The MRC ConDuCT-II Hub. COllaboration and iNnovation in DiffiUlt and Complex randomised controlled Trials In Invasive procedures

Lead Research Organisation: University of Bristol
Department Name: Social Medicine

Abstract

The ConDuCT-II Hub is based within the School of Social and Community Medicine, at the University of Bristol and is led by Professor Blazeby, Professor of Surgery. It will include a multi-disciplinary group of academics with established track records in the development of better ways for designing and conducting research to evaluate healthcare interventions. The work will focus on creating new methods and improving existing methods to undertake randomised controlled trials. Randomised controlled trials usually compare two new or standard treatments. The importance of a randomised controlled trial is that patients participating in them could be allocated to either of the procedures under evaluation by a process of randomisation. This means that the patients have an equal chance of having either procedure and so a fair comparison of the outcomes of each of them can be made. These types of studies are the most valid and reliable means of evaluating healthcare interventions, and there is a need for better ways of conducting the trials to inform health policy and practice. There is a particular lack of well designed and conducted randomised controlled trials in surgery and invasive healthcare procedures which means that practice is not based on evidence and standards of surgery and similar invasive procedures vary across the country and within the NHS.

The research will be undertaken by four interlinked themes. The themes include: (1) trial prioritisation and design, (2) trial recruitment, (3) feasibility study design and trial conduct, and, (4) outcome assessment, reporting and integration into decision-making. Each theme is underpinned by expertise in statistics and qualitative methods and there are close links to practising clinicians and the two clinical trials units in Bristol, the Bristol Randomised Trials Collaboration and the Clinical Trials and Evaluation Unit. The Hub has additional collaborations with the regional and national registered clinical trials units and other MRC Hubs. The ConDuCT-II Hub will build on these relationships and with new relationships with the Royal College of Surgeons of England Surgical Trials Centres (in Bristol, Oxford, Birmingham and Manchester/Liverpool). The ConDuCT-II Hub will also develop international links to surgeons and methodologists worldwide by providing innovative methods to optimise the conduct of trials in surgery and by provision of specialist training. The ConDuCT-II Hub will undertake methodological research and it will integrate innovative methods into new feasibility studies and full trials in surgery and invasive procedures.

The ConDuCT-II Hub will also deliver a training programme for clinicians and other scientists in study design and methods to optimise the design and delivery of complex healthcare interventions and trials in surgery. These courses will also be relevant to trials of public healthcare and primary care interventions. These are similar to surgical interventions because they include multiple components within each intervention, that influence outcomes by acting both together and separately. The training programme will provide an apprenticeship to create a new generation of clinicians who understand and practice evidence based medicine. The new methods will be implemented in new trials and this will lead to evidence to inform healthcare decision-making at policy and practice level. It is anticipated that the ConDuCT-II Hub will ultimately lead to a sustainable change in research culture and it will allow more and even better trials to be developed to answer critical questions of relevance to patients and the NHS.

Technical Summary

The ConDuCT-II Hub is based within the School of Social and Community Medicine, at the University of Bristol and led by Blazeby, Professor of Surgery. It will build on the achievements of the ConDuCT Hub to develop the Hub into a world class centre of excellence for high-quality, cutting-edge methodological research of relevance to pragmatic randomised controlled trials (RCTs) in general, but with a particular focus on the needs of RCTs in surgery. Within the Hub there will be four interlinked research themes. The themes include: (1) trial prioritisation and design, (2) trial recruitment, (3) feasibility study design and trial conduct, and, (4) outcome assessment, reporting and integration into decision-making. Each theme is underpinned by expertise in statistics and qualitative methods and there are close links to practising clinicians and the two registered clinical trials units (CTUs) in Bristol. The Hub has regional and national collaborations with other registered CTU and MRC Hubs and it will develop new relationships with the Royal College of Surgeons of England Surgical Trials Centres and international collaborations with surgical trials centres in continental Europe and North America by providing innovative methods to optimise the conduct of trials in surgery and by provision of specialist training. The Hub will deliver a training programme for clinicians and methodologists in specialists areas to optimise the design and delivery of complex healthcare interventions and trials in surgery. The Hub will integrate new and improved methods into new trials in collaboration with regional and national CTUs working closely with clinicians (especially surgeons). The combination of new methods, training courses, workshops and apprenticeship opportunities offered by the Hub will lead to more and better trials to be developed to answer critical questions of relevance to patients and the NHS.

Planned Impact

The research, training and work undertaken by the ConDuCT-II Hub will impact policy makers, health care innovators, scientists nationally and internationally, clinicians and patients. The Hub will develop and improve methods to undertake randomised controlled trials (RCTs) that will lead to marked improvements in the successful design, conduct and completion of pragmatic RCTs in all areas but particularly in surgery.
Policy makers (such as the National Institute for Heath and Clinical Excellence, NICE) will benefit because the Hub will carry out methodological research to improve the commissioning, design and conduct of RCTs of non-pharmaceutical and invasive interventions. Currently the NICE Interventional Procedures Committee reviews selected invasive procedures and makes recommendations on uptake but it is often limited by the lack of high quality RCTs in this area. The Hub, therefore, by improving the number and quality of trials will directly provide evidence for review by this committee.

The Hub will also impact on clinicians who develop innovative practice in complex non-pharmaceutical interventions. Currently this is performed within strict regulations which is risky and is likely to have led to the introduction of interventions into clinical practice which are at best an ineffective and inefficient use of resources and at worst could have serious but unrecognised side effects. In the ConDuCT-II hub new methods will be developed to study complex invasive healthcare interventions and to introduce them into practice. It will impact on clinicians by working with them to gain funding to allow safe and more controlled evaluations of new interventions. Similarly work in the Hub will impact on clinical trialists in the UK and internationally who will use the methods and implement them into new studies.

A major theme in the Hub will focus upon methods to improve the selection and implementation of outcomes in trials. The Hub will develop methods to improve the content and validity of 'core outcome sets'. The use of core outcome sets will impact several key stakeholders because it will allow data synthesis from trials to inform policy makers (e.g. NICE) and scientists (e.g. in meta-analyses) and importantly it will provide the core information for clinicians to communicate to patients regarding the trial results. In ConDuCT-II methods for clinicians to communicate the core information will be developed and tested. This will improve health professionals' satisfaction with the consultation process and it is expected that better information provision will reduce litigation and complaints and more satisfied patients.

The ConDuCT-II will also impact by its training courses on clinicians and trainees and methodologists. The courses will focus on best methodologies for RCTs of non-pharmaceutical interventions, and especially surgery. This will build future capacity through training methodologists and clinicians via new short courses and provision of both clinical and non-clinical PhD studentships. Up to five clinicians will have the opportunity for a clinical research taster for six months within the Hub during which they will be supported to develop and write a full research training fellowship application. The methodologically trained clinicians will then become future leaders and academics in this field to pursue the vision of the Hub and change the culture in surgery such that practice can become based on evidence and so standards of care across the UK can be developed.

Organisations

Publications

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Al-Janabi H (2016) A Framework for Including Family Health Spillovers in Economic Evaluation. in Medical decision making : an international journal of the Society for Medical Decision Making

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Alfirevic Z (2016) Methods to induce labour: a systematic review, network meta-analysis and cost-effectiveness analysis. in BJOG : an international journal of obstetrics and gynaecology

 
Title Investigating the effect of treatment preferences on recruitment and retention to paediatric trials. 
Description Poster produced by Beasant for Research without Borders Exhibition, Bristol. The primary audience were students and the geographical reach was local. 
Type Of Art Artwork 
Year Produced 2016 
Impact Not aware of any 
 
Title OPTIMA (Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis): A prospective trial to validate the predictive utility and cost-effectiveness of gene expression test-directed chemotherapy decisions 
Description Francis, Adele; Stein, Robert C.; Marshall, Andrea; Rea, Daniel W.; Cameron, David A.; Macpherson, Iain R.; Earl, Helena M.; Poole, Christopher J.; Hall, Peter S.; Bartlett, John M.S.; Rooshenas, Leila; Morgan, Adrienne; Harmer, Victoria; Donovan, Jenny; Hulme, Claire; McCabe, Christopher; Pinder, Sarah E.; Hughes-Davies, Luke; Makris, Andreas; Dunn, Janet A. Poster presented for Association of Breast Surgery (abstract published in: European Journal of Surgical Oncology, Vol. 42, No. 5, 09.04.2016, p. S9-S10.) in Manchester. The primary audience were professional practitioners and the geographical reach was national. 
Type Of Art Image 
Year Produced 2016 
Impact Not aware of any 
 
Title The treatment preferences of adolescents and their parents, what has the smile RCT shown us? SMILE: specialist medical intervention and lightning evaluation 
Description A poster produced by Beasant, L, Mills, N. & Crawley, E. for the 3rd International Clinical Trials Methodology Conference & Trials. 2015 in Glasgow. The primary audience were professional practitioners and the geographical reach was national. 
Type Of Art Artwork 
Year Produced 2015 
Impact Not aware of any 
 
Description Abstract Committee, Cochrane abstract committee
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Advice to HRB-TMRN QUESTS team regarding their project on the development and evaluation of a RCT recruiter training intervention
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Advisory committee: Designing a service model to promote the mental health and well-being of children in Cambridgeshire and the East of England
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description Amber Young Appointed as trustee to Childrens Burns Trust
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Awards Committee, Cochrane Thomas Chalmers Awards committee
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Chair TSG - REACH Pregnancy Programme
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Chair of Advisory Group - MRC/NIHR Methodology Research Programme
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Chris Rogers member of steering committee - Health Foundation
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Chris Rogers, Oversight committee, DMC, NIHR HTA
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Citation of co-authored paper [Hopkins et al, 2015] in systematic review
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
 
Description Citation of first author paper [Coulman et al, 2013] in three systematic reviews
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
 
Description Co-Director
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Cochrane Multiple Interventions Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Cochrane Scientific Committee
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Cochrane Trainees, Committee member, Natalie Blencowe
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Committee member, Diabetes UK Clinical Studies Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description DMC Chair: Women Offenders Repeat Self-Harm Intervention
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description DMC, Trial Governance, IntAct:Intraoperative Fluorescence sngiography to prevent colorectal anastomotic leak
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description DMC, Trial Governance, Minimally invasive thoracoscopically-guided right minithoracotomy versus conventional sternotomy for mitral valve repair: a multicentre randomised controlled trial (UK Mini Mitral)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description DMC: Scandinavian Prostate Cancer Group Trial #17: Prostate Cancer Active Surveillance Trigger Trial (PCASTT),
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Data Monitoring Committee - LORIS Trial
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Data Monitoring Committee - PD_STAT study
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Data Monitoring Committee - TOPPOTS trial
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Director for the NICE Clinical Guidelines Technical Support Unit
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Editorial Board Member - Health Expectations Editorial
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Editorial Board of the NIHR Trial Managers network Trial Mangement Guide
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
Impact This group prepared the 'Guide to Efficient Trial Management' 2014. Impact is projected/expected. " (Athene Lane)
URL http://www.nihr.ac.uk/documents/about-NIHR/NIHR-Publications/Trial-managers-network-guidelines.pdf
 
Description Education Committee of the 4th International Clinical Trials Methodology Conference and the Society for Clinical Trials 38th Annual Meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Elliott D, Lead facilitator, MRC HTMR Recruitment Working group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Expert Advisory Group member for the Irish Health Information and Quality Authority (HIQA) Health Technology Assessment of Smoking Cessation Interventions
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Expert Panel - NCRI Future of Surgery
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Governance Committee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Grant Committee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Grant Committee - Bowel Cancer UK grant committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee - NIHR HTA Comissioning Board
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Grant Committee - NIHR Health Services and Delivery Research Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee - NIHR Public Health Research Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee - NIHR RfPB South West
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee - PHIND
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee - RfPB SW Panel member
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee, Medical Research Council (MRC) Clinical Training and Career Development Panel, Jane Blazeby
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee, NIHR Fellowship Programme Reviews Panel for Career Development, Senior and Transitional Research Fellowships, Jane Blazeby
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee, NIHR Senior Investigator Appointment Panel
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee, NIHR-HTA, Chris Rogers
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Grant Committee, Ordinary member of the Executive Committee of the International Society of Clinical Biostatistics
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Grant committee - NIHR Research Methods Funding Board
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Grant committee, MRC Public Health Intervention Development (PHIND) Scheme Funding Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant committee, Member of the NIHR Clinical Trials Units Standing Advisory Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant committee, Member, South West Region Advisory Committee for the NHS Research for Patient Benefit (RfPB) funding scheme
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant committee, NIHR Research Methods Fellowships and Internships Expert Review Panel member
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant committee, NIHR Research Methods Fellowships and Internships and NIHR Systematic Review Fellowships
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant committee, Society of Clinical Trials Board nominating committee, Jane Blazeby
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Grant committee, South West RfPB
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Grant committee, Trials Methodology Research Network Studies within a Trial Call 2016, Irish Health Research Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Grant reviewing
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description InterTASC workshop presentation (N Welton)
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description JB - Dragon's Den at AUGIS Annual Scientific Meeting this year - training event for surgical trials.
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.augis.org.uk/brighton2014/
 
Description JB on TSC - UKUFF TSC - meeting on 14/05/14
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
URL https://viis.abdn.ac.uk/HSRU/UKUFF/Site/Public/Default.aspx
 
Description Kerry Avery - member of formal working group, otcomes working group for new MRC Trials Methodology Research Partnership
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description MAST - Clinician
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MAST - DISC RCT
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description MAST - DISC RCT
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description MAST - Sabine van der Veer
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MAST, Karen Spencer (Univeristy of Manchester)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description MAST, MRC HTMR Trial Conduct Working Group member, Athene Lane
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MAST, Requested training/advice on improving recruitment to difficult RCT, Tim Davis (Queen's Medical Centre, Nottingham)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MAST, Trial Conduct Working Group member, Clare Clement
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MAST: Qualitative advice given to Oxford team developing grant application for a trial of different surgical co-interventions for brain tumour resection.
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description MRC Hubs for Trials Methodology Network
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Member TSG - Healthy Dads, Healthy Kids UK
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Member and Chair of Expert Panel - DIFA
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Member of British Journal of Surgery Council
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Member of Consensus Group - MRC/NIHR Methodology Reseacrch Programme Exploratory Trials Guidance
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Member of MRC HTMR Network Summit and Expert Panel on the integration of quantitative and qualitative data findings in clinical trials
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Member of NIHR Senior Investigators Appointment panel
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Member of Research Advisory panel - Macmillan Cancer Support
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Member of TSG. Project on development and evaluation of an RCT recruiter training intervention
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Member of Trial Steering Committee: SPRING (PI Robin Grant, NIHR HTA)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Member of UKCRC clinical trial units network Core Infrastructure & Resources task and finish group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NICE Service Guidance Methods Expert Working Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NICE Technology Appraisals Cancer Drugs Fund Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NIHR CLAHRC West Research Advisory Panel, Chair, Tim Peters
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description NIHR Complex Reviews Support Unit Advisory/Governance Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NIHR Fellowship Programme Review Panel for Career Development, Senior Research and Transitional Research Fellowships
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NIHR Senior Investigator Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NIHR research - Making the most of your methodologists
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Nicola Mills, MAST, Advice on publication and consideration of further data collection
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Nicola Mills, MAST, Advice on qualitative methodology within an RCT
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Nicola Mills, MAST, Advice on recruiting patients to surgical trials
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Nicola Mills, MAST, Advice on training recruiters to research studies
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Overall project lead and lead of the randomisation methods working group.
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Oversight Committee, Data Monitoring Committee, NIHR-HTA funded UK Mini Mitral, Chris Rogers
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Oversight Group of the NIHR Trial Managers Network: 2011-2014
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Pat Hoddinott, Chair of TSC, NIHR HTA16/143/01- FROSTTIE: A randomized controlled trial of FRenotomy and breastfeeding support Or breastfeeding Support without frenotomy to investigate continuation of breastfeeding for babies with Tongue TIE.
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Pat Hoddinott, grant funding committee, HTA Commissioning Board
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Pat Hodinott, member of TSC, Evaluation of the outcomes of the Family Nurse partnership Programme in Scotland. . Funded by Scottish Government.
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description PhD external examiner
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Reproduction of 'Distress Thermometer and Problem List
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Research Committee member, Vascular Society if Great Britain & Ireland
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Research Committee of the 4th International Clinical Trials Methodology Conference and the Society for Clinical Trials 38th Annual Meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Rhiannon Macefield, member of formal working group, National Wound Care Strategy Programme - member of the surgical workstream and and research enabler workstream
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Rooshenas L, Jepson M, Paramasivan S, Other, Advice on recruitment feedback session for RADAR trial RADAR NIHR HTA
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description SCREESCO Trial Steering Committee
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description Sangeetha Paramasivan, MAST, Advice and potential involvement from a Methodology and QoL perspective for a proposed breast implant RCT
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Sangeetha Paramasivan, MAST. Request for potential collaborators for a HTMR proposal on ethnic minority groups' understanding of patient information leaflets
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Scientific Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Scientific Committee member - Wounds Research Network (WReN)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Scientific Programme Committee - ISCBC
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Scientific reference group to the NHS Prostate Cancer Risk Management programme. AL
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Summit and Expert Panel on mixed Methods - MRC HTMR Hubs Network
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC Chair
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC Chair, MACRO: Defining best management for adults with chronic rhinosinusitis. NIHR Programme Grants for Applied Research (PGfAR) RP-PG-0614-20011
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC Chair, PARCS: Patch Augmented Rotator Cuff Surgery Study- A feasibility study. NIHR HTA Programme
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC Chair, Trial Governance, GAPS Trial
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC Chair, Trial Governance, LaCes feasibility: A multicentre, randomised controlled feasibility trial of laparoscopic versus open colorectal surgery in the acute setting. NIHR RfPB
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC Chair, Trial Governance, PulMiCC Trial
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC member, Trial Governance, A realist process evaluation of robotic surgery. NHS NIHR, Health Services and Delivery Research programme
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description TSC member, Trial Governance, MIDFUT Trial
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial Govenance, Trial Steering Committee, Hughes Abdominal Repair Trial (PI Jared Torkington, NIHR HTA)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Trial Governance, Clinical and cost-effectiveness of progressive exercise compared to best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: a 2x2 factorial randomised controlled trial (The GRASP trial)
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Trial Governance, Trial Steering Committee, PACE trial (PI Chris Butler, NIHR HTA)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Trial Governance: PARCS: Patch Augmented Rotator Cuff Surgery Study- A feasibility study.
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial Governance: Thermal Abalation versus surgery for patients with colorectal liver metastases. The LAVA trial
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial Management Group: SMALL
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Trial Management Working Group (co-lead)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial Steering Committee - BRAVO study
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial Steering Committee - HALT-IT
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial Steering Committee - the GRASP Trial
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial Steering Committee, DISCHARGE (PI Marc Dewey, EU FP7)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Trial Steering committee, OPTCARE Neuro (PI Irene Higginson, NIHR HS & DS)
Geographic Reach South America 
Policy Influence Type Participation in a advisory committee
 
Description Trial governance committee, Data Monitoring Committee, NIHR-EME funded IntAct trial, Chris Rogers
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Trial governance, High risk bladder cancer: A randomised controlled feasibility study of radical cystectomy against intra-vesical immunotherapy (BRAVO)
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Trial governance, Nicola Wiles, Data Monitoring Committee, NIHR HTA funded VIP trial (PI: M Serfaty, UCL)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Trial governance, Nicola Wiles, Trial Steering Committee, NIHR HTA funded TOSCA trial (PI: Buszewicz, UCL)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Trial governance, SCREESCO, a Swedish National trial, funded by government, of the cost-effectiveness of colorectal cancer screening in the Swedish context
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Trial governance, Simvastatin as a neuroprotective treatment for Parkinson's Disease: a double-blind, randomised, placebo controlled futility study in patients of moderate severity (PD-STAT)
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Trial governance, TSC, HAND-1 feasibility study
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial governance, TSC/PSC, INFORM Programme (including qualitative and trial workstreams)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Trial steering committee: The ECASS Study: Evaluation of a Computer Aid for assessing Stomach Problems
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Working Group to update MRC Complex Intervention Guidelines
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description "Qualitative Ancillary Study: Understanding and optimising recruitment to the TARVA trial TARVA: Total Ankle Replacement Versus Arthrodesis"
Amount £14,515 (GBP)
Funding ID HTA - 12/35/27 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2017 
End 10/2017
 
Description A RCT to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with MRCP in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones:
Amount £2,857,515 (GBP)
Funding ID HTA/16/142/04 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2018 
End 05/2024
 
Description A RCT to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with MRCP in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones:
Amount £2,857,515 (GBP)
Funding ID HTA/16/142/04 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2018 
End 05/2024
 
Description A Randomised Controlled Trial to investigate the clinical and cost-effectiveness of Paravertebral Blockade compared with Thoracic Epidural Blockade in reducing Chronic Post-Thoracotomy Pain (TOPIC 2)
Amount £1,661,405 (GBP)
Funding ID HTA/16/111/111 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2018 
End 10/2022
 
Description A Randomised Trial of Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC)
Amount £15,693 (GBP)
Funding ID 19399 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2016 
End 09/2016
 
Description A clinical effectiveness investigation of a multi-faceted intervention (incorporating a prognostic algorithm) to improve management of antibiotics for CHIldren presenting to primary care with acute COugh and respiratory tract infection (CHICO): an effic
Amount £826,831 (GBP)
Funding ID 16/31/98 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description A feasibility study and pilot RCT to establish methods for assessing the acceptability, and clinical and cost-effectiveness of enhanced psychological care (EPC) in cardiac rehabilitation services for patients with new onset depression compared with treatm
Amount £448,291 (GBP)
Funding ID HTA - 12/189/06 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 04/2014 
End 07/2016
 
Description A multicentre randomised controlled trial of splint duration for mallet injuries (MALIT)
Amount £11,570 (GBP)
Organisation British Association of Plastic Reconstructive and Aesthetic Surgeons 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 05/2016
 
Description A network meta-analysis of complex interventions to prevent mental-ill-health in children and young people: evaluation of effective and cost-effective intervention components
Amount £350,079 (GBP)
Funding ID 15/49/08 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2016 
End 06/2018
 
Description A phase 3 trial of Rivastigmine to prevent falls in Parkinson's Disease
Amount £2,545,636 (GBP)
Funding ID HTA/16/31/13 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2017 
End 12/2021
 
Description A pragmatic multicentre randomised controlled trial to assess the clinical and cost effectiveness of negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention (SWHSI 2)
Amount £1,631,171 (GBP)
Funding ID HTA/17/42/94 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2022
 
Description A pragmatic multicentre randomised controlled trial to assess the clinical and cost effectiveness of negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention (SWHSI 2)
Amount £1,631,171 (GBP)
Funding ID HTA/17/42/94 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2022
 
Description A prospective multicentre cohort study to inform the feasibility and conduct of a pragmatic randomised clinical trial comparing new techniques of implant based breast reconstruction (iBRA study)
Amount £221,363 (GBP)
Funding ID PB-PG-0214-33065 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 01/2015 
End 12/2017
 
Description A prospective multicentre cohort study to inform the feasibility and conduct of a pragmatic randomised clinical trial comparing new techniques of implant based breast reconstruction (iBRA study)
Amount £221,363 (GBP)
Funding ID PB-PG-0214-33065 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 01/2015 
End 12/2017
 
Description A randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of laparoscopic cholecystectomy compared with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated sy
Amount £1,397,962 (GBP)
Funding ID HTA/14/192/71 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 04/2016 
End 04/2021
 
Description A randomised controlled trial of Partial prostate Ablation versus Radical prosTatectomy (PART) in intermediate risk unilateral clinically localised prostate cancer a feasibility study
Amount £655,011 (GBP)
Funding ID HTA 12/35/54 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 01/2015 
End 01/2017
 
Description A randomised controlled trial on the effectiveness of GP promotion of e-cigarettes in supporting reduced smoking and abstinence in hardcore smokers with smoking-related chronic disease (ERASE).
Amount £308,980 (GBP)
Funding ID PDF-2016-09-043 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2018
 
Description A randomised controlled trial on the effectiveness of GP promotion of e-cigarettes in supporting reduced smoking and abstinence in hardcore smokers with smoking-related chronic disease (ERASE).
Amount £308,980 (GBP)
Funding ID 333 
Organisation Scottish School of Primary Care 
Department Scottish Primary Care Research Network (SPCRN)
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2018
 
Description A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with MRCP in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common
Amount £2,900,000 (GBP)
Funding ID 16/142/04 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 06/2018 
End 05/2024
 
Description A systematic review of the assessment of implementation fidelity in primary care trials
Amount £50,546 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2016 
End 02/2017
 
Description A woman-centred, tailored SMS-delivered multi-component intervention for weight loss and maintenance of weight loss in the postpartum period: intervention adaptation and pilot RCT
Amount £483,040 (GBP)
Funding ID PHR/14/67/20 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2016 
End 08/2018
 
Description ACTION 330: A cluster randomised feasibility trial evaluation of a teaching assistant led, extracurricular physical activity intervention for 8 to 10 year olds.
Amount £507,782 (GBP)
Funding ID 15/55/09 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 09/2017
 
Description Academy of Medical Sciences Starter grants for clinical lecturers
Amount £20,336 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 10/2016
 
Description Adaptation of evidence-informed complex population health interventions for implementation and/or re-evaluation in new contexts: New guidance
Amount £320,261 (GBP)
Funding ID MR/R013357/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 08/2020
 
Description Advancing the integration of mixed methods in clinical trials: a two day summit
Amount £9,950 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Hubs for Trial Methodology Research
Sector Public
Country United Kingdom
Start 12/2016 
End 07/2017
 
Description Antidepressants to prevent relapse in depression
Amount £1,668,027 (GBP)
Funding ID HTA/13/115/48 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 09/2015 
End 09/2019
 
Description Antidepressants to prevent relapse in depression
Amount £1,668,027 (GBP)
Funding ID HTA/13/115/48 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description Antidepressants to prevent relapse in depression.
Amount £1,668,027 (GBP)
Funding ID HTA - 13/115/148 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description Aspirin for Venous Ulcers: Randomised Trial (AVURT)
Amount £500,000 (GBP)
Funding ID 13/87/08 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 11/2014 
 
Description Assets-based feeding help Before and After birth (ABA): feasibility study for improving breastfeeding initiation and continuation.
Amount £328,980 (GBP)
Funding ID 15/53/04 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2016 
End 10/2018
 
Description BASIL-2: Bypass vs. Angioplasty in Severe Ischaemia of the Leg-2
Amount £2,000,000 (GBP)
Funding ID HTA 12/35/45 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 05/2014 
 
Description Basil-3: BAlloon vs Stenting in Severe Ischaemia of the Leg-3
Amount £2,000,000 (GBP)
Funding ID 13/81/02 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2015 
 
Description Biomedical Research Centre
Amount £4,500,000 (GBP)
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Bristol Biomedical Research Centre - Surgical Innovation Theme
Amount £2,020,517 (GBP)
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Bristol Surgical Trials Centre
Amount £500,000 (GBP)
Organisation Royal College of Surgeons of England 
Sector Learned Society
Country United Kingdom
Start  
 
Description CITED RCT of a community intervention for late life depression in Brazil (Araya)
Amount £11,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2014 
End 06/2015
 
Description CONservative TReatment of Appendicitis in Children a randomised controlled Trial CONTRACT (Feasibility study)
Amount £444,985 (GBP)
Funding ID HTA - 14/192 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description CONservative TReatment of Appendicitis in Children a randomised controlled Trial CONTRACT (Feasibility study)
Amount £482,882 (GBP)
Funding ID HTA - 14/192/90 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 07/2016 
End 05/2019
 
Description Calibration of absolute and relative treatment effects using individual patient data: Matching-adjusted Indirect Comparisons (MAIC) and Simulated Treatment Comparisons (STC) in Technology Appraisals.
Amount £18,000 (GBP)
Funding ID 214133 
Organisation National Institute for Health and Care Excellence (NICE) 
Sector Public
Country United Kingdom
Start 03/2016 
End 08/2016
 
Description Calibration of multiple treatment comparisons using individual patient data. MRC Methodology Research Panel.
Amount £308,461 (GBP)
Funding ID MR/P015298/2 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2019
 
Description Calibration of multiple treatment comparisons using individual patient data. MRC Methodology Research Panel.
Amount £308,461 (GBP)
Funding ID MR/P015298/2 
Organisation Medical Research Council (MRC) 
Department MRC/NIHR Methodology Research Programme
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2019
 
Description Children's drops for ear pain in acute otitis media: the CEDAR randomised controlled trial
Amount £1,377,900 (GBP)
Funding ID HTA/13/88/13 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 01/2015 
End 12/2015
 
Description Choice of moisturiser for eczema (COMET).
Amount £435,403 (GBP)
Funding ID PB-PG-0712-28056 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 10/2013 
End 06/2015
 
Description Chronic pain after total knee replacement: better post-operative prevention and management (the STAR Programme)
Amount £100,937 (GBP)
Funding ID RP-DG-1211-10002 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 09/2020
 
Description Cluster randomised controlled trial (RCT) for late life depression in socioeconomically deprived areas of São Paulo, Brazil (PROACTIVE)
Amount £522,570 (GBP)
Funding ID MR/R006229/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 06/2021
 
Description Cluster randomised controlled trial (RCT) for late life depression in socioeconomically deprived areas of Sao Paulo, Brazil (PROACTIVE).
Amount £1,104,894 (GBP)
Funding ID MR/R006229/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description Core Outcomes for Burn Care Research: short-term outcomes and outcome measures for use in burn care efficacy trials. MRC/Wellcome Trust Joint Global Health Trials Initiative and FAPESP
Amount £140,000 (GBP)
Organisation Scar Free Foundation 
Start 10/2018 
End 10/2021
 
Description DRIFT - follow up (Luyt)
Amount £300,000 (GBP)
Funding ID HTA/12/35/61 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 09/2014 
End 05/2016
 
Description Developing a medical work force to design and conduct trials to improve evidence-based practice: a case study of surgical Trainee Research Collaboratives and a stakeholder workshop (ReSurgEnT)
Amount £49,969 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Human Nutrition Research Unit
Sector Public
Country United Kingdom
Start 12/2016 
End 12/2017
 
Description Developing a new composite outcome measure for cardiac surgery trials
Amount £53,178 (GBP)
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Developing, delivering and evaluating training courses for recruiters to randomised trials
Amount £36,962 (GBP)
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 08/2015
 
Description Development of a SPIRIT-PRO Extension: Delphi survey consensus meeting and publication
Amount £55,000 (GBP)
Organisation Macmillan Cancer Support 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 12/2017
 
Description Development of a central resource for research in recruitment in clinical trials (ORCCA database)
Amount £90,261 (GBP)
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 08/2016
 
Description Development of a multilevel and mixture-model framework for modelling epigenetic changes over time 
Amount £296,416 (GBP)
Funding ID MR/M025020/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 07/2018
 
Description ETTAA QRI
Amount £11,036 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Hubs for Trial Methodology Research
Sector Public
Country United Kingdom
Start 10/2017 
End 10/2020
 
Description Effectiveness, cost efectiveness and safety of gabapentin versus placebo as an adjunct to multimodal pain regimens in surgical patients: A placebo controlled randomised controlled trial with blinding (The GAP study)
Amount £1,139,565 (GBP)
Funding ID HTA - 15/101/16 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description Efficient sample schemes for estimation of value of information of future research. MRC Network of Hubs for Trials Methodology Research.
Amount £34,756 (GBP)
Funding ID N79 
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2021
 
Description Evaluating new models of care for people with long term conditions (Salisbury)
Amount £1,769,619 (GBP)
Organisation National Institute for Health Research 
Department Health Services and Delivery Research (HS&DR) Programme
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 05/2017
 
Description Examining the influence of an informational video on participant retention in a randomised controlled trial.
Amount £9,051 (GBP)
Organisation Irish Health Research Board 
Sector Charity/Non Profit
Country Ireland
Start 05/2017 
End 05/2018
 
Description Exploring patient perspectives of recruitment in randomised controlled trials
Amount £117,882 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Hubs for Trial Methodology Research
Sector Public
Country United Kingdom
Start 10/2017 
End 10/2020
 
Description Exploring strategies for implementing core information sets for informed consent to surgery for head and neck cancer: operationalising Montgomery
Amount £30,000 (GBP)
Funding ID SGL018\1002 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Extending ORRCA to create a central resource for retention research within clinical trials (ORRCA 2)
Amount £40,830 (GBP)
Funding ID N101 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis (FREE-IA): A Feasibility Study for a Randomised Controlled Trial
Amount £248,079 (GBP)
Funding ID PB-PG-1216-20014 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2018 
End 05/2020
 
Description Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis (FREE-IA): A Feasibility Study for a Randomised Controlled Trial
Amount £248,039 (GBP)
Funding ID PB-PG-1216-20014 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2020
 
Description Feasibility study of how best to engage obese men in narrative SMS (short message system) and incentive interventions for weight loss, to inform a future effectiveness and cost-effectiveness trial
Amount £490,970 (GBP)
Funding ID PHR/14/185/09 
Organisation National Institute for Health Research 
Department Public Health Research (PHR) Programme
Sector Charity/Non Profit
Country United Kingdom
Start 06/2016 
End 08/2018
 
Description Full Randomised Controlled Trial of Arthroscopic Surgery for Hip Impingement versus best Conventional care UK FASHIoN 2
Amount £1,727,557 (GBP)
Funding ID HTA - 13/103/02 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 04/2014 
End 02/2020
 
Description Gastric Bypass, adjustable gastric Banding or Sleeve gastrectomy surgery to treat severe and complex obesity: a multi-centre randomised controlled trial
Amount £3,939,934 (GBP)
Funding ID HTA - 09/127/53 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 07/2015 
End 07/2018
 
Description Guidance to optimise pilot study design and conduct: HTMR and NIHR HTA 'Research on Research' proposal
Amount £13,280 (GBP)
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 11/2016 
End 09/2017
 
Description Guidance to optimise pilot study design and conduct: A joint HTMR and NIHR HTA 'Research on Research' proposal
Amount £30,596 (GBP)
Funding ID N85 
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 09/2016 
End 08/2017
 
Description Guided self-help for depression in adults with autism spectrum disorder
Amount £355,155 (GBP)
Funding ID HTA/14/43/02 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 03/2015 
End 03/2018
 
Description Guided self-help for depression in adults with autism spectrum disorder (ADEPT)
Amount £418,442 (GBP)
Funding ID HTA - 14/43/02 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 12/2015 
End 12/2018
 
Description H4RT: The High-volume Haemodiafiltration vs High-flux Haemodialysis Registry Trial.
Amount £747,882 (GBP)
Funding ID 15/80/52 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description HOD: Assessing risk of bias in non-randomized studies of interventions
Amount £635,652 (GBP)
Funding ID MR/M025209/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 02/2018
 
Description Health Economics Analysis Plans: developing content guidance through consensus
Amount £39,697 (GBP)
Funding ID N91 
Organisation Medical Research Council (MRC) 
Department MRC Hubs for Trial Methodology Research
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2018
 
Description Health Economics Analysis Plans: developing content guidance through consensus.
Amount £39,697 (GBP)
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 03/2018
 
Description Heath Technology Assessment
Amount £999,978 (GBP)
Funding ID HTA/14/192/109 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2016 
End 10/2021
 
Description How do smoking cessation medicines compare with respect to their neuropsychiatric safety: a systematic review, network meta-analysis and cost effectiveness analysis
Amount £261,107 (GBP)
Funding ID 5/58/18 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 09/2016 
End 08/2018
 
Description Identification of iems for inclusion in a standardised resource-use measure
Amount £19,612 (GBP)
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 02/2015 
End 01/2016
 
Description Identification of items for inclusion in a standardised resource-use measure (Thorn)
Amount £19,612 (GBP)
Organisation Medical Research Council (MRC) 
Department MRC Hubs for Trial Methodology Research
Sector Public
Country United Kingdom
Start 02/2015 
End 01/2016
 
Description Identifying and critiquing different approaches to developing complex interventions (INDEX study)
Amount £380,033 (GBP)
Funding ID MR/N015339/1 
Organisation Medical Research Council (MRC) 
Department MRC/NIHR Methodology Research Programme
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 03/2018
 
Description Identifying and critiquing different approaches to developing complex interventions (INDEX study).
Amount £380,463 (GBP)
Funding ID MR/N015339/1 
Organisation Medical Research Council (MRC) 
Department MRC/NIHR Methodology Research Programme
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2018
 
Description Impact of health on social and economic outcome: qualitative study.
Amount £449,973 (GBP)
Organisation Health Foundation 
Start 04/2018 
End 03/2021
 
Description Improving the design of RCT's in surgery: understanding how to describe and standardise co-interventions
Amount £26,250 (GBP)
Funding ID SGL013\1005 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2015 
End 08/2017
 
Description Improving the management of patients with multimorbidity in general practice
Amount £1,789,589 (GBP)
Funding ID 12/130/15 
Organisation National Institute for Health Research 
Department Health Services and Delivery Research (HS&DR) Programme
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 09/2017
 
Description Incorporating external evidence syntheses in the analysis of a clinical trial
Amount £71,628 (GBP)
Funding ID HTMR Q10 
Organisation Medical Research Council (MRC) 
Department MRC Hubs for Trial Methodology Research
Sector Public
Country United Kingdom
Start 10/2015 
End 03/2018
 
Description Inform: Infection after total joint replacement
Amount £2,012,256 (GBP)
Funding ID RP-PG-1210-12005 
Organisation National Institute for Health Research 
Department Programme Grants for Applied Research (PGfAR)
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Inform: Infection after total joint replacement.
Amount £825,000 (GBP)
Funding ID RP-PG-1210-12005 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Integrated therapist and online CBT for depression in primary care
Amount £2,233,801 (GBP)
Funding ID RP-PG-0514-20012 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2016 
End 03/2022
 
Description Integrated therapist and online CBT for depression in primary care
Amount £2,233,801 (GBP)
Funding ID RP-PG-0514-20012 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2016 
End 04/2022
 
Description Integrated therapist and online CBT for depression in primary care (INTERACT)
Amount £2,233,800 (GBP)
Funding ID RK7725 
Organisation National Institute for Health Research 
Department Programme Grants for Applied Research (PGfAR)
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Integrated therapist and online CBT for depression in primary care. (INTERACT)
Amount £2,233,801 (GBP)
Funding ID RP-PG-0514-20012. 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2016 
End 03/2022
 
Description Investigating the effectiveness and cost effectiveness of using FITNET to treat paediatric CFS/ME in the UK
Amount £999,977 (GBP)
Funding ID HTA 14/192/109 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2016 
End 10/2021
 
Description Investigating the treatment of paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME)
Amount £864,736 (GBP)
Funding ID SRF-2013-06-013 
Organisation National Institute for Health Research 
Department NIHR Fellowship Programme
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 10/2019
 
Description Investigating the treatment of paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) (MAGENTA RCT)
Amount £864,736 (GBP)
Funding ID SRF-2013-06-013 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2014 
End 01/2019
 
Description Long term follow up of patients in the COBALT (CBT for treatment resistant depression) trial
Amount £162,230 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2013 
End 08/2014
 
Description Losing the losses: understanding the reasons for attrition in RCTs and developing the evidence to prevent it
Amount £216,000 (GBP)
Funding ID MR/K024310/1 
Organisation Medical Research Council (MRC) 
Department MRC/NIHR Methodology Research Programme
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 12/2016
 
Description Low intensity interventions for antenatal depression: A feasibility study of an RCT of Interpersonal Counselling compared to Cognitive Behavioural Therapy.
Amount £241,934 (GBP)
Funding ID PB-PG-1216-20027 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2018 
End 12/2019
 
Description Low intensity interventions for antenatal depression: A feasibility study of an RCT of Interpersonal Counselling compared to Cognitive Behavioural Therapy.
Amount £245,672 (GBP)
Funding ID PB-PG-1216-20027 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2018 
End 05/2020
 
Description MALIT: A multicentre randomised controlled trial of splint duration for mallet injuries.
Amount £23,140 (GBP)
Organisation British Society for Surgery of the Hand (BSSH) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 04/2016
 
Description MASTER
Amount £20,099 (GBP)
Funding ID HTA/11/106/01 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2015 
End 01/2016
 
Description MASTER
Amount £20,099 (GBP)
Funding ID HTA/11/106/01 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2015 
End 11/2016
 
Description MICA: Model Based Network Meta-Analysis for Pharmacometrics and Drug-Development.
Amount £201,060 (GBP)
Funding ID MR/M005615/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC HTMR - Advancing training for health professionals and trialists to optimise RCT recruitment and informed consent
Amount £10,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 06/2019
 
Description MRC HTMR - IMPACT: Identification of items for inclusion in a standardised resource-use measure
Amount £4,286 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2018 
End 11/2019
 
Description MRC HTMR- MPACT: Health Economics Analysis Plans: developing content guidance through consensus
Amount £6,840 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 05/2019
 
Description MRC HTMR: Improving the evaluation of medical devices with development of a generic core outcome set: a key stakeholder workshop for industry, innovators, clinicians, trialists, journal editors and health policy makers
Amount £9,938 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 06/2019
 
Description MRC Network of Hubs for Trials Methodology Research
Amount £47,175 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 10/2018
 
Description MRC Network of Hubs for Trials Methodology Research:PhD studentships
Amount £92,088 (GBP)
Funding ID P5-2014-LB 
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 09/2018
 
Description MRC PhD studentship
Amount £53,178 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description MRC-NIHR MRP: Inferring relative treatment effects from combined randomised and observational data.
Amount £725,176 (GBP)
Funding ID MR/R025223/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2019 
 
Description Mesothelioma and Radical Surgery 2: a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma (MARS 2)
Amount £1,725,924 (GBP)
Funding ID 15/188/31 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 01/2017 
 
Description Meta-Modelling for Value of Information Calculations Workshop.
Amount £9,160 (GBP)
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start  
 
Description Model Based Network Meta-Analysis for Pharmacometrics and Drug-Development
Amount £327,555 (GBP)
Funding ID MR/M005615/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 12/2017
 
Description Monitoring for neovascular AMD Reactivation at Home: the MONARCH study
Amount £1,139,565 (GBP)
Funding ID HTA/15/97/02 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description Multi-centre randomised controlled trial to compare the clinical and cost-effectiveness of a 'vein bypass first' with a 'best endovascular treatment first' revascularisation strategy for severe limb ischaemia due to infra-popliteal arterial disease (BASIL
Amount £11,573 (GBP)
Funding ID HTA/12/35/45 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2016 
End 01/2017
 
Description NAP SACC UK: A feasibility cluster randomised controlled trial in child care settings to increase physical activity and healthy eating in 2-4 year olds
Amount £431,495 (GBP)
Funding ID PHR/12/153/39 
Organisation National Institute for Health Research 
Department Public Health Research (PHR) Programme
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 11/2017
 
Description NICE Clinical Guidelines Technical Support Unit
Amount £327,489 (GBP)
Organisation National Institute for Health and Care Excellence (NICE) 
Sector Public
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description NICE Clinical Guidelines Technical Support Unit.
Amount £350,000 (GBP)
Organisation National Institute for Health and Care Excellence (NICE) 
Sector Public
Country United Kingdom
Start 04/2016 
End 03/2022
 
Description NICE Clinical Guidelines Technical Support Unit.
Amount £350,000 (GBP)
Organisation National Institute for Health and Care Excellence (NICE) 
Sector Public
Country United Kingdom
Start 04/2016 
End 03/2018
 
Description NIHR HS&DR: Improving medicines use in people with polypharmacy in primary care (IMPPP)
Amount £1,872,267 (GBP)
Funding ID HS&DR/16/118/14 
Organisation National Institute for Health Research 
Department Health Services and Delivery Research (HS&DR) Programme
Sector Academic/University
Country United Kingdom
Start  
 
Description NIHR HTA
Amount £2,119,632 (GBP)
Funding ID HTA - 14/140/78 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 12/2015 
End 12/2021
 
Description NIHR HTA
Amount £655,011 (GBP)
Funding ID HTA 12/35/54 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 01/2015 
End 01/2017
 
Description NIHR HTA Programme
Amount £448,921 (GBP)
Funding ID HTA - 12/189/06 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 02/2017
 
Description NIHR HTA Programme
Amount £1,642,978 (GBP)
Funding ID HTA - 13/04/03 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2015 
End 04/2021
 
Description NIHR HTA [UK RTC Arthroscopic Surgery...]
Amount £1,727,577 (GBP)
Funding ID HTA - 13/103/02 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 04/2014 
End 02/2020
 
Description NIHR Infrastructure Short Placement Award for Research Collaboration (SPARC). Developing advanced evidence synthesis skills to inform rapid and focused surgical innovation: a training placement between the Bristol BRC (Surgical Innovation theme) and the M
Amount £2,842 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2019
 
Description NIHR PHR [Travel to Work]
Amount £972,682 (GBP)
Organisation National Institute for Health Research 
Department Public Health Research (PHR) Programme
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 03/2017
 
Description NIHR Programme Grant for Applied Research
Amount £2,233,801 (GBP)
Funding ID RP-PG-0514-20012 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2016 
End 03/2022
 
Description NIHR Research Design Service South West (RDS SW) Infrastructure grant
Amount £1,806,883 (GBP)
Organisation Infrastructure UK 
Sector Public
Country United Kingdom
Start 10/2018 
End 09/2023
 
Description NIHR Research for Patient Benefit
Amount £250,000 (GBP)
Funding ID RfPB 0214-33065 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 06/2015 
End 05/2018
 
Description NIHR RfPB - Does Laryngeal Reinnervation or Type I Thyroplasty give better voice results for patients with Unilateral Vocal Fold Paralysis (VOCALIST): a feasibility study
Amount £309,667 (GBP)
Funding ID PB-PG-1013-32058 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 07/2015 
End 08/2016
 
Description NIHR RfPB Competition 22
Amount £259,754 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2015 
End 04/2017
 
Description NIHR RfPB Competition 22 [Testing the feasibility of a consultation-level intervention for frequent attenders with clinically inexplicable symptoms in primary care. ]
Amount £249,940 (GBP)
Funding ID PB-PG-0613-31099 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 11/2014 
End 05/2017
 
Description NIHR SPCR- Identifying the Quality Indicators of a Patient-Centred Trial: obtaining expert consensus using the Delphi method
Amount £11,208 (GBP)
Organisation Scottish School of Primary Care 
Department Scottish Primary Care Research Network (SPCRN)
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 09/2015
 
Description NIHR School for Primary Care Research: Long-term condition management
Amount £79,542 (GBP)
Funding ID 207 
Organisation National Institute for Health Research 
Department School for Primary Care Research
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 06/2015
 
Description NIHR Senior Investigator Award
Amount £63,210 (GBP)
Organisation National Institute for Health Research 
Department NIHR Fellowship Programme
Sector Academic/University
Country United Kingdom
Start  
 
Description NIHR-Research for Patient Benefit [Needle fasciotomy v limited fasciectomy...]
Amount £259,754 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2015 
End 04/2017
 
Description Nasal Airway Obstruction Study (Nairos)
Amount £5,655 (GBP)
Funding ID HTA/14/226/07 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren's contractures of the fingers: a study which investigates the feasibility, acceptability and design of a multicentre randomised trial
Amount £259,754 (GBP)
Funding ID PB-PG-0613-31083 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 07/2015 
End 04/2017
 
Description OSAC (Oral Steroids for Acute Cough) Trial.
Amount £1,506,076 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2012 
End 06/2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis
Amount £3,373,808 (GBP)
Funding ID HTA - 10/34/501 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2015 
End 04/2024
 
Description Optimisation, feasibility testing and pilot randomised trial of Positive Choices: a school based social marketing intervention to promote sexual health, prevent unintended teenage pregnancies and address health inequalities in England
Amount £595,368 (GBP)
Funding ID PHR/14/184/02 
Organisation National Institute for Health Research 
Department Public Health Research (PHR) Programme
Sector Charity/Non Profit
Country United Kingdom
Start 04/2017 
End 07/2020
 
Description Optimising management of fistulating perianal Crohn's disease
Amount £56,589 (GBP)
Organisation Bowel Disease Research Foundation (BDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 05/2020
 
Description Patient-centred trials: developing measures to improve the experience of people taking part in clinical trials
Amount £7,898 (GBP)
Funding ID PB-PG-0416-20033 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 09/2017 
End 02/2019
 
Description Personal launching fellowship to disseminate work from PhD and apply for future funding
Amount £47,104 (GBP)
Organisation Avon Primary Care Research Collaborative 
Sector Public
Country United Kingdom
Start 04/2017 
End 10/2018
 
Description PhD Scholarship
Amount £13,863 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 11/2014 
End 06/2022
 
Description Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer (Compare).
Amount £170,697,200 (GBP)
Funding ID CRUK/13/026 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 11/2022
 
Description Pilot randomised trial of Project Respect: a school-based intervention to prevent dating and relationship violence and address health inequalities among young people
Amount £483,065 (GBP)
Funding ID NIHR PHR 15/03/09 
Organisation National Institute for Health Research 
Department Public Health Research (PHR) Programme
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 12/2018
 
Description Pragmatic, primary care, multi -centre, individually randomised superiority trial of four emollients in children with eczema, with internal pilot, nested economic evaluation and qualitative study
Amount £1,394,969 (GBP)
Funding ID 15/130/06 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description Primary care patients' views and experiences of treatments for depression: a secondary analysis of qualitative data
Amount £79,543 (GBP)
Funding ID 207 
Organisation National Institute for Health Research 
Department School for Primary Care Research
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 06/2015
 
Description Primary care patients' views and experiences of treatments for depression: a secondary analysis of qualitative data.
Amount £79,542 (GBP)
Funding ID 207 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 06/2015
 
Description Prioritising research for an entire clinical area (Eczema) using value of information (VoI) methods
Amount £1,789,589 (GBP)
Funding ID CDF-2014-07-006 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2014 
End 09/2017
 
Description Production of Technology Assessment Reviews (TARs) for the NIHR (Stewart)
Amount £5,249,998 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2016 
End 03/2021
 
Description ProgrammE in Costing, resource use measurement and outcome valuation for Use in multi-sectoral National and International health economic evaluAtions (PECUNIA)
Amount £65,330 (GBP)
Funding ID 779292 
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 01/2018 
End 12/2020
 
Description RCS The PreBRA Study
Amount £61,470 (GBP)
Organisation Royal College of Surgeons of England 
Sector Learned Society
Country United Kingdom
Start 10/2018 
End 10/2019
 
Description REPROVIDE (Reaching Everyone Programme of Research On Violence in diverse Domestic Environments).
Amount £2,529,230 (GBP)
Funding ID RP-PG-0614-20011 
Organisation National Institute for Health Research 
Department Programme Grants for Applied Research (PGfAR)
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 02/2022
 
Description ROMIO (Randomised Oesophagectomy: Minimally Invasive or Open): Definitive Trial.
Amount £2,119,632 (GBP)
Funding ID HTA/14/140/78 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 12/2015 
End 05/2021
 
Description Randomised Oesophagectomy: Minimally Invasive or Open: Definitive trial (ROMIO)
Amount £2,119,632 (GBP)
Funding ID HTA - 14/140/78 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 12/2015 
End 12/2021
 
Description Randomized trials of non-specific effects of childhood vaccines.
Amount £6,095 (GBP)
Organisation World Health Organization (WHO) 
Sector Public
Country Global
Start 04/2017 
End 05/2017
 
Description Refinement of and extension to the Cochrane Risk of Bias tool for Randomised trials.
Amount £50,000 (GBP)
Funding ID MR/L004933/1- N61 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 10/2016
 
Description Routinely embedding recruitment and retention interventions within randomised controlled trials
Amount £501,765 (GBP)
Funding ID MR/R013748/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 09/2020
 
Description Royal College of Surgeons of England Research Fellowship
Amount £55,000 (GBP)
Organisation Royal College of Surgeons of England 
Sector Learned Society
Country United Kingdom
Start 10/2015 
End 10/2016
 
Description SMALL: A Phase III randomised multi-centre trial addressing overtreatment of small screen-detected breast cancer by comparing standard surgery with minimally invasive vacuum-assisted excision
Amount £2,319,114 (GBP)
Funding ID HTA/17/42/32 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2018 
End 06/2029
 
Description Screening Strategies for Atrial Fibrillation: A Systematic Review and Cost-Effectiveness Analysis.
Amount £181,379 (GBP)
Funding ID HTA/14/141/01 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description Smoking in FE colleges (Fletcher)
Amount £72,400 (GBP)
Organisation National Institute for Health Research 
Department Public Health Research (PHR) Programme
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 06/2016
 
Description Starter Grants for Clinical Lecturers
Amount £26,250 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2015 
End 08/2017
 
Description State-of-the-art workshop: Methods for placebo comparator group selection and use in surgical trials
Amount £49,471 (GBP)
Funding ID MC_PC_17155 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 06/2019
 
Description Studies to inform clinical aortic aneurysm research (including the development of an aortic aneurysm patient focus group and pilot stuies in emergency surgery
Amount £176,000 (GBP)
Organisation David Telling Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2016 
End 12/2018
 
Description Testing Radical prostatectomy in men with prostate cancer and oligoMetastases to the bone: a randomised controlled feasibility trial
Amount £183,000 (GBP)
Organisation Prostate Cancer Foundation 
Sector Charity/Non Profit
Country Global
Start 10/2015 
End 10/2018
 
Description The BRaveR Study - Methods to develop and deliver Better ReseArch to improVe outcomes and inform practice in brEast Reconstruction
Amount £1,118,847 (GBP)
Funding ID CS-2016-16-019 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2017 
 
Description The Bluebelle study: a feasibility study of three wound dressing strategies in eLective and unplanned surgery
Amount £444,264 (GBP)
Funding ID HTA/12/200/04 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 06/2014 
End 06/2016
 
Description The MRC ConDuCT-II Hub. Collaboration and iNnovation in DifficUlt and Complex randomised controlled Trials In Invasive procedures
Amount £2,000,000 (GBP)
Funding ID MR/K025643/1 
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description The Pre-BRA (Pre-pectoral Breast Reconstruction Evaluation) Study. An IDEAL 2a/2b prospective cohort study to determine the safety and effectiveness of pre-pectoral implant based breast reconstruction
Amount £10,000 (GBP)
Organisation Association of Breast Surgery 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description The Prepare-Me study: a randomised controlled trial of preparation for dialysis or conservative care.
Amount £1,784,741 (GBP)
Funding ID HTA - 15/57/39 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 01/2017 
End 07/2022
 
Description The Prepare-Me study: a randomised controlled trial of preparation for dialysis or conservative care.
Amount £1,784,741 (GBP)
Funding ID HTA - 15/57/39 
Organisation NIHR Trauma Nework 
Sector Public
Country United Kingdom
Start 01/2017 
End 07/2022
 
Description The ProtecT study: Prostate testing for cancer and treatment.
Amount £2,656,176 (GBP)
Funding ID HTA/96/20/99 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 01/2014 
End 12/2016
 
Description The VIOLET trial - VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot
Amount £1,642,978 (GBP)
Funding ID HTA/13/04/03 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 08/2015 
End 10/2020
 
Description The choice between hip prosthetic bearing surfaces in total hip replacement: evidence synthesis, statistical analysis and decision modelling to evaluate the effectiveness and cost-effectiveness of prosthetic implants for the NHS.
Amount £230,304 (GBP)
Funding ID PB-PG-0613-31032 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start  
 
Description The iBRA (implant Breast Reconstruction evAluation) study - A prospective multicentre cohort study to inform the feasibility and conduct a pragmatic randomised clinical trial comparing new techniques of implant-based breast reconstruction
Amount £243,418 (GBP)
Funding ID RfPB 0214-33065 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 06/2015 
End 05/2018
 
Description The iBRA (implant Breast Reconstruction evAluation) study - A prospective multicentre cohort study to inform the feasibility and conduct a pragmatic randomised clinical trial comparing new techniques of implant-based breast reconstruction.
Amount £249,000 (GBP)
Funding ID PB-PG-0214-33065 
Organisation National Institute for Health Research 
Department Research for Patient Benefit
Sector Public
Country United Kingdom
Start 06/2015 
End 05/2018
 
Description To develop a cluster randomised controlled trial to evaluate a consultation-level intervention for frequently attending patients in primary care: The Footprints in Primary Care Study.
Amount £22,266 (GBP)
Organisation Avon Primary Care Research Collaborative 
Sector Public
Country United Kingdom
Start  
 
Description Training workshops for recruiters to randomised trials.
Amount £28,822 (GBP)
Organisation National Institute for Health Research 
Department NIHR Clinical Research Network (CRN)
Sector Public
Country United Kingdom
Start 10/2015 
End 03/2017
 
Description Treatment effectiveness in multimorbidity: Combining efficacy estimates from clinical trials with the natural history obtained from large routine healthcare databases to determine net overall treatment benefits.
Amount £40,823 (GBP)
Funding ID 201492/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2014 
End 08/2020
 
Description UK Cohort study to Investigate the prevention of Parastomal Hernia (CIPHER)
Amount £1,041,678 (GBP)
Funding ID HTA/14/166/01 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2016 
End 04/2022
 
Description UK Cohort study to Investigate the prevention of Parastomal Hernia (CIPHER)
Amount £1,410,678 (GBP)
Funding ID HTA/14/166/01 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description UNBLOCS: laser or saline/bipolar surgery
Amount £1,100,000 (GBP)
Funding ID HTA - 12/35/15 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description UNBLOCS: laser or saline/bipolar surgery.
Amount £1,100,000 (GBP)
Funding ID HTA - 12/35/15 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description UPSTREAM: Urodynamics for Prostate Surgery: randomised Evaluation of Assessment Methods: for diagnosis and management of bladder outlet obstruction of men
Amount £1,224,219 (GBP)
Funding ID HTA - 12/140/01 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description Understanding the role of the multidisciplinary team in recruitment to randomised controlled trials: an exploratory qualitative study
Amount £55,000 (GBP)
Organisation Royal College of Surgeons of England 
Sector Learned Society
Country United Kingdom
Start 10/2015 
End 10/2016
 
Description University of Bristol Alumni: Travel award to attend SCT 2018 in U.S. to give oral presentation
Amount £450 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 05/2018 
End 05/2018
 
Description Upstream (Drake)
Amount £1,108,500 (GBP)
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2017
 
Description Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM) for diagnosis and management of bladder outlet obstruction in men
Amount £1,708,002 (GBP)
Funding ID 12/140/01 
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start 10/2014 
End 03/2018
 
Description Use of Network Meta-analysis to Inform Clinical Parameters in Economic Evaluations.
Amount £1,369 (GBP)
Organisation Canadian Agency for Drugs and Technologies in Health 
Sector Public
Country Canada
Start 01/2015 
End 04/2015
 
Description User-focused research to identify the benefits of innovative digital recruitment and retention tools for more efficient conduct of randomised trials
Amount £6,270 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2018
 
Description What are the indications for prescribing antidepressants that will lead to clinical benefit? (PANDA)
Amount £1,999,968 (GBP)
Funding ID RP-PG-0610-10048 
Organisation National Institute for Health Research 
Department Programme Grants for Applied Research (PGfAR)
Sector Charity/Non Profit
Country United Kingdom
Start 05/2014 
End 05/2017
 
Description What might a Global Health Trials Methodology Research Agenda look like?
Amount £14,436 (GBP)
Funding ID N84 
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 09/2016 
End 08/2017
 
Description Workshop': Improving the evaluation of medical devices with development of a generic core outcome set: a key stakeholder workshop for industry, innovators, clinicians, trialists, journal editors and health policy makers
Amount £9,938 (GBP)
Funding ID N101 
Organisation Medical Research Council (MRC) 
Department MRC Hubs for Trial Methodology Research
Sector Public
Country United Kingdom
Start 01/2018 
End 06/2018
 
Description Workshop: Mapping current usage of Health Economic Analysis Plans (HEAPs)
Amount £9,630 (GBP)
Funding ID N65 
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 03/2015 
End 01/2016
 
Description Workshop: Meta-Modelling for Value of Information Calculations Workshop (Workshop on 19th Sept 2014 in Bristol)
Amount £9,160 (GBP)
Funding ID R54 
Organisation Medical Research Council (MRC) 
Department Network of Hubs for Trials Methodology Research (HTMR)
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 09/2014
 
Description A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with MRCP in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones: The Sunflower Study. (NIHR HTA Programme grant) 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution C Rogers, K Avery, J Blazeby, W Hollingworth, N Blencowe, and L Culliford are co-applicants on grant and K Avery PPI lead.
Collaborator Contribution Leading and conducting the study
Impact None yet
Start Year 2017
 
Description A systematic review of the ORRCA database for methods to improve recruitment for unplanned hospital admissions 
Organisation Medical Research Council (MRC)
Department Network of Hubs for Trials Methodology Research (HTMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution We will be performing a systematic review of all articles included in the ORRCA database with the aim of identifying those studies which focus on recruitment of unplanned hospital admissions to randomised controlled trials. Alongside this, our department continues to contribute to screening and categorising ORRCA articles, as part of the ongoing development of the ORRCA resource.
Collaborator Contribution The above departments conceptualised and designed the ORRCA database (http://www.orrca.org.uk). They have been responsible for the development of the protocol, search strategy/process and screening processes and all other activities required to form the database.
Impact None yet
Start Year 2016
 
Description A systematic review of the ORRCA database for methods to improve recruitment for unplanned hospital admissions 
Organisation Queen's University Belfast
Department School of Medicine, Dentistry and Biomedical Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution We will be performing a systematic review of all articles included in the ORRCA database with the aim of identifying those studies which focus on recruitment of unplanned hospital admissions to randomised controlled trials. Alongside this, our department continues to contribute to screening and categorising ORRCA articles, as part of the ongoing development of the ORRCA resource.
Collaborator Contribution The above departments conceptualised and designed the ORRCA database (http://www.orrca.org.uk). They have been responsible for the development of the protocol, search strategy/process and screening processes and all other activities required to form the database.
Impact None yet
Start Year 2016
 
Description A systematic review of the ORRCA database for methods to improve recruitment for unplanned hospital admissions 
Organisation University of Aberdeen
Department Health Services Research Unit
Country United Kingdom 
Sector Public 
PI Contribution We will be performing a systematic review of all articles included in the ORRCA database with the aim of identifying those studies which focus on recruitment of unplanned hospital admissions to randomised controlled trials. Alongside this, our department continues to contribute to screening and categorising ORRCA articles, as part of the ongoing development of the ORRCA resource.
Collaborator Contribution The above departments conceptualised and designed the ORRCA database (http://www.orrca.org.uk). They have been responsible for the development of the protocol, search strategy/process and screening processes and all other activities required to form the database.
Impact None yet
Start Year 2016
 
Description A systematic review of the ORRCA database for methods to improve recruitment for unplanned hospital admissions 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution We will be performing a systematic review of all articles included in the ORRCA database with the aim of identifying those studies which focus on recruitment of unplanned hospital admissions to randomised controlled trials. Alongside this, our department continues to contribute to screening and categorising ORRCA articles, as part of the ongoing development of the ORRCA resource.
Collaborator Contribution The above departments conceptualised and designed the ORRCA database (http://www.orrca.org.uk). They have been responsible for the development of the protocol, search strategy/process and screening processes and all other activities required to form the database.
Impact None yet
Start Year 2016
 
Description A systematic review of the ORRCA database for methods to improve recruitment for unplanned hospital admissions 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution We will be performing a systematic review of all articles included in the ORRCA database with the aim of identifying those studies which focus on recruitment of unplanned hospital admissions to randomised controlled trials. Alongside this, our department continues to contribute to screening and categorising ORRCA articles, as part of the ongoing development of the ORRCA resource.
Collaborator Contribution The above departments conceptualised and designed the ORRCA database (http://www.orrca.org.uk). They have been responsible for the development of the protocol, search strategy/process and screening processes and all other activities required to form the database.
Impact None yet
Start Year 2016
 
Description Advisor to NIHR fellowship application 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Advice during application development and will sit on advisory board if funded.
Collaborator Contribution Advice during application development and will sit on advisory board if funded.
Impact multi-disciplinary - Biostats
Start Year 2016
 
Description Advisory for trial conduct (PACE study) 
Organisation Institute of Cancer Research UK
Department Cancer Research UK Cancer Therapeutics Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Advice on trial conduct.
Collaborator Contribution leading and conducting the study.
Impact multi-disciplinary - Surgery/radiotherapy/Prostate Cancer specialists
Start Year 2016
 
Description Application of PIC to evaluate informed consent consultations within the OPTIMISE Trial 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Julia Wade to advise on application of the PIC measure of informed consent
Collaborator Contribution Provision of informed consent consultation data from the OPTIMISE trial to enable further development of PIC tool.
Impact Not known
Start Year 2018
 
Description Ashma Krishan PhD 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution My input: supervision
Collaborator Contribution N/A
Impact No outputs or impacts yet
Start Year 2015
 
Description Becky Boucher fellowship 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide advice on statistical methodology
Collaborator Contribution Fellowship programme of work, publications
Impact None yet, just startaed
Start Year 2014
 
Description CEDAR Peers Supporting Physical Activity 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Economic analysis
Collaborator Contribution Economic analysis
Impact N/A
Start Year 2015
 
Description COMET Choice of moisturizer in eczema treatment. Alane investigator on study. 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Intellectual input
Collaborator Contribution Intellectual input and conducting of research
Impact None as yet
Start Year 2013
 
Description COMET initiative 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributed to a grant proposal to implement research guidelines
Collaborator Contribution Developed and submitted the grant proposal
Impact Grant was rejected
Start Year 2015
 
Description CONservative TReatment of Appendicitis in Children - a randomised controlled Trial - CONTRACT (Feasibility study 
Organisation Alder Hey Children's NHS Foundation Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Esther Crawley is a co-applicant. Lucy Beasant will be conducting interviews. Both Lucy and Esther Crawley helped write the application focusing on the preference elements.
Collaborator Contribution Nigel Hall. National Institute for Health Research (NIHR) Health Technology Assessment
Impact None yet
Start Year 2016
 
Description CONservative TReatment of Appendicitis in Children - a randomised controlled Trial - CONTRACT (Feasibility study 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution Esther Crawley is a co-applicant. Lucy Beasant will be conducting interviews. Both Lucy and Esther Crawley helped write the application focusing on the preference elements.
Collaborator Contribution Nigel Hall. National Institute for Health Research (NIHR) Health Technology Assessment
Impact None yet
Start Year 2016
 
Description CONservative TReatment of Appendicitis in Children - a randomised controlled Trial - CONTRACT (Feasibility study 
Organisation St George's University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Esther Crawley is a co-applicant. Lucy Beasant will be conducting interviews. Both Lucy and Esther Crawley helped write the application focusing on the preference elements.
Collaborator Contribution Nigel Hall. National Institute for Health Research (NIHR) Health Technology Assessment
Impact None yet
Start Year 2016
 
Description CONservative TReatment of Appendicitis in Children - a randomised controlled Trial - CONTRACT (Feasibility study 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Esther Crawley is a co-applicant. Lucy Beasant will be conducting interviews. Both Lucy and Esther Crawley helped write the application focusing on the preference elements.
Collaborator Contribution Nigel Hall. National Institute for Health Research (NIHR) Health Technology Assessment
Impact None yet
Start Year 2016
 
Description CONservative TReatment of Appendicitis in Children - a randomised controlled Trial - CONTRACT (Feasibility study 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Esther Crawley is a co-applicant. Lucy Beasant will be conducting interviews. Both Lucy and Esther Crawley helped write the application focusing on the preference elements.
Collaborator Contribution Nigel Hall. National Institute for Health Research (NIHR) Health Technology Assessment
Impact None yet
Start Year 2016
 
Description COPD bundles study (NIHR) 
Organisation North Bristol NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Statistical and clinical trials methodology expertise
Collaborator Contribution Strategy and organisation behaviour, emergency and critical care research, clinical expertise
Impact http://www.ncbi.nlm.nih.gov/pubmed/26916196
Start Year 2014
 
Description COPD bundles study (NIHR) 
Organisation Sue Jenkins & Associates
Country United Kingdom 
Sector Private 
PI Contribution Statistical and clinical trials methodology expertise
Collaborator Contribution Strategy and organisation behaviour, emergency and critical care research, clinical expertise
Impact http://www.ncbi.nlm.nih.gov/pubmed/26916196
Start Year 2014
 
Description COPD bundles study (NIHR) 
Organisation University of the West of England
Country United Kingdom 
Sector Academic/University 
PI Contribution Statistical and clinical trials methodology expertise
Collaborator Contribution Strategy and organisation behaviour, emergency and critical care research, clinical expertise
Impact http://www.ncbi.nlm.nih.gov/pubmed/26916196
Start Year 2014
 
Description COS-STAR 
Organisation University of Liverpool
Department Institute of Translational Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Completion of 2 surveys and participation in a 1 day consensus meeting. This will lead to guidelines publication
Collaborator Contribution Organisation of the work
Impact None yet
Start Year 2016
 
Description Collaboration: Methodological challenges in healthcare resource-use measurement: towards good practice 
Organisation Maastricht University (UM)
Country Netherlands 
Sector Academic/University 
PI Contribution Organised session at 10th iHEA/ECHE Congress, Dublin (July 2014)
Collaborator Contribution Organised session at 10th iHEA/ECHE Congress, Dublin (July 2014)
Impact .
Start Year 2014
 
Description Collaborator: MRC-MRP bid to develop a SPIRIT-PRO Extension, web based training tool and guidance for ethics committees 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a short-listed bid - funding not yet confirmed.
Collaborator Contribution Contributions has been commenting on bid.
Impact Outcomes still in progress.
Start Year 2014
 
Description Collaborator: MRC-MRP bid to develop a SPIRIT-PRO Extension, web based training tool and guidance for ethics committees 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a short-listed bid - funding not yet confirmed. Contributions has been commenting on bid
Collaborator Contribution Development of bid
Impact none yet
Start Year 2014
 
Description Consideration of an independent evaluation of the QRI as a SWA 
Organisation University of York
Department York Trials Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Nicola Mills is leading the Bristol input
Collaborator Contribution Connections made between Bristol and York Unis to evaluate ConduCT-II/QuinteT recruitment workshops as a SWAT
Impact Unknown
Start Year 2018
 
Description Developing guidelines for use of trial registry data in systematic reviews 
Organisation University of Saskatchewan
Country Canada 
Sector Academic/University 
PI Contribution Jelena Savovic was senior methodological advisor.
Collaborator Contribution Julia Bidonde and Jose Menezes-Echavez (Norwegian Institute) and Catherine Boden (Saskatchewan) all performed the data collection for a systematic review.
Impact Not known
Start Year 2017
 
Description Development and feasibility cluster randomised controlled trial of a Peer-Led physical Activity iNtervention for Adolescent girls (Plan-A) 
Organisation Swansea University
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research expertise
Impact None yet
Start Year 2015
 
Description Development of online training kit for RCT recruiters 
Organisation NIHR London (South) CRN
Country United Kingdom 
Sector Public 
PI Contribution Developing the online training using data and advice from Bristol
Collaborator Contribution Mills and Rooshenas are co-leading the Bristol input
Impact Online training tool for RCT recruitment
Start Year 2018
 
Description Discussions to offer recruitment training to Swedish bariatrics 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution Mills is leading the Bristol input
Collaborator Contribution Connection made with Bristol team to discuss training recruiters to the BEST RCT
Impact Unknown
Start Year 2018
 
Description EVSI for adaptive designs 
Organisation Newcastle University
Department Academic Psychiatry and Regional Affective Disorders Service
Country United Kingdom 
Sector Academic/University 
PI Contribution Joined the HTMR working group on adaptive designs. Preparing grant to submit grant (NIRG) proposal to MRC
Collaborator Contribution Leads work.
Impact Unknown
Start Year 2018
 
Description EVSI for adaptive designs 
Organisation University of Cambridge
Department Cambridge University Health Partners
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Joined the HTMR working group on adaptive designs. Preparing grant to submit grant (NIRG) proposal to MRC
Collaborator Contribution Leads work.
Impact Unknown
Start Year 2018
 
Description EVSI for adaptive designs 
Organisation University of Oxford
Department Wolfson College
Country United Kingdom 
Sector Academic/University 
PI Contribution Joined the HTMR working group on adaptive designs. Preparing grant to submit grant (NIRG) proposal to MRC
Collaborator Contribution Leads work.
Impact Unknown
Start Year 2018
 
Description EVSI for adaptive designs 
Organisation University of Pittsburgh
Country United States 
Sector Academic/University 
PI Contribution Joined the HTMR working group on adaptive designs. Preparing grant to submit grant (NIRG) proposal to MRC
Collaborator Contribution Leads work.
Impact Unknown
Start Year 2018
 
Description EVSI for adaptive designs 
Organisation University of Sheffield
Department University of Sheffield, Tissue resource
Country United Kingdom 
Sector Academic/University 
PI Contribution Joined the HTMR working group on adaptive designs. Preparing grant to submit grant (NIRG) proposal to MRC
Collaborator Contribution Leads work.
Impact Unknown
Start Year 2018
 
Description Examining the influence of an informational video on participant retention in a randomised controlled trial. 
Organisation National University of Ireland, Galway
Country Ireland 
Sector Academic/University 
PI Contribution Clare Clement will advise on SWAT design, implementation and analysis
Collaborator Contribution Leading and conducting the study.
Impact Not known
Start Year 2017
 
Description Extending ORRCA to create a central resource for retention research within clinical trials (ORRCA 2) 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Athene Lane will provide expertise in trial recruitment and retention
Collaborator Contribution Expertise in clinical trials methodology
Impact None yet
Start Year 2018
 
Description FOOTPRINTS in primary care study (NIHR RfPB) 
Organisation Frome Valley Health Ltd
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Statistical and clinical trials methodology expertise
Collaborator Contribution Clinical expertise
Impact None yet
Start Year 2014
 
Description Fellowship (DM) 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Statistical expertise
Collaborator Contribution Leads work
Impact Not known
Start Year 2015
 
Description Fellowship (SD) 
Organisation Medical Research Council (MRC)
Department MRC North West Hub for Trials Methodology Research
Country United Kingdom 
Sector Public 
PI Contribution Advising on work and providing statistical expertise
Collaborator Contribution Leading the work and doing the analyses
Impact Not known
Start Year 2016
 
Description Fellowship (TS) 
Organisation University of East Anglia
Country United Kingdom 
Sector Academic/University 
PI Contribution Attendance at annual advisory group meeting and regular mentoring teleconferences
Collaborator Contribution Leads work
Impact Not known
Start Year 2015
 
Description General Practioners and Emergency Departments (GPED): Efficient models of care 
Organisation NHS Bristol CCG
Country United Kingdom 
Sector Public 
PI Contribution Co-Investigator
Collaborator Contribution CCG hosts the trial, UWE leads the trial, York does economics and statistics and Newcastle leads qualitative research.
Impact Not known
Start Year 2017
 
Description General Practioners and Emergency Departments (GPED): Efficient models of care 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-Investigator
Collaborator Contribution CCG hosts the trial, UWE leads the trial, York does economics and statistics and Newcastle leads qualitative research.
Impact Not known
Start Year 2017
 
Description General Practioners and Emergency Departments (GPED): Efficient models of care 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-Investigator
Collaborator Contribution CCG hosts the trial, UWE leads the trial, York does economics and statistics and Newcastle leads qualitative research.
Impact Not known
Start Year 2017
 
Description General Practioners and Emergency Departments (GPED): Efficient models of care 
Organisation University of the West of England
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-Investigator
Collaborator Contribution CCG hosts the trial, UWE leads the trial, York does economics and statistics and Newcastle leads qualitative research.
Impact Not known
Start Year 2017
 
Description HEAPS Workshop 
Organisation University of Oxford
Department Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU)
Country United Kingdom 
Sector Academic/University 
PI Contribution Economic analysis
Collaborator Contribution Economic analysis
Impact No outputs yet
Start Year 2015
 
Description HTMR Recruitment to Trials Working Group membership 
Organisation Medical Research Council (MRC)
Department Network of Hubs for Trials Methodology Research (HTMR)
Country United Kingdom 
Sector Academic/University 
PI Contribution collaborative work to identify priority areas to improve trial recruitment - involvement includes contribution to discussions, research dissemination and workshop design and delivery
Collaborator Contribution collaborative work to identify priority areas to improve trial recruitment - involvement includes contribution to discussions, research dissemination and workshop design and delivery (as above as this is collaborative work). Funding for workshops.
Impact Outcomes: Two workshops funded and run; "Developing, delivering and evaluating training courses for recruiters to randomised trials" and two-day workshop on "the design and analysis of clinical trials in head and neck cancer". Educational impact. Multidisciplinary: health services research, clinical, academic, quantitative research, qualitative research
Start Year 2011
 
Description Health Informatics: Use of the electronic health record in the design and conduct of clinical trials. (MRC HTMR) 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Statistical expertise
Impact Not known
Start Year 2014
 
Description IDEAL-D collaboration 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution International consensus process to develop research guidelines
Collaborator Contribution International consensus process to develop research guidelines
Impact No impacts yet
Start Year 2014
 
Description ISRUM (Items for a standardised resource-use measure) 
Organisation University of Oxford
Department Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU)
Country United Kingdom 
Sector Academic/University 
PI Contribution Economic analysis
Collaborator Contribution Economic analysis
Impact No outputs yet
Start Year 2015
 
Description Identifying and critiquing different approaches to developing complex interventions (INDEX study) 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of new and original thinking on research methods relating to intervention development and writing a grant application
Collaborator Contribution Partners contributed to discussions, literature reviewing and grant application writing
Impact None yet
Start Year 2016
 
Description Identifying and critiquing different approaches to developing complex interventions (INDEX study) 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of new and original thinking on research methods relating to intervention development and writing a grant application
Collaborator Contribution Partners contributed to discussions, literature reviewing and grant application writing
Impact None yet
Start Year 2016
 
Description Identifying and critiquing different approaches to developing complex interventions (INDEX study) 
Organisation University of Stirling
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of new and original thinking on research methods relating to intervention development and writing a grant application
Collaborator Contribution Partners contributed to discussions, literature reviewing and grant application writing
Impact None yet
Start Year 2016
 
Description Identifying the Quality Indicators of a Patient-Centred Trial: obtaining expert consensus using the Delphi method 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research expertise
Impact Not known
Start Year 2015
 
Description Improving the management of patients with multimorbidity in general practice 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research expertise
Impact Not known
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation Cardiff and Vale University Health Board
Country United Kingdom 
Sector Public 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation North Bristol NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation Royal Devon and Exeter NHS Foundation Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation Sheffield Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Inform: Infection after total joint replacement. (NIHR PGfAR) 
Organisation Wrightington, Wigan and Leigh NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact One-stage or two-stage revision surgery for prosthetic hip joint infection - the INFORM trial: a study protocol for a randomised controlled trial Simon Strange, Michael R. Whitehouse, Andrew D. Beswick, Tim Board, Amanda Burston, Ben Burston, Fran E. Carroll, Paul Dieppe, Kirsty Garfield, Rachael Gooberman-Hill, Stephen Jones, Setor Kunutsor, Athene Lane, Erik Lenguerrand, Alasdair MacGowan, Andrew Moore, Sian Noble, Joanne Simon, Ian Stockley, Adrian H. Taylor, Andrew Toms, Jason Webb, John-Paul Whittaker, Matthew Wilson, Vikki Wylde, and Ashley W. Blom
Start Year 2014
 
Description Investigating the effectiveness and cost effectiveness of using FITNET to treat paediatric CFS/ME in the UK 
Organisation Radboud University Nijmegen
Country Netherlands 
Sector Academic/University 
PI Contribution Nicola Mills will oversee the qualitative research to understand and address recruitment difficulties. Bristol will lead the main study. Disciplines include clinical, health economics, social science, health care evaluation.
Collaborator Contribution Research expertise
Impact None yet
Start Year 2015
 
Description Investigating the effectiveness and cost effectiveness of using FITNET to treat paediatric CFS/ME in the UK 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution Nicola Mills will oversee the qualitative research to understand and address recruitment difficulties. Bristol will lead the main study. Disciplines include clinical, health economics, social science, health care evaluation.
Collaborator Contribution Research expertise
Impact None yet
Start Year 2015
 
Description Joint Trial Steering Committee project 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Athene Lane collaborating with UCL partners to develop recommendations for conduct of TSCs and deliver a workshop with the NIHR HTA.
Collaborator Contribution Carol Gamble Liverpool and Matt Sydes UCL as Athene Lane.
Impact multi-disciplinary
Start Year 2016
 
Description Laura Flight fellowship 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution My input: expert advisory panel member
Collaborator Contribution N/A
Impact No outputs or impacts yet
Start Year 2015
 
Description Losing the losses: understanding the reasons for attrition in RCTs and developing the evidence to prevent it. (MRC MRP) 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Statistical expertise
Impact Not known
Start Year 2014
 
Description MRC HTMR: Trial Forge: A Lane 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Intellectual input
Collaborator Contribution Intellectual input and networking with other methodologists to raise awareness of initiative.
Impact None as yet
Start Year 2014
 
Description MRC Trials Methodology Research Partnership 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-lead
Collaborator Contribution Co-leads
Impact Multidisciplinary. Trialists, social scientist, methodologist
Start Year 2019
 
Description MRC Trials Methodology Research Partnership 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-lead
Collaborator Contribution Co-leads
Impact Multidisciplinary. Trialists, social scientist, methodologist
Start Year 2019
 
Description MRC Trials Methodology Research Partnership 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-lead
Collaborator Contribution Co-leads
Impact Multidisciplinary. Trialists, social scientist, methodologist
Start Year 2019
 
Description Methodology and development of Core Outcome Sets / Core Information Sets 
Organisation European Commission
Department Seventh Framework Programme (FP7)
Country European Union (EU) 
Sector Public 
PI Contribution Contributed to workshop facilitation, presentation at COMET PPI workshop, teleconferences discussion about optimal methodology
Collaborator Contribution Guidance on methodology, generated and facilitated workshops, sharing of expertise
Impact Presentation at COMET PPI workshop Presentation and help with facilitation of COMET methodological workshop Multi-disciplinary: statisticians, trial methodologists, health professionals
Start Year 2012
 
Description Model Based Network Meta-Analysis 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution Successful MRC grant, that is just about to begin. Pfizer bring model based meta-analysis expertise, and Bristol bring network meta-analysis skills. Funds come jointly from MRC MICA Methodology Research grant and from pfizer.
Collaborator Contribution Pfizer bring model based meta-analysis expertise and access to datasets and relevant examples.
Impact MRC MICA grant
Start Year 2014
 
Description Model based network meta-analysis 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution Leading the research project
Collaborator Contribution Statistical expertise, applied datasets, industry perspective. Part-fund a researcher
Impact Not known
Start Year 2014
 
Description NAP SACC Feasibility Trial 
Organisation North Somerset Council
Country United Kingdom 
Sector Public 
PI Contribution Economic analysis
Collaborator Contribution Economic analysis
Impact N/A
Start Year 2014
 
Description Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren's 
Organisation Wiltshire County Council
Country United Kingdom 
Sector Public 
PI Contribution Economic analysis
Collaborator Contribution Economic analysis
Impact No outputs yet
Start Year 2015
 
Description Netherlands collaboration with ZonMw (HTA equivalent) to explore routine use of QRI methods for monitoring processes in clinical trials. 
Organisation ZonMw
PI Contribution Jenny Donovan is leading the QRI input
Collaborator Contribution Connections made between Bristol and ZonMw
Impact Not known
Start Year 2018
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation Cambridge University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation Mount Vernon Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation Ontario Institute for Cancer Research (OICR)
Country Canada 
Sector Public 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation University Hospitals Birmingham NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation University of Alberta
Country Canada 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description Optimal Personalised Treatment of early breast cancer usIng Multi-parameter Analysis 
Organisation University of Warwick
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research and clinical expertise
Impact Not known
Start Year 2015
 
Description PIRRIST study team Systematic review team 
Organisation Hub at the MRC/CRUK/BHF Clinical Trial Service Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution We are members of the PIRRIST research team and/or the systematic review team, both of which I am leading
Collaborator Contribution They are members of the research team and thus are involved in decision making and helping to support the project
Impact Abstracts accepted for ICTMC 2015 conference (oral & poster), IDEAL 2016 conference (poster) and SCT 2016 conference (oral & poster). Disciplines involved: Clinical trials methodology, ethics, social science, surgery
Start Year 2015
 
Description PIRRIST study team Systematic review team 
Organisation Medical Research Council (MRC)
Department MRC North West Hub for Trials Methodology Research
Country United Kingdom 
Sector Public 
PI Contribution We are members of the PIRRIST research team and/or the systematic review team, both of which I am leading
Collaborator Contribution They are members of the research team and thus are involved in decision making and helping to support the project
Impact Abstracts accepted for ICTMC 2015 conference (oral & poster), IDEAL 2016 conference (poster) and SCT 2016 conference (oral & poster). Disciplines involved: Clinical trials methodology, ethics, social science, surgery
Start Year 2015
 
Description PIRRIST study team Systematic review team 
Organisation University of Aberdeen
Department Health Services Research Unit
Country United Kingdom 
Sector Public 
PI Contribution We are members of the PIRRIST research team and/or the systematic review team, both of which I am leading
Collaborator Contribution They are members of the research team and thus are involved in decision making and helping to support the project
Impact Abstracts accepted for ICTMC 2015 conference (oral & poster), IDEAL 2016 conference (poster) and SCT 2016 conference (oral & poster). Disciplines involved: Clinical trials methodology, ethics, social science, surgery
Start Year 2015
 
Description PIRRIST study team Systematic review team 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution We are members of the PIRRIST research team and/or the systematic review team, both of which I am leading
Collaborator Contribution They are members of the research team and thus are involved in decision making and helping to support the project
Impact Abstracts accepted for ICTMC 2015 conference (oral & poster), IDEAL 2016 conference (poster) and SCT 2016 conference (oral & poster). Disciplines involved: Clinical trials methodology, ethics, social science, surgery
Start Year 2015
 
Description PIRRIST study team Systematic review team 
Organisation University of the West of England
Country United Kingdom 
Sector Academic/University 
PI Contribution We are members of the PIRRIST research team and/or the systematic review team, both of which I am leading
Collaborator Contribution They are members of the research team and thus are involved in decision making and helping to support the project
Impact Abstracts accepted for ICTMC 2015 conference (oral & poster), IDEAL 2016 conference (poster) and SCT 2016 conference (oral & poster). Disciplines involved: Clinical trials methodology, ethics, social science, surgery
Start Year 2015
 
Description PPI and Qualitative Research guidance for trials 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of new and original thinking on research methods relating to PPI and qualitative research and writing a paper.
Collaborator Contribution Partners contributed to discussion, literature reviewing and article writing.
Impact None yet
Start Year 2015
 
Description PPI and Qualitative Research guidance for trials 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of new and original thinking on research methods relating to PPI and qualitative research and writing a paper.
Collaborator Contribution Partners contributed to discussion, literature reviewing and article writing.
Impact None yet
Start Year 2015
 
Description PPI and Qualitative Research guidance for trials 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of new and original thinking on research methods relating to PPI and qualitative research and writing a paper.
Collaborator Contribution Partners contributed to discussion, literature reviewing and article writing.
Impact None yet
Start Year 2015
 
Description PPI and Qualitative Research guidance for trials 
Organisation University of Stirling
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution of new and original thinking on research methods relating to PPI and qualitative research and writing a paper.
Collaborator Contribution Partners contributed to discussion, literature reviewing and article writing.
Impact None yet
Start Year 2015
 
Description PhD (AK) 
Organisation Medical Research Council (MRC)
Department MRC North West Hub for Trials Methodology Research
Country United Kingdom 
Sector Public 
PI Contribution Co-supervisor
Collaborator Contribution Main supervisor
Impact Not known
Start Year 2015
 
Description PhD (LF) 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution On advisory committee for PhD
Collaborator Contribution Leads work
Impact Not known
Start Year 2016
 
Description PhD (RB) 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution On advisory committee for PhD
Collaborator Contribution Leads work
Impact Not known
Start Year 2015
 
Description Qualitative research advisers to CONSORT Pilot and Feasibility Study Reporting Guideline Group 
Organisation McMaster University
Country Canada 
Sector Academic/University 
PI Contribution Hoddinott and O'Cathain attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies.
Collaborator Contribution Attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies - collaboratively with our team members.
Impact Paper planned. Multidisciplinary: collaboration between health service statisticians and methodologists.
Start Year 2014
 
Description Qualitative research advisers to CONSORT Pilot and Feasibility Study Reporting Guideline Group 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Hoddinott and O'Cathain attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies.
Collaborator Contribution Attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies - collaboratively with our team members.
Impact Paper planned. Multidisciplinary: collaboration between health service statisticians and methodologists.
Start Year 2014
 
Description Qualitative research advisers to CONSORT Pilot and Feasibility Study Reporting Guideline Group 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Hoddinott and O'Cathain attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies.
Collaborator Contribution Attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies - collaboratively with our team members.
Impact Paper planned. Multidisciplinary: collaboration between health service statisticians and methodologists.
Start Year 2014
 
Description Qualitative research advisers to CONSORT Pilot and Feasibility Study Reporting Guideline Group 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Hoddinott and O'Cathain attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies.
Collaborator Contribution Attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies - collaboratively with our team members.
Impact Paper planned. Multidisciplinary: collaboration between health service statisticians and methodologists.
Start Year 2014
 
Description Qualitative research advisers to CONSORT Pilot and Feasibility Study Reporting Guideline Group 
Organisation University of Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Hoddinott and O'Cathain attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies.
Collaborator Contribution Attended a meeting in February 2014 (invitation only) and a 2 day international meeting in October 2014; these meetings enabled members to reach a consensus on guidelines for reporting qualitative research in feasibility and pilot studies - collaboratively with our team members.
Impact Paper planned. Multidisciplinary: collaboration between health service statisticians and methodologists.
Start Year 2014
 
Description R for cost-effectiveness analysis 
Organisation Bangor University
Department School of Healthcare Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Organised a HTMR funded workshop (July 11th 2018) at University College London with over 50 attendees. Organised workshop at ISPOR EU 2018 conference. Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Collaborator Contribution Leads works.
Impact Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Start Year 2018
 
Description R for cost-effectiveness analysis 
Organisation University College London
Department CoMPLEX, University College London, UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Organised a HTMR funded workshop (July 11th 2018) at University College London with over 50 attendees. Organised workshop at ISPOR EU 2018 conference. Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Collaborator Contribution Leads works.
Impact Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Start Year 2018
 
Description R for cost-effectiveness analysis 
Organisation University of Oxford
Department Phonetics Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution Organised a HTMR funded workshop (July 11th 2018) at University College London with over 50 attendees. Organised workshop at ISPOR EU 2018 conference. Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Collaborator Contribution Leads works.
Impact Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Start Year 2018
 
Description R for cost-effectiveness analysis 
Organisation University of York
Department York Trials Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Organised a HTMR funded workshop (July 11th 2018) at University College London with over 50 attendees. Organised workshop at ISPOR EU 2018 conference. Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Collaborator Contribution Leads works.
Impact Had R for CEA pilot course accepted by University of Bristol (start March 2019).
Start Year 2018
 
Description STAR (NIHR) 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Clinical Trials methodology expertise
Collaborator Contribution Clinical expertise
Impact None yet
Start Year 2016
 
Description Steering Group and advice 
Organisation University of Bristol
Department Centre for Academic Primary Care
Country United Kingdom 
Sector Academic/University 
PI Contribution Athene Lane sits on steering group and Clare Clement provides methodological advice.
Collaborator Contribution leading and conducting the study.
Impact multi-disciplinary - trial methodologists, primary care practitioners and academics
Start Year 2016
 
Description Steering Group member for Qualiative Research in Trials Centre (QUESTS) 
Organisation National University of Ireland
Country Ireland 
Sector Academic/University 
PI Contribution Advised on qualitative research in trials, conducted webinar
Collaborator Contribution Advised on qualitative research in trials, discussion of appropriate network, engagement and dissemination activities
Impact Not known
Start Year 2016
 
Description Steering Group member for Qualiative Research in Trials Centre (QUESTS) 
Organisation National University of Ireland
Country Ireland 
Sector Academic/University 
PI Contribution Advised on qualitative research in trials, conducted webinar
Collaborator Contribution Advised on qualitative research in trials, discussion of appropriate network, engagement and dissemination activities
Impact Collaboration is multi-disciplinary and the disciplines involved are Academic disciplines (Trials methodology, Statistics, health psychology, social science) and medical disciplines (nursing and midwifery)
Start Year 2016
 
Description TOGA Trial Steering Committee independent membership 
Organisation BUPA
Department BUPA Foundation
Country United Kingdom 
Sector Private 
PI Contribution Independent member of the Trial Steering Committee (with a role relating to qualitative methods within trials) for the TOGA trial
Collaborator Contribution Cardiff University is the sponsor and Bupa Foundation is the funder.
Impact Not yet known Multidisciplinary
Start Year 2012
 
Description TOGA Trial Steering Committee independent membership 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Independent member of the Trial Steering Committee (with a role relating to qualitative methods within trials) for the TOGA trial
Collaborator Contribution Cardiff University is the sponsor and Bupa Foundation is the funder.
Impact Not yet known Multidisciplinary
Start Year 2012
 
Description TeaM Study 
Organisation Nottingham City Hospital
Department Nottingham Breast Institute
PI Contribution Leading new collaborative project
Collaborator Contribution Contributing to collaborative project 2016
Impact None yet
Start Year 2016
 
Description The Bluebelle Study: feasiBiLity stUdy of complEx, simple & aBsEnt wound dressings in eLective surgery. 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Research expertise
Collaborator Contribution Research expertise
Impact Not known
Start Year 2014
 
Description The Rosetrees and the RCS Clinical Trials Initiative: Surgical Specialty Lead in UGI Surgery for Trials, J Blazeby 
Organisation Royal College of Surgeons of England
Country United Kingdom 
Sector Learned Society 
PI Contribution Surgical Specialty Lead in Upper GI Surgery for Trials, which involves developing new trials, establishing networks, and working with patients to deliver innovative trials.
Collaborator Contribution Remit is the same for the other surgical leads and networks in the group which covers: orthopaedics, otolaryngology, transplantation, neurosurgery, cardiothoracic surgery, head and neck, coloproctology, endocrine surgery, surgery and plastics and hand surgery.
Impact Not known.
Start Year 2012
 
Description The STAR programme