Integrative epidemiology for exploring how women’s reproductive health influences cardiometabolic health.

Lead Research Organisation: University of Bristol

Abstract

(around 200 words – max. 1,500 characters including spaces) We are trying to find out how to improve the success of in-vitro fertilisation (IVF) and make sure that women who have conceived by IVF or ‘naturally’ have a healthy pregnancy and birth.
IVF is common. In an average school class of 30 children 1 will have been born by IVF. New ways of using IVF might improve success rates but they need to be carefully evaluated.
Whether women conceive by IVF or naturally up to 40% will have one or more of pregnancy loss, high blood pressure or high blood sugar in pregnancy, a premature birth or an infant who is born unhealthily small or large. We do not know how to prevent these problems or predict which women will experience them.
We will use data from very large studies and new methods that help us to determine causes from ‘confounders’ (factors that fool us into thinking that something is a cause when it is not). This will allow us to work out how to improve IVF and prevent pregnancy problems. It will also improve our understanding of what risk factors in pregnancy affect children’s risk of being obese or having diabetes or heart problems later in their lives.

Technical Summary

Our aim is to provide the evidence base that will improve treatment success with IVF and enable stratified and effective antenatal care in IVF and spontaneous conceptions (SC).
This is important because up to 40% or pregnancies are affected by one or more of miscarriage, stillbirth, hypertensive disorders of pregnancy, gestational diabetes, preterm birth or delivery or a small or large for gestational aged infant, but we do not know the best way of preventing these. IVF is now the commonest treatment for infertility with >250K IVF cycles completed per year in the UK and on average 1 in 30 primary school children were born as a result of in vitro fertilisation (IVF). Success rates vary by couple and treatment characteristics but are between 20-30%. There are suggestions that IVF per se, and pregnancy complications in IVF and SC have important adverse effects on future offspring cardio-metabolic health, but whether these associations are causal and if so their magnitude is unclear.
Our objectives are to accurately predict and identify causal paths for: (i) response to IVF; (ii) healthy pregnancy and perinatal outcomes in IVF and SC; and (iii) offspring cardio-metabolic health.
Methods
Our focus will primarily be on maternal smoking, physical activity, sleep patterns, adiposity, pregnancy metabolic profiles and fetal (cord-blood) DNA methylation as potential predictors or risk factors.
We will use data from detailed clinical and general pregnancy/birth cohorts. We will work with relevant consortia, including the EuroCHILD pan-European birth cohort that we are involved in establishing from 26 existing cohorts, early growth genetics (EGG) consortia, in which we co-lead maternal-offspring genetic analyses, the Genetics of Diabetes In Pregnancy (GENdip) consortia that we have recently developed, and the pregnancy/birth cohorts working group aligned to the Consortia Of METabolomics Studies (COMETS), which we lead, as well as the Pregnancy And Child Epigenetics (PACE) consortia, which we work closely with alongside Relton’s MRC Integrative Epidemiology Unit programme. We will triangulate results across the following analytical methods applied to these data sources: multivariable regression (MV), Mendelian randomization (MR), non-genetic instrumental variable (IV) analyses, within sibship and negative control studies.
Translation
Building on our successful impact on clinical guidelines in the first five-years of this programme, we will continue to work with relevant clinicians, patient groups and NICE guideline developers. For new methodological developments we will provide and share datasets and code and widely disseminate these.

Publications

10 25 50

publication icon
Anderson EL (2016) Physical Activity Is Prospectively Associated With Adolescent Nonalcoholic Fatty Liver Disease. in Journal of pediatric gastroenterology and nutrition

 
Description HFEA guidelines
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact This led to a change in the number of embryos that could be transferred at any one time
 
Description Advanced Grant
Amount € 1,800,000 (EUR)
Funding ID 669545 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 11/2015 
End 10/2020
 
Description Association of birthweight with perinatal, infant and maternal outcomes: A population linkage study
Amount £129,549 (GBP)
Funding ID RG2028 
Organisation Wellbeing of Women 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 02/2020
 
Description Australian NHMRC (LIMIT)
Amount $674,010 (AUD)
Funding ID APP1043178 
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2013 
End 12/2015
 
Description BHF 4-year doctoral training programme: Integrative cardiovascular science
Amount £2,500,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2021
 
Description Biomedical Research Centres
Amount £21,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Bristol NIHR Biomedical Research Centre
Amount £20,858,545 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Causal pathways from maternal obesity to pregnancy, perinatal & childhood health outcomes
Amount $755,934 (AUD)
Funding ID APP1068320 
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2014 
End 12/2016
 
Description Clinical Study
Amount £1,016,398 (GBP)
Funding ID CS/16/4/32482 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Cohort Funding
Amount £2,700,000 (GBP)
Funding ID MR/N024397/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Developmental overnutrition, DNA methylation and offspring cardiovascular health MRC
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Early life adversity and trajectories of cardiometabolic health, cognitive function and physical function: improving understanding of the mechanisms and potential reversibility - Joint funding ESRC and US National Institute on Ageing
Amount £234,480 (GBP)
Funding ID ES/M010317/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2014 
End 05/2016
 
Description Early life determinants of pre-adolescent differences in cardiometabolic health between South Asian and White British children: The born in Bradford (BiB) cohort.
Amount £1,016,398 (GBP)
Funding ID CS/16/4/32482 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 02/2022
 
Description Early-life stressors and LifeCycle health.
Amount € 764,022 (EUR)
Organisation European Union 
Sector Public
Country European Union (EU)
Start 01/2017 
End 12/2021
 
Description Establishing a national, population based cohort of children born after assisted conception in the UK - MRC
Amount £270,000 (GBP)
Funding ID MR/L020335/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Excessive drinking and alcohol related harms in Adulthood - MRC
Amount £1,736,826 (GBP)
Funding ID MR/L022206/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Genetic, behavioural and cognitive mechanisms underpinning the association between mother and offspring mental health problems: mental (M) health (H) intergenerational transmission (MHINT).
Amount € 1,499,611 (EUR)
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 10/2017 
End 09/2022
 
Description HIgh resolution analysis of biological and environmental determinants of cardiovascular risk factors and cardiovascular events in older woment - BHF
Amount £296,808 (GBP)
Funding ID PG/13/66/30442 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Horizon 2020
Amount € 9,957,602 (EUR)
Funding ID 733206 
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 01/2017 
End 12/2021
 
Description Improved methodology for estimating the effects of school-based intervention on physical activity in children
Amount £30,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2015
 
Description Lifelong Health and Wellbeing (joint UKRCs)
Amount £1,502,949 (GBP)
Funding ID G1001357 
Organisation Medical Research Council (MRC) 
Department MRC Regional Centre London
Sector Public
Country United Kingdom
Start 09/2011 
End 08/2016
 
Description MRC Career Development award- Abi Fraser
Amount £843,203 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2014 
End 11/2019
 
Description MRC Career Development award- Laura Howe
Amount £783,730 (GBP)
Funding ID MR/M020894/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 08/2020
 
Description MRC Integrative Epidemoilogy Unit.
Amount £12,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 03/2023
 
Description MRC Population Health Scientist- Linda O'Keefe
Amount £347,246 (GBP)
Funding ID MR/M014509/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 08/2015 
End 07/2019
 
Description MRC Research grant (UPBEAT)
Amount £825,398 (GBP)
Funding ID MR/L002477/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2014 
End 01/2018
 
Description Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition - NIH
Amount $2,330,865 (USD)
Funding ID R01DK10324 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2014 
End 07/2019
 
Description NIHR HTA call
Amount £271,625 (GBP)
Funding ID 11/99/02 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 03/2013 
End 02/2016
 
Description Prediction and prevention of adverse outcomes in pregnancies complicated by placental dysfunction
Amount £24,490 (GBP)
Organisation David Telling Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 02/2019
 
Description Provision of high-resolution proteomics to enchange forward and back translational research - Wellcome Trust
Amount £399,998 (GBP)
Funding ID 10491/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Sleep disturbance: new insights into the clinical impact in diabetes
Amount £257,928 (GBP)
Funding ID 17/0005700 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2021
 
Description The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways
Amount £250,000 (GBP)
Funding ID MR/R004803/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 09/2019
 
Description The relationship of the menopausal transition to healthy ageing and chronic disease risk.
Amount £1,226,786 (GBP)
Funding ID WT092830M 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2011 
End 06/2016
 
Description Understanding the role of fatty acids in the aetiology of cardiovascular disease using novel causal inference method
Amount £280,000 (GBP)
Funding ID MR/P014054/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2017 
End 06/2020
 
Title Development of Triangulation method for causal inference 
Description Study design and analytical method for improving causal inference Paper published in IJE and work presented at (a) Causal inference workshop in Harvard Boston USA November 2016 and (b) at the London School of Hygiene & Tropical Medicine to MSc, PhD students and staff March 2017 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2016 
Provided To Others? Yes  
Impact To date too early to tell 
 
Description 25(OH)D GWAS in children 
Organisation University of Queensland
Department Genetic Epidemiology Laboratory
Country Australia 
Sector Public 
PI Contribution We are leading this collaboration which includes teams from Australia (QIMR and Perth) and the US (NHANES) who are working with us to identify genetic variants associated with 25(OH)D, calcuim, phosphate and PTH in children.
Collaborator Contribution Replication sample for our GWAS, which will be published Replication of our GWAS analysis, which will be published
Impact Draft first publication currently being circulated amongst co-authors. The collaboration is multidisciplinary including epidemiologists, statisticians, geneticists and bioinformaticians.
Start Year 2010
 
Description 25(OH)D GWAS in children 
Organisation University of Western Australia
Department School of Population Health
Country Australia 
Sector Academic/University 
PI Contribution We are leading this collaboration which includes teams from Australia (QIMR and Perth) and the US (NHANES) who are working with us to identify genetic variants associated with 25(OH)D, calcuim, phosphate and PTH in children.
Collaborator Contribution Replication sample for our GWAS, which will be published Replication of our GWAS analysis, which will be published
Impact Draft first publication currently being circulated amongst co-authors. The collaboration is multidisciplinary including epidemiologists, statisticians, geneticists and bioinformaticians.
Start Year 2010
 
Description Birth cohorts metabolomics partnership 
Organisation Bradford Institute for Health Research (BIHR)
Country United Kingdom 
Sector Academic/University 
PI Contribution A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites.
Collaborator Contribution Established the cohort Applying for funds to extend it
Impact None to date
Start Year 2014
 
Description Birth cohorts metabolomics partnership 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites.
Collaborator Contribution Established the cohort Applying for funds to extend it
Impact None to date
Start Year 2014
 
Description Birth cohorts metabolomics partnership 
Organisation Federal University of Pelotas (UFPel)
Country Brazil 
Sector Academic/University 
PI Contribution A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites.
Collaborator Contribution Established the cohort Applying for funds to extend it
Impact None to date
Start Year 2014
 
Description Birth cohorts metabolomics partnership 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites.
Collaborator Contribution Established the cohort Applying for funds to extend it
Impact None to date
Start Year 2014
 
Description Birth cohorts metabolomics partnership 
Organisation University of Adelaide
Country Australia 
Sector Academic/University 
PI Contribution A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites.
Collaborator Contribution Established the cohort Applying for funds to extend it
Impact None to date
Start Year 2014
 
Description Birth cohorts metabolomics partnership 
Organisation University of the Witwatersrand
Country South Africa 
Sector Academic/University 
PI Contribution A collaboration of birth cohorts with maternal serum samples suitable for metabolomics analyses or with measured metabolites.
Collaborator Contribution Established the cohort Applying for funds to extend it
Impact None to date
Start Year 2014
 
Description Born in Bradford 
Organisation Bradford Institute for Health Research (BIHR)
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating with the Born in Bradford cohort to examine the association of maternal 25(OH)D in pregnancy with pregnancy complications.
Collaborator Contribution Advances understanding of the relationship of 25(OH)D to pregnancy complications. Output includes research journal publications.
Impact Two papers are currently at advanced darft status. One examines associations with results from oral glucose tolerance tests in pregnancy and the second with hypertensive disorders of pregnancy.
Start Year 2010
 
Description CHICOS 
Organisation CHICOS: Developing a Child Cohort Research Strategy for Europe
Country European Union (EU) 
Sector Academic/University 
PI Contribution Overall aim is to improve child health across Europe by developing an integrated strategy for mother-child cohort research in Europe. Methodologically we are working on ways of harmonising data and comparing results between and, where appropriate, pooling data from all European mother-child cohorts. I lead the work on child obesity and cardiometabolic health. I contribute data and/or analyses results for reserach that other partners lead in other research areas.
Collaborator Contribution Partners contribute data or results from analyses for research that I lead on child obesity and cariometabolic health.
Impact Publications currently being drafted
Start Year 2010
 
Description LIMIT RCT group 
Organisation University of Adelaide
Department Discipline of Obstetrics and Gynaecology
Country Australia 
Sector Academic/University 
PI Contribution I am a co-applicant on the follow-up grant for this RCT in overweight and pregnant women that is based in Adelaide. I am also a co-applicant on a small pilot grant that funds obtaining DNA methylation data on a subgroup of participants in the RCT. This trial and a similar (UPBEAT) UK trial are central to my MRC IEU programme and I lead analyses on pooling data related to long-term follow-up in both trials.
Collaborator Contribution The teams at the University of Adelaide and Kings College London (where UPBEAT is based), together with collaborators at the University of Glasgow, work with me and my team to explore the effects of lifestyle interventions in women who start their pregnancies overweight/obese on long term outcomes in mother and offspring - including adiposity and metabolomics outcomes - and the extent to which these are mediated by epigenetic modificaiton.
Impact Successful grant: Dodd J (PI), Lawlor DA, McPhee A, Moran L, Yelland L, Gillman M, Robinson J. The contribution of maternal obesity and gestational weight gain to preschool child obesity (long-term follow-up of the LIMIT RCT). NHMRC (Australia) (APP1043178). AU$674,010 (equivalent to ~ £435,613): January 2013-December 2015
Start Year 2012
 
Description UCLEB 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution One of the key partners Collaboration is concerned with the use of genetics in risk prediction and aetiology (Mendelian randomization) of cardiometabolic disease. Includes the use of metabolomics
Collaborator Contribution As above
Impact Large number of publications - See CV
Start Year 2007
 
Description UCLEB 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution One of the key partners Collaboration is concerned with the use of genetics in risk prediction and aetiology (Mendelian randomization) of cardiometabolic disease. Includes the use of metabolomics
Collaborator Contribution As above
Impact Large number of publications - See CV
Start Year 2007
 
Description UPBEAT RCT 
Organisation King's College London
Department Women's Health Academic Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution I am a co-applicant on a recently obtained MRC grant related to adding metabolomics data to this RCT I will lead analyses of this RCT and the LIMIT RCT (see other entry) in relation to long term mother and offspring outcomes in particular adiposity and metabolomics outcomes.
Collaborator Contribution See entry for LIMIT RCT collaboration
Impact Successful grant Poston L, Lawlor DA, Nelson SM, Sattar N. The UPBEAT RCT mother-child study. Stratifying and treating obese pregnant women to prevent adverse pregnancy, perinatal and longer term outcomes. MRC £825, 398: February 2014 for 48 months Published book chapter: Fraser A, Lawlor DA. Long-term consequences of maternal obesity and gestational weight gain for offspring obesity and cardiovascular risk - intrauterine or shared familial mechanisms? In: Poston L, Gillman M (eds). Obesity and Pregnancy. Cambridge Press. 2012
Start Year 2012
 
Description Vitamin D and pregnancy outcomes 
Organisation University of Bradford
Department Bradford Research Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution I am a co-applicant on a successful grant (Diabetes UK) which funds completion of vitamin D assays with pregnancy glucose tolerance test outcomes (fasting and postload glucose, fasting insulin and gestational diabetes) in the Born in Bradford cohort. The focus of that grant was on gestational diabetes, which is poorly measured in ALSPAC, but nonetheless we will use the assays completed on stored samples in the ALSPAC mothers (funded by this MRC grant) to further explore this question using glycosuria and a medical record review diagnosis of gestational diabetes. We have excellent repeat measurements of blood pressure and proteinuria during pregnancy and hence hypertensive disorders of pregnancy in ALSPAC mothers and reasonable measurements in the Born in Bradford study and so both studies will be used to explore the relationship of vitamin D to these outcomes.
Collaborator Contribution We will share, and where appropriate pool, results from the ALSPAC cohort (funded by this MRC grant) and the Born in Bradford cohort (funded by the Diabetes UK grant)
Impact Grant from Diabetes UK to examine the relationship of Vitamin D with gestational diabetes and fasting and postload glucose in the Born in Bradford Cohort. The collaboration is multidisciplinary, bringing together expertise in epidemiology (DA Lawlor, University of Bristol), clinical endocrinology (D Whitelaw, University of Bradford), obstetrics (S Nelson, University of Glasgow), clinical biochemistry (N Sattar, University of Glasgow), vitamin D/bone health expertise (W Fraser, University of Liverpool) and health services research (J Wright, University of Bradford).
Start Year 2009
 
Description Bristol City Council Women's Health Public Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Bristol City Council are interested in tacking some of the issues raised in the 2015 Chief Medical Officer's annual report related to menopause and the work place. We were invited to present at this inaugural public event. Isabel de Salis (SRF Medical Anthropologist, funded by this grant) presented our work on 'Time of Our Lives' covering women's views and attitudes. It was very well received.
Year(s) Of Engagement Activity 2017
 
Description Childhood obesity and the first nine months of life. Keynote lecture - Turin 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2014
 
Description Confounder control in reproductive epidemiology. Keynote Leture. European Congress of Epidemiology, Aarhus Denmark 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impacts
Year(s) Of Engagement Activity 2013
 
Description Contribution to Radio 4 'Inside Science' 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I was interviewed for 20 minutes by Adam Rutherford for the radio 4 programme 'Inside Science' programme. The content was reduced to ~ 10 minutes of the 30 minute programme aired on March 3rd 2016. The interview was concerned with birth cohorts and their scientific impact. It was done jointly with Prof Diana Kuh in the week of the 70th anniversary of the longest running Birth cohort which Diana directs - the 1946 birth cohort.
The programme is available currently at
http://www.bbc.co.uk/programmes/b071ld09
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b071ld09
 
Description Developmental origins of greater fatness in South Asians. Guest Lecture - International Epidemiology Association, Vilnious, Lithuania 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2014
 
Description Developmental origins of the 'thin-fat' phenotype in South Asian people. Guest Lecture - Uni of Queenland School of Population Health, Brisbane Australia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description Does the South Asian 'thin-fat' phenotype develop in utero? Guest Lecture - Massey University Public Health Centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description Extensive coverage of our paper showing live birth rates with repeat IVF treatment 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Widespread coverage in national and international media, for example:

Couples using IVF should anticipate needing at least six cycles, scientists say (Web)
Telegraph - 22/12/2015

Couples should get 'multiple IVF treatment cycles' (Web)
The Irish News - 23/12/2015

Couples should be given 'multiple IVF treatment cycles', study claims (Web)
Yahoo! UK and Ireland - 23/12/2015

BBC Radio Scotland - 22 December 2015 - 17:42:00
BBC Radio Scotland - 22/12/2015 17:42:00
Couples seeking fertility treatment should view IVF as a multiple-cycle process instead of a single shot at having a family, according to Bristol and Glasgow universities. Includes interview with Professor Scott Nelson of Glasgow University.

BBC Radio Scotland - 22 December 2015 - 15:36:27
BBC Radio Scotland - 22/12/2015 15:36:27
A study at the University of Glasgow suggests we need to rethink how many IVF treatments are needed to produce a live birth.



http://www.nytimes.com/2015/12/23/health/with-in-vitro-fertilization-persistence-pays-off-study-suggests.html


Couples should be given 'multiple IVF treatment cycles', study claims
Yahoo! UK and Ireland - 23 Dec 2015 01:18
Couples seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to research. The study found 65.3% of patients - about two...

Couples should get 'multiple IVF treatment cycles'
The Irish News - 23 Dec 2015 01:14
COUPLES seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to research. The study found 65.3 per cent of patients -...

Two thirds of IVF couples will have a baby after six attempts
Bloomberg - 22 Dec 2015 17:09
Couples seeking fertility treatment should view IVF as a multiple cycle process rather than a "single shot", according to new research. The study, which is published today in The Journal of The...
Couples should be given 'multiple IVF treatment cycles', study claims
Guernsey Press - 22 Dec 2015 17:00
Couples seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to research. The study found 65.3% of patients - about two...

Couples should be given 'multiple IVF treatment cycles', study claims
Falkirk Herald - 22 Dec 2015 16:40
Couples seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to research. The study found 65.3% of patients - about two thirds - will be successful following six or more cycles...

Couples should be given 'multiple IVF treatment cycles', study claims
Ellon Times - 22 Dec 2015 16:31
Couples seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to research. The study found 65.3% of patients - about two...

Couples should be given 'multiple IVF treatment cycles', study claims
BT.com - 22 Dec 2015 16:30
Couples seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to research. Couples seeking fertility treatment should...

Couples should be given 'multiple IVF treatment cycles', study claims
Press and Journal - December 2015by Press Association - 22 Dec 2015 16:24
Couples seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to research. The study found 65.3% of patients - about two thirds - will be successful following six or more...

Couples should be given 'multiple IVF treatment cycles', study claims
MyInforms - 22 Dec 2015 16:24
Couples seeking fertility treatment should view IVF as a multiple cycle process instead of a "single shot" at having a family, according to Couples seeking fertility treatment should view IVF as...
Year(s) Of Engagement Activity 2015,2016
 
Description Incorporating epigenetics into an epidemiological framework. Pre-conference workshop - 8th World Congress on the Developmental Origins of Health and Disease, Singapore 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description Innovative approaches to causal inferences in observational epidemiology. Guest Lecture fPelotas, Brazil 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impacts
Year(s) Of Engagement Activity 2013
 
Description MRC Parliamentary show case 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact A group of MRC scientists had stalls at parliament for parliamentarians to discuss our research with us. Together with Max Palmer and Kate Hunt, I presented up dates in population health, including discussions of causal analyses, adaptive RCTs, data-sharing and record linkage
Year(s) Of Engagement Activity 2017
 
Description Maternal pregnancy adiposity and glucose intolerance and offspring later adipostiy - evidence for causal effects in humans. Keynote address, Australian and New Zealand Annual Scientific Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description Maternal pregnancy obesity - moving into intervention studies. Pre-conference workshop. 8th World Congress on the Developmental Origins of Health and Disease, Singapore 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description Mayor of Bristol Young Peoples work & mentoring 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This is a scheme that provides support and mentorship to 16-18 year olds from deprived backgrounds
Year(s) Of Engagement Activity 2017
 
Description Our Menopauses: an event for sharing experiences and information about menopause in Bristol 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact An interactive workshop for women to share their experience of the menopausal transition and discuss what is know about its health, societal and occupational impact
Year(s) Of Engagement Activity 2017
 
Description Production of policy engagement document for alcohol consumption in pregnancy 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Loubaba Mamlyk along with others from the MRC IEU ran a systematic review of all studies that supported the review of government guidelines on alcohol consumption during pregnancy. They produced a fact sheet to be able to hand out at public events and clinics to provide pregnant women with the information they need.
Year(s) Of Engagement Activity 2016
 
Description Prospective cohort versus cross-sectional studies; is the extra time and expense worth the effort. Plenary Session - Australasian Epidemiology Association Annual Scientific Meeting, Brisbane Australia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description Radio 4 Inside Science 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Participated in Inside Science radio 4 programme - discussing the value of population cohort studies for understanding causes of disease and how to prevent these
Year(s) Of Engagement Activity 2016
 
Description The effect of developmental overnutrition on overweight and obesity. Guest Lecture - International Epidemiology Association, Hangzhou, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description The intergenerational transmissing of adipostiy and glucose intolerance. Guest Lecture Pelotas, Brazil 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2013
 
Description You CAN't do that! Myths about career progression in academic medicine. Keynote Lecture - Academy of Medical Sciences Developing a Career in Medicine Annual Meeting - Leeds 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of information

No known notable impact
Year(s) Of Engagement Activity 2014