The Enteroendocrine System in Health and Disease
Lead Research Organisation:
University of Cambridge
Abstract
The aims of our research are to understand how hormones from the gut influence appetite and blood glucose control.
After a meal, the gut produces hormones signalling to the brain to stop eating, and to the pancreas that it is time to release more insulin. One of these gut hormones has recently been developed as a new treatment for diabetes, and many people are interested in whether any other gut hormones could also be developed for the treatment of diabetes and obesity.
Our programme of research aims to understand how gut hormones are released after a meal, and whether it would be possible to alter their production as a new form of treatment. We study how individual hormone-producing cells detect nutrients, using techniques that allow us to monitor how single cells respond to stimuli in real time. By removing specific genes in mice, we can build up a picture of which genes are most important for how these gut cells work. The findings can then be used as a starting point for devising new ways to alter hormone release in humans.
After a meal, the gut produces hormones signalling to the brain to stop eating, and to the pancreas that it is time to release more insulin. One of these gut hormones has recently been developed as a new treatment for diabetes, and many people are interested in whether any other gut hormones could also be developed for the treatment of diabetes and obesity.
Our programme of research aims to understand how gut hormones are released after a meal, and whether it would be possible to alter their production as a new form of treatment. We study how individual hormone-producing cells detect nutrients, using techniques that allow us to monitor how single cells respond to stimuli in real time. By removing specific genes in mice, we can build up a picture of which genes are most important for how these gut cells work. The findings can then be used as a starting point for devising new ways to alter hormone release in humans.
Technical Summary
This programme addresses enteroendocrine cell physiology, identifying strategies to enhance secretion of gut hormones that regulate appetite and insulin release.
The gut endocrine system is increasingly recognised as a central player in the coordination of appetite, insulin release and post-prandial nutrient homeostasis. It likely underlies many of the beneficial physiological responses to gastric bypass surgery, and some of the secreted hormones have already been harnessed successfully for the treatment of diabetes and short bowel syndrome. Emerging therapies based on the secretion and action of gut peptides are predicted to be major players in the future treatment of metabolic disease.
Understanding the physiology of the gut endocrine system is critical for identifying novel strategies to modulate hormone release in humans and interpreting post-ingestive and post-bypass physiology. This is an area of research that has advanced dramatically in the past decade, with the introduction of technologies to identify, isolate and interrogate enteroendocrine cells in murine models. As a result, some general principles of stimulus detection in incretin-secreting K- and L-cells have now been established, but there are many unanswered questions such as the relative importance of different enteroendocrine signalling pathways in vivo, the functional overlap between different enteroendocrine cell types, and the impact of genetics, diet and metabolic disease on the enteroendocrine system?
These questions will be addressed here using a candidate gene approach. Genes for functional evaluation will be selected based on their predicted effects on whole body physiology, enteroendocrine cell development, nutrient sensing and/or secretion. State-of-the-art optical and electrophysiological recording techniques will be utilised to monitor dynamic physiological responses of single identified enteroendocrine cells in primary culture, and the intact gut-brain-pancreatic axis will be assessed in vivo using genetically modified mouse models. Promising enteroendocrine target receptors and pathways will be further evaluated for translational effects on appetite and glucose homeostasis in humans.
The gut endocrine system is increasingly recognised as a central player in the coordination of appetite, insulin release and post-prandial nutrient homeostasis. It likely underlies many of the beneficial physiological responses to gastric bypass surgery, and some of the secreted hormones have already been harnessed successfully for the treatment of diabetes and short bowel syndrome. Emerging therapies based on the secretion and action of gut peptides are predicted to be major players in the future treatment of metabolic disease.
Understanding the physiology of the gut endocrine system is critical for identifying novel strategies to modulate hormone release in humans and interpreting post-ingestive and post-bypass physiology. This is an area of research that has advanced dramatically in the past decade, with the introduction of technologies to identify, isolate and interrogate enteroendocrine cells in murine models. As a result, some general principles of stimulus detection in incretin-secreting K- and L-cells have now been established, but there are many unanswered questions such as the relative importance of different enteroendocrine signalling pathways in vivo, the functional overlap between different enteroendocrine cell types, and the impact of genetics, diet and metabolic disease on the enteroendocrine system?
These questions will be addressed here using a candidate gene approach. Genes for functional evaluation will be selected based on their predicted effects on whole body physiology, enteroendocrine cell development, nutrient sensing and/or secretion. State-of-the-art optical and electrophysiological recording techniques will be utilised to monitor dynamic physiological responses of single identified enteroendocrine cells in primary culture, and the intact gut-brain-pancreatic axis will be assessed in vivo using genetically modified mouse models. Promising enteroendocrine target receptors and pathways will be further evaluated for translational effects on appetite and glucose homeostasis in humans.
Organisations
- University of Cambridge, United Kingdom (Lead Research Organisation)
- Catholic University of Louvain, Belgium (Collaboration)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- University of Gothenburg, Sweden (Collaboration)
- Mayo Clinic (Collaboration)
- Utrecht University (Collaboration)
- Lausanne University, Switzerland (Collaboration)
- Royal Netherlands Academy of Arts and Sciences (Collaboration)
- Wageningen University & Research (Collaboration)
- University of Toronto (Collaboration)
- University of Cambridge (Collaboration)
- AstraZeneca plc (Collaboration)
- Novartis (Collaboration)
- Swiss Federal Institute of Technology (ETH), Zurich (Collaboration)
- F. Hoffmann-La Roche AG (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Eli Lilly & Company Ltd (Collaboration)
- Danone (Collaboration)
- LGC Limited, United Kingdom (Collaboration)
- Harokopio University (Collaboration)
- Maastricht University (UM) (Collaboration)
- University of Lille (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- University Medical Centre Utrecht, Netherlands (Collaboration)
- Medical Research Council (Collaboration)
- Mercodia AB (Collaboration)
- University of Geneva, Switzerland (Collaboration)
- Autonomous University of Madrid, Spain (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- University of Aberdeen, United Kingdom (Collaboration)
- Takeda Cambridge Ltd (Collaboration)
- University of Cologne, Germany (Collaboration)
- California Institute of Technology, United States (Collaboration)
- Florida State University, United States (Collaboration)
- Lund University (Collaboration)
- Encap Drug Delivery (Collaboration)
- Ulster University (Collaboration)
- Addenbrooke's Hospital (Collaboration)
Publications
Adriaenssens A
(2015)
A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.
in Endocrinology
Adriaenssens AE
(2016)
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
in Diabetologia
Adriaenssens AE
(2019)
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
in Cell metabolism
Adriaenssens AE
(2020)
The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system.
in Peptides
Adriaenssens AE
(2018)
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract.
in Comprehensive Physiology
Anesten F
(2016)
Preproglucagon neurons in the hindbrain have IL-6 receptor-a and show Ca2+ influx in response to IL-6.
in American journal of physiology. Regulatory, integrative and comparative physiology
Arora T
(2018)
Microbial regulation of the L cell transcriptome.
in Scientific reports
Ast J
(2020)
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
in Nature communications
Augustine V
(2018)
Hierarchical neural architecture underlying thirst regulation
in Nature
| Description | JDRF UK Beta Cell Renewal Roundtable |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | MRC Workshop on Neuroscience of Obesity: Gut-brain communication |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | Addenbrooke's Charitable Trust Fellowship (Geoff Roberts) |
| Amount | £52,000 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2017 |
| Description | BBSRC DTP PhD studentship (Ming Yang) |
| Amount | £95,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2019 |
| Description | BBSRC FTMA to Juraj Rievaj |
| Amount | £14,656 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 07/2018 |
| Description | BBSRC iCASE |
| Amount | £145,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2022 |
| Description | BBSRC iCASE |
| Amount | £105,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2022 |
| Description | BBSRC iCASE studentship partnered with MedImmune (Sam Galvin) |
| Amount | £95,196 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | Bakala Foundation Scholarship (Cristian Riccio) |
| Amount | £15,000 (GBP) |
| Organisation | Zdenek and Michaela Bakala foundation |
| Sector | Charity/Non Profit |
| Country | Switzerland |
| Start | 07/2014 |
| End | 07/2015 |
| Description | British Society for Neuroendocrinology small grant (Juraj Rievaj) |
| Amount | £3,500 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 06/2017 |
| Description | Covid plasma LC-MS analysis |
| Amount | £4,875 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 07/2020 |
| Description | DAAD-PROMOS-Stipend for Ms Friederike Uhlig |
| Amount | € 1,725 (EUR) |
| Organisation | University of Hohenheim |
| Sector | Academic/University |
| Country | Germany |
| Start | 08/2013 |
| End | 12/2013 |
| Description | EASD travel grant |
| Amount | € 300 (EUR) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 09/2018 |
| End | 10/2018 |
| Description | EFSD |
| Amount | € 122,000 (EUR) |
| Funding ID | rg89241 |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Academic/University |
| Country | Germany |
| Start | 05/2017 |
| End | 11/2018 |
| Description | EFSD Novo Nordisk Foundation future leaders award to Alice Adriaenssens |
| Amount | 500,000Â kr. (DKK) |
| Organisation | Novo Nordisk Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 01/2022 |
| End | 12/2027 |
| Description | EFSD Novo Nordisk programme |
| Amount | € 100,000 (EUR) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Academic/University |
| Country | Germany |
| Start | 03/2022 |
| End | 02/2023 |
| Description | EFSD/Boehringer Ingelheim Programme |
| Amount | € 100,000 (EUR) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Academic/University |
| Country | Germany |
| Start | 07/2014 |
| End | 07/2016 |
| Description | EMBO Short Term Fellowship (Catalin Chimerel) |
| Amount | € 7,500 (EUR) |
| Organisation | European Molecular Biology Organisation |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 08/2016 |
| End | 12/2016 |
| Description | ESE St Odile meeting grant |
| Amount | € 450 (EUR) |
| Organisation | European Society of Endocrinology |
| Sector | Learned Society |
| Country | European Union (EU) |
| Start | 09/2018 |
| End | 10/2018 |
| Description | Early career grant to Juraj Rievaj |
| Amount | £8,588 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 06/2018 |
| Description | Early career grant to Van Lu |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 07/2018 |
| Description | G/R, Joint Wellcome Trust Senior Investigators |
| Amount | £1,900,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2015 |
| End | 06/2020 |
| Description | GIPR in the CNS |
| Amount | $260,000 (USD) |
| Organisation | Eli Lilly & Company Ltd |
| Department | Neuroscience Eli Lilly |
| Sector | Private |
| Country | United States |
| Start | 01/2021 |
| End | 12/2021 |
| Description | Jo Lewis, BSN symposium support for Physiology 2019, Aberdeen, UK |
| Amount | £2,000 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2019 |
| Description | Jo Lewis, BSN symposium support for the ECR day at the BSN's annual conference, Glasgow, UK |
| Amount | £5,000 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2019 |
| Description | Jo Lewis, The Physiological Society satellite support for Physiology 2019, Aberdeen, UK |
| Amount | £20,000 (GBP) |
| Organisation | Physiological Society |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 07/2019 |
| End | 08/2019 |
| Description | Jo Lewis, The Physiological Society symposium support for Experimental Biology, Orlando, |
| Amount | £2,000 (GBP) |
| Organisation | Physiological Society |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 05/2019 |
| End | 06/2019 |
| Description | Lister Summer Studentship |
| Amount | £1,600 (GBP) |
| Organisation | Lister Institute of Preventive Medicine |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2013 |
| End | 08/2013 |
| Description | Liver disease peptidomics and proteomics |
| Amount | £24,350 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 12/2020 |
| Description | MedImmune PhD studentship programme |
| Amount | £96,074 (GBP) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2018 |
| Description | Medimmune grant |
| Amount | £272,857 (GBP) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 08/2017 |
| Description | Peptidomics of gestational diabetes |
| Amount | £3,400 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 03/2021 |
| Description | PhD in Clinical Biochemistry |
| Amount | £100,000 (GBP) |
| Funding ID | 2430172 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2020 |
| End | 03/2024 |
| Description | Project Support Grant to Juraj Rievaj |
| Amount | £3,680 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2018 |
| Description | Royal College of Surgeons Research Fellowship |
| Amount | £20,000 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 09/2018 |
| Description | Society for Endocrinology Early Career Grant (Arianna Psichas) |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2016 |
| Description | Society for Endocrinology Early Career Grant (Catalin Chimerel) |
| Amount | £9,924 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 05/2017 |
| Description | Targeting the gut in metabolic disease |
| Amount | £2,381,203 (GBP) |
| Funding ID | 220271/Z/20/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 07/2025 |
| Description | Wellcome PhD studentship to Elisabeth O'Flaherty |
| Amount | £180,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2022 |
| Description | Wellcome PhD studentship to Emily Miedzybrodzka |
| Amount | £180,824 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2021 |
| Title | G/R, Measurement of GLP-1 from epithelial sheets |
| Description | Optimising the use of Ussing chambers technology for the reliable measurement of basolateral GLP-1 secretion from epithelial sheets |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Method allowed to distinguish between apical and basolateral effect of various drugs on GLP-1 secretion (Brighton et al, 2015) |
| URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606749/ |
| Title | GIP-Venus transgenic mouse |
| Description | Venus driven by the GIP promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Shared with some other groups and licensed |
| Title | GLU-Cre transgenic mouse |
| Description | Cre-recombinase driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | Shared with other groups and licensed to industry |
| Title | GLU-Venus transgenic mouse |
| Description | Fluorescent protein driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | Shared with many collaborators around the world and licensed to industry |
| Title | Gipr-Cre transgenic mouse |
| Description | GIPR-Cre mouse enabling identification and manipulation of cells expressing Gipr |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Collaborations and publications. Research collaboration with Eli Lilly, investigating MOA of GLP1/GIP dual agonists (currently in phase 3 clinical trials) |
| Title | Glu-CreERT2 |
| Description | Tamoxifen-inducible cre expression driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Shared with academic collaborators and licensed to industry |
| Title | Glu-Epac2camps transgenic mouse |
| Description | transgenic mice in which the cAMP FRET sensor Epac2camps is driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Shared with collaborators |
| Title | Guanylin-Venus transgenic mouse |
| Description | Guanylin-venus mouse, enabling identification and characterisation of cells expressing guanylin |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Publication |
| Title | Insl5-rtTA mouse |
| Description | transgenic mouse Insl5-rtTA allowing identification and manipulation of INSL5-expressing cells |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | publications |
| Title | Rxfp4-Cre transgenic mouse |
| Description | Rxfp4-Cre transgenic mouse |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2015 |
| Provided To Others? | No |
| Impact | BBSRC-iCASE studentship joint with AstraZeneca to investigate central signalling involving Rxfp4 |
| Title | human GLU-Venus |
| Description | Human ileal organoids expressing the fluorescent reporter Venus driven by the proglucagon promoter |
| Type Of Material | Cell line |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | requests for collaborations |
| Title | sst-cre transgenic mouse |
| Description | Cre-recombinase driven by the somatostatin promoter in a transgenic mouse model |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Shared with academic collaborators |
| Title | Alteration of the plasma peptidome of gastrectomised patients during an OGTT |
| Description | Performing gastric bypass surgery on patients severely changes their gut hormone response to glucose. The plasma concentrations of Insulin and a number of associated incretin peptides are significantly raised shortly after ingestion of glucose. Typically the plasma concentrations of these peptides are monitored using immunoassays. A simple and high throughput plasma peptidomics approach was used to simulatneously monitor a large number of these peptides. Comparison of gastresctomised and control individuals showed significant increases of insulin, glucagon gene products, PYY and neurotensin. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD016690 |
| Title | Characterization of Guca2a expressing cells in the mouse intestine |
| Description | RNA seq of Guca2a expressing cells |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | openly accessible data |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128117 |
| Title | Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells |
| Description | Analysis of vesicular colocalisation by 3D-SIM |
| Type Of Material | Data analysis technique |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open method |
| Title | Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state |
| Description | Background: Gastrointestinal hormones regulate intestinal transit, control digestion, influence appetite and promote satiety. Altered production or action of gut hormones, including glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and peptide YY (PYY), may contribute to the biological basis of obesity and altered glucose homeostasis. However, challenges in analytical methodology and lack of clarity on expected values for healthy individuals has limited progress in this field. The aim of this study was to describe expected concentrations of gastrointestinal and pancreatic hormones in healthy volunteers following a standardised meal test (SMT) or 75g oral glucose tolerance test (OGTT). Methods: 28 healthy volunteers (12 men, 16 women; mean age 31.3 years; mean body mass index 24.9 kg/m2) were recruited to attend a hospital clinic on two occasions. Volunteers had blood sampling in the fasting state and were given, in randomised order, an oral glucose tolerance test (OGTT) and standardised mixed liquid meal test with venepuncture at timed intervals for 4 hours after ingestion. Analytical methods for gut and pancreatic hormones were assessed and optimised. Concentrations of gut and pancreatic hormones were measured and used to compile ranges of expected values. Results: Ranges of expected values were created for glucose, insulin, glucagon, GLP-1, GIP, PYY and free fatty acids in response to a standardised mixed liquid meal or OGTT. Intact Proinsulin and C-peptide levels were also measured following the OGTT. Conclusions: These ranges of expected values can now be used to compare gut hormone concentrations between healthy individuals and patient groups. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Openly accessible dataset |
| URL | https://www.repository.cam.ac.uk/handle/1810/312528 |
| Title | Glucose-dependent Insulinotropic polypeptide receptor-expressing cells in the hypothalamus regulate food intake |
| Description | Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and antagonism are effective strategies for inhibiting weight gain. To enable identification and manipulation of Gipr-expressing (Gipr) cells we created GIPR-Cre knock-in mice. As GIPR-agonists have recently been reported to suppress food intake we aimed to identify central mediators of this effect. Gipr cells were identified in the arcuate, dorsomedial, and paraventricular nuclei of the hypothalamus, as confirmed by RNAscope in mouse and human. Single cell RNAseq identified clusters of hypothalamic Gipr cells exhibiting transcriptomic signatures for mural, glial and neuronal cells, the latter expressing somatostatin, but little proopiomelanocortin or agouti-related peptide. Activation of Gq-DREADDs in hypothalamic Gipr cells suppressed food intake in vivo, which was not obviously additive with concomitant GLP1R activation. These data identify hypothalamic GIPR as a target for the regulation of energy balance. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134726 |
| Title | Human enteroendocrine cell transcriptomic profiling |
| Description | We purified two populations of human jejunal enteroendocrine cells (GLP1+ and GLP1-) by FACS and identified transcripts enriched in endocrine cell lineages. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114853 |
| Title | Human intestinal organoid cell transcriptomic profiling |
| Description | We purified two populations of human ileal enteroendocrine cells (Venus+ and Venus-) from mature differentiated hGLU-Venus organoids by FACS and identified transcripts enriched in endocrine cell lineages. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE148224 |
| Title | Mouse duodenal enteroendocrine transcriptome |
| Description | Using genetically modifed mice to express fluorescent reporter in proglucagon expressing cells (GluVenus) or in all enteroendocrine cells (NeuroD1), we purifed positive and negative cells by FACS from duodenal epithelial cells and identified transcripts enriched in positive populations |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open accessible dateset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114913 |
| Title | Peptidomic analysis of pancreatic neurodendocrine tumours (Glucagonoma) |
| Description | A peptidomic analysis of plasma from patients with well characterised pancreatic neuroendocrine tumours (PNET) was performed. A nano LC-MS analysis identified a number of peptides from the glucagon gene, which were idenfiried in a previous case study using multiple immunoassays. Peptides to other proteins involved in peptide secretion were also identified. Plasma from a second glucagonoma patient was analysed using a high flow approach, and this identified similar peptides to the nano analysis. In order to demonstrate the potential clinical application of LC-MS to characterising neuroendocrine tumours, a large cohort of plasma samples were analysed to demonstrate the ability of this approach to identify glucagonoma patients, and differentiate from a single insulinoma patient |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD008465 |
| Title | Peptidomics of sorted enteroendocrine cells from human organoids |
| Description | A human organoid culture system was set up to grow enteroendocrine cells with a venus labeled on the glucagon gene promoter sequence. This enabled the sorting of glucagon gene positive cells from negative cells, thereby enabling the enrichment of glucagon producing cells for study. Both Venus positive and venus negative cell populations were collected and their peptidome was assessed using nano LC-MS/MS |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | open data |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD017825 |
| Title | Peptidomics profiling of biopsies from the human jejunum before and after gastrectomy |
| Description | Profiling of the human jejunum peptidome before and after total gastrectomy. The study compares the peptidome of jejunum using intact mass spectrometry and database searching. These peptides included most gut hormones including proglucagon derived peptides, PYY, GIP, Motilin somatostatin and neurotensin amongst others. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD011498 |
| Title | Peptidomics profiling of human intestine |
| Description | The aim of the project is to generate a peptidomics map of gut hormone peptides along the gastrointestinal tract, starting with the stomach and including the duodenum, jejunum, ileum, ascending colon, sigmoid colon and rectum. The tissues would be collected after surgery and the peptide fraction extracted and anlysed by nano LC-MS to identify what peptide hormones are present. These data will then be used to compare against the human transcriptome, and also for comparison against equivent peptides from murine intestinal extracts. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD009788 |
| Title | Peptidomics profiling of murine intestine |
| Description | The aim of the project is to generate a peptidomics map of gut hormone peptides along the gastrointestinal tract, starting with the stomach and including the duodenum, jejunum, ileum, colon and rectum. The tissues would be collected after surgery and the peptide fraction extracted and anlysed by nano LC-MS to identify what peptide hormones are present. These data will then be used to compare against the murine transcriptome, and also for comparison against equivent peptides from human intestinal extracts. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD009796 |
| Title | Peptidomics profiling of the murine gut after vertical sleeve gastrectomy |
| Description | Profiling of the murine peptidome along the gastrointestinal tract and pancreas in vertical sleeve gastrectomy and sham operated mice. The study compares the peptidome of various portions of the GI tract using intact mass spectrometry and database searching. These peptides included most gut hormones including proglucagon derived peptides, PYY, GIP, somatostatin, neurotensin amongst others. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ebi.ac.uk/pride/archive/projects/PXD011455 |
| Title | SCFAs strongly stimulate PYY production in human enteroendocrine cells. |
| Description | Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes. PYY production is highest in enteroendocrine cells located in the distal intestine, mirroring the sites where high concentrations of short chain fatty acids (SCFAs) are produced by gut microbiota. We show here that propionate and butyrate strongly increased expression of PYY but not GCG in human cell line and intestinal primary culture models. The effect was predominantly attributable to the histone deacetylase inhibitory activity of SCFA and minor, but significant contributions of FFA2 (GPR43). Consistent with the SCFA-dependent elevation of PYY gene expression, we also observed increased basal and stimulated PYY hormone secretion. Interestingly, the transcriptional stimulation of PYY was specific to human-derived cell models and not reproduced in murine primary cultures. This is likely due to substantial differences in PYY gene structure between mouse and human. In summary, this study revealed a strong regulation of PYY production by SCFA that was evident in humans but not mice, and suggests that high fibre diets elevate plasma concentrations of the anorexigenic hormone PYY, both by targeting gene expression and hormone secretion. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Openly accessible data |
| URL | https://www.repository.cam.ac.uk/handle/1810/273309 |
| Title | Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice |
| Description | We report the different enteroendocrine populations in the large intestine in mice based on their transcriptomics profile. Hormone, receptor and transcription factors are analysed for differential expression between the different cell clusters to give a comprehensive view of the different characterisitcs of the distal entereondocrine cells |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137572 |
| Title | Single-cell RNA-sequencing reveals distinct populations of glucagon-like peptide-1 producing cells in the mouse upper small intestine |
| Description | Enteroendocrine L-cells release hormones that control metabolism and appetite and are targets under investigation for the treatment of diabetes and obesity. Understanding L-cell diversity and expression profiles is critical for identifying target receptors that will translate into altered hormone secretion. We performed single cell RNA sequencing of mouse L-cells from the upper small intestine to distinguish cellular populations, revealing that L-cells form 3 major clusters: a group with typical characteristics of classical L-cells, including high expression of Gcg and Pyy; a cell type overlapping with Gip-expressing K-cells; and a unique cluster expressing Tph1 and Pzp that was predominantly located in duodenal villi and co-produced 5HT. Expression of G-protein coupled receptors differed between clusters, suggesting the cell types are differentially regulated, and would be differentially targetable. Our findings support the emerging concept that many enteroendocrine cell populations are highly overlapping, with individual cells producing a range of peptides previously assigned to distinct cell types. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE108108 |
| Title | The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1 |
| Description | Exocytosis of the hormone, glucagon-like peptide-1 (GLP-1), by the intestinal L-cell is essential for the incretin effect after nutrient ingestion, and is critical for the actions of dipeptidylpeptidase IV inhibitors that enhance GLP-1 levels in patients with type 2 diabetes. 2-Photon microscopy revealed that exocytosis of GLP-1 is biphasic, with a 1(st) peak at 1-6min and a 2(nd) peak at 7-12min after stimulation with forskolin. Approximately 75% of the exocytotic events were represented by compound granule fusion, and the remainder were accounted for by full fusion of single granules, under basal and stimulated conditions. The core SNARE protein, syntaxin-1a (syn1a), was expressed by murine ileal L-cells. At the single L-cell level, 1(st) phase forskolin-induced exocytosis was reduced to basal (p |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | openly accessible data |
| URL | https://www.repository.cam.ac.uk/handle/1810/265784 |
| Title | The effect on the transcriptome by inhibition of mitochondrial function by metformin in intestinal cells |
| Description | We purified mouse duodenal cells from organoids derived from two different transgenic mouse lines (GIP-Cre tdRFP, SST-Cre tdRFP), and identified transcripts enriched in metformin-treated cells. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | openly accessible dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE165122 |
| Title | Transcriptomic profiling of alpha, beta, and delta cell populations provides new insights into the role of ghrelin in the pancreas |
| Description | Intra-islet crosstalk between islet cells is critical in orchestrating the body's response to changes in blood glucose levels, but is incompletely understood. In this study, we used transgenic mouse lines that allowed the purification and transcriptomic characterisation of alpha, beta, and delta cells, yielding an RNA-sequencing database that can be searched for regulatory proteins which are differentially expressed between cell types. As an illustrative example, we examined the expression of g-protein coupled receptors, and found that the ghrelin receptor, Ghsr, was highly expressed in delta cells compared to alpha and beta cells. GHSR excitation elicited increases in cytosolic calcium levels in primary delta cells. In the perfused pancreas, the application of ghrelin stimulated somatostatin secretion, correlating with a decrease in insulin and glucagon release, which was sensitive to somatostatin receptor antagonism. These results show that ghrelin acts specifically on delta cells within pancreatic islets to affect blood glucose regulation. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76017 |
| Title | Transcriptomics analysis of enteroendocrine cells after vertical sleeve gastrectomy |
| Description | We report here the transcriptome of sorted enteroendocrine cells from duodenum, ileum and colon from mice after vertical sleeve gastrectomy or sham operation, weight matched or not. We analyze the effect of region of origin and surgery and gene expression and found that only region of origin had an impact on EEC transcriptome |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121489 |
| Title | Transcriptomics analysis of human jejunal enteroendocrine cells after vertical sleeve gastrectomy |
| Description | We report here the transcriptome of a population enriched in enteroendocrine cells from human jejunum from patients before or after gastrectomy. We analyze the effect of surgery on gene expression and found very little effect on EEC transcriptome |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | open dataset |
| URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121486 |
| Description | Acosta |
| Organisation | Mayo Clinic |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Training provided to Acosta's group |
| Collaborator Contribution | Analysis of patient samples |
| Impact | None |
| Start Year | 2018 |
| Description | Ana Garcia nanoparticles |
| Organisation | Catholic University of Louvain |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | We are hosting a post doc in our group |
| Collaborator Contribution | Our partners are funding the project and provided the initial study design |
| Impact | Extension of the partnership from 1 year to 2 years |
| Start Year | 2020 |
| Description | Brubaker lab |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Mouse models and discussion |
| Collaborator Contribution | Experimentation and project design |
| Impact | Publication |
| Start Year | 2015 |
| Description | Central GLP1 signalling |
| Organisation | University College London |
| Department | Biosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Longstanding collaboration with Stefan Trapp's laboratory. We currently (Mar 21) have a joint application for further funding from MRC pending, which would financially contribute to the Reimann/Gribble laboratories. We frequently exchange ideas, have provided critical mouse models for this research and transcriptomic capabilities. |
| Collaborator Contribution | see above |
| Impact | Prof. Trapp's and the Reimann/Gribble laboratory have so far co-published 18 research papers on the topic (as on 10Mar21) |
| Description | FG, Susan Jebb, HNR |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Nutrition Research Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Assays and discussion |
| Collaborator Contribution | Ran project |
| Impact | Publication, PMID: 26054049 |
| Start Year | 2014 |
| Description | Full4Health |
| Organisation | Danone |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Encap Drug Delivery |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Harokopio University |
| Country | Greece |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Maastricht University (UM) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Norwegian University of Science and Technology (NTNU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University Medical Center Utrecht (UMC) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Cologne |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | G/R Bertie Goettgens, Single Cell RNAseq |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments |
| Collaborator Contribution | Experiments |
| Impact | none yet |
| Start Year | 2015 |
| Description | G/R, Bart Staels, FXR |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Experiments and data |
| Collaborator Contribution | Experiments |
| Impact | Publication, PMID: 26134028 |
| Start Year | 2014 |
| Description | G/R, Eelco de Koning, gut organoids |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) Publications: PMIDs: 25500886, 24130334 |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25500886, 2413033 |
| Start Year | 2013 |
| Description | G/R, Fredrik Backhed, Germ free/ gut hormones |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Provision of germ free animals / experiments |
| Impact | none as yet |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | Harokopio University |
| Country | Greece |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Holst perfused intestine and pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Experimental ideas and data |
| Collaborator Contribution | Experiments |
| Impact | Publications, PMIDs: 26280129, 24525020, 26483393 |
| Start Year | 2014 |
| Description | G/R, Karolina Skibicka, central GLP-1 |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 25793511 |
| Start Year | 2013 |
| Description | G/R, Kristina Schoonjans, GPBAR1 |
| Organisation | University of Lausanne |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments and ideas |
| Collaborator Contribution | GM mouse model |
| Impact | Publication, PMID: 26280129 |
| Start Year | 2015 |
| Description | G/R, Medimmune proteomics |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We will develop mass spec gut hormone detection |
| Collaborator Contribution | Financial and intellectual |
| Impact | none as yet |
| Start Year | 2015 |
| Description | G/R, Medimmune studentship |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | joint supervision of PhD student |
| Collaborator Contribution | joint supervision of PhD student |
| Impact | too early in the studentship |
| Start Year | 2014 |
| Description | G/R, Novartis RNAseq |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | Providing information, developing new techniques |
| Collaborator Contribution | Development of new techniques |
| Impact | Developed a priliminary technique to isolate RNA from human enteroednocrine cells |
| Start Year | 2012 |
| Description | G/R, Patrik Rorsman, islet studies |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25172946, 24315372, 20519125 |
| Start Year | 2009 |
| Description | G/R, Pedro Herrera, Islet transdifferentiation |
| Organisation | University of Geneva |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experimental contributions |
| Impact | Publication: PMID 25141178 |
| Start Year | 2013 |
| Description | G/R, Peter Spegel, islet studies |
| Organisation | Lund University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 25731850 |
| Start Year | 2015 |
| Description | G/R, Roche TAAR1 |
| Organisation | F. Hoffmann-La Roche AG |
| Country | Global |
| Sector | Private |
| PI Contribution | Experiments |
| Collaborator Contribution | provision of information and research compounds |
| Impact | Publication: PMID 26241122 |
| Start Year | 2013 |
| Description | G/R, Thue Schwartz, enteroendocrine GPCRome |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25453189, 26483393 |
| Start Year | 2010 |
| Description | G/R, Yvan Gosmain, islet studies |
| Organisation | University of Geneva |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 26696123 |
| Start Year | 2014 |
| Description | GIP receptor localisation and function |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We generated a gipr knockin mouse, which has been shipped to Toronto |
| Collaborator Contribution | Analysis of the genetically modified mouse in Toronto |
| Impact | None to date |
| Start Year | 2016 |
| Description | Gastrectomy clinicians |
| Organisation | Addenbrooke's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Physiological studies on humans after gastrectomy plus in vitro analysis of tissue samples |
| Collaborator Contribution | Identification of suitable patients |
| Impact | Publications |
| Start Year | 2015 |
| Description | Generation of organoids from transgenic models |
| Organisation | Royal Netherlands Academy of Arts and Sciences |
| Department | Hubrecht Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We provided tissue from transgenic mouse models |
| Collaborator Contribution | Collaborators will generate organoids for use in their research programme |
| Impact | None to date |
| Start Year | 2016 |
| Description | Heisler. CNS appetite circuitry |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Transgenic mouse models |
| Collaborator Contribution | Data analysis |
| Impact | Publication |
| Start Year | 2019 |
| Description | Holst perfused pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Ideas for experiments |
| Collaborator Contribution | Perfused pancreas to test ideas developed in Cambridge |
| Impact | Publication |
| Start Year | 2015 |
| Description | Human EEC isolation |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | Development of methodology to purify human L-cells |
| Collaborator Contribution | Method development |
| Impact | Methods still under optimisation |
| Start Year | 2011 |
| Description | LGC peptidomics |
| Organisation | LGC Ltd |
| Country | Global |
| Sector | Private |
| PI Contribution | Supporting a BBSRC iCASE studentship |
| Collaborator Contribution | Analysis and training |
| Impact | One publication to date |
| Start Year | 2017 |
| Description | Larraufie Paris lab |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Experimentation |
| Collaborator Contribution | Experimentation and project planning |
| Impact | Publications |
| Start Year | 2016 |
| Description | Lilly GIPR |
| Organisation | Eli Lilly & Company Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Research in the field of central GIPR signalling |
| Collaborator Contribution | Tool compounds and unpublished data |
| Impact | None yet |
| Start Year | 2018 |
| Description | MedImmune PhD studentship GLP1R |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Joint PhD student with supervisors at Medimmune generating and characterising GLP1R antibodies |
| Collaborator Contribution | MedImmune will provide training and tools |
| Impact | One publication to date |
| Start Year | 2014 |
| Description | Medimmune BBSRC iCASE (Galvin) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Supervision of PhD student |
| Collaborator Contribution | Joint supervision of student, training, peptide synthesis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Mercodia assay validation |
| Organisation | Mercodia AB |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Mass spec analysis to validate Mercodia's glucagon assay. Measurement of patient samples using glucagon and glicentin assays to establish the cause of assay cross reactivity |
| Collaborator Contribution | Provision of assays and suggestions for protocol changes to remove cross-reactivity |
| Impact | Mercodia published a white paper outlining the collaboration and how it has impacted on the use of the glucagon assay |
| Start Year | 2018 |
| Description | Moffett. Trophoblast physiology |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of LC-MS/MS peptidomics to analysis of trophoblast organoids |
| Collaborator Contribution | Development of trophoblast organoids |
| Impact | Publication |
| Start Year | 2018 |
| Description | Pancreatic islet studies |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mouse models, technical and practical assistance with FACS sorting, qRT-PCR analysis |
| Collaborator Contribution | Initiated project and produced samples for analysis |
| Impact | Published manuscripts |
| Start Year | 2010 |
| Description | Rinaman, Fadool, Williams. Central GLP-1 signalling |
| Organisation | Florida State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mouse models |
| Collaborator Contribution | Dissection of CNS appetite circuitry |
| Impact | multiple publications |
| Start Year | 2013 |
| Description | Shin Lee, ETH Zurich |
| Organisation | ETH Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mice |
| Collaborator Contribution | Analysis of transgenic mice |
| Impact | None to date |
| Start Year | 2016 |
| Description | Takeda collaboration |
| Organisation | Takeda Cambridge Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have initiated 2 projects that have been pursued in collaboration with Takeda |
| Collaborator Contribution | Takeda have knockout mouse models that have been given to the project, and researchers at Takeda have carried out in vivo mouse phenotyping that has contributed to the final output. |
| Impact | PMIDs: 25028498 22190648 |
| Start Year | 2009 |
| Description | Ulster, transgenic mice |
| Organisation | Ulster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration involving transgenic mouse models generated in Cambridge, and shipped to Ulster |
| Collaborator Contribution | Collaborators will work with the transgenic model |
| Impact | None to date |
| Start Year | 2016 |
| Description | Valverde. PTP1B in GLP-1 secretion |
| Organisation | Autonomous University of Madrid |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Hosted visiting student and provided training |
| Collaborator Contribution | Visiting student brought project |
| Impact | Publication |
| Start Year | 2017 |
| Description | Yuki Oka |
| Organisation | California Institute of Technology |
| Department | Division of Biology and Biological Engineering (BBE) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of mouse models |
| Collaborator Contribution | Research contribution |
| Impact | Nature publication |
| Start Year | 2017 |
| Description | indole as a signalling molecule from gut microbiota |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A visiting scientist from the department of physics joined our lab part time for 6 months to investigate the physiological role of indole. We provided training, techniques and resources |
| Collaborator Contribution | Our partner provided the salary of the visiting post-doc, and intellectual support |
| Impact | A manuscript is in press |
| Start Year | 2013 |
| Title | GIP-Cre |
| Description | GIP-Cre genetically modified mouse model |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | MTAs in place for sharing with academic collaborators |
| Title | GLP1R-Cre |
| Description | Transgenic mice expressing Cre-recombinase driven by the GLP-1 receptor promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | None known to date |
| Title | GLU-Cre mice |
| Description | Transgenic mice expressing cre-recombinase driven by the proglucagon promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | No known impact to date |
| Title | GLU-CreERT2 |
| Description | Transgenic mice expressing tamoxifen-inducible cre-recombinase driven by the proglucagon promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | None known to date |
| Description | 13th annual Biomarkers Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | An industrial congress bringing together a variety of industrial technologies for the measurement of biomarkers |
| Year(s) Of Engagement Activity | 2018 |
| Description | ADA poster 2014 (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting questions |
| Year(s) Of Engagement Activity | 2014 |
| Description | AEA ADA talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Alice Adriaenssens ADA 2021: invited talk for 'New turf for the other incretin' Diabetes journal symposium Follow up = invitation to contribute opinion piece in Diabetes, Feature article in 'ADA Meeting News' |
| Year(s) Of Engagement Activity | 2021 |
| Description | AEA SSIB talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | SSIB 2021: accepted talk Follow up = won Harry Kissileff prize for best talk, invitation to contribute to Appetite journal |
| Year(s) Of Engagement Activity | 2021 |
| Description | AEA. Oral presentation at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research talk at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation at BSN Neuroendocrinology Celebrate Symposium for ECRs; Glasgow, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at BSN Neuroendocrinology Celebrate Symposium for Early Career Researchers; Glasgow, UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation at Experimental Biology conference; Orlando, US. 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Experimental Biology conference; Orlando, US. Networking |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation to Eli Lilly; Indianapolis, US, 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Research presentation to Eli Lilly. |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Poster at EASD Incretin Study Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | AEA Poster at Incretin Study Group "The role of glucose-dependent insulinotropic polypeptide receptor-expressing neurons in the hypothalamus" |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Poster at NovoNordisk Foundation Metabolism in Action conference; Copenhagen, Denmark 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation at Novonordisk Foundation Metabolism in Action conference; Copenhagen, Denmark. Sparked debate. |
| Year(s) Of Engagement Activity | 2019 |
| Description | BBC Radio Cambridgeshire Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with BBC Radio Cambridgeshire, to discuss gut brain signalling, and the upcoming public lecture at the Science Festival |
| Year(s) Of Engagement Activity | 2017 |
| Description | BBSRC symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | RF poster: Mass spectrometry vs immunoassay SG poster: Identification and in vivo characterisation of novel gut-derived peptides |
| Year(s) Of Engagement Activity | 2020 |
| Description | Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Big Biology Day - engagement activities explaining metabolic research to families |
| Year(s) Of Engagement Activity | 2017 |
| Description | CAS. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | CAS. Poster at EASD incretin study group: "Tracking the development and release of hormone-containing vesicles in murine L-cells" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge AD HE+ Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | lecture by RF |
| Year(s) Of Engagement Activity | 2020 |
| Description | Cambridge Big Weekend |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | hands on events loosley based on the Units research |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cambridge City Council holiday club EM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Science activities at Cambridge City Council drop-in holiday club for families |
| Year(s) Of Engagement Activity | 2021 |
| Description | Cambridge Network recruitment event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay presented at the Cambridge Network recruitment event: "Proglucagon peptide analysis in post gastrectomy patients - bioanalysis or gut feeling?" to people interested in science jobs in the Cambridge area. (asked to present by Mike Van Der Merwe at LGC) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Science Festival - Right Diet debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Audience reported change in views, opinions or behaviours |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.sciencefestival.cam.ac.uk/events/there-right-diet-me |
| Description | Cambridge Science Festival - family activities |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Drop-in hands-on event for families and children. Sparked questions from children and parents |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | Cambridge Science Festival 2014 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands on activity for children sparked discussions with children and parents Very positive feedback from public |
| Year(s) Of Engagement Activity | 2014 |
| Description | Cambridge Science Festival Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public Lecture: Gribble and Fletcher. "Inside out: how the gut changes the brain's view of the world". Followed by questions from the public |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge Science festival, family weekends |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | promoted interest in science taking place at the inst |
| Year(s) Of Engagement Activity | 2013,2014,2015 |
| Description | Cambridgeshire Girlguiding Girls in STEM event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Cambridgeshire Girlguiding Girls in STEM event |
| Year(s) Of Engagement Activity | 2020 |
| Description | Careers day at Presdales Secondary School (Cheryl Brighton) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Speed-dating job careers advise sparked interesting and stimulating discussions. Some pupils expressed interest in a career in Science - to early to judge longterm impact. |
| Year(s) Of Engagement Activity | 2014 |
| Description | DG Poster at EASD study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Developing 2D organoid cultures to study intracellular signalling in enteroendocrine cells" |
| Year(s) Of Engagement Activity | 2017 |
| Description | DG Poster at EASD study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DG. Poster at Incretin Study Group: "Modelling human enteroendocrine cells using adult intestinal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | DG. Poster at Copenhagen Biosciences Conference on Intestinal Organoids 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Modelling hormone secretion in human enteroendocrine cells using adult intestinal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diabetes UK Aug 2014 (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Discussed new treatments for diabetes and their benefits and limitations Patients expressed interest that we are performing research that might improve future therapies |
| Year(s) Of Engagement Activity | 2014 |
| Description | Diabetes UK July 2014 Huntingdon group (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Many questions answered about diabetes treatments Patients better informed about diabetes treatments |
| Year(s) Of Engagement Activity | 2014 |
| Description | EASD poster 2013 (AEA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interesting discussions around data presented on poster Interesting discussion and future collaborations discussed |
| Year(s) Of Engagement Activity | 2013 |
| Description | EASD poster 2013 (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | EASD poster 2014 (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting discussion and collaboration Triggered interesting discussion |
| Year(s) Of Engagement Activity | 2014 |
| Description | EB. Poster at Academic Foundation Programme and NIHR BRC and BTRU Trainee's Annual Research Day 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Localisation and characterisation of glucose-dependent insulinotropic polypeptide receptor (GIPR) expressing cells" |
| Year(s) Of Engagement Activity | 2018 |
| Description | EB. Poster at EASD annual professional meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "GLP1R antibody development and characterisation" |
| Year(s) Of Engagement Activity | 2017 |
| Description | EB. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Development of a GLP-1R antagonistic antibody" |
| Year(s) Of Engagement Activity | 2017 |
| Description | EM Talk at Society for Endocrinology conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk at Society for Endocrinology conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | EM. Poster at Copenhagen Bioscience Conference on Intestinal Organoids 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM Poster. "Using human duodenal organoids to study motilin production and secretion" |
| Year(s) Of Engagement Activity | 2019 |
| Description | EM. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM. Poster at EASD incretin study group. "The contribution of TRP channels to L-cell signalling" |
| Year(s) Of Engagement Activity | 2019 |
| Description | EM: Danish Diabetes Academy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Poster presentation at Danish Diabetes academy - "Characterising stimulus-secretion coupling of the gut hormone motilin in human duodenal organoids" |
| Year(s) Of Engagement Activity | 2020 |
| Description | EM: Physiology of Obesity: From Mechanisms to Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Hormonal Regulation of Gut and Pancreas Physiology" - online webinar as part of Journal of Physiology 'Physiology of Obesity: From Mechanisms to Medicine' series |
| Year(s) Of Engagement Activity | 2020 |
| Description | EM: Virtual Q&A at the Cambridge Rare Disease Network RAREfest 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Virtual Q&A at the Cambridge Rare Disease Network RAREfest 2020 |
| Year(s) Of Engagement Activity | 2020 |
| Description | FG Foster talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | FG gave invited lecture in the Department of Physiology, Development and Neuroscience at University of Cambridge. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FG talk at MRC-DTP symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | FG gave invited lecture at the annual symposium of the MRC-DTP students in Cambridge. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FG talk at Milner Therapeutics Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | FG gave invited lecture to the Milner Institute, which includes industrial audiences from around the world. The talk triggered many interesting questions. |
| Year(s) Of Engagement Activity | 2021 |
| Description | FG, BBC Horizon Special - Right Diet for You |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 3-part BBC2 horizon series |
| Year(s) Of Engagement Activity | 2015 |
| Description | FG, BBC Radio 4 programme, Inside Health |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 'Discussion of publication: "Diagnosis of gestational diabetes: falling through the net" |
| Year(s) Of Engagement Activity | 2015 |
| Description | FG, Press release, article covered by BBC News and multiple international medical publications |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | 'Discussion of publication: "Diagnosis of gestational diabetes: falling through the net" |
| Year(s) Of Engagement Activity | 2015 |
| Description | FR SSIB annual meeting 2019 - poster presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | SSIB annual meeting 09-13Jul2019 (poster): "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR oral presentation at EASD annual meeting 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | oral presentation "GLP-1 secreting enteroendocrine cells co-release ATP to modulate vagal afferent neuronal activity" delivered on 05Oct2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | FR oral presentation at Wellcome Trust meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wellcome Meeting at Sanger 31Jan-01Feb2019 (oral): "A role of hypothalamic glucose-dependent insulinotropic polypeptide receptor (GIPR) in feeding behaviour" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR. Poster at EASD incretin study group. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FR poster at EASD study group: "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR. presentation at Danish Diabetes Academy Winter School for postdoctoral researchers, at Higuerõn Hotel in Malaga/Spain 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Incretins along the gut-pancreas-brain axis". |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR: Mercodia Diagnostics, Uppsala. Invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited to talk to Mercodia about how our mass spec analysis methods complement their immunoassay development |
| Year(s) Of Engagement Activity | 2019 |
| Description | Familial Gastric Cancer Study Day (Geoff Roberts) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | 80-100 participants and family members, with familial gastric cancer, attended a study day to learn more about current research and practice. Geoff Roberts was one of the invited speakers. A number of patients expressed an interest in participating in our future research |
| Year(s) Of Engagement Activity | 2016 |
| Description | GPR. Cambridge UGI cancer symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | "The post-gastrectomy patient, metabolic considerations" |
| Year(s) Of Engagement Activity | 2018 |
| Description | GPR. Talk at EASD incretin study group meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Total Gastrectomy with Roux-en-Y reconstruction results in significant changes in gut hormone and glucose homeostasis" |
| Year(s) Of Engagement Activity | 2017 |
| Description | IMS online academy EM CAS OW |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | developed work experience programme for ~12 Y10 students from underrepresented schools in Cambridge |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited seminar at Genomics Institute of Novartis Research Foundation (FMG) 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion about Novartis' drug development program The researchers at Novartis used my expertise to help in their ongoing drug development program targeting intestinal enteroendocrine cells |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited seminar at Technische Universität München (FMG) 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Sparked discussion and potential collaboration |
| Year(s) Of Engagement Activity | 2013 |
| Description | Invited seminar at UCL (FMG) 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered discussion and further experiments that we tried together Further joint experiments following discussions on the day |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited talk at Paris Descartes (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | The speaker, P.Richards, was offered a research position on the basis of this talk Career progression for P.Richards |
| Year(s) Of Engagement Activity | 2014 |
| Description | JL Choosing your first postdoc. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Lewis JE and Joanisse D (2021) Choosing your first postdoc. Career Progression Workshop, Future Physiology, online. |
| Year(s) Of Engagement Activity | 2021 |
| Description | JL Oral presentation at BSN/SFE, online |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lewis JE, Woodward ORM, Phillips BU, Tripodi M, Hornigold D, Baker D, Gribble FM, Reimann F (2021) Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice. |
| Year(s) Of Engagement Activity | 2021 |
| Description | JL. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | JL. Poster at EASD study group. "RXFP4, the cognate receptor for insulin-like peptide 5, alters food preference in mice" |
| Year(s) Of Engagement Activity | 2019 |
| Description | JL: Webinar series for Physiological Society |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The series sort to highlight work by early career researchers to negate some of the negative aspects of covid/lockdown. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=ysOgs96WXEU&list=PLlqI96GMwNGHBi3vx5On-aS5HeZvTupuy&index=12 |
| Description | LB. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Synergistic effects of concomitant activation of FFAR1 and GPBAR-1 on L-cell calcium and secretory responses" |
| Year(s) Of Engagement Activity | 2017 |
| Description | MRC Centenary Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A hands-on practical demonstration, devised and manned by researchers from our group. The practical was based on sweet taste perception and targeted at members of the public. Engaged participation and interesting discussions with the public Well received from feedback |
| Year(s) Of Engagement Activity | 2013 |
| Description | MRL Science Slam |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The presenters (a post doc and student together) won a prize for their presentation |
| Year(s) Of Engagement Activity | 2018 |
| Description | MY Poster at Incretin Study Group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Characterisation of Electrical Activity in STC-1 Cells and their relevance to study Voltage-gated Ion Channels in Primary K- and L-cells |
| Year(s) Of Engagement Activity | 2017 |
| Description | MY Poster at Incretin Study Group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | MY poster at Incretin Study Group: "Amino acid sensing in K and L cells from mouse duodenal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | MY. Oral presentation at Diabetes UK Annual Professional Conference 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Metformin alters glucose uptake and metabolism in intestinal cells |
| Year(s) Of Engagement Activity | 2019 |
| Description | OW STEM for BRITAIN |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | STEM for BRITAIN is a major scientific poster competition and exhibition which has been held in Parliament since 1997, and is organised by the Parliamentary & Scientific Committee. Its aim is to give members of both Houses of Parliament an insight into the outstanding research work being undertaken in UK universities by early-career researchers. Prizes are awarded for the posters presented in each discipline which best communicated high level science, engineering or mathematics to a lay audience. The audience was made up of MPs, senior scientists, industry representatives and early career researchers. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://stemforbritain.org.uk/ |
| Description | OW. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | OW poster at EASD incretin study group: "Distribution of G protein coupled relaxin/insulin-like family peptide receptor-4 (RXFP4) expressing cells in the mouse brain" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Oxfordshire Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Audience reported change in views, opinions or behaviours |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.sciencefestival.cam.ac.uk/events/there-right-diet-me |
| Description | PL. Poster at Incretin Study Group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "SCFAs increase PYY but not GLP1 production in human L-cells " |
| Year(s) Of Engagement Activity | 2017 |
| Description | PL. Talk at Incretin Study Group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | PL. Talk at Incretin Study Group. "Peptidomics to study enteroendocrine cells after bariatric surgery" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation to local Brownies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | RF: Girls in STEM "Why I'm a scientist" |
| Year(s) Of Engagement Activity | 2020 |
| Description | Professional PhD Networking forum AgroParistech and ABIES doctoral school Doc'Avenir |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Pierre Larraufie: Professional PhD Networking forum AgroParistech and ABIES doctoral school Doc'Avenir, 2017, Round table invited speaker about positions and career after a PhD. |
| Year(s) Of Engagement Activity | 2017 |
| Description | REF Poster at SymBLS 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at DMDG open meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | "Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients" |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | REF poster at EASD study group "A multiplex method for quantifying gut hormone peptides using Mass Spectrometry" |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at REID Bioanalytical Forum 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Immunoassay vs Mass Spectrometry -Measuring insulin and insulin analogues in human plasma |
| Year(s) Of Engagement Activity | 2019 |
| Description | RF: Murray Edwards Graduate Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | RF: Measuring insulin and insulin analogues in human plasma |
| Year(s) Of Engagement Activity | 2021 |
| Description | RGK Proteomics Method Forum 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Peptidomics: bridging the space between large and small molecule mass spectrometry |
| Year(s) Of Engagement Activity | 2020 |
| Description | RGK. American Society for Mass Spectrometry (ASMS) 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Waters user group meeting, presentation: "LC-MS analysis of plasma from patients with insulin autoimmune syndrome" Waters MS focused user meeting (Pharmaceutical track) Outcome: Video of talk available on Waters website, video interview on Select Science website, as well as an in-lab video interview. |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Development of a rapid extraction method for the analysis of gut peptide hormones by LC-MS/MS" |
| Year(s) Of Engagement Activity | 2017 |
| Description | RGK. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster at EASD incretin study group: "Proglucagon peptide analysis - will the real peptide please stand up!" |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Reid Bioanalytical Forum 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | "LC-MS analysis of plasma from patients with insulin autoimmune syndrome" Meeting focussing on broad bioanalytical approaches for wide range of analytes Outcome: Video interview by Bionalaysis zone, available on their website |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Waters UK and Ireland Clinical User Meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Waters UK and Ireland Clinical User Meeting 2019 "LCMS Analysis of Proinsulin Derived Peptides" Waters meeting for users of MS systems in clinical environments |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK: Select Science Clinical Science Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plasma peptidomics - an untapped resource for biomarker analysis." |
| Year(s) Of Engagement Activity | 2020 |
| Description | SG. Poster at EASD incretin study group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | SG. Poster at EASD study group. "Characterisation of novel gut-derived peptides in vivo and in vitro" |
| Year(s) Of Engagement Activity | 2019 |
| Description | SG. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | LC-MS based detection of insulin-like peptide 5 in primary colonic cultures |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit (CM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A practical demonstration and associated discussion of the gut, presented by 2 of our PhD students to pupils at a local school. Good feedback |
| Year(s) Of Engagement Activity | 2013 |
| Description | Science lesson at primary school (CLM) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Triggered interesting discussions Greater interest in science and medicine |
| Year(s) Of Engagement Activity | 2012 |
| Description | Seminar at University of Sheffield (FMG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interesting discussion and plans for future collaboration The Sheffield group have employed one of our previous summer students to do a PhD, and we plan to work together on gut hormone effects on intestinal afferent nerves |
| Year(s) Of Engagement Activity | 2014 |
| Description | Stimulating innovation, experiences working with industry (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Stimulated discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | Suffolk Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Suffolk Science Festival |
| Year(s) Of Engagement Activity | 2020 |
| Description | Summer school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Alison Douglas Summer School, for ~30 early career researchers from around Europe. I led an interactive morning session on gut hormones. Very positive feedback received (scored as best presentation from feedback forms) |
| Year(s) Of Engagement Activity | 2013 |
| Description | Sustainable Future Acacemy |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Online event |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.cam.ac.uk/public-engagement/information-for-staff-and-students/the-sustainable-futures-a... |
| Description | TD. Poster at EASD study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | TD. Poster at EASD incretin study group. "Neutral amino acid transporter: SLC6a19- linking amino acid sensing to gut hormone secretion?" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay was Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course. A three day course held at Loughborough University, focussed on the dissemination of knowledge for developing bioanalytical methodologies for large molecule analytes. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay was Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course. A three day course held at Loughborough University, focussed on the dissemination of knowledge for developing bioanalytical methodologies for large molecule analytes. |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of Cambridge & AZ science symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | SG Presentation: Utilising LC/MS to identify novel bioactive gut-derived peptides and peptidomic differences in type 2 diabetic human islets FG Panel discussion |
| Year(s) Of Engagement Activity | 2020 |
| Description | VBL talk at Incretin 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | VBL talk at EASD Incretin Study group, "Adenosine triphosphate (ATP) is released from glucagon-like peptide 1 (GLP-1) secreting cells and signals to vagal afferent neurons" |
| Year(s) Of Engagement Activity | 2019 |
| Description | VBL. Poster at Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | VBL presented a poster at a local Cambridge Neuroscience Association meeting at Robinson College on March 14th, 2019. It was called "Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience" and the poster title was "ATP is released from GLP-1 secreting enteroendocrine cells and signals to vagal afferent neruones". It was a valuable experience sharing our work on gut-brain signalling to the larger Cambridge neuroscience community. |
| Year(s) Of Engagement Activity | 2019 |
| Description | WT PhD Studentship meeting (London 2013) (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | poster presentation |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered discussion |
| Year(s) Of Engagement Activity | 2013 |