From Mendelian Randomization to Hypothesis Free Causal Inference

Lead Research Organisation: University of Bristol

Abstract

Obtaining reliable evidence on causes of disease and influences on disease progression is problematic, since many other factors than the ones under study may influence the outcomes. Using genetic variants that mimic potentially modifiable factors that may cause disease or influence its course has become a widely-used approach to improving such understanding. Known as “Mendelian randomization” the methodology is still under development. This programme of work will contribute to strengthening the reliability of the approach, and, in particular, investigate the application to identifying treatments for existing disease.

Technical Summary

Scientific abstract
Background: The MRC Integrative Epidemiology Unit (MRC-IEU) has pioneered the Mendelian randomization (MR) approach, which is now showing exponential growth in terms of breadth of application and number of publications. This has been fuelled by the coalescence of four trends (1) the rapid increase in the number of identified genetic variants related to exposures of interest to clinical investigators; (2) the maturation of UK Biobank and other large-scale population studies with accessible data, including from genome wide association study (GWAS) analysis; (3) the expansion in available data from GWAS consortia; and (4) the popularization of 2-sample MR analyses (2SMR), which allow causal estimates to be made from summary level data. We have developed a range of new methods that allow stronger inference to be drawn from MR studies and released a platform (MR-Base) for high-throughput 2SMR analysis. Both have been rapidly taken up by the scientific community. Our aims will considerably expand the range of questions that MR can address, include:
Aim 1: To increase the clinical utility of MR by conducting studies of disease progression, which will provide MR evidence that speaks directly to disease treatment
Aim 2: To develop approaches that subject the MR assumptions to further scrutiny through negative controls and the assessment of pleiotropy, together with developing structural equation modelling as a flexible strategy for analysis of MR studies
Aim 3: To conduct MR studies in family based data, which provides additional robustness checks, and allows estimation of maternal and paternal influences on offspring outcomes
Methods: The three aims will be advanced in parallel, within a programme that will utilise simulation, substantive analysis, replication and triangulation of evidence.
Translation will be facilitated by the new NIHR Bristol Biomedical Research Centre (Davey Smith Scientific Director) and through expanding our collaborations with industry.

Organisations

Publications

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Adams CD (2019) Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

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Ala-Korpela M (2019) Commentary: Data-driven subgrouping in epidemiology and medicine in International Journal of Epidemiology

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Ala-Korpela M (2016) Metabolomics in cardiovascular medicine: Not personalised, not diagnostic. in European journal of preventive cardiology

 
Description AHA Scientific Statement
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL http://circ.ahajournals.org/content/early/2015/08/03/CIR.0000000000000228
 
Description Citation in NIHR report for the Royal College of Midwives
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
Impact Improved long term outcomes and quality of life of offspring of mothers who , as a result of these report, will avoid a number of toxic exposures while pregnant.
URL http://www.dc.nihr.ac.uk/themed-reviews/better-beginnings.htm
 
Description Presentation at All Party Parliamentary Group on Fetal Alcohol Spectrum Disorder
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://twitter.com/CLAHRC_West/status/935151647809994756
 
Description A systems based approach to integrating genetic and longitudinal omics datga to support diagnosis and predictiion of common chronic disease
Amount £3,369,122 (GBP)
Funding ID MR/M004422/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2014 
End 08/2019
 
Description Appraising the causal relevance of fatty acids in cancer through two-sample Mendelian randomisation
Amount £144,233 (GBP)
Funding ID A20138 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2015 
End 06/2018
 
Description Behavioural and neurophysiological effects of schizophrenia risk genes
Amount £789,477 (GBP)
Funding ID MR/K004360/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2017
 
Description Benjamin Meaker Visiting Professorship
Amount £2,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 02/2017
 
Description Benjamin Meaker Visiting Professorship (LMIC)
Amount £4,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 08/2018
 
Description CHDI Foundation
Amount £117,059 (GBP)
Organisation CHDI Foundation 
Sector Charity/Non Profit
Country United States
Start 04/2017 
End 03/2019
 
Description CRUK Fellowship
Amount £144,234 (GBP)
Funding ID C52724/A20138 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2015 
End 06/2018
 
Description Developmentg and application of a Medelian randomization framework aimed at dissecting the biological basis of ankylosing spondylitis and other complex diseases
Amount $279,666 (AUD)
Organisation University of Sydney 
Department NHMRC Clinical Trials Centre
Sector Academic/University
Country Australia
Start 01/2017 
End 12/2019
 
Description Epigenetics: Enviornment, Embodiment and Equality (E4)
Amount £667,460 (GBP)
Funding ID ES/N000498/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Excessive drinking and alcohol related harms in Adulthood: ALSPAC at 24
Amount £1,378,535 (GBP)
Funding ID MR/L022206/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2015 
End 05/2019
 
Description Future Leaders
Amount £222,571 (GBP)
Funding ID ES/N000757/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Future Research Leaders Grant
Amount £222,571 (GBP)
Funding ID ES/N000757/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description INTERpreting epigenetic signatures in Studies of Early Life Adversity (InterStELA)
Amount £249,391 (GBP)
Funding ID ES/N000382/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2015 
End 08/2017
 
Description In utero exposure to heavy metals: effects on child development
Amount £240,000 (GBP)
Funding ID 104077/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Investigation of aetological mechanisms of atopic dermatitis: from genetic associations to causal mechanisms
Amount £784,279 (GBP)
Organisation Sir Henry Dale Fellowships 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
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Description Investigation of the causal effects of atopic eczema on other health outcomes
Amount £89,968 (GBP)
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Start 11/2016 
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Description MRC IEU doctoral studentship
Amount £93,000 (GBP)
Organisation University of Bristol 
Department MRC Integrative Epidemiology Unit
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 09/2019
 
Description Mapping phenotypic to genetic variability in the High Bone Mass Study
Amount £355,425 (GBP)
Funding ID 20000 
Organisation Versus Arthritis 
Start 01/2013 
End 12/2018
 
Description Medical Research Council Grant
Amount £1,378,535 (GBP)
Funding ID MR/L022206/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 05/2019
 
Description Molecular, Genetic and Lifecourse Epidemiology. PhD programme to provide 3 PhD students per year for 3 years
Amount £1,352,529 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2018
 
Description Moledular, Genetic and Lifecourse Epidemiology
Amount £1,352,529 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2022
 
Description Neurodevelopmental disorders: What happens when children grow up and why?
Amount £893,353 (GBP)
Funding ID 204895/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2021
 
Description Novel epidemiological methods to infer the causal effects of risk factors on neuropsychiatric and cardiovascular disorders
Amount $358,957 (AUD)
Funding ID APP1079583 
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2015 
End 12/2017
 
Description Novel ways of utilizing genome-wide DNA methylation datga from peripheral blood samples in genetic epidemiology
Amount $279,398 (AUD)
Organisation University of Sydney 
Department NHMRC Clinical Trials Centre
Sector Academic/University
Country Australia
Start 01/2015 
End 12/2017
 
Description Provision of high-resolution proteomics to enhance forward and back translational research
Amount £399,998 (GBP)
Funding ID 104914/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 08/2019
 
Description Research Council of Norway - HEALT-GAP. Health, maturity, and the gender gap in education
Amount kr 14,847,000 (NOK)
Organisation Research Council of Norway 
Sector Public
Country Norway
Start 01/2018 
End 08/2022
 
Description SPHERE - a sensor platform for Healthcare in a residential environment
Amount £11,793,922 (GBP)
Funding ID EP/K031910/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2018
 
Description Sir Henry Dale Fellowship: Statistical methodology for population genetics inference from massive datasets with applications in epidemiology
Amount £593,514 (GBP)
Funding ID 104125/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 09/2019
 
Description Studentship - CASE studentship with GSK - Classifying mechanisms of pleiotropy to improve causal modelling.
Amount £96,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 10/2021
 
Description Study of Emerging Adulthood and Cardiomatic Health in ALSPAC: The Influence and of growth and other exposures
Amount £999,049 (GBP)
Funding ID CS/15/6/31468 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2015 
End 06/2020
 
Description The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019
Amount £7,903,667 (GBP)
Funding ID 102215/Z/13/Z 
Organisation Wellcome Trust 
Department Wellcome - MRC Cambridge Stem Cell Institute
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description The association between BMI and EBV with the risk of MS: a Mendelian randomization analysis
Amount $114,500 (CAD)
Funding ID 2672 
Organisation Multiple Sclerosis Society of Canada 
Sector Charity/Non Profit
Country Canada
Start 04/2016 
End 03/2017
 
Description The long-term effects of increased alcohol availability: a natural experiment.
Amount 4,030,000 kr (SEK)
Organisation Government of Sweden 
Sector Public
Country Sweden
Start 01/2013 
End 12/2016
 
Description Training fellowship Chronic irritability in ADHD: examining clinical and genetic links with depression
Amount £459,626 (GBP)
Funding ID 104408/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2014 
End 07/2017
 
Description Twins UK (2017-2019) - An Epidemiological and Genomic Resource
Amount £1,498,934 (GBP)
Funding ID 202786/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2019
 
Description University of Bristol International Strategic Fund
Amount £2,000 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 09/2017
 
Description Using Methods in Genetic Epidemiology to Elucidate the Relationship between Viral Infection and Risk of Autoimmune Disease
Amount $6,222,445 (AUD)
Organisation University of Sydney 
Department NHMRC Clinical Trials Centre
Sector Academic/University
Country Australia
Start 01/2017 
End 12/2019
 
Description Using genetic data to identify early determinants and causal environmental risk factors for Alzheimer's disease
Amount £61,373 (GBP)
Organisation BRACE (Alzheimer's disease charity) 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 10/2017
 
Description Wellcome Trust Grant - Investigating the influence of vitamin D status on cognitive and motor development in young African children
Amount £120,000 (GBP)
Funding ID 209640 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2018 
End 03/2021
 
Description Wellcome Trust Grant - Neurodevelopmental disorders: what happens when children grow up and why?
Amount £697,000 (GBP)
Funding ID 204895/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 12/2021
 
Description Association between dietary measures and later development of psychotic symptoms in the ALSPAC cohort 
Organisation University of Warwick
Country United Kingdom 
Sector Academic/University 
PI Contribution We have formalised and started to carry out Mendelian randomization analyses to investigate causality in associations between omega-3 fatty acids and psychosis. Within Bristol, with other IEU members, we have formed a Fatty Acids MR Working Group to identify fatty acid instruments and consolidate analysis plans
Collaborator Contribution We have worked with our partners in formalising observational and Mendelian randomisation analysis plans and interpreting preliminary results
Impact As of yet we have no outcomes from this project but we aim to produce a paper by the end of this year
Start Year 2016
 
Description Bissau-vaccination 
Organisation The Statens Serum Institute (SSI)
Country Denmark 
Sector Public 
PI Contribution IEU processed and analysed epigenetic samples, provided by collaboration
Collaborator Contribution Samples provided by collaboration
Impact Not known as yet - expected 2017
Start Year 2016
 
Description Cognitive phenotypes 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Planned a project based on data from the Philadelphia Neurodevelopmental Cohort, ALSPAC and MoBa
Collaborator Contribution Planned a project based on data from the Philadelphia Neurodevelopmental Cohort, ALSPAC and MoBa
Impact Multi-disciplinary collaboration; psychology, medicine, biostatistics, genetics
Start Year 2016
 
Description Commercial collaboration with LivingDNA 
Organisation Living DNA Ltd
PI Contribution This is a commercialisation of our research. I provided modifications to our code to enable LivingDNA to use our research for commercial personal ancestry purposes. I also provided research effort to create an appropriate reference dataset.
Collaborator Contribution They provided the commercial services including computation, website, advertising etc as well as expert contacts who assisted with data curation.
Impact No outputs as yes. Outcomes: you can purchase this product from them.
Start Year 2015
 
Description De novo mutations 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution Planning, data analyses and writing articles, presented at the ECNP conference
Collaborator Contribution Contributed to planning, data analyses and writing articles
Impact Journal article in press; Bishop SL, Farmer C, Bal V, Robinson EB, Willsey J, Werling D, Havdahl KA, Sander SJ, Thurm A. (In press). Identification of Developmental and Behavioral Markers Associated With Genetic Abnormalities in Autism Spectrum Disorder. American Journal of Psychiatry. Multi-disciplinary collaboration; psychology, medicine, biostatistics, genetics.
Start Year 2015
 
Description Diamantina Institute, Qld 
Organisation University of Queensland
Department University of Queensland Diamantina Institute
Country Australia 
Sector Academic/University 
PI Contribution Initial collaboration between MRC IEU on start up of Unit
Collaborator Contribution Initial collaboration between MRC IEU on start up of Unit
Impact Too early to list outputs or outcomes
Start Year 2013
 
Description ENIGMA-Anorexia 
Organisation University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution Analysis of imaging phenotype in anorexia
Collaborator Contribution Analysis of imaging phenotype in anorexia
Impact Not known at this time but expected in 2017
Start Year 2016
 
Description Gene-Breastfeeding interaction working group 
Organisation Federal University of Pelotas (UFPel)
Country Brazil 
Sector Academic/University 
PI Contribution Coordination of the project, including contacting studies for participation, developing and sharing analysis plan and scripts, and scientific paper writing. We also analysed data for the studies from our institutions.
Collaborator Contribution Data analysis and summary association results sharing.
Impact Scientific publication: 27311901 (Jun 2016)
Start Year 2016
 
Description GoDMC 
Organisation Genetics of DNA Methylation Consortium
Country Unknown 
Sector Learned Society 
PI Contribution Running large meta analysis of genetic associations in DNA methylation, amongst 40 cohorts
Collaborator Contribution Running large meta analysis of genetic associations in DNA methylation, amongst 40 cohorts
Impact No outcomes known as yet
Start Year 2014
 
Description INSERM 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Public 
PI Contribution On-going collaboration with colleagues from a previous post at UCL
Collaborator Contribution Colleagues served as advisors and co-authors while at UCL and Bristol
Impact No known impact as yet
Start Year 2012
 
Description Knowledge transfer project on the current evidence of safety of alcohol use in pregnancy 
Organisation National Institute for Health Research
Department NIHR CLAHRC West
Country United Kingdom 
Sector Public 
PI Contribution initiated the collaboration, drafted a program of work, oversaw recruitment of a new post-doc to work on the project for 24 months, supervised (line-managed) the post-doc, supervised the completion of 2 papers submitted for publication, organised a PPI workshop for new mums to talk about implementation of new alcohol in pregnancy recommendations and their thoughts on this, contributed to revised UK Chief Medical Officer guidelines on alcohol in pregnancy by submitting an interim report on our evidence synthesis work
Collaborator Contribution gave input towards the general outline of the project, provided financial cover for the post-doc salary for 24 months, helped in recruiting the post-doc, supervised technical aspects of the evidence synthesis project
Impact A 24 months post-doc research contract has been issued for a post-doc to work on this knowledge-transfer project. Multi-disciplinary collaboration, involving : evidence synthesis of epidemiological research, searches and collation of current guidelines/advice from public health, healthcare practitioners and relevant societies, proposed revision of policies. 2 papers submitted for publication, 2 conference presentations, PPI workshop for new mums to talk about implementation of new alcohol in pregnancy recommendations and their thoughts on this, contributed to revised UK Chief Medical Officer guidelines on alcohol in pregnancy by submitting an interim report on our evidence synthesis work, contributed to NIHR Dissemination Centre's "Better Beginnings" publication with summary of evidence on effects of alcohol in pregnancy
Start Year 2014
 
Description MRC centre for Neuropsychiatric Genetics and Genomics, Cardiff University 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Utilizing whole genome data generated from the Cardiff team to test if genetic risk for ADHD and Alzheimer's are associated with relevant traits in children and mothers from ALSPAC.
Collaborator Contribution Provision of whole genome genetic data, expertise on relevant phenotypes
Impact Grant funding from BRACE WT collaborative award 5 publications
Start Year 2014
 
Description MoBa 
Organisation Norwegian Mother and Child Cohort (MoBa)
Country Norway 
Sector Public 
PI Contribution Writing ethical review application for MoBa genetic data, writing a grant for funding of research involving data from MoBa and ALSPAC, and planning of articles based on the collaboration between the IEU and MoBa
Collaborator Contribution Writing ethical review application for MoBa genetic data, writing a grant for funding of research involving data from MoBa and ALSPAC, and planning of articles based on the collaboration between the IEU and MoBa
Impact No outputs with IEU affiliation yet. Multi-disciplinary collaboration; psychology, medicine, biostatistics, genetics
Start Year 2007
 
Description National Centre for Sport & Exercise Medicine, 
Organisation Loughborough University
Country United Kingdom 
Sector Academic/University 
PI Contribution Ongoing collaboration with researchers
Collaborator Contribution Colleagues served as advisors and co-authors
Impact No known impact as yet
Start Year 2012
 
Description Norway resource center for autism 
Organisation Government of Norway
Country Norway 
Sector Public 
PI Contribution Created training material for clinicians and researchers and planned training events
Collaborator Contribution Provided insights into the patient registry data in Norway for use in research
Impact Held short courses for clinicians and researchers in the assessment of autism symptoms
Start Year 2012
 
Description Participation of the 1982 Pelotas Birth Cohort Study in consortia of genome-wide association studies (GWAS) 
Organisation Federal University of Pelotas (UFPel)
Department 1982 Pelotas Birth Cohort
Country Brazil 
Sector Academic/University 
PI Contribution Data analysis, generating summary association results to be combined with the results from other groups by the coordinators.
Collaborator Contribution Coordination of the project, and data analysis. Other participating studies contributed similarly to us. - CHARGE consortium: the Gene-Lifestyle Interactions and mtDNA+ working groups are coordinated by researchers from the School of Medicine at Washington University (USA); the Pulmonary Function working group is coordinated by researchers from the National Institute of Environmental Health Sciences (USA). - The GIANT consortium is coordinated by researchers from the Metabolism Programme at the Broad Institute (USA). - The Human Reproductive Behavior GWAS consortium is coordinated by researchers from the Sociology Department at the Oxford University (UK). - MAGIC is coordinated by researchers from several insitutions, including the Wellcome Trust Sanger Institute (UK), the School of Public Health at the University of Michigan (USA) and the Harvard Medical School at the Harvard University (USA).
Impact No known outcomes to date
Start Year 2015
 
Description Phenotypic measure development 
Organisation Cornell University
Department Weill Cornell Medicine
Country United States 
Sector Academic/University 
PI Contribution Contributed to planning, organized conference calls, performed data analyses
Collaborator Contribution Planning, data analyses and writing articles
Impact Journal commentary in press: Havdahl KA, Hus Bal V, Lord C, Pickles A, Bishop SL. (In press). Measurement of autistic symptomatology in children with neurodevelopmental impairment - In reply. Journal of the American Academy of Child and Adolescent Psychiatry. Multi-disciplinary collaboration; psychology, medicine, biostatistics
Start Year 2015
 
Description Sleep duration, Chrono type and glycaemic traits collaboration 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided advice on future Mendelian randomization analyses to be performed by the collaboration, once robust genetic variants for chronotype have been discovered and validated
Collaborator Contribution Conducted a Genome-Wide association study to uncover genetic determinents of sleep disturbance
Impact Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FAJL, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R. (2017). Genome-wide association studies of sleep disturbance traits identify novel loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nature Genetics 49: 274-281
Start Year 2015
 
Description UCL 
Organisation University College London
Department UCL Genomics
Country United Kingdom 
Sector Academic/University 
PI Contribution Work on paper began while in post at UCL and completed while in post at Bristol
Collaborator Contribution Colleagues served as advisors and co-authors while at UCL and Bristol
Impact No outcomes known at this time
Start Year 2012
 
Description alcohol consumption, ADH1B and cardiovascular disease 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Initiated the collaboration and co-designed the study, provided substantial intellectual input towards the conduct of the project, analysed data for a number of the collaborating studies, wrote sections of the manuscript and commented on several drafts
Collaborator Contribution Collated data from several collaborating studies, performed meta-analysis, drafted manuscript, developed new statistical methodology
Impact PMID: 25192829, PMID: 25011450, PMID: 28025256
Start Year 2010
 
Description alcohol consumption, ADH1B and cardiovascular disease 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Initiated the collaboration and co-designed the study, provided substantial intellectual input towards the conduct of the project, analysed data for a number of the collaborating studies, wrote sections of the manuscript and commented on several drafts
Collaborator Contribution Collated data from several collaborating studies, performed meta-analysis, drafted manuscript, developed new statistical methodology
Impact PMID: 25192829, PMID: 25011450, PMID: 28025256
Start Year 2010
 
Description alcohol, adh1b and chronic disease (CVD and liver disease) 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Hospitals 
PI Contribution I added intellectual content and helped draft 2 papers (one published, one submitted)
Collaborator Contribution Study design, analyses, paper drafting.
Impact PMID 23492672, PMID: 25503943
Start Year 2010
 
Description alcohol, adh1b and chronic disease (CVD and liver disease) 
Organisation Herlev Hospital
Country Denmark 
Sector Hospitals 
PI Contribution I added intellectual content and helped draft 2 papers (one published, one submitted)
Collaborator Contribution Study design, analyses, paper drafting.
Impact PMID 23492672, PMID: 25503943
Start Year 2010
 
Description alcohol, adh1b and chronic disease (CVD and liver disease) 
Organisation University of Bristol
Department School of Social and Community Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution I added intellectual content and helped draft 2 papers (one published, one submitted)
Collaborator Contribution Study design, analyses, paper drafting.
Impact PMID 23492672, PMID: 25503943
Start Year 2010
 
Description candidate genes and alcohol use 
Organisation Aarhus University
Country Denmark 
Sector Academic/University 
PI Contribution I reviewed the literature as background preparation for defining the research questions and planning details of data analysis. I drafted the analysis plan, applied for access to various data, conducted the statistical analysis and drafted the manuscript.
Collaborator Contribution De novo genotyping of one candidate genetic variant in two separate cohort studies and extraction of available in silico data for other studies, help with data handling. Intellectual and scientific input in refining a research question and drafting the manuscript for publication. Permission to use data to conduct analyses.
Impact PMID: 27902751
Start Year 2007
 
Description candidate genes and alcohol use 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Public 
PI Contribution I reviewed the literature as background preparation for defining the research questions and planning details of data analysis. I drafted the analysis plan, applied for access to various data, conducted the statistical analysis and drafted the manuscript.
Collaborator Contribution De novo genotyping of one candidate genetic variant in two separate cohort studies and extraction of available in silico data for other studies, help with data handling. Intellectual and scientific input in refining a research question and drafting the manuscript for publication. Permission to use data to conduct analyses.
Impact PMID: 27902751
Start Year 2007
 
Description candidate genes and alcohol use 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Department Faculty of Epidemiology and Population Health
Country United Kingdom 
Sector Academic/University 
PI Contribution I reviewed the literature as background preparation for defining the research questions and planning details of data analysis. I drafted the analysis plan, applied for access to various data, conducted the statistical analysis and drafted the manuscript.
Collaborator Contribution De novo genotyping of one candidate genetic variant in two separate cohort studies and extraction of available in silico data for other studies, help with data handling. Intellectual and scientific input in refining a research question and drafting the manuscript for publication. Permission to use data to conduct analyses.
Impact PMID: 27902751
Start Year 2007
 
Description candidate genes and alcohol use 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution I reviewed the literature as background preparation for defining the research questions and planning details of data analysis. I drafted the analysis plan, applied for access to various data, conducted the statistical analysis and drafted the manuscript.
Collaborator Contribution De novo genotyping of one candidate genetic variant in two separate cohort studies and extraction of available in silico data for other studies, help with data handling. Intellectual and scientific input in refining a research question and drafting the manuscript for publication. Permission to use data to conduct analyses.
Impact PMID: 27902751
Start Year 2007
 
Description candidate genes and alcohol use 
Organisation University of Western Australia
Department Centre for Genetic Origins of Health and Disease (GOHaD)
Country Australia 
Sector Academic/University 
PI Contribution I reviewed the literature as background preparation for defining the research questions and planning details of data analysis. I drafted the analysis plan, applied for access to various data, conducted the statistical analysis and drafted the manuscript.
Collaborator Contribution De novo genotyping of one candidate genetic variant in two separate cohort studies and extraction of available in silico data for other studies, help with data handling. Intellectual and scientific input in refining a research question and drafting the manuscript for publication. Permission to use data to conduct analyses.
Impact PMID: 27902751
Start Year 2007
 
Description level of response to alcohol 
Organisation University of California, San Diego (UCSD)
Country United States 
Sector Academic/University 
PI Contribution Intellectual contribution to analysis interpretation and drafting of manuscript (PMID: 21762180).
Collaborator Contribution Funding to collect phenotype measures (level of response to alcohol), main analysis and drafting of manuscript.
Impact PMID: 21762180
Start Year 2009
 
Description post-doc fellowship 
Organisation Newcastle University
Department Institute for Ageing and Health
Country United Kingdom 
Sector Academic/University 
PI Contribution I developed the concept for the research to be conducted in collaboration with these centres and collated information to finalise the budget.
Collaborator Contribution Scientific input and feedback towards finalising scientific and training element of a fellowship application.Scientific input and feedback towards finalising scientific and training element of a fellowship application.
Impact Successful application for a post-doc fellowship, the MRC population health scientist fellowship, awarded in April 2010, which started on Sept 30th 2010
Start Year 2009
 
Description post-doc fellowship 
Organisation Norwegian Institute of Public Health
Country Norway 
Sector Academic/University 
PI Contribution I developed the concept for the research to be conducted in collaboration with these centres and collated information to finalise the budget.
Collaborator Contribution Scientific input and feedback towards finalising scientific and training element of a fellowship application.Scientific input and feedback towards finalising scientific and training element of a fellowship application.
Impact Successful application for a post-doc fellowship, the MRC population health scientist fellowship, awarded in April 2010, which started on Sept 30th 2010
Start Year 2009
 
Description prenatal alcohol and growth trajectories 
Organisation University College Cork
Country Ireland 
Sector Academic/University 
PI Contribution intellectual contribution to study design, results interpretation and drafting paper
Collaborator Contribution designed study, ran analyses, drafted paper
Impact PMID: 26073790
Start Year 2013
 
Description prenatal alcohol, adh1b and child athopy and asthma 
Organisation Queen Mary University of London
Department Centre for Primary Care and Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution intellectual contribution to study and help in drafting paper
Collaborator Contribution designed study, ran analyses, drafted paper
Impact PMID 23806636
Start Year 2011
 
Description prenatal alcohol, adh1b and fetal adh1a genotype and conduct problems 
Organisation University of Cambridge
Department Department of Public Health and Primary Care
Country United Kingdom 
Sector Academic/University 
PI Contribution intellectual contribution to study design, results interpretation and drafting paper; obtained funding and arranged genotyping
Collaborator Contribution designed study, ran analyses, drafted paper
Impact PMID: 26588883
Start Year 2013
 
Description prenatal alcohol, adh1b and fetal adh1a genotype and conduct problems 
Organisation University of Oxford
Department National Perinatal Epidemiology Unit Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution intellectual contribution to study design, results interpretation and drafting paper; obtained funding and arranged genotyping
Collaborator Contribution designed study, ran analyses, drafted paper
Impact PMID: 26588883
Start Year 2013
 
Description 1. Instrumental variables symposium Copenhagen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Conference presentation
Year(s) Of Engagement Activity 2016
 
Description 11th SEA Regional Scientific Meeting Nepal 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact 11th SEA Regional Scientific Meeting of the International Epidemiological Association, Pokhara, Nepal 26-29 September 2013. "Writing and publishing in the epidemiological fiedl: the IEA's journal as an example"

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description 2. American Society for Human Nutrition San Diego 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Conference presentation
Year(s) Of Engagement Activity 2016
 
Description 3. Society for Social Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Conference presentation
Year(s) Of Engagement Activity 2016
 
Description 4. Economics MSc introduction to genoeconomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Took part in a discussion of recent developments in social scientific research using genome-wide datasets with graduate (MSc) students
Year(s) Of Engagement Activity 2017
 
Description 6th International Workshop on Geneomic Epidemiology, Royal Society of of London May 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Mendelian Randomization: What does the future hold? 6th International Workshop on Genomic Epidemiology, Royal Society of London, UK. 14th-16th May 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description 81st European Atherosclerosis Society Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact The 81st European Atherosclerosis Society Congress, Lyon, France - 2-5 June 2013. "Epidemiological methods to identify strength of causal associations between risk factors and cardiovascular outcomes"

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description A&E Waiting Times 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio BBC4 Programme - Discussiion of statiscal claims regarding Accident and Emergency Waiting Times

No known impacts
Year(s) Of Engagement Activity 2015
 
Description Anne Faulkner Memorial Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Anne Faulkner Memorial Lecture: The bigger picture: big data, genomics, epigenetics and metabolomics. UK CFS/ME Research Collaborative Annual Science Conference 2015, Ponteland Road`, Newcastle-upon-Tyne, United Kingdom 14th October 2015 - Informed discussion
Year(s) Of Engagement Activity 2015
 
Description Application of Mendelian Randomization to investigating potential epigenetic mediation in the causation of disease, New York 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact CHARGE Epigenetics of Aging and Disease Initiative Workshop. Grand Hyatt New York. Q&A and discussion
Year(s) Of Engagement Activity 2017
 
Description Applications of Mendelian randomization in epigenomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Epigenomics of Common Diseases, Wellcome Genome Campus Conference Centre, Cambridge. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Autism seminar (UCSF) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Autism seminar at UCSF: Held a 20 minute presentation at UCSF STAR Center for Autism Spectrum Disorders and Neurodevelopmental Disorders 401 Parnassus Ave. San Francisco, CA 94143. Name of presentation: "Research use of the Autism Diagnostic Observation Schedule".
Year(s) Of Engagement Activity 2017
 
Description BBC Radio 4. 9th January 2015 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Media interview: Bad Luck and Cancer. More or Less: Behind the Stats, BBC Radio 4. 9th January 2015
Year(s) Of Engagement Activity 2015
 
Description BBC Radio 4: The Life Scientific. 1st March 2016 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio interview on BBC Radio 4: The Life Scientific. 1st March 2016
Year(s) Of Engagement Activity 2016
 
Description BBC Radio Bristol interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact This was a BBC Radio Bristol interview relating to alcohol consumption. The results are unknown

This was a BBC Radio Bristol interview relating to alcohol consumption. The impacts are unknown
Year(s) Of Engagement Activity 2014
 
Description BBC Radio Bristol interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview to talk about cohort studies and their importance in the work carried out at the MRC IEU
Year(s) Of Engagement Activity 2017
 
Description Biannual meeting of the Latin American Association of Genetics (Uruguay) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I gave a talk at the biannual conference of the Latin American Association of Genetics, which took place in Montevideo, Uruguay, October 9-12, 2016. Attendants were geneticists from all over the Americas and invited European speakers. The purpose of my presentation was to introduce Mendelian randomization to a Latin American audience and explore the potential for collaboration.
Year(s) Of Engagement Activity 2016
URL http://alag2016.org
 
Description Big Data - how exploitation of genetic data has led to new insights 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Bone Research Society, Bristol Science Centre. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Big data analytics for genetics in personalized health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The International Genetic Epidemiology Society and the Genomics of Common Disease Programme, Wellcome Genome Campus, Hinxton UK. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Biogen Genetics Days Symposium Boston, October 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Mendelian randomization: testing assumptions and moving to automation. Biogen Genetics Days Symposium, 26-27 October 2015, Boston - informed discussion
Year(s) Of Engagement Activity 2015
 
Description Biomentric Society Meeting November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Mendelian randomization: What does the future hold? Biometric Society Meeting on Mendelian Randomisation, London School of Hygiene and Tropical Medicine, London, UK. 14th November 2014 - Informed discussion
Year(s) Of Engagement Activity 2014
 
Description Birth Cohort Research, Copenhagen, October 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Integrating genetic and other omic data into birth cohort studies. Birth Cohort ResearchPast, Present, and Future contributions to Public Health. The Christian Hansen Auditorium, Copenhagen 1st October 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description British Science Association - People and Science 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact British Science Association : People and Science : December 2013 - Epigenetics: Hope or Hype - Correspondence with Tim Spector

On-line magazine - correspondence with Tim Spector following the Huxley Debate
Year(s) Of Engagement Activity 2013
 
Description British Science Association, Tobacco Factory, Bristol, 26th January 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Presentation: Cancer how much is bad luck? British Science Association, Tobacco Factory, Bristol, 26th January 2015
Year(s) Of Engagement Activity 2015
 
Description CCACE Scientific Themes Discussion Days, Edingurgh November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact An overview of genetic and epigenetic epidemiology. CCACE Scientific Themes Discussion Days, Edinburgh Centre for Carbon Innovation, Edinburgh. 25th November 2014 - informed discussion
Year(s) Of Engagement Activity 2014
 
Description CHDI Foundation November 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Genomics meets population-based cohort studies. CHDI Foundation. The Westin Princeton at Forrestal Village, New Jersey, USA. 20th - 22nd November 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description CHDI Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Informed discussion and questions

Not know at this stage
Year(s) Of Engagement Activity 2015
 
Description CLOSER workshop ''Mixing modes and measurement methods in longitudinal studies' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 30 professionals working in cohort studies primarily academics shared knowledge in the workshop. Mr Ross Robinson, Deputy Executive Director, gave a presentation on ALSPAC experience of mixed mode questionnaires. The aim of the workshop was to share best practices between cohorts.
Year(s) Of Engagement Activity 2016
URL http://www.closer.ac.uk/event/mixing-modes-measurement-methods-longitudinal-studies/
 
Description CLOSER workshop 'Working with biological samples in cohort studies' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Dr Sue Ring, Head of ALSPAC Labs, and colleagues ran this workshop in Bristol. People working in cohort studies throughout the UK were invited to attend.
Year(s) Of Engagement Activity 2016
URL http://www.closer.ac.uk/event/biological-samples-workshop/
 
Description Cancer how much is bad luck? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Cancer how much is bad luck? British Science Association, Tobacco Factory, Bristol - 26th January, 2015. Informed debate and discussion
Year(s) Of Engagement Activity 2015
 
Description Conference Presentation (plenary) - EMBL Big data in biology and health conference, Heidelberg 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presenting MR-Base to other researchers, a tool for integrating big data to make causal inference across the phenome
Year(s) Of Engagement Activity 2016
URL https://www.embl.de/training/events/2016/BIG16-01/
 
Description Confounding by ill health in the observed association between BMI and mortality: evidence from the HUNT Study using offspring BMI as an instrument 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Science Media Centre Press Briefing, Wellcome Trust
Year(s) Of Engagement Activity 2017
 
Description Congress of the International Society Twin Studies (ISTS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion and questions

Possible future collaborations
Year(s) Of Engagement Activity 2014
 
Description Doctor of Laws Degree Congregation Orations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact University of Bristol Doctors of Law Degree Congregation Orations. Professor Jean Golding OBE - 7 - 10 January

Talk at University of Bristol Doctors of Law Degree Congregation Orations.
Year(s) Of Engagement Activity 2013
 
Description Does MR have any place in social sciences? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Professor Dalton Conlay and Professor George Davey Smith Debate - Mendelian Randomization Conference Bristol. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description ECNP Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Held a 20 minute presentation, which was followed by engaged questions and discussion
Year(s) Of Engagement Activity 2016
URL https://www.ecnp.eu/about-ecnp/history/past-ecnp-meetings/pastcongresses//Vienna2016/provisional_pro...
 
Description ERC Causation in Biology Conference, Bristol, September 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Mendelian randomization: strengthening causal inference in observational data by using genetic anchors. ERC Causation in Biology Conference. University of Bristol 2nd and 3rd September 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description Epigenomics of Common Diseases Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion and questions

Networking with colleagues for possible future collaborations.
Year(s) Of Engagement Activity 2014
 
Description Featured in MRC Life 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Featured in MRC Life for various events such as awards and public engagement activities
Year(s) Of Engagement Activity 2017
 
Description From condom distribution in Nicaragua to genetics in Bristol: reflections on a career in academic medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Inspire Showcase, Bristol. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Genetic and epigenetic epidemiology course - Brazil March 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Mendelian Randomisation: The future. Genetic and epigenetic epidemiology course, Pelotas, Brazil. 5th-13th March 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description How Life Gets Under the Skin May 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact How Life Gets Under the Skin. The Epigenome & the Social Environment. M Shed, Bristol, 28th May 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description ICEP Launch Event October 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Is cancer bad luck? Integrative Cancer Epidemiology Programme (ICEP) Launch Event. 21st October 2015 M Shed, UK - informed discussion
Year(s) Of Engagement Activity 2015
 
Description IDEAL Ageing Congress October 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lifecourse and epigenetic processes. IDEAL Ageing Congress, 12-14 October 2015, Leiden The Netherlands - informed discussion
Year(s) Of Engagement Activity 2015
 
Description IMFAR conference (California) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact IMFAR Conference: Held a dissertation award talk, which was followed by engaged questions and discussion. Name of presentation was "Context Matters: Factors influencing assessment of autism features"
Year(s) Of Engagement Activity 2017
 
Description Identifying factors that influence population health: how can genetics help? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk to the South West Public Health Scientific Conference
Year(s) Of Engagement Activity 2017
 
Description Imaging Genetics Conference (California): Feb, 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This conferences aimed at international experts in neuroimaging, genetics, data-mining, visualization and statistics, targeting physicians and scientific researchers alike. My talk was on methodological approaches in imaging (epi-)genetics, followed by a discussion that mainly focussed on the difficulties of cross-tissue correlations, temporal instability and predictive power of epigenetic signals.
Year(s) Of Engagement Activity 2017
URL http://www.imaginggenetics.uci.edu/index.asp
 
Description Impact of Genomics on Public Health November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The use of Genetic Variants as Tools for Epidemiologists. The Impact of Genomics on Public Health, Cardiff, UK. 6th-7th November 2014 - Informed discussion
Year(s) Of Engagement Activity 2014
 
Description Interviews for national and international press 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Following a press-release for the publication of our systematic review on the effects of low levels of alcohol drinking in pregnancy, we received a huge amount of media interest and requests for comments and interviews (on the phone, via email and Skype). (PMID 28775124) Some of the reporting of our results in the media was inaccurate, therefore we also quickly mounted a counter-information campaign (mainly on social media but also by writing letters to relevant national newspapers) to set the record straight.
Year(s) Of Engagement Activity 2017
URL https://twitter.com/i/moments/912617139537940482
 
Description Is cancer bad luck? Queens University Belfast, November 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Is Cancer bad luck. 10-11 November 2015. Queens University Belfast, Belfast - informed discussion
Year(s) Of Engagement Activity 2015
 
Description Is thre a role for epidemiology in the age of big data and multi-omics? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Richard Doll Prize 2017 Lecture. The 21st International Association World Congress of Epidemiology Japan. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Live broadcast - TV and radio 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact In relation to the systematic review on the effects of low levels of alcohol use in pregnancy (PMID 28775124), we were interviewed on live TV for BBC1 Breakfast and the Victoria Derbyshire program. We were also interviewed by a number of national (eg Drivetime) and regional radio channels (eg BBC Scotland, BBC Bristol, BBC Birmingham etc). We took advantage of these interviews to set the record straight on some misleading press headlines that were not representatives of the study's findings.
Year(s) Of Engagement Activity 2017
 
Description Lung Cancer Cohort Consortium Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Lung Cancer Cohort Consortium Meeting, IARC, Lyon, France - 24-25 March, 2014 - 'Mendelian Randomization: relevance for lung cancer epidemiology

Continued collaboration
Year(s) Of Engagement Activity 2014
 
Description MRC Festival of Medical Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Many members of the MRC IEU took part in a series of schools outreach activities with schools groups from across the Bristol and Avon district. This was a three day event that aimed to communicate the interplay of data, genetics and lifestyle choices in the study of epidemiology.
Year(s) Of Engagement Activity 2016
URL https://www.youtube.com/watch?v=UJS-GNsH2Ys&index=3&list=PLSus4fp7v7sTOQqK0KMDFYGtz6OD5E0ps
 
Description MRC Festival of Medical Research - Open House at the IEU 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact As part of the MRC Festival of Medical Research, school groups were invited to the department for a series of activities that aimed to engage them with the study of epidemiology through looking at the interplay of genetics, data analysis and environmental influences. The school pupils were surprised by some of the information we provided on the day and showed great interest in the activities
Year(s) Of Engagement Activity 2016
 
Description MRC IEU What we do. January 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact MRC Integrative Epidemiology Unit - What we do. Physiology and Pharmacology, Medical Sciences Building, University of Bristol. 26th January 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description MRC IEU and link with SPHERE 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact MRC Integrative Epidemiology Unit and the link with SPHERE. EPSRC Interdisciplinary Research Collaboration, University of Bristol, UK - 13 March 2014

Continuing collaboration with SPHERE
Year(s) Of Engagement Activity 2014
 
Description Mendelian Randomization - Biometric Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion and questions

Possible future collaborations. Increased awareness of Mendelian Randomization
Year(s) Of Engagement Activity 2014
 
Description Mendelian Randomization: what does the future hold? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact 7th International Workshop on Genomic Epidemiology, Barcelona. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Mendelian Randomization: what does the future hold?, Massachusetts General Hospital 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference from the CHGR Genomic Medicine Seminar. Massachusetts General Hospital USA. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Mendelian randomization in epigentic studies - New York 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Cohorts for Heart and Aging Research in Genomic Epidemiology Investigator Meeting (CHARGE). Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Mendelian randomization: Scientific Symposium: Frontiers in Epidemiology Tate Memorial Centre Mumbai 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A Scientific Symposium
Year(s) Of Engagement Activity 2017
 
Description Molly Towell Lecture, Banff Canada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Molly Towell Lecture: Can we improve causal inference in perinatal epidemiology? Canadian National Perinatal Research Meeting, Banff, Canada. 12th-15th February 2014. Informed discussion
Year(s) Of Engagement Activity 2014
 
Description More or Less Radio 4 January 2015 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interview on BBC Radio 4 Programme More or Less: Behind the Stats - Bad Luck and Cancer - 9th January, 2015
Year(s) Of Engagement Activity 2015
 
Description New Methods in Mendelian Randomizaton. Polygenic prediction and its application in social science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Centre for Economic and Social Research. University of Southern California. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Newspaper article national and international media 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Newspaper article in the Guardian, Daily Mail, Sydney Morning Herald and The Australian.

Increased awareness of research being carried out on BMI and Asthma
Year(s) Of Engagement Activity 2014
 
Description PRISME Forum Fall 2015 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Health professionals
Results and Impact No known results at this stage

Informed discussion
Year(s) Of Engagement Activity 2015
 
Description PRISME Forum Fall 2015 Technical Meeting, November 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Converting Available Data into Useful Information in the Omics Era. PRISME Forum Fall 2015 Technical Meeting. BMS Plainsboro Campus, New Jersey, USA. 18th - 20th November 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description Perinatal data - a resource for epdemiological research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Medical Birth Registry of Norway's 50th anniversary celebrations. Norwegian Institute of Public Health, Bergen, Norway. Discussion and Q&A
Year(s) Of Engagement Activity 2017
 
Description Pharmaceutical and biotechnology industry event, UoB September 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Keynote lecture: Harnessing population genetics to improve understanding of pharmaceutical targets. Pharmaceutical & biotechnology industry event. Wills Memorial Building, Bristol, 15th September 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description Pop-up Festival of Medical Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The event was well attended with informed discussion and Q&A sessions

Enhancement of awareness of the MRC Integrative Epidemiology Unit at the University of Bristol
Year(s) Of Engagement Activity 2014
 
Description PopNAD Interview Emilie Thern 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Interviewed by PopNAD the popular science part of the Journal Nordic Studies on Alcohol and Drugs. The interview covered the study and trial background and alcohol availability.
Year(s) Of Engagement Activity 2017
 
Description Population Health: Past, Present and Future - University of Michigan, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Debate and discussion on talk entitled ' Is there any hope for the detection of gene by environment interactions?

Symposium - Population Health: Past, Present and Future, University of Michigan, USA - 9 - 11 April, 2014. Continuing collaboration
Year(s) Of Engagement Activity 2014
 
Description Presenting at Bristol Neuroscience Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The festival is a two-day public science event for all ages from primary school to adult celebrating all things neuroscience. Last year more than 200 people attended talks by neuroscience experts. I presented on Genes and Environment in Mental Health and the talk sparked discussion about contributing factors to depression and whether how much can genes determine predisposition to depression. The talks are also available online. http://www.bristol.ac.uk/neuroscience/bnf/2016/lectures/
Year(s) Of Engagement Activity 2016
URL http://www.bristol.ac.uk/neuroscience/bnf/2016/lectures
 
Description Public discussion forum on health data, where it goes, how people can access it 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public discussion forum on health data, where it goes, how people can access it
Year(s) Of Engagement Activity 2017
 
Description Queens University Seminar November 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Informed discussion and questions

No notable impacts known at this stage
Year(s) Of Engagement Activity 2015
 
Description Radio 1 interview with Dr Phil Hammond. 4th February 2017 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio 1 interview with Dr Phil Hammond. 4th February 2017
Year(s) Of Engagement Activity 2017
 
Description Radio 4 Produces : Ideas Club 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio 4 Produces: Ideas Club, The Ship, New Cavendish Street, London, UK - 2 April 2014

Radio 4 interview and discussion
Year(s) Of Engagement Activity 2014
 
Description Reflections on the Midspan Studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion and questions

Possible future collaborations
Year(s) Of Engagement Activity 2014
 
Description Regional resource center for autism 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Regional resource center for autism: Held workshops to improve the quality and standardization of clinical services for individuals with autism spectrum disorder across Norway. Feedback has been very positive and the presentations and short courses held have been full
Year(s) Of Engagement Activity 2010,2017
 
Description Regional resource center for autism 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Co-led a working group aiming to improve the quality and standardization of clinical services for individuals with autism spectrum disorder across
Norway. Feedback has been very positive and the presentations and short courses held have been full
Year(s) Of Engagement Activity 2016
 
Description Reproductive, Perinatal and Pediatric Epidemiology/Maternal and Child Health Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Debate and informed discussion - 'Genetics and epigenetics: transforming or deforming lifecourse research?'

Reproductive, Perinatal and Pediatric Epidemiology/Maternal and Child Health Symposium: "A Life-course Approach to Women's Health", Harvard School of Public Health - 23 January 2014
Year(s) Of Engagement Activity 2014
 
Description School talk - Authentic Biology series, Cotham High School, Bristol 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Presentation and discussion with A-level students about how genetic variation influences population health
Year(s) Of Engagement Activity 2016
 
Description Science Media Centre Background Briefing 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Informed discussion took place with questions from the media

A positive reaction was received
Year(s) Of Engagement Activity 2014
 
Description Seminar for Government Social Researchers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact 100+ delegates from cross-Government departments attended the seminar which allowed for indepth discussion of the subject matter.

Delegates were made aware of new methodologies and challenges arising from the research being undertaken in combining genetic and longitudinal data.
Year(s) Of Engagement Activity 2014
 
Description Several media interviews including regarding published article on paracetamol use during pregnancy 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I was asked for phone and TV interviews by more than 20 different media agents and accommodated as many as I could. Interviews were broadcasted on radio and TV as well as published on electronic and paper newspapers in various countries around the world with a lot of interest from Australia, Canada, US and Europe.
Year(s) Of Engagement Activity 2016
 
Description Specialization seminar for clinical psychologists 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Had a 2 hour lecture for 20 clinical psychologists, which led to increased interest in our research
Year(s) Of Engagement Activity 2016
 
Description Spectrum News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Told the journalist about a newly published study and answered questions about it. The interview was published on the organization´s website and has been shared by
researchers, professional practitioners and patient care organizations in social media
Year(s) Of Engagement Activity 2016
URL https://spectrumnews.org/opinion/q-and-a/questions-bishop-havdahltantrums-trick-autism-tests/
 
Description St Andrews Day Lecture. CCACE Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact St Andrews Day Lecture: Mendelian Randomisation in the multi-omic world. CCACE Scientific Themes Discussion Days, Edinburgh Centre for Carbon Innovation, Edinburgh, UK. 25th November 2014. Informed discussion
Year(s) Of Engagement Activity 2014
 
Description Swiss Epidemiology Winter School, Bern, January 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Epigenetic Epidemiology for Epidemiologists. Swiss Epidemiology Winter School. University of Bern, Switzerland, 19th - 24th January 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description TEDx Bristol 2013 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact TEDx are making a film about Dr Rebecca Peason's work on depressogenic cognitive style in the cohort which will be shown at TEDx as part of the 'Psychology of Failure' theme in which George Davey Smith is a key participant. The resulting film will be available on the TEDx website and ALSPAC's YouTube channel.

The event is taking place on 11 November so too earlier to report on impact.
Year(s) Of Engagement Activity 2013
URL http://tedxbristol.com/
 
Description TWINS Budapest, November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Pre-conference workshop on Causal modelling and twins (Keynote Lecture). TWINS: The Joint 3rd World Congress on Twin Pregnancy and Global Perspective and the 15th Congress of the International Society Twin Studies (ISTS), Budapest, Hungary. 16th November 2014 - Informed discussion
Year(s) Of Engagement Activity 2014
 
Description TWINS pre-conference Budapest November 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote Lecture: Mendelian randomization and beyond: strengthening causal inference in epidemiological and omic sciences. TWINS: The Joint 3rd World Congress on Twin Pregnancy and Global Perspective and the 15th Congress of the International Society Twin Studies (ISTS), Budapest, Hungary. 17th-19th November 2014 - informed discussion
Year(s) Of Engagement Activity 2014
 
Description TWINS the Joint 3rd World Congress on Twins 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion and questions

Stimulated discussion and possible future collaborations.
Year(s) Of Engagement Activity 2014
 
Description Talk to Pfizer, Cambridge, MA, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Discussion and informed debate

Pfizer, Cambridge, MA USA 24th January 2014 - 'How genetic studies can contribute to drug target validation' - continued collaboration
Year(s) Of Engagement Activity 2014
 
Description Target Validation using Genomics and Informatics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Mendelian randomization in target validation. Target Validation using Genomics and Informatics. Wellcome Trust Genome Campus, Cambridge, UK. 8-10 December 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description The Biology of Genomes, Cold Spring Harbor, May 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Mendelian randomization: Harnessing genocopy/phenocopy to identify modifiable causes of disease. The Biology of Genomes. Cold Spring Harbor 5th - 9th May 2015 - informed discussion
Year(s) Of Engagement Activity 2015
 
Description The use of Genetic Variants as Tools for Epidemiologists 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Discussion and questions

Increased awareness of the impact of genomics on public health.
Year(s) Of Engagement Activity 2014
 
Description Three Minute Video Production for YouTube 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Production of three minute primer videos for Met analysis and Mendelian Randomization placed on You Tube
Year(s) Of Engagement Activity 2017
 
Description Training session on Genetic Epidemiology at CLAHRC West 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Training seminar on methods used for Genetic Epidemiology and causal inference for health professionals working for the NHS and linked to CLAHRC West
Year(s) Of Engagement Activity 2016
 
Description Translational Science Update Royal College of Physicians 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Health professionals
Results and Impact Discussion focussed on 'Unravelling gene-environment interactions through epidemiology. Translational science update: today's science shaping tomorrow's clinical practice.

Royal College of Physicians, London - 7th November, 2013 - informed debate
Year(s) Of Engagement Activity 2013
 
Description UK CFS/ME Research Collaborative Annual Science Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Informed debate regarding current and ongoing research. Positive response in Phoenix Rising ME/CFS Blog
Year(s) Of Engagement Activity 2015
URL http://phoenixrising.me/archives/27889
 
Description Wellcome Trust public debate on genetic data privacy, Bristol, 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Debate on the topic of how genetic data is used and how privacy is safeguarded
Year(s) Of Engagement Activity 2016
 
Description Women in Science talk (WiS, Lincoln University): Mar, 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact This talk took place as part of a university-wide initiative on Women's day. I was invited to talk about my life / caeer in Science. The audience asked questions afterwards. The aim was to provide an example of a "successful" research career and to inspire others
Year(s) Of Engagement Activity 2017
URL http://www.lincoln.ac.uk/t4media/pdf/intWomensDayProgramme2017.pdf
 
Description Workshop on Randomization and Related Topics Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Health professionals
Results and Impact Workshop on Randomization and Related Topics in Causal Inference in Medicine. Bristol, 11th June 2013 - "Origins of 'fair tests' of treatment in the late 19th century: how and why"

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description Workshop talk - IEU Workshop on meta-analysis and Mendelian randomization, Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Discussions on using MR-Base to improve causal inference
Year(s) Of Engagement Activity 2016