Functional trajectories and cardiovascular ageing

Lead Research Organisation: University College London

Abstract

We aim to identify risk factors from all stages of life which are associated with the development of cardiovascular disease (CVD). Around one in two men and one in three women suffer a cardiovascular event sometime during life, making CVD a major cause of ill health and death. Although clinical disease only becomes evident at older ages, plaque in the arteries is present by young adulthood. This suggests that exposures and lifestyle from childhood, adolescence and early adulthood have an impact on the development of CVD.

We have collected a comprehensive set of measures of cardiac and vascular structure and function in the MRC National Survey of Health and Development (NSHD), a cohort study of men and women followed since their birth in March 1946. A major focus of our research is on overweight and high blood pressure, as these are two of the main modifiable causes of CVD. The NSHD already has measures of body size and blood pressure across different stages of life. We investigate the impact of earlier life overweight and blood pressure and their patterns of change on cardiovascular ageing. We also investigate the life time predictors of change in body size and blood pressure.

This work will be important in understanding whether treatment and intervention from a much earlier age than is routine in current clinical practice could yield benefits for CVD prevention.

Technical Summary

Understanding pathways to cardiovascular (CV) ageing are important because, although deaths from heart and circulatory disease are falling, they remain the main cause of premature mortality in the UK. The overall aim of this programme is to identify possible novel intervention strategies and screening opportunities at all stages of the life course which would promote good CV function for as long as possible, and thus prevent or delay the onset of disease, extend the healthy lifespan and improve wellbeing and quality of life. In order to do this we have collected a comprehensive set of measures of cardiac and vascular structure and function as well as repeat measures of CV risk factors in the MRC National Survey of Health and Development, a cohort study of men and women followed since their birth in March 1946. We have previously shown how factors acting during gestation, childhood, adolescence and adult life affect body mass index (BMI) and blood pressure (BP) trajectories and other CV risk factors in the NSHD and across cohorts. With the new NSHD data, our objectives are: to identify life course predictors of BMI, BP and resting heart rate (RHR) lifetime trajectories; to identify the life course risk and protective factors associated with the vascular and cardiac phenotypes at 60-64 years and to understand their cumulative and interactive effects; and to investigate the biological pathways and mechanisms underlying CV ageing and its relationship with ageing of other body systems. In the longer term, the objectives are to assess the predictive power of the cardiac and vascular phenotypes on CV function decline and progression to disease, and the impact of CV ageing on quality of life and wellbeing. This programme will provide key evidence to inform clinical guidelines for the prevention of CVD for the early identification and more targeted management of individuals at risk, and aims to improve CVD risk prediction by incorporating longitudinal trajectories of risk factors and novel biomarkers. This programme addresses the MRC strategic research priority for 2009-14 to improve the chances of living a long and healthy life by taking a life course approach to the investigation of CV ageing.

Publications

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Allinson JP (2018) Childhood Exposures, Asthma, Smoking, Interactions, and the Catch-Up Hypothesis. in Annals of the American Thoracic Society

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Allinson JP (2017) Combined Impact of Smoking and Early-Life Exposures on Adult Lung Function Trajectories. in American journal of respiratory and critical care medicine

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Allinson JP (2018) Childhood Exposures, Asthma, Smoking, Interactions, and the Catch-Up Hypothesis. in Annals of the American Thoracic Society

 
Description CLOSER Workshop - Cross-cohort research: Opportunities, challenges and examples
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased researcher awareness and understanding of the challenges and opportunities related to cross cohort research
 
Description CLOSER Workshop - Cross-cohort research: Opportunities, challenges and examples
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased knowledge and awareness of Cross-cohort research: Opportunities, challenges and examples
 
Description CLOSER Workshops
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased awareness and understanding of researchers in the following areas Functioning well in later life: What is the evidence from longitudinal studies?* ** Symposium January 15th 2013 Knowledge Exchange Workshop: Challenges for Data Harmony* ** KEW January 16th 2013 Knowledge Exchange Workshop: Integrating the social and biological* KEW April 12th 2013 Training workshop: Life Course Research* ** Training workshop Monday 17 March 2014 Successful cohort leadership and management* ** Training workshop Friday 16 May 2014
 
Description CLOSER briefed the Lords prior to a debate on the latest research
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact Briefed the Lords prior to a debate on the latest research. Baroness Walmsley (who secured the debate) highlighted the main finding (disadvantaged children more likely to be affected) in her opening address and a number of other Peers alluded to it in their speeches. Letter was also written to Rob Davis, CLOSER, from the chair of health and social committee acknowledging that more info could be sent on the topic in the future and that it would be of use to them
 
Description CLOSER work feature in Childhood Obesity Strategy
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description CLOSER workshop Comparing Data Across and Within Longitudinal Studies: Challenges, Opportunities and Resources
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Increased awareness and understanding of Comparing Data Across and Within Longitudinal Studies: Challenges, Opportunities and Resources
 
Description Citation of CLOSER work in annual report of the chief medical officer
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description NICE Menopause Guidelines
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description NICE Menopause Guidelines
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Presentation for evidence week. Houses of Parliament. Organised by Sense about Science, the House of Commons Library, Parliamentary Office of Science and Technology and House of Commons Science and Technology Committee
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description RH expert advisor
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The guideline aims to improve the consistency of support and information provided to women in menopause.
URL https://www.nice.org.uk/guidance/ng23
 
Description RH speaker and panel member at Parliamentary seminar on childhood obesity
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Research visit to Faculty of Medicine, Universitas Gadjah Mada (UGM) in Yogyakarta, Indonesia and held manuscript writing workshop
Geographic Reach Asia 
Policy Influence Type Influenced training of practitioners or researchers
Impact workshop improved grant writing skills of researchers - paper published with collaborators
 
Description CLOSER innovation award - Scoping existing dietary data
Amount £133,323 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2018 
End 06/2018
 
Description MRC Career Development Award How will the obesity epidemic influence healthly ageing
Amount £811,514 (GBP)
Funding ID MR/P020372/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2017 
End 09/2022
 
Description UCL Global Engagement Award
Amount £2,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 06/2017
 
Title Body size deposited at UK Data Services 
Description The harmonised Height, Weight and BMI which were generated as part of CLOSER has been deposited with the UK Data Service. Cohort and Longitudinal Studies Enhancement Resources. (2017). Harmonised Height, Weight and BMI in Five Longitudinal Cohort Studies: MRC National Survey of Health and Development: Special Licence Access. [data collection]. UK Data Service. SN: 8209, http://doi.org/10.5255/UKDA-SN-8209-1 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Too early to caluclate the impact of adding these data to the UK Data Service. We do not know the number of times this data has been downloaded. 
URL https://discover.ukdataservice.ac.uk/series/?sn=2000111
 
Description BBSRC/ESRC Epigenetics network Bristol 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of NSHD data, advice, analysis, writing papers
Collaborator Contribution Contribution of other data, advice, analysis, writing papers
Impact Abstracts submitted
Start Year 2016
 
Description BIRTH TO TWENTY COHORT STUDY, SOUTH AFRICA 
Organisation Loughborough University
Department Centre for Global Health and Human Development
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration started when a new CDF joined us in 2013. He had previously had this collaboration in his previous job. Contributions include data analysis, publication writing and editing manuscripts.
Collaborator Contribution Contributions include data analysis, publication writing and editing manuscripts.
Impact 23876525
Start Year 2016
 
Description BIRTH TO TWENTY COHORT STUDY, SOUTH AFRICA 
Organisation University of the Witwatersrand
Country South Africa 
Sector Academic/University 
PI Contribution Collaboration started when a new CDF joined us in 2013. He had previously had this collaboration in his previous job. Contributions include data analysis, publication writing and editing manuscripts.
Collaborator Contribution Contributions include data analysis, publication writing and editing manuscripts.
Impact 23876525
Start Year 2016
 
Description BORN IN BRADFORD STUDY, UK 
Organisation Bradford Institute for Health Research (BIHR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration started when a new CDF joined us in 2013. He had previously had this collaboration in his previous job. Contributions include data analysis, publication writing and editing manuscripts.
Collaborator Contribution Contributions include data analysis, publication writing and editing manuscripts.
Impact 23940713
Start Year 2013
 
Description Calibration Study/University of Southampton 
Organisation Economic and Social Research Council
Country United Kingdom 
Sector Public 
PI Contribution The NSHD has carried out a calibration study of spirometers and blood pressure monitors used in various cohort studies. NSHD staff have carried out these assessments and are coordinating the project.
Collaborator Contribution The funding for this project was provided by the CLOSER research programme innovation fund through the ESRC. A PhD student enrolled at University of Southampton working with TNS/MDG has helped to coordinator the project and carry out the assessments. They will be writing up the results as part of their PhD.
Impact All the volunteers have been seen Researcher has registered for a PhD Oral presentation at European Survey Research Association, Lisbon 19 July 2017
Start Year 2015
 
Description Calibration Study/University of Southampton 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution The NSHD has carried out a calibration study of spirometers and blood pressure monitors used in various cohort studies. NSHD staff have carried out these assessments and are coordinating the project.
Collaborator Contribution The funding for this project was provided by the CLOSER research programme innovation fund through the ESRC. A PhD student enrolled at University of Southampton working with TNS/MDG has helped to coordinator the project and carry out the assessments. They will be writing up the results as part of their PhD.
Impact All the volunteers have been seen Researcher has registered for a PhD Oral presentation at European Survey Research Association, Lisbon 19 July 2017
Start Year 2015
 
Description Cardiovascular Collaboration with AH at UCL 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis of data, expertise and advice, grant applications, contributing to papers
Collaborator Contribution Analysis of data, expertise and advice, grant applications, contributing to papers
Impact Paper resubmitted
Start Year 2014
 
Description Cardiovascular biomarker Genetics collaboration 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing
Collaborator Contribution Analysis and interpretation of NSHD data Contribute to the scientific development of the collaboration Preparation of research papers
Impact Angelakopoulo PMID 21804106
Start Year 2012
 
Description Collaboration with Bristol LOK CV and menopause 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis, interpretation, drafting and revision of papers. Provide life course expertise and supervision of research project
Collaborator Contribution Analysis, interpretation, drafting and revision of papers.
Impact Research visit at LHA O'Keeffe, LM, Kuh, D, Fraser, A, Howe, LD, Lawlor, DA, Hardy, R. Age at period cessation and trajectories of cardiovascular risk factors across mid and later life. Heart. 2020 Feb 25. pii: heartjnl-2019-315754. doi: 10.1136/heartjnl-2019-315754. [Epub ahead of print] Second paper in progress
Start Year 2016
 
Description Collaboration with DB IOE 
Organisation University College London
Department Institute of Education (IOE)
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis, interpretation, drafting and revision of papers.
Collaborator Contribution Analysis, interpretation, drafting and revision of papers.
Impact Bann PMID 28072856 Socioeconomic Inequalities in Body Mass Index across Adulthood: Coordinated Analyses of Individual Participant Data from Three British Birth Cohort Studies Initiated in 1946, 1958 and 1970 Bann, D, Johnson, W, Li, L, Kuh, D, Hardy, R. Socioeconomic inequalities in body mass index, weight, and height in childhood and adolescence: coordinated analyses of individual participant data from four British birth cohort studies initiated in 1946, 1958, 1970, and 2000/1. Lancet Public Health 2018 Apr;3(4):e194-e203. doi: 10.1016/S2468-2667(18)30045-8. Epub 2018 Mar 21. Paper on social inequalities in blood pressure submitted. Paper on social inequalities in mortality in progress.
Start Year 2016
 
Description Collaboration with JD and AH UCL Cardio 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributions will include providing NSHD data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include using NSHD data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact PMID 25198238 24856161 25246483 Servier Award - European research proposal in the field of hypertension and related diseases with a focus on end-organ damage and other biomarkers.
Start Year 2009
 
Description Collaboration with Loughborough University WJ 
Organisation Loughborough University
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysis, interpretation, drafting and revision of papers. Life course epidemiology and statistical expertise
Collaborator Contribution Analysis, interpretation, drafting and revision of papers.
Impact Collaborator/steering group member on grant application to NIRG. Funded March 2017 Supervisor on PhD project LHA hosted Loughborough PhD student, Ellie Robson, for 3 weeks in April 2018 Johnson, W, Bann, D, Hardy, R. Rapid infant weight gain and adolescent obesity: comparison across two United Kingdom cohorts born in 1946 and 2001. Is the positive relationship of rapid infant weight gain with adolescent body mass index accentuated in obesogenic environments? Archives of Disease in Childhood.Archives 2018 Oct;103(10):974-980. doi: 10.1136/archdischild-2017-314079 Robson, E, Wulaningsih, W, Norris, T, Hamer, M, Hardy, R, Johnson, W. The relationship of early-life adversity with adulthood weight and cardiometabolic health status in the 1946 National Survey of Health and Development. Psychosomatic Medicine 2020 Jan;82(1):82-89. doi: 10.1097/PSY.0000000000000751. paper in press: Johnson, W, Norris, T, Bann, D, Cameron, N, Wells, JK, Cole, TJ, Hardy, R. Differences in the relationship of weight to height, and thus the meaning of BMI, according to age, sex, and birth year cohort. Annals of Human Biology. 2 papers in progress Norris, T, Bann, D, Hardy, R, Johnson, W. Socioeconomic inequalities in childhood-to-adulthood BMI tracking in three British birth cohorts. International Journal of Obesity. 2020 Feb;44(2):388-398. doi: 10.1038/s41366-019-0387-z.
Start Year 2015
 
Description Collaboration with National Cancer Institute, NIH 
Organisation National Cancer Institute (NCI)
Country United States 
Sector Public 
PI Contribution Data analysis, expertise, contributing to research papers
Collaborator Contribution Data analysis, expertise, contributing to research papers
Impact PMID 26930450 Zhou
Start Year 2015
 
Description Collaboration with TC Institute of Child Health 
Organisation University College London
Department Institute of Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating on a recently obtained grant developing and applying the SITAR method of growth curve analysis for translational exposures and life course outcomes in human growth assessment. We initially plan to relate the derived parameters to genetic obesity-risk-allele scores and subsequently to health outcomes. Providing NSHD data and expertise Help with drafting and revision of papers.
Collaborator Contribution Data analysis, interpretation, drafting and revision of papers. Providing methodological expertise.
Impact Funding for grant application - Developing and applying the SITAR method of growth curve analysis for translational exposures and life course outcomes in human growth assessment.
Start Year 2012
 
Description Collaboration with Universitas Gadjah Mada 
Organisation Gadjah Mada University
Country Indonesia 
Sector Academic/University 
PI Contribution Collaboration on joint projects on cancer and obesity. Data analysis and research paper writing. Sharing of good practice and delivery of grant writing workshop
Collaborator Contribution Collaboration on joint projects on cancer and obesity. Data analysis and research paper writing.
Impact Research visit to Indonesia and grant writing workshop Paper published Anwar SL, Tampubolon G, Van Hemelrijck M, Hutajulu SH, Wulaningsih W. Determinants of cancer screening awareness and participation among Indonesian women. BMC Cancer 2018 18:208. DOI: 10.1186/s12885-018-4125-z.
Start Year 2017
 
Description ESCAPE 
Organisation Utrecht University
Country Netherlands 
Sector Academic/University 
PI Contribution Provide NSHD and epidemiological experitise
Collaborator Contribution Prof Bert Brunkekfreef leads a FP7 collaboration qith 25 collaborating groups. Enhancing NSHD with geocoding of residential histories and linking them to ari polution levels.
Impact Enhancing NSHD with contextual data from geocoding. Adams et al PMID: 25193994 Schikowski et al PMID: 24488569 Cai et al PMID: 25112730
Start Year 2008
 
Description Eating behaviours and cardiometabolic outcomes with HNR 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributions will include providing data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Collaborator Contribution Contributions will include providing data, data analysis, research advice, publication writing, grant applications, editing manuscripts and knowledge exchange
Impact PMID 24357571
Start Year 2013
 
Description External Programme co led by CVD Project Management Group 
Organisation Sahlgrenska University Hospital
Country Sweden 
Sector Hospitals 
PI Contribution Providing the data from the NSHD, data analysis and writing up results
Collaborator Contribution CVD PMG was established for the purpose of maximising the scientific potential of the NSHD data on cardiac and vascular structure and function
Impact 21804106, 21909115
Start Year 2008
 
Description External Programme co led by CVD Project Management Group 
Organisation St George's University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing the data from the NSHD, data analysis and writing up results
Collaborator Contribution CVD PMG was established for the purpose of maximising the scientific potential of the NSHD data on cardiac and vascular structure and function
Impact 21804106, 21909115
Start Year 2008
 
Description External Programme co led by CVD Project Management Group 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing the data from the NSHD, data analysis and writing up results
Collaborator Contribution CVD PMG was established for the purpose of maximising the scientific potential of the NSHD data on cardiac and vascular structure and function
Impact 21804106, 21909115
Start Year 2008
 
Description External Programme co led by CVD Project Management Group 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing the data from the NSHD, data analysis and writing up results
Collaborator Contribution CVD PMG was established for the purpose of maximising the scientific potential of the NSHD data on cardiac and vascular structure and function
Impact 21804106, 21909115
Start Year 2008
 
Description FALCon - Function Across the Life Course 
Organisation Medical Research Council (MRC)
Department MRC Social & Public Health Sciences Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Rebecca Hardy is PI on this PHSRN funded project "Measurement and Modelling of Function Across teh Life Course". Diana Kuh is a co-investigator and LHA has a scientist funded by this project. LHA leads on the measurement aspect of the project, leading a systematic review and analysis of multiple datasets. MRC Biostatistics scientist regularly visits LHA to discuss more complex modelling where she is supervised by rebecca Hardy.
Collaborator Contribution FALCon investigator. Lead the modelling component of FALConFALCon InvestigatorFALCon InvestigatorFALCon Investigator
Impact Two abstracts. Two systematic review papers submitted. Other papers in preparation
Start Year 2008
 
Description FALCon - Function Across the Life Course 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology
Country United Kingdom 
Sector Academic/University 
PI Contribution Rebecca Hardy is PI on this PHSRN funded project "Measurement and Modelling of Function Across teh Life Course". Diana Kuh is a co-investigator and LHA has a scientist funded by this project. LHA leads on the measurement aspect of the project, leading a systematic review and analysis of multiple datasets. MRC Biostatistics scientist regularly visits LHA to discuss more complex modelling where she is supervised by rebecca Hardy.
Collaborator Contribution FALCon investigator. Lead the modelling component of FALConFALCon InvestigatorFALCon InvestigatorFALCon Investigator
Impact Two abstracts. Two systematic review papers submitted. Other papers in preparation
Start Year 2008
 
Description FALCon - Function Across the Life Course 
Organisation University of Cambridge
Department MRC Biostatistics Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Rebecca Hardy is PI on this PHSRN funded project "Measurement and Modelling of Function Across teh Life Course". Diana Kuh is a co-investigator and LHA has a scientist funded by this project. LHA leads on the measurement aspect of the project, leading a systematic review and analysis of multiple datasets. MRC Biostatistics scientist regularly visits LHA to discuss more complex modelling where she is supervised by rebecca Hardy.
Collaborator Contribution FALCon investigator. Lead the modelling component of FALConFALCon InvestigatorFALCon InvestigatorFALCon Investigator
Impact Two abstracts. Two systematic review papers submitted. Other papers in preparation
Start Year 2008
 
Description FALCon - Function Across the Life Course 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Rebecca Hardy is PI on this PHSRN funded project "Measurement and Modelling of Function Across teh Life Course". Diana Kuh is a co-investigator and LHA has a scientist funded by this project. LHA leads on the measurement aspect of the project, leading a systematic review and analysis of multiple datasets. MRC Biostatistics scientist regularly visits LHA to discuss more complex modelling where she is supervised by rebecca Hardy.
Collaborator Contribution FALCon investigator. Lead the modelling component of FALConFALCon InvestigatorFALCon InvestigatorFALCon Investigator
Impact Two abstracts. Two systematic review papers submitted. Other papers in preparation
Start Year 2008
 
Description FALCon cohort collaborators 
Organisation Medical Research Council (MRC)
Department MRC Social & Public Health Sciences Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data from NSHD and research expertise
Collaborator Contribution Provided data from other cohort studies and research expertise and advice
Impact PMID 20829298,20843964,20042875,21695075, 22249241,20843964,24770853
Start Year 2008
 
Description FALCon cohort collaborators 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data from NSHD and research expertise
Collaborator Contribution Provided data from other cohort studies and research expertise and advice
Impact PMID 20829298,20843964,20042875,21695075, 22249241,20843964,24770853
Start Year 2008
 
Description FALCon cohort collaborators 
Organisation University of Cambridge
Department MRC Biostatistics Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data from NSHD and research expertise
Collaborator Contribution Provided data from other cohort studies and research expertise and advice
Impact PMID 20829298,20843964,20042875,21695075, 22249241,20843964,24770853
Start Year 2008
 
Description FALCon cohort collaborators 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided data from NSHD and research expertise
Collaborator Contribution Provided data from other cohort studies and research expertise and advice
Impact PMID 20829298,20843964,20042875,21695075, 22249241,20843964,24770853
Start Year 2008
 
Description FELS LONGITUDINAL STUDY, USA 
Organisation University of Minnesota
Department Division of Epidemiology and Community Health
Country United States 
Sector Academic/University 
PI Contribution One of our CDFs collaborates with Minnesota to work on research projects using the Fels Longitudinal Study. The CDF used to work at Minnesota and this collaboration has continued since moving to the UK and starting work at the Unit. Contributions include data analysis, publication writing and editing manuscripts.
Collaborator Contribution Contributions include data analysis, publication writing and editing manuscripts.
Impact 23794238 23719556 24081233 23606227
Start Year 2013
 
Description Genetics of obesity 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing, analysis, scientific papers
Collaborator Contribution Nick Wareham's group has brought genetic experitise to collaboration
Impact 22456663 22654120 22150704 20962026 19880856 25198238
Start Year 2008
 
Description HALCyon 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation Newcastle University
Department Institute for Ageing and Health
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University College London
Department Institute of Education (IOE)
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University of Bristol
Department School of Social and Community Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University of Portsmouth
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description HALCyon 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA is responsible for managing the HALCyon grant and also organising conferences and meetings for researchers. NSHD data sharing and epideomiological expertise is also provided.
Collaborator Contribution Provided data and research guidance
Impact numerous papers including 23437142
Start Year 2008
 
Description INTERNATIONAL HEALTH INSTITUTE, BROWN UNIVERSITY, USA. 
Organisation Brown University
Department International Health Institute
Country United States 
Sector Academic/University 
PI Contribution Collaboration started when a new CDF joined us in 2013. He had previously had this collaboration in his previous job. Contributions include data analysis, publication writing and editing manuscripts.
Collaborator Contribution Contributions include data analysis, publication writing and editing manuscripts.
Impact None to report this year
Start Year 2013
 
Description Infant Feeding Study collaboration 
Organisation University College London
Department Institute of Epidemiology and Health Care
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborated on research papers. Provide expertise and advise on manuscripts
Collaborator Contribution Data analysis and creation of manuscripts
Impact Research publications
 
Description Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution UCL is the main partner for this collaboration NSHD data sharing, revision of manuscripts
Collaborator Contribution Analysis and interpretation of NSHD (and other) data Contribute to the scientific development of the collaboration Preparation of research papers
Impact PMID 22421340
Start Year 2011
 
Description International Consortium for Blood Pressure Genome-wide Association 
Organisation Queen Mary University of London
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing, data analysis and contributing to writing of research papers
Collaborator Contribution Coordinating the consortium, providing data and genetics expertise
Impact Numerous research papers 21378095 22100073 21909115
Start Year 2009
 
Description Life course methods collaboration with McGill 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Data analysis and manuscript preparation
Collaborator Contribution Data analysis and manuscript preparation
Impact Madathil, S, Joseph, L, Hardy, R, Rousseau, M-C, Nicolau, BA. Bayesian approach to investigate life course hypotheses involving continuous exposures. International Journal of Epidemiology. 2018 Oct 1;47(5):1623-1635. doi: 10.1093/ije/dyy107.
Start Year 2017
 
Description Lung function collaboration WW JA 
Organisation Imperial College London
Department Imperial College Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Analysis, interpretation, drafting and revision of papers. Life course epidemiology expertise.
Collaborator Contribution Analysis, interpretation, drafting and revision of papers. Respiratory expertise.
Impact Allinson 2016 PMID: 26695373 The Presence of Chronic Mucus Hypersecretion Allinson JP 2017 Combined Impact of Smoking and Early-Life Exposures on Adult Lung Function Trajectories. PMID: 28530117 First paper led to setting up of new UK cohort.This is a collaboration between six UK academic centres in collaboration with the British Lung Foundation and with multiple international industry partners. Based upon the NSHD research, industry and the academic centres are pursuing our hypotheses about early COPD development. Paper 1 has been cited >30 times already, and both paper 1 and paper 2 feature within the prestigious 2018 GOLD (Global Obstructive Lung Disease) Document. Allinson JP, Hardy R, Donaldson GC, Wedzicha JA. Childhood Exposures, Asthma, Smoking, Interactions and the Catch-Up Hypothesis. Ann Am Thorac Soc. 2018 Jul 26. doi: 10.1513/AnnalsATS.201807-444LE. [Epub ahead of print] Further papers in progress BRC Grant award £17,764: Linking early life exposures to adult respiratory mortality
Start Year 2015
 
Description Novel risk markers for CVD disease 
Organisation St George's University of London
Department Division of Population Health Sciences and Education
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing - early life exposure data from the cohort database Provision of data on cardiac indices in support of the analysis Advise on analyses taking life course exposures into account. Contribute to the scientific development of the project throughout.
Collaborator Contribution Responsible for overall management of the project, planning of analyses and will supervise the study statistician in conjunction with the other investigators. Drafting of study reports in conjunction with co-investigators. Provision of data on cardiac indices in support of the analysis. Provision of data on vascular indices in support of the analysis. Provision of data on laboratory measurements in support of the analysis.
Impact Grant funding from MRC Grant funding now finished 2016 Papers being completed Elhakeem A. Leisure-time physical activity across adulthood and biomarkers of cardiovascular disease at age 60-64: a prospective cohort study. PMID:29180005 Elhakeem, A, Cooper, R, Whincup, P, Brage, S, Kuh, D, Hardy, R. Physical activity, sedentary time and cardiovascular disease biomarkers at age 60-64. JAHA. 2018 Aug 21;7(16):e007459. doi: 10.1161/JAHA.117.007459. Erratum in: J Am Heart Assoc. 2018 Oct 16;7(20):e004284. PMID: 30369324
Start Year 2011
 
Description Novel risk markers for CVD disease 
Organisation University College London
Department Department of Cardiorespiratory Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing - early life exposure data from the cohort database Provision of data on cardiac indices in support of the analysis Advise on analyses taking life course exposures into account. Contribute to the scientific development of the project throughout.
Collaborator Contribution Responsible for overall management of the project, planning of analyses and will supervise the study statistician in conjunction with the other investigators. Drafting of study reports in conjunction with co-investigators. Provision of data on cardiac indices in support of the analysis. Provision of data on vascular indices in support of the analysis. Provision of data on laboratory measurements in support of the analysis.
Impact Grant funding from MRC Grant funding now finished 2016 Papers being completed Elhakeem A. Leisure-time physical activity across adulthood and biomarkers of cardiovascular disease at age 60-64: a prospective cohort study. PMID:29180005 Elhakeem, A, Cooper, R, Whincup, P, Brage, S, Kuh, D, Hardy, R. Physical activity, sedentary time and cardiovascular disease biomarkers at age 60-64. JAHA. 2018 Aug 21;7(16):e007459. doi: 10.1161/JAHA.117.007459. Erratum in: J Am Heart Assoc. 2018 Oct 16;7(20):e004284. PMID: 30369324
Start Year 2011
 
Description Novel risk markers for CVD disease 
Organisation University of Glasgow
Department Institute of Cardiovascular and Medical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing - early life exposure data from the cohort database Provision of data on cardiac indices in support of the analysis Advise on analyses taking life course exposures into account. Contribute to the scientific development of the project throughout.
Collaborator Contribution Responsible for overall management of the project, planning of analyses and will supervise the study statistician in conjunction with the other investigators. Drafting of study reports in conjunction with co-investigators. Provision of data on cardiac indices in support of the analysis. Provision of data on vascular indices in support of the analysis. Provision of data on laboratory measurements in support of the analysis.
Impact Grant funding from MRC Grant funding now finished 2016 Papers being completed Elhakeem A. Leisure-time physical activity across adulthood and biomarkers of cardiovascular disease at age 60-64: a prospective cohort study. PMID:29180005 Elhakeem, A, Cooper, R, Whincup, P, Brage, S, Kuh, D, Hardy, R. Physical activity, sedentary time and cardiovascular disease biomarkers at age 60-64. JAHA. 2018 Aug 21;7(16):e007459. doi: 10.1161/JAHA.117.007459. Erratum in: J Am Heart Assoc. 2018 Oct 16;7(20):e004284. PMID: 30369324
Start Year 2011
 
Description SABRE collaboration - genetic and epigenetic characterisation 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Enhancing and extending characterisation of the SABRE cohort Sharing of NSHD data and epidemiological expertise Member of Executive Group - provide advice as required Help with preparation of manuscripts
Collaborator Contribution We aim to explain ethnic differences in susceptibility to cardiometabolic disease. Enhancing and extending characterisation of the SABRE cohort Data analysis and intepretation Manuscript preparation and submission
Impact Submission of a grant application Grant application funded
Start Year 2012
 
Description Spirometa genentic collaboration 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution Data sharing, genotyping and analysis
Collaborator Contribution Martin Tobin led the spirometa consortium to investigate the genetics of lung function
Impact 21946350 21965014 20010834
Start Year 2009
 
Description Tilling Epigenetic Collaboration Bristol 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide life course epidemiology expertise, assisting with data analysis and preparation of manuscripts
Collaborator Contribution Provide life course epidemiology and epigenetics expertise, assisting with data analysis and preparation of manuscripts
Impact Grant application funded by BBSRC/ESRC
Start Year 2016
 
Description UCLEB cohort collaboration for genetic research 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing and epideomiological experitise
Collaborator Contribution Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing
Impact UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436
Start Year 2008
 
Description UCLEB cohort collaboration for genetic research 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing and epideomiological experitise
Collaborator Contribution Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing
Impact UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436
Start Year 2008
 
Description UCLEB cohort collaboration for genetic research 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution NSHD data sharing and epideomiological experitise
Collaborator Contribution Maximising research potential of NSHD Prof Aroon Hinorani brings in CVD and genetic skills and manages the collaboration with several CVD cohort studies at UCL and Edinburgh, including NSHD. Data sharing
Impact UCL Biomedical Research Centre High Impact Grant awarded BHF programme grant under review 23977022 White 26781229 Neusch 25979724 Talmund 25475436
Start Year 2008
 
Description Universitas Gadjah Mada (UGM) in Yogyakarta 
Organisation Gadjah Mada University
Country Indonesia 
Sector Academic/University 
PI Contribution LHA will provide expertise on life course approach, cohort management and data analysis.
Collaborator Contribution Universitas Gadjah Mada will organise local training and collaboration activities which engage LHA and UGM researchers.
Impact Research visited planned for May 2017
Start Year 2016
 
Description leap 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution LHA scientists are co-supervising an Imperial student investigating the effects of air polution on cardiovascualr morbidity in NSHD.
Impact Enhancing NSHD by creating residential histories for study members and linking these data to air polution data publications eventually.
Start Year 2009
 
Description 72nd birthday card workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Two workshops were held with ~20 school students (year 9 and year 13) to discuss the history of cohort studies and why they are important. Students were then asked to design a birthday card for our study members using collage. They used old memorabilia from the study. This was a collaboration between a collage artist and two historians from LSHTM. A number of birthday cards were created and two were chosen to send to our study members. As a result of this collaboration a research paper about the history of the NSHD is in progress as well as another public engagement event.
Year(s) Of Engagement Activity 2017
 
Description Article in Health Management publication 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Article in a health management publication. Hardy R. A life course approach to cardiovascular ageing. Health Management, 2015; 15: 35-37.
Year(s) Of Engagement Activity 2015
 
Description City and Islington Academy Career Fair (BTEC students) 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact City and Islington Academy Career Fair (BTEC students) 2017 (2x): career fair with presentations to around 80 students in small groups about what a job as a researcher is like and the research conducted at LHA (body size and metabolomics) which sparked inquisitive responses.
Year(s) Of Engagement Activity 2017
 
Description Editor's Choice paper in the European Heart Journal. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Increased awareness of NSHD research
Year(s) Of Engagement Activity 2014
 
Description Green Man 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Green Man 2018 - As part of this, with funding from MRC, researchers from UCL partnered with fanSHEN theatre company to create an activity to engage the public with findings from longitudinal life course research.
The successful collaboration led to the development of "Life Course golf course"; part crazy golf, part insight into research from longitudinal cohort studies. In this activity, festival goers were recruited into the life course-themed six-hole golf course. Their caddy (research scientists) navigated them through the 'life course golf course' by discussing and describing how studying birth cohorts have helped us to understand how early life factors can affect later health outcomes.
Over 1,500 adults and children successfully progressed through the course. With an audience made up of families, teenagers and adults who wouldn't normally attend a scientific event, it presented a fantastic opportunity to share about our research in a fun and creative way.
We have had lots of positive feedback and have been approached by other universities and even the Science Museum to explore re-running the activity at future events
Year(s) Of Engagement Activity 2018
URL https://www.ucl.ac.uk/cardiovascular/research/population-science-and-experimental-medicine/mrc-unit-...
 
Description Green Man Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Green Man Festival. Scientists from the Medical Research Council Unit for Lifelong Health and Ageing at UCL wanted to tell people all about their work- a UK birth cohort study of 5000 people who have been studied by the unit ever since they were born in 1946.

Funded by the Wellcome Trust, artists helped to transform the study into 'Tangle', an activity designed to represent how scientists gather up the threads of many people's lives and weave them together to answer research questions. Festival goers were asked to contribute their data on eight variables the scientists examine, for example stress, memory, and health behaviours. Instead of filling out questionnaires, the participants got a piece of coloured fabric for each of their answers, which they wound onto a rope to create their "life course". Anything else that they thought was important in their lives they wrote onto a fabric luggage tag to share with everyone.

More than 600 people came to talk to the scientists and make their own life course, which they then used to help answer a research question: "What is most important to your quality of life." Against the backdrop of Welsh mountains a tapestry frame stood displaying various answers such as, "health", "wealth" and "music" (well, it was a music festival). The new study members threaded their own life course into the section that represented them. It soon became obvious what was most important to their quality of life.
Year(s) Of Engagement Activity 2017
 
Description HALCYon Project Summary Brochure 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A plain english brochure was created which summarised the main findings from the HALCyon research programme. It has been disseminated to study members, on our website and the New Dynamics of Ageing website and at conferences.

Increased awareness of the findings from the HALCyon programme and the cohorts that were used within this research programme
Year(s) Of Engagement Activity 2014
 
Description HALCYon book launch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact A book launch was arranged to promote the findings from the HALCyon research programme

Shared knowledge of the HALCyon findings which were published in a book 'A life course approach to healthy ageing'.
Year(s) Of Engagement Activity 2014
 
Description Hammersmith Academy Career Event (year 7-9) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Hammersmith Academy Career Event (year 7-9) 2017: school visit involving a mock interview to around 100 students in small groups and highly interactive discussions on working as a researcher, its scope of work, the type of research and career trajectories.
Year(s) Of Engagement Activity 2017
 
Description Holloway School Career Event 2017: mock interview 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Holloway School Career Event 2017: mock interview to small groups of students to help them to be more familiar with job seeking situations and develop employability
Year(s) Of Engagement Activity 2017
 
Description MRC Festival of Medical Research 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Science Fair in South Cloisters with MRC LMCB and MRC Prion Unit. Our stall used a modified Green Man 2017 "Tangled"
Year(s) Of Engagement Activity 2018
URL http://www.nshd.mrc.ac.uk/news-events/recent-news/mrc-festival-2018-blog/
 
Description Media Interest (Charakida) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Media interest about a paper looking at the impact of lifelong patterns of weight change on cardiovascular risk factors


Awareness raised of the impact of longer term weight gain on cardiovascular health
Year(s) Of Engagement Activity 2014
 
Description Media interest in 'Child obesity risk increases almost three-fold in five generations'. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Media interest in 'Child obesity risk increases almost three-fold in five generations'. Increased awareness of NSHD research and CLOSER research programme.
Year(s) Of Engagement Activity 2015
 
Description NDA findings brochure 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The New Dynamics of Ageing programme which funded the HALCyon programme created a findings document summerising the results of the HALCyon programme which was distributed to their local networks

Increased awareness of the HALCyon findings and a life course approach to healthy ageing. Increased awareness of longitudinal studies and the cohorts that were involved in HALCyon
Year(s) Of Engagement Activity 2014
 
Description NSHD 70th birthday events and media interest 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The department organised two birthday events for our study members in London and Manchester. The parties gained significant media attention (print and feature on BBC news). The study member feedback was also very positive and the events were seen as a success.

Health Study - why we owe so much to the class of '46, The Observer
BBC News at 10, Tuesday 1st March
BBC Breakfast short version, Wednesday 2nd March
BBC Inside Science, Thursday 3rd March
The Naked Scientists, Monday 7th March
A video of the London event was created by Dreaming Fish on behalf of the MRC.
The NSHD also featured on a number of local BBC radio stations on Wednesday 1st March.
BBC Radio Cambridgeshire
MRC Network Magazine
MRC Life Magazine
MRC Sound Cloud https://soundcloud.com/the_mrc/mrc-talks-episode-7
Sunday People http://www.mirror.co.uk/news/uk-news/douglas-babies-who-helped-shape-7634768
http://news.xinhuanet.com/english/2016-03/05/c_135159132.htm
Study member interviewed on Radio Stoke 4 March 2016 14:26
Year(s) Of Engagement Activity 2016
 
Description New story on MRC website about Einstein's garden at Green Man Festival 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact News story on the MRC public engagement section of their website detailing the activity we took part in for the Green Man Festival
Year(s) Of Engagement Activity 2017
 
Description News coverage of CLOSER work "Children from lower social classes up to 5kg heavier than their more advantaged peers, new study finds" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The story was covered in a large number of papers, including:
The Times - Poor children 2kg heavier than rich
Daily Telegraph - Poor children in Britain now matter more than wealthy in dramatic reversal
Daily Mail - How children have lost the war on weight
The Sun - SCHOOL OF LARD KNOCKS. Poorer kids now fatter than those from richer
Daily Express - Child obesity: How children lost the war on weight
Daily Star: Poor people are fatter than rich people - and this is the reason
Daily Mirror
Metro
Boots WebMD - Inequalities in kids' weight reversed
RT - A sign of the times? Poor children officially fatter than rich kids, study proves
Talk Radio - Lunchtime show, David Bann interviewed by George Galloway
Year(s) Of Engagement Activity 2018
 
Description News story by the Guardian about public health expenditure and mortality in older adults 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact News story by the Guardian about public health expenditure and mortality in older adults
Year(s) Of Engagement Activity 2017
 
Description Podcast for 'Child of our Time' blog post about the PloS Medicine obesity paper. 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Podcast for 'Child of our Time' blog post about the PloS Medicine obesity paper. Increased awareness of NSHD research.
Year(s) Of Engagement Activity 2015
 
Description Presentation at American Heart Association conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Health professionals
Results and Impact Director invited to give a presentation

A life course approach to cardiovascular health

Professors Diana Kuh and Rebecca Hardy
MRC Unit for Life Course Health and Ageing at UCL

American Heart Association
17th November 2013
Dallas Texas


Promoting life course approach to cardiovascular ageing to cardiac health professionals
Year(s) Of Engagement Activity 2013
 
Description Press release on Health and social care spending cuts since 2010 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press release on piece of research about health and social care spending cuts since 2010 are linked to nearly 120,000 excess deaths in England, with the over 60s and care home residents most affected. Article picked up by the Guardian https://www.theguardian.com/commentisfree/2017/nov/17/austerity-minorities-women-disabled
Year(s) Of Engagement Activity 2017
URL http://www.ucl.ac.uk/news/news-articles/1117/161117-austerity-deaths-england
 
Description STEM workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact STEM workshop to inform students about careers in STEM areas. Feedback from the students said the stand provided very helpful information and that the majority were interested in a STEM career.
Year(s) Of Engagement Activity 2017
 
Description Ted Talk by Helen Pearson about The Life Project 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Scientists at the Unit contributed to Helen Pearson's book 'The Life Project'. Helen gave a talk featureing the NSHD for TED. It has had 1,649,889 views and has increased the awareness of the NSHD and longitudinal research.
Year(s) Of Engagement Activity 2017
URL https://www.ted.com/talks/helen_pearson_lessons_from_the_longest_study_on_human_development
 
Description Walthamstow Women's Day Celebration (Year 9) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Walthamstow Women's Day Celebration (Year 9) 2017 and 2018: school visit involving quiz and a brief talk to showcase diverse careers for women to around 150 students which sparks questions and generated positive responses
Year(s) Of Engagement Activity 2013,2017,2018