Epigenetic Epidemiology

Lead Research Organisation: University of Bristol

Abstract

This programme aims to gain a better understanding of the determinants and consequences of epigenetic variation through the use of epidemiological approaches. We will extend our knowledge of the relationship between common genetic variation and DNA methylation across the genome through large scale GWAS analysis. The identification of genetic variants that tag methylation variation will enhance our ability to conduct Mendelian randomization to strengthen causal inference. We will develop our use of DNA methylation as a biomarker of disease prediction and prognosis as well as an index of exposure to disease risk factors. Lastly, we will combine these elements of the programme and other methodological advances in epigenetic epidemiology to address a variety of disease specific research questions.

Technical Summary

Scientific abstract
Background: To maximally exploit the rapid pace of change, including the accrual of large-scale data, in the field of epigenetic epidemiology, we will develop innovative methods for the robust scientific interrogation of population-based epigenetic data and apply them to research questions of scientific and medical importance, structured around four domains:
Aim 1: We will explore the genetic architecture of epigenetic traits and use this information to understand the role that DNA methylation variation plays in health and disease.
Aim 2: We will develop and make readily accessible the causal analysis methods and tools and apply Mendelian randomization (MR) to epigenetic questions.
Aim 3: We will use DNA methylation as an index of past exposures to improve our prediction of disease risk and prognosis.
Aim 4: From neurodevelopment to cancer, there are a multitude of settings in which we can apply epigenetic epidemiology to understand disease mechanisms and predict disease.
Methods: We will utilize multiple data sources; from in-house studies, via collaborations and consortia, and through publicly accessible repositories. Our primary focus will be on the analysis of DNA methylation, as this continues to be the most readily available source of epigenetic data in population-based studies. However, we will integrate these data with newly generated and publicly available epigenomic and transcriptomic data, tissue-specific data and histone modification data.
A wide range of methods will be applied. These include mQTL analysis, functional annotation and machine learning approaches, such as penalized regression, support vector machines, and neural networks. We will test for mediation using MR and apply our prediction methods in disease relevant datasets.
Translation: The output arising from this programme will be used to develop biomarkers of disease risk and disease prognosis. It will also shed light on the genetic architecture of DNA methylation and the causal role this molecular phenotype plays in development and disease, which will in turn inform future interventions.

Organisations

Publications

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Adams CD (2019) Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

 
Description Genetic and Epigenetic Epidemiology Course
Geographic Reach Asia 
Policy Influence Type Influenced training of practitioners or researchers
Impact This course was held in the Tata Memorial Centre for Molecular Epidemiology in Mumbai and involved researchers from across India. We delivered an educational week-long course aimed at capacity building and the development of good research practice in this field in India.
 
Description A statistical framework for epigenetic change
Amount £298,482 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Andrew Simpkin-Biostatistics Fellowship
Amount £352,864 (GBP)
Funding ID MR/L011824/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 02/2018
 
Description CRUK Population Research Committee Project Grant (Rebecca Richmond)
Amount £160,000 (GBP)
Funding ID C57854/A22171 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 07/2019
 
Description Childhood adversity and mid-life reversibility
Amount $250,000 (USD)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2014 
End 08/2016
 
Description Core Programme Support MRC/Wellcome Trust
Amount £7,540,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics (C Relton)
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description De Pass Vice Chancellor's Fellowship - Rebecca Richmond
Amount £260,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 10/2022
 
Description Defining epigenetic predictors of long-term outcomes of pre-term birth
Amount £400,000 (GBP)
Organisation University of Sydney 
Department NHMRC Clinical Trials Centre
Sector Academic/University
Country Australia
Start 01/2015 
End 12/2017
 
Description Does epigenetic methylation explain the gender-switch in adolescent asthma?
Amount $3,137,380 (USD)
Organisation National Institutes of Health Clinical Center 
Sector Hospitals
Country United States
Start 01/2016 
End 01/2021
 
Description ERA-HDHL - Early life programming of childhood health: a nutritional and epigenetic investigation of adiposity and bone, cardiometabolic, neurodevelopmental and respiratory health.
Amount £124,600 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 12/2019
 
Description Epigenetic pathways to conduct problem trajectories: the role of prenatal and postnatal environmental risk exposures
Amount £1,100,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 01/2012 
End 12/2016
 
Description Epigenetics: Environment, Embodiment and equality (E4)
Amount £667,460 (GBP)
Funding ID ES/N000498/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Exploring epigenetic mechanisms in early life programming of obesity and other metabolic disorders
Amount £38,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2010 
End 11/2011
 
Description HDR UK RCUK Innovation/Rutherford Fellowships - Two fellowships (C Relton)
Amount £614,457 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 01/2021
 
Description Interpreting epigenetic signatures in studies of early life adversity (InterSTELA)
Amount £195,513 (GBP)
Funding ID ES/N000382/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2015 
End 07/2018
 
Description Investigation of the causal effects of atopic eczema on other health outcomes
Amount £90,000 (GBP)
Organisation British Skin Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2015 
End 12/2017
 
Description MRC - Creating a West African BioResource for Nutritional Genetics and Epigenetics.
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 01/2019
 
Description MRC Proximity to Discovery Industry Engagement Fund (Tom Richardson)
Amount £12,225 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Human Nutrition Research Unit
Sector Public
Country United Kingdom
Start 08/2016 
End 05/2017
 
Description Mechanistic insights from birth cohorts
Amount $2,500,000 (USD)
Funding ID NIH PAR-13-009 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 10/2014 
End 09/2019
 
Description Medical Research Council
Amount £1,100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2013 
End 03/2018
 
Description NIH - Childhood adversity, DNA methylation and risk for depression: A longitudinal study of sensitive periods in development.
Amount $1,623,764 (USD)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 10/2017 
End 10/2019
 
Description NIH - Consultant (PI - Hambridge M)
Amount $11,000,000 (USD)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 06/2013 
End 05/2018
 
Description Novel ways of utilizing genome-wide DNA methylation data from peripheral blood samples in genetic epidemiology
Amount £400,000 (GBP)
Organisation University of Sydney 
Department NHMRC Clinical Trials Centre
Sector Academic/University
Country Australia
Start 01/2015 
End 12/2017
 
Description One carbon metabolism biomarkers and lung cancer risk
Amount $5,060,000 (USD)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2011 
End 08/2016
 
Description Pfizer
Amount £175,000 (GBP)
Organisation Pfizer Ltd 
Sector Private
Country United Kingdom
Start 12/2013 
End 06/2015
 
Description Provision of high-resolution proteomics to enhance forward and back translational research
Amount £399,998 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 08/2019
 
Description Roy Castle Lung Cancer Foundation
Amount £74,990 (GBP)
Organisation Roy Castle Lung Cancer Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2013 
End 03/2015
 
Description S1P1R genetic profiles in endothelial function and epigenomic contributions to chronic pain
Amount £500,000 (GBP)
Organisation Sanofi 
Sector Private
Country Global
Start 01/2016 
End 12/2018
 
Description Study of emerging adulthood and cardiometabolic health in ALSPAC: the influence of growth and other exposures (SEA CHANGE)
Amount £999,049 (GBP)
Funding ID CS/15/6/31468 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2015 
End 07/2020
 
Description The Born in Bradford (BiB) Study - an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population
Amount £1,481,389 (GBP)
Funding ID 101597/Z/13/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2013 
End 08/2018
 
Description UKRI/Rutherford Health Data Research Fellowships (2)
Amount £614,455 (GBP)
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 02/2018 
End 02/2021
 
Description Understanding Society Biomarker Data Fellowship (Rebecca Richmond)
Amount £47,000 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description Wellcome Trust - Co-Investigator (PI Lawlor DA)
Amount £1,481,389 (GBP)
Funding ID 100104/Z/12/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2013 
End 08/2018
 
Title ARIES Explorer 
Description ARIES Explorer - data available via ALSPAC data access process 
Type Of Material Data handling & control 
Year Produced 2013 
Provided To Others? Yes  
Impact The ARIES-Explorer web interface was launched on the resource website (http://www.ariesepigenomics.org.uk) in November 2013. AWStats analysis of webserver log files show that in the first month following data release (Nov 2013) the website received 872 visits from 419 unique visitors (250MB of data transferred). The site is indexed by Google, Bing and Baidu and currently receives around 50 hits per day. 
URL http://www.ariesepigenomics.org.uk
 
Title GoDMC github repository 
Description This is a github repository developed for the GoDMC. 30+ GoDMC cohorts will download the pipeline and will follow instructions to run the pipeline. Briefly, the analyses are splitted into 3 broad stages: 1. Formatting data into the correct shape for the pipeline 2. Running the pipeline to perform data checks, transformations, data processing and stage 1 analysis for meQTLs, EWAS and GWAS. This is currently partitioned into 15 modules, and after running each module the summary level results are checked and uploaded to a SFTP server in Bristol. 3. Running stage 2 meQTL analysis, whereby the pooled associations from all cohorts are retested in each cohort. 
Type Of Material Data handling & control 
Year Produced 2015 
Provided To Others? Yes  
Impact We have already recruited 30+ cohorts around the world and a sample size of more than 25,000 samples. Using the repository, all samples will be processed in a harmonized way. Through meta-analysis of summary statistics across all contributing cohorts, we have the potential to find many more trans methQTLs and explain more of the genetic variation underlying methylation variation than any study so far. 
URL https://github.com/MRCIEU/godmc
 
Title MR-Base 
Description MR-base is a database and analytical platform for Mendelian randomization being developed by the MRC Integrative Epidemiology Unit at the University of Bristol. 
Type Of Material Data analysis technique 
Year Produced 2016 
Provided To Others? Yes  
Impact Gibran Hemani, Jie Zheng, Kaitlin H Wade, Charles Laurin, Benjamin Elsworth, Stephen Burgess, Jack Bowden, Ryan Langdon, Vanessa Tan, James Yarmolinsky, Hashem A. Shihab, Nicholas Timpson, David M Evans, Caroline Relton, Richard M Martin, George Davey Smith, Tom R Gaunt, Philip C Haycock, The MR-Base Collaboration. MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations. bioRxiv. doi: https://doi.org/10.1101/078972 The Telomeres Mendelian Randomization Collaboration. Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol. Published online February 23, 2017. doi:10.1001/jamaoncol.2016.5945 
URL http://www.mrbase.org/
 
Title Meffil 
Description It is an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. 
Type Of Material Computer model/algorithm 
Year Produced 2015 
Provided To Others? Yes  
Impact To meet the challenges of processing an ever-increasing volume of methylation data, analysis pipelines must be easy to use, efficient, flexible, and able to seamlessly detect and handle technical artifacts. We have developed a new R package called meffil - efficient algorithms for analyzing DNA methylation - which meet these requirements. Meffil provides quality control reports,  normalizes large-scale datasets and include an analysis pipeline for epigenome-wide association studies. Different datasets in physically different locations can be normalized together without sharing original raw data using a minimum of information. The package has been tested on a dataset of ~5000 samples and will be used to process all ~30 datasets of the Genetics of DNA Methylation Consortium . 
URL https://github.com/perishky/meffil
 
Description ALPHABET 
Organisation University College Dublin
Department School of Public Health, Physiotherapy and Population Science
Country Ireland 
Sector Academic/University 
PI Contribution I am a co-investigator on a ERA-HDHL (BBSRC) collaborative research project on the influence of early life nutrition on offspring health led by UCD. Our contribution includes collating multi-centre epigenetic data, running epigenome-wide association studies, meta-analyses and causal analysis methods.
Collaborator Contribution The partners in this collaboration contribute data from various large birth cohort studies and expertise in nutrition and other clinical disciplines
Impact No outputs to report
Start Year 2017
 
Description Alcohol_exposure 
Organisation University of Toronto
Department Baycrest Centre for Geriatric Care
Country Canada 
Sector Hospitals 
PI Contribution joint analysis of ALSPAC (epigenetic) data and imaging phenotypes obtained by Toronto group
Collaborator Contribution imaging phenotypes obtained by Toronto group
Impact No output yet, but expected in 2017
Start Year 2016
 
Description Biogen Idec 
Organisation Biogen Idec
Department MR and Epigenetics Industry Translation
Country United Kingdom 
Sector Private 
PI Contribution We have hosted and visited Biogen Idec to pursue collaborative links around discovery science in epigenetics.
Collaborator Contribution Invitation to contribute to a Genomics Workshop at Biogen Idec and liaison regarding future collaboration
Impact A collaborative agreement is being formulated.
Start Year 2013
 
Description Bissau-vaccination 
Organisation The Statens Serum Institute (SSI)
Country Denmark 
Sector Public 
PI Contribution IEU processed and analysed epigenetic samples, provided by collaboration
Collaborator Contribution samples provided by collaboration
Impact No output yet, but expected in 2017
Start Year 2016
 
Description Columbia University, NY 
Organisation Columbia University
Department Mental Health, Causal Epidemiology
Country United States 
Sector Academic/University 
PI Contribution My research team interact with Prof Ezra Susser at Columbia University on various aspects of epigenetics research. This involves face-to-face meetings, teleconferences and email correspondence.
Collaborator Contribution Prof Susser brings expertise in epidemiology and psychiatry.
Impact No specific outputs to record in this reporting period. Grant applications have been submitted but have not been successful.
Start Year 2013
 
Description Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation. 
Organisation National Institute of Environmental Health Sciences
Country United States 
Sector Academic/University 
PI Contribution Co-authored an invited review
Collaborator Contribution Co-authored an invited review
Impact Richmond RC and Joubert BR. Contrasting the effects of intr a-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation. Epigenomics 2017 Mar;9(3):351-367. doi: 10.2217/epi-2016-0135. Epub 2017 Feb 17.
Start Year 2016
 
Description Copenhagen University 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Hospitals 
PI Contribution We bring epigenetic epidemiology expertise. This collaboration is focused around the exploration of DNA methylation as an intermediate linking cigarette smoke exposure to a wide range of health outcomes.
Collaborator Contribution The collaborators bring access to and biosamples from their very large population based resources, namely the Copenhagen City Heart Study
Impact Manuscripts under submission and further papers are in preparation.
Start Year 2013
 
Description E4 Project and Epigenetics and Social Science Network Collaboration 
Organisation University of Bristol
Department Epigenetics and Social Science Network
Country United Kingdom 
Sector Academic/University 
PI Contribution The University of Bristol team brings expertise in epigenetic epidemiology, life course epidemiology, infrastructural epidemiology, clinical epidemiology, education, public engagement, access to large data sets, training provision and hosting of visiting researchers to this collaboration.
Collaborator Contribution A collaborative network of eight projects comprising of biological and social scientists from many disciplines to facilitate collaboration and communication within the epigenetics community.
Impact The network have contributed to joint meetings and there are research collaborations within the network supported by a joint website. Engagement activities involved in: Statistical approaches for epigenetics workshop Bristol, Epigenetics and Social Science Network (ESSN) website, Epigenetics and Social Science Network (ESSN) Launch event in Bristol.
Start Year 2016
 
Description ENIGMA -Anorexia 
Organisation University of Dresden
Country Germany 
Sector Academic/University 
PI Contribution analysis of imaging phenotype in anorexia
Collaborator Contribution analysis of imaging phenotype in anorexia
Impact No output yet, but expected in 2017
Start Year 2016
 
Description ESRC Biomarker Data Project Fellowship in Understanding Society - R Richmond 
Organisation University of Essex
Department Institute for Social and Economic Research, Essex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data analysis of Understanding Society data.
Collaborator Contribution Data provision for Understanding Society and mentorship.
Impact Rebecca Richmond was awarded an ESRC fellowship.
Start Year 2018
 
Description European Bioinformatics Institute 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution We bring epidemiological and causal analysis expertise to this collaboration as well as generating epigenomic data for use by colleagues at EBI.
Collaborator Contribution Bioinformatic expertise for the functional annotation of observed associations.
Impact EBI have been involved in ARIES and have more recently been closely involved in formulating large strategic funding applications. The outputs of this work are too early to report. This is a multi-disciplinary collaboration between epidemiologists and bioinformaticians.
Start Year 2013
 
Description GOYA Study Copenhagen 
Organisation Copenhagen University Hospital
Country Denmark 
Sector Hospitals 
PI Contribution We have generated epigenome-wide DNA methylation data on the GOYA cohort (a study of the offspring of extremely obese individuals) and have provided advice and analytical support in the use of these data.
Collaborator Contribution The provision of biological samples for epigenetic profiling as well as associated data for analysis. Our collaborators also facilitate the acquisition of ethical permission to use the data for new analyses.
Impact As a consequence of this collaboration GOYA is now part of the PACE study and features in various manuscripts that are currently in preparation led by my group.
Start Year 2013
 
Description GW4 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GW4 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GW4 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution The GW4 strategic alliance has established the GW4 Epigenetics Consortium which I instigated and brings complementary expertise from the 4 contributing Universitites together.We hosted a 2 day symposium and workshops and have subsequently secured and undertaken research activities around the use of CRISPR/Cas9 in epigenetics studies
Collaborator Contribution 2 day symposium and workshops. Epidemiology expertise.
Impact 2 day symposium and workshops. Further grant application to GW4 for research activities. This is a multi-disciplinary collaboration between epidemiologists, clinicians, experimental biologists, bioinformaticians and epigeneticists
Start Year 2014
 
Description GenR-ADHD 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution joint analysis of ALSPAC and GenR epigenetic data
Collaborator Contribution joint analysis of ALSPAC and GenR epigenetic data
Impact No output yet, but expected in 2017
Start Year 2016
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation Austrian Academy of Sciences
Department Research Centre for Molecular Medicine
Country Austria 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description GoDMC: Genetics of DNA Methylation Consortium 
Organisation University of Exeter
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution We are currently leading the GoDMC consortium. The GoDMC consortium consists of five core groups (IEU, Kings College London, University of Exeter, Leiden University Medical Centre and Austrian Academy of Sciences) and we recruited 30+ cohorts to contribute to the GoDMC consortium. Matt Suderman and Josine Min have developed an R package "Efficient algorithms for analyzing DNA methylation data" (meffil) (https://github.com/perishky/meffil) which is designed to conduct quality control and normalization of large-scale methylation datasets. Meffil also conducts epigenome wide association studies (EWAS) using four different methods. In addition, Josine Min and Gibran Hemani have written a pipeline on github, which automates all analyses. Participating cohorts will download the pipeline and will follow instructions to run the pipeline.
Collaborator Contribution We have monthly calls with the core team to discuss analyses and there are weekly calls between analysts for technical issues. The core analysts are testing the pipeline on their cohorts externally.
Impact Software development: R package meffil and github pipeline for GoDMC analyses Disciplines: Genetic epidemiology, epigenetic epidemiology
Start Year 2013
 
Description HUNT Sleep collaboration - R Richmond 
Organisation Norwegian University of Science and Technology (NTNU)
Country Norway 
Sector Academic/University 
PI Contribution Rebecca Richmond developed an analysis plan for running parallel analysis in UK Biobank and HUNT.
Collaborator Contribution Developed an analysis plan for running parallel analysis in UK Biobank and HUNT.
Impact In progress
Start Year 2017
 
Description Harvard School of Public Health 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Epigenetic epidemiology expertise
Collaborator Contribution Social epidemiology and social determinants of health. This collaboration, primarily with Prof Nancy Krieger, involves collaboration on biosocial epigenetics research. Prof Krieger leads a unique study on racial and economic discrimination on which we are planning epigenetic studies.
Impact Collaborators are involved in Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Preparations are in progress for an NIH grant submission.
Start Year 2014
 
Description IARC 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Public 
PI Contribution This long-standing collaboration (consolidated by a short sabbatical in 2008) led to a large scale NIH funded biomarker study which is ongoing. More recently, a CRUK programme in integrative cancer epidemiology has been awarded on which I am Co-PI. I bring programme leadership and epigenetic epidemiology and causal analysis expertise.
Collaborator Contribution Genetic epidemiology and access to large multi-national consortia.
Impact P Brennan, M Johansson, CL Relton, PM Ueland, P Vineis et al. One carbon metabolism biomarkers and lung cancer risk. Sep 2011-Aug 2016 NIH/NCI R01 [$5,060,000] Co-I Martin RM (Co-PI), Relton CL (Co-PI) et al. Reducing the burden of cancer: Causal risk factors, mechanistic targets and predictive biomarkers. £4.15M. CRUK Programme. Jun 2015 - May 2020. Johansson M, Fanidi A, Muller D, Bassett J, Midttun Ø, Vollset SE, Travis R, Palli D, Mattiello A, Sieri S, Trichopoulou A, Lagiou P, Trichopoulos D, Ljungberg B, Hallmans G, Weiderpass E, Skeie G, González C, Dorronsoro M, Peeters P, Bueno-de-Mesquita HB, Ros M, Boutron-Ruault MC, Fagherazzi G, Clavel-Chapelon F, Sánchez MJ, Barricarte Gurea A, Navarro C, Quirós JR, Overvad K, Tjønneland A, Aleksandrova K, Vineis P, Gunter M, Giles G, Relton C, Riboli E, Boeing H, Ueland PM, Severi G, Brennan P. Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. J Natl Cancer Inst 2014;106(12):pii. PMID: 25376861 Fanidi A, Relton CL, Ueland PM, Midtun Ø, Vollset SE, Travis RC, Trichopoulou A, Lagiou P, Trichopoulos D, Bueno-de-Mesquita HB, Ros M, Boeing H, Tumino R, Panico S, Palli D, Sieri S, Vineis P, Sánchez MJ, Huerta JM, Barricarte Gurrea A, Luján-Barroso L, Quirós JR, Tjønneland A, Halkjær J, Boutron-Ruault MC, Clavel-Chapelon F, Cadeau C, Weiderpass E, Johansson M, Riboli E, Brennan P, Johansson M. A prospective study of one-carbon metabolism biomarkers and cancer of the head, neck and oesophagus. Int J Cancer 2014;136(4):915-27. PMID: 24975698 Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P. Hypomethylation of smoking-related gene is associated with future lung cancer in four prospective cohorts. Nat Commun 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192. PMID: 26667048 Further manuscripts are under review.
Start Year 2007
 
Description Imperial College London - Environmental Epigenetics 
Organisation Imperial College London
Department National Heart & Lung Institute (NHLI)
Country United Kingdom 
Sector Academic/University 
PI Contribution My team collaborates with this group to replicate and meta-analyse epigenetic epidemiology study findings. I have acted as a PhD progress panel member for one candidate and a PhD external examiner for another candidate.
Collaborator Contribution This group collaborates with us to replicate and meta-analyse epigenetic epidemiology study findings.
Impact Demetriou CA, van Veldhoven K, Relton C, Stringhini S, Kyriacou K, Vineis P. Biological embedding of early life exposures and disease risk in humans: a role for DNA methylation. Eur J Clin Invest. 2015 doi:10.111/eci.12406 PMID:25645488. Fasanelli F, Baglietto L, Ponzi E, Guida F, Campanella G, Johansson M, Grankvist K, Johansson M, Assumma MB, Naccarati A, Chadeau-Hyam M, Ala U, Faltus C, Kaaks R, Risch A, De Stavola B, Hodge A, Giles GG, Southey MC, Relton CL, Haycock PC, Lund E, Polidoro S, Sandanger TM, Severi G, Vineis P. Hypomethylation of smoking-related gene is associated with future lung cancer in four prospective cohorts. Nat Commun 2015 Dec 15;6:10192. doi: 10.1038/ncomms10192. PMID: 26667048 Further publications are in preparation.
Start Year 2013
 
Description Institute of Metabolic Science, Cambridge 
Organisation University of Cambridge
Department Institute of Metabolic Science (IMS)
Country United Kingdom 
Sector Academic/University 
PI Contribution This long-standing collaboration focuses on complementary approaches to the developmental origins of adult disease with the group of Prof Sue Ozanne. My team bring epidemiological expertise, causal analysis methods, population epigenetics and leadership of the ARIES project.
Collaborator Contribution Dr Sue Ozanne brings expertise in animal model studies.
Impact Joint publication; Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM, Davey Smith G. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol 2015;44(4):1181-90. PMID: 25991711
Start Year 2013
 
Description KCL - Epigenetics 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We bring epidemiological expertise and expertise in causal analysis methodology to a series of collaborations. We have collaborated on joint research proposals which have been successful.
Collaborator Contribution Our collaborators bring the following expertise; Dr Helen Fisher: Social Science and Psychiatry Dr Ted Barker: Conduct problems Dr Jordana Bell; Twin studies
Impact Dr Fisher was awarded a MQ Fellowship on which I act as a sponsor. We are Co-Investigators on a recently awarded ESRC grant; Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513. Drs Bell and Fisher is a collaborator on a further ESRC grant of which I am PI; Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. We have collaborated with Dr Barker on a NIH-funded project; E Barker, J Mill, G Davey Smith, B Maughan, CL Relton. Epigenetic pathways to conduct problem trajectories: the role of prenatal and postnatal environmental risk exposures. Jan 2012-Dec 2016 NIH/NICHD [£1,100,000] Co-I. With the following outputs; Cecil CAM, Lysenko LJ, Jaffee SR, Pingault J-B, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED. Environmental risk, oxytocin receptor gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study. Mol Psychiatry 2014;19(10):1071-7. PMID: 25199917 Rijlaarsdam J, Pappa I, Walton E, Bakermans-Kranenburg MJ, Mileva-Seitz VR, Rippe RC, Roza SJ, Jaddoe VW, Verhulst FC, Felix JF, Cecil CA, Relton CL, Gaunt TR, McArdle W, Mill J, Barker ED, Tiemeier H, van Ijzendoom MH. An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication. Epigenetics 2016. In Press. Further papers are under review. Dr Bell is a co-PI of the Genetics of DNA Methylation Consortium (GoDMC).
Start Year 2013
 
Description Leiden University Medical Centre 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution We have collaborated on the ARIES study which included the profiling of DNA methylation in autopsy samples provided by Dr Bas Heijman's group at LUMC in our Bristol labs. We have cleaned and QC'd the data and contributed to data analysis. We also work closely with this group in leading the Genetics of DNA Methylation Consortium (GoDMC).
Collaborator Contribution Our collaborators provided autopsy biological samples and associated data. They have led the data analysis and preparation of findings for publication.
Impact A Data Resource Profile has been published; Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM, Davey Smith G. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol 2015;44(4):1181-90. PMID: 25991711 A further publication describing methylation profiles in different tissues is in preparation.
Start Year 2013
 
Description Longitudinal_epi_GenR 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution joint analysis of ALSPAC and GenR epigenetic data
Collaborator Contribution joint analysis of ALSPAC and GenR epigenetic data
Impact No output yet, but expected in 2017
Start Year 2016
 
Description MRC Lifecourse Epidemiology Unit - Southampton 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Public 
PI Contribution I chair the Steering Group of a MRC-Newton Fund UK-India & Africa Project; Epigenetic mechanisms linking maternal pre-conceptional micronutrient supplementation with offspring health in India and The Gambia
Collaborator Contribution Opportunity to contribute to a multi-national epigenetics project and share our knowledge and expertise in epigenetic epidemiology and causal analysis methods
Impact First Steering Group meeting, held in Hyderabad Feb 2016.
Start Year 2013
 
Description MRC The Gambia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia 
Sector Public 
PI Contribution Collaboration in epigenetics research. Co-investigator on recently funded award to establish a W African Bioresource in nutritional genetics and epigenetics.
Collaborator Contribution Myself and members of my team have committed to helping our colleagues at the MRC Gambia Unit establish a bioresource to support molecular epidemiology research in the future. This will involve researcher exchanges,workshops and training in Bristol and the provision of ongoing support and capacity building in The Gambia.
Impact No outputs to report as yet
Start Year 2018
 
Description MRC Unit for LIfelong Health and Ageing 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution We bring epigenetics expertise to this collaboration. The NSHD (MRC 1946 Study) complements the Bristol-based ALSPAC study. I am a member of the NSHD Biosample Access Committee
Collaborator Contribution We collaborate on a variety of studies including epigenetics of the menopausal transition and the role of biosocial factors in epigenetic variation. The NSHD is a collaborating cohort on a recently awarded ESRC project grant.
Impact Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513.
Start Year 2013
 
Description Newcastle University - Diabetes 
Organisation Newcastle University
Department Diabetes Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution Part of my MRC IEU programme of work involves the investigation of the role of DNA methylation in Type 2 diabetes. This long-standing collaboration with colleagues at Newcastle University brings our genetic and epigenetic epidemiological expertise to the collaboration
Collaborator Contribution Our collaborators (group of Prof Mark Walker) bring cell culture expertise relevant to function analysis of epigenetic variation as well as facilitating access to large pan-European cohort studies such as RISC.
Impact This group is a collaborator on a postdoctoral fellowship for a member of my group (Dr Hannah Elliott). This is a multi-disciplinary collaboration between clinical diabetologists and epidemiologists.
Start Year 2013
 
Description Newcastle University - iPSC Biology 
Organisation Newcastle University
Department Institute of Genetic Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We have been actively pursuing the development of a population-based resource of iPSC lines utilising existing lymphoblastoid cell lines (LCLs). We bring population-based resources to this collaboration.
Collaborator Contribution Our collaborators bring valuable stem cell biology expertise and have undertaken proof of principle studies on our samples to demonstrate that iPSC can be generated from LCLs.
Impact We have prepared collaborative funding applications but none as yet have been successful. This is a multi-disciplinary collaboration between stem cell biologists and epidemiologists.
Start Year 2013
 
Description Newcastle University- Institute of Genetic Medicine 
Organisation Newcastle University
Department Institute of Genetic Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution My team brings epidemiological and epigenetics expertise to this collaboration. I co-supervise 2 PhD students hosted at Newcastle University. During this reporting period I have also collaborated on a range of projects.
Collaborator Contribution Clinical genetics expertise.
Impact Jessica Timms, PhD "Influence of early environmental exposures on epigenetic markers of leukaemia in infants" Keith Wu, PhD "Investigating the role of epigenetics in the control of inflammatory skin disease" Timms JA, Relton CL, Rankin J, Strathdee G, McKay JA. DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukaemia. Epigenomics 2016;8(4):519-36. doi: 10.2217/epi-2015-0011. Van Otterdijk SD, Norden J, Dickinson AM, Pearce MS, Relton CL, Mathers JC, Strathdee G. Aberrations in DNA methylation are detectable during remission of acute lymphoblastic leukaemia and predict patient outcome. Epigenomics 2015;7(1);35-45. doi:10.2214/epi.14.78. PMID: 25687464. Sitarz K, Elliott HR, Karaman BS, Relton CL, Chinnery PF, Horvath R. Valproic acid triggers increased mitochondrial biogenesis in POLG deficient fibroblasts. Mol Genet Metab 2014;112(1):57-63. PMID: 24725338
Start Year 2013
 
Description Norwegian Institute of Public Health 
Organisation Norwegian Institute of Public Health
Country Norway 
Sector Academic/University 
PI Contribution We bring epigenetic epidemiology expertise to this collaboration.
Collaborator Contribution Access to a very large birth cohort as well as epidemiological and clincial expertise.
Impact Inclusion in the PACE consortium. Training and exchange visits. Preparation of joint grant applications. Joint research publications e.g. "25-hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC) The Journal of Steroid Biochemistry and Molecular Biology Suderman M, Stene LC, Bohlin J, Page CM, Holvik K, Parr CL, Magnus MC, Håberg Siri E, Joubert BR, Wu MC, London SJ, Relton C, Nystad W
Start Year 2013
 
Description Pfizer 
Organisation Pfizer Inc
Department Epigenetics
Country United States 
Sector Private 
PI Contribution I was PI of a collaborative award made by Pfizer to undertake a research project in my group.Interaction continues following the completion of this work
Collaborator Contribution Pfizer funded a 2 year research project hosted at the University of Bristol and liaised throughout regarding the prioritization and delivery of analyses undertaken. A financial contribution of £175,000 was made by Pfizer.
Impact Project reports delivered to Pfizer. Peer reviewed scientific publications in preparation.
Start Year 2013
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Center for Environmental Research and Children's Health
Department The CHAMACOS Study
Country United States 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Columbia Center for Children's Environmental Health
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Association for Research on Learning and Instruction (EARLI)
Country Belgium 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation European Huntington's Disease Network (Euro-HD)
Country Germany 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU)
Department International Climate Initiative (ICI)
Country Germany 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Finnish Birth Cohort
Country Finland 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GECKO Drenthe Birth Cohort
Country Netherlands 
Sector Hospitals 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenExp
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation GenR
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Glyndwr University
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Government of Canada
Department Aboriginal Affairs and Northern Development
Country Canada 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation ITS United Kingdom
Country United Kingdom 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Inmarsat
Country United Kingdom 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation MTT Ltd Machine Tools Technologies
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Heart, Lung, and Blood Institute (NHLBI)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Environmental Health Sciences
Department Norway Facial Clefts Study (NCL)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation National Institute of Standards & Technology (NIST)
Country United States 
Sector Public 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation New Hampshire Birth Cohort Study
Country United States 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation PRISMA ONG
Country Peru 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Progressive Energy Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Project Viva
Country United States 
Sector Charity/Non Profit 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation Rutherford Appleton Laboratory
Department Space Science and Technology Department
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Bristol
Department Avon Longitudinal Study of Parents and Children (ALSPAC)
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Cambridge
Department PomBase
Country United Kingdom 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation University of Western Australia
Department Raine Medical Research Foundation
Country Australia 
Sector Academic/University 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Pregnancy and Childhood Epigenetics (PACE) 
Organisation VCE Mobile & Personal Comm Ltd
Country United Kingdom 
Sector Private 
PI Contribution PACE projects with contributions from our research team. "Leading" a project involves devising the study, writing and distributing the analysis plan, running analyses in ALSPAC/GOYA, collecting results from other participating cohorts, running the meta-analysis, interpreting the results, liaising with other cohorts about the results and preparing the manuscript. "Contributing results" to a project involves providing feedback on an analysis plan, running the analysis in ALSPAC/GOYA, providing results to the meta-analysis centre, discussing interpretation of the results with the project leaders and commenting on the manuscript.: Projects led/co-led by UoB: Maternal smoking; led by Bonnie Joubert (MoBa) and others including Rebecca Richmond (UoB) Maternal BMI; led by Gemma Sharp (UoB) and Janine Felix (Generation R). Childhood BMI; led by Janine Felix (Generation R) and others including Gemma Sharp (UoB) Pre-eclampsia/Maternal hypertension; led by Nabila Kazmi (UoB) and Marie-France Hivert (Harvard) Eczema; led by Lavinia Paternoster (UoB) and Generation R Lung Function; led by UoB (Kim Burrows, John Henderson) and Generation R Collaboration between PACE and CHARGE - Prenatal alcohol exposure and cord blood DNA methylation; led by Luisa Zuccolo, Gemma Sharp (UoB) and Janine Felix (Generation R). Chunyu Lui (NIH) is leading the CHARGE+ consortium meta-analysis of own alcohol exposure/own DNA methylation and we are planning a reciprocal look-up of results. CHARGE+ is a large consortium initially formed to facilitate genome-wide association study meta-analyses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. CHARGE+ now additionally facilitate epigenome-wide meta-analyses. Projects with contributions from UoB: Maternal thyroid function; led by Generation R, with input from Pete Taylor (UoB). Plans for a follow-up paper led by UoB (Gemma Sharp and Tamsin Sharp). Birth weight; led by GECKO, with contribution of results from Gemma Sharp (UoB) Asthma/wheeze; led by MoBa, with contribution of results from Kim Burrows (UoB) and Ryan Arathimos (UoB) Otitis Media; led by Generation R with contribution of results from Gemma Sharp (UoB)
Collaborator Contribution Aside from the projects listed above, some partners have contributed to an air pollution project that ALSPAC/GOYA could not participate in due to data-availability. PACE teleconference calls are organised and chaired by Stephanie London (MoBa/NIEHS).
Impact Joubert, BR, et al DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31.
Start Year 2014
 
Description Public Health Foundation India 
Organisation Public Health Foundation of India
Country India 
Sector Public 
PI Contribution I supervise a PHFI Postdoctoral Fellow, Dr Gagandeep Kaur Walia. I regularly host this fellow in my research group and provide ad hoc research support and advice to her.
Collaborator Contribution Cultural diversity and the opportunity to collaborate with Indian cohort studies.
Impact Kaur Walia G. Public Health Foundation of India-UK Joint Fellowship. Jul 2015-Jun2017. Supervisor.
Start Year 2013
 
Description Sanofi Aventis 
Organisation Sanofi
Department Aventis
Country France 
Sector Private 
PI Contribution Epigenetics expertise and functional annotation of target loci identified by the collaborators
Collaborator Contribution Direction in terms of target prioritization as well as financial support for a postdoctoral assistant.
Impact An Annotation pipeline has been developed to provide information on potential targets.
Start Year 2015
 
Description School of Computing Science, Newcastle 
Organisation Newcastle University
Department School of Computing Science
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration formed a central part of the development of infomatics systems for the ARIES (ALSPAC) project. Our role in the collaboration was as project leaders and to provide data and design guidance for the web browser that was ultimately produced for this project.
Collaborator Contribution Prof Anil Wipat's team provided expertise in data integration and helped to design and construct the ARIES-Explorer web interface.
Impact A description of the resource has been published; Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM, Davey Smith G. Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol 2015;44(4):1181-90. PMID: 25991711 A web-interface to browse summary data (see above URL)
Start Year 2013
 
Description UCL - Epigenetics 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution My team brings epigenetic epidemiology and causal analysis expertise to this series of collaborations. We lead a range of research on the SABRE project, the PIs of which are based at UCL.
Collaborator Contribution Prof Nish Chaturvedi: PI of the SABRE project brings epidemiology expertise and access to data on this cohort. Prof Chris Power: Co-PI of the 1958 Birth Cohort which is involved in our biosocial epigenetics research activities. Dr Gabriella Conti: an economist who collaborates on our biosocial epigenetics research. Dr Alun Hughes: A cardiovascular physician who collaborates on cardiovascular epigenetics research on SABRE, ALSPAC and other cohorts. Profs Hughes and Chaturvedi also provide mentorship for Dr Hannah Elliott (a postdoctoral fellow in my group) who works with SABRE data.
Impact A Hughes, G Davey Smith, M Charakida, N Chaturvedi, JE Deanfield, M Hickman, L Howe, DA Lawlor, C Relton. Study of emerging adulthood and cardiometabolic health in ALSPAC: the influence of growth and other exposures (SEA CHANGE). British Heart Foundation (CS/15/6/31468). 1st July 2015 for 5 years. £999,049. Elliott HR, Tillin T, McArdle WL, Ho K, Duggirala A, Frayling TM, Davey Smith G, Hughes AD, Chaturvedi N, Relton CL. Differences in smoking associated DNA methylation patterns in South Asians and Europeans. Clin Epigenetics. 2014; 6(1):4. PMID: 24485148 Dr Conti and Prof Power collaborate on the following projects: Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460. Howe L, Relton CL (Co-I), Davey Smith G, Gaunt T, Suderman M, Simpkin A, Davies N, Shihab H, Marioni R, Hardy R, Wong C, Fisher H, John R, Jerrim J, Deary I, Mill J. Interpreting epigenetic signatures in studies of early life adversity (InterSTELA) ESRC. £195,513. This is a multi-disciplinary collaboration with multiple disciplines involved.
Start Year 2013
 
Description UCLA - Epigenetics 
Organisation University of California
Country United States 
Sector Academic/University 
PI Contribution Epigenetic epidemiology expertise and access to large data sets
Collaborator Contribution Epigenetic clock expertise
Impact Simpkin AJ, Hemani G, Suderman M, Gaunt TR, Lyttleton O, McArdle W, Ring SM, Sharp GC, Tilling K, Horvath S, Kunze S, Peters A, Waldenberger M, Ward-Caviness C, Nohr EA, Sorenson TI, Relton CL, Davey Smith G. Prenatal and early life influences on epigenetic age in children: A study of mother-offspring pairs from two cohort studies. Hum Mol Genet Nov 5 2015. PMID 26546615 Additional manuscripts are in preparation.
Start Year 2015
 
Description UFPel 
Organisation Federal University of Pelotas (UFPel)
Country Brazil 
Sector Academic/University 
PI Contribution Epigenetic epidemiology expertise. Training provision (hosting of visiting researchers and delivery of training in Brazil) Contribution to co-supervision of a PhD student
Collaborator Contribution Access to unique Brazilian birth cohorts. Maternal and perinatal epidemiology
Impact Relton CL, Hartwig FP Davey Smith G. From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive. Int J Epidemiol 2015 44 (4): 1083-1093. doi: 10.1093/ije/dyv198 Genomics, Epigenomics and Causal Inference in Population Health, Federal University of Pelotas, Brazil, March 2015
Start Year 2013
 
Description UK Biobank Sleep Working Group - R Richmond 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Rebecca Richmond participated in conference calls and in writing team of manuscripts.
Collaborator Contribution Provision of data generated from research to our team for secondary analysis.
Impact In progress.
Start Year 2017
 
Description UK Biobank Sleep Working Group - R Richmond 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Rebecca Richmond participated in conference calls and in writing team of manuscripts.
Collaborator Contribution Provision of data generated from research to our team for secondary analysis.
Impact In progress.
Start Year 2017
 
Description UK Biobank Sleep Working Group - R Richmond 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Rebecca Richmond participated in conference calls and in writing team of manuscripts.
Collaborator Contribution Provision of data generated from research to our team for secondary analysis.
Impact In progress.
Start Year 2017
 
Description University College London - Epigenetics 
Organisation European Commission
Department Seventh Framework Programme (FP7)
Country European Union (EU) 
Sector Public 
PI Contribution This ongoing collaboration is established with the group of Prof Stephan Beck. Collaboration involves exchange of advice and views on various research projects. We have provided training and networking opportunities for members of the Beck group.
Collaborator Contribution Provision and seeking of advice and views on scientific matters pertinent to epigenetics. Prof Beck served on the advisory board of the ARIES project. Networking and training opportunities have been provided by this group.
Impact Through this collaboration I am now a member of a GEL GeCIP with Prof Beck and other colleagues.
Start Year 2013
 
Description University of Alberta 
Organisation University of Alberta
Country Canada 
Sector Academic/University 
PI Contribution I co-supervise a PhD student who spent part of her studentship in my group in the UK and is completing her PhD in Edmonton. I provide epigenetic epidemiology expertise and access to ALSPAC data.
Collaborator Contribution Co-supervision of PhD. Perinatal epidemiology expertise.
Impact The studentship is almost complete and the main output will be a thesis. The extended duration has been due to maternity leave during the studentship.
Start Year 2011
 
Description University of Cambridge - BLUEPRINT 
Organisation European Commission
Department Seventh Framework Programme (FP7)
Country European Union (EU) 
Sector Public 
PI Contribution Initial collaboration for MRC IEU
Collaborator Contribution The BLUEPRINT consortium has generated valuable data on epigenetic signatures in haematological cell types. The information generated is now publicly available and we have not therefore pursued any direct collaboration with this group.
Impact No outputs or outcomes to report
Start Year 2013
 
Description University of Colorado, Denver 
Organisation University of Colorado Denver
Country United States 
Sector Academic/University 
PI Contribution I am a co-opted co-investigator and member of the scientific advisory group for this large Bill & Melinda Gates Foundation project called Women First. I act in the capacity as an academic mentor to Dr Sarah Borengasser who works on this project and has undertaken visits and training with my group. I have initiated collaborations with Prof Dana Dabelea on related research interests, specifically bringing epigenetic epidemiology and causal analysis methods expertise.
Collaborator Contribution Opportunity for involvement in a major international maternal nutrition trial and associated research activities.
Impact Travel awards from US funders to Dr Sarah Borengasser. Bi-annual Scientific Advisory Group meetings.
Start Year 2014
 
Description University of Dundee 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Epigenetic epidemiology and causal analysis expertise
Collaborator Contribution Paediatric dermatology expertise
Impact Dr Brown was awarded a Wellcome Trust Intermediate Clinical Fellowship and I collaborate with her on this award.
Start Year 2013
 
Description University of Exeter Medical School 
Organisation University of Exeter
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution My team collaborates with genetic epidemiologists and epigeneticists at this institution. I am a collaborator on the Wellcome Trust Sir Henry Dale Felowship of Dr Rachel Freathy. I also bring epidemiological expertise to our collaboration with Prof Jonathan Mill, with whom we have obtained joint funding.
Collaborator Contribution Dr Freathy undertakes large scale genetic epidemiology and utilises samples from our studies. Prof Mill brings epigenetic expertise as well as tissue specific epigenetic studies. We collaborate with Prof Mills in the leadership of the genetics of DNA methylation Consortium (GoDMC).
Impact GW4 Initiator grant to establish a GW Epigenetics Consortium GW4 Accelerator grant (CRISPR/Cas) to pilot gene editing on epigenetic loci. Prof Mill is a co-PI on the Genetics of DNA Methylation Consortium
Start Year 2013
 
Description University of Queensland 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution Epigenetic epidemiology and causal analysis expertise
Collaborator Contribution Quantitative genetics expertise
Impact Evans D (PI), Relton C, Davey Smith G Powell J. Novel ways of utilizing genome-wide DNA methylation data from peripheral blood samples in genetic epidemiology. ~£400k. NHMRC. Jan 2015 - Dec 2017. Involvement in recently awarded project: Relton CL (PI), Davey Smith G, Power C, Deary I, Davies N, Tilling K, Gaunt T, Munafo M, Windmeijer F, Visscher P, Marioni R, Ingram N, van den Berg G, Murtagh M. Epigenetics: Environment, Embodiment and Equality (E4). ESRC. £667,460.
Start Year 2013
 
Description University of Western Australia - Raine 
Organisation University of Western Australia
Department Raine Medical Research Foundation
Country Australia 
Sector Academic/University 
PI Contribution Collaboration with the Raine cohort at UWA had been continued through involvement in the PACE consortium. This involves meta-analysis of epigenome-wide association studies that we are leading.
Collaborator Contribution Participation in PACE meta-analyses.
Impact This study is now part of the PACE and GoDMC consortia so is listed under these initiatives
Start Year 2013
 
Title EWAS Catalog 
Description This webtool/application has curated all published epigenome-wide association studies (EWAS) (using the Illumina BeadChip platform) and incorporated them in to a searchable data base. This allows the user to locate any variable methylation probes they may be interested in in a similar way to the GWAS catalog for genetic variants. It provides a centralised repository and search tool for any investigator interested in EWAS. 
Type Of Technology Webtool/Application 
Year Produced 2018 
Open Source License? Yes  
Impact The web application has just been released. It should have considerable impact across the research community as a browsing facility for all documented EWAS that appear in the published literature. 
URL http://www.ewascatalog.org
 
Description BBC Radio 4 interview - Caroline Relton 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Caroline Relton was interviewed on BBC radio 4 show 'Start the week' on Monday 13th November 2017. Professor Relton discusses her research into how stress and other environmental factors can be passed down through generations, affecting our genetic make-up. This interview rasied the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b09drjb7
 
Description Collaborative research visit to Bristol - Ulster University 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Three members from Ulster University (Professor Colum Walsh, Rachelle Irwin and Sarah-Jayne Mackin) visited our research unit in Bristol for a collaborative research visit. We all presented our work and looked for synergy within the projects in order for us to share research strategies for the future.
Year(s) Of Engagement Activity 2016
 
Description Course on genetic and epigenetic epidemiology for CLAHRC (Gemma Sharp) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact We helped design and run a workshop to provide an introduction to genetics and epigenetics for public health to CLAHRC and local policy makers, including some employed by Bristol City Council.
Year(s) Of Engagement Activity 2016
 
Description DATA MINE: interactive festival science installation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Hundreds of attendees at the Green Man music festival attended our "DATA MINE , an interactive art installation inspired by genetic epidemiology." The goal of the installation was to spread awareness of and interest in the process of scientific research, the structure of the human genome and how genes control biological phenotypes. While attendees of all ages were welcome to (and did!) participate, the installation was focussed at children and their parents. Discussion between researchers and attendees was sparked and many reported increased interest and knowledge of our research area .
Year(s) Of Engagement Activity 2016
 
Description Education in our genes 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This one day workshop was aimed at both social and biomedical scientists to present current developments around the application of genetic and epigenetic data in relation the educational attainment and related characteristics
Year(s) Of Engagement Activity 2017
 
Description Epigenetic Clock Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A one day workshop was held to present and discuss approaches to research using the epigenetic clock as a biomarker of biological age.
Year(s) Of Engagement Activity 2017
 
Description Epigenetic Epidemiology, Wengen Winter School in Epidemiology, Wengen, Switzerland 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This short course involved lectures,group work and discussion. It helped the course members to have a better understanding of epigenetic epidemiology and will prompt them to incorporate this in to their future research.
Year(s) Of Engagement Activity 2016
URL http://www.epi-winterschool.org/
 
Description Epigenetics and Social Science Network (ESSN) Launch event in Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This event was to launch the ESRC and BBSRC Epigenetics Initiative, which has subsequently became known as the Epigenetics and Social Science Network (ESSN). Approximately 54 people attended the launch event, including academics in a variety of fields, as well as ESRC and BBSRC representatives in order to share information about the 8 projects which make up the network. All eight research projects were presented, and discussion followed regarding how the ESRC and BBSRC epigenetics community might provide mutual support including through data sharing, a shared calendar of events, resource sharing, networking opportunities for early career researchers and effective communication within the group. Following the event research collaborations have been established and a network website has been produced which allows the group to have a central method of communication.
Year(s) Of Engagement Activity 2015
URL http://www.bristol.ac.uk/integrative-epidemiology/epigenetics-social-science-network/news/2016/epige...
 
Description Epigenetics: Environment, Embodiment and Equality seminar Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Rebecca Richmond from the E4 project team gave a seminar for the Unit of Biocultural Variation and Obesity at the University of Oxford. The seminar sparked a lot of discussion as the researchers in this group were predominantly anthropologists rather than biologists so they knew relatively little beforehand about the intricacies of measuring epigenetic changes in large studies and the types of quantitative methods being applied. Collaborations are being developed with the seminar organiser and other attendees and the presentation allowed them to gain more of an insight into the type of research undertaken.
Year(s) Of Engagement Activity 2016
URL http://user37685.vs.easily.co.uk/wp/?page_id=223
 
Description Epigenomics for Epidemiologists, Wengen Winter School in Epidemiology, Wengen, Switzerland 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This short course involved lectures, group tasks and discussion. The course stimulated subsequent email exchanges and the development of new epigenetic epidemiology projects.
Year(s) Of Engagement Activity 2015
URL http://www.epi-winterschool.org/
 
Description Epigenomics of Common Disease Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Session Chair: Epigenomics of Common Disease Conference, Cambridge, November 2013

Informed discussion and debate.
Year(s) Of Engagement Activity 2013
 
Description Fun Palaces event planning - Rebecca Richmond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rebecca Richmond (ICEP Researcher) helped to organise a public engagement event relating to her e-cigarette study which was at Fun Palaces in Bristol in October 2017. Fun Palaces initiative is where community organisations lead events to connect public members with scientific research through creative interests or hobbies and expertise that may sit within those communities. The event allowed knowledge exchange between researchers and the public, informing about the demographic of e-cigarette use.
Year(s) Of Engagement Activity 2017
 
Description Gene Genies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Gene Genies is an activity stall presented at Green Man music festival and the Born in Bradford cohort festival. It is designed to show how genes and the environment interact to influence health and disease. Around 1000 people visited the stall over 5 days at Green Man 2014 and around 600 people visited the stall over 2 days at the BiB cohort festival 2014. Visitors at Green Man were festival-goers (general public. Visitors at BiB were mainly cohort participants (children aged ~5-7) and their families, although the event was held at Bradford's Media Museum, which is open to the general public.
Year(s) Of Engagement Activity 2014
URL https://twitter.com/genegenies
 
Description Genomics, Epigenomics and Causal Inference in Population Health, Federal University of Pelotas, Brazil 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Approximately 30 participants attended a short course introducing the concepts of epigenetics and epigenetic analysis. Attendees were post-doctoral research students, academic staff and NHS workers.
Year(s) Of Engagement Activity 2015
 
Description Harvard School of Public Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited Speaker: Seminar: Harvard School of Public Health, Boston, USA, January 2014

Informed debate and discussion
Year(s) Of Engagement Activity 2014
 
Description Hidden Influences on Health Across the Life Course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Health professionals
Results and Impact Seminar at University of Durham June 2013 - Hidden Influences on Health Across the LIfe Course

Informed discussion
Year(s) Of Engagement Activity 2013
 
Description Integrative Cancer Epidemiology Programme Launch Event at MShed 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This event was to Launch the Integrative Cancer Epidemiology Programme. The day consisted of scientific presentations from various academics, both involved in the project and specialists in the cancer field. There were about 80 attendees, some travelling from Europe, all had registered to attend. The majority of the audience were from a scientific background, with some A level students also attending. The event allowed people to hear about work which would be undertaken during ICEP and facilitated networking and discussions about the programme and future work. The event had media interest and appeared on the BBC Points West News.
Year(s) Of Engagement Activity 2015
URL http://www.bristol.ac.uk/social-community-medicine/projects/icep/launchevent/
 
Description Interactive art installation - Einstein's Garden, Green Man festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact DATA MINE was an interactive art installation in Einstein's Garden in 2016. This piece was developed by MRC IEU researchers and designer Philippa Thomas aimed to engage visitors to the Green Man festival about the human genome and how we can use it in epigenetics and genetics research. The installation was filled with coloured ribbons to attracted visitors in, each ribbon acting as a genetic trait.
Year(s) Of Engagement Activity 2016
URL http://www.bristol.ac.uk/integrative-epidemiology/news/2016/data-mine.html
 
Description Invited Presentation: Lecture: Genomics Symposium, Biogen Idec, Boston 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This symposium was organised by Biogen Idec and was largely to inform their workforce about recent developments in genomic sciences. The workshop involved presentations, debate and one-to-one discussions on topical issues and research priorities in the pharmaceutical industry.
Year(s) Of Engagement Activity 2015
 
Description Invited Presentation: Plenary: Neonatal Update; The Science of Newborn Care. London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This invited lecture (and linked review paper) provided an overview of causal analysis methods in birth cohorts. The lecture was recorded and was made available on the meeting website.The review paper has 15 cites to date. Several requests for advice and/or collaboration ensued.
Year(s) Of Engagement Activity 2014
 
Description Invited Presentation: Workshop Saguenay Collaborative Workshop, Chicoutimi, Quebec 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This invited workshop involved reviewing the Saguenay Youth Study scientific priorities, providing a series of lectures on our recent research.Meetings with other groups were undertaken.
Year(s) Of Engagement Activity 2015
 
Description Invited speaker at IGMM (Edinburgh) - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI for ICEP) was invited to give a presentation at the Institute of Genomic and Molecular Medicine at the University of Edinburgh. Professor Relton's talk was entitled Using genotype as a causal anchor in epigenetic studies. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Invited speaker at Rank Prize Funds Symposium - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI of ICEP) was an invited speaker at the Rank Prize Funds Symposium on Maternal and Paternal Intergenerational Programming Effects in Cumbria. Professor Relton gave a talk entitled Parental influences on the epigenome: Evidence from human cohort studies. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Keystone Symposium Boston USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited Speaker: Keystone Symposium: Epigenetic Programme and Inheritance, Boston, USA April 2014

Dissemination of information and discussion
Year(s) Of Engagement Activity 2014
 
Description MRC IEU Open Day (Gemma Sharp) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact I helped run the MRC Open Day, which was attended by several classes from a local school. We carried out activities related to our research and talked to them about our careers and specific research areas.
Year(s) Of Engagement Activity 2016
 
Description NIHR-BRC Geneomics Workshop, Newcastle University 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Health professionals
Results and Impact NIHR-BRC Genomics Workshop, Newcastle University, 18th July 2013

Informed debate and discussion.
Year(s) Of Engagement Activity 2013
 
Description Population Health: Past, Present and Future 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information and discussioin

Invited Speaker: Population Health: Past, Present and Future. University of Michigan, Ann Arbor, USA, April 2014
Year(s) Of Engagement Activity 2014
 
Description Poster presentation Epigenomics of Common Diseases Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Matthew Suderman from the E4 project team presented a poster entitled 'DNA methylation proxy for exposure and outcome prediction' at the Epigenomics of Common Diseases conference in Cambridge to an audience of academics and post doctoral researchers. In relation to the poster presentation, there was discussion about how to solve some of the challenges related to prediction.

Authors:
Matthew Suderman, Gemma Sharp, Leanne Küpers, Fahimeh Falahi, Janine Felix, Harold Snieder, Ellen A. Nohr, Thorkild I. A. Sørensen, Caroline Relton, George Davey Smith.

Abstract:
Many environmental exposures particularly in early development are known to influence later health outcomes. Unfortunately records of exposure tend to be based on self-report long after the exposure has occurred and therefore lack precision and objectivity. A possible solution is to infer exposure from stable, accessible biomarkers. DNA methylation measured in peripheral tissues is a promising candidate because it is commonly measured in many human cohort studies and is known to retain associations with certain exposures for many years. As a proof of principle, we created proxies for prenatal tobacco exposure (PTE) using cord blood DNA methylation levels. We then asked how well the proxies correlate with PTE and well-known outcomes of PTE. We were indeed able to derive accurate DNA methylation proxies for PTE and showed that accuracy could be improved by including certain data preprocessing steps as well as including association effect information from large meta-analyses of PTE in DNA methylation. Our proxies also related to known PTE outcomes similarly to PTE but did identify cases of collider bias introduced by certain data preprocessing steps. In future we will further investigate approaches for improving proxy accuracy and preventing collider bias.
Year(s) Of Engagement Activity 2016
URL http://bristol.ac.uk/integrative-epidemiology/epigenetics-social-science-network/news/2016/-dna-meth...
 
Description Presentation at Big Data conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI of ICEP) was an invited speaker at the Big Data in Biology and Health Conference in Cambridge. Professor Relton gave a talk entitled (Epi)genetic epidemiology in the era of big data. Professor Relton is also on the scientific programme committee for this event and was chair for the Analytics Session. This raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Presentation at Kings College London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI of ICEP) was an invited speaker at the Epigenetics & Social Science Network Meeting at Kings College London. Professor Relton gave a talk entitled E4: Epigenetics, Environment, Embodiment, Equality. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Presentation at NTNU (Trondheim) - C Relton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Caroline Relton (PI of ICEP) was an invited speaker at the Studying Genomic Variation in Populations conference at the KG Jebsen Center for Genetic Epidemiology, NTNU in Trondheim. Professor Relton gave a talk entitled Epigenetics and non-communicable diseases. The presentation raised the profile of Professor Relton and her research.
Year(s) Of Engagement Activity 2017
 
Description Presentations at MR Conference (Bristol) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The 3rd International Mendelian Randomization Conference in Bristol was organised by Professor George Davey Smith and he gave a talk entitled: Does MR have any place in the Social Sciences. Caroline Relton (PI of ICEP) was an invited speaker and gave a talk entitled: Mendelian randomisation for molecular mediation. Paul Brennan (Co-I of ICEP) was an invited speaker and gave a talk entitled: Elucidating the role of BMI and diabetes in cancer using an MR approach. Robert Carreras-Torres (ICEP Researcher) was an invited speaker and gave a talk entitled: Solving complex relationships between metabolic parameters and cancer risk: from Mendelian randomization to matrix analysis. Various other ICEP members attended the event and were involved by chairing sessions and presenting posters. This raised the profile of ICEP related research.
Year(s) Of Engagement Activity 2017
URL https://www.mendelianrandomization.org.uk/programme/
 
Description Public Engagement stall at Einstein's Garden, Green Man Festival, Wales 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This public engagement activity provided and introduction to genetic variation to the general public at a large music/science festival. A wide age range was reached.
Year(s) Of Engagement Activity 2015
 
Description Public Lecture; How life gets under the skin; Mshed 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact How does our environment shape who we are? Old notions of nature and nurture are today being overturned by the emerging science of epigenetics, the study of how our genes can be switched on or off by environmental factors such as nutrients, toxins and hormones. In recent years epigenetic mechanisms have been used to explain observations such as the differences between identical twins and the effect of early trauma on health in later life. Now the social and life sciences are finding common ground through epigenetics, as a way of explaining how life experiences and lifestyle choices shape the human organism. This event brings together thinkers from the biological and social sciences to explore what epigenetics can tell us about how life 'gets under the skin', leaving a trace on our genome and influencing our future health. If the social environment really does alter the way our genes are expressed, what can we do about it? Join our panel for a lively discussion on how epigenetics is extending the debate on the significance that environment and lived experience plays in making us who we are.
Speakers:
•Nessa Carey, author of 'The Epigenetics Revolution'
•George Davey Smith, Professor of Clinical Epidemiology and Director of the MRC IEU, University of Bristol
•Nikolas Rose, Professor of Sociology and Head of the Department of Social Science, Health and Medicine, King's College London
Chair:
•Caroline Relton, Professor of Epigenetic Epidemiology at the MRC IEU, University of Bristol
This event is programmed by the MRC Integrative Epidemiology Unit (IEU), a research unit at the University of Bristol that uses genetics, population data and experimental interventions to look for the underlying causes of chronic disease. This event is funded through a 'Transforming Social Science' award from the Economic and Social Research Council (ESRC).
Year(s) Of Engagement Activity 2015
URL https://www.eventbrite.com/e/how-life-gets-under-the-skin-tickets-16577496739
 
Description Public debate: "Electronic cigarettes: the key to reducing smoking?" at the M Shed 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Following the ICEP launch event at the M Shed in Bristol, there was an evening public lecture linked to both the CRUK Integrative Cancer Epidemiology Programme and MRC Integrative Epidemiology Unit. This event was widely advertised and open to the public. There was a structured debate between two specialists in the smoking field, with questions and comments from the audience. The debate sparked discussions and interest. An article was published in the Guardian reporting on the event.
Year(s) Of Engagement Activity 2015
 
Description Public engagement talk for CRUK fundraisers entitled "Integrative cancer research for cancer prevention", Devizes, Wiltshire (Srikant Ambatipudi) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact The talk was attended by 30-35 supporters of the Cancer Research UK (CRUK). CRUK supporters were happy to learn how the money raised by them is contributing towards cancer prevention.
Year(s) Of Engagement Activity 2016
 
Description Three minute video production for YouTube - Epigenetics 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Production on a three minute primer video where Caroline Relton gives a brief overview of Epigenetics, placed on YouTube.
Year(s) Of Engagement Activity 2017
URL https://www.youtube.com/watch?time_continue=1&v=6CaQlUpvy5U
 
Description UK Environmental Mutagens Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Lecture: UK Environmental Mutagens Society, Newcastle University, December 2013

Informed discussion and debate
Year(s) Of Engagement Activity 2008,2013
 
Description Visit from collaborators at Sanofi to our department in Bristol, UK. and a return visit in Framingham, USA. (Tom Richardson) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact We had two exchanges with collaborators from Sanofi this year, the first took place in Bristol, UK in July and the other in Framingham, USA in October. During these exchanges we discussed for a day of presentations and discussion. This helped us to develop our working relationship, as well as discuss progress on current research and future projects.
Year(s) Of Engagement Activity 2016
 
Description World Congress in Epidemiology, Anchorage, Alaska 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information and discussion

Invited Speaker: World Congress of Epidemiology, Anchorage, Alaska, USA, August 2014
Year(s) Of Engagement Activity 2014