The Enteroendocrine System in Health and Disease
Lead Research Organisation:
University of Cambridge
Abstract
The aims of our research are to understand how hormones from the gut influence appetite and blood glucose control.
After a meal, the gut produces hormones signalling to the brain to stop eating, and to the pancreas that it is time to release more insulin. One of these gut hormones has recently been developed as a new treatment for diabetes, and many people are interested in whether any other gut hormones could also be developed for the treatment of diabetes and obesity.
Our programme of research aims to understand how gut hormones are released after a meal, and whether it would be possible to alter their production as a new form of treatment. We study how individual hormone-producing cells detect nutrients, using techniques that allow us to monitor how single cells respond to stimuli in real time. By removing specific genes in mice, we can build up a picture of which genes are most important for how these gut cells work. The findings can then be used as a starting point for devising new ways to alter hormone release in humans.
After a meal, the gut produces hormones signalling to the brain to stop eating, and to the pancreas that it is time to release more insulin. One of these gut hormones has recently been developed as a new treatment for diabetes, and many people are interested in whether any other gut hormones could also be developed for the treatment of diabetes and obesity.
Our programme of research aims to understand how gut hormones are released after a meal, and whether it would be possible to alter their production as a new form of treatment. We study how individual hormone-producing cells detect nutrients, using techniques that allow us to monitor how single cells respond to stimuli in real time. By removing specific genes in mice, we can build up a picture of which genes are most important for how these gut cells work. The findings can then be used as a starting point for devising new ways to alter hormone release in humans.
Technical Summary
This programme addresses enteroendocrine cell physiology, identifying strategies to enhance secretion of gut hormones that regulate appetite and insulin release.
The gut endocrine system is increasingly recognised as a central player in the coordination of appetite, insulin release and post-prandial nutrient homeostasis. It likely underlies many of the beneficial physiological responses to gastric bypass surgery, and some of the secreted hormones have already been harnessed successfully for the treatment of diabetes and short bowel syndrome. Emerging therapies based on the secretion and action of gut peptides are predicted to be major players in the future treatment of metabolic disease.
Understanding the physiology of the gut endocrine system is critical for identifying novel strategies to modulate hormone release in humans and interpreting post-ingestive and post-bypass physiology. This is an area of research that has advanced dramatically in the past decade, with the introduction of technologies to identify, isolate and interrogate enteroendocrine cells in murine models. As a result, some general principles of stimulus detection in incretin-secreting K- and L-cells have now been established, but there are many unanswered questions such as the relative importance of different enteroendocrine signalling pathways in vivo, the functional overlap between different enteroendocrine cell types, and the impact of genetics, diet and metabolic disease on the enteroendocrine system?
These questions will be addressed here using a candidate gene approach. Genes for functional evaluation will be selected based on their predicted effects on whole body physiology, enteroendocrine cell development, nutrient sensing and/or secretion. State-of-the-art optical and electrophysiological recording techniques will be utilised to monitor dynamic physiological responses of single identified enteroendocrine cells in primary culture, and the intact gut-brain-pancreatic axis will be assessed in vivo using genetically modified mouse models. Promising enteroendocrine target receptors and pathways will be further evaluated for translational effects on appetite and glucose homeostasis in humans.
The gut endocrine system is increasingly recognised as a central player in the coordination of appetite, insulin release and post-prandial nutrient homeostasis. It likely underlies many of the beneficial physiological responses to gastric bypass surgery, and some of the secreted hormones have already been harnessed successfully for the treatment of diabetes and short bowel syndrome. Emerging therapies based on the secretion and action of gut peptides are predicted to be major players in the future treatment of metabolic disease.
Understanding the physiology of the gut endocrine system is critical for identifying novel strategies to modulate hormone release in humans and interpreting post-ingestive and post-bypass physiology. This is an area of research that has advanced dramatically in the past decade, with the introduction of technologies to identify, isolate and interrogate enteroendocrine cells in murine models. As a result, some general principles of stimulus detection in incretin-secreting K- and L-cells have now been established, but there are many unanswered questions such as the relative importance of different enteroendocrine signalling pathways in vivo, the functional overlap between different enteroendocrine cell types, and the impact of genetics, diet and metabolic disease on the enteroendocrine system?
These questions will be addressed here using a candidate gene approach. Genes for functional evaluation will be selected based on their predicted effects on whole body physiology, enteroendocrine cell development, nutrient sensing and/or secretion. State-of-the-art optical and electrophysiological recording techniques will be utilised to monitor dynamic physiological responses of single identified enteroendocrine cells in primary culture, and the intact gut-brain-pancreatic axis will be assessed in vivo using genetically modified mouse models. Promising enteroendocrine target receptors and pathways will be further evaluated for translational effects on appetite and glucose homeostasis in humans.
Organisations
- University of Cambridge, United Kingdom (Collaboration, Lead Research Organisation)
- University of Gothenburg, Sweden (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Mayo Clinic (Collaboration)
- Utrecht University (Collaboration)
- Lausanne University, Switzerland (Collaboration)
- Royal Netherlands Academy of Arts and Sciences (Collaboration)
- Wageningen University & Research (Collaboration)
- University of Toronto (Collaboration)
- Novartis (Collaboration)
- Swiss Federal Institute of Technology (ETH), Zurich (Collaboration)
- F. Hoffmann-La Roche AG (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- Ulster University (Collaboration)
- Eli Lilly & Company Ltd (Collaboration)
- LGC Limited, United Kingdom (Collaboration)
- Danone (Collaboration)
- Harokopio University (Collaboration)
- Maastricht University (UM) (Collaboration)
- University of Lille (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- University Medical Centre Utrecht, Netherlands (Collaboration)
- Mercodia AB (Collaboration)
- Medical Research Council (Collaboration)
- University of Geneva, Switzerland (Collaboration)
- Autonomous University of Madrid, Spain (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- University of Copenhagen, Denmark (Collaboration)
- University of Aberdeen, United Kingdom (Collaboration)
- California Institute of Technology, United States (Collaboration)
- Takeda Cambridge Ltd (Collaboration)
- University of Cologne, Germany (Collaboration)
- Florida State University, United States (Collaboration)
- Lund University (Collaboration)
- Encap Drug Delivery (Collaboration)
- MedImmune (Collaboration)
- Addenbrooke's Hospital (Collaboration)
Publications
Adriaenssens A
(2015)
A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.
in Endocrinology
Adriaenssens AE
(2020)
The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system.
in Peptides
Adriaenssens AE
(2016)
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.
in Diabetologia
Adriaenssens AE
(2018)
Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract.
in Comprehensive Physiology
Adriaenssens AE
(2019)
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
in Cell metabolism
Anesten F
(2016)
Preproglucagon neurons in the hindbrain have IL-6 receptor-a and show Ca2+ influx in response to IL-6.
in American journal of physiology. Regulatory, integrative and comparative physiology
Arora T
(2018)
Microbial regulation of the L cell transcriptome.
in Scientific reports
Ast J
(2020)
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
in Nature communications
Augustine V
(2018)
Hierarchical neural architecture underlying thirst regulation.
in Nature
| Description | JDRF UK Beta Cell Renewal Roundtable |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | MRC Workshop on Neuroscience of Obesity: Gut-brain communication |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Description | Addenbrooke's Charitable Trust Fellowship (Geoff Roberts) |
| Amount | £52,000 (GBP) |
| Organisation | Addenbrooke's Charitable Trust (ACT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2017 |
| Description | BBSRC DTP PhD studentship (Ming Yang) |
| Amount | £95,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2019 |
| Description | BBSRC FTMA to Juraj Rievaj |
| Amount | £14,656 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 07/2018 |
| Description | BBSRC iCASE |
| Amount | £105,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | BBSRC iCASE |
| Amount | £145,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | BBSRC iCASE studentship partnered with MedImmune (Sam Galvin) |
| Amount | £95,196 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2020 |
| Description | Bakala Foundation Scholarship (Cristian Riccio) |
| Amount | £15,000 (GBP) |
| Organisation | Zdenek and Michaela Bakala foundation |
| Sector | Charity/Non Profit |
| Country | Switzerland |
| Start | 08/2014 |
| End | 07/2015 |
| Description | British Society for Neuroendocrinology small grant (Juraj Rievaj) |
| Amount | £3,500 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 06/2017 |
| Description | DAAD-PROMOS-Stipend for Ms Friederike Uhlig |
| Amount | € 1,725 (EUR) |
| Organisation | University of Hohenheim |
| Sector | Academic/University |
| Country | Germany |
| Start | 09/2013 |
| End | 12/2013 |
| Description | EASD travel grant |
| Amount | € 300 (EUR) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 10/2018 |
| End | 10/2018 |
| Description | EFSD |
| Amount | € 122,000 (EUR) |
| Funding ID | rg89241 |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Academic/University |
| Country | Germany |
| Start | 06/2017 |
| End | 11/2018 |
| Description | EFSD/Boehringer Ingelheim Programme |
| Amount | € 100,000 (EUR) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Academic/University |
| Country | Germany |
| Start | 08/2014 |
| End | 07/2016 |
| Description | EMBO Short Term Fellowship (Catalin Chimerel) |
| Amount | € 7,500 (EUR) |
| Organisation | European Molecular Biology Organisation |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 09/2016 |
| End | 12/2016 |
| Description | ESE St Odile meeting grant |
| Amount | € 450 (EUR) |
| Organisation | European Society of Endocrinology |
| Sector | Learned Society |
| Country | European Union (EU) |
| Start | 10/2018 |
| End | 10/2018 |
| Description | Early career grant to Juraj Rievaj |
| Amount | £8,588 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 06/2018 |
| Description | Early career grant to Van Lu |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 07/2018 |
| Description | G/R, Joint Wellcome Trust Senior Investigators |
| Amount | £1,900,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 06/2020 |
| Description | Jo Lewis, BSN symposium support for Physiology 2019, Aberdeen, UK |
| Amount | £2,000 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2019 |
| Description | Jo Lewis, BSN symposium support for the ECR day at the BSN's annual conference, Glasgow, UK |
| Amount | £5,000 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2019 |
| Description | Jo Lewis, The Physiological Society satellite support for Physiology 2019, Aberdeen, UK |
| Amount | £20,000 (GBP) |
| Organisation | Physiological Society |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 08/2019 |
| End | 08/2019 |
| Description | Jo Lewis, The Physiological Society symposium support for Experimental Biology, Orlando, |
| Amount | £2,000 (GBP) |
| Organisation | Physiological Society |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 06/2019 |
| End | 06/2019 |
| Description | Lister Summer Studentship |
| Amount | £1,600 (GBP) |
| Organisation | Lister Institute of Preventive Medicine |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2013 |
| End | 08/2013 |
| Description | MedImmune PhD studentship programme |
| Amount | £96,074 (GBP) |
| Organisation | MedImmune |
| Sector | Private |
| Country | United States |
| Start | 10/2014 |
| End | 09/2018 |
| Description | Medimmune grant |
| Amount | £272,857 (GBP) |
| Organisation | MedImmune |
| Sector | Private |
| Country | United States |
| Start | 06/2015 |
| End | 08/2017 |
| Description | Project Support Grant to Juraj Rievaj |
| Amount | £3,680 (GBP) |
| Organisation | British Society for Neuroendocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2018 |
| Description | Royal College of Surgeons Research Fellowship |
| Amount | £20,000 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2018 |
| Description | Society for Endocrinology Early Career Grant (Arianna Psichas) |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2016 |
| Description | Society for Endocrinology Early Career Grant (Catalin Chimerel) |
| Amount | £9,924 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 05/2017 |
| Description | Wellcome PhD studentship to Elisabeth O'Flaherty |
| Amount | £180,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2022 |
| Description | Wellcome PhD studentship to Emily Miedzybrodzka |
| Amount | £180,824 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2021 |
| Title | G/R, Measurement of GLP-1 from epithelial sheets |
| Description | Optimising the use of Ussing chambers technology for the reliable measurement of basolateral GLP-1 secretion from epithelial sheets |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Method allowed to distinguish between apical and basolateral effect of various drugs on GLP-1 secretion (Brighton et al, 2015) |
| URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606749/ |
| Title | GIP-Venus transgenic mouse |
| Description | Venus driven by the GIP promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Shared with some other groups and licensed |
| Title | GLU-Cre transgenic mouse |
| Description | Cre-recombinase driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | Shared with other groups and licensed to industry |
| Title | GLU-Venus transgenic mouse |
| Description | Fluorescent protein driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | Shared with many collaborators around the world and licensed to industry |
| Title | Gipr-Cre transgenic mouse |
| Description | GIPR-Cre mouse enabling identification and manipulation of cells expressing Gipr |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Collaborations and publications. Research collaboration with Eli Lilly, investigating MOA of GLP1/GIP dual agonists (currently in phase 3 clinical trials) |
| Title | Glu-CreERT2 |
| Description | Tamoxifen-inducible cre expression driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Shared with academic collaborators and licensed to industry |
| Title | Glu-Epac2camps transgenic mouse |
| Description | transgenic mice in which the cAMP FRET sensor Epac2camps is driven by the proglucagon promoter |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Shared with collaborators |
| Title | Guanylin-Venus transgenic mouse |
| Description | Guanylin-venus mouse, enabling identification and characterisation of cells expressing guanylin |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Publication |
| Title | Insl5-rtTA mouse |
| Description | transgenic mouse Insl5-rtTA allowing identification and manipulation of INSL5-expressing cells |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | publications |
| Title | Rxfp4-Cre transgenic mouse |
| Description | Rxfp4-Cre transgenic mouse |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2015 |
| Provided To Others? | No |
| Impact | BBSRC-iCASE studentship joint with AstraZeneca to investigate central signalling involving Rxfp4 |
| Title | sst-cre transgenic mouse |
| Description | Cre-recombinase driven by the somatostatin promoter in a transgenic mouse model |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Shared with academic collaborators |
| Description | Acosta |
| Organisation | Mayo Clinic |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Training provided to Acosta's group |
| Collaborator Contribution | Analysis of patient samples |
| Impact | None |
| Start Year | 2018 |
| Description | Brubaker lab |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Mouse models and discussion |
| Collaborator Contribution | Experimentation and project design |
| Impact | Publication |
| Start Year | 2015 |
| Description | FG, Susan Jebb, HNR |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Nutrition Research Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Assays and discussion |
| Collaborator Contribution | Ran project |
| Impact | Publication, PMID: 26054049 |
| Start Year | 2014 |
| Description | Full4Health |
| Organisation | Danone |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Encap Drug Delivery |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Harokopio University |
| Country | Greece |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Maastricht University (UM) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Norwegian University of Science and Technology (NTNU) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University Medical Center Utrecht (UMC) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Cologne |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | Full4Health |
| Organisation | Wageningen University & Research |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We run 2 workpackages in this consortium. One is a basic science programme and the other a translational programme. |
| Collaborator Contribution | The overall consortium brings funding to our lab, and Encap are manufacturing clinical grade capsules for our translational study. The University of Copenhagen have sent post-graduate students to our lab for a few months to establish collaborations and learn new techniques. Blood samples collected by other partners will be analysed here in Cambridge for metabolic parameters and gut hormones. |
| Impact | Meetings Summer school Publications Collaborations |
| Start Year | 2011 |
| Description | G/R Bertie Goettgens, Single Cell RNAseq |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments |
| Collaborator Contribution | Experiments |
| Impact | none yet |
| Start Year | 2015 |
| Description | G/R, Bart Staels, FXR |
| Organisation | University of Lille |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Experiments and data |
| Collaborator Contribution | Experiments |
| Impact | Publication, PMID: 26134028 |
| Start Year | 2014 |
| Description | G/R, Eelco de Koning, gut organoids |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) Publications: PMIDs: 25500886, 24130334 |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25500886, 2413033 |
| Start Year | 2013 |
| Description | G/R, Fredrik Backhed, Germ free/ gut hormones |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Provision of germ free animals / experiments |
| Impact | none as yet |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | Harokopio University |
| Country | Greece |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Full4 Health |
| Organisation | Utrecht University |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Supervision of laboratory work done |
| Collaborator Contribution | Provision of samples and payment for consumables |
| Impact | None yet. Multidisciplinary. |
| Start Year | 2015 |
| Description | G/R, Holst perfused intestine and pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Experimental ideas and data |
| Collaborator Contribution | Experiments |
| Impact | Publications, PMIDs: 26280129, 24525020, 26483393 |
| Start Year | 2014 |
| Description | G/R, Karolina Skibicka, central GLP-1 |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 25793511 |
| Start Year | 2013 |
| Description | G/R, Kristina Schoonjans, GPBAR1 |
| Organisation | University of Lausanne |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments and ideas |
| Collaborator Contribution | GM mouse model |
| Impact | Publication, PMID: 26280129 |
| Start Year | 2015 |
| Description | G/R, Medimmune proteomics |
| Organisation | MedImmune |
| Country | United States |
| Sector | Private |
| PI Contribution | We will develop mass spec gut hormone detection |
| Collaborator Contribution | Financial and intellectual |
| Impact | none as yet |
| Start Year | 2015 |
| Description | G/R, Medimmune studentship |
| Organisation | MedImmune |
| Country | United States |
| Sector | Private |
| PI Contribution | joint supervision of PhD student |
| Collaborator Contribution | joint supervision of PhD student |
| Impact | too early in the studentship |
| Start Year | 2014 |
| Description | G/R, Novartis RNAseq |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | Providing information, developing new techniques |
| Collaborator Contribution | Development of new techniques |
| Impact | Developed a priliminary technique to isolate RNA from human enteroednocrine cells |
| Start Year | 2012 |
| Description | G/R, Patrik Rorsman, islet studies |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25172946, 24315372, 20519125 |
| Start Year | 2009 |
| Description | G/R, Pedro Herrera, Islet transdifferentiation |
| Organisation | University of Geneva |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experimental contributions |
| Impact | Publication: PMID 25141178 |
| Start Year | 2013 |
| Description | G/R, Peter Spegel, islet studies |
| Organisation | Lund University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 25731850 |
| Start Year | 2015 |
| Description | G/R, Roche TAAR1 |
| Organisation | F. Hoffmann-La Roche AG |
| Country | Global |
| Sector | Private |
| PI Contribution | Experiments |
| Collaborator Contribution | provision of information and research compounds |
| Impact | Publication: PMID 26241122 |
| Start Year | 2013 |
| Description | G/R, Thue Schwartz, enteroendocrine GPCRome |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publications: PMIDs: 25453189, 26483393 |
| Start Year | 2010 |
| Description | G/R, Yvan Gosmain, islet studies |
| Organisation | University of Geneva |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Experiments/ Provision of Research Tools (mice) |
| Collaborator Contribution | Experiments |
| Impact | Publication: PMID: 26696123 |
| Start Year | 2014 |
| Description | GIP receptor localisation and function |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | We generated a gipr knockin mouse, which has been shipped to Toronto |
| Collaborator Contribution | Analysis of the genetically modified mouse in Toronto |
| Impact | None to date |
| Start Year | 2016 |
| Description | Gastrectomy clinicians |
| Organisation | Addenbrooke's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Physiological studies on humans after gastrectomy plus in vitro analysis of tissue samples |
| Collaborator Contribution | Identification of suitable patients |
| Impact | Publications |
| Start Year | 2015 |
| Description | Generation of organoids from transgenic models |
| Organisation | Royal Netherlands Academy of Arts and Sciences |
| Department | Hubrecht Institute |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We provided tissue from transgenic mouse models |
| Collaborator Contribution | Collaborators will generate organoids for use in their research programme |
| Impact | None to date |
| Start Year | 2016 |
| Description | Heisler. CNS appetite circuitry |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Transgenic mouse models |
| Collaborator Contribution | Data analysis |
| Impact | Publication |
| Start Year | 2019 |
| Description | Holst perfused pancreas |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Ideas for experiments |
| Collaborator Contribution | Perfused pancreas to test ideas developed in Cambridge |
| Impact | Publication |
| Start Year | 2015 |
| Description | Human EEC isolation |
| Organisation | Novartis |
| Country | Global |
| Sector | Private |
| PI Contribution | Development of methodology to purify human L-cells |
| Collaborator Contribution | Method development |
| Impact | Methods still under optimisation |
| Start Year | 2011 |
| Description | LGC peptidomics |
| Organisation | LGC Ltd |
| Country | Global |
| Sector | Private |
| PI Contribution | Supporting a BBSRC iCASE studentship |
| Collaborator Contribution | Analysis and training |
| Impact | One publication to date |
| Start Year | 2017 |
| Description | Larraufie Paris lab |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Experimentation |
| Collaborator Contribution | Experimentation and project planning |
| Impact | Publications |
| Start Year | 2016 |
| Description | Lilly GIPR |
| Organisation | Eli Lilly & Company Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Research in the field of central GIPR signalling |
| Collaborator Contribution | Tool compounds and unpublished data |
| Impact | None yet |
| Start Year | 2018 |
| Description | MedImmune PhD studentship GLP1R |
| Organisation | MedImmune |
| Country | United States |
| Sector | Private |
| PI Contribution | Joint PhD student with supervisors at Medimmune generating and characterising GLP1R antibodies |
| Collaborator Contribution | MedImmune will provide training and tools |
| Impact | One publication to date |
| Start Year | 2014 |
| Description | Medimmune BBSRC iCASE (Galvin) |
| Organisation | MedImmune |
| Department | MedImmune Cambridge |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Supervision of PhD student |
| Collaborator Contribution | Joint supervision of student, training, peptide synthesis |
| Impact | None yet |
| Start Year | 2016 |
| Description | Mercodia assay validation |
| Organisation | Mercodia AB |
| Country | Sweden |
| Sector | Private |
| PI Contribution | Mass spec analysis to validate Mercodia's glucagon assay. Measurement of patient samples using glucagon and glicentin assays to establish the cause of assay cross reactivity |
| Collaborator Contribution | Provision of assays and suggestions for protocol changes to remove cross-reactivity |
| Impact | Mercodia published a white paper outlining the collaboration and how it has impacted on the use of the glucagon assay |
| Start Year | 2018 |
| Description | Moffett. Trophoblast physiology |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Application of LC-MS/MS peptidomics to analysis of trophoblast organoids |
| Collaborator Contribution | Development of trophoblast organoids |
| Impact | Publication |
| Start Year | 2018 |
| Description | Pancreatic islet studies |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mouse models, technical and practical assistance with FACS sorting, qRT-PCR analysis |
| Collaborator Contribution | Initiated project and produced samples for analysis |
| Impact | Published manuscripts |
| Start Year | 2010 |
| Description | Rinaman, Fadool, Williams. Central GLP-1 signalling |
| Organisation | Florida State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mouse models |
| Collaborator Contribution | Dissection of CNS appetite circuitry |
| Impact | multiple publications |
| Start Year | 2013 |
| Description | Shin Lee, ETH Zurich |
| Organisation | ETH Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Provision of transgenic mice |
| Collaborator Contribution | Analysis of transgenic mice |
| Impact | None to date |
| Start Year | 2016 |
| Description | Takeda collaboration |
| Organisation | Takeda Cambridge Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have initiated 2 projects that have been pursued in collaboration with Takeda |
| Collaborator Contribution | Takeda have knockout mouse models that have been given to the project, and researchers at Takeda have carried out in vivo mouse phenotyping that has contributed to the final output. |
| Impact | PMIDs: 25028498 22190648 |
| Start Year | 2009 |
| Description | Ulster, transgenic mice |
| Organisation | Ulster University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration involving transgenic mouse models generated in Cambridge, and shipped to Ulster |
| Collaborator Contribution | Collaborators will work with the transgenic model |
| Impact | None to date |
| Start Year | 2016 |
| Description | Valverde. PTP1B in GLP-1 secretion |
| Organisation | Autonomous University of Madrid |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Hosted visiting student and provided training |
| Collaborator Contribution | Visiting student brought project |
| Impact | Publication |
| Start Year | 2017 |
| Description | Yuki Oka |
| Organisation | California Institute of Technology |
| Department | Division of Biology and Biological Engineering (BBE) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Provision of mouse models |
| Collaborator Contribution | Research contribution |
| Impact | Nature publication |
| Start Year | 2017 |
| Description | indole as a signalling molecule from gut microbiota |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A visiting scientist from the department of physics joined our lab part time for 6 months to investigate the physiological role of indole. We provided training, techniques and resources |
| Collaborator Contribution | Our partner provided the salary of the visiting post-doc, and intellectual support |
| Impact | A manuscript is in press |
| Start Year | 2013 |
| Title | GIP-Cre |
| Description | GIP-Cre genetically modified mouse model |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | |
| Licensed | No |
| Impact | MTAs in place for sharing with academic collaborators |
| Title | GLP1R-Cre |
| Description | Transgenic mice expressing Cre-recombinase driven by the GLP-1 receptor promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | None known to date |
| Title | GLU-Cre mice |
| Description | Transgenic mice expressing cre-recombinase driven by the proglucagon promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | No known impact to date |
| Title | GLU-CreERT2 |
| Description | Transgenic mice expressing tamoxifen-inducible cre-recombinase driven by the proglucagon promoter |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2016 |
| Licensed | Yes |
| Impact | None known to date |
| Description | 13th annual Biomarkers Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | An industrial congress bringing together a variety of industrial technologies for the measurement of biomarkers |
| Year(s) Of Engagement Activity | 2018 |
| Description | ADA poster 2014 (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting questions |
| Year(s) Of Engagement Activity | 2014 |
| Description | AEA. Oral presentation at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research talk at Society for the Study of Ingestive Behaviour conference; Utrecht, Netherlands. |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation at BSN Neuroendocrinology Celebrate Symposium for ECRs; Glasgow, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at BSN Neuroendocrinology Celebrate Symposium for Early Career Researchers; Glasgow, UK |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation at Experimental Biology conference; Orlando, US. 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Experimental Biology conference; Orlando, US. Networking |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Oral presentation to Eli Lilly; Indianapolis, US, 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Research presentation to Eli Lilly. |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Poster at EASD Incretin Study Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | AEA Poster at Incretin Study Group "The role of glucose-dependent insulinotropic polypeptide receptor-expressing neurons in the hypothalamus" |
| Year(s) Of Engagement Activity | 2019 |
| Description | AEA. Poster at NovoNordisk Foundation Metabolism in Action conference; Copenhagen, Denmark 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation at Novonordisk Foundation Metabolism in Action conference; Copenhagen, Denmark. Sparked debate. |
| Year(s) Of Engagement Activity | 2019 |
| Description | BBC Radio Cambridgeshire Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with BBC Radio Cambridgeshire, to discuss gut brain signalling, and the upcoming public lecture at the Science Festival |
| Year(s) Of Engagement Activity | 2017 |
| Description | Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Big Biology Day - engagement activities explaining metabolic research to families |
| Year(s) Of Engagement Activity | 2017 |
| Description | CAS. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | CAS. Poster at EASD incretin study group: "Tracking the development and release of hormone-containing vesicles in murine L-cells" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Big Weekend |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | hands on events loosley based on the Units research |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cambridge Network recruitment event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay presented at the Cambridge Network recruitment event: "Proglucagon peptide analysis in post gastrectomy patients - bioanalysis or gut feeling?" to people interested in science jobs in the Cambridge area. (asked to present by Mike Van Der Merwe at LGC) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge Science Festival - Right Diet debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Audience reported change in views, opinions or behaviours |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.sciencefestival.cam.ac.uk/events/there-right-diet-me |
| Description | Cambridge Science Festival - family activities |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Drop-in hands-on event for families and children. Sparked questions from children and parents |
| Year(s) Of Engagement Activity | 2016,2017,2018 |
| Description | Cambridge Science Festival 2014 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands on activity for children sparked discussions with children and parents Very positive feedback from public |
| Year(s) Of Engagement Activity | 2014 |
| Description | Cambridge Science Festival Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public Lecture: Gribble and Fletcher. "Inside out: how the gut changes the brain's view of the world". Followed by questions from the public |
| Year(s) Of Engagement Activity | 2017 |
| Description | Cambridge Science festival, family weekends |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | promoted interest in science taking place at the inst |
| Year(s) Of Engagement Activity | 2013,2014,2015 |
| Description | Cambridgeshire Girlguiding Girls in STEM event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Cambridgeshire Girlguiding Girls in STEM event |
| Year(s) Of Engagement Activity | 2020 |
| Description | Careers day at Presdales Secondary School (Cheryl Brighton) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Speed-dating job careers advise sparked interesting and stimulating discussions. Some pupils expressed interest in a career in Science - to early to judge longterm impact. |
| Year(s) Of Engagement Activity | 2014 |
| Description | DG Poster at EASD study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Developing 2D organoid cultures to study intracellular signalling in enteroendocrine cells" |
| Year(s) Of Engagement Activity | 2017 |
| Description | DG Poster at EASD study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DG. Poster at Incretin Study Group: "Modelling human enteroendocrine cells using adult intestinal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | DG. Poster at Copenhagen Biosciences Conference on Intestinal Organoids 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Modelling hormone secretion in human enteroendocrine cells using adult intestinal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Diabetes UK Aug 2014 (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Discussed new treatments for diabetes and their benefits and limitations Patients expressed interest that we are performing research that might improve future therapies |
| Year(s) Of Engagement Activity | 2014 |
| Description | Diabetes UK July 2014 Huntingdon group (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Many questions answered about diabetes treatments Patients better informed about diabetes treatments |
| Year(s) Of Engagement Activity | 2014 |
| Description | EASD poster 2013 (AEA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interesting discussions around data presented on poster Interesting discussion and future collaborations discussed |
| Year(s) Of Engagement Activity | 2013 |
| Description | EASD poster 2013 (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | EASD poster 2014 (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | poster presentation |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered interesting discussion and collaboration Triggered interesting discussion |
| Year(s) Of Engagement Activity | 2014 |
| Description | EB. Poster at Academic Foundation Programme and NIHR BRC and BTRU Trainee's Annual Research Day 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Localisation and characterisation of glucose-dependent insulinotropic polypeptide receptor (GIPR) expressing cells" |
| Year(s) Of Engagement Activity | 2018 |
| Description | EB. Poster at EASD annual professional meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "GLP1R antibody development and characterisation" |
| Year(s) Of Engagement Activity | 2017 |
| Description | EB. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Development of a GLP-1R antagonistic antibody" |
| Year(s) Of Engagement Activity | 2017 |
| Description | EM. Poster at Copenhagen Bioscience Conference on Intestinal Organoids 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM Poster. "Using human duodenal organoids to study motilin production and secretion" |
| Year(s) Of Engagement Activity | 2019 |
| Description | EM. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | EM. Poster at EASD incretin study group. "The contribution of TRP channels to L-cell signalling" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FG, BBC Horizon Special - Right Diet for You |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 3-part BBC2 horizon series |
| Year(s) Of Engagement Activity | 2015 |
| Description | FG, BBC Radio 4 programme, Inside Health |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 'Discussion of publication: "Diagnosis of gestational diabetes: falling through the net" |
| Year(s) Of Engagement Activity | 2015 |
| Description | FG, Press release, article covered by BBC News and multiple international medical publications |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | 'Discussion of publication: "Diagnosis of gestational diabetes: falling through the net" |
| Year(s) Of Engagement Activity | 2015 |
| Description | FR SSIB annual meeting 2019 - poster presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | SSIB annual meeting 09-13Jul2019 (poster): "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR oral presentation at EASD annual meeting 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | oral presentation "GLP-1 secreting enteroendocrine cells co-release ATP to modulate vagal afferent neuronal activity" delivered on 05Oct2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | FR oral presentation at Wellcome Trust meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wellcome Meeting at Sanger 31Jan-01Feb2019 (oral): "A role of hypothalamic glucose-dependent insulinotropic polypeptide receptor (GIPR) in feeding behaviour" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR. Poster at EASD incretin study group. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | FR poster at EASD study group: "Classification of colonic enteroendocrine cells based on single cell mRNA expression analysis" |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR. presentation at Danish Diabetes Academy Winter School for postdoctoral researchers, at Higuerõn Hotel in Malaga/Spain 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Incretins along the gut-pancreas-brain axis". |
| Year(s) Of Engagement Activity | 2019 |
| Description | FR: Mercodia Diagnostics, Uppsala. Invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited to talk to Mercodia about how our mass spec analysis methods complement their immunoassay development |
| Year(s) Of Engagement Activity | 2019 |
| Description | Familial Gastric Cancer Study Day (Geoff Roberts) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | 80-100 participants and family members, with familial gastric cancer, attended a study day to learn more about current research and practice. Geoff Roberts was one of the invited speakers. A number of patients expressed an interest in participating in our future research |
| Year(s) Of Engagement Activity | 2016 |
| Description | GPR. Cambridge UGI cancer symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | "The post-gastrectomy patient, metabolic considerations" |
| Year(s) Of Engagement Activity | 2018 |
| Description | GPR. Talk at EASD incretin study group meeting 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Total Gastrectomy with Roux-en-Y reconstruction results in significant changes in gut hormone and glucose homeostasis" |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited seminar at Genomics Institute of Novartis Research Foundation (FMG) 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion about Novartis' drug development program The researchers at Novartis used my expertise to help in their ongoing drug development program targeting intestinal enteroendocrine cells |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited seminar at Technische Universität München (FMG) 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Sparked discussion and potential collaboration |
| Year(s) Of Engagement Activity | 2013 |
| Description | Invited seminar at UCL (FMG) 2013 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered discussion and further experiments that we tried together Further joint experiments following discussions on the day |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited talk at Paris Descartes (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | The speaker, P.Richards, was offered a research position on the basis of this talk Career progression for P.Richards |
| Year(s) Of Engagement Activity | 2014 |
| Description | JL. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | JL. Poster at EASD study group. "RXFP4, the cognate receptor for insulin-like peptide 5, alters food preference in mice" |
| Year(s) Of Engagement Activity | 2019 |
| Description | LB. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Synergistic effects of concomitant activation of FFAR1 and GPBAR-1 on L-cell calcium and secretory responses" |
| Year(s) Of Engagement Activity | 2017 |
| Description | MRC Centenary Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A hands-on practical demonstration, devised and manned by researchers from our group. The practical was based on sweet taste perception and targeted at members of the public. Engaged participation and interesting discussions with the public Well received from feedback |
| Year(s) Of Engagement Activity | 2013 |
| Description | MRL Science Slam |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The presenters (a post doc and student together) won a prize for their presentation |
| Year(s) Of Engagement Activity | 2018 |
| Description | MY Poster at Incretin Study Group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Characterisation of Electrical Activity in STC-1 Cells and their relevance to study Voltage-gated Ion Channels in Primary K- and L-cells |
| Year(s) Of Engagement Activity | 2017 |
| Description | MY Poster at Incretin Study Group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | MY poster at Incretin Study Group: "Amino acid sensing in K and L cells from mouse duodenal organoids" |
| Year(s) Of Engagement Activity | 2019 |
| Description | MY. Oral presentation at Diabetes UK Annual Professional Conference 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Metformin alters glucose uptake and metabolism in intestinal cells |
| Year(s) Of Engagement Activity | 2019 |
| Description | OW. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | OW poster at EASD incretin study group: "Distribution of G protein coupled relaxin/insulin-like family peptide receptor-4 (RXFP4) expressing cells in the mouse brain" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Oxfordshire Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Audience reported change in views, opinions or behaviours |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.sciencefestival.cam.ac.uk/events/there-right-diet-me |
| Description | PL. Poster at Incretin Study Group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "SCFAs increase PYY but not GLP1 production in human L-cells " |
| Year(s) Of Engagement Activity | 2017 |
| Description | PL. Talk at Incretin Study Group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | PL. Talk at Incretin Study Group. "Peptidomics to study enteroendocrine cells after bariatric surgery" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Professional PhD Networking forum AgroParistech and ABIES doctoral school Doc'Avenir |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Pierre Larraufie: Professional PhD Networking forum AgroParistech and ABIES doctoral school Doc'Avenir, 2017, Round table invited speaker about positions and career after a PhD. |
| Year(s) Of Engagement Activity | 2017 |
| Description | REF Poster at SymBLS 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at DMDG open meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | "Size Exclusion Chromatography for Measuring Free and Antibody-bound Insulin in Hiratas Patients" |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | REF poster at EASD study group "A multiplex method for quantifying gut hormone peptides using Mass Spectrometry" |
| Year(s) Of Engagement Activity | 2019 |
| Description | REF. Poster at REID Bioanalytical Forum 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Immunoassay vs Mass Spectrometry -Measuring insulin and insulin analogues in human plasma |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. American Society for Mass Spectrometry (ASMS) 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Waters user group meeting, presentation: "LC-MS analysis of plasma from patients with insulin autoimmune syndrome" Waters MS focused user meeting (Pharmaceutical track) Outcome: Video of talk available on Waters website, video interview on Select Science website, as well as an in-lab video interview. |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Development of a rapid extraction method for the analysis of gut peptide hormones by LC-MS/MS" |
| Year(s) Of Engagement Activity | 2017 |
| Description | RGK. Poster at EASD incretin study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster at EASD incretin study group: "Proglucagon peptide analysis - will the real peptide please stand up!" |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Reid Bioanalytical Forum 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | "LC-MS analysis of plasma from patients with insulin autoimmune syndrome" Meeting focussing on broad bioanalytical approaches for wide range of analytes Outcome: Video interview by Bionalaysis zone, available on their website |
| Year(s) Of Engagement Activity | 2019 |
| Description | RGK. Waters UK and Ireland Clinical User Meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Waters UK and Ireland Clinical User Meeting 2019 "LCMS Analysis of Proinsulin Derived Peptides" Waters meeting for users of MS systems in clinical environments |
| Year(s) Of Engagement Activity | 2019 |
| Description | SG. Poster at EASD incretin study group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | SG. Poster at EASD study group. "Characterisation of novel gut-derived peptides in vivo and in vitro" |
| Year(s) Of Engagement Activity | 2019 |
| Description | SG. Poster at EASD incretin study group 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | LC-MS based detection of insulin-like peptide 5 in primary colonic cultures |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit (CM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A practical demonstration and associated discussion of the gut, presented by 2 of our PhD students to pupils at a local school. Good feedback |
| Year(s) Of Engagement Activity | 2013 |
| Description | Science lesson at primary school (CLM) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Triggered interesting discussions Greater interest in science and medicine |
| Year(s) Of Engagement Activity | 2012 |
| Description | Seminar at University of Sheffield (FMG) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interesting discussion and plans for future collaboration The Sheffield group have employed one of our previous summer students to do a PhD, and we plan to work together on gut hormone effects on intestinal afferent nerves |
| Year(s) Of Engagement Activity | 2014 |
| Description | Stimulating innovation, experiences working with industry (CLM) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Stimulated discussion |
| Year(s) Of Engagement Activity | 2013 |
| Description | Suffolk Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Suffolk Science Festival |
| Year(s) Of Engagement Activity | 2020 |
| Description | Summer school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Alison Douglas Summer School, for ~30 early career researchers from around Europe. I led an interactive morning session on gut hormones. Very positive feedback received (scored as best presentation from feedback forms) |
| Year(s) Of Engagement Activity | 2013 |
| Description | TD. Poster at EASD study group 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | TD. Poster at EASD incretin study group. "Neutral amino acid transporter: SLC6a19- linking amino acid sensing to gut hormone secretion?" |
| Year(s) Of Engagement Activity | 2019 |
| Description | Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay was Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course. A three day course held at Loughborough University, focussed on the dissemination of knowledge for developing bioanalytical methodologies for large molecule analytes. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Richard Kay was Tutor on the Drug Metabolism and Discussion Group (DMDG) large molecule bioanalysis course. A three day course held at Loughborough University, focussed on the dissemination of knowledge for developing bioanalytical methodologies for large molecule analytes. |
| Year(s) Of Engagement Activity | 2017 |
| Description | VBL talk at Incretin 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | VBL talk at EASD Incretin Study group, "Adenosine triphosphate (ATP) is released from glucagon-like peptide 1 (GLP-1) secreting cells and signals to vagal afferent neurons" |
| Year(s) Of Engagement Activity | 2019 |
| Description | VBL. Poster at Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | VBL presented a poster at a local Cambridge Neuroscience Association meeting at Robinson College on March 14th, 2019. It was called "Cambridge Neuroscience Seminar 2019: Signalling, Sensation & Sentience" and the poster title was "ATP is released from GLP-1 secreting enteroendocrine cells and signals to vagal afferent neruones". It was a valuable experience sharing our work on gut-brain signalling to the larger Cambridge neuroscience community. |
| Year(s) Of Engagement Activity | 2019 |
| Description | WT PhD Studentship meeting (London 2013) (PR) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | poster presentation |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Triggered discussion |
| Year(s) Of Engagement Activity | 2013 |