A hub for Engineering and exploiting the stem cell niche

Lead Research Organisation: University of Edinburgh
Department Name: MRC Centre for Regenerative Medicine

Abstract

Stem cells have great potential in medicine as they can grow into many different cell types in the body. Our aim is to create a hub of scientists and clinicians working to understand what controls the behaviour of stem cells in their normal tissue environment.

The niche ("the soil") that surrounds stem/progenitor cells ("the seed") in developing or damaged organs has a profound effect upon the behaviour of stem/progenitor cells. The niche has received less attention than the stem cells themselves in research programs around the world. This program of work aims to fill that gap and focus work on this area. By understand how the niche influences stem cells in tissues we aim to use this knowledge to develop future treatments for serious untreatable diseases. We will do this by extending the knowledge of the niche in three main programs of work.

(1) We will extend our understanding of niches by creating artificial niches and looking at how they influence stem cells growing in them. By manipulating signals and attachments between the niches and the stem cells we can develop a clear understanding of how the niches "talk" to stem cells. When we understand clearly the signals between the niches and the stem cells we can try to influence the stem cells in the artificial niches by adding drugs or other synthetic molecules onto the stem cells to influence their behaviour.

(2) To promote "healthy regeneration" in tissues and organs we will use the information from aim 1 to test whether we can improve the growth of stem cells in the organs and tissues of experimental models of organ injury and regeneration using drugs and small synthetic molecules that will act on the stem cells and their niches.

(3) One way of treating damaged tissues and organs is to transplant stem cells or cells from stem cells into the damaged organ (such as bone marrow transplantation). Whilst this is successful in some situations, in many cases this treatment doesn't work as the cells don't grow well in the tissues. We need too understand why the tissue ("soil") does not allow the cells ("seeds") to grow well. By using information from part 1 and 2 we will seek to add the factors that we have found to keep cells "happy" and allow them to grow well in the damaged tissue.

By creating a network of scientist and doctors with different but complementary skills we aim to make these advances as quickly as possible.

Technical Summary

Our objectives and overall strategy is: (1) Through an understanding of normal tissue stem cell niches we will reconstruct the normal niche microenvironment to enable expansion and accurate differentiation of stem cells, and optimize small molecule and drug development strategies using adult stem cell, MSC, ES or iPS cell-based screening platforms. (2) To promote "healthy regeneration" we will identify the niche signals that control proliferation and differentiation of endogenous stem/progenitor cells within a diseased organ so as to facilitate the direct targeting of these cells using biological agents, drugs/small molecules or synthetic materials. This will utilise in vivo models or organ regeneration using zebrafish and then mouse models of organ injury and regeneration (3) To improve repair by transplanted cells we will understand and manipulate the abnormal niche created by the inflammation and damage of disease, as the milieu surrounding the transplanted cell has a profound effect upon both its longevity and function. We will utilise information from section (1) to facilitate this aim by providing the optimal defined niche around transplanted cells to make this successful.

Planned Impact

1. Regenerating damaged tissues and restoring their function is one of the major goals of biomedicine. Diseases that cause tissue degeneration and injury present a huge and ever-increasing clinical burden, in the UK costing the NHS well over £1 bn/year, with musculoskeletal disease alone accounting for 8.8 million UK working days lost/annum. The 'niche' hub will expedite stem/progenitor cell discoveries, focusing on developing new skeletal, liver and brain repair/regeneration strategies for patient benefit. We will achieve this by determining how local tissue niche composition, notably extracellular matrix, cytokines and growth factors, direct stem/progenitor cell phenotype, growth and differentiation, by building niche-based biomaterial platforms for tissue-specific engraftment and regulation of cell phenotype in vitro and in vivo, and by the discovery of novel targets for promoting endogenous repair. We will utilise high throughput, high content and phenotype screens (including small molecules) to fast track achievement of these key goals. Our distinctive research has the potential to transform regenerative medicine worldwide because it draws on internationally recognised strengths into how extracellular signals in the niche direct cell behaviour and phenotype and their ability to repair tissues, allowing us to address directly the well-recognised need to understand and exploit the cellular microenvironment to drive effective tissue regeneration. To engagement with UK and international biomedical communities, we will: hold joint workshops with other UK RMP hubs/annual Symposium, all open to hub members, national (UK RMP hub) and international colleagues, thus strengthening UK standing in international stem cell networks; participate at a high level in major national and international conferences where we will report our scientific discoveries and translational advances; disseminate our data in high-impact scientific journals. Thus contributing prominently to the evelopment of a world-leading UK 'brand' in tissue regeneration and repair. 2. Biopharma and Translation: Stem cells offer great hope but have so far delivered only relatively modest benefits worldwide, with few cell-based and no drug-based regenerative strategies in the clinic to meet the huge demand. Our philosophy is that major clinical advances in tissue regeneration will only be possible once address the "soil" - the environment within which we wish to "seed" stem cells to promote repair. We will exploit new understanding of how the niche environment directs stem/progenitor cell phenotype, function and fate, and drives tissue formation in health and in disease. Thus our research will be of interest to industry, e.g. in the development of niche-based products and tools such as stem cell selection systems, marker arrays, lineage pathway inducers, natural epitope-derived biomaterials and extracellular matrix products. Hub members are already directly involved in marketing new products such as EpranEx microtitre plates to analyse protein-glycan interactions (UoMan) and novel polymer substrates to promote hepatocyte differentiation (FibromEd, UoE), and we are developing a range of novel biomaterials based on these and other bioengineering technologies. All our Universities have strong records of exploiting innovative research findings through commercialisation of intellectual property (e.g. UoM Intellectual Property (UMIP) and Edinburgh BioQuarter). Outputs for exploitation will be selected by the Management Committee, with a decision made on the appropriate host University to lead commercialisation activity of research products (based on balance of IP): these may include licensing of cellular and extracellular matrix reagents/biologics and protocols, provision of research expertise such as iPS cells or or glycomic technologies, novel lineage-inducing small molecules, in-house assays/technologies, co-development of technologies licensing of IP, consultancies.

Publications

10 25 50
 
Title Front cover of Best of Stem Cell Reports 2016 
Description Image provided was used to create a collage 
Type Of Art Image 
Year Produced 2016 
Impact Views on ResearchGate 
URL https://www.researchgate.net/publication/304988615_Best_of_Stem_Cell_Reports_2016_Front_Cover_Image
 
Description Presentation to Government Science and Technology Committee (Forbes and Hollander)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Royal Society of Biology training for teachers
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Biology teachers in Scotland trained in multiple sclerosis and stem cell knowledge. Important for their coursework with children
 
Description CSO Funding
Amount £300,000 (GBP)
Organisation Government of Scotland 
Sector Public
Country United Kingdom
Start 06/2017 
End 05/2019
 
Description EPSRC
Amount £1,000,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 02/2020
 
Description GSK
Amount £350,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 01/2015 
End 12/2016
 
Description Innovate UK
Amount £831,782 (GBP)
Funding ID 93592-562428 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2019
 
Description MRC Confidence in Concept
Amount £85,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 09/2018
 
Description MRC DPFS
Amount £2,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2017 
End 04/2021
 
Description MRC Regenerative Medicine Committee
Amount £300,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 03/2019
 
Description MS Society Innovative grant
Amount £40,000 (GBP)
Organisation Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2015
 
Description Multiple Sclerosis Society UK Project Grant
Amount £300,000 (GBP)
Organisation Multiple Sclerosis Society 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2019
 
Description UKRMP Hub: The Engineered Cell Environment.
Amount £4,097,857 (GBP)
Funding ID MR/R015635/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 03/2023
 
Title AhCreMdm2 flox, inducible mouse model for liver injury 
Description AhCreMdm2 flox, inducible mouse model for liver injury 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2017 
Provided To Others? Yes  
Impact Further funding has been leveraged thanks to results generated using this mouse model. 
 
Title Cost effective protocols for growing hepatocyte like cells from human pluripotent stem cells suitable for mass production of clinical grade cells 
Description Cost effective protocols for growing hepatocyte like cells from human pluripotent stem cells suitable for mass production of clinical grade cells 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2015 
Provided To Others? Yes  
Impact Linked to NC3RS aims and objectives. IP linked to protocol licensed to Biolamina. 
 
Title Defined Production of Hepatocyte Like Cells from Pluripotent Stem Cells 
Description Defined system for producing hepatocytes 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact Protected patent, exclusively licensed to industry for commercial exploitation 
URL http://www.freepatentsonline.com/y2017/0121686.html
 
Title Drug toxicity screening assay 
Description Tools for drug toxicity screening based on stem cell derived hepatocytes 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Industrial collaboration with Astra Zeneca 
 
Title ES chondrogenic Platform 
Description ES chondrogenic Platform 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact ES chondrogenic Platform 
 
Title GFP labelled human ESCs 
Description Human ESCs were labelled with GFP using lentiviral vector. 
Type Of Material Cell line 
Provided To Others? No  
Impact These cells could be used for studies requiring tracing cell migration or destination. 
 
Title Geneation of ECM pepetides 
Description Laminin a5 chain fragments LG1-LG3, LG4-LG5, and LG1-LG5 from new constructs (developing for yield. Fibronectin 29kD fragment form trypsin digest of full length recombinant fibronectin 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact none yet 
 
Title Hetero spectral lipidiomics workflow for biomolecular profiling of remyelination in multiple sclerosis 
Description Hetero spectral lipidiomics workflow for biomolecular profiling of remyelination in multiple sclerosis 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2018 
Provided To Others? Yes  
Impact Hetero spectral lipidiomics workflow for biomolecular profiling of remyelination in multiple sclerosis 
 
Title High throughput semi-automated stem cell derived hepatocyte differentiation protocol 
Description High throughput semi-automated stem cell derived hepatocyte differentiation protocol 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? No  
Impact High throughput semi-automated stem cell derived hepatocyte differentiation protocol 
 
Title High throughput, high content imaging platform to evaluate "hepatocyteness" of cells 
Description High throughput, high content imaging platform to evaluate "hepatocyteness" of cells 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact High throughput, high content imaging platform to evaluate "hepatocyteness" of cells 
 
Title Inducible lentiviral vectors 
Description • 3rd Generation tet inducible vector with EF1a promoter and tagBFP reporter. • 3rd Generation tet inducible vector with EF1a promoter and iRFP720 reporter 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact Cell labelling and delivery reagents 
 
Title Lentiviral reporter vectors 
Description • Lentiviral wnt reporter with nanoLUC and tagRFP reporters and copGFP selection • Collagen 2 reporter with SOX9 reporter element. Nanoluc and tagRFP repoters and copGFP selection • BMP Reporter with nanoluc and RFP reporter and GFP selection 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact Cell labelling and delivery reagents 
 
Title Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells. 
Description Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2018 
Provided To Others? Yes  
Impact Transferred to industry non-exclusively 
URL https://www.ncbi.nlm.nih.gov/pubmed/29786565
 
Title Online quantitative monitoring of live cell engineered cartilage growth using diffuse fibre-optic Raman spectroscopy 
Description Online quantitative monitoring of live cell engineered cartilage growth using diffuse fibre-optic Raman spectroscopy 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2017 
Provided To Others? Yes  
Impact Online quantitative monitoring of live cell engineered cartilage growth using diffuse fibre-optic Raman spectroscopy 
 
Title Protocol for cryopreservation of HPCs 
Description Protocol for cryopreservation of HPCs 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact Protocol for cryopreservation of HPCs 
 
Title Protocol for differentiation of ECs from iPSCs 
Description Protocol for differentiation of ECs from iPSCs 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2017 
Provided To Others? Yes  
Impact Protocol for differentiation of ECs from iPSCs 
 
Title Protocol for enhanced human liver stem cell growth (proliferative and stability) 
Description Protocol for enhanced human liver stem cell growth (proliferative and stability) 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? No  
Impact Protocol for enhanced human liver stem cell growth (proliferative and stability) 
 
Title Protocol for expansion of stable human HPCs 
Description Protocol for expansion of stable human HPCs 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? No  
Impact Protocol for expansion of stable human HPCs 
 
Title Protocol for isolation of viable human HPCs from transplant rejected liver 
Description Protocol for isolation of viable human HPCs from transplant rejected liver 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? No  
Impact Protocol for isolation of viable human HPCs from transplant rejected liver 
 
Title Protocol for serum-free chondrocyte differentiation from hESCs 
Description Protocol for serum-free chondrocyte differentiation from hESCs 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? No  
Impact Protocol for serum-free chondrocyte differentiation from hESCs 
 
Title Protocol to measure Raman images of tissue-engineered cartilage 
Description Protocol to measure Raman images of tissue-engineered cartilage 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact Protocol to measure Raman images of tissue-engineered cartilage 
 
Title Quantitative volumetric Raman imaging of 3D cell culture 
Description Quantitative volumetric Raman imaging of 3D cell culture 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact Quantitative volumetric Raman imaging of 3D cell culture 
 
Title Raman spectroscopy platform for analysis of zonal organisation of cartilage 
Description Raman spectroscopy platform for analysis of zonal organisation of cartilage 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2017 
Provided To Others? Yes  
Impact Raman spectroscopy platform for analysis of zonal organisation of cartilage 
 
Title Raman spectroscopy protocol for the integration and analysis of multiple analytical datasets 
Description Raman spectroscopy protocol for the integration and analysis of multiple analytical datasets 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact N/A 
 
Title Remyelination assay 
Description Screening strategies for remyelination 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Ongoing discussions with several pharma companies with regards to collaborating. 
 
Title Repair of cartilage defect in sheep 
Description Development of method to repair osteochondral defect in a large animal 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact No impact yet but paper will be written shortly 
 
Title Screening strategies for chondrogenesis 
Description Screening strategies for chondrogenesis 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Screening strategies for chondrogenesis 
 
Title Screening strategies for endogenous liver regeneration 
Description Screening strategies for endogenous liver regeneration 
Type Of Material Technology assay or reagent 
Year Produced 2016 
Provided To Others? No  
Impact Screening strategies for endogenous liver regeneration 
 
Title Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells 
Description Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact The technology has been transferred to industry partners non-exclusively 
URL https://www.ncbi.nlm.nih.gov/pubmed/30102283
 
Title Six Clinical grade Manchester hESC lined completed due diligence and made avialble by UKSCB 
Description Manchester Clinical grade hESCs now registered as EUCTD compliant and launched by Stem Cell bank 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2017 
Provided To Others? Yes  
Impact Provision at research grade lines in in 2015. Lead to several papers from Hay and Kunath groups. Now available as clinical grade though UKSCB 
 
Title Techniques for measurement of lead microRNAs in patients with acute liver injury 
Description Techniques for measurement of lead microRNAs in patients with acute liver injury 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Work is ongoing with regards to developing a point of care diagnostic for the diagnosis of paracetamol overdose. 
 
Title Validated extracellular matrix (ECM) arrays 
Description A range of high quality ECM products are available in order to support the bespoke niche products for preclinical research and therapeutic development 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact Multiple research groups are using the ECM material and are producing multiple publications detailing the outputs. 
 
Title Xeno-free cell culture media 
Description Xeno-free cell culture media for 2D/3D differentiation of hepatocytes 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Development of a scalable sustainable protocol for the differentiation of hepatocytes in both a 2D and 3D environment 
 
Title Stem cell differentiation bioinformatics 
Description Comparing gene expression of adult human hepatocytes to stem cell derived hepatocytes 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact Other researchers around the world using this system as reference - Godoy et al Archives of Toxicol 2016, Mallanna et al 2016 Stem Cell Reports 
URL https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-3994/
 
Description Astellas Institute for Regenerative Medicine Collaboration 
Organisation Astellas Pharma
Department Astellas Pharma UK
Country United Kingdom 
Sector Private 
PI Contribution Screening small molecule libraries
Collaborator Contribution Provision of library
Impact Confidential
Start Year 2018
 
Description AstraZeneca and Dave Hay Collaboration: Toxicity Testing 
Organisation AstraZeneca
Department Toxicology Sciences
Country United Kingdom 
Sector Private 
PI Contribution Provided screening platform/technology that had been developed during UKRMP funded research.
Collaborator Contribution AZ provided a library of compounds for testing as well as AZ generated data for comparative purposes
Impact Plans for joint publication of results. Screening platform currently being investigated a spin out opportunity. PDRA has been awarded an RSE Fellowship to pursue this opportunity.
Start Year 2016
 
Description Collaboration Tamir Rashid & NPSC 
Organisation Janssen Research & Development
Country Global 
Sector Private 
PI Contribution Rashid group are transferring their assay for alpha-trypsin-1 deficiency to NPSC for HTS purposes
Collaborator Contribution National Phenotypic Screening Centre and Janssen are providing high through put capabilities and compound libraries.
Impact Ongoing - no outputs as yet.
Start Year 2017
 
Description Collaboration Tamir Rashid & NPSC 
Organisation National Phenotypic Screening Centre
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Rashid group are transferring their assay for alpha-trypsin-1 deficiency to NPSC for HTS purposes
Collaborator Contribution National Phenotypic Screening Centre and Janssen are providing high through put capabilities and compound libraries.
Impact Ongoing - no outputs as yet.
Start Year 2017
 
Description Collaboration between Prof Stuart Forbes and Novartis Institute of Biomedical Research 
Organisation Novartis Institutes for BioMedical Research (NIBR)
Country United States 
Sector Private 
PI Contribution Cell lines and methods generated using UKRMP funded research are being provided to Novartis.
Collaborator Contribution In house expertise from NIBR
Impact No outcomes as yet but the aim is to produce a screen for regeneration cues for HPCs using a CRISPR-Cas9 assisted system.
Start Year 2016
 
Description Collaboration with Xintela Sweden 
Organisation Xintela AB
Country Sweden 
Sector Private 
PI Contribution Collaboration to enhance chondrogeneis from hESCs using extracellular matrix modulation
Collaborator Contribution We have the protocol and cells they have specific required antibodies
Impact Only just initiated
Start Year 2014
 
Description GAG analysis with Keele/Oswestry 
Organisation Keele University
Department School of Law
Country United Kingdom 
Sector Academic/University 
PI Contribution We have a protocol for chondrogenesis . Nicky Kuipper at Keele Oswestry will analyse GAGS in medium and cells for preliminary data for a grant application
Collaborator Contribution FACE and other analyses
Impact analyses of samples in progress
Start Year 2016
 
Description GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Idea Screening New model
Collaborator Contribution Finances small molecules
Impact Too early
Start Year 2014
 
Description Generation of dynamic substrates that mimic changed in the epidermal/dermal interface 
Organisation Keele University
Country United Kingdom 
Sector Academic/University 
PI Contribution My BBSRC-funded research assistant is working with Alicia El Haj's team to develop the substrates. My lab benefits from Alicia's expertise and access to her workshop to manufacture components of the experimental setup.
Collaborator Contribution See above.
Impact Research in progress
Start Year 2015
 
Description Genzyme and Scott Webster 
Organisation Sanofi
Department Genzyme Corporation
Country United States 
Sector Private 
PI Contribution Scientific idea Drug target
Collaborator Contribution High throughput screening technology Assay development
Impact Too early. (Just started)
Start Year 2014
 
Description KCL Stem Cell Hotel Concierge Position 
Organisation Perkin Elmer
Country United States 
Sector Private 
PI Contribution Establishment of Stem Cell Hotel within Centre for Stem Cells and Regenerative Medicine at KCL.
Collaborator Contribution Funding for Stem Cell Hotel Concierge (technician) plus equipment maintenance and servicing contracts.
Impact Skills and expertise provided to KCL.
Start Year 2016
 
Description KCL and Materiomics Topochip Study 
Organisation Materiomics
Country Netherlands 
Sector Private 
PI Contribution Development of screen for features that promote differentiation of human epidermal keratinocytes.
Collaborator Contribution Provision of platform technology.
Impact Screen which potential clinical applications
Start Year 2016
 
Description Liver on a chip commercilisation 
Organisation Stemnovate Limited
PI Contribution Stemnovate have non exclusively licensed our stem cell derived hepatocyte technology. We will provide know how and training.
Collaborator Contribution Financial contribution to a PhD programme - *BBSRC EASTBIO* Modelling foetal liver development and disruption using pluripotent stem cells (iCase)
Impact In the process of interviewing
Start Year 2017
 
Description Miltenyi 
Organisation Miltenyi Biotec GmBH
Country Germany 
Sector Private 
PI Contribution We have submitted a large grant application to Arthritis Research Uk with Miltenyi. If successful they will contribute in kind support with cell sorting and GMP translationof our protocol for clinical therapy
Collaborator Contribution Cell sorting expertise and kits/antibodies/plates for FACs based cell sorting for enrichment of chondroprogenitors
Impact Too early
Start Year 2017
 
Description OPC migration assays 
Organisation University of Strathclyde
Department Department of Civil and Environmental Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Instigator We have the biological idea and Michele Zagnoni has the technology to do the work. cells to put in the assay. Knowledge on biology.
Collaborator Contribution Microfluidics technology to do the work.
Impact ARUK pilot grant FISM fellowship to Roberta Felici FISM small project grant to Michele Zagnoni (co-applicant)
Start Year 2015
 
Description Roche 
Organisation F. Hoffmann-La Roche AG
Country Global 
Sector Private 
PI Contribution Work on MS tissue
Collaborator Contribution Financial support for this work
Impact Paper in Nature 2019
Start Year 2018
 
Description SnRNAseq 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Collaboration between us (MS neuropathology and biology experts) and Goncalo Castelo-Branco (experts in snRNAseq and analysis)
Collaborator Contribution Collaboration between us (MS neuropathology and biology experts) and Goncalo Castelo-Branco (experts in snRNAseq and analysis)
Impact Nature Medicine and Nature paper 2018 and 2019
Start Year 2017
 
Title Identifying organ damage 
Description The present invention provides methods for identifying whether or not a patient has, or is at risk of developing drug induced organ damage and methods of treating patients having drug induced organ damage. In particular, the invention relates to a method for identifying whether or not a patent has, or is at risk of developing paracetamol induced liver damage. 
IP Reference WO2009027703 
Protection Patent application published
Year Protection Granted 2009
Licensed Yes
Impact Several different industrial collaborations have arisen as a result of this patent including diagnostic development, therapeutic development as a cure for paracetamol overdose and technology development for primary care.
 
Title METHODS FOR PRODUCING HEPATOCYTES 
Description Methods for producing hepatocytes from pluripotent human stem cells are disclosed herein. The stem cells are plated on a cell culture substrate comprising two laminins. The stem cells are then exposed to different cell culture mediums to induce differentiation. The resulting hepatocytes have higher metabolic capacity compared to hepatocytes cultured on different substrates. 
IP Reference US20170121686 
Protection Patent application published
Year Protection Granted 2016
Licensed Yes
Impact IP was licensed to Biolamina along with the joint filing of the patent between the University of Biolamina. The IP has since been sub-licensed to another commercial organisation for the purposes of producing hepatocyte differentiation kits. Biolamina are also in discussion with other organisations regarding licensing of the technology for other purposes e.g. toxicity screening.
 
Company Name CYTOCHROMA LIMITED 
Description Cytochroma's high throughput, automated screening platform delivers accurate toxicity information. From cell culture, to compound addition, all the way to data analysis and delivery. The Cytochroma assay is more sensitive than current cell health based assays and delivers significantly more information. It is fully customisable, at each step delivering all the data needed. 
Year Established 2017 
Impact Dr Kate Cameron is fully funded by the BBSRC (Biotechnology and Biological Sciences Research Council) as one of the high prestigious Royal Society of Edinburgh Enterprise Fellowships. In the past few months she was awarded the highest amount possible, and special Higgs prize by Scottish EDGE in June. She came second in UoE annual competition Inspire Launch Grow awards and more recently, in September she placed in the top 2.5% of entrants, in the Converge Challenge. Funding and support from UoE, RSE + BBSRC has supported the lease of laboratory and office facilities at Roslin Innovation Centre, where she is currently based.
Website http://www.cytochroma.uk/
 
Description 12th International Conference on Materials Chemistry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact There was good input/feedback afterwards, along with several fruitful discussions.

This was an exciting meeting, and the collaborative discussions were good in general.
Year(s) Of Engagement Activity 2015
 
Description 13th European Symposium on Controlled Drug Delivery in Egmond aan Zee, The Netherlands 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Molly Stevens' opening lecture "Designing Nanomaterials for Biosensing", followed by discussion

"Bench to market" Knowledge exchange
Year(s) Of Engagement Activity 2014
URL http://www.escdd.eu/
 
Description 1st Joint meeting of the British Society for Matrix Biology and Developmental Biology 1-3 September 2014 Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Professor Sue Kimber: Oral presentation ('Differentiation of Chondrocytes from Pluripotent Stem Cells for Cartilage repair') and poster presentation ('Cartilage repair using human embryonic stem cell-derived chondroprogenitors').
Professor Cay Kielty: Oral presentation ('Genotype-phenotype in the fibrillinopathies')

PDF version of poster is available for the hub
Year(s) Of Engagement Activity 2014
URL http://www.bsmb.ac.uk/bsmb-bsdb/
 
Description 2014 MRS Spring Meeting and Exhibit, April 21-25 2014, San Francisco (California) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Molly Stevens acted as one of the meeting chairs. Diverse meeting topics ensured engagement of scientists and practitioners from different disciplines and backgrounds

Cross-disciplinary knowledge sharing
Year(s) Of Engagement Activity 2014
URL http://www.mrs.org/spring2014/
 
Description 2014 eCM XV: Cartilage & Disc: Repair and Regeneration. AO Research Institute, Davos (Switzerland) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Sue Kimber (keynote speaker): "Pluripotent Stem Cells for Cartilage repair", followed by discussion.

Scientists and clinicians together addressed the clinical challenges of articular cartilage and intervertebral disc repair
Year(s) Of Engagement Activity 2014
URL http://www.ecmjournal.org/ecm_meetings/ecm_15/
 
Description 2016 International Symposium on Nanobiotechnology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This symposium had an excellent focus on nanomaterials and nanotechnologies! Several terrific researchers from around the world attended.
Year(s) Of Engagement Activity 2016
 
Description 2nd BIRAX Regenerative Medicine Conference, March 25-26 2014, Haifa, Israel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professors Sue Kimber (Understanding chondrogenesis from pluripotent stem cells in vitro ) and Cay Kielty (Microenvironmental control of mesenchymal stromal cell fate) contributed to parallel sessions on 'Convergence of Cell and Gene Therapies' and 'Rejuvenation of endogenous stem cells', respectively.

The conference brought together leading scientists from the UK and Israel in the field of Regenerative Medicine to share latest developments in the field and to develop collaborations.
Year(s) Of Engagement Activity 2014
URL http://www.britishcouncil.org.il/en/2nd-BIRAX-conference
 
Description 4th TERMIS World Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Good conference with several world-leading scientists present.

Good collaborative talks in a great environment - really positive conference!
Year(s) Of Engagement Activity 2015
 
Description ASME 2014 3rd Global Congress on NanoEngineering for Medicine and Biology,Feb. 2-5, 2014, San Francisco, CA. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Molly Stevens keynote presentation "New Materials-Based Approaches for Regenerative Medicine"

Integration of Engineering, Materials Science, and Nanotechnology in addressing fundamental problems in Biology and Medicine and in developing devices, materials and methods for quantitative physiology and for the early detection, imaging of pathological and physiological mechanisms, and treatment of disease.
Year(s) Of Engagement Activity 2014
URL http://www.asmeconferences.org/nemb2014/
 
Description Adam Neville Lecture at the University of Dundee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Great discussions afterwards with several peers.

Met some students interested in the area.
Year(s) Of Engagement Activity 2015
 
Description Advances and Applications of Functional Hepatocytes (AAFH) Symposium, Oct 29-30, 2014 Shanghai (China) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr. David Hay presented "Modelling Human Biology With Pluripotent Stem Cell Derived Hepatocytes"

The symposium brought research, industry and clinic together to update the latest achievements in sources and applications of hepatocyte-like cells, advancing goals of integrating latest technical progresses, bridging the demands from clinic and industry, and addressing some urgent problems in these areas
Year(s) Of Engagement Activity 2014
URL http://aafh.cscb.org.cn/
 
Description Advice for applicants for Wellcome Trust Sir Henry Dale Fellowships http://elifesciences.org/elife-news/webinar-report-Sir-Henry-Dale 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Advice to postdocs on obtaining a career development award.
Year(s) Of Engagement Activity 2016
URL http://elifesciences.org/elife-news/webinar-report-Sir-Henry-Dale
 
Description Australian Health and Medical Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Good discussions on biomaterials-based approaches in regenerative medicine.

The audience was interactive and there were several good discussions afterwards.
Year(s) Of Engagement Activity 2014
 
Description BSCR and BSGCT Joint Meeting: Cell therapy for cardiovascular disease in the 21st century: a reflective and prospective update 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Good summary of the current status and future direction(s) of cell-based therapies in regenerative medicine.

Nice discussions with other colleagues/researchers.
Year(s) Of Engagement Activity 2015
 
Description BSMB-BRS 3rd Joint Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact There were good discussions around the state of materials for applications in regenerative medicine.

I met some enthusiastic students amongst the collaborative discussions.
Year(s) Of Engagement Activity 2015
 
Description Bold in Blue Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Good discussion afterwards.

After my talk, many people bought cakes from the stand and took away information on MS and stem cells.
Year(s) Of Engagement Activity 2014
 
Description Building The Extracellular Matrix: Molecules, Cells and Evolution. BSCMB Spring Meeting, April 7-8 2014, Bristol 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Cay Kielty presented ""Fibrillins and LTBPs: structural and growth factor regulatory roles"

The meeting focused on mechanisms and processes in Cell-ECM interactions and signaling, ECM structures and niches, and ECM-growth factor interactions.
Year(s) Of Engagement Activity 2014
URL http://www.bsmb.ac.uk/meetings-index/building-the-extracellular-matrix-molecules-cells-and-evolution...
 
Description Cold Spring Harbor Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International conference
Year(s) Of Engagement Activity 2016
 
Description Corday-Morgan Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This talk was an acceptance of my winning the Corday-Morgan Award.

Recognition of excellence in chemical research: Corday-Morgan Award from the Royal Society of Chemistry.
Year(s) Of Engagement Activity 2015
 
Description Creating a New Gold Standard Model for Hepatotoxicity - A Pharma iQ Interview with David Hay 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Thought-provoking insights from leading Regen Med researcher

Increased interest/awareness in pharma community
Year(s) Of Engagement Activity 2014
URL http://www.pharma-iq.com/pre-clinical-discovery-and-development/articles/creating-a-new-gold-standar...
 
Description EBI-Sanger-Cambridge PhD Symposium (eSCAMPS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This symposium had an excellent agenda/programme; several terrific discussions on research activities followed.
Year(s) Of Engagement Activity 2016
 
Description EMBO Workshop "Stem cell mechanobiology in development and disease" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was an excellent workshop, and several collaborative discussions followed this event.
Year(s) Of Engagement Activity 2015
 
Description El Haj Presentation at Hay Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Part of a Royal Society Event to encourage debate and discussion.
Year(s) Of Engagement Activity 2017
 
Description Fife MS group visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Visit for lerning about MS research and for informing young scientists about what it is like to have MS.

Students very positive about inspiration and motivation gained from talking to MS patients.
Year(s) Of Engagement Activity 2014
 
Description Focus (National Insurers society), Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Focus (National Insurers society), Edinburgh - talk about MS to insurance companies looking at critical illness payouts. Relaxation in requirements by insurers likely.
Year(s) Of Engagement Activity 2016
 
Description Fourth International Sympsoium Frontiers in Polymer Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact There were several good scientists in polymer scientists present - good discussions.

I met with several potential collaborators in the field.
Year(s) Of Engagement Activity 2015
 
Description GRC: Self-Assembly and Supramolecular Chemistry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Great assembly of world-leading scientists at this GRC: terrific discussions!

I discussed with a number of collaborators in a great setting.
Year(s) Of Engagement Activity 2015
 
Description George Watson's School Science Club guest speaker, Edinburgh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact George Watson's School Science Club guest speaker, Edinburgh- interest in MS from them
Year(s) Of Engagement Activity 2016
 
Description Gordon Research Conference • Biointerface Science, Il Ciocco, Italy, 15-20 June 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Molly Stevens presentation and discussion "Investigating and Engineering the Cell-Material Interface"

New insights shared among practitioners
Year(s) Of Engagement Activity 2014
URL http://www.grc.org/programs.aspx?year=2014&program=biointerf
 
Description Gordon Research Conference: Signaling by Adhesion Receptors, June 22-27 2014, Maine (USA) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Cay Kielty presentation "Microenvironmental Regulation of Mesenchymal Stem Cell Fate" , followed by discussion

Sharing new unpublished findings on adhesion signaling in all of the most actively researched topic areas
Year(s) Of Engagement Activity 2014
URL http://www.grc.org/programs.aspx?year=2014&program=sigadhes
 
Description Grangemouth MS society Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Participants in your research and patient groups
Results and Impact Invited to the regional MS society monthly meeting to provide a research talk. Many questions afterwards.

Visit of MS society group to our institute to see the building and speak to young scientists working in MS research.
Year(s) Of Engagement Activity 2014
 
Description Habib Presentation at Pint of Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation to spark questions and discussion.
Year(s) Of Engagement Activity 2017
 
Description Harvard SEAS Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was an excellent seminar at an excellent venue. I was able to continue collaborative discussions with several world-class scientists and researchers.
Year(s) Of Engagement Activity 2015
 
Description ISSCR 12th Annual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Several UKRMP Niche Hub PIs participated / presented at this major conference. Meeting Program Committee chaired by Professor Fiona Watt

Knowledge sharing among practitioners of stem cell and regenerative medicine research
Year(s) Of Engagement Activity 2014
URL http://www.isscr.org/home/annual-meeting/2014annualmeeting/recap
 
Description Industry Engagement Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A half day workshop highlighting engagement opportunities with UKRMP and MRC CRM researchers.
Year(s) Of Engagement Activity 2017
 
Description International Conference on Regenerative Biomedical Materials 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Good feedback after talk - nice discussions afterwards.

I met a good group of potential collaborators.
Year(s) Of Engagement Activity 2015
 
Description International Institute for Nanotechnology Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Talk well received - several discussions afterwards.

Met several students/possible collaborators - good discussions.
Year(s) Of Engagement Activity 2014
 
Description Interviews for YouTube for Shift-MS webpage - MS patient interviewing me. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Interviews for YouTube for Shift-MS webpage - MS patient interviewing me.

Information to MS community
watch here:
https://www.youtube.com/watch?v=6bFJwWKkSd8
https://www.youtube.com/watch?v=9KiUM
https://www.youtube.com/watch?v=ro8VT32vjyM
Year(s) Of Engagement Activity 2016
URL http://www.youtube.com/watch?v=6bFJwWKkSd8
 
Description Joint ChemE/BME Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Good seminar: there were several researchers from Imperial College, with whom I could progress research further along.
Year(s) Of Engagement Activity 2015
 
Description Journal of Internal Medicine (JIM) Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation keynote/invited speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This symposium was very successful in stimulating discussions with several collaborators, some new and several long-standing within Sweden.

Good discussions followed the presentation.
Year(s) Of Engagement Activity 2015
 
Description KCL One Nucleus BioWednesday Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Networking evening event to encourage collaboration.
Year(s) Of Engagement Activity 2017
 
Description Life Technologies 2nd Annual '24 hours of stem cells' online event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Pre-recorded on demand presentation "Deriving functional hepatocytes from pluripotent stem cells"

Knowledge diffusion
Year(s) Of Engagement Activity 2014
URL http://resource.lifetechnologies.com/pages2014/WE218203/
 
Description Live Facebook Reuters Interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Live Facebook interview after Cafe Scientifique event organised by the Royal Society
Year(s) Of Engagement Activity 2016
 
Description London Polymer Network (Plenary Talk) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact This network supported good disucssions amongst several leaders within the field.

I caught up with several peers/colleagues, while I met a number of enthusiastic students.
Year(s) Of Engagement Activity 2015
 
Description MBE (Matrix Biology Europe) conference 21 - 24 June 2014, Rotterdam (Netherlands) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor cay Kielty presentation "The effect of fibrillin mutations: Altered TGF-beta and heparin binding results in a variety of connective tissue diseases" in workshop on 'advances in understanding matrix disease mechanisms'.

Senior and young scientists and scholars participated in order to:
- Communicate the results of their recent research
- Experience research presentations across the broad spectrum of matrix biology
- Exchange ideas and to argue alternate interpretations through informal discussion
- Establish friendships and renew old friendships
Year(s) Of Engagement Activity 2014
URL http://www.mbe2014.eu/home
 
Description MRC Festival of Medical Sciences 25th June 2018 - CRMat10 Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact A reception to celebrate 10 years of the Centre. Presenters included directors, staff, students and community partners. It was attended by a long standing donor of the Centre, one of the first PhD students and our local community school partners. Awards recognised significant contributions to the MRC CRM over the past 10 years and included past and present members of the professional services team. Staff commented that they found the event inspiring and appreciated its inclusiveness. The event generated a lot of interest on social media
160 Engagements for one Twitter post https://twitter.com/crm_edinburgh/status/1010208591712870401
204 Engagements for one Facebook post https://www.facebook.com/CentreForRegenerativeMedicine/posts/1691853487599976
This is well above average for our social media channel and among the top 3 posts in the year.
Year(s) Of Engagement Activity 2018
URL http://www.crm.ed.ac.uk/CRMat10awards
 
Description MRC Millennium Medal Showcase at Houses of Parliament 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Making MPs aware of MRC funded research and the impact it could have.
Year(s) Of Engagement Activity 2018
 
Description MRS Fall Meeting (2015) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This MRS talk was delivered to a large audience, and I connected with several collaborators/researchers from across the globe.
Year(s) Of Engagement Activity 2015
 
Description MRS Spring Meeting and Exhibit (2015) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact There were several world-leading scientists present: great collaborative discussions.

I connected again with a number of collaborators, while I met a number of good students.
Year(s) Of Engagement Activity 2015
 
Description MS society Borders Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Discussion amongst participants

Interest in visiting lab.
Year(s) Of Engagement Activity 2013
 
Description Mercia Stem Cell Alliance (MSCA) Annual scientific meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Poster presentation (Cartilage repair using human embryonic stem cell-derived chondroprogenitors). Facilitated the essential development and promotion of stem cell research in the region.

Provided opportunities for PhD students and postdocs to present their research via oral presentation, poster and poster teaser talk
Year(s) Of Engagement Activity 2014
 
Description Nanotechnology and Medicines for Tomorrow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Good discussions about nanomaterials and the field of nanotechnology.

There were several discussions with possible (and current) collaborators.
Year(s) Of Engagement Activity 2014
 
Description New Frontiers in Regenerative Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Good audience focusing on regenerative medicine; good overview of our research programme.

Nice discussions afterwards on a broad range of topics.
Year(s) Of Engagement Activity 2014
 
Description Poster presented at launch of Manchester Regenerative Medicine Network 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Poster presentation at launch of Manchester Regenerative Medicine Network event
Year(s) Of Engagement Activity 2016
 
Description Presentation at Cafe Scientific organised by the Royal Society 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique - promotion of UKRMP Hub and projects
Year(s) Of Engagement Activity 2016
 
Description Presentation at Future Investigators of Regenerative Medicine (FIRM) Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at FIRM, Spain 2016
Year(s) Of Engagement Activity 2016
 
Description Presentation to MSc students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Lecture/presentation to MSc students
Year(s) Of Engagement Activity 2016
 
Description Press release: Stem cell liver implants show promise 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release from CRM resulting in media coverage on websites and in newspapers.
Scottish Daily Mail
https://www.pressreader.com/uk/scottish-daily-mail/20180828/281977493484972
Online
https://www.fiercebiotech.com/research/growing-human-stem-cells-into-functional-3d-liver-tissue
https://www.rdmag.com/article/2018/08/new-liver-tissue-implants-showing-promise
MRC website
https://mrc.ukri.org/news/browse/liver-tissue-implants-show-promising-support-of-liver-function/
Year(s) Of Engagement Activity 2018
URL http://www.crm.ed.ac.uk/news/stem-cell-liver-implants-show-promise
 
Description Prof. Molly Stevens Plenary lecture Nanobio Australia 2014 (Brisbane) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact NanoBio Australia 2014 featured a diverse array of multi-disciplinary science designed to connect world-leading scientists, engineers and entrepreneurs working in this space.

expansion / enhancement of knowledge networks
Year(s) Of Engagement Activity 2014
URL http://www.icbni.com.au/
 
Description Professor Fiona Watt's contribution to the promotion of Stem Cell and Regenerative Medicine research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Wide dissemination of knowledge and understanding of stem cell and regenerative medicine research

KCL award for "Most Outstanding Contribution to Public Engagement"
Year(s) Of Engagement Activity 2014
URL http://www.wattlab.org/news-archive.html
 
Description Public lecture "Let's talk about Health Series", University of Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Public lecture "Let's talk about Health Series", University of Edinburgh

Patients and carers came to be informed about new research. Enjoyed it.
Year(s) Of Engagement Activity 2016
URL https://media.ed.ac.uk/media/1_0sjjffai
 
Description RSE Lecture: Innovation in Organ Transplantation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Lecture given at Royal Society of Edinburgh: Innovation in Organ Transplantation
Year(s) Of Engagement Activity 2018
 
Description Ratho MS AGM 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact Discussion afterwards

Visit being arranged for MS Fife group to come to the institute and see the research and speak to young scientists working in MS
Year(s) Of Engagement Activity 2014
 
Description Royal Society of Biology, Edinburgh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Royal Society of Biology, Edinburgh - to biology teachers in Scotland. Change their teaching content.
Year(s) Of Engagement Activity 2016
 
Description Royal Society public lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Live streamed public lecture, followed by questions and discussion. Video available

Knowledge sharing and building of public understanding of stem cells and regenerative medicine
Year(s) Of Engagement Activity 2014
URL https://royalsociety.org/events/2014/stem-cells/
 
Description Royal Society-IBS Research Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Nice conference: met several students and researchers in the field.

Good summary of the field and collaborative discussions.
Year(s) Of Engagement Activity 2014
 
Description Scientists find that smoking harms livers of unborn babies 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Two radio interviews
Year(s) Of Engagement Activity 2017
URL https://www.bbc.co.uk/news/uk-scotland-40084844
 
Description Secondary school teachers teaching about white matter disease 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Teaching of around 20 biology teachers at secondary schools across Scotland about brain diseases. Interest about these diseases (part of curriculum) and personal interest as many people have friends or family with dementia or MS.
Year(s) Of Engagement Activity 2017
 
Description ShanghaiTech Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact A good round of discussions followed afterwards.

There were several colleagues present; nice discussions within the field.
Year(s) Of Engagement Activity 2015
 
Description Stem Cell Research: From Utopian Dream to Reality (2016) https://www.youtube.com/watch?v=JIqULf7xJ90&feature=em-subs_digest 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Exhibition and video as part of 'Utopia 2016' exhibition at Somerset House.
Year(s) Of Engagement Activity 2016
URL http://www.youtube.com/watch?v=JIqULf7xJ90&feature=em-subs_digest
 
Description Stem Cells and Regenerative medicine from chondrocytes to kidneys 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk on Regenerative medicine to U3A members
Year(s) Of Engagement Activity 2018
 
Description Stem cell 'advance' hailed by scientists 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Patented procedure to generate hepatocytes from stem cells - http://www.freepatentsonline.com/y2017/0121686.html
Year(s) Of Engagement Activity 2015
URL https://www.pressreader.com/uk/the-herald/20151126/281908772057947/TextView
 
Description Swedish Chemical Society Berzelius Days Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This lecture was important for reconnecting with several researchers and clinical collaborators within Sweden.
Year(s) Of Engagement Activity 2016
 
Description Translate! 2014 Open Forum for Translational Research, Berlin, Germany, May 23rd 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Molly Stevens presented "Technology-driven Translational Research:Does Material Science ever Meet a Medical Need?" followed by discussion.

Shared knowledge with translational research practitioners
Year(s) Of Engagement Activity 2014
URL http://translate-event.charite.de/?page_id=2
 
Description UCL Division of Medicine Speaker Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This symposium was excellent and was attended by a good, multidisciplinary audience. I was able to re-connect with several local collaborators and discuss project ideas.
Year(s) Of Engagement Activity 2016
 
Description UKRMP Commercialisation Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Dragon's Den Commercialisation Workshop. UKRMP researchers pitched ideas for products and services and received feedback from a panel of industry experts with constructive criticism allowing them to further develop research ideas.
Year(s) Of Engagement Activity 2017
 
Description Warrington Literary Society: Stem Cells and Therapy lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk with long discusison about diferent kinds of stem cells and their use in medicine

Better informed lay group
Year(s) Of Engagement Activity 2014
 
Description What is Regenerative Medicine? 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Lay type presentation explaining what the opportunities are in the sector with exemplar talks form PhD students postdoctoral researchers and research fellows
Year(s) Of Engagement Activity 2017
 
Description What is Regenerative Medicine? 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact A workshop to inform Undergraduates about what regenerative medicine is and how t can expand the possibiites for Medicine ( based on our successful workshop in 2017)
Year(s) Of Engagement Activity 2018
 
Description Women in Science Becoming the Best 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dissemaination of information advice and support for women's role and leadership in scince
Year(s) Of Engagement Activity 2016