impact | Publication. PubMed ID: 17019603 |
Start Year | 2006 |
Description | HR pQCT |
Organisation | University of Southampton |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Inflammatory disease, bone erosion |
Collaborator Contribution | Inflammatory disease, bone erosion |
Impact | Inflammatory disease, bone erosion |
Start Year | 2014 |
Description | IOF Barcelona |
Organisation | Autonomous University of Barcelona (UAB) |
Country | Spain |
Sector | Academic/University |
PI Contribution | Scientific collaboration |
Collaborator Contribution | Scientific collaboration |
Impact | 3 papers |
Start Year | 2014 |
Description | Lung function in 6 year old children |
Organisation | University of Southampton |
Department | School of Medicine Southampton |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Data collection, grant and paper writing |
Collaborator Contribution | Grant and paper writing. Data collection, analysis of samples |
Impact | Papers now submitted |
Start Year | 2007 |
Description | MAVIDOS Childhood Follow up |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Recruitment to MAVIDOS 6 year follow-up in Sheffield |
Collaborator Contribution | Recruitment to MAVIDOS six-year follow-up in Sheffield |
Impact | N/A |
Start Year | 2016 |
Description | MAVIDOS Childhood Follow-up Oxford |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Recruitment of children to MAVIDOS six-year follow-up in Oxford |
Collaborator Contribution | Recruitment of children to MAVIDOS six-year follow-up in Oxford |
Impact | N/A |
Start Year | 2016 |
Description | MAVIDOS Oxford CVD |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Vitamin D in pregnancy and offspring cardiac structure and function |
Collaborator Contribution | Vitamin D in pregnancy and offspring cardiac structure and function |
Impact | Ongoing |
Start Year | 2015 |
Description | Nutrition BRU |
Organisation | University of Southampton |
Department | Faculty of Health Sciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Preparation of application, administration and conduct of some of the core projects |
Collaborator Contribution | Allowed us to conduct complementary studies arising out of the Southampton Women's Survey |
Impact | Grant funding |
Start Year | 2008 |
Description | ODIN |
Organisation | University College Cork |
Country | Ireland |
Sector | Academic/University |
PI Contribution | Scientific collaboration |
Collaborator Contribution | Scientific collaboration |
Impact | 3 papers |
Start Year | 2013 |
Description | Prof Diana Kuh |
Organisation | University College London |
Department | MRC Unit for Lifelong Health and Ageing |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research Collaboration |
Collaborator Contribution | Research Collaboration |
Impact | Clinical Impact |
Start Year | 2009 |
Description | Prof Paul Lips |
Organisation | University of Amsterdam |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Research Collaboration |
Collaborator Contribution | Research Collaboration |
Impact | Clinical Impact |
Start Year | 2007 |
Description | SARCOFRAX |
Organisation | University of Gothenburg |
Country | Sweden |
Sector | Academic/University |
PI Contribution | Developing sarcopenia outcome risk calculator |
Collaborator Contribution | Developing sarcopenia outcome risk calculator |
Impact | ongoing |
Start Year | 2020 |
Description | SARCOFRAX |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developing sarcopenia outcome risk calculator |
Collaborator Contribution | Developing sarcopenia outcome risk calculator |
Impact | ongoing |
Start Year | 2020 |
Description | Shape Modelling |
Organisation | University of Aberdeen |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Hip and knee shape modelling for osteoarthritis |
Collaborator Contribution | Hip and knee shape modelling for osteoarthritis |
Impact | Hip and knee shape modelling for osteoarthritis |
Start Year | 2014 |
Description | UK Biobank |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | DXA Lead |
Collaborator Contribution | Other imaging |
Impact | 1 paper |
Start Year | 2014 |
Description | UK Biobank Bristol |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Determinants of bone mass and fracture risk |
Collaborator Contribution | Determinants of bone mass and fracture risk |
Impact | Ongoing |
Start Year | 2016 |
Description | UK Biobank Sheffield |
Organisation | University of Sheffield |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | DXA pixel mapping- epidemiology and UKB |
Collaborator Contribution | DXA pixel mapping- technical expertise |
Impact | Ongoing |
Start Year | 2015 |
Description | UKB CVD OP |
Organisation | Queen Mary University of London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | UK Biobank: Associations between BMD, fracture and cardiovascular disease |
Collaborator Contribution | UK Biobank: Associations between BMD, fracture and cardiovascular disease |
Impact | UK Biobank: Associations between BMD, fracture and cardiovascular disease |
Start Year | 2014 |
Description | University of Helsinki |
Organisation | University of Helsinki |
Country | Finland |
Sector | Academic/University |
PI Contribution | Research collaboration |
Collaborator Contribution | Clinical Impact |
Impact | Clinical impact |
Start Year | 2006 |
Description | University of Oxford |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Research Collaboration |
Collaborator Contribution | Research Collaboration |
Impact | Clinical Impact |
Start Year | 2007 |
Description | VIBE |
Organisation | University of Bristol |
Department | MRC Integrative Epidemiology Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Scientific collaboration |
Collaborator Contribution | Scientific collaboration |
Impact | 2 abstracts |
Start Year | 2013 |
Description | WHO Clinical Consortium on Health Ageing |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Contribution to World Report on Ageing and Health, and project to operationalise concept of intrinsic capacity |
Collaborator Contribution | Organisation of WHO workshop on intrinsic capacity |
Impact | WHO Global Report on Ageing and Health |
Start Year | 2016 |
Title | PHENOTYPE PREDICTION BY DETERMINING THE METHYLATION STATUS OF GENES |
Description | Phenotypic characteristics selected from obesity and/or adiposity, bone health, and cardiovascular disease, may be predicted by determining the methylation status of one or more CpG dinucleotides of the, SLC6A4, CDKN2A, FEN1 and BACH1 genes. |
IP Reference | WO2015067952 |
Protection | Patent application published |
Year Protection Granted | 2015 |
Licensed | No |
Impact | EpiGen Consortium |
Title | PREDICTIVE USE OF CPG METHYLATION |
Description | RXRA for obesity or adiposity, body mass index and limb fat as an indicator of body fat distribution |
IP Reference | EP2391730 |
Protection | Patent application published |
Year Protection Granted | 2011 |
Licensed | No |
Impact | EpiGen Consortium |
Title | Phenotype prediction |
Description | Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual. |
IP Reference | EP2194143 |
Protection | Patent application published |
Year Protection Granted | 2010 |
Licensed | No |
Impact | EpiGen Consortium |
Title | Healthy Conversation Intervention |
Description | Healthy Conversation Intervention |
Type | Preventative Intervention - Behavioural risk modification |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Impact | Health and Wealth impacts |
Description | ESCEO Working Group |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus Cooper attended the ESCEO Working Group on September 9th 2022. |
Year(s) Of Engagement Activity | 2022 |
Description | Launch of the MRC Lifecourse Epidemiology Centre & MRC National Musculoskeletal Group |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | The launch of the MRC Lifecourse Epidemiology Centre and the MRC National Musculoskeletal Ageing Network was an online event. |
Year(s) Of Engagement Activity | 2022 |
URL | https://us06web.zoom.us/rec/play |
Description | Newspaper interview (Daily Mail, NCH) Vitamin D |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Increased understanding of vitamin D |
Year(s) Of Engagement Activity | 2014 |
Description | Presentation given at ESCEO Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus gave a presentation entitled "Optamising the prescription of oral Bisphosphonates" |
Year(s) Of Engagement Activity | 2022 |
Description | Press Release hosted on IOF website |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The IOF hosted a Press Release entitled 'New guidance for the assessment of Fracture Liaison Services at a patient outcome level.' Professor Cooper was quoted as saying: "A first fragility fracture is a strong predictor of secondary fractures, which are associated with morbidity, excess mortality, and enormous socioeconomic costs. Yet despite a wide range of effective anti-osteoporosis medications and the increase in the world's aged populations, the proportion of patients receiving adequate secondary fracture prevention is alarmingly low." |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.osteoporosis.foundation/news/new-guidance-assessment-fracture-liaison-services-patient-o... |
Description | Press Release hosted on IOF website |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The IOF website hosted a Press Release entitled: 'European countries face a costly 23% increase in fragility fractures by 2030.' Professor Cooper was quoted as saying: "In Europe, the lifetime risk of sustaining a life-threatening hip fracture is similar to the lifetime risk of a stroke. Yet as this study so clearly reveals, osteoporosis and fracture prevention remain markedly under-prioritized in health care policy across Europe. IOF calls on health authorities to take action and respond to the escalating fragility fracture crisis by prioritising care standards and funding to support the implementation of Fracture Liaison Services." |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.osteoporosis.foundation/news/european-countries-face-costly-23-increase-fragility-fractu... |
Description | Press Release hosted on IOF website |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The IOF website released a Press Release entitled, 'Worldwide IOF-ISCD survey of bone densitometry units published.' Professor Cooper was quoted as saying "This unique, ground-breaking study is exactly the sort of health quality assessment required in our field. It is a wonderful example of collaboration between IOF and ISCD to generate a unique global perspective." |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.osteoporosis.foundation/news/worldwide-iof-iscd-survey-bone-densitometry-units-published... |
Description | Press Release hosted on IOF website |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | There was a press release entitled Virtual IOF-ESCEO World Congress draws record attendance. This took place in August 2020. Professor Cooper was quoted as saying: "Affecting over 1.7 billion people globally, musculoskeletal disorders are the second greatest cause of disability as measured by years lived with disability. There is increasing evidence that the pandemic is having a detrimental impact on musculoskeletal health, due in part to less physical activity and the difficulty in accessing testing and maintaining continuity of treatment. Experts in the field are deeply concerned about the resulting impact on the long-term musculoskeletal health of older adults worldwide. The expected backlog in testing and treatment will certainly pose a challenge to the medical community. This is why, now more than ever, it is vital that IOF and ESCEO, as leading organizations in the field, continue to advance knowledge and education among health professionals through this global Congress". |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.osteoporosis.foundation/news/virtual-iof-esceo-world-congress-draws-record-attendance-20... |
Description | Press Release hosted on IOF website |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The IOF website gave a Press release entitled: 'Adjusting FRAX estimates to account for site of recent fracture.' Professor Cooper was quoted as saying: "There is a strong rationale for very early intervention immediately after a first fracture to avoid recurrent fractures, which place such a heavy burden on individuals and society as a whole. The possibility to adjust FRAX estimates for recency of fracture is therefore a significant development at many levels. For the physician it provides a new way to categorize a patient's risk, and to identify patients who may benefit from treatment with anabolic first regimens. Additionally, the probability adjustments will impact on FRAX-based guidance and be useful in health economic models that incorporate imminent risk." |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.osteoporosis.foundation/news/adjusting-frax-estimates-account-site-recent-fracture-20200... |
Description | Press Release hosted on IOF website |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The IOF hosted a Press Release entitled 'New Capture the Fracture® Partnership Announced.' |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.osteoporosis.foundation/news/new-capture-fracture-partnership-announced-20200616-1614 |
Description | REF 2021 University Results Presentation |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Cyrus attended the REF2021 University Results Presentation meeting on 9th May 2022. |
Year(s) Of Engagement Activity | 2022 |
Description | Sainsburys Magazine (NCH, osteoporosis) |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Increased understanding of bone health |
Year(s) Of Engagement Activity | 2014 |
Description | Southampton Women's Survey Celebration Event |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | As part of the 50th Anniversary of the NIHR BRC, the Southampton Women's Survey were chosen to represent some of the research that has taken place in Southampton. The BRC funded an evening at the City Art Gallery in Southampton for 50 SWS participants and their family or friends. The speakers who talked about the study findings were Prof. Cyrus Copper, Prof Keith Godfrey, Prof Janis Baird and Prof Hazel Inskip who wrote and sang a song at the end of the presentation whilst playing her ukulele. SWS staff in attendance and who organised the logistics for the event were research nurses, Julia Hammond, Nicole Minette, Karen McGill and Tina Horsfall. They received requests about further participation or involvement, the audience reported change in views, opinions or behaviours, requests for further information. Children were also recruited for PPI for the BRC. |
Year(s) Of Engagement Activity | 2022 |
Description | US magazine, NCH osteoporosis |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Increased understanding of bone health |
Year(s) Of Engagement Activity | 2014 |