1958 cohort-sample management

Lead Research Organisation: University of Bristol

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

To physically relocate DNA samples to Bristol and curate samples for 2 years. Including quality control and management of associated genotype and phenotype data .||The British 1958 birth cohort is based on all persons born in Britain during one week in March in 1958. Participants have been followed throughout their lives and biomedical information has been collected at various time points. DNA and cell line banks have been established in Bristol and at other locations. This funding will allow all DNA samples from the cohort to be held in the same laboratory in Bristol and made available to 2ry users from there, subject to oversight arrangements. Funding request includes governance and maintenance of the DNA and cell line banking facilities. The related genotype data will also be held in Bristol, including quality control data.

Publications

10 25 50

 
Title 1958 biomedical resource 
Description DNA, cell lines and biosamples collected during the 1958 biomedical sweep. Genotyping data obtained from these samples 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Since the purpose of this grant was to make samples and data freely available to the scientific community for research projects we have also liaised with numerous researchers who have used the resource both in this country and internationally. Over the course of the grant there were 26 DNA sample shipments and 26 linked genotype and phenotype data requests. Since the grant ended the management of the resource was covered by finding from grant G1001799 (PI Prof Paul Burton) from 2011 to 2015 and is currently covered by grant 108439/Z/15/Z Biomedical Resources Grant, 58FORWARDS (The 1958 Birth Cohort: Fostering new Opportunities for Research via Wider Access to Reliable Data and Samples) PI Professor Paul Burton. Details of current collaborations for the 1958 biomedical resource are documented in the return for the current grant 
URL http://www.metadac.ac.uk/data-access-through-metadac/
 
Title 1958 birth cohort biomedical resource data 
Description Genetics and other data generated from samples collected during the biomedical sweep for the 1958 birth cohort 
Type Of Material Database/Collection of data 
Year Produced 2006 
Provided To Others? Yes  
Impact Data has been made available for a number of international projects which results in around 70 new publications per annum. The resource supports a broad range of biomedical research, with new uses emerging with new bioscience and technological developments. which fall into the following categories (1) A national source of uncharacterised population-based controls for genomic studies (cases obtained elsewhere), primarily genotyping data from the cohort is obtained via the Wellcome Trust Case COntrol COnsortium. (2) A national source of population-based controls for non-genomic biomedical studies (cases obtained elsewhere). (3) A source of characterised cases and controls for biomedical studies. (4) A source of data and biosamples for exploring the aetiological determinants of quantitative traits. (5) A source of genotypes linked to phenotypes for exploring the aetiological architecture of common complex diseases. 6) Contribution to consortium-based analyses involving harmonization with other biobanks and co-analysis. Since the grant ended the management of the resource was covered by finding from grant G1001799 (PI Prof Paul Burton) from 2011 to 2015 and is currently covered by grant 108439/Z/15/Z Biomedical Resources Grant, 58FORWARDS (The 1958 Birth Cohort: Fostering new Opportunities for Research via Wider Access to Reliable Data and Samples) PI Professor Paul Burton. Details of current collaborations for the 1958 biomedical resource are documented in the return for the current grant 
URL http://www.metadac.ac.uk/data-access-through-metadac/
 
Description 1958 birth cohort 
Organisation University College London
Department 1958 Birth Cohort/National Child Development Study
Country United Kingdom 
Sector Academic/University 
PI Contribution This grant was a resource grant for the 1958 and as such the samples and data have been used by many users. Since the grant ended the management of the resource was covered by finding from grant G1001799 (PI Prof Paul Burton) from 2011 to 2015 and is currently covered by grant 108439/Z/15/Z Biomedical Resources Grant, 58FORWARDS (The 1958 Birth Cohort: Fostering new Opportunities for Research via Wider Access to Reliable Data and Samples) PI Professor Paul Burton. Details of current collaborations for the 1958 biomedical resource are documented in the return for the current grant
Collaborator Contribution see above
Impact see above
Start Year 2006
 
Description 1958 participants 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Research findings from the study are publicised to participants via the study team responsible for maintaining contact with the cohort at the Institute of Education, University College London. There is a participant website (http://www.ncds.info/default.asp) which includes details of press releases and media coverage related to the study.



Encourages participation in future data collection exercises
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,
URL http://www.cls.ioe.ac.uk/page.aspx?&sitesectionid=724&sitesectiontitle=National+Child+Development+St...