Centre for Cognitive Ageing & Cognitive Epidemiology
Lead Research Organisation:
University of Edinburgh
Department Name: Centre Cogn Ageing and Cogn Epidemiology
Abstract
In 2008 we formed the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) at the University of Edinburgh. This brought together a diverse range of scientists-epidemiologists, psychologists, geriatricians, clinical and basic neuroscientists, geneticists, statisticians, sociologists-to study how the brain and the body influence each other across the human life course and between generations. This application describes how CCACE enhanced this important research, and our plans for the next five years.
The Centre brought a step change in our scientific achievements, our training of young scientists, and the communication of our research to wider, non-scientific groups. In science, we made achievements in four areas. (1) Our discoveries made us the leading international centre for the study of how intelligence from youth influences physical health, wellbeing, mental illness and mortality later in life (cognitive epidemiology). (2) In our large groups of older people on whom there were measures of intelligence from youth we made discoveries about genetic, lifestyle, brain structure and other contributions to the ageing of thinking (cognitive) skills that put us at the forefront internationally. Our discoveries on how diabetes affects thinking skills are based on one of the largest studies. (3) Our work uses theories of how the brain works to explore ageing effects on important specific thinking skills. This led to our devising tests for the early detection of dementia. (4) Our scientists working on the biological mechanisms of cognitive decline have made discoveries in human and animal studies that revealed likely biological routes for the amelioration of cognitive ageing. The Centre's presence brought new collaborators, gave us the capability to lead new cohorts and international consortia, and brought in a new Alzheimer Research Centre.
The Centre brought a step change in the training of young scientists. The thriving mix of successful scientists working together has built up a community of PhD students concentrating on our aims. Many who are not funded by the Centre have come under our umbrella, adding value. We are meeting a need for the training of clinical scientists in our areas. The Centre has also been responsible for a step change in knowledge exchange. Our work with lay people, policy makers, artists, and business has brought our science out of the office and laboratory, creating awareness, new art, and products, and influencing policy.
In the next five years the University of Edinburgh is generously supporting the Centre by funding a substantial amount of what originally came from LLHW funding. In research training, our vision is to mentor young scientists from the end of their PhDs and helpi them to develop into independent scientists in cognitive ageing and cognitive epidemiology to meet these important needs. In our four research Groups' fields we highlight the key areas in which we aim to make discoveries. Here, we mention a few. We are expanding our cognitive epidemiology work to examine how personality and thinking skills affect later health and illness. We shall conduct large-scale new genetic work in our cohorts of older people to find out how people's environments affect how their genes switch on and off and thereby affect thinking skills and other aspects of ageing. We shall conduct unusually large longitudinal studies to examine the parallel changes in brain scans and thinking skills, and the changes in cognition over 10 years in people with type 2 diabetes. We shall delve into specific thinking processes to find the precise sets of problems that best characterise various forms of normal and illness-based cognitive ageing. We shall undertake parallel human and animal work to investigate the importance and nature of changes in small blood vessels for brain health and thinking skills. We have an ambitious strategy for an expanded and more formalised programme of knowledge exchange.
The Centre brought a step change in our scientific achievements, our training of young scientists, and the communication of our research to wider, non-scientific groups. In science, we made achievements in four areas. (1) Our discoveries made us the leading international centre for the study of how intelligence from youth influences physical health, wellbeing, mental illness and mortality later in life (cognitive epidemiology). (2) In our large groups of older people on whom there were measures of intelligence from youth we made discoveries about genetic, lifestyle, brain structure and other contributions to the ageing of thinking (cognitive) skills that put us at the forefront internationally. Our discoveries on how diabetes affects thinking skills are based on one of the largest studies. (3) Our work uses theories of how the brain works to explore ageing effects on important specific thinking skills. This led to our devising tests for the early detection of dementia. (4) Our scientists working on the biological mechanisms of cognitive decline have made discoveries in human and animal studies that revealed likely biological routes for the amelioration of cognitive ageing. The Centre's presence brought new collaborators, gave us the capability to lead new cohorts and international consortia, and brought in a new Alzheimer Research Centre.
The Centre brought a step change in the training of young scientists. The thriving mix of successful scientists working together has built up a community of PhD students concentrating on our aims. Many who are not funded by the Centre have come under our umbrella, adding value. We are meeting a need for the training of clinical scientists in our areas. The Centre has also been responsible for a step change in knowledge exchange. Our work with lay people, policy makers, artists, and business has brought our science out of the office and laboratory, creating awareness, new art, and products, and influencing policy.
In the next five years the University of Edinburgh is generously supporting the Centre by funding a substantial amount of what originally came from LLHW funding. In research training, our vision is to mentor young scientists from the end of their PhDs and helpi them to develop into independent scientists in cognitive ageing and cognitive epidemiology to meet these important needs. In our four research Groups' fields we highlight the key areas in which we aim to make discoveries. Here, we mention a few. We are expanding our cognitive epidemiology work to examine how personality and thinking skills affect later health and illness. We shall conduct large-scale new genetic work in our cohorts of older people to find out how people's environments affect how their genes switch on and off and thereby affect thinking skills and other aspects of ageing. We shall conduct unusually large longitudinal studies to examine the parallel changes in brain scans and thinking skills, and the changes in cognition over 10 years in people with type 2 diabetes. We shall delve into specific thinking processes to find the precise sets of problems that best characterise various forms of normal and illness-based cognitive ageing. We shall undertake parallel human and animal work to investigate the importance and nature of changes in small blood vessels for brain health and thinking skills. We have an ambitious strategy for an expanded and more formalised programme of knowledge exchange.
Technical Summary
The Centre will: (1) elucidate the routes to the vulnerable ageing brain; (2) find mechanisms by which lower cognitive ability makes the body vulnerable to ill health; (3) provide an outstanding environment for interdisciplinary research training.
In research training:
Mentor a new cohort of post-doctoral scientists.
Expand our cohort of interdisciplinary PhD students.
Expand our training of medical scientists.
In cognitive epidemiology:
Expand it to include non-cognitive traits.
Conduct individual participant meta-analyses.
Use new datasets to test mechanistic hypotheses.
In cohort work on cognitive ageing:
Expand work on the Lothian Birth Cohorts and Edinburgh type 2 Diabetes Study.
Test genetic and environmental influences on cognitive change from childhood to old age and in old age.
Test determinants of cognitive change across 10 years in type 2 diabetes.
Conduct longitudinal genome-wide methylation studies.
Conduct genome-wide expression studies.
Test associations between the human brain connectome and cognitive functions.
Lead international consortia on GWAS, exome chip, and methylation studies of cognition, novel brain imaging and other phenotypes.
In experimental work on cognitive ageing:
Complete regulatory approval for Alzheimer diagnostic tests.
Use brain imaging to explore why some cognitive functions are preserved with age.
Identify cognitive signatures that identify those likely to convert to dementia.
Explore the relationship between the design and use of digital memory systems and our research on age-impaired forgetting and multitasking.
In mechanisms of cognitive ageing:
Investigate how stress and glucocorticoids influence cognitive ageing and test therapeutic strategies.
In cerebral small vessel disease test the importance of vascular integrity, inflammation and oxidative stress for ageing brain integrity.
Understand how brain injury occurring in the context of acute systemic illness can alter cognitive decline.
In research training:
Mentor a new cohort of post-doctoral scientists.
Expand our cohort of interdisciplinary PhD students.
Expand our training of medical scientists.
In cognitive epidemiology:
Expand it to include non-cognitive traits.
Conduct individual participant meta-analyses.
Use new datasets to test mechanistic hypotheses.
In cohort work on cognitive ageing:
Expand work on the Lothian Birth Cohorts and Edinburgh type 2 Diabetes Study.
Test genetic and environmental influences on cognitive change from childhood to old age and in old age.
Test determinants of cognitive change across 10 years in type 2 diabetes.
Conduct longitudinal genome-wide methylation studies.
Conduct genome-wide expression studies.
Test associations between the human brain connectome and cognitive functions.
Lead international consortia on GWAS, exome chip, and methylation studies of cognition, novel brain imaging and other phenotypes.
In experimental work on cognitive ageing:
Complete regulatory approval for Alzheimer diagnostic tests.
Use brain imaging to explore why some cognitive functions are preserved with age.
Identify cognitive signatures that identify those likely to convert to dementia.
Explore the relationship between the design and use of digital memory systems and our research on age-impaired forgetting and multitasking.
In mechanisms of cognitive ageing:
Investigate how stress and glucocorticoids influence cognitive ageing and test therapeutic strategies.
In cerebral small vessel disease test the importance of vascular integrity, inflammation and oxidative stress for ageing brain integrity.
Understand how brain injury occurring in the context of acute systemic illness can alter cognitive decline.
Planned Impact
We described above that a wide range of academics benefit from our research. Our research on the determinants of cognitive ageing and the factors that promote bodily health through life are of very wide public and professional interest. The non-academic beneficiaries of this work will be older people, care providers, the wider general public, public health providers, policy makers, third sector organisations, and business. Of those organisations mentioned in the guidance notes, our work already appears in Science Museums in London and Glasgow and we are in regular contact with the charity Age Uk with whom we have a joint Knowledge Exchange programme.
Our research, coupled with our knowledge exchange strategy, will enable older people to understand what happens to cognitive abilities with increasing age, learn which potentially preventable factors affect brain health and cognitive function, benefit from more accurate diagnosis of Alzheimer's disease or delirium, and, for example, from information about ways to compensate for some of the effects of dementia by not undertaking certain forms of dual tasking. Our research will also benefit those who care for people with dementia; for instance, advice about the difficulties such patients have with carrying out more than one mental task simultaneously.
As regards public health providers, our research has the potential to lead to interventions to ameliorate age-related cognitive decline and provide clinical benefits through the development of methods for more accurate diagnosis of dementia or delirium. For third sector organisations, our research will provide benefits in terms of the advice and support they can offer to older people who are concerned about cognitive ageing and brain health. We have already provided this to Age UK for its widely-distributed book on Ageing Well.
CCACE members and core staff have a strong track record of engagement with policy makers. Our research will provide benefits to policy audiences at a national (UK and Scottish) government level and also NHS and local councils. This has and will continue to be in the form of research evidence about the effects of cognitive ageing, the importance of maintaining brain health, the life-long nature of ageing, earlier and accurate diagnosis of dementia (or otherwise), and ways in which cognitive decline might be ameliorated or delayed-all of crucial importance at a time of rapid population ageing. The commercial sector will benefit from our research because it involves the development of diagnostic tools as well as, for instance, guidelines for the care of individuals by private care organisations. All these beneficiaries are likely to benefit from our research within 1 to 5 years.
Our work with artists has benefited both that community and also the people who have come to see the science-art projects we have engaged in. Artist Linda Fleming produced an exhibition (shown at InSpace in Edinburgh and Hancock Gallery in Newcastle) that explored the association between cognitive and bodily health in the Lothian Birth Cohort 1936. We currently have renowned portrait artist Fionna Carlisle creating portraits of scientists and participants in our ageing cohorts to explore ageing. We have writer Ann Lingard creating life narratives of the scientists and participants of our Lothian Birth Cohorts. We have hosted and created three theatre productions to explore cognitive ageing. We have two grant applications in for more science-art projects. We plan more high-quality artistic joint projects to achieve awareness of our research issues.
For staff and research students working in the Centre, we ensure that they have multidisciplinary training. This makes them especially well prepared for an independent research career. They benefit from working in an area of such growing public importance, and in a Centre which works hard to create the best and widest awareness and understanding of our research.
Our research, coupled with our knowledge exchange strategy, will enable older people to understand what happens to cognitive abilities with increasing age, learn which potentially preventable factors affect brain health and cognitive function, benefit from more accurate diagnosis of Alzheimer's disease or delirium, and, for example, from information about ways to compensate for some of the effects of dementia by not undertaking certain forms of dual tasking. Our research will also benefit those who care for people with dementia; for instance, advice about the difficulties such patients have with carrying out more than one mental task simultaneously.
As regards public health providers, our research has the potential to lead to interventions to ameliorate age-related cognitive decline and provide clinical benefits through the development of methods for more accurate diagnosis of dementia or delirium. For third sector organisations, our research will provide benefits in terms of the advice and support they can offer to older people who are concerned about cognitive ageing and brain health. We have already provided this to Age UK for its widely-distributed book on Ageing Well.
CCACE members and core staff have a strong track record of engagement with policy makers. Our research will provide benefits to policy audiences at a national (UK and Scottish) government level and also NHS and local councils. This has and will continue to be in the form of research evidence about the effects of cognitive ageing, the importance of maintaining brain health, the life-long nature of ageing, earlier and accurate diagnosis of dementia (or otherwise), and ways in which cognitive decline might be ameliorated or delayed-all of crucial importance at a time of rapid population ageing. The commercial sector will benefit from our research because it involves the development of diagnostic tools as well as, for instance, guidelines for the care of individuals by private care organisations. All these beneficiaries are likely to benefit from our research within 1 to 5 years.
Our work with artists has benefited both that community and also the people who have come to see the science-art projects we have engaged in. Artist Linda Fleming produced an exhibition (shown at InSpace in Edinburgh and Hancock Gallery in Newcastle) that explored the association between cognitive and bodily health in the Lothian Birth Cohort 1936. We currently have renowned portrait artist Fionna Carlisle creating portraits of scientists and participants in our ageing cohorts to explore ageing. We have writer Ann Lingard creating life narratives of the scientists and participants of our Lothian Birth Cohorts. We have hosted and created three theatre productions to explore cognitive ageing. We have two grant applications in for more science-art projects. We plan more high-quality artistic joint projects to achieve awareness of our research issues.
For staff and research students working in the Centre, we ensure that they have multidisciplinary training. This makes them especially well prepared for an independent research career. They benefit from working in an area of such growing public importance, and in a Centre which works hard to create the best and widest awareness and understanding of our research.
Organisations
- University of Edinburgh (Lead Research Organisation)
- University of Glasgow (Collaboration)
- Lille University Hospital (Collaboration)
- University of Zurich (Collaboration)
- Technical University of Munich (Collaboration)
- Karolinska Institute (Collaboration)
- Social Enterprise UK (Collaboration)
- Rush University (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Paris Diderot University (Collaboration)
- National Records of Scotland (Collaboration)
- Oregon Health and Science University (Collaboration)
- Cardiff University (Collaboration)
- The National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge (Collaboration)
- Heriot-Watt University (Collaboration)
- Johns Hopkins University (Collaboration)
- Osaka University (Collaboration)
- Government of Scotland (Collaboration)
- Columbia University (Collaboration)
- NHS Blood and Transplant (NHSBT) (Collaboration)
- Fondazione IRCCS Istituto Nazionale dei Tumori (Collaboration)
- University of Bristol (Collaboration)
- University of Talca (Collaboration)
- University College London (Collaboration)
- Health Statistics Unit (Collaboration)
- University of California, Riverside (Collaboration)
- Cayetano Heredia University (Collaboration)
- Newcastle University (Collaboration)
- Korea Advanced Institute of Science and Technology (KAIST) (Collaboration)
- Auckland University of Technology (AUT) (Collaboration)
- Hokkaido University (Collaboration)
- MaGIC (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- Lagos State University (Collaboration)
- University of Tokyo (Collaboration)
- University of Texas at Austin (Collaboration)
- Del Rosario University (Collaboration)
- Medical University of Graz (Collaboration)
- Free University of Amsterdam (Collaboration)
- Johnson & Johnson (Collaboration)
Publications
A Gadd D
(2021)
The genetic and epigenetic profile of serum S100ß in the Lothian Birth Cohort 1936 and its relationship to Alzheimer's disease.
in Wellcome open research
A Gadd D
(2021)
The genetic and epigenetic profile of serum S100ß in the Lothian Birth Cohort 1936 and its relationship to Alzheimer's disease
in Wellcome Open Research
Abdulrahman H
(2017)
Dopamine and memory dedifferentiation in aging
in NeuroImage
Abrahams S
(2014)
Screening for cognition and behaviour changes in ALS.
in Amyotrophic lateral sclerosis & frontotemporal degeneration
Abrahams S
(2013)
Executive dysfunction in ALS is not the whole story.
in Journal of neurology, neurosurgery, and psychiatry
Adams HH
(2016)
Novel genetic loci underlying human intracranial volume identified through genome-wide association.
in Nature neuroscience
Adams MJ
(2020)
Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.
in International journal of epidemiology
Adams MJ
(2020)
Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition.
in Psychological medicine
| Title | Additional file 1: Figure S1. of Associations among height, body mass index and intelligence from age 11 to age 78 years |
| Description | Height, body mass index and intelligence at age 11 years by sub-sample. MHT IQ = Moray House Test intelligence quotient; BMI = body mass index. Correlations between height (top/blue) and BMI (bottom/red), and IQ at age 11 are represented for members of the 36-Day Sample who participated in the Scottish Mental Survey of 1947 (N = 5,742), for those who also provided physical measurements in older age (N = 392) and those who also completed cognitive testing (N = 343). (TIF 547 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2016 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Associations_amon... |
| Title | Additional file 1: Figure S1. of Associations among height, body mass index and intelligence from age 11 to age 78 years |
| Description | Height, body mass index and intelligence at age 11 years by sub-sample. MHT IQ = Moray House Test intelligence quotient; BMI = body mass index. Correlations between height (top/blue) and BMI (bottom/red), and IQ at age 11 are represented for members of the 36-Day Sample who participated in the Scottish Mental Survey of 1947 (N = 5,742), for those who also provided physical measurements in older age (N = 392) and those who also completed cognitive testing (N = 343). (TIF 547 kb) |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2016 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Associations_amon... |
| Title | Additional file 2 of Memory markers in the continuum of the Alzheimer's clinical syndrome |
| Description | Additional file 2: Supplementary Figure 1. Example trial of the Perceptual Binding Task used for screening purposes (A) and both conditions of the VSTMB task (B). See text in the manuscript (Method) for a full description of these tasks. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_2_of_Memory_markers_in_the_conti... |
| Title | Additional file 2 of Memory markers in the continuum of the Alzheimer's clinical syndrome |
| Description | Additional file 2: Supplementary Figure 1. Example trial of the Perceptual Binding Task used for screening purposes (A) and both conditions of the VSTMB task (B). See text in the manuscript (Method) for a full description of these tasks. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/figure/Additional_file_2_of_Memory_markers_in_the_conti... |
| Title | Brain Box |
| Description | Brain Box is a portable workshop/festival resource to excite children and adults about the brain, how it works and the changes it goes through in a lifetime. It is a resource for guided workshops, festivals, exhibitions and events that would over time develop an online "personality" tweeting about its day with photo's, comments and quotes: see me on Twitter @brainboxone |
| Type Of Art | Artefact (including digital) |
| Year Produced | 2014 |
| Impact | To date, the Brain Box has received funding from the MRC Regional Communications Fund and, despite still being at the development stage, is planned to appear at workshops as part of the Edinburgh International Science Festival 14-18 April 2015. |
| URL | http://www.twitter.com/brainboxone |
| Title | Brain Training on Trial |
| Description | An hour-long show developed for the Edinburgh Festival Fringe 2014, involving audience participation and presentation of research on the usefulness of brain training. The show took the form of a 'trial' in which the audience was the jury and co-presenter the judge. |
| Type Of Art | Performance (Music, Dance, Drama, etc) |
| Year Produced | 2014 |
| Impact | The trailer for the show was uploaded to You Tube and has been viewed 534 times as at 7th November 2014 (http://www.youtube.com/watch?feature=player_embedded&v=9g2puKGaE-E). The post-event summing up video has also been uploaded to You Tube on 20th October 2014 and has been viewed 70 times (http://www.youtube.com/watch?v=fROGW49Z81Q). A blog post was also written summarising the evidence for and against brain training. |
| URL | http://researchtheheadlines.org/2014/09/09/brain-training-on-trial/ |
| Title | Fashion design final year show - Russ |
| Description | This CCACE member met with a fourth year student at Heriot Watt University studying Fashion Design who chose to base her final collection design concept around dementia. They discussed the science of dementia and its investigation. She subsequently developed the designs into scarves which she sold in aid of Alzheimer Scotland. |
| Type Of Art | Artefact (including digital) |
| Year Produced | 2016 |
| Impact | The design student developed the designs into scarves which she sold in aid of Alzheimer Scotland. She is now developing the designs for a range with the high street retailer H&M. |
| URL | https://www.nadiapinkney.com/remember-me-knot |
| Title | LBC1936 Fast Facts Card |
| Description | Dr Simon Cox and Professor Ian Deary designed a 'Lothian Birth Cohort 1936 Fast Facts Card' - a 12 facet credit-card sized concertina leaflet containing information about the LBC1936 study for distribution to the general public at future KE events, interested academics / potential collaborators, LBC members etc. |
| Type Of Art | Artefact (including digital) |
| Year Produced | 2014 |
| Impact | This has been distributed to interested academics and potential collaborators and will be distributed to participants in the Lothian Birth Cohort 1936. Age Scotland have requested 150 and an initial print run consisted of 2000 copies. |
| Title | Lifetimes book - Ann Lingard |
| Description | CCACE collaborated with a local author, Ann Lingard, to create a short book entitled 'Lifetimes - personal stories from the Lothian Birth Cohorts'. Ann interviewed several participants in both Lothian Birth Cohorts 1921 and 1936 and several members of staff, including the Centre director, creating this short collection of life stories. It has been professionally typeset with an attractive cover and introduction by CCACE/LBC director Ian Deary. It is heavily illustrated with photographs reflecting the life courses of the participants and scientists in the Lothian Birth Cohort studies. |
| Type Of Art | Creative Writing |
| Year Produced | 2014 |
| Impact | The book has been sent to all CCACE collaborators and contacts, as well as being given out to participants at the Lothian Birth Cohort reunion in April 2014. It has been available to download as an e-book on various websites for many months. About 2000 physical copies of the book have been printed. It is free on iTunes, and there is a nominal cost (77p) on Amazon for a Kindle edition. |
| URL | https://itunes.apple.com/gb/book/lifetimes/id893954634?mt=11 |
| Title | MOESM7 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 7: Figure S1. Proteomics workflow. Samples were prepared from postmortem tissue and processed for proteomics analysis according to the workflow shown. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2019 |
| URL | https://springernature.figshare.com/articles/MOESM7_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM7 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 7: Figure S1. Proteomics workflow. Samples were prepared from postmortem tissue and processed for proteomics analysis according to the workflow shown. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2019 |
| URL | https://springernature.figshare.com/articles/MOESM7_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM8 of Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype |
| Description | Additional file 8: Figure S2. Protein degradation blot example. Protein degradation blots were completed for all samples using NMDA NR2B antibody (a). The ratio of band 1, which is found in vivo, to band 2, which appears with postmoretem degradation was calculated (b) and samples with a ratio |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2019 |
| URL | https://springernature.figshare.com/articles/MOESM8_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM8 of Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype |
| Description | Additional file 8: Figure S2. Protein degradation blot example. Protein degradation blots were completed for all samples using NMDA NR2B antibody (a). The ratio of band 1, which is found in vivo, to band 2, which appears with postmoretem degradation was calculated (b) and samples with a ratio |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2019 |
| URL | https://springernature.figshare.com/articles/MOESM8_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM9 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 9: Figure S3. Validation western blots. Validation western blots (uncropped) of AD vs non demented control (NDC) from BA41/42 of people with APOE3/4 genotype. Full blots are shown for PSD95 and alpha-synuclein (a), SOD2 (b), annexin V (c), TMEM97 (d), beta tubulin (e), and total protein at high intensity (f) and low intensity (g). Each of the molecular weight ranges in g were quantified for each lane, shown in (h). Comparisons between proteomics and western blot data are shown in i. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2019 |
| URL | https://springernature.figshare.com/articles/MOESM9_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM9 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 9: Figure S3. Validation western blots. Validation western blots (uncropped) of AD vs non demented control (NDC) from BA41/42 of people with APOE3/4 genotype. Full blots are shown for PSD95 and alpha-synuclein (a), SOD2 (b), annexin V (c), TMEM97 (d), beta tubulin (e), and total protein at high intensity (f) and low intensity (g). Each of the molecular weight ranges in g were quantified for each lane, shown in (h). Comparisons between proteomics and western blot data are shown in i. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2019 |
| URL | https://springernature.figshare.com/articles/MOESM9_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | Portraits - Fionna Carlisle |
| Description | CCACE has been collaborating with a local artist, Fionna Carlisle, who has painted portraits of the Centre director, Ian Deary, several of the Centre's staff, and a number of participants from the Lothian Birth Cohort studies. She is aiming to complete a collection of over 20 portraits of participants and scientists. |
| Type Of Art | Artwork |
| Year Produced | 2014 |
| Impact | The artwork has been displayed at a number of prestigious local and national events, including as part of an exhibition at the British Library in London entitled Portraying Ageing on 28th April 2014, and at local events associated with the MRC Centenary. The CCACE knowledge exchange officer and Fionna Carlisle, along with Centre director Ian Deary, are in discussion with local art galleries and museums with regard to a full-scale exhibition of these portraits and the scientific programme of work which lies behind them. |
| URL | http://www.fionnacarlisle.com/ |
| Title | The Art of Intelligent Ageing exhibition |
| Description | In 2012, artist Fionna Carlisle, began work on a series of portraits of Lothian Birth Cohorts participants and research team members. In October 2018, The Art of Intelligent Ageing exhibition showcased the completed series and featured interesting artifacts from the Lothian Birth Cohorts. |
| Type Of Art | Artistic/Creative Exhibition |
| Year Produced | 2018 |
| Impact | 599 people attended the exhibition and it was covered by various media outlets including STV evening news and the Scotsman. |
| URL | https://www.scotsman.com/lifestyle/culture/art/art-reviews-the-art-of-intelligent-ageing-andrew-cran... |
| Title | The Great British Brain Off - Alan Gow |
| Description | The Great British Brain Off. Show at the Edinburgh Festival Fringe as part of Edinburgh Beltane's Cabaret of Dangerous Ideas, Edinburgh, UK, 27th August 2015. Performance, associated trailer, and follow-up video: https://www.youtube.com/watch?v=X20p9oCYI8Y https://www.youtube.com/watch?v=yZF76K1hKDk |
| Type Of Art | Performance (Music, Dance, Drama, etc) |
| Year Produced | 2015 |
| Impact | Raise the profile of cognitive ageing research. |
| Title | The Living Brain short film - Anne Milne |
| Description | CCACE collaborated with film maker Anne Milne to produce a short film describing the Lothian Birth Cohort 1921 and 1936 studies and charting the life course and current circumstances of one participant from each study. The film was premiered at the Lothian Birth Cohort reunion in April 2014 and has since been screened a number of times, including at the CCACE Annual Research Day in August 2014 and Midlothian Science Festival in October 2014. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2014 |
| Impact | The film has been screened a number of times, both to research participants, collaborators and other academics, and members of the public attending a science festival talk. It has now been seen by, we estimate, many hundreds of people and Anne Milne has plans to submit it to film festivals and science festivals. The film is listed on www.imdb.com. |
| URL | http://www.imdb.com/name/nm3596775/ |
| Description | ALLEA UK representative - Pickersgill |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | http://www.allea.org/Pages/ALL/4/731.bGFuZz1FTkc.html |
| Description | Age UK/AARP Global Council on Brain Health expert meeting (Gow) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Impact | The Global Council on Brain Health convenes experts who then produce reports on factors affecting cognitive and brain function. These are widely distributed so that people's knowledge and actions (e.g. lifestyle changes) are based upon the best available empirical evidence. This is done in part via Age UK, the largest UK ageing charity with a very wide reach to older people in the UK and internationally. |
| URL | http://www.ageuk.org.uk/professional-resources-home/research/about-age-uk-research/the-global-counci... |
| Description | Assigned Chair of SIGN Guidelines Committee on delirium - MacLullich |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| URL | http://www.sign.ac.uk/pdf/Delirium_KQs_v0%203_consultation.pdf |
| Description | BBSRC Bioscience for Society Strategy Panel - Pickersgill |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Citation in a Report of the Surgeon General on Smoking Cessation |
| Geographic Reach | North America |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.ncbi.nlm.nih.gov/books/NBK555591/ |
| Description | Citation in a report by the AARP's Global Council on Brain Health |
| Geographic Reach | North America |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.aarp.org/content/dam/aarp/health/brain_health/2020/02/gcbh-heart-health-report-english.d... |
| Description | Citation in the House of Lords report on Ageing: Science, Technology and Healthy Living |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://publications.parliament.uk/pa/ld5801/ldselect/ldsctech/183/183.pdf |
| Description | Citizens Jury report on Guthrie spots - David Porteous |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | European Commission, Directorate General Education and Culture, Thematic Panel on Languages & Literacy |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Informed the Government on educational changes. |
| Description | Global Council on Brain Health - Alan Gow |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Global Council on Brain Health (2017). "The Brain and Social Connectedness: GCBH Recommendations on Social Engagement and Brain Health." |
| URL | http://www.GlobalCouncilOnBrainHealth.org |
| Description | Global young leader in dementia - Russ |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | I was recommended by the MRC and selected as one of Europe's young leaders in dementia by the World Dementia Council. I attended the European event in London to identify innovative ideas to address dementia following the G8 Summit & World Council on Dementia. The priorities for dementia research and care which the global young leaders drafted at a number of international meetings were presented to the World Council on Dementia in 2015. |
| URL | http://www.neurodegenerationresearch.eu/2015/03/young-leaders-from-across-europe-join-global-search-... |
| Description | Influencing national health indicator - Russ |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | My work on psychological distress (e.g. Russ et al., 2012) has been used to recommend the introduction of a new indicator by the Department of Health: "Excess under 75 mortality rate in adults with common mental illness" (Indicator 1.5 ii in the NHS Outcomes Framework 2015/16). |
| URL | http://www.gov.uk/government/publications/nhs-outcomes-framework-2015-to-2016 |
| Description | MRC review of UK population studies - LBC |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | http://www.mrc.ac.uk/news-events/publications/maximising-the-value-of-uk-population-cohorts/ |
| Description | Northern Ireland Department for Communities, Irish Language Academy, Belfast |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Informed the public of educational changes. |
| Description | Report for the Federation of European Academies of Medicine (FEAM) and All European Academies of Science (ALLEA) - David Hill |
| Geographic Reach | Europe |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://www.allea.org/wp-content/uploads/2018/11/Health_Inequalities_Symposium_Report.pdf. |
| Description | Review of cognitive ageing and financial services |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| URL | https://www.fca.org.uk/publication/research/ageing-mind-literature.pdf |
| Description | SAPEA report "Transforming the Future of Ageing" - Alan Gow |
| Geographic Reach | Europe |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://ec.europa.eu/research/sam/index.cfm?pg=ageing |
| Description | Science and Trust Parliamentary Links Day - Pickersgill |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Scottish Government Data Linkage Framework - Deary |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Scottish Public Health Network (Johnson) |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | ADRC - Scotland, ESRC |
| Amount | £7,930,752 (GBP) |
| Funding ID | ES/L007487/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2013 |
| End | 10/2018 |
| Description | AHRC-OWRI Multilingualism: Empowering Individuals, Transforming Societies (MEITS) |
| Amount | £419,496 (GBP) |
| Funding ID | AH/N004671/1 |
| Organisation | Arts & Humanities Research Council (AHRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 06/2020 |
| Description | Advancing Care and treatment of Vascular Dementia (Stroke Association/BHF/Alzheimer's Society) |
| Amount | £800,000 (GBP) |
| Organisation | Stroke Association |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Age UK - The Disconnected Mind, Phase 3 |
| Amount | £1,317,193 (GBP) |
| Organisation | Age UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2019 |
| Description | Alzheimer Scotland Dementia Reseach Centre renewal funding (CCACE sister Centre) - John Starr |
| Amount | £750,000 (GBP) |
| Organisation | Alzheimer Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Alzheimer Scotland: Marjorie MacBeath bequest - Russ |
| Amount | £100,000 (GBP) |
| Funding ID | R44120 |
| Organisation | Alzheimer Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 08/2016 |
| Description | Alzheimer's Research UK Major Project Grant |
| Amount | £166,833 (GBP) |
| Funding ID | ARUK-PG2017B-10 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2020 |
| Description | Alzheimer's Research UK senior research fellowship |
| Amount | £420,000 (GBP) |
| Funding ID | ARUK-SRF2018B-009 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 06/2023 |
| Description | Alzheimer's Society - Fergus Doubal |
| Amount | £245,385 (GBP) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2017 |
| Description | Augmented Reality Brain. Medical Research Council Public Engagement in Science Activities Seed Fund |
| Amount | £1,500 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 07/2019 |
| Description | Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: IV |
| Amount | £596,355 (GBP) |
| Funding ID | MR/R024065/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 04/2021 |
| Description | British Academy - Alan Gow |
| Amount | £14,939 (GBP) |
| Organisation | The British Academy |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2016 |
| Description | CSO Cerebrovascular reactivity - Wardlaw Doubal Marshall |
| Amount | £137,420 (GBP) |
| Organisation | Chief Scientist Office |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2014 |
| End | 07/2015 |
| Description | Chest Heart Stroke Scotland - Wardlaw |
| Amount | £75,815 (GBP) |
| Organisation | Chest Heart & Stroke Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2014 |
| End | 01/2016 |
| Description | Clinical Fellowship - Russ |
| Amount | £100,000 (GBP) |
| Funding ID | R44120 |
| Organisation | Alzheimer Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 08/2016 |
| Description | Colciencias, Colombia. Emergent Social and Health Challenges |
| Amount | £16,000 (GBP) |
| Organisation | Administrative Department of Science, Technology and Innovation (Colciencias) |
| Sector | Public |
| Country | Colombia |
| Start | 06/2016 |
| End | 12/2016 |
| Description | Conference travel funding - Alan Gow |
| Amount | £950 (GBP) |
| Organisation | Royal Society of Edinburgh (RSE) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 04/2016 |
| Description | Confidence in Global Mental Health Research 2017 |
| Amount | £188,567 (GBP) |
| Funding ID | MR/R01910X/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 02/2019 |
| Description | Doctoral Training Programme - Karen Horsburgh |
| Amount | £346,000 (GBP) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2015 |
| End | 08/2018 |
| Description | Dunhill Medical Trust - Alan Gow |
| Amount | £74,700 (GBP) |
| Funding ID | R359/0514 |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2014 |
| End | 05/2016 |
| Description | Dunhill Medical Trust - Tablet for Healthy Ageing (Gow) |
| Amount | £74,700 (GBP) |
| Funding ID | R359/0514 |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2014 |
| End | 04/2016 |
| Description | EPSRC Multi-modal retinal biomarkers - Wardlaw Doubal Deary |
| Amount | £1,100,000 (GBP) |
| Funding ID | EP/M005976/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2018 |
| Description | EPSRC: retinal biomarkers |
| Amount | £1,153,990 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2015 |
| End | 01/2018 |
| Description | ESRC Project Grant - Working memory across the adult lifespan: An adversarial collaboration (Logie) |
| Amount | £1,154,370 (GBP) |
| Funding ID | ES/N010728/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 04/2020 |
| Description | ESRC: Epigenetics |
| Amount | £667,456 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 09/2018 |
| Description | EU Joint Programme - neurodegeneration (Wardlaw) |
| Amount | € 47,416 (EUR) |
| Organisation | EU Joint Programme - Neurodegenerative Disease Research (JPND) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2014 |
| End | 03/2015 |
| Description | Edinburgh Lothians Health Foundation BraINS - Shenkin Wardlaw Job |
| Amount | £38,810 (GBP) |
| Organisation | Edinburgh & Lothians Health Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 03/2015 |
| Description | Evaluating Longitudinal Changes in the Human Structural Connectome in Relation to Cognitive Aging |
| Amount | $502,543 (USD) |
| Funding ID | 1R01AG054628-01A1 |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 08/2017 |
| End | 04/2022 |
| Description | FAPESP-HWU Scheme 2016 (Brazil - Heriot-Watt University) |
| Amount | £40,000 (GBP) |
| Organisation | São Paulo Research Foundation (FAPESP) |
| Sector | Public |
| Country | Brazil |
| Start | 07/2016 |
| End | 08/2018 |
| Description | Factors of biological ageing: does it all go together when it goes? |
| Amount | £886,561 (GBP) |
| Funding ID | 221890/Z/20/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2021 |
| End | 04/2026 |
| Description | Gow Hagger-Johnson - Research visitors to Scotland |
| Amount | £300 (GBP) |
| Organisation | Royal Society of Edinburgh (RSE) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 05/2014 |
| Description | Guest Professor programme - Alan Gow |
| Amount | £3,325 (GBP) |
| Organisation | University of Copenhagen |
| Sector | Academic/University |
| Country | Denmark |
| Start | 11/2015 |
| End | 12/2015 |
| Description | Guest professor - Alan Gow 2013 |
| Amount | £22,500 (GBP) |
| Organisation | Nordea Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 04/2013 |
| End | 07/2013 |
| Description | Guest professor - Alan Gow 2014 |
| Amount | £20,000 (GBP) |
| Organisation | Nordea Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 11/2014 |
| End | 12/2014 |
| Description | Harris pilot study award - Generation Scotland |
| Amount | £8,800 (GBP) |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Cognitive Ageing and Cognitive Epidemiology |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 06/2014 |
| Description | Heriot-Watt Principal's Public Engagement Award (Gow) |
| Amount | £1,000 (GBP) |
| Organisation | Heriot-Watt University |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 06/2016 |
| Description | How do peripheral and central vascular markers relate to cognitive decline? - Deary |
| Amount | £91,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2015 |
| End | 01/2017 |
| Description | INTERpreting epigenetic signatires in Studies of Early Life Adversity (interSTELA) - Deary |
| Amount | £199,512 (GBP) |
| Funding ID | ES/N000382/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2015 |
| End | 08/2017 |
| Description | Improving Health with Environmental Data call |
| Amount | £56,519 (GBP) |
| Organisation | Chief Scientist Office |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 08/2018 |
| Description | Junior Investigator Pilot Award - Zoe Tieges |
| Amount | $49,871 (USD) |
| Organisation | Nidus Partners LP |
| Sector | Private |
| Country | United States |
| Start | 03/2018 |
| End | 10/2018 |
| Description | LACunar Intervention Trial - Fergus Doubal |
| Amount | £847,771 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 02/2019 |
| Description | Leverhulme Trust Research Grant |
| Amount | £106,031 (GBP) |
| Funding ID | RPG-2013-066 |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2013 |
| End | 10/2015 |
| Description | Lifecourse of place: how environments throughout life can support healthy ageing |
| Amount | £287,833 (GBP) |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 05/2022 |
| Description | MRC Confidence in Global Mental Health Research Grant |
| Amount | £196,755 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2019 |
| Description | MRC DTP Precision Medicine PhD - Susan Shenkin |
| Amount | £86,780 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Festival Schools Activity. MRC Festival Open Award |
| Amount | £1,000 (GBP) |
| Funding ID | G29464 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 02/2021 |
| Description | MRC Integrated dementia research environment |
| Amount | £6,825,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2016 |
| Description | MRC Mental Health Data Pathfinder award - Andrew McIntosh, Matthew Iveson |
| Amount | £1,200,000 (GBP) |
| Funding ID | MC_PC_17209 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2020 |
| Description | MRC UK Dementia Platform |
| Amount | £5,639,037 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 03/2019 |
| Description | MRC travel grant - Kathryn Walesby |
| Amount | £1,800 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC: LBC1936 III |
| Amount | £1,316,451 (GBP) |
| Funding ID | MR/M013111/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 02/2019 |
| Description | Moray Endowment Fund (Pickersgill) - animal models and dynamics of biomedicine |
| Amount | £963 (GBP) |
| Organisation | University of Edinburgh |
| Department | Moray Endowment Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2013 |
| Description | NIA - Human structural connectome |
| Amount | $2,384,683 (USD) |
| Funding ID | R01AG054628 |
| Organisation | National Institutes of Health (NIH) |
| Department | National Institute on Aging |
| Sector | Public |
| Country | United States |
| Start | 06/2017 |
| End | 06/2022 |
| Description | Nioi et al Blue light exposure and sleep |
| Amount | £8,164 (GBP) |
| Organisation | Government of Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 12/2014 |
| Description | PhD studentship - Horsburgh |
| Amount | £85,000 (GBP) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 08/2019 |
| Description | PhD studentship - Karen Horsburgh |
| Amount | £99,228 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2015 |
| End | 08/2018 |
| Description | Pickersgill - visiting scholar, Wisconsin-Madison |
| Amount | £932 (GBP) |
| Organisation | Royal Society of Edinburgh (RSE) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 04/2014 |
| Description | Postdoctoral Fellowship |
| Amount | £148,126 (GBP) |
| Funding ID | 316 |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2020 |
| Description | Project grant - Horsburgh |
| Amount | £326,594 (GBP) |
| Organisation | Alzheimer's Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Project grant - Horsburgh |
| Amount | £561,607 (GBP) |
| Funding ID | ARUK-PG2016B-6 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Project grant - JPND (Deary) |
| Amount | £592,325 (GBP) |
| Funding ID | MR/N027558/1 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Human Nutrition Research Group |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 04/2019 |
| Description | Project grant - MacLullich |
| Amount | £260,000 (GBP) |
| Funding ID | ARUK-PG2016B-12 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 10/2018 |
| Description | Project grant - MacLullich |
| Amount | £185,751 (GBP) |
| Funding ID | R484/0516 |
| Organisation | The Dunhill Medical Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 01/2020 |
| Description | Project grant - The Intervention Factory (Gow) |
| Amount | £343,728 (GBP) |
| Organisation | Velux Foundations |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 06/2016 |
| End | 06/2019 |
| Description | Research and Development Grant Scheme (Harrison) |
| Amount | £25,000 (GBP) |
| Funding ID | Ref 854 |
| Organisation | Edinburgh & Lothians Health Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 12/2017 |
| Description | Researcher Links, British Council - Aribisala / Gow |
| Amount | £4,320 (GBP) |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 10/2014 |
| Description | Rewrite the Headlines: Follow-up funding (Gow) |
| Amount | £5,000 (GBP) |
| Organisation | The British Academy |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2017 |
| Description | SFC SINAPSE Network development - Wardlaw et al |
| Amount | £325,000 (GBP) |
| Organisation | Government of Scotland |
| Department | Scottish Funding Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 09/2019 |
| Description | Scottish Government - Alan Gow |
| Amount | £8,164 (GBP) |
| Organisation | Government of Scotland |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 03/2017 |
| Description | Seed fund - Primate Cognition |
| Amount | € 9,657 (EUR) |
| Organisation | Leibniz Association |
| Sector | Academic/University |
| Country | Germany |
| Start | 03/2018 |
| End | 12/2018 |
| Description | Seniors USP - LLHW |
| Amount | £992,001 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Department | Lifelong Health and Wellbeing (LLHW) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 04/2017 |
| Description | Starter grant for clinical lecturers - Russ |
| Amount | £30,000 (GBP) |
| Funding ID | AMS-SGCL12-Russ |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2015 |
| End | 08/2016 |
| Description | Starter grant for clinical lecturers - Russ |
| Amount | £30,000 (GBP) |
| Funding ID | AMS-SGCL12-Russ |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2015 |
| End | 08/2016 |
| Description | Strathclyde University PhD Studentship Research Excellence Award for Health (Gow) |
| Amount | £58,060 (GBP) |
| Organisation | University of Strathclyde |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 08/2020 |
| Description | Stroke Association - Fergus Doubal |
| Amount | £234,989 (GBP) |
| Funding ID | TSA15LECT04 |
| Organisation | Stroke Association |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 05/2020 |
| Description | The Disconnected Mind: Phase 4 |
| Amount | £1,058,650 (GBP) |
| Organisation | Age UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2022 |
| Description | The Intervention Factory: PhD Studentship - Alan Gow |
| Amount | £63,396 (GBP) |
| Organisation | Velux Foundations |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 08/2017 |
| End | 08/2020 |
| Description | The Lothian Birth Cohort 1936 Waves 6 and 7 |
| Amount | £1,620,567 (GBP) |
| Funding ID | BB/W008793/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 08/2025 |
| Description | Translational Neuroscience program - Anna Stevenson |
| Amount | £119,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Translational Neuroscience program - Robert Hillary |
| Amount | £119,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Travel award - Russ |
| Amount | £5,405 (GBP) |
| Organisation | Scottish Universities Life Sciences Alliance |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 08/2016 |
| Description | Travel award - Russ |
| Amount | £1,000 (GBP) |
| Organisation | Alzheimer Scotland |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 08/2016 |
| Description | Travel award - Tieges |
| Amount | £800 (GBP) |
| Organisation | Guarantors of Brain |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 06/2016 |
| Description | Travel grant - Russ |
| Amount | £5,405 (GBP) |
| Organisation | Scottish Universities Life Sciences Alliance |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 08/2016 |
| Description | U01 Research Grant |
| Amount | $155,358 (USD) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | |
| Description | UKRI Strategic Support to Expedite Embedding Public Engagement with Research (SEE-PER) - Phase 2 |
| Amount | £55,263 (GBP) |
| Funding ID | EP/R019835/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2019 |
| Description | UofE Sparking Impact scheme - Shenkin Wardlaw |
| Amount | £19,417 (GBP) |
| Organisation | University of Edinburgh |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 08/2014 |
| Description | WT: MRI |
| Amount | £600,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2019 |
| Description | WT: Stratifying depression |
| Amount | £4,591,695 (GBP) |
| Funding ID | 104036/Z/14/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2020 |
| Description | Wellcome Trust MRI lifecourse influences - Wardlaw |
| Amount | £600,000 (GBP) |
| Funding ID | 106824/Z/15/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2019 |
| Description | Wellcome Trust Multiuser Equipment Grant - Megan Holmes |
| Amount | £1,000,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust STRADL award |
| Amount | £4,750,000 (GBP) |
| Funding ID | 104036/Z/14/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2019 |
| Description | Wellcome Trust Society and Ethics Small Grant |
| Amount | £3,500 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2014 |
| End | 06/2015 |
| Title | 3D brain |
| Description | A 3D Brain based on MRI Scans has been developed. This Brain is true 3D in cyberspace and can be viewed and projected in anaglyph 3D and well as a higher quality rendition using a fast shuttered glasses system from Nvidia. Two Brains are available for viewing at the moment , a healthy young and a healthy old brain. The 3D brain can be rotated and zoomed in real time to allow the demonstration of anatomical features on the reconstructed models. The tools developed are capable of importing any 3D model and future developments may include tractography etc. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2013 |
| Provided To Others? | Yes |
| Impact | This system was used as a demonstrator at the opening of CRIC by HRH Duke of Edinburgh. In 2011 it was demonstrated at the Edinburgh International Science Festival that attracted ~3000 visitors, at the Glasgow Science Centre, and has been taken around schools by CCACE employee Jack Nissan. In 2014 the 3D brain was demonstrated at the Edinburgh Neuroscience Day (March 12th 2014) and at a reception held by Age UK at St James's Palace and hosted by HRH Prince Charles (Jan 28th 2014). |
| Title | CCACE - LBC Lifetimes website |
| Description | The professional writer Ann Lingard composed stories of the lives of members of the Lothian Birth Cohorts of 1921 and 1936 and some of the wscientists working on the research. Each life was "told" as a small online facsimilie book with pictures across the lifecourse of each person. The individual books are professional looking and they have been gathered on to a website. The CCACE Systems Analyst worked closely with the CCACE Knowledge Exchange Officer to develop a new website for a large CCACE arts project called LBC Lifetimes. The project was set up to create stories of the lives and lifetimes of some of the participants and scientists involved in the LBC1936 study. The site has been viewed over 2300 times. |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | The stories are available internationally for those wishing to learn more about the personal backgrounds of participants and esearchers in the Lothian Birth Cohort studies. |
| URL | http://www.lbclifetimes.org |
| Title | Cognitive Estimation Task - MacPherson |
| Description | This is a cognitive test used in the detection of dementia and cognitive ability. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Provided to the Psychology Research Laboratory, IRCCS Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, Italy and an Italian version of the Cognitive Estimation task was devised (Scarpina et al., 2015; Neurological Sciences) |
| URL | https://www.era.lib.ed.ac.uk/handle/1842/8747 |
| Title | Cox - frontal lobe parcellation method |
| Description | Identified and developed a novel method for identifying frontal lobe sub-regions from gyral topography based on a synthesis of previous methods and data from cytoarchitecture and hodology. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | The method was published in Brain Structure and Function (Impact Factor: 7.84) and this paper has been made available with supporting documentation online in the Image Analysis Tool section of the Brain Imaging Research Centre website (http://www.bric.ed.ac.uk/research/imageanalysis.html). Other publications resulted from this method and are published Cortex and Intelligence. |
| Title | Developing a non-invasive cognitive aid to diagnosis and follow up of Alzheimer's Disease - Robert Logie |
| Description | Led by CCACE group leader, Professor Robert Logie and in collaboration with a number of CCACE members a new research tool for diagnosing Alzheimer's Disease has been developed. Over 20 years of laboratory based scientific research, development of prototype software and initial clinical trials has led to a successful collabortion with Toshiba to develop the tool. |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | Collaboration commenced in October 2010. Planned output will be a proven prototype diagnostic aid that may be used in Primary Care and also for evaluation of the effectiveness of interventions in clinical trials. Interest expressed for inclusion in clinical trials of pharmaceutical interventions due to run in 2011. In 2012 the test was adopted by the NHS Medical Devices Unit for Greater Glasgow and Clyde to develop from the current research versions into versions that can be used in routine clinical settings by nurses and General Practitioners. Scottish Health Innovations Ltd. is currently collating the necessary documentation to apply for approval from the UK Medicines and Healthcare products Regulatory Agency for clinical use within the NHS and in healthcare across Europe. |
| Title | Genomic SEM - David Hill |
| Description | In collaboration with the University of Texas at Austin, and the Vrije Universiteit Amsterdam, David Hill was involved in a collaboration that resulted in the method of Genomic SEM being published in Nature Human Behaviour. This tool allows one to jointly analyse the genetic contributions to multiple traits simultaneously. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | N/A. The manuscript describing genomic SEM has been accepted for publication at Nature Human Behaviour and will be available for public use. |
| URL | https://github.com/MichelNivard/GenomicSEM |
| Title | IST-3 trial thrombolysis |
| Description | Joanna Wardlaw has been involved in the third International Stroke Trial (IST-3), a randomised controlled trial of the benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 hours of acute ischaemic stroke. |
| Type Of Material | Model of mechanisms or symptoms - human |
| Provided To Others? | No |
| Impact | Thrombolysis is now widely used in >80's for treatment of acute stroke, thanks to IST-3. |
| Title | Image analysis method - hippocampal shape modelling |
| Description | In collaboration with the Korean Advanced Institute for Science and Technology, we have developed a novel method for hippocampal shape modelling. |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | Cox SR*, Valdés Hernández MC*, Kim J, Royle NA, MacPherson SE, Ferguson KJ, Muñoz Maniega S, Anglaban D, Aribisala BS, Bastin ME, Park J, Starr JM, Deary IJ, MacLullich AJM, Wardlaw JM. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. Psychoneuroendocrinology, doi: 10.1016/j.psyneuen.2017.01.027. Kim J, Valdés Hernández MC, Royle NA, Park J. Hippocampal shape modelling based on a progressive template surface deformation and its verification. IEEE Trans Med Imaging 2015 Jun;34(6):1242-61 Valdés Hernández MC, Cox SR, Kim J, Royle NA, Muñoz Maniega S, Gow AJ, Anglaban D, Bastin ME, Park J, Starr JM, Wardlaw JM, Deary IJ. Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. Neurobiol Aging in press. |
| URL | http://ieeexplore.ieee.org/document/6990617/?reload=true |
| Title | Image analysis methods - IXICO |
| Description | Wardlaw and colleagues have been involved in developing analysis method for older subjects with IXICO, a commercial imaging research group. |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | A Technology Strategy Board grant has been applied for based on pilot work. |
| Title | Liewald - CCACE cluster |
| Description | The CCACE computer cluster has been designed to allow it to deal with large GWAS datasets held by CCACE such as 1000G, exome sequencing and also the Generation Scotland reference genome sets. In conjunction with this are new file handling and merging techniques and pipelines which had to be developed to allow researchers to access and utilise these huge data resources. |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | We have the capability of conducting, securely, large scale genetic analyses for our team and of allowing access to collaborators internationally. |
| Title | New method of perivascular space segmentation on brain MRI |
| Description | MRC-funded imaging team on the LBC1936 developed a new method of perivascular space segmentation, which shows good concordance with neuroradiological assessments. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Ballerini L, Lovreglio R, Valdés Hernández MC, Gonzalez-Castro V, Muñoz Maniega S, Pellegrini E, Bastin ME, Deary IJ, Wardlaw JM. Application of the ordered logit model to optimising Frangi filter parameters for segmentation of perivascular spaces. Procedia Comp Sci 2016 90:61-67. |
| URL | http://www.sciencedirect.com/science/article/pii/S1877050916311899 |
| Title | Observational Scale of Level of Alertness (OSLA) - Roanna Hall |
| Description | CCACE member Dr Roanna Hall developed a new assessment tool for level of alertness in delirium, named the Observational Scale of Level of Alertness (OSLA). It is in the early stages of development, and an abstract assessing its usefulness in assessing alertness in delirium in patients with acute hip fracture was accepted for poster presentation at the European Delirium Association conference in Amsterdam, 11-12 November 2010. A poster on the OSLA was presented at the American Delirium Society inaugural conference in Indianapolis in June 2011 |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | The tool has gained interest from members of conferences, and it has been taken forward for further development. In 2011, Dr Hall and colleagues have been working towards validating and publishing the OSLA. This research tool assesses alertness in hospital inpatients. It fills a gap in the current literature and complements our new cognitive assessment (Edinburgh Delirium Test Boxes 1 and 2). The OSLA has been used several hundred times in our research studies and is being refined with the help of CCACE statistician Dr Mike Allerhand. The refined version of the OSLA is due to be used in new studies in Oslo and Ireland. |
| Title | fastBAT - Hill |
| Description | As part of a collaboration with the University of Queensland we have developed a method, called fastBAT, for combining single nucleotide polymorphism data into a single statistic representing a gene or a group of genes. This allows us to examine the joint effect of multiple genetic variants which can be used as a biomarker for ageing and ageing phenotypes. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Allow data quicker anlaysis. |
| URL | http://cnsgenomics.com/software/gcta/fastBAT.html |
| Title | Additional file 1 of DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936 |
| Description | Additional file 1: Supplementary Tables 1-11. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_1_of_DNA_methylation_outlier_burden_hea... |
| Title | Additional file 1 of DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936 |
| Description | Additional file 1: Supplementary Tables 1-11. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_1_of_DNA_methylation_outlier_burden_hea... |
| Title | Additional file 1: of Epigenetic prediction of complex traits and death |
| Description | DNAm signature CpGs and corresponding weights for BMI (Table S1), smoking (Table S2), alcohol consumption (Table S3), educational attainment (Table S4), total cholesterol (Table S5), HDL cholesterol (Table S6), LDL (with remnant) cholesterol (Table S7), Total:HDL cholesterol ratio (Table S8), waist-to-hip ratio (Table S9), and percentage body fat (Table S10). (XLSX 159 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Epigenetic_prediction_of_c... |
| Title | Additional file 1: of Epigenetic prediction of complex traits and death |
| Description | DNAm signature CpGs and corresponding weights for BMI (Table S1), smoking (Table S2), alcohol consumption (Table S3), educational attainment (Table S4), total cholesterol (Table S5), HDL cholesterol (Table S6), LDL (with remnant) cholesterol (Table S7), Total:HDL cholesterol ratio (Table S8), waist-to-hip ratio (Table S9), and percentage body fat (Table S10). (XLSX 159 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Epigenetic_prediction_of_c... |
| Title | Additional file 2 of Characterisation of an inflammation-related epigenetic score and its association with cognitive ability |
| Description | Additional file 2: Table S1. CpG sites and relative weights (from Lighthart et al.) used to generate the DNAm CRP score. Table S2. SNPs and relative weights (from Dehghan et al.) used to generate the genetic score for CRP. Table S3. Summary of latent class analyses for log(CRP) and the DNAm CRP score in the Lothian Birth Cohort 1936. Table S4. Associations with determinants of CRP and the genetic CRP score. Table S5. Association between individual CpG sites and general cognitive ability (gf) in the Lothian Birth Cohort 1936 and Generation Scotland. Table S6. Longitudinal associations between the baseline DNAm CRP score and serum CRP and general cognitive ability (gf) over the four waves of follow-up in the Lothian Birth Cohort 1936. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_2_of_Characterisation_of_an_inflammatio... |
| Title | Additional file 2 of Characterisation of an inflammation-related epigenetic score and its association with cognitive ability |
| Description | Additional file 2: Table S1. CpG sites and relative weights (from Lighthart et al.) used to generate the DNAm CRP score. Table S2. SNPs and relative weights (from Dehghan et al.) used to generate the genetic score for CRP. Table S3. Summary of latent class analyses for log(CRP) and the DNAm CRP score in the Lothian Birth Cohort 1936. Table S4. Associations with determinants of CRP and the genetic CRP score. Table S5. Association between individual CpG sites and general cognitive ability (gf) in the Lothian Birth Cohort 1936 and Generation Scotland. Table S6. Longitudinal associations between the baseline DNAm CRP score and serum CRP and general cognitive ability (gf) over the four waves of follow-up in the Lothian Birth Cohort 1936. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_2_of_Characterisation_of_an_inflammatio... |
| Title | Additional file 2 of Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults |
| Description | Additional file 2: Supplementary Tables. The association of pre-adjusted protein levels with biological and technical covariates. Protein levels were adjusted for age, sex, array plate and four genetic principal components (population structure) prior to analyses. Significant associations are emboldened. (Table S1). pQTLs associated with inflammatory biomarker levels from Bayesian penalised regression model (Posterior Inclusion Probability > 95%). (Table S2). All pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10- 10). (Table S3). Summary of lambda values relating to ordinary least squares GWAS and EWAS performed on inflammatory protein levels (n = 70) in Lothian Birth Cohort 1936 study. (Table S4). Conditionally significant pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10- 10). (Table S5). Comparison of variance explained by ordinary least squares and Bayesian penalised regression models for concordantly identified SNPs. (Table S6). Estimate of heritability for blood protein levels as well as proportion of variance explained attributable to different prior mixtures. (Table S7). Comparison of heritability estimates from Ahsan et al. (maximum likelihood) and Hillary et al. (Bayesian penalised regression). (Table S8). List of concordant SNPs identified by linear model and Bayesian penalised regression and whether they have been previously identified as eQTLs. (Table S9). Bayesian tests of colocalisation for cis pQTLs and cis eQTLs. (Table S10). Sherlock algorithm: Genes whose expression are putatively associated with circulating inflammatory proteins that harbour pQTLs. (Table S11). CpGs associated with inflammatory protein biomarkers as identified by Bayesian model (Bayesian model; Posterior Inclusion Probability > 95%). (Table S12). CpGs associated with inflammatory protein biomarkers as identified by linear model (limma) at P < 5.14 × 10- 10. (Table S13). CpGs associated with inflammatory protein biomarkers as identified by mixed linear model (OSCA) at P < 5.14 × 10- 10. (Table S14). Estimate of variance explained for blood protein levels by DNA methylation as well as proportion of explained attributable to different prior mixtures - BayesR+. (Table S15). Comparison of variance in protein levels explained by genome-wide DNA methylation data by mixed linear model (OSCA) and Bayesian penalised regression model (BayesR+). (Table S16). Variance in circulating inflammatory protein biomarker levels explained by common genetic and methylation data (joint and conditional estimates from BayesR+). Ordered by combined variance explained by genetic and epigenetic data - smallest to largest. Significant results from t-tests comparing distributions for variance explained by methylation or genetics alone versus combined estimate are emboldened. (Table S17). Genetic and epigenetic factors identified by BayesR+ when conditioning on all SNPs and CpGs together. (Table S18). Mendelian Randomisation analyses to assess whether proteins with concordantly identified genetic signals are causally associated with Alzheimer's disease risk. (Table S19). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Multi-method_genome-_and_e... |
| Title | Additional file 2 of Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults |
| Description | Additional file 2: Supplementary Tables. The association of pre-adjusted protein levels with biological and technical covariates. Protein levels were adjusted for age, sex, array plate and four genetic principal components (population structure) prior to analyses. Significant associations are emboldened. (Table S1). pQTLs associated with inflammatory biomarker levels from Bayesian penalised regression model (Posterior Inclusion Probability > 95%). (Table S2). All pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10- 10). (Table S3). Summary of lambda values relating to ordinary least squares GWAS and EWAS performed on inflammatory protein levels (n = 70) in Lothian Birth Cohort 1936 study. (Table S4). Conditionally significant pQTLs associated with inflammatory biomarker levels from ordinary least squares regression model (P < 7.14 × 10- 10). (Table S5). Comparison of variance explained by ordinary least squares and Bayesian penalised regression models for concordantly identified SNPs. (Table S6). Estimate of heritability for blood protein levels as well as proportion of variance explained attributable to different prior mixtures. (Table S7). Comparison of heritability estimates from Ahsan et al. (maximum likelihood) and Hillary et al. (Bayesian penalised regression). (Table S8). List of concordant SNPs identified by linear model and Bayesian penalised regression and whether they have been previously identified as eQTLs. (Table S9). Bayesian tests of colocalisation for cis pQTLs and cis eQTLs. (Table S10). Sherlock algorithm: Genes whose expression are putatively associated with circulating inflammatory proteins that harbour pQTLs. (Table S11). CpGs associated with inflammatory protein biomarkers as identified by Bayesian model (Bayesian model; Posterior Inclusion Probability > 95%). (Table S12). CpGs associated with inflammatory protein biomarkers as identified by linear model (limma) at P < 5.14 × 10- 10. (Table S13). CpGs associated with inflammatory protein biomarkers as identified by mixed linear model (OSCA) at P < 5.14 × 10- 10. (Table S14). Estimate of variance explained for blood protein levels by DNA methylation as well as proportion of explained attributable to different prior mixtures - BayesR+. (Table S15). Comparison of variance in protein levels explained by genome-wide DNA methylation data by mixed linear model (OSCA) and Bayesian penalised regression model (BayesR+). (Table S16). Variance in circulating inflammatory protein biomarker levels explained by common genetic and methylation data (joint and conditional estimates from BayesR+). Ordered by combined variance explained by genetic and epigenetic data - smallest to largest. Significant results from t-tests comparing distributions for variance explained by methylation or genetics alone versus combined estimate are emboldened. (Table S17). Genetic and epigenetic factors identified by BayesR+ when conditioning on all SNPs and CpGs together. (Table S18). Mendelian Randomisation analyses to assess whether proteins with concordantly identified genetic signals are causally associated with Alzheimer's disease risk. (Table S19). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Multi-method_genome-_and_e... |
| Title | Additional file 2: of Association of facial ageing with DNA methylation and epigenetic age predictions |
| Description | Table S1: Descriptive information for the 1000 most correlated CpGs with face-age. Table S2: Top 1000 face-age-CpG associations from EWAS model 1 . Table S3: Top 1000 face-age-CpG associations from EWAS model 2. Table S4: Top 1000 face-age-CpG associations from EWAS model 3. Table S5: 32 CpG predictor of face-age built from the top 100 CpGs reported in Table S4. (XLSX 240 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_2_of_Association_of_facial_ageing_with_... |
| Title | Additional file 2: of Association of facial ageing with DNA methylation and epigenetic age predictions |
| Description | Table S1: Descriptive information for the 1000 most correlated CpGs with face-age. Table S2: Top 1000 face-age-CpG associations from EWAS model 1 . Table S3: Top 1000 face-age-CpG associations from EWAS model 2. Table S4: Top 1000 face-age-CpG associations from EWAS model 3. Table S5: 32 CpG predictor of face-age built from the top 100 CpGs reported in Table S4. (XLSX 240 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/Additional_file_2_of_Association_of_facial_ageing_with_... |
| Title | Additional file 3: of Epigenetic prediction of complex traits and death |
| Description | Table S11. Prediction of traits with and without genetic scores. Table S12. Cox proportional hazards survival models output for phenotypic, epigenetic (DNAm), and genetic (polygenic) predictors of health and lifestyle factors. (XLSX 14 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Epigenetic_prediction_of_c... |
| Title | Additional file 3: of Epigenetic prediction of complex traits and death |
| Description | Table S11. Prediction of traits with and without genetic scores. Table S12. Cox proportional hazards survival models output for phenotypic, epigenetic (DNAm), and genetic (polygenic) predictors of health and lifestyle factors. (XLSX 14 kb) |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Epigenetic_prediction_of_c... |
| Title | Brain Images of Normal Subjects (BRAINS) Imagebank |
| Description | The Brain Images of Normal Subjects (BRAINS) imagebank is an integrated repository project sponsored by the University of Edinburgh and the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) collaborators. The purpose of BRAINS is to provide sharing and archiving of detailed normal human brain imaging and relevant phenotypic data, to create better estimates of the range of normal brain size and integrity across the life-course. The Lothian Birth Cohort 1921 and 1936 brain imaging data along with limited clinical data has been added to this resource. BRAINS is a living imagebank where new data will be added when available. Initially BRAINS will contain existing data from n=763 healthy volunteer subjects, range neonatal and 19-81 years of age, from projects in 3 centres. A further n=2119 subjects aged from prenatal to 90 years old with existing records from 15 other projects in Scotland are currently being collected, collated and quality control (QC) checked. Additional completed and ongoing studies of normal individuals will be uploaded as they become available. The data include several magnetic resonance imaging (MRI) sequences, including T1, T2, T2*, fluid attenuated inversion recovery (FLAIR), and Diffusion Tensor Imaging (DTI), in DICOM and NIfTI format, and a wide range of linked metadata, such as age, history, physiological measures (e.g. blood pressure), cognitive ability, and perinatal information (neonatal data). Data access is governed by a steering committee comprising the PIs of the contributing studies, experts in ethics, law and governance, and lay representatives. Applications for data access can be made online, and will be granted by the steering committee subject to the completion of a formal Data Access Agreement. http://www.brainsimagebank.ac.uk/ |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The initial publication which describes the resource was: "A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)" Dominic E Job, David A Dickie, David Rodriguez, Andrew Robson, Cyril Pernet, Mark Bastin, James P Boardman, Alison D Murray, Trevor Ahearn, Gordon D Waiter, Roger T Staff, Ian J Deary, Susan D Shenkin, Joanna M Wardlaw. NeuroImage. doi: 10.1016/j.neuroimage.2016.01.027 PMID: 26794641. We have developed seven age-specific atlases of T1 brain MRI from 25 to 92 years, which have been made available on the BRAINS website. Dickie, David Alexander; Job, Dominic E.; Rodriguez, David; Robson, Andrew; Danso, Samuel; Pernet, Cyril; Bastin, Mark E.; Deary, Ian J.; Shenkin, Susan D.; Wardlaw, Joanna M.. (2016). Brain Imaging of Normal Subjects (BRAINS) age-specific MRI atlases from young adults to the very elderly (v1.0), [dataset]. University of Edinburgh, Edinburgh Imaging, CCBS, BRAINS Imagebank. http://dx.doi.org/10.7488/ds/1369. |
| URL | http://www.brainsimagebank.ac.uk |
| Title | Dataset For: Smoking Does Not Accelerate Leukocyte Telomere Attrition: A Meta-Analysis Of 18 Longitudinal Cohorts |
| Description | Summary dataset (.csv file) and R script (.R file) for the manuscript entitled: Smoking does not accelerate leukocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts. The column names are explained at the beginning of the R script. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://zenodo.org/record/1240964 |
| Title | Enhancing the Scottish Mental Survey 1947 - Matthew Iveson |
| Description | Dr Iveson is involved in developing the Scottish Mental Survey 1947 cohort, linking existing research data to historical administrative records (birth records from 1935-1937 available from Digitising Scotland), to current administrative records (Scottish Census 2001 and 2011) and to novel health records (Prescribing Information System). This is an extension of previous linkages, and improves the utility of the Scottish Mental Survey 1947 cohort as a research tool. The links are to be retained so that future researchers can request linked data for the cohort without the need to re-trace records from scratch. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | The database is under development but will be available to other researchers in 2019 |
| Title | Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins |
| Description | Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (P<1.3×10-7) using a longitudinal epigenome-wide association study design. We measured how estimated cellular compositions changed with age and how much they confounded the age effect. We validated the results in two independent longitudinal cohorts, where 118 CpGs were replicated in Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, 390 samples) (P<3.9×10-5), 594 in Lothian Birth Cohort (LBC, 3018 samples) (P<5.1×10-5) and 63 in both. Functional annotation of age-associated CpGs showed enrichment in CCCTC-binding factor (CTCF) and other transcription factor binding sites. We further investigated genetic influences on methylation and found no interaction between age and genetic effects in the 1316 age-associated CpGs. Moreover, in the same CpGs, methylation differences within twin pairs increased with 6.4% over 10 years, where monozygotic twins had smaller intra-pair differences than dizygotic twins. In conclusion, we show that age-related methylation changes persist in a longitudinal perspective, and are fairly stable across cohorts. The changes are under genetic influence, although this effect is independent of age. Moreover, methylation variability increase over time, especially in age-associated CpGs, indicating the increase of environmental contributions on DNA methylation with age. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://tandf.figshare.com/articles/dataset/Epigenetic_influences_on_aging_a_longitudinal_genome-wid... |
| Title | Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins |
| Description | Age-related changes in DNA methylation were observed in cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize longitudinal age-related methylation patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic and 96 dizygotic pairs) up to five times (mean 2.6) over 20 years (mean 8.7). We identified 1316 age-associated methylation sites (P<1.3×10-7) using a longitudinal epigenome-wide association study design. We measured how estimated cellular compositions changed with age and how much they confounded the age effect. We validated the results in two independent longitudinal cohorts, where 118 CpGs were replicated in Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, 390 samples) (P<3.9×10-5), 594 in Lothian Birth Cohort (LBC, 3018 samples) (P<5.1×10-5) and 63 in both. Functional annotation of age-associated CpGs showed enrichment in CCCTC-binding factor (CTCF) and other transcription factor binding sites. We further investigated genetic influences on methylation and found no interaction between age and genetic effects in the 1316 age-associated CpGs. Moreover, in the same CpGs, methylation differences within twin pairs increased with 6.4% over 10 years, where monozygotic twins had smaller intra-pair differences than dizygotic twins. In conclusion, we show that age-related methylation changes persist in a longitudinal perspective, and are fairly stable across cohorts. The changes are under genetic influence, although this effect is independent of age. Moreover, methylation variability increase over time, especially in age-associated CpGs, indicating the increase of environmental contributions on DNA methylation with age. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | https://tandf.figshare.com/articles/dataset/Epigenetic_influences_on_aging_a_longitudinal_genome-wid... |
| Title | MOESM2 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 2: Table S2. DAVID Analysis confirms enrichment of synaptic proteins. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM2_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM2 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 2: Table S2. DAVID Analysis confirms enrichment of synaptic proteins. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM2_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM3 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 3: Table S3. IPA analysis output. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM3_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM3 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 3: Table S3. IPA analysis output. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM3_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM4 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 4: Table S4. Evidence for alterations in proteins involved in the complement cascade in human AD synapses. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM4_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM4 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 4: Table S4. Evidence for alterations in proteins involved in the complement cascade in human AD synapses. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM4_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM5 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 5: Table S5. Proteomics raw data. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM5_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM5 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 5: Table S5. Proteomics raw data. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM5_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM6 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 6: Table S6. Filtered proteomics data used for IPA analysis in Fig. 3. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM6_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | MOESM6 of Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype |
| Description | Additional file 6: Table S6. Filtered proteomics data used for IPA analysis in Fig. 3. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/MOESM6_of_Comparative_profiling_of_the_synaptic_proteom... |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V3 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V12 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V2 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V1 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V13 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V17 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V5 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V16 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/web/NACDA/studies/2760 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V18 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/web/NACDA/studies/2760/versions/V19 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V6 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V7 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V9 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V15 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V4 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V10 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V14 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V8 |
| Title | Midlife in the United States (MIDUS 1), 1995-1996 |
| Description | The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu. The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74. Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ. This updated version of the study is comprised of three primary datasets: Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future. The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file. Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone. Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses. Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities. MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required. |
| Type Of Material | Database/Collection of data |
| Year Produced | 1999 |
| Provided To Others? | Yes |
| URL | https://www.icpsr.umich.edu/icpsrweb/NACDA/studies/2760/versions/V11 |
| Title | Model sensitivity to missing data |
| Description | A new procedure of longitudinal model sensitivity analysis to missing data has been developed and is described in: Allerhand, M., Gale, C. R., Deary, I, J. (2014). The dynamic relationship between cognitive function and positive wellbeing in older people: a prospective study using the English Longitudinal Study of Ageing. Psychology and Aging. 29(2), 306-318. doi:10.1037/a0036551. |
| Type Of Material | Data handling & control |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | The procedure has been described in the following publication: Allerhand, M., Gale, C. R., Deary, I, J. (2014). The dynamic relationship between cognitive function and positive wellbeing in older people: a prospective study using the English Longitudinal Study of Ageing. Psychology and Aging. 29(2), 306-318. doi:10.1037/a0036551. |
| Title | Novel data analysis method - Mike Allerhand |
| Description | Novel data analysis method: Questionnaire item bias by continuous covariates. http://www.ccace.ed.ac.uk/research/allerhand |
| Type Of Material | Data analysis technique |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Providing a statistical service. |
| URL | http://www.ccace.ed.ac.uk/research/allerhand |
| Title | SRD-17-0117 - Supplemental material for Leveraging Multiple Machine-Learning Techniques to Predict Major Life Outcomes from a Small Set of Psychological and Socioeconomic Variables: A Combined Bottom-up/Top-down Approach |
| Description | Supplemental material, SRD-17-0117 for Leveraging Multiple Machine-Learning Techniques to Predict Major Life Outcomes from a Small Set of Psychological and Socioeconomic Variables: A Combined Bottom-up/Top-down Approach by Drew M. Altschul in Socius |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://sage.figshare.com/articles/SRD-17-0117_Supplemental_material_for_Leveraging_Multiple_Machine... |
| Title | SRD-17-0117 - Supplemental material for Leveraging Multiple Machine-Learning Techniques to Predict Major Life Outcomes from a Small Set of Psychological and Socioeconomic Variables: A Combined Bottom-up/Top-down Approach |
| Description | Supplemental material, SRD-17-0117 for Leveraging Multiple Machine-Learning Techniques to Predict Major Life Outcomes from a Small Set of Psychological and Socioeconomic Variables: A Combined Bottom-up/Top-down Approach by Drew M. Altschul in Socius |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://sage.figshare.com/articles/SRD-17-0117_Supplemental_material_for_Leveraging_Multiple_Machine... |
| Description | "Short-term memory binding: validity as a cognitive biomarker for Alzheimer's disease across cultures and nations" - funded by Alzheimer's Society |
| Organisation | Cayetano Heredia University |
| Country | Peru |
| Sector | Academic/University |
| PI Contribution | We have provided the methodology to undertake this project. I have met Dr Nilton Custodio during the World Congress of Neurology, celebrated in Chile in 2015 and in the AAIC 2016 in Toronto. I have met the team via teleconferences during which we have been assembling the team that will support this study locally. |
| Collaborator Contribution | The Peruvian Institute of Neuroscience runs a 3-year longitudinal study as part of the programme of the title. This involved assessing elderly people from Peru living in urban and rural areas and with different levels of education ad languages |
| Impact | Data collection in progress. As part of the meeting held in Santiago in 2015 to which other experts of Latin American Country attended, including Prof. Ricardo Nitrini from Brazil, Prof. Francisco Lopera, from Colombia and Prof. Facundo Manes from Argenitina, we prepared a Policy Paper to raise awareness about challenges in Latin America countries. This paper is submitted for publication. |
| Start Year | 2016 |
| Description | "Short-term memory binding: validity as a cognitive biomarker for Alzheimer's disease across cultures and nations" - funded by Alzheimer's Society |
| Organisation | Del Rosario University |
| Country | Colombia |
| Sector | Academic/University |
| PI Contribution | We have provided the methodology to undertake this project. I have visited and trained at The Institute of Psychology, Universidad de Valle and have delivered talks to the professional community, undergraduate and postgraduate students. I have been involved in assembling the clinical and neuroimaging team that will support this study locally. |
| Collaborator Contribution | The Institute of Psychology of the above University of is supporting a 3-year longitudinal study on MCI. This involves behavioural, EEG and MRI measures of cognitive decline in elderly people with MCI. In collaboration with the Foundation Valle del Lili, we have secured funding for a 3-year longitudinal study using fMRI to follow up patents with MCI. |
| Impact | 1) Expanded the UK-Latin America Brain Connectivity Research Network (Heriot-Watt University - and HCN University of Edinburgh, UK - Cali, Colombia). 2) A new research agenda has been launched that comprises behavioural and neuroimaging study of MCI patients all funded by local institutions. |
| Start Year | 2016 |
| Description | Air pollution exposure - Russ |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Two projects are being undertaken with the Swedish team. 1. "Are epigenetic changes associated with air pollution exposure in the SATSA cohort?" 2016 - Karolinska Institutet, Sweden. Contributions: This work is at a preliminary stage but we are cleaning the data and hope to begin analysing them soon. 2. "Is air pollution associated with neuroimaging changes" - Karolinska Institutet, Sweden. Contributions: This work is at a preliminary stage but we are cleaning the data and hope to begin analysing them soon. |
| Collaborator Contribution | Sharing Joint research expertise. |
| Impact | No outcomes to date as the collaboration is very new. |
| Start Year | 2016 |
| Description | Allerhand - BMI and cognitive ageing (2013) |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | The Centre's statistician is engaged in a collaborative research project on BMI and cognition. |
| Collaborator Contribution | This is a collaborative research project. Previously, a researcher from Karolinska has visited the Centre. |
| Impact | Publications are forthcoming. |
| Start Year | 2013 |
| Description | Allerhand - BMI and cognitive ageing (2013) |
| Organisation | University of California, Riverside |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | The Centre's statistician is engaged in a collaborative research project on BMI and cognition. |
| Collaborator Contribution | This is a collaborative research project. Previously, a researcher from Karolinska has visited the Centre. |
| Impact | Publications are forthcoming. |
| Start Year | 2013 |
| Description | Assessment of category fluency in ageing - MacPherson |
| Organisation | Korea Advanced Institute of Science and Technology (KAIST) |
| Department | Computer Science Department |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | As a result of Challenge Investment funding, University of Edinburgh, my colleague Dr Maria Wolters and I made our first visit to our new collaborator, Professor Jong C. Park, School of Computing, KAIST, South Korea in February 2015. We have started examining traditional and acoustic data from semantic fluency, as well as, manual and semi-automated scoring methods for the task in both healthy and pathological aging. The School of Computing have devised the automated scoring methods and my contribution is the design and interpretation of our fluency work. |
| Collaborator Contribution | As a result of Challenge Investment funding, University of Edinburgh, my colleague Dr Maria Wolters and I made our first visit to our new collaborator, Professor Jong C. Park, School of Computing, KAIST, South Korea in February 2015. We have started examining traditional and acoustic data from semantic fluency, as well as, manual and semi-automated scoring methods for the task in both healthy and pathological aging. The School of Computing have devised the automated scoring methods and my contribution is the design and interpretation of our fluency work. |
| Impact | Papers published and others in preparation. |
| Start Year | 2015 |
| Description | Biomarkers for dementia and cognitive ageing - Russ |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I will analyse the data. |
| Collaborator Contribution | Glasgow will analyse urinary proteomic samples . |
| Impact | None as yet. |
| Start Year | 2015 |
| Description | CCACE - Oregon Health and Sciences University (OHSU) |
| Organisation | Oregon Health and Science University |
| Department | Layton Aging & Alzheimer's Disease Center |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | CCACE hosted a visit from the Oregon Health and Sciences University team of senior scientists (8 people) in September 2013. The aim was to develop more formal collaborations between the UK and USA in ageing research. The team spent 2 days with CCACE in various meet the staff meetings. |
| Collaborator Contribution | The OHSU team have offered to host 3 members of CCACE on a return visit to Oregon in February 2014. Further correspondence has taken place between Dr Alex WEiss and Professor Jean Manson and the team at Oregon and planned collaborations are ongoing. |
| Impact | There are plans to create formal collaborations between CCACE and OHSU scienitsts that will result after the reciprocal visit. This is intended to lead to joint publications between CCACE and OHSU. |
| Start Year | 2013 |
| Description | Cognitive estimation in an Italian population - MacPherson |
| Organisation | Fondazione IRCCS Istituto Nazionale dei Tumori |
| Country | Italy |
| Sector | Charity/Non Profit |
| PI Contribution | My collaborators translated into Italian the new versions of the Cognitive Estimation task (CET) devised by me (MacPherson et al., 2014, PLOS-One) and administered the tasks to the healthy population to examine the influence of age, gender and education on performance and providing Italian normative data. We are now examining whether non-demented Parkinson's disease patients are impaired on the CET and what underlies their impairments. My collaborators have assessed the participants, ran the statistical analyses and wrote drafts of the manuscripts. I have devised the tests, provided the theoretical input into the work and have also contributed to the writing of the manuscripts. |
| Collaborator Contribution | My collaborators translated into Italian the new versions of the Cognitive Estimation task (CET) devised by me (MacPherson et al., 2014, PLOS-One) and administered the tasks to the healthy population to examine the influence of age, gender and education on performance and providing Italian normative data. We are now examining whether non-demented Parkinson's disease patients are impaired on the CET and what underlies their impairments. My collaborators have assessed the participants, ran the statistical analyses and wrote drafts of the manuscripts. I have devised the tests, provided the theoretical input into the work and have also contributed to the writing of the manuscripts. |
| Impact | It has resulted in new versions of a test that is typically used in neuropsychological clinics in Italy. |
| Start Year | 2015 |
| Description | Collaboration with the University of Texas at Austin and the Vrije Universiteit Amsterdam - David Hill |
| Organisation | Free University of Amsterdam |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | David Hill performed several genome wide association studies. |
| Collaborator Contribution | The group leaders were responsible for the development of the genomic SEM method. |
| Impact | This collaboration resulted in the method of Genomic SEM being published in Nature Human Behaviour. |
| Start Year | 2017 |
| Description | Collaboration with the University of Texas at Austin and the Vrije Universiteit Amsterdam - David Hill |
| Organisation | University of Texas at Austin |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | David Hill performed several genome wide association studies. |
| Collaborator Contribution | The group leaders were responsible for the development of the genomic SEM method. |
| Impact | This collaboration resulted in the method of Genomic SEM being published in Nature Human Behaviour. |
| Start Year | 2017 |
| Description | Cox - Interconnectivity of Cerebral Sites - Colab. Pilot |
| Organisation | Lagos State University |
| Department | Department of Computer Science |
| Country | Nigeria |
| Sector | Academic/University |
| PI Contribution | Provided the concept and neuranatomical basis for development of a study specific method for identifying and measuring white matter connectivity between cerebral regions in older participants. |
| Collaborator Contribution | The proposed study represents an international collaborative effort that marries expertise in neuropsychology, neuroanatomy, computer science and ageing research. |
| Impact | A method for exploiting manual frontal lobe parcellations to measure specific site-to-site white matter connectivity in the brains of older persons. In addition to the method development, several manuscripts are planned which will examine the cognitive correlates of individual differences in intra-frontal and fronto-hippocampal connections. Preliminary results presented at two conferences (OHBM 2014 by Aribisala, and ISMRMB 2014 by Cox). Manuscript in preparation, collaboration with Psychiatry at UoE (Prof Lawrie) using this method in preliminary stages. Additional development work planned for use in the Lothian Birth cohorts. |
| Start Year | 2013 |
| Description | Delbox as an activation task - Tieges |
| Organisation | Johns Hopkins University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Collaborative projects (until 2018) between the University of Edinburgh and Johns Hopkins University, US: Use of Delbox as an activation task-associated with attention in measurement of brain function using functional near-infrared spectroscopy (fNIRS). The Delbox will be used in several studies which are supported by Hitachi with funding and equipment. |
| Collaborator Contribution | Their academic expertise. |
| Impact | The first scientific paper is submitted. |
| Start Year | 2016 |
| Description | EU Joint programme - Neurodegenerative Disease Research |
| Organisation | Lille University Hospital |
| Country | France |
| Sector | Hospitals |
| PI Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Collaborator Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Impact | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Start Year | 2013 |
| Description | EU Joint programme - Neurodegenerative Disease Research |
| Organisation | Medical University of Graz |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Collaborator Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Impact | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Start Year | 2013 |
| Description | EU Joint programme - Neurodegenerative Disease Research |
| Organisation | Paris Diderot University |
| Country | France |
| Sector | Academic/University |
| PI Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Collaborator Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Impact | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Start Year | 2013 |
| Description | EU Joint programme - Neurodegenerative Disease Research |
| Organisation | Technical University of Munich |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Collaborator Contribution | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Impact | This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research". |
| Start Year | 2013 |
| Description | Genetics Team Lead for the PREVENT Dementia cohort study - Riccardo Marioni |
| Organisation | University of Edinburgh |
| Department | Division of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I was invited to be the Genetics Team Lead for the PREVENT Dementia cohort study. We are finalising the collection of baseline data in the 700 participants and will start generating omics data in Spring 2019. |
| Collaborator Contribution | Their expertise |
| Impact | Data collection begins this spring |
| Start Year | 2018 |
| Description | Geographical variation and environmental risk factors for dementia - Russ |
| Organisation | Health Statistics Unit |
| Country | Italy |
| Sector | Public |
| PI Contribution | Analyse data available on dementia risk factors in an Italian population study. |
| Collaborator Contribution | Provide data. |
| Impact | Brief report due to be submitted for publication with other papers planned. |
| Start Year | 2015 |
| Description | Geographical variation and environmental risk factors for dementia in Chile - Russ |
| Organisation | University of Talca |
| Country | Chile |
| Sector | Academic/University |
| PI Contribution | This work is at a preliminary stage but my Chilean colleagues have provide data and I have analysed them |
| Collaborator Contribution | Provided data. |
| Impact | Brief report about to be submitted for publication; others planned. |
| Start Year | 2015 |
| Description | Geographical variation and environmental risk factors for dementia in Japan - Russ |
| Organisation | Hokkaido University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | This work is at a preliminary stage but my Japanese colleagues have agreed to collaborate and provide data; I will analyse these. |
| Collaborator Contribution | This work is at a preliminary stage but my Japanese colleagues have agreed to collaborate and provide data; I will analyse these. |
| Impact | None as yet. |
| Start Year | 2015 |
| Description | Geographical variation and environmental risk factors for dementia in New Zealand - Russ |
| Organisation | Auckland University of Technology (AUT) |
| Country | New Zealand |
| Sector | Academic/University |
| PI Contribution | This is at a preliminary stage. We are discussing availability of data and an exchange visit by Dr Katherine Walesby is planned for this year. |
| Collaborator Contribution | Provide data. |
| Impact | None as yet. |
| Start Year | 2015 |
| Description | Geographical variation in dementia - Russ |
| Organisation | Rush University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Applied to use their Religious Orders Study data and this has recently been approved. |
| Collaborator Contribution | Provided data. |
| Impact | Publications are being prepared. |
| Start Year | 2015 |
| Description | Gow - A Tablet for Healthy Ageing |
| Organisation | University of Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Gow contributed to the development of a new research programme, A Tablet for Healthy Ageing, including obtaining funding from The Dunhill Medical Trust. |
| Collaborator Contribution | Contributed to the development of a new research programme, A Tablet for Healthy Ageing, including obtaining funding from The Dunhill Medical Trust. |
| Impact | This is a new research programme to develop a supported intervention programme utilising tablet PCs and other technologies to improve the health and well-being of older adults. The programme received funding from The Dunhill Medical Trust and is employing a post-doctorate research fellow based at Heriot Watt University. |
| Start Year | 2014 |
| Description | Gow - School of Built Environment, Heriot Watt University |
| Organisation | Heriot-Watt University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contributing expertise in cognitive ageing to a paper looking at housing built year and residence duration using the US NHANES study. |
| Collaborator Contribution | Contributing expertise in the built environment to a paper looking at housing age and residence duration and cognitive function. |
| Impact | This collaboration resulted in a paper which is currently under review, and a further application to access UK Biobank data. Shiue, I. & Gow, A. J. (under review). Housing built year and residence duration are associated with cognitive function in the elderly: US NHANES, 1999-2002. |
| Start Year | 2014 |
| Description | Human episodic memory - Davies/Deary |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Title: Integrated systems approach identifies genetic nodes and network for human episodic memory This collaboration is based in the UK. Genome-wide association analyses of memory phenotypes were performed on the Lothian Birth Cohorts in an attempt to replicate findings from a co-expression network analysis performed on human hippocampus samples. |
| Collaborator Contribution | See above |
| Impact | We were able to successfully replicate these findings and a manuscript has been submitted. This collaboration is multi-disciplinary, it involves genetics, psychology (cognition), genomic medicine, Clinical neurogenetics, and neurology. |
| Start Year | 2014 |
| Description | Human episodic memory - Davies/Deary |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Title: Integrated systems approach identifies genetic nodes and network for human episodic memory This collaboration is based in the UK. Genome-wide association analyses of memory phenotypes were performed on the Lothian Birth Cohorts in an attempt to replicate findings from a co-expression network analysis performed on human hippocampus samples. |
| Collaborator Contribution | See above |
| Impact | We were able to successfully replicate these findings and a manuscript has been submitted. This collaboration is multi-disciplinary, it involves genetics, psychology (cognition), genomic medicine, Clinical neurogenetics, and neurology. |
| Start Year | 2014 |
| Description | International genetics collaboration investigating runs of homozygosity (ROHgen) |
| Organisation | University of Edinburgh |
| Department | Centre for Population Health Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is an international collaboration investigating the effects of runs of homozygosity on a number of health-related traits including cognition. Manuscript in preparation. |
| Collaborator Contribution | This is an international collaboration investigating the effects of runs of homozygosity on a number of health-related traits including cognition. Manuscript in preparation. |
| Impact | Manuscript published. |
| Start Year | 2014 |
| Description | Interstellar Initiative |
| Organisation | Columbia University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Selected for the Japan Agency for Medical Research and Development and the New York Academy of Sciences' Interstellar Initiative (March 2017-February 2018). I am one of 50 international early career researchers in neuroscience, regenerative medicine, and cancer selected for this scheme which consists of two intensive funding bid development meetings with mentoring hosted by the NYAS and $40,000 funding for each team of two or three to enhance their application to funding agencies. |
| Collaborator Contribution | Academic expertise. |
| Impact | None as yet. |
| Start Year | 2017 |
| Description | Interstellar Initiative |
| Organisation | Osaka University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Selected for the Japan Agency for Medical Research and Development and the New York Academy of Sciences' Interstellar Initiative (March 2017-February 2018). I am one of 50 international early career researchers in neuroscience, regenerative medicine, and cancer selected for this scheme which consists of two intensive funding bid development meetings with mentoring hosted by the NYAS and $40,000 funding for each team of two or three to enhance their application to funding agencies. |
| Collaborator Contribution | Academic expertise. |
| Impact | None as yet. |
| Start Year | 2017 |
| Description | Lingo Flamingo social enterprise |
| Organisation | Social Enterprise UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Intellectual and research expertise to measure the cognitive effects of language learning on older adults. |
| Collaborator Contribution | Provide language courses and tutors to adult learners. |
| Impact | None to date as the collaboration has only recently formed. |
| Start Year | 2016 |
| Description | MAGIC - international glycaemic traits genetics consortium |
| Organisation | MAGIC |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | The is an international glycaemic traits genetics consortium. Current work is focussed on analysis of exome chip data. |
| Collaborator Contribution | The is an international glycaemic traits genetics consortium. Current work is focussed on analysis of exome chip data. |
| Impact | Manuscript in preparation. |
| Start Year | 2014 |
| Description | MRC Integrative Epidemiology Unit in Bristol partnership - David Hill |
| Organisation | University of Bristol |
| Department | MRC Integrative Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | My contributions to this were to supply data, as well as to assist in the interpretation and write up of the manuscript |
| Collaborator Contribution | Perform the analyses, and to draft the manuscript. |
| Impact | This has resulted in two papers submitted (Anderson, E. L., (2019) and Davies et al., (20019)). Both of these manuscripts utilise bivariate Mendelian randomisation to examine the unique effects education and intelligence have on Alzheimer's disease and a broad range of health and anthropometric variables. |
| Start Year | 2017 |
| Description | Molecular genetic data to inform about the causes of socioeconomic differences - David Hill |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | David Hill leads a project aiming to use molecular genetic data to inform about the causes of socioeconomic differences. |
| Collaborator Contribution | MRC Integrative Epidemiology Unit in Bristol performed a causal analysis using the data provided by David Hill. Karolinska Institutet, UCL Institute of Neurology in London, provided access to data on cell-type specific gene expression found in cortical tissues. NHS Blood and Transplant, Oxford and the National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge provided GWAS data. |
| Impact | David Hill is currently working on corrections of the manuscript that details the project's findings. |
| Start Year | 2017 |
| Description | Molecular genetic data to inform about the causes of socioeconomic differences - David Hill |
| Organisation | NHS Blood and Transplant (NHSBT) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | David Hill leads a project aiming to use molecular genetic data to inform about the causes of socioeconomic differences. |
| Collaborator Contribution | MRC Integrative Epidemiology Unit in Bristol performed a causal analysis using the data provided by David Hill. Karolinska Institutet, UCL Institute of Neurology in London, provided access to data on cell-type specific gene expression found in cortical tissues. NHS Blood and Transplant, Oxford and the National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge provided GWAS data. |
| Impact | David Hill is currently working on corrections of the manuscript that details the project's findings. |
| Start Year | 2017 |
| Description | Molecular genetic data to inform about the causes of socioeconomic differences - David Hill |
| Organisation | The National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | David Hill leads a project aiming to use molecular genetic data to inform about the causes of socioeconomic differences. |
| Collaborator Contribution | MRC Integrative Epidemiology Unit in Bristol performed a causal analysis using the data provided by David Hill. Karolinska Institutet, UCL Institute of Neurology in London, provided access to data on cell-type specific gene expression found in cortical tissues. NHS Blood and Transplant, Oxford and the National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge provided GWAS data. |
| Impact | David Hill is currently working on corrections of the manuscript that details the project's findings. |
| Start Year | 2017 |
| Description | Molecular genetic data to inform about the causes of socioeconomic differences - David Hill |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | David Hill leads a project aiming to use molecular genetic data to inform about the causes of socioeconomic differences. |
| Collaborator Contribution | MRC Integrative Epidemiology Unit in Bristol performed a causal analysis using the data provided by David Hill. Karolinska Institutet, UCL Institute of Neurology in London, provided access to data on cell-type specific gene expression found in cortical tissues. NHS Blood and Transplant, Oxford and the National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge provided GWAS data. |
| Impact | David Hill is currently working on corrections of the manuscript that details the project's findings. |
| Start Year | 2017 |
| Description | Molecular genetic data to inform about the causes of socioeconomic differences - David Hill |
| Organisation | University of Bristol |
| Department | MRC Integrative Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | David Hill leads a project aiming to use molecular genetic data to inform about the causes of socioeconomic differences. |
| Collaborator Contribution | MRC Integrative Epidemiology Unit in Bristol performed a causal analysis using the data provided by David Hill. Karolinska Institutet, UCL Institute of Neurology in London, provided access to data on cell-type specific gene expression found in cortical tissues. NHS Blood and Transplant, Oxford and the National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics, University of Cambridge provided GWAS data. |
| Impact | David Hill is currently working on corrections of the manuscript that details the project's findings. |
| Start Year | 2017 |
| Description | Risk factors for dementia - Russ |
| Organisation | University of Tokyo |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | "Geographical variation in and environmental risk factors for dementia in Japan" 2016 - Tokyo University, Japan & Oita University, Japan. Contributions: This work is at a preliminary stage but my Japanese colleagues have agreed to collaborate and provide data; I will analyse these. |
| Collaborator Contribution | Japanese colleagues have agreed to collaborate and provide data |
| Impact | None as yet. Papers are underway. |
| Start Year | 2016 |
| Description | Scottish Data Linkage and Sharing Service / NRS |
| Organisation | Government of Scotland |
| Department | Data Sharing and Linkage Service (DSLS) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | The research team contributed expertise in cognitive epidemiology and feedback on our experiences of data linkage. Ultimately the team will contribute data from the Scottish Mental Survey 1947. The team also suggested a suitable consultant for completion of a scoping project, and hosted and supervised that consultant for the duration of the 3-month project. |
| Collaborator Contribution | The NRS team will contribute linkage between SMS1947 and National Registration 1939 databases. Funds were provided for consultancy work as part of a scoping project to identify suitable databases for linkage. |
| Impact | The linkage between SMS1947 and 1939 national registration databases will enhance the tracing of the SMS1947 group. The scoping project led to the production of an extensive report on the use of the SMS1947 as a 'pathfinder' project for the new Data Sharing and Linkage Service currently under development in Scotland. |
| Start Year | 2013 |
| Description | Scottish Data Linkage and Sharing Service / NRS |
| Organisation | National Records of Scotland |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | The research team contributed expertise in cognitive epidemiology and feedback on our experiences of data linkage. Ultimately the team will contribute data from the Scottish Mental Survey 1947. The team also suggested a suitable consultant for completion of a scoping project, and hosted and supervised that consultant for the duration of the 3-month project. |
| Collaborator Contribution | The NRS team will contribute linkage between SMS1947 and National Registration 1939 databases. Funds were provided for consultancy work as part of a scoping project to identify suitable databases for linkage. |
| Impact | The linkage between SMS1947 and 1939 national registration databases will enhance the tracing of the SMS1947 group. The scoping project led to the production of an extensive report on the use of the SMS1947 as a 'pathfinder' project for the new Data Sharing and Linkage Service currently under development in Scotland. |
| Start Year | 2013 |
| Description | UK Biobank |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provide statistical analysis and expertise on the cognitive and personality associated variables in a large collaboration aimed at studying associations between behavioural and medical outcomes in UK Biobank. |
| Collaborator Contribution | They provide expertise in epidemiology and psychiatric disorders. |
| Impact | Publications: 24884621, 24336235 , 24282498 |
| Start Year | 2013 |
| Description | UK Dementia Platform |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample. |
| Collaborator Contribution | As above. |
| Impact | This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. |
| Start Year | 2013 |
| Description | UK Dementia Platform |
| Organisation | Johnson & Johnson |
| Country | United States |
| Sector | Private |
| PI Contribution | Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample. |
| Collaborator Contribution | As above. |
| Impact | This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. |
| Start Year | 2013 |
| Description | UK Dementia Platform |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample. |
| Collaborator Contribution | As above. |
| Impact | This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. |
| Start Year | 2013 |
| Description | UK Dementia Platform |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample. |
| Collaborator Contribution | As above. |
| Impact | This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. |
| Start Year | 2013 |
| Description | UK Dementia Platform |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample. |
| Collaborator Contribution | As above. |
| Impact | This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. |
| Start Year | 2013 |
| Title | APPARATUS AND METHOD FOR TESTING SUSTAINED ATTENTION AND DELIRIUM |
| Description | A patent has been filed for a new computerised instrument for the detection of attentional deficits in delirium (the "Delbox"). The University of Edinburgh has filed a patent to cover the key features of the DelApp test and patents have now been granted in the US and in Europe: US 9307940 'Apparatus and Methods for testing sustained attention and Delirium'; EP 2485645 'Testing Apparatus and Method'. Key data informing the patents were provided from the original, smaller MRC Developmental Pathway |
| IP Reference | EP2485645 |
| Protection | Patent granted |
| Year Protection Granted | 2012 |
| Licensed | No |
| Impact | The 'Delbox' mark 2 has now been developed as a result of an MRC Development Pathway Funding Scheme grant and is currently being tested on patients and volunteers, some of whom are accessed using CCACE resources. It has attracted interest from research groups outwith Edinburgh and once we have completed the validation work over the next few months we will make it commercially available. This process is still ongoing. |
| Title | DelApp - Tieges |
| Description | The software source code for the current prototype of the DelApp has been written by Lothian NHS co-investigators on the project. The source code is protected by copyright. |
| IP Reference | |
| Protection | Copyrighted (e.g. software) |
| Year Protection Granted | 2016 |
| Licensed | No |
| Impact | This software has led to the development of potential clinical tool: DelApp. This is a software test for detecting attentional deficits in delirium [at the validation stage]. The value of the DelApp study was recognised in the oral presentation prize being awarded at the European Delirium Association meeting in November 2016. |
| Title | Liewald-Cox Heatmapper - Dave Liewald, Simon Cox |
| Description | Developed by the CCACE database manager Dave Liewald and CCACE Associate Simon Cox, the Heatmapper tool allows the quick and simple creation of high resolution figures to illustrate associations between variables of interest and sub-regions of the brain's cortex. |
| Type Of Technology | Software |
| Year Produced | 2016 |
| Open Source License? | Yes |
| Impact | Beta version will be released in Spring 2016, and the first outputs are part of a publication in preparation: Cox SR, Bastin ME, Ritchie SJ, Dicke DA, Liewald DC, Munoz Maniega S, Redmond P, Royle NA, Pattie A, Valdes Hernandez MdelC, Corley J, Aribisala BS, McIntosh AM, Wardlaw JM, Deary IJ. Brain cortical characteristics of lifetime cognitive ageing. It will also be used to illustrate the results of future cortical analyses conducted by CCACE members in both the LBC and UK Biobank cohorts, and also used more widely by other researchers once it becomes available via the CCACE website. |
| Title | R package to implement Thomson's bonds model |
| Description | The Centre's statistician, Dr Mike Allerhand, developed an R package in order to implement the Bonds theory of intelligence first proposed by Godfrey Thomson. It has been described in: Bartholomew D. J, Allerhand M., Deary I. J., (2013). Measuring mental capacity: Thomson's bonds model and Spearman's g-model compared. Intelligence. 41:222-233. |
| Type Of Technology | Software |
| Year Produced | 2013 |
| Open Source License? | Yes |
| Impact | The package is distributed open source through the Centre's website. |
| Title | Reference Tracts and Generative Models for Brain White Matter Tractography |
| Description | These were created and presented at Medical Image Understanding and Analysis: 21st Annual Conference, 2017, and the citation is the first paper above. These reference tracts improved the automatic segmentation of brain white matter tracts from diffusion MRI, and demonstrated that matching models can be successfully transferred to novel data. The availability of these tracts and models make the use of probabilistic neighborhood tractography in small testing datasets possible as it can bypass the need for training data. They have been made available through the "TractoR MRI analysis project" (http://www.tractor-mri.org.uk). TractoR is free software, available under the GPL licence. The reference tracts are referred to in here http://www.tractor-mri.org.uk/reference-tracts. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2017 |
| Open Source License? | Yes |
| Impact | The availability of these tracts and models make the use of probabilistic neighborhood tractography in small testing datasets possible as it can bypass the need for training data. |
| URL | http://www.tractor-mri.org.uk |
| Description | "Financial Abuse of Older People" - Stuart Ritchie |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | February 18 2016: took part in a seminar on Financial Abuse of Older People at Age UK, alongside members of the police, policymakers, and charity workers. |
| Year(s) Of Engagement Activity | 2016 |
| Description | 'AgeWell' annual event - Stuart Ritchie |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | September 1 2016: gave a talk on the LBC1936 to the 'AgeWell' annual event (general public audience) at the University of Birmingham. |
| Year(s) Of Engagement Activity | 2016 |
| Description | A Day in the Life of Edinburgh Neuroscience |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | CCACE also collaborated with Edinburgh Neuroscience on a short film Ages of the Brain: a Day in the Life of Edinburgh Neuroscience. Using film and sound clips submitted by research groups from across CCACE and Edinburgh Neuroscience, we put together a short film on the variety of Neuroscience research across Edinburgh, with a special emphasis on the ageing brain. The film premiered at a joint event on 30 June and has since been viewed on YouTube over 1,400 times (https://youtu.be/zQqIH5yY3-c). |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://youtu.be/zQqIH5yY3-c |
| Description | ARUK donor talk - Riccardo Marioni |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | • Alzheimer's research communication to ~20 trustees and donors of Alzheimer's Research UK (Oct 2018) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Adam Smith Institute's 'Forum' event - Stuart Ritchie |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | December 3 2016: gave a talk on intelligence generally, including LBC1936 data, for the Adam Smith Institute's 'Forum' event (audience: general public). |
| Year(s) Of Engagement Activity | 2016 |
| Description | Age UK Bake Sale |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | CCACE core staff and members help a bake sale in aid of Age UK in February 2016. The charity event was held in the Department of Psychology and was open to anyone who wanted to buy. Prizes were awarded for the cake that best linked to an area of research or study, and the most amusing design. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Age UK Disconnected Mind Internal Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Presentations given by Drs Cox, Ritchie and Morton and Prof Deary to Age UK staff from across the organisation about study findings. This was followed by breakout sessions to discuss how the findings can be incorporated into Age UK practices. January 2015 |
| Year(s) Of Engagement Activity | 2015 |
| Description | Age UK For Later Life Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | This is the annual conference of the UK's largest charity devoted to helping older people, Age UK. Professor Deary addressed the whole meeting on the topic of healthy cognitive ageing, ensuring a broad UK reach to workers in the older-age charity sector. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Age UK Symposium on Financial Abuse |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Stuart Ritchie contributed to a panel discussion/symposium held at Age UK in London in February 2016 on financial abuse of older people. The panel included representatives from Age UK, the Metropolitan Police, banks (HSBC, Santander, Lloyd's), and other academics. Dr Ritchie used research findings from the Lothian Birth Cohorts to discuss how age-related cognitive decline might increase vulnerability to financial abuse in older persons. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Age UK staff on LBC1936 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Third sector organisations |
| Results and Impact | Age UK is one of the main founders of Professor Deary's Lothian Birth Cohorts projects on healthy cognitive ageing. This talk was one of a number given by Professor Deary and team members to a large number of workers at Age UK in order to bring them up to date with the aims, findings, and practical applications of the teams research on cognitive ageing. It is used by Age UK in order to produce information, including books and website information, on the risks and protective factors for normal cognitive ageing which is highly important for their members. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Ageing brain, ageing mind. Senior men's group - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presentation about cognitive and brain ageing for a senior men's group, followed by questions and discussion. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Ageing intervention research at HWU - Alan Gow |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Third sector organisations |
| Results and Impact | Ageing intervention research at HWU. Roundtable presentation to Age Scotland, Heriot-Watt University, Edinburgh, UK, 27th March 2018. Local/national reach - impact was in developing new networks and connections between researchers in ageing/brain health at HWU and national charity partner (Age Scotland). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Artist collaboration - "The Strategy of the Genes" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The artwork is made by Penelope Kay, Artist in Residence at the invitation of Prof. Andrew McIntosh. The concept for the artwork is inspired by Dr. Pippa Thomson, Lecturer in Psychiatric Genetics and Group Leader at the Institute of Genetics and Molecular Medicine (IGMM), Edinburgh. The art project involves creating a 3D object that can be installed in either an art or science space and can be interacted with by the viewer, who might be a member of the public or a scientist. The object will resemble a board game where the playing pieces relate to the coded information used by geneticists. The board will be 50x50cm, and can placed on a freestanding table for exhibition. |
| Year(s) Of Engagement Activity | 2017 |
| Description | BBC Filming of Dementia Buddies Scheme |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The BBC came to our research facility and filmed us having conversations with patients about their lived experience with dementia. We also gave the patients a tour of the facility and a seminar on our work. The footage was shown on BBC Scotland TV, radio and bbc.co.uk. Many people got in touch afterwards looking to take part. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-46589662 |
| Description | BBC Radio 4 (Today programme) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with a researcher for BBC Radio 4 (Today Programme) about playing musical instruments and cognitive ageing based on an LBC research paper, followed by requests for more information and further media mentions |
| Year(s) Of Engagement Activity | 2023 |
| Description | BBC Radio Scotland Brainwaves: How To Stay Sharp - Alan Gow |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Alan Gow contributed to the BBC Radio Scotland programme Brainwaves, presented by Pennie Latin (broadcast 7 and 11 February 2018). Alan discussed lifestyle factors that contribute to healthy cognitive ageing. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.bbc.co.uk/programmes/b09qqmfg |
| Description | BBC Radio Scotland Personal Best : Giving and Receiving - Alan Gow |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Alan Gow contributed to the BBC Radio Scotland programme Personal Best, presented by Gillian Russell (broadcast 17 and 22 December 2018). The programme explored the topics of health and wellbeing. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bbc.co.uk/programmes/m0001mxz |
| Description | BBC Radio Scotland Personal Best: Couples' Coaching Cards & Growth Mindset - Alan Gow |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Alan Gow contributed to the BBC Radio Scotland programme Personal Best, presented by Gillian Russell: Couples' Coaching Cards & Growth Mindset (broadcast 12 and 17 February 2018). Alan Gow described the of impact different activities on thinking skills in older age. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.bbc.co.uk/programmes/b09rk6s7 |
| Description | BBC Scotland documentary: Who lives in Scotland? Episode 2: Health, Wealth and Happiness |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Researchers and participants were interviewed about the study and findings for a BBC documentary. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bbc.co.uk/programmes/m001dlbm |
| Description | BBC The Twinstitute - Thomas Bak |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC Show "The Twinstitute" participation with TH Bak. Carried out cognitive testing post-course and brief appearance in the show. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://twitter.com/EdinUniCAHSSres/status/1093182434185801728 |
| Description | BBC Trust me I'm a doctor - Thomas Bak |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Carried out cognitive testing and actively participated and contributed to research for the BBC programme "Trust me I am a doctor" alongside my research colleagues. Appearance in the show. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/BBCTrustMe/status/1037415820392116224 |
| Description | BBC1 television series "Holding back the years" |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Bill Turnbull, star of BBC's Breakfast News TV, Strictly Come Dancing, Classic FM etc., came to the Psychology department on 23rd January 2017 with a BBC film crew to find out about the Lothian Birth Cohort 1936 (LBC1936)/Disconnected Mind study. BBC1 are planning a series in the Spring called 'Holding back the years'. Each programme will feature a celebrity revisiting a place that means a lot to them, and the programmes will have a focus on the processes of human ageing. Mr Turnbull was at the University of Edinburgh in the 1970's (he shared a flat with Gordon Brown for a term!), and so his programme is based here. It was natural that, to find out more about ageing, and with an Edinburgh locus, he and the BBC filming team visited the LBC1936. A busy afternoon's filming was filled with his interviewing LBC1936 Director Ian Deary, speaking with about a dozen of the LBC1936 participants, and seeing and taking part in some cognitive testing. Look out for the series, especially the Edinburgh-based Bill Turnbull programme in a few months' time. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.ccace.ed.ac.uk/node/340 |
| Description | BMJ picture of the week |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The 'Picture of the Week' in the BMJ (Vol 348, issue 7964) showed two brain tractography images from the Brain Research Imaging Centre and from the Clinical Research Imaging Centre, both part of Edinburgh Neuroscience at the University of Edinburgh. The larger picture is from the LBC cohort (Lothian Birth Cohort) courtesy of Dr. Mark Bastin. The image has now been seen by a wide variety of people including public and collaborators/peers. It raises awareness of our brain and cognitive work among healthy older people, and helps people understand the advances which imaging science have made in illustrating age-related brain changes. |
| Year(s) Of Engagement Activity | 2014 |
| Description | BRAINS workshop August 2014 - Wardlaw |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | The workshop in August 2014 aimed to introduce the "Brain images of normal subjects" bank, which is being developed by imaging centres across Scotland. the aim is to collect data from across the lifecourse in order to create BRAINS atlases and support image analysis research and clinical reporting of brain images. Widened interest in the BRAINS bank and informed peers and public about its existence and usefulness. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Bak - Bilingualism media coverage |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Two papers of Bak's published in November 2013 (Alladi et al, Neurology) and June 2014 (Bak et al, Annals of Neurology) produced great interest in the media with ca. 400 press reports across the world for each of them (including North & South America, most of Europe, Middle East, India and China), in popular (USA Today, Metro) as well as high reputation (Der Spiegel, Corriere della Sera) newspapers. This included full interviews (Observer, El Mundo) as well as radio and TV interviews (BBC, Canadian TV). The BBC article devoted to this work was the most tweeted one on the day of publication (2 June 2014). The interest persists with regular invitations for interviews. Together with Bilingualism Matters (BM) and The Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) I conducted a twitter session in July 2014 and applied for a joint event at the Edinburgh Science Festival in April 2015. The Principal has sent Bak a personal letter of acknowledgement and selected his work to feature in the Annual Review of the University. When the communications office at the University of Edinburgh tried to estimate the number of media outlets which this story reached, it ran to the hundreds, covering many international television, radio and printed and web-based news outlets. Together with CCACE, Bak has applied to run a joint event at the Edinburgh International Science Festival in April 2015. 'Speaking Two Languages Benefits the Ageing Brain' YouTube video has been watched over 2,400 times http://youtu.be/emNrOSLJseo. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://youtu.be/emNrOSLJseo |
| Description | Bak - Cambridge Bilingualism network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Thomas Bak was invited to give a talk on 'Bilingualism across the lifespan' at the Cambridge Bilingualism Network at Cambridge University in 2014. This talk covered research findings using data from the Lothian BIrth Cohort 1936. This was an excellent opportunity to showcase Bak's work on bilingualism and ageing, using data from the Lothian Birth Cohort 1936 study. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Bak - dementia, aphasia and movement disorders |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Thomas Bak regularly presents talks to patient and carer groups, in the area of dementia, aphasia and movement disorders (often under the auspices of charities such as Alzheimer Society or Progressive Supranuclear Palsy PSP Association). The positive feedback received from these events is exemplified by a message he got from one of the organisers: "Just a note to thank you so much for such a thoughtful and helpful presentation on Tuesday. We all benefited greatly from your extensive understanding of this challenging illness and your clear empathy with people & their carers who are coming to terms with the diagnosis and adjusting to life and all the uncertainty they face. It was so encouraging to hear of an approach which looked at what is preserved and not just at the decline in capacity". |
| Year(s) Of Engagement Activity | 2014 |
| Description | Being smart and staying smart - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation 'Being smart and staying smart' to the Genetics and Genomics Principal Investigators' Group, Roslin Institute, University of Edinburgh. Edinburgh, UK, July 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Brain Box |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The CCACE Director and Knowledge Exchange Officer have been involved in the development of a 'Brain Box'. This is a portable workshop/festival resource to excite children and adults about the brain, how it works and the changes it goes through in a lifetime. It is a resource for guided workshops, festivals, exhibitions and events that would over time develop an online 'personality' tweeting about its day with photos, comments and quotes: see it on Twitter @brainboxone. This project is still in the development phase and received £4956 from the MRC Regional Communications Fund. Workshops are being planned as part of the Edinburgh International Science Festival 14-18 April 2015. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Brain Imaging Update. Lothian Birth Cohort Reunion Event. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Presentation of findings to participants, funders and collaborators of the Lothian Birth Cohorts. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.lothianbirthcohort.ed.ac.uk/news-archive |
| Description | Brain Training on Trial - Alan Gow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation exploring issues related to the brain training industry, at the Edinburgh Festival Fringe as part of Skeptics on the Fringe, Edinburgh Skeptics Society, Edinburgh, UK, 20th August 2018. |
| Year(s) Of Engagement Activity | 2011,2018 |
| Description | Brain Training on Trial Fringe show |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gow developed and delivered an hour-long show, "Brain Training on Trial", as part of the Edinburgh Festival Fringe, under the banner of Edinburgh Beltane's Cabaret of Dangerous Ideas. The show was attended by around 60 people. The trailer on You Tube had 533 views and 5 likes. The event itself sparked discussion and questions afterwards. Gow produced a "summing-up" video on 20th October 2014, which has had 68 views on You Tube. Gow also wrote a blog article on the subject of Brain Training on Trial on the Research the Headlines blog, which is followed by 88 people. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://researchtheheadlines.org/2014/09/09/brain-training-on-trial/ |
| Description | Bringing intelligence to life - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Bringing intelligence to life. Invited address to the Human Genetics Group, Wellcome Genome Campus, Hinxton, Cambridge. Cambridge, UK, March 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | British Academy debate 29th April 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Centre director, Ian Deary, presented the work of the Centre as part of a debate entitled The best years of our lives? on 29th April 2014. This was very well attended - around 300 people - and well publicised by the British Academy and beyond. The debate was chaired by well-known broadcaster Sally Magnusson (who recently wrote a book on dementia which had extended interviews with Ian Deary and John Starr), and also had contributions from Age UK's Professor James Goodwin, Alzheimers Scotland's Henry Simmons, and Professor Catharine Ward-Thompson. The event was well publicised and recordings of the debate made available through social media and the British Academy website. There was a lively discussion after the debate. |
| Year(s) Of Engagement Activity | 2014 |
| Description | CCACE - Training courses |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | In 2012, 2013 and 2014 CCACE ran a number of short taining courses. These included "introduction to R programming", "longitudinal modelling", and "systematic reviews and meta-analysis". R programming course has run 7 times between 2012-2014 with over 200 attendees. SR course - 2 sessions. Dec 2012 (n = 16), November 2013 (n = 18). Longitudinal modelling - 1 session in November 2013 (n = 50). We have increased the visibility of CCACE and the skills that we can offer to a wider academic audience. |
| Year(s) Of Engagement Activity | 2012,2013,2014 |
| URL | http://www.ccace.ed.ac.uk/students-training/training |
| Description | CCACE Social Media |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | CCACE has a significant following on social media (912 on Facebook; 701 on Twitter). Over the past year, the most watched research video was A Slower DNA Clock Predicts Longer Life by Dr Riccardo Marioni (https://youtu.be/bmpv-LDuL7s), viewed 748 times. |
| Year(s) Of Engagement Activity | 2014,2015 |
| URL | https://youtu.be/bmpv-LDuL7 |
| Description | CCACE YouTube channel ccacevideo |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Since 2011 CCACE has posted 29 videos about events, research and the Centre on its YouTube channel. The CCACE video channel has 36 subscribers and its videos have been viewed 13,302 times (as of 7th November 2014). |
| Year(s) Of Engagement Activity | 2011,2012,2013,2014 |
| URL | http://www.youtube.com/ccacevideo |
| Description | CCACE celebrates Scottish research cohorts |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Event held at Edinburgh's General Assembly Hall, June 2018. Hundreds of participants and researchers from Scottish cohort studies came together to celebrate their contribution to, and crucial role in, healthcare research. The day's programme covered research across the entire human lifespan, beginning with a presentation by Professor James Boardman on effects of premature birth, and ending with a talk from Professor David Batty on regional disparities in mortality. The event also offered a unique opportunity to survey the opinion of current Scottish cohort participants on future uses and sharing of their data. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=GJBbqOq4qa8 |
| Description | CCACE eNewsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Centres' Knowledge Exhange Officer produces a quarterly CCACE Newsletter detailing news and updates of Centre acitivity. The Summer 2014 newsletter was circulated to 447 recipients with 190 (43%) opening it and 83 (19%) clicking on several of its links. For the Winter 2013/14 newsletter these figures were 446, 209 (47%) and 89 (20%). In November 2011 this is circulated to a distribution list of over 220. Statistics from the January 2011 edition showed that ~60% opened the newsletter, and ~40% clicked on several of its links. |
| Year(s) Of Engagement Activity | 2010,2011,2012,2013,2014 |
| Description | CCACE media coverage |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 21 Mar 2014 - LBC1921/1936 feature in review of UK population studies by MRC 17 April 2014 - LBC reunion covered by STV News Spring 2014 MRC Network- coverage of Ian Deary's workspace 12th May 2014 "Edinburgh and Aberdeen depression study given £4.7m funds" - BBC News,; STRADL 11 June 2014- 9pm 'Frontier's - BBC Radio 4, - Latest thinking about our brain power in old age (Lothian Birth Cohort) 2 Jul 2014 - BRIC picture of the week 17 Jul 2014 - Bilingualism: Thomas Bak's paper - multiple media coverage. Answered live questions Bilingualism Matters; "Learning second language 'slows brain ageing'', BBC News June 2nd; The Australian news June 2nd; YouTube video >3,000 views: http://youtu.be/emNrOSLJseo 11 Aug 2014 - Stuart Ritchie on Infinite Monkey Cage - 11 Aug 2014 - Stuart Ritchie - visual processing and age on Good Morning Scotland, BBC Radio Scotland. YouTube video http://youtu.be/vWkgP5sWCNA 9 Oct 2014 - UK Dementia Platform Press Release http://www.ed.ac.uk/news/2014/dementia-190614 YouTube Video: http://youtu.be/xyer_t-X3lQ 30 Oct 2014 Science Magazine Article http://t.co/LxkPicGrvi 6 Nov 2014 Height associated with increased risk of dementia. New study from Tom Russ http://t.co/73cNJzhk1U https://youtu.be/BojlhIJ_TI8 20 Nov 2014 Complex jobs protect memory - http://www.bbc.co.uk/news/health-30115497 3 Dec 2014 Genetic study of Memory (CHARGE Consortium) http://www.ed.ac.uk/news/2014/memory-261114 3 Dec 2014 Nice mention of recent @ccace results from @claudiahammond & @CathLoveday on @BBCRadio4's All in the Mind, at 24m 30: http://www.bbc.co.uk/programmes/b04svjbn Dec 2014 DM results appearing in Age UK's Report of Trustees (p. 19): http://www.ageuk.org.uk/Documents/EN-GB/Corporate/age_uk_annual_report_2013_14.pdf?dtrk=true 15 Jan 2015 BBC Breakfast does a nice story on The Disconnected Mind / Lothian Birth Cohort as it begins Wave 4. http://t.co/rHpVx8SVQI 20 Jan 2015 £15m boost for Scotland's gene research | News | http://www.ed.ac.uk/news/2015/scottishgenomes-120115 30 Jan 2015 DNA Clock helps predict lifespan http://youtu.be/bmpv-LDuL7s?a http://www.ed.ac.uk/news/2015/dnaclock-300115 http://www.independent.co.uk/news/science/dna-clues-could-predict-when-people-will-die-10014400.html 3 Feb 2015 Scientists @CCACE have identified genes associated with people's cognitive function-how we process information http://www.ed.ac.uk/news/2015/genes-030215 YouTube Video: http://t.co/7KSyLzvD6o 11 Feb 2015 Smokers tend to have thinner brain cortex http://www.independent.co.uk/news/science/smokers-have-thinner-brain-cortex-and-could-have-impaired-thinking-10039128.html Release: http://www.ed.ac.uk/schools-departments/clinical-sciences/edinburgh-imaging/news/smokers-cortex 1 Dec 2015 Does Being Bilingual Protect Your Brain? - Thomas Bak on All in the Mind, BBC Radio 4 http://www.bbc.co.uk/programmes/p039w8gf?ns_mchannel=social&ns_campaign=bbc_radio_4&ns_source=facebook&ns_linkname=radio_and_music 22 Dec 2016 - Advances in the Genetic Basis of Intelligence: articles in The Guardian and The Telegraph. Jan 2016 - STV News LBC participant Mr Scott and Dr Simon Cox interviewed about new National Museum of Scotland Exhibit. STV News (from 15:30) at http://player.stv.tv/episode/36pt/news-at-six-edinburgh-east-full/thu-07-jan-6-00-pm/ Jan 2016 - Health and Thinking Skills Linked to the Same Genes - |
| Year(s) Of Engagement Activity | 2014,2015,2016 |
| Description | CCACE on Facebook: CCACEedinburgh |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | CCACE launched its Facebook page in 2011 featuring photographs, video and news about CCACE 147 people have "liked" the page so far, and actively share CCACE's newsfeeds. |
| Year(s) Of Engagement Activity | 2011,2012,2013,2014 |
| URL | https://www.facebook.com/CCACEEdinburgh |
| Description | CCACE public engagegement activities |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Jan 28th 2014 - Presented Disconnected Mind and CCACE 3D brain at Age UK's reception at St James's Palace hosted by HRH Prince Charles, April 2014- LBC reunion To see coverage on STV visit http://news.stv.tv/east-central/272014-oaps-sit-same-test-for-eight-deca... April 29th 2014 - Big debate -- the best years of our lives? - British Academy May 16th 2014 - Gathering Intelligence: the life and work of Prof Sir Godfrey Thomson, 28 Oct 2014 Ian Deary presented at the launch of the Dementia Platform UK on 28 October 2015 at the Royal Society London 6 Nov 2014 - Lifelong Health and Wellbeing London - Zoe Tieges talks about development of DELBOX for diagnosis of delirium; Natalie Royle describes standardised ways of measuring older brains using brain imaging; Maria Valdez del Hernandez speaks about brain imaging stuff 19 Nov 2014 Ian Deary addressed the Age Scotland conference 20 Nov 2014 The Day Scotland Tested the Nations IQ part of Previously...Scotland's History Festival https://iqpreviously.eventbrite.co.uk 27 Nov 2014 Ian Deary gave keynote talk at Voluntary Health Scotland conference "Health, Wellbeing and Your Brain" 28th October 2014 - UK Dementia Platform launch, London, 14 Mar 2015 The Living Brain event at Cambo House Fife, 20 adults attended 3 hour session (talk from Ian Deary, interactive session with ID, RM and Helen Staton, showing of the Living Brain Film and open questions. 19 March 2015 Schools workshop at Davidsons Mains Primary School - 40 Children 9 April 2015 The Living Brain - Interactive panel discussion. Edinburgh International Science Festival - 80 Adult attendees. 14-18 April 2015 BrainBox Workshop - Edinburgh International Science Festival, National Museum of Scotland - 70 Children aged 8-12. 27 Aug 2015 Cabaret of Dangerous Ideas, Edinburgh Festival Fringe - Alan Gow presented "The Great British Brain Off" to 80 members of the general public. October 2015 - Age: What is your number? Midlothian Science Festival evening event, 30 adult attendees. November 2015 BrainBox Workshop - 20 Beaver Scouts. |
| Year(s) Of Engagement Activity | 2014,2015 |
| Description | CCACE quarterly newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | CCACE has produced a quarterly newsletter since 2008. The newsletter mailing list has a varied audience of lay and scientists. It summarises major achievements of the Centre and our recent news items. |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014,2015,2016 |
| URL | http://www.ccace.ed.ac.uk/news-events/latest |
| Description | Cabaret of Dangerous Ideas - Bak |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Edinburgh Fringe Festival, event attended by ca. 80 people (the second highest attendance in the series); after the show approached to write a blog for British Medical Journal, which later got published as a paper, and give an interview to the Fringe Radio. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://codi.beltanenetwork.org/event/codi-2016-language-lessons-on-the-nhs/thomas-bak/ |
| Description | Cafe Scientifique cockermouth - Pickersgill |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Martyn Pickersgill: 'Enhancing What? Enhancing Who? Enhancing Why? Social Aspects of the Human Enhancement Debate', Café Scientifique, Cockermouth, 19th November 2013 (speaker). Interest and enthusiasm shown by attendees. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Cambo Winter Talks Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Professor Deary gave a talk on normal cognitive ageing followed by lively discussion at this small science festival. It was a accompanied by activities related to cognitive ageing that were conducted by him and other members of the CCACE Centre. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Centre for Dementia Prevention annual winter conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Title: Centre for Dementia Prevention annual winter conference: "Preventing Dementia: Advice and Advances" Type: Public lecture Audience: General public, predominantly local November 2017 Description: Public lecture, 250 attended Impact: Improved understanding about recent advances in dementia prevention URLs: http://centrefordementiaprevention.com/2017/11/30/1753/ https://media.ed.ac.uk/search/searchkeyword/centre%20for%20dementia%20prevention |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://centrefordementiaprevention.com/2017/11/30/1753/ |
| Description | Centre for Educational Sociology Lecture - Lindsay Paterson |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Paterson, L. (2018), Scottish Education Policy: Why Surveys Matter, CES Briefing No. 66, June. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cognition and a Mediterranean diet research paper - Luciano |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | There was considerable media interest in a paper examining the link between consuming a Mediterranean diet and brain shrinkage. CCACE member, Michelle Luciano, gave Live TV interview on BBC Breakfast, pre-recorded TV interview for a South Korean News Channel, 2 Live radio Broadcasts (BBC Reporting Scotland, BBC 3 Counties), and 1 pre-recorded radio broadcast (Radio Forth) Various interviews were also given for print media: 5/01/17: (BBC online ) (i) (The Press and Journal) (The Belfast Telegraph) (The Daily Express) (The Sun) (Metro) (New Scientist online) (The Herald) (The LA Times online (USA)) (The Times) (The Independent) (The Daily Mail) (Huffington Post online) (NBC News online) (The Irish Examiner online (Ireland)) (The Edinburgh Evening News) (The Evening Express) (La Vanguardia (Spain)) (Indo-Asian New Service (India)) (U.S. Food Stafety (USA)) (herenciageneticayenfermedad blog (Argentina)) (Health News Review (USA)) (ForeignAffairs.co.nz (New Zealand)) (Yahoo! India) (Channel 3000 (USA)) (Proceso Digital (Honduras)) (Nutraceutical World (USA)) (Top Sante (France)) (Yahoo! Actualites (France)) (The Business Standard (India)) (MedIndia (India)) (Visao Online (Portugal)) (Slashdot (USA)) (WOAI (USA)) (The New York Times (USA)) (Radio-Canada (Canada)) (Carriere Adriatico (Italy)) (Expatica (Netherlands)) (Inc.com (USA)) (WWLP (USA)) (TVA Nouvelles (Canada)) (ladepeche.fr (France)) (China News Service (China)) (The New York Times online (USA)) (Adnkronos (Italy)) (CNN (USA)) (NBC News (USA)) (U.S. News & World Report (USA)) (EFE - International Service (Spain)) (The Irish Daily Mail (Ireland)) (MedIndia (India)) (Point (France)) (AGF (Netherlands)) (Gosalute (Italy)) (Panorama (Italy)) (The New Zealand Herald) (Health Daily Digest (India)) (International Business Times (USA)) (Newser (USA)) (El Semanario Limitless (Mexico)) (Tech Times (USA)) (Day (Argentina)) (NutraIngredients.com (France)) (Sunday World (Ireland)) (La Sicillia (Italy)) (Monthly Prescribing References (USA)) (ProHealth.com (USA)) (Courrier Picard (France)) (Digital Journal (USA)) (EMaxHealth (USA)) (Sarasota Herald-Tribune (USA)) |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cognitive epidemiology interview - Geoff Der |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | CCACE member Geoff Der has given an interesting and wide-ranging interview about his work on intelligence, which you can hear through the link below. It includes a discussion on childhood intelligence, longevity and health, effects of maternal smoking and breast feeding on children's intelligence, and sex differences in intelligence. Geoff told us, "This interview came about because a controversial blog post had claimed that intelligence was primarily inherited from one's mother and cited some of our work as important evidence of this. The blog gained a lot of publicity in the USA via social media and we were invited by the smartdrugsmarts website to give an interview on the research cited. However, before the interview could be arranged, a convincing rejoinder to the original blog had been published by the Forbes website. The smartdrugsmart website was still keen to go ahead with the interview as a more general piece about our research using the National Longitudinal Study of Youth. This is the result." |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://smartdrugsmarts.com/episode-158-intelligence-genetics/?utm_source=twitter&utm_campaign=post&u... |
| Description | Cohort and Longitudinal Studies Enhancement Resources conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This was an invited lecture in the evening following the Cohort and Longitudinal Studies Enhancement Resources' conference. It was at the British Library, it was ticketed at £8, and was sold out with a large waiting list. The lecture covered Professor Deary's team's work on healthy cognitive ageing using the follow-up studies of the Scottish Mental Surveys. The full lecture is available online at the CLOSER website. This was a good opportunity to spread the word on the research to a mixed group[p of longitudinal cohort researchers, lay public, and charity sector workers. |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.youtube.com/watch?v=0rxgundtPTI |
| Description | Cox & Davies - U3A East Lothian |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Talk given by Simon Cox and Gail Davies to the University of the 3rd Age Haddington Science Group, East Lothian, UK. Title: Brain, genes and cognitive ageing in the Lothian Birth Cohort studies. May 2015. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cox - Cafe Scientifique, Cockermouth |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr. Simon Cox gave a talk to the Café Scientifique in Cockermouth entitled: 'Postcards from your brain; we wish we were there. On the (mis)uses of brain imaging'. Illustrations of brain imaging were distributed to attendees in postcard form, and examples from the Disconnected Mind study among others were discussed as instances of appropriate MRI data usage. Now developed, Simon will also give this talk at future knowledge exchange events. The talk was very successful with a great deal of interest and enthusiasm shown by attendees. Dr Cox hopes that this will lead to further invitations to similar events. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Cox - Colinton Literary Society, Feb 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Simon Cox presented a talk entitled New Adventures in Cognitive Ageing Research: The Lothian Birth Cohorts of 1921 & 1936 at The Colinton Literary Society, Edinburgh, UK. February. (c.50 attendees). The event was successful in disseminating information on the work of the Centre and Lothian Birth Cohort studies to members of the public. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Cox - DRCMR, Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk (Design, challenges and pitfalls in life span studies) on a week-long course for PhD students at the Danish Research Centre for Magnetic Resonance, University of Copenhagen. Attended by ~40 students and staff. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.drcmr.dk/events/event/166 |
| Description | Cox - Seniors USP launch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Cox SR (2014) Work Package 3: The Lothian Birth Cohort 1936. Seniors USP Dissemination Group Launch Day, Glasgow, UK. May. (c.15 attendees). This was an opportunity to share knowledge and plans for the MRC-funded Seniors USP study. It was attended by CCACE's collaborators and increased the opportunities for future collaborations and research. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary - AGE UK interview on Disconnected Mind / LBC1936 April 2014 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | This interview was a wide ranging description of the rationale for and achievements of the Disconnected Mind / Lothian Birth Cohort 1936 project for internal Age UK purposes. The aim was to inform a wide range of individuals within Age UK about the achievements of this cognitive ageing (and broader ageing) study in order that professionals within the Age UK charity organisation could be well informed when dealing with policy professionals external to the organisation and older people more generally. Age UK is the largest older age-related charity in the UK. They provide evidence to the UK government and more broadly, for example to the G7 conference. One example of the reach of the Disconnected Mind project is that the Age UK CEO, Tom Wright, delivered a talk to the G7 conference in November 2014 in Tokyo, and used evidence from the Disconnected Mind project in his slides. Also, Age UK were influential in urging the current Conservative government to undertake a large dementia initiative which was announced at the G7/G8 conference and could be partly credited for the MRC's dementias platform UK initiative. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.ageuk.org.uk/about-us/what-we-do/the-disconnected-mind/ |
| Description | Deary - British Academy Expert Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | With CCACE fellow-elect, Dr Stuart Ritchie, Ian Deary obtained funding for and organised this British Academy-funded workshop on processing speed and its importance for cognitive ageing in humans held in April 2014. Among the 13 attendees were international experts from the USA, Europe and the UK. Also, Professor James Goodwin for Age UK attended in order to achieve knowledge exchange and impact for the discussions. All of the discussions were audio recorded and slides made available. There were several impacts. First, Ian Deary and Stuart Ritchie wrote a summary article for British Academy Review and this made available the questions and discussion on processing speed to other academics. Second, Professor James Thompson of University College London extensively reported several of the talks with their Powerpoint slides on his much-read psychology blog, which reaches academics and lay people. Third, Professor James Goodwin took the results and their impact back to Age UK with a view to discussing how these were relevant to Age UK's aims in helping older people. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary - Glasgow Centre for Population Health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited seminar: Deary, I. J. (2014). Healthy cognitive ageing. Glasgow Centre for Population Health. Glasgow, UK, January. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary had drinks with the audience and had further discussion. A video of the talk was placed on the GCPH website and has been viewed many times. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary - Healthy ageing LBC studies Inner Wheel Club Edinburgh |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Deary, I. J. (2014). Healthy ageing: clues from the Lothian Birth Cohorts of 1921 and 1936. The Inner Wheel Club of Edinburgh. Edinburgh, UK, February. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took soup and sandwiches with the audience and had further discussion. After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary - Healthy cognitive ageing, York University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Ian Deary was invited to give a seminar on Healthy cognitive ageing at the University of York, October 2014. Interest and enthusiasm shown by attendees, and increased knowledge of the work of the Centre and LBC studies. The host, Dr Gary Lewis, after discussion with Professor Deary, has established plans for a new collaboration with the Lothian Birth Cohort studies. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary - Leith Probus Club |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited talk: Deary, I. J. (2013). The Lothian Birth Cohort 1936. Leith Probus Club. Edinburgh, UK, October. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took tea with the audience and had further discussion. After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary - MRC Network spring 2014 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The MRC's publication, Network, published an article on Centre Director Ian Deary's workspace, which showcased the work of the Centre in spring 2014. As is typical with these sorts of magazine-type articles, it attracted a lot of comment and attention, and many people, as a result, asked Professor Deary and colleagues about the history of the Scottish Mental Surveys and the work of the Lothian Birth Cohorts. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary - Pilrig St Paul's Guild, Edinburgh |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited talk: Deary, I. J. (2013). The Scottish Mental Surveys and healthy cognitive and brain ageing. Pilrig St Paul's Guild. Edinburgh, UK, November. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took tea with the audience and had further discussion. After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Deary Talk to Scottish Government Data Linkage Framework |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Deary was invited to present results from the follow-up studies of the Scottish Mental Surveys as an exemplar of data linkage to the Scottish Government Data Linkage Framework. The Scottish Mental Surveys as a resource formed an exemplar of data linkage, informing future government plans in data linkage services. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Della Sala - Treasure Island |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Sergio Della Sala was involved in advising on a schools engagement programme entitled "Treasure Island: Discussion Notes from a Neuroscience Perspective" during 2014. Interest and enthusiasm shown by pupils attending events in the programme. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Della Sala - false memories, Terra Mexico |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Sergio Della Sala commented on a study claiming that the mind creates false memories, Terra Mexico, 20th August 2014. This commentary was available in the public domain |
| Year(s) Of Engagement Activity | 2014 |
| Description | Della Sala - neurolinguistic programming, Wired.it |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Sergio Della Sala featured in an article on Wired.it speaking about how neurolinguistic programming as a science does not exist, 4th February 2014. This article was in the public domain. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Della Sala - tickling yourself, Sunday Times |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Sergio Della Sala featured in an article in The Sunday Times on 26th January 2014 on why it is not possible to tickle oneself. This article was in the public domain. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Dementia Buddies Scheme - Szu-Han Wang |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Knowledge exchange between patients with dementia and researchers working on the biological aspects of dementia. Patients and carers visit us at our research labs and we speak to them about their lived experience. This has sparked much discussion with the patients. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Disconnected Mind newsletter - 2013+ |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | The Disconnected Mind project, which includes the Lothian Birth Cohort 1936 study and involves many of the Centre's members, produces a quarterly newsletter summarising study progress, impact and the latest research findings. This is distributed to approximately 126 funders and research collaborators across the UK. The newsletter is sent to funders as well as research collaborators, and information on the study and its findings has been used by Age UK, the LBC1936 study's main funders, in their publications. |
| Year(s) Of Engagement Activity | 2013,2014 |
| Description | Does language learning lead to healthier ageing? - Thomas Bak |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Blog for MEITS website |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.meits.org/blog/post/does-language-learning-lead-to-healthier-ageing |
| Description | Drop-in activity at the Edinburgh International Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Staff and students from CCACE hosted a drop-in activity stand at the National Museum of Scotland, with the theme: 'How Old Are You Really?' The aim was to draw attention to the many ways - other than chronological age - that researchers of ageing try to measure how old someone is. In a sign of how well received the stand was, there were queues to enter everyday due to reaching maximum visitor capacity. |
| Year(s) Of Engagement Activity | 2009,2018 |
| Description | Edinburgh Festival Fringe - Alan Gow |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Edinburgh, UK, 18th August, 2017. What Keeps You Sharp? Show at the Edinburgh Festival Fringe as part of Edinburgh Beltane's Cabaret of Dangerous Ideas, Edinburgh, UK, 15th & 19th August 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Edinburgh International Science Festival - Jenni Burton |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited to participate in 'Scientists have your data' at the Edinburgh International Science Festival, organised by the ADRC-Scotland, the Farr Institute and the Usher Institute University of Edinburgh. Public engagement event. Contribution to session as data scientist, discussing care home data linkage, Summerhall, 3/4/17. Project on care home data linkage voted by audience to have the most demonstrable public benefit. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Edinburgh International Science Festival 2014 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | CCACE held an interactive stall in the Museum of Scotland as part of the family drop-in activities at the Edinburgh International Science Festival 15th-19th April 2014. This was visited by over 2000 people over the course of the week, including Age UK's Chief Executive, Tom Wright. The stall and activities showcased the work of the Centre, particularly the Lothian Birth Cohort studies. Children and parents were able to engage with many displays and objects relating to brain function and brain ageing. As in previous years many hundreds of people engaged with the Centre's representatives and illustrations of its work. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Edinburgh Speakers Festival - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The new Edinburgh Speakers Festival 2016 took place from 9th-11th September and our own CCACE Director was invited to be part of this year's prestigious line-up. Speakers covered a large variety of topics including cognitive ageing, devolution, politics, history, literature, fashion, Islam, capitalism, cycling, RBS, the Lockerbie bombing, whisky and women's equality, but all with a focus on Scotland. Ian's talk was entitled "Understanding Healthy Cognitive Ageing: Scotland's Unique Contribution" and took place on Saturday 10th September. This is what Ian said about the event: "Well" said Disconnected Mind Director Ian Deary, "That's the first time I have been on the same bill as Ken Livingstone and Ruth Davisdson! What an ecclectic programme." Ian spoke on healthy cognitive ageing to an audience at the Edinburgh Speakers Festival. Of course, the LBC1936's results were highlighted, with a focus on the likely protective factors for cognitive ageing. "There was a middle-aged finalist from this year's Brain of Britain Radio 4 show in the audience", said Ian, "so that was a good basis from which to explain how crystallised ability ages pretty well." As usual,the photos of Mr Scott and his brain images went down well with the enthusiastic attendees. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.ccace.ed.ac.uk/node/327 |
| Description | Evans - Brain Awareness Week schools workshop 2014 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Workshop for primary school children entitled "Who is the boss? How your brain runs your body" as part of the British Neuroscience Association's Brain Awareness Week, March 2014. The children appeared very interested and engaged. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Exhibition at Beautiful Brain Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | In person pre-conference display about history of the research group and research findings with 410 registered participants, with questions from attendees and request for further information and engagement. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://edinburghbioquarter.com/eicc-live-beautiful-brain/ |
| Description | Explorathon - Museum of Scotland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The Centre was represented at Explorathon, an event at the Museum of Scotland held in September 2014. There were presentations about the human brain with a host of interactive objects and displays so that people understood about the brain function and ageing. Interest and enthusiasm shown by members of the public at the event, including many young people, and increased awareness of the work of the Centre. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Faculty of Public Health Annual Scottish Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was a plenary invited keynote to the faculty of Public Health's annual conference. Professor Deary's talk was on healthy cognitive ageing, and he immediately followed and was heard by the Health Minister of the Scottish Government and her staff, as well as about 200 plus practitioners in public health. Therefore, it was a good opportunity to convey the work practitioners considering the important public health challenges for the Nation. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Festival activity (The Secrets of Healthy Cognitive Ageing walking tour) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Over 700 engaged with a self-guided walking tour via an online app, describing the history, findings and engagement activities of the Lothian Birth Cohorts study group. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://storymaps.arcgis.com/stories/b7485d181a41409b835a780a28c2c24b |
| Description | Frontiers BBC Radio 4 - LBC June 2014 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Results from the Lothian Birth Cohort studies were discussed by Ian Deary on BBC Radio 4's Frontiers programme, looking at the latest thinking about our brain power in old age. Robert Logie also discussed cognitive ageing on the programme. The Lothian Birth Cohort studies were discussed alongside Cambridge studies and a provocative idea that there might be much less cognitive ageing than these studies suggest. As a result, there was discussion in the media, which reached the Centre, about the LBC studies. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Gow - INAPIC workshop, University of Zurich |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Gow was invited to participate in a workshop entitled "Developmental Models of Brain-Behavior change relationships" held at the International Normal Aging and Plasticity Imaging Center, University of Zurich, on September 12-14 2013. Expertise and research was shared amongst a group of eminent international speakers, including the INAPIC Advisory Board. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Gow - keynote Active Ageing conference Oct 2014 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Keynote presentation at Active Ageing conference, Hamilton, October 2014. This was attended by more than 150 professionals and brought together representatives from partner agencies and older adults alike. The conference was reported through a variety of media channels, and many ideas and innovations were shared. |
| Year(s) Of Engagement Activity | 2014 |
| Description | HMC conference - Stuart Ritchie |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | October 4 2016: gave a talk on intelligence generally, including LBC1936 data, to the HMC conference (audience: headteachers) in Stratford |
| Year(s) Of Engagement Activity | 2016 |
| Description | HRH The Princes Royal |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | On the 6th July 2016 our University of Edinburgh Chancellor, HRH The Princess Royal, opened the new Centre for Dementia Prevention Building in the Bioquarter at Little France. The Centre for Dementia Prevention is led by Professor Craig Ritchie and aims to help society to understand what causes Dementia and then hopes to devise and implement strategies and lifestyle changes that will prevent Dementia from developing in the first place. CCACE was invited to this event as a complementary Centre working in ageing research at Edinburgh. Beverly Roberts represented CCACE at the opening in her role as Centre Scientific Administrator. After an initial tour of the new building, the Princes Royal was shown in to the reception marquee and introduced to a number of projects/Centres based at Edinburgh who work in both pathological and nonpathological ageing. When she was introduced to Beverly and CCACE, the Princes Royal showed great interest in the work of our members and asked why studying normal ageing was so important in the context of dementia. After the formal introductions there was an afternoon tea reception where Princess Anne was able to talk to some of the 120 invited guests. Beverly was very busy during this time speaking to lots of interested individuals wanting to know more about normal cognitive ageing. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.ccace.ed.ac.uk/node/326 |
| Description | Healthy ageing - protecting your brain - Alan Gow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation on factors related to brain health as part of the Spotlight on Science series at Exploration Day, Heriot-Watt University, Edinburgh, UK, 19th May 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Healthy cognitive ageing - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Deary, I. J. (2016). Healthy cognitive ageing. Iain Whyte House Group. North Queensferry, UK, February. Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Healthy cognitive ageing - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Deary, I. J. (2016). Healthy cognitive ageing. University of the Third Age Science Group. Edinburgh UK, March. Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Healthy cognitive ageing and the Lothian Birth Cohorts of 1921 and 1936 - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Deary, I. J. (2016). Healthy cognitive ageing and the Lothian Birth Cohorts of 1921 and 1936. The Senior Fellows Club of the Royal Colleges of Physicians and Surgeons of Edinburgh. Edinburgh, UK, May. Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Healthy cognitive ageing: findings from the Lothian Birth Cohorts - Ian Deary |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presentation to the Medico-Chirurgical Society of Edinburgh. Ian Deary summarised the Lothian Birth Cohorts studies and their many contributions to healthy cognitive ageing. This was followed by half an hour of questions and debate. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Hosting work experience pupils |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | CCACE hosted a series of work experience placements for pupils in s5/6 (secondary school). Pupils were given the opportunity to meet with CCACE members and observe some of the work of the Centre, including brain imaging, cognitive testing, and public engagement. These placements were a great success, with several schools expressing an interest in sending pupils to the Centre for work experience in the future. |
| Year(s) Of Engagement Activity | 2014 |
| Description | How to Age Well - Alan Gow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation on factors related to brain health as part of the Edinburgh Wellbeing Festival, Edinburgh, UK, 27th January 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | How to Have a Better Brain - Gow |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Our former LBC Team member Dr Alan Gow (now at Heriot-Watt University), still actively engaged in LBC research, featured in the first episode of the new Radio 4 series 'How to have a better brain', presented by Sian Williams. The series aims to deliver a practical guide to boosting brain functioning throughout life with topics including sleep, diet, relaxation and exercise. The first episode focusses on the effect of exercise on brain function and in his interview, Alan draws on research evidence from the LBC1936. The episode and the associated online-only segment are available on the BBC iPlayer (http://www.bbc.co.uk/programmes/b065ssr8; http://www.bbc.co.uk/programmes/p02zz7ql) |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/programmes/b065ssr8 |
| Description | Interview for a BBC podcast |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A researcher participated in an interview for The Compass (BBC World Service) for an episode Why we play?: Old age |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.bbc.co.uk/sounds/play/w3ct3033 |
| Description | Interviews for podcast with research team and participants (Who gets to be 100?) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A series of three podcasts, available for wide dissemination on Achor and other platforms, including Spotify and Apple Podcasts, celebrating the Lothian Birth Cohort 1921 and those who reached their 100th birthday in 2021, their contribution to science and our understanding of what happens to our thinking skills as we grow older. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.ed.ac.uk/lothian-birth-cohorts/public-engagement/who-gets-to-be-100-the-podcast |
| Description | Is learning languages good for your brain? - Thomas Bak |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Interactive invited talk about research on bilingualism and the brain at the "creative space", the Welcoming, Edinburgh. The session included drop-in activities in collaboration with Science Ceilidih and Leith Labs (in preparation for the Explorathon). |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.facebook.com/scienceceilidh/photos/a.1486421958282891/2187137418211338/?type=3 |
| Description | LBC Study Reunion |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | A study reunion with talks by team members and collaborators with research outcomes and future plans, and interviews with participants |
| Year(s) Of Engagement Activity | 2023 |
| Description | LBC Study at the Scottish Parliament (Neuroscience matters: Research for future health, organised by BNA) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Dr Simon Cox represented the LBC Study at the Scottish Parliament at Neuroscience Matters: Research for future health, organised by BNA |
| Year(s) Of Engagement Activity | 2023 |
| Description | Language learning and brain health - Thomas Bak |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Webinar presentation for the Open University (collaboration with Lingo flamingo tutor training programme). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Language learning as a cognitive intervention - Thomas Bak |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the "Languages and Cultural knowledge in global healthcare" organised by QUB-AHRC |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://pure.qub.ac.uk/portal/en/impacts/languages-and-cultural-knowledge-in-global-healthcare(b94c1... |
| Description | Learning a foreign language as a cognitive intervention in dementia - Thomas Bak |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk presented at the World Federation of Neurology, Viana do Castelo, Portugal. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.spneurologia.com/evento/wfn-aphasia-dementia-and-cognitive-disorders-bienn/332 |
| Description | Leith Labs - Alan Gow |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The Ageing Lab - Can taking up new activities improve the health and wellbeing of older adults? Workshop at Stay Sharp in Older Age hosted by Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) in association with Leith Labs (part of The MRC Festival of Medical Research), Edinburgh, UK, 17th June 2017. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Life as a geneticist - Harris |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A morning session talking to primary school children about life as a geneticist. The children made DNA models out of sweets and cocktail sticks (February 2016). |
| Year(s) Of Engagement Activity | 2016 |
| Description | Lifetimes event at Midlothian Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Discussion session about the history and current research relating to the Lothian Birth Cohorts, and a showing of the short film The Living Brainabout the Lothian Birth Cohorts. Followed by hands-on reaction time testing and demonstration of brain images/3D printouts. ~30 members of the public attended a talk and a Q and A session. A great deal of interest in the Lothian Birth Cohort studies and multiple Q andA sessions with a very engaged audience. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://midlothiansciencefestival.com/event/lifetimes/ |
| Description | Lothian Birth Cohort Study 1921 annual newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | The Lothian Birth Cohort Study 1921 has produced an annual newsletter since 2003. It was written to inform cohort study members of any main results from the study. The newsletter mailing list has a varied audience of lay and scientists. It summarises major achievements of the Centre and our recent news items. |
| Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016 |
| Description | Lothian Birth Cohort Study 1936 annual newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | The Lothian Birth Cohort Study 1936 produces and annual newsletter which is sent to a large mailing list of over 500 individuals. Most of those on the mailing list are study members of the LBC cohort. The newsletter lets them know of new results which their data has produced. It is sent out with the study Christmas card. |
| Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016 |
| Description | Lothian Birth Cohort reunion April 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | A reunion for participants in the Lothian Birth Cohorts of 1921 and 1936 was held on April 17th 2014 in Edinburgh. Presentations were given by main Principal Investigators and study co-ordinator on the results of the study to date, and short presentations were given on offshoot studies including the 6-Day Sample study and the MRC-funded Seniors USP study from which Dr Philippa Dall presented. There was also a premiere of the film "The Living Brain" made by Anne Milne. Participants enjoyed the day and were interested and engaged in the information presented. They were given the opportunity to ask questions towards the end of the day and a great range of questions were received and answered. Talks from the reunion are on YouTube http://youtu.be/v1v7mHGkkgI |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://youtu.be/v1v7mHGkkgI |
| Description | MRC Centenary celebrations - Dynamic Earth |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | CCACE had a stall at the Scottish MRC Centenary celebration held at Our Dynamic Earth on 19th November 2013. Awareness of the work of the Centre was raised amongst attendees, who were largely other MRC-funded researchers. |
| Year(s) Of Engagement Activity | 2013 |