The Enteroendocrine System in Health and Disease
Lead Research Organisation:
University of Cambridge
Abstract
The aims of our research are to understand how hormones from the gut influence appetite and blood glucose control.
After a meal, the gut produces hormones signalling to the brain to stop eating, and to the pancreas that it is time to release more insulin. One of these gut hormones has recently been developed as a new treatment for diabetes, and many people are interested in whether any other gut hormones could also be developed for the treatment of diabetes and obesity.
Our programme of research aims to understand how gut hormones are released after a meal, and whether it would be possible to alter their production as a new form of treatment. We study how individual hormone-producing cells detect nutrients, using techniques that allow us to monitor how single cells respond to stimuli in real time. By removing specific genes in mice, we can build up a picture of which genes are most important for how these gut cells work. The findings can then be used as a starting point for devising new ways to alter hormone release in humans.
After a meal, the gut produces hormones signalling to the brain to stop eating, and to the pancreas that it is time to release more insulin. One of these gut hormones has recently been developed as a new treatment for diabetes, and many people are interested in whether any other gut hormones could also be developed for the treatment of diabetes and obesity.
Our programme of research aims to understand how gut hormones are released after a meal, and whether it would be possible to alter their production as a new form of treatment. We study how individual hormone-producing cells detect nutrients, using techniques that allow us to monitor how single cells respond to stimuli in real time. By removing specific genes in mice, we can build up a picture of which genes are most important for how these gut cells work. The findings can then be used as a starting point for devising new ways to alter hormone release in humans.
Technical Summary
This programme addresses enteroendocrine cell physiology, identifying strategies to enhance secretion of gut hormones that regulate appetite and insulin release.
The gut endocrine system is increasingly recognised as a central player in the coordination of appetite, insulin release and post-prandial nutrient homeostasis. It likely underlies many of the beneficial physiological responses to gastric bypass surgery, and some of the secreted hormones have already been harnessed successfully for the treatment of diabetes and short bowel syndrome. Emerging therapies based on the secretion and action of gut peptides are predicted to be major players in the future treatment of metabolic disease.
Understanding the physiology of the gut endocrine system is critical for identifying novel strategies to modulate hormone release in humans and interpreting post-ingestive and post-bypass physiology. This is an area of research that has advanced dramatically in the past decade, with the introduction of technologies to identify, isolate and interrogate enteroendocrine cells in murine models. As a result, some general principles of stimulus detection in incretin-secreting K- and L-cells have now been established, but there are many unanswered questions such as the relative importance of different enteroendocrine signalling pathways in vivo, the functional overlap between different enteroendocrine cell types, and the impact of genetics, diet and metabolic disease on the enteroendocrine system?
These questions will be addressed here using a candidate gene approach. Genes for functional evaluation will be selected based on their predicted effects on whole body physiology, enteroendocrine cell development, nutrient sensing and/or secretion. State-of-the-art optical and electrophysiological recording techniques will be utilised to monitor dynamic physiological responses of single identified enteroendocrine cells in primary culture, and the intact gut-brain-pancreatic axis will be assessed in vivo using genetically modified mouse models. Promising enteroendocrine target receptors and pathways will be further evaluated for translational effects on appetite and glucose homeostasis in humans.
The gut endocrine system is increasingly recognised as a central player in the coordination of appetite, insulin release and post-prandial nutrient homeostasis. It likely underlies many of the beneficial physiological responses to gastric bypass surgery, and some of the secreted hormones have already been harnessed successfully for the treatment of diabetes and short bowel syndrome. Emerging therapies based on the secretion and action of gut peptides are predicted to be major players in the future treatment of metabolic disease.
Understanding the physiology of the gut endocrine system is critical for identifying novel strategies to modulate hormone release in humans and interpreting post-ingestive and post-bypass physiology. This is an area of research that has advanced dramatically in the past decade, with the introduction of technologies to identify, isolate and interrogate enteroendocrine cells in murine models. As a result, some general principles of stimulus detection in incretin-secreting K- and L-cells have now been established, but there are many unanswered questions such as the relative importance of different enteroendocrine signalling pathways in vivo, the functional overlap between different enteroendocrine cell types, and the impact of genetics, diet and metabolic disease on the enteroendocrine system?
These questions will be addressed here using a candidate gene approach. Genes for functional evaluation will be selected based on their predicted effects on whole body physiology, enteroendocrine cell development, nutrient sensing and/or secretion. State-of-the-art optical and electrophysiological recording techniques will be utilised to monitor dynamic physiological responses of single identified enteroendocrine cells in primary culture, and the intact gut-brain-pancreatic axis will be assessed in vivo using genetically modified mouse models. Promising enteroendocrine target receptors and pathways will be further evaluated for translational effects on appetite and glucose homeostasis in humans.
Organisations
- University of Cambridge, United Kingdom (Collaboration, Lead Research Organisation)
- University of Edinburgh, United Kingdom (Collaboration)
- University of Gothenburg, Sweden (Collaboration)
- Mayo Clinic (Collaboration)
- Utrecht University (Collaboration)
- Lausanne University, Switzerland (Collaboration)
- Royal Netherlands Academy of Arts and Sciences (Collaboration)
- Wageningen University, Netherlands (Collaboration)
- University of Toronto (Collaboration)
- Novartis (Collaboration)
- Swiss Federal Institute of Technology (ETH), Zurich (Collaboration)
- F. Hoffmann-La Roche AG (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- Ulster University (Collaboration)
- Eli Lilly & Company Ltd (Collaboration)
- Danone (Collaboration)
- LGC Limited, United Kingdom (Collaboration)
- Harokopio University (Collaboration)
- Maastricht University (UM) (Collaboration)
- University of Lille (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- University Medical Centre Utrecht, Netherlands (Collaboration)
- Medical Research Council (Collaboration)
- Mercodia AB (Collaboration)
- University of Geneva, Switzerland (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- University of Aberdeen, United Kingdom (Collaboration)
- California Institute of Technology, United States (Collaboration)
- Takeda Cambridge Ltd (Collaboration)
- University of Cologne, Germany (Collaboration)
- Lund University (Collaboration)
- MedImmune (Collaboration)
- Encap Drug Delivery (Collaboration)
- Addenbrooke's Hospital (Collaboration)
Publications
Adriaenssens A
(2015)
A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.
in Endocrinology
Adriaenssens AE
(2016)
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
in Diabetologia
Adriaenssens AE
(2018)
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract.
in Comprehensive Physiology
Anesten F
(2016)
Preproglucagon neurons in the hindbrain have IL-6 receptor-a and show Ca2+ influx in response to IL-6.
in American journal of physiology. Regulatory, integrative and comparative physiology
Arora T
(2018)
Microbial regulation of the L cell transcriptome.
in Scientific reports
Augustine V
(2018)
Hierarchical neural architecture underlying thirst regulation.
in Nature
Beumer J
(2018)
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.
in Nature cell biology
Biggs EK
(2017)
Scaling it down: new in vitro tools to get the balance right.
in The Biochemical journal
Biggs EK
(2018)
Development and characterisation of a novel glucagon like peptide-1 receptor antibody.
in Diabetologia
| Description | JDRF UK Beta Cell Renewal Roundtable |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | MRC Workshop on Neuroscience of Obesity: Gut-brain communication |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | Addenbrooke's Charitable Trust Fellowship (Geoff Roberts) |
| Amount | £52,000 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2017 |
| Description | BBSRC DTP PhD studentship (Ming Yang) |
| Amount | £95,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2019 |
| Description | BBSRC FTMA to Juraj Rievaj |
| Amount | £14,656 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 07/2018 |
| Description | BBSRC iCASE |
| Amount | £105,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | BBSRC iCASE |
| Amount | £145,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | BBSRC iCASE studentship partnered with MedImmune (Sam Galvin) |
| Amount | £95,196 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2020 |
| Description | Bakala Foundation Scholarship (Cristian Riccio) |
| Amount | £15,000 (GBP) |
| Organisation | Zdenek and Michaela Bakala foundation |
| Sector | Charity/Non Profit |
| Country | Switzerland |
| Start | 08/2014 |
| End | 07/2015 |
| Description | British Society for Neuroendocrinology small grant (Juraj Rievaj) |
| Amount | £3,500 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 06/2017 |
| Description | DAAD-PROMOS-Stipend for Ms Friederike Uhlig |
| Amount | € 1,725 (EUR) |
| Organisation | University of Hohenheim |
| Sector | Academic/University |
| Country | Germany |
| Start | 09/2013 |
| End | 12/2013 |
| Description | EASD travel grant |
| Amount | € 300 (EUR) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Sector | Charity/Non Profit |
| Country | European Union (EU) |
| Start | 10/2018 |
| End | 10/2018 |
| Description | EFSD |
| Amount | € 122,000 (EUR) |
| Funding ID | rg89241 |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 06/2017 |
| End | 11/2018 |
| Description | EFSD/Boehringer Ingelheim Programme |
| Amount | € 100,000 (EUR) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 08/2014 |
| End | 07/2016 |
| Description | EMBO Short Term Fellowship (Catalin Chimerel) |
| Amount | € 7,500 (EUR) |
| Organisation | European Molecular Biology Organisation |
| Sector | Learned Society |
| Country | European Union (EU) |
| Start | 09/2016 |
| End | 12/2016 |
| Description | Early career grant to Juraj Rievaj |
| Amount | £8,588 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 06/2018 |
| Description | Early career grant to Van Lu |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 07/2018 |
| Description | G/R, Joint Wellcome Trust Senior Investigators |
| Amount | £1,900,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 06/2020 |
| Description | Lister Summer Studentship |
| Amount | £1,600 (GBP) |
| Organisation | Lister Institute of Preventive Medicine |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2013 |
| End | 08/2013 |
| Description | MedImmune PhD studentship programme |
| Amount | £96,074 (GBP) |
| Organisation | MedImmune |
| Sector | Private |
| Country | United States |
| Start | 10/2014 |
| End | 09/2018 |
| Description | Medimmune grant |
| Amount | £272,857 (GBP) |
| Organisation | MedImmune |
| Sector | Private |
| Country | United States |
| Start | 06/2015 |
| End | 08/2017 |
| Description | Project Support Grant to Juraj Rievaj |
| Amount | £3,680 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2018 |
| Description | Royal College of Surgeons Research Fellowship |
| Amount | £20,000 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2018 |
| Description | Society for Endocrinology Early Career Grant (Arianna Psichas) |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2016 |
| Description | Society for Endocrinology Early Career Grant (Catalin Chimerel) |
| Amount | £9,924 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 05/2017 |
| Title | G/R, Measurement of GLP-1 from epithelial sheets |
| Description | Optimising the use of Ussing chambers technology for the reliable measurement of basolateral GLP-1 secretion from epithelial sheets |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Method allowed to distinguish between apical and basolateral effect of various drugs on GLP-1 secretion (Brighton et al, 2015) |
| URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606749/ |
| Title | GIP-Venus transgenic mouse |
| Description | Venus driven by the GIP promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Shared with some other groups and licensed |
| Title | GLU-Cre transgenic mouse |
| Description | Cre-recombinase driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | Shared with other groups and licensed to industry |
| Title | GLU-Venus transgenic mouse |
| Description | Fluorescent protein driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | Shared with many collaborators around the world and licensed to industry |
| Title | Glu-CreERT2 |
| Description | Tamoxifen-inducible cre expression driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Shared with academic collaborators and licensed to industry |
| Title | Glu-Epac2camps transgenic mouse |
| Description | transgenic mice in which the cAMP FRET sensor Epac2camps is driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Shared with collaborators |
| Title | sst-cre transgenic mouse |
| Description | Cre-recombinase driven by the somatostatin promoter in a transgenic mouse model |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Shared with academic collaborators |
| Description | Acosta |
| Organisation | Mayo Clinic |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Training provided to Acosta's group |
| Collaborator Contribution | Analysis of patient samples |
| Impact | None |
| Start Year | 2018 |
| Description | Brubaker lab |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Mouse models and discussion |
| Collaborator Contribution | Experimentation and project design |
| Impact | Publication |
| Start Year | 2015 |
| Description | FG, Susan Jebb, HNR |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Nutrition Research Unit |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Assays and discussion |
| Collaborator Contribution | Ran project |
| Impact | Publication, PMID: 26054049 |
| Start Year | 2014 |
| Description | Full4Health |
| Organisation | Danone |
| Country | France |
| Sector | Private |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Encap Drug Delivery |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Harokopio University |
| Country | Greece |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Maastricht University (UM) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Norwegian University of Science and Technology (NTNU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University Medical Center Utrecht (UMC) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Cologne |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Wageningen |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | G/R Bertie Goettgens, Single Cell RNAseq |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments |
| Collaborator Contribution | Experiments |
| Impact | none yet |
| Start Year | 2015 |
| Description | G/R, Bart Staels, FXR |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Experiments and data |
| Collaborator Contribution | Experiments |
| Impact | Publication, PMID: 26134028 |
| Start Year | 2014 |
| Description | G/R, Eelco de Koning, gut organoids |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) Publications: PMIDs: 25500886, 24130334 |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25500886, 2413033 |
| Start Year | 2013 |
| Description | G/R, Fredrik Backhed, Germ free/ gut hormones |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Provision of germ free animals / experiments |
| Impact | none as yet |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | Harokopio University |
| Country | Greece |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Holst perfused intestine and pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Experimental ideas and data |
| Collaborator Contribution | Experiments |
| Impact | Publications, PMIDs: 26280129, 24525020, 26483393 |
| Start Year | 2014 |
| Description | G/R, Karolina Skibicka, central GLP-1 |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 25793511 |
| Start Year | 2013 |
| Description | G/R, Kristina Schoonjans, GPBAR1 |
| Organisation | University of Lausanne |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments and ideas |
| Collaborator Contribution | GM mouse model |
| Impact | Publication, PMID: 26280129 |
| Start Year | 2015 |
| Description | G/R, Medimmune proteomics |
| Organisation | MedImmune |
| Country | United States |
| Sector | Private |
| PI Contribution | We will develop mass spec gut hormone detection |
| Collaborator Contribution | Financial and intellectual |
| Impact | none as yet |
| Start Year | 2015 |
| Description | G/R, Medimmune studentship |
| Organisation | MedImmune |
| Country | United States |
| Sector | Private |
| PI Contribution | joint supervision of PhD student |
| Collaborator Contribution | joint supervision of PhD student |
| Impact | too early in the studentship |
| Start Year | 2014 |
| Description | G/R, Novartis RNAseq |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | Providing information, developing new techniques |
| Collaborator Contribution | Development of new techniques |
| Impact | Developed a priliminary technique to isolate RNA from human enteroednocrine cells |
| Start Year | 2012 |
| Description | G/R, Patrik Rorsman, islet studies |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25172946, 24315372, 20519125 |
| Start Year | 2009 |
| Description | G/R, Pedro Herrera, Islet transdifferentiation |
| Organisation | University of Geneva |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experimental contributions |
| Impact | Publication: PMID 25141178 |
| Start Year | 2013 |
| Description | G/R, Peter Spegel, islet studies |
| Organisation | Lund University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 25731850 |
| Start Year | 2015 |
| Description | G/R, Roche TAAR1 |
| Organisation | F. Hoffmann-La Roche AG |
| Country | Global |
| Sector | Private |
| PI Contribution | Experiments |
| Collaborator Contribution | provision of information and research compounds |
| Impact | Publication: PMID 26241122 |
| Start Year | 2013 |
| Description | G/R, Thue Schwartz, enteroendocrine GPCRome |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25453189, 26483393 |
| Start Year | 2010 |
| Description | G/R, Yvan Gosmain, islet studies |
| Organisation | University of Geneva |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 26696123 |
| Start Year | 2014 |
| Description | GIP receptor localisation and function |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We generated a gipr knockin mouse, which has been shipped to Toronto |
| Collaborator Contribution | Analysis of the genetically modified mouse in Toronto |
| Impact | None to date |
| Start Year | 2016 |
| Description | Gastrectomy clinicians |
| Organisation | Addenbrooke's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Physiological studies on humans after gastrectomy plus in vitro analysis of tissue samples |
| Collaborator Contribution | Identification of suitable patients |
| Impact | Publications |
| Start Year | 2015 |
| Description | Generation of organoids from transgenic models |
| Organisation | Royal Netherlands Academy of Arts and Sciences |
| Department | Hubrecht Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We provided tissue from transgenic mouse models |
| Collaborator Contribution | Collaborators will generate organoids for use in their research programme |
| Impact | None to date |
| Start Year | 2016 |
| Description | Holst perfused pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Ideas for experiments |
| Collaborator Contribution | Perfused pancreas to test ideas developed in Cambridge |
| Impact | Publication |
| Start Year | 2015 |
| Description | Human EEC isolation |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | Development of methodology to purify human L-cells |
| Collaborator Contribution | Method development |
| Impact | Methods still under optimisation |
| Start Year | 2011 |
| Description | LGC peptidomics |
| Organisation | LGC Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Supporting a BBSRC iCASE studentship |
| Collaborator Contribution | Analysis and training |
| Impact | One publication to date |
| Start Year | 2017 |
| Description | Larraufie Paris lab |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Public |
| PI Contribution | Experimentation |
| Collaborator Contribution | Experimentation and project planning |
| Impact | Publications |
| Start Year | 2016 |
| Description | Lilly GIPR |
| Organisation | Eli Lilly & Company Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Research in the field of central GIPR signalling |
| Collaborator Contribution | Tool compounds and unpublished data |
| Impact | None yet |
| Start Year | 2018 |
| Description | MedImmune PhD studentship GLP1R |
| Organisation | MedImmune |
| Country | United States |
| Sector | Private |
| PI Contribution | Joint PhD student with supervisors at Medimmune generating and characterising GLP1R antibodies |
| Collaborator Contribution | MedImmune will provide training and tools |
| Impact | One publication to date |
| Start Year | 2014 |
| Description | Medimmune BBSRC iCASE (Galvin) |
| Organisation | MedImmune |
| Department | MedImmune Cambridge |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Supervision of PhD student |
| Collaborator Contribution | Joint supervision of student, training, peptide synthesis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Mercodia assay validation |
| Organisation | Mercodia AB |
| PI Contribution | Mass spec analysis to validate Mercodia's glucagon assay. Measurement of patient samples using glucagon and glicentin assays to establish the cause of assay cross reactivity |
| Collaborator Contribution | Provision of assays and suggestions for protocol changes to remove cross-reactivity |
| Impact | Mercodia published a white paper outlining the collaboration and how it has impacted on the use of the glucagon assay |
| Start Year | 2018 |
| Description | Pancreatic islet studies |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mouse models, technical and practical assistance with FACS sorting, qRT-PCR analysis |
| Collaborator Contribution | Initiated project and produced samples for analysis |
| Impact | Published manuscripts |
| Start Year | 2010 |
| Description | Shin Lee, ETH Zurich |
| Organisation | ETH Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mice |
| Collaborator Contribution | Analysis of transgenic mice |
| Impact | None to date |
| Start Year | 2016 |
| Description | Takeda collaboration |
| Organisation | Takeda Cambridge Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have initiated 2 projects that have been pursued in collaboration with Takeda |
| Collaborator Contribution | Takeda have knockout mouse models that have been given to the project, and researchers at Takeda have carried out in vivo mouse phenotyping that has contributed to the final output. |
| Impact | PMIDs: 25028498 22190648 |
| Start Year | 2009 |
| Description | Ulster, transgenic mice |
| Organisation | Ulster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration involving transgenic mouse models generated in Cambridge, and shipped to Ulster |
| Collaborator Contribution | Collaborators will work with the transgenic model |
| Impact | None to date |
| Start Year | 2016 |
| Description | Yuki Oka |
| Organisation | California Institute of Technology |
| Department | Division of Biology and Biological Engineering (BBE) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of mouse models |
| Collaborator Contribution | Research contribution |
| Impact | Nature publication |
| Start Year | 2017 |
| Description | indole as a signalling molecule from gut microbiota |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A visiting scientist from the department of physics joined our lab part time for 6 months to investigate the physiological role of indole. We provided training, techniques and resources |
| Collaborator Contribution | Our partner provided the salary of the visiting post-doc, and intellectual support |
| Impact | A manuscript is in press |
| Start Year | 2013 |
| Title | GIP-Cre |
| Description | GIP-Cre genetically modified mouse model |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | MTAs in place for sharing with academic collaborators |
| Title | GLP1R-Cre |
| Description | Transgenic mice expressing Cre-recombinase driven by the GLP-1 receptor promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | None known to date |
| Title | GLU-Cre mice |
| Description | Transgenic mice expressing cre-recombinase driven by the proglucagon promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | No known impact to date |
| Title | GLU-CreERT2 |
| Description | Transgenic mice expressing tamoxifen-inducible cre-recombinase driven by the proglucagon promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | None known to date |
| Description | 13th annual Biomarkers Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | An industrial congress bringing together a variety of industrial technologies for the measurement of biomarkers |
| Year(s) Of Engagement Activity | 2018 |
| Description | ADA poster 2014 (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting questions |
| Year(s) Of Engagement Activity | 2014 |
| Description | BBC Radio Cambridgeshire Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with BBC Radio Cambridgeshire, to discuss gut brain signalling, and the upcoming public lecture at the Science Festival |
| Year(s) Of Engagement Activity | 2017 |
| Description | Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Big Biology Day - engagement activities explaining metabolic research to families |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge Big Weekend |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | hands on events loosley based on the Units research |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cambridge Network recruitment event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay presented at the Cambridge Network recruitment event: "Proglucagon peptide analysis in post gastrectomy patients - bioanalysis or gut feeling?" to people interested in science jobs in the Cambridge area. (asked to present by Mike Van Der Merwe at LGC) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Science Festival - Right Diet debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Audience reported change in views, opinions or behaviours |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.sciencefestival.cam.ac.uk/events/there-right-diet-me |
| Description | Cambridge Science Festival - family activities |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Drop-in hands-on event for families and children. Sparked questions from children and parents |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | Cambridge Science Festival 2014 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands on activity for children sparked discussions with children and parents Very positive feedback from public |
| Year(s) Of Engagement Activity | 2014 |
| Description | Cambridge Science Festival Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public Lecture: Gribble and Fletcher. "Inside out: how the gut changes the brain's view of the world". Followed by questions from the public |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge Science festival, family weekends |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | promoted interest in science taking place at the inst |
| Year(s) Of Engagement Activity | 2013,2014,2015 |
| Description | Careers day at Presdales Secondary School (Cheryl Brighton) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Speed-dating job careers advise sparked interesting and stimulating discussions. Some pupils expressed interest in a career in Science - to early to judge longterm impact. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Diabetes UK Aug 2014 (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Discussed new treatments for diabetes and their benefits and limitations Patients expressed interest that we are performing research that might improve future therapies |
| Year(s) Of Engagement Activity | 2014 |
| Description | Diabetes UK July 2014 Huntingdon group (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Many questions answered about diabetes treatments Patients better informed about diabetes treatments |
| Year(s) Of Engagement Activity | 2014 |
| Description | EASD poster 2013 (AEA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interesting discussions around data presented on poster Interesting discussion and future collaborations discussed |
| Year(s) Of Engagement Activity | 2013 |
| Description | EASD poster 2013 (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | EASD poster 2014 (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting discussion and collaboration Triggered interesting discussion |
| Year(s) Of Engagement Activity | 2014 |
| Description | FG, BBC Horizon Special - Right Diet for You |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 3-part BBC2 horizon series |
| Year(s) Of Engagement Activity | 2015 |
| Description | FG, BBC Radio 4 programme, Inside Health |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 'Discussion of publication: "Diagnosis of gestational diabetes: falling through the net" |
| Year(s) Of Engagement Activity | 2015 |
| Description | FG, Press release, article covered by BBC News and multiple international medical publications |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | 'Discussion of publication: "Diagnosis of gestational diabetes: falling through the net" |
| Year(s) Of Engagement Activity | 2015 |
| Description | Familial Gastric Cancer Study Day (Geoff Roberts) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | 80-100 participants and family members, with familial gastric cancer, attended a study day to learn more about current research and practice. Geoff Roberts was one of the invited speakers. A number of patients expressed an interest in participating in our future research |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited seminar at Genomics Institute of Novartis Research Foundation (FMG) 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion about Novartis' drug development program The researchers at Novartis used my expertise to help in their ongoing drug development program targeting intestinal enteroendocrine cells |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited seminar at Technische Universität München (FMG) 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Sparked discussion and potential collaboration |
| Year(s) Of Engagement Activity | 2013 |
| Description | Invited seminar at UCL (FMG) 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered discussion and further experiments that we tried together Further joint experiments following discussions on the day |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited talk at Paris Descartes (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | The speaker, P.Richards, was offered a research position on the basis of this talk Career progression for P.Richards |
| Year(s) Of Engagement Activity | 2014 |
| Description | MRC Centenary Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A hands-on practical demonstration, devised and manned by researchers from our group. The practical was based on sweet taste perception and targeted at members of the public. Engaged participation and interesting discussions with the public Well received from feedback |
| Year(s) Of Engagement Activity | 2013 |
| Description | MRL Science Slam |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The presenters (a post doc and student together) won a prize for their presentation |
| Year(s) Of Engagement Activity | 2018 |
| Description | Oxfordshire Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Audience reported change in views, opinions or behaviours |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.sciencefestival.cam.ac.uk/events/there-right-diet-me |
| Description | Professional PhD Networking forum AgroParistech and ABIES doctoral school Doc'Avenir |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Pierre Larraufie: Professional PhD Networking forum AgroParistech and ABIES doctoral school Doc'Avenir, 2017, Round table invited speaker about positions and career after a PhD. |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit (CM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A practical demonstration and associated discussion of the gut, presented by 2 of our PhD students to pupils at a local school. Good feedback |
| Year(s) Of Engagement Activity | 2013 |
| Description | Science lesson at primary school (CLM) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Triggered interesting discussions Greater interest in science and medicine |
| Year(s) Of Engagement Activity | 2012 |
| Description | Seminar at University of Sheffield (FMG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interesting discussion and plans for future collaboration The Sheffield group have employed one of our previous summer students to do a PhD, and we plan to work together on gut hormone effects on intestinal afferent nerves |
| Year(s) Of Engagement Activity | 2014 |
| Description | Stimulating innovation, experiences working with industry (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Stimulated discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | Summer school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Alison Douglas Summer School, for ~30 early career researchers from around Europe. I led an interactive morning session on gut hormones. Very positive feedback received (scored as best presentation from feedback forms) |
| Year(s) Of Engagement Activity | 2013 |
| Description | Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay was Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course. A three day course held at Loughborough University, focussed on the dissemination of knowledge for developing bioanalytical methodologies for large molecule analytes. |
| Year(s) Of Engagement Activity | 2017 |
| Description | WT PhD Studentship meeting (London 2013) (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | poster presentation |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered discussion |
| Year(s) Of Engagement Activity | 2013 |