Centre for Cognitive Ageing & Cognitive Epidemiology

Lead Research Organisation: University of Edinburgh
Department Name: Centre Cogn Ageing and Cogn Epidemiology

Abstract

In 2008 we formed the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) at the University of Edinburgh. This brought together a diverse range of scientists-epidemiologists, psychologists, geriatricians, clinical and basic neuroscientists, geneticists, statisticians, sociologists-to study how the brain and the body influence each other across the human life course and between generations. This application describes how CCACE enhanced this important research, and our plans for the next five years.

The Centre brought a step change in our scientific achievements, our training of young scientists, and the communication of our research to wider, non-scientific groups. In science, we made achievements in four areas. (1) Our discoveries made us the leading international centre for the study of how intelligence from youth influences physical health, wellbeing, mental illness and mortality later in life (cognitive epidemiology). (2) In our large groups of older people on whom there were measures of intelligence from youth we made discoveries about genetic, lifestyle, brain structure and other contributions to the ageing of thinking (cognitive) skills that put us at the forefront internationally. Our discoveries on how diabetes affects thinking skills are based on one of the largest studies. (3) Our work uses theories of how the brain works to explore ageing effects on important specific thinking skills. This led to our devising tests for the early detection of dementia. (4) Our scientists working on the biological mechanisms of cognitive decline have made discoveries in human and animal studies that revealed likely biological routes for the amelioration of cognitive ageing. The Centre's presence brought new collaborators, gave us the capability to lead new cohorts and international consortia, and brought in a new Alzheimer Research Centre.

The Centre brought a step change in the training of young scientists. The thriving mix of successful scientists working together has built up a community of PhD students concentrating on our aims. Many who are not funded by the Centre have come under our umbrella, adding value. We are meeting a need for the training of clinical scientists in our areas. The Centre has also been responsible for a step change in knowledge exchange. Our work with lay people, policy makers, artists, and business has brought our science out of the office and laboratory, creating awareness, new art, and products, and influencing policy.

In the next five years the University of Edinburgh is generously supporting the Centre by funding a substantial amount of what originally came from LLHW funding. In research training, our vision is to mentor young scientists from the end of their PhDs and helpi them to develop into independent scientists in cognitive ageing and cognitive epidemiology to meet these important needs. In our four research Groups' fields we highlight the key areas in which we aim to make discoveries. Here, we mention a few. We are expanding our cognitive epidemiology work to examine how personality and thinking skills affect later health and illness. We shall conduct large-scale new genetic work in our cohorts of older people to find out how people's environments affect how their genes switch on and off and thereby affect thinking skills and other aspects of ageing. We shall conduct unusually large longitudinal studies to examine the parallel changes in brain scans and thinking skills, and the changes in cognition over 10 years in people with type 2 diabetes. We shall delve into specific thinking processes to find the precise sets of problems that best characterise various forms of normal and illness-based cognitive ageing. We shall undertake parallel human and animal work to investigate the importance and nature of changes in small blood vessels for brain health and thinking skills. We have an ambitious strategy for an expanded and more formalised programme of knowledge exchange.

Technical Summary

The Centre will: (1) elucidate the routes to the vulnerable ageing brain; (2) find mechanisms by which lower cognitive ability makes the body vulnerable to ill health; (3) provide an outstanding environment for interdisciplinary research training.

In research training:
Mentor a new cohort of post-doctoral scientists.
Expand our cohort of interdisciplinary PhD students.
Expand our training of medical scientists.

In cognitive epidemiology:
Expand it to include non-cognitive traits.
Conduct individual participant meta-analyses.
Use new datasets to test mechanistic hypotheses.

In cohort work on cognitive ageing:
Expand work on the Lothian Birth Cohorts and Edinburgh type 2 Diabetes Study.
Test genetic and environmental influences on cognitive change from childhood to old age and in old age.
Test determinants of cognitive change across 10 years in type 2 diabetes.
Conduct longitudinal genome-wide methylation studies.
Conduct genome-wide expression studies.
Test associations between the human brain connectome and cognitive functions.
Lead international consortia on GWAS, exome chip, and methylation studies of cognition, novel brain imaging and other phenotypes.

In experimental work on cognitive ageing:
Complete regulatory approval for Alzheimer diagnostic tests.
Use brain imaging to explore why some cognitive functions are preserved with age.
Identify cognitive signatures that identify those likely to convert to dementia.
Explore the relationship between the design and use of digital memory systems and our research on age-impaired forgetting and multitasking.

In mechanisms of cognitive ageing:
Investigate how stress and glucocorticoids influence cognitive ageing and test therapeutic strategies.
In cerebral small vessel disease test the importance of vascular integrity, inflammation and oxidative stress for ageing brain integrity.
Understand how brain injury occurring in the context of acute systemic illness can alter cognitive decline.

Planned Impact

We described above that a wide range of academics benefit from our research. Our research on the determinants of cognitive ageing and the factors that promote bodily health through life are of very wide public and professional interest. The non-academic beneficiaries of this work will be older people, care providers, the wider general public, public health providers, policy makers, third sector organisations, and business. Of those organisations mentioned in the guidance notes, our work already appears in Science Museums in London and Glasgow and we are in regular contact with the charity Age Uk with whom we have a joint Knowledge Exchange programme.

Our research, coupled with our knowledge exchange strategy, will enable older people to understand what happens to cognitive abilities with increasing age, learn which potentially preventable factors affect brain health and cognitive function, benefit from more accurate diagnosis of Alzheimer's disease or delirium, and, for example, from information about ways to compensate for some of the effects of dementia by not undertaking certain forms of dual tasking. Our research will also benefit those who care for people with dementia; for instance, advice about the difficulties such patients have with carrying out more than one mental task simultaneously.

As regards public health providers, our research has the potential to lead to interventions to ameliorate age-related cognitive decline and provide clinical benefits through the development of methods for more accurate diagnosis of dementia or delirium. For third sector organisations, our research will provide benefits in terms of the advice and support they can offer to older people who are concerned about cognitive ageing and brain health. We have already provided this to Age UK for its widely-distributed book on Ageing Well.

CCACE members and core staff have a strong track record of engagement with policy makers. Our research will provide benefits to policy audiences at a national (UK and Scottish) government level and also NHS and local councils. This has and will continue to be in the form of research evidence about the effects of cognitive ageing, the importance of maintaining brain health, the life-long nature of ageing, earlier and accurate diagnosis of dementia (or otherwise), and ways in which cognitive decline might be ameliorated or delayed-all of crucial importance at a time of rapid population ageing. The commercial sector will benefit from our research because it involves the development of diagnostic tools as well as, for instance, guidelines for the care of individuals by private care organisations. All these beneficiaries are likely to benefit from our research within 1 to 5 years.

Our work with artists has benefited both that community and also the people who have come to see the science-art projects we have engaged in. Artist Linda Fleming produced an exhibition (shown at InSpace in Edinburgh and Hancock Gallery in Newcastle) that explored the association between cognitive and bodily health in the Lothian Birth Cohort 1936. We currently have renowned portrait artist Fionna Carlisle creating portraits of scientists and participants in our ageing cohorts to explore ageing. We have writer Ann Lingard creating life narratives of the scientists and participants of our Lothian Birth Cohorts. We have hosted and created three theatre productions to explore cognitive ageing. We have two grant applications in for more science-art projects. We plan more high-quality artistic joint projects to achieve awareness of our research issues.

For staff and research students working in the Centre, we ensure that they have multidisciplinary training. This makes them especially well prepared for an independent research career. They benefit from working in an area of such growing public importance, and in a Centre which works hard to create the best and widest awareness and understanding of our research.

Organisations

Publications

10 25 50
 
Title Brain Box 
Description Brain Box is a portable workshop/festival resource to excite children and adults about the brain, how it works and the changes it goes through in a lifetime. It is a resource for guided workshops, festivals, exhibitions and events that would over time develop an online "personality" tweeting about its day with photo's, comments and quotes: see me on Twitter @brainboxone 
Type Of Art Artefact (including digital) 
Year Produced 2014 
Impact To date, the Brain Box has received funding from the MRC Regional Communications Fund and, despite still being at the development stage, is planned to appear at workshops as part of the Edinburgh International Science Festival 14-18 April 2015. 
URL http://www.twitter.com/brainboxone
 
Title Brain Training on Trial 
Description An hour-long show developed for the Edinburgh Festival Fringe 2014, involving audience participation and presentation of research on the usefulness of brain training. The show took the form of a 'trial' in which the audience was the jury and co-presenter the judge. 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2014 
Impact The trailer for the show was uploaded to You Tube and has been viewed 534 times as at 7th November 2014 (http://www.youtube.com/watch?feature=player_embedded&v=9g2puKGaE-E). The post-event summing up video has also been uploaded to You Tube on 20th October 2014 and has been viewed 70 times (http://www.youtube.com/watch?v=fROGW49Z81Q). A blog post was also written summarising the evidence for and against brain training. 
URL http://researchtheheadlines.org/2014/09/09/brain-training-on-trial/
 
Title Fashion design final year show - Russ 
Description This CCACE member met with a fourth year student at Heriot Watt University studying Fashion Design who chose to base her final collection design concept around dementia. They discussed the science of dementia and its investigation. She subsequently developed the designs into scarves which she sold in aid of Alzheimer Scotland. 
Type Of Art Artefact (including digital) 
Year Produced 2016 
Impact The design student developed the designs into scarves which she sold in aid of Alzheimer Scotland. She is now developing the designs for a range with the high street retailer H&M. 
URL https://www.nadiapinkney.com/remember-me-knot
 
Title LBC1936 Fast Facts Card 
Description Dr Simon Cox and Professor Ian Deary designed a 'Lothian Birth Cohort 1936 Fast Facts Card' - a 12 facet credit-card sized concertina leaflet containing information about the LBC1936 study for distribution to the general public at future KE events, interested academics / potential collaborators, LBC members etc. 
Type Of Art Artefact (including digital) 
Year Produced 2014 
Impact This has been distributed to interested academics and potential collaborators and will be distributed to participants in the Lothian Birth Cohort 1936. Age Scotland have requested 150 and an initial print run consisted of 2000 copies. 
 
Title Lifetimes book - Ann Lingard 
Description CCACE collaborated with a local author, Ann Lingard, to create a short book entitled 'Lifetimes - personal stories from the Lothian Birth Cohorts'. Ann interviewed several participants in both Lothian Birth Cohorts 1921 and 1936 and several members of staff, including the Centre director, creating this short collection of life stories. It has been professionally typeset with an attractive cover and introduction by CCACE/LBC director Ian Deary. It is heavily illustrated with photographs reflecting the life courses of the participants and scientists in the Lothian Birth Cohort studies. 
Type Of Art Creative Writing 
Year Produced 2014 
Impact The book has been sent to all CCACE collaborators and contacts, as well as being given out to participants at the Lothian Birth Cohort reunion in April 2014. It has been available to download as an e-book on various websites for many months. About 2000 physical copies of the book have been printed. It is free on iTunes, and there is a nominal cost (77p) on Amazon for a Kindle edition. 
URL https://itunes.apple.com/gb/book/lifetimes/id893954634?mt=11
 
Title Portraits - Fionna Carlisle 
Description CCACE has been collaborating with a local artist, Fionna Carlisle, who has painted portraits of the Centre director, Ian Deary, several of the Centre's staff, and a number of participants from the Lothian Birth Cohort studies. She is aiming to complete a collection of over 20 portraits of participants and scientists. 
Type Of Art Artwork 
Year Produced 2014 
Impact The artwork has been displayed at a number of prestigious local and national events, including as part of an exhibition at the British Library in London entitled Portraying Ageing on 28th April 2014, and at local events associated with the MRC Centenary. The CCACE knowledge exchange officer and Fionna Carlisle, along with Centre director Ian Deary, are in discussion with local art galleries and museums with regard to a full-scale exhibition of these portraits and the scientific programme of work which lies behind them. 
URL http://www.fionnacarlisle.com/
 
Title The Great British Brain Off - Alan Gow 
Description The Great British Brain Off. Show at the Edinburgh Festival Fringe as part of Edinburgh Beltane's Cabaret of Dangerous Ideas, Edinburgh, UK, 27th August 2015. Performance, associated trailer, and follow-up video: https://www.youtube.com/watch?v=X20p9oCYI8Y https://www.youtube.com/watch?v=yZF76K1hKDk 
Type Of Art Performance (Music, Dance, Drama, etc) 
Year Produced 2015 
Impact Raise the profile of cognitive ageing research. 
 
Title The Living Brain short film - Anne Milne 
Description CCACE collaborated with film maker Anne Milne to produce a short film describing the Lothian Birth Cohort 1921 and 1936 studies and charting the life course and current circumstances of one participant from each study. The film was premiered at the Lothian Birth Cohort reunion in April 2014 and has since been screened a number of times, including at the CCACE Annual Research Day in August 2014 and Midlothian Science Festival in October 2014. 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact The film has been screened a number of times, both to research participants, collaborators and other academics, and members of the public attending a science festival talk. It has now been seen by, we estimate, many hundreds of people and Anne Milne has plans to submit it to film festivals and science festivals. The film is listed on www.imdb.com. 
URL http://www.imdb.com/name/nm3596775/
 
Description ALLEA UK representative - Pickersgill
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
URL http://www.allea.org/Pages/ALL/4/731.bGFuZz1FTkc.html
 
Description Age UK/AARP Global Council on Brain Health expert meeting (Gow)
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact The Global Council on Brain Health convenes experts who then produce reports on factors affecting cognitive and brain function. These are widely distributed so that people's knowledge and actions (e.g. lifestyle changes) are based upon the best available empirical evidence. This is done in part via Age UK, the largest UK ageing charity with a very wide reach to older people in the UK and internationally.
URL http://www.ageuk.org.uk/professional-resources-home/research/about-age-uk-research/the-global-counci...
 
Description Assigned Chair of SIGN Guidelines Committee on delirium - MacLullich
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
URL http://www.sign.ac.uk/pdf/Delirium_KQs_v0%203_consultation.pdf
 
Description BBSRC Bioscience for Society Strategy Panel - Pickersgill
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Citizens Jury report on Guthrie spots - David Porteous
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description European Commission, Directorate General Education and Culture, Thematic Panel on Languages & Literacy
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Informed the Government on educational changes.
 
Description Forum "Influencing the trajectories of ageing" - Ian Deary
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact The Academy of Medical Science brought together international experts on the influences on human and other animal ageing systems. These were presented in a forum conducted under Chatham House rules. There was an invited audience of about 60 experts in total. Each of the presentations-including Ian Deary's-was summarised and compiled in a report that was made available as an online PDF, communicated to the news media, and is intended to influence policy makers on the important issue of how to optimise the trajectories of human health across the full life course.
URL https://acmedsci.ac.uk/more/news/trajectories-of-ageing-balancing-longevity-and-health
 
Description Global Council on Brain Health - Alan Gow
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Global Council on Brain Health (2017). "The Brain and Social Connectedness: GCBH Recommendations on Social Engagement and Brain Health."
URL http://www.GlobalCouncilOnBrainHealth.org
 
Description Global young leader in dementia - Russ
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact I was recommended by the MRC and selected as one of Europe's young leaders in dementia by the World Dementia Council. I attended the European event in London to identify innovative ideas to address dementia following the G8 Summit & World Council on Dementia. The priorities for dementia research and care which the global young leaders drafted at a number of international meetings were presented to the World Council on Dementia in 2015.
URL http://www.neurodegenerationresearch.eu/2015/03/young-leaders-from-across-europe-join-global-search-...
 
Description Government Office for Science "Evidence and Options for Preserving Cognition Through Life" - Ian Deary
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL http://www.ccace.ed.ac.uk/node/336
 
Description Influencing national health indicator - Russ
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact My work on psychological distress (e.g. Russ et al., 2012) has been used to recommend the introduction of a new indicator by the Department of Health: "Excess under 75 mortality rate in adults with common mental illness" (Indicator 1.5 ii in the NHS Outcomes Framework 2015/16).
URL http://www.gov.uk/government/publications/nhs-outcomes-framework-2015-to-2016
 
Description MRC review of UK population studies - LBC
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.mrc.ac.uk/news-events/publications/maximising-the-value-of-uk-population-cohorts/
 
Description Northern Ireland Department for Communities, Irish Language Academy, Belfast
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact Informed the public of educational changes.
 
Description RSE Young Academy of Scotland - Alan Gow
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description RSE Young Academy of Scotland - Martyn Pickersgill
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Science and Trust Parliamentary Links Day - Pickersgill
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Scottish Dementia Clinical Research Network - John Starr
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Scottish Government Data Linkage Framework - Deary
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Scottish Public Health Network (Johnson)
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description ADRC - Scotland, ESRC
Amount £7,930,752 (GBP)
Funding ID ES/L007487/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 11/2013 
End 10/2018
 
Description AHRC-OWRI Multilingualism: Empowering Individuals, Transforming Societies (MEITS)
Amount £419,496 (GBP)
Funding ID RG78116 
Organisation Arts & Humanities Research Council (AHRC) 
Sector Public
Country United Kingdom
Start 07/2016 
End 06/2020
 
Description Age UK - The Disconnected Mind, Phase 3
Amount £1,317,193 (GBP)
Organisation Age UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description Alzheimer Scotland Dementia Reseach Centre renewal funding (CCACE sister Centre) - John Starr
Amount £750,000 (GBP)
Organisation Alzheimer Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Alzheimer Scotland: Marjorie MacBeath bequest - Russ
Amount £100,000 (GBP)
Funding ID R44120 
Organisation Alzheimer Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2015 
End 08/2016
 
Description Alzheimer's Research UK Major Project Grant
Amount £166,833 (GBP)
Funding ID ARUK-PG2017B-10 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Alzheimer's Society - Fergus Doubal
Amount £245,385 (GBP)
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 09/2017
 
Description British Academy - Alan Gow
Amount £14,939 (GBP)
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 03/2015 
End 03/2016
 
Description CSO Cerebrovascular reactivity - Wardlaw Doubal Marshall
Amount £137,420 (GBP)
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 02/2014 
End 07/2015
 
Description Chest Heart Stroke Scotland - Wardlaw
Amount £75,815 (GBP)
Organisation Chest Heart & Stroke Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2014 
End 01/2016
 
Description Clinical Fellowship - Russ
Amount £100,000 (GBP)
Funding ID R44120 
Organisation Alzheimer Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2015 
End 08/2016
 
Description Colciencias, Colombia. Emergent Social and Health Challenges
Amount £16,000 (GBP)
Organisation Administrative Department of Science, Technology and Innovation (Colciencias) 
Sector Public
Country Colombia
Start 07/2016 
End 12/2016
 
Description Conference travel funding - Alan Gow
Amount £950 (GBP)
Organisation Royal Society of Edinburgh (RSE) 
Sector Learned Society
Country United Kingdom
Start 04/2016 
End 04/2016
 
Description Confidence in Global Mental Health Research 2017
Amount £188,567 (GBP)
Funding ID MR/R01910X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description Doctoral Training Programme - Karen Horsburgh
Amount £346,000 (GBP)
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 08/2018
 
Description Dunhill Medical Trust - Alan Gow
Amount £74,700 (GBP)
Funding ID R359/0514 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 05/2016
 
Description Dunhill Medical Trust - Tablet for Healthy Ageing (Gow)
Amount £74,700 (GBP)
Funding ID R359/0514 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2014 
End 04/2016
 
Description EPSRC Multi-modal retinal biomarkers - Wardlaw Doubal Deary
Amount £1,100,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 03/2018
 
Description EPSRC: retinal biomarkers
Amount £1,153,990 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2015 
End 01/2018
 
Description ESRC Project Grant - Working memory across the adult lifespan: An adversarial collaboration (Logie)
Amount £1,154,370 (GBP)
Funding ID ES/N010728/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2020
 
Description ESRC: Epigenetics
Amount £667,456 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description EU Joint Programme - neurodegeneration (Wardlaw)
Amount € 47,416 (EUR)
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND) 
Sector Public
Country European Union (EU)
Start 10/2014 
End 03/2015
 
Description Edinburgh Lothians Health Foundation BraINS - Shenkin Wardlaw Job
Amount £38,810 (GBP)
Organisation Edinburgh & Lothians Health Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2014 
End 03/2015
 
Description FAPESP-HWU Scheme 2016 (Brazil - Heriot-Watt University)
Amount £40,000 (GBP)
Organisation São Paulo Research Foundation (FAPESP) 
Sector Public
Country Brazil
Start 08/2016 
End 08/2018
 
Description Gow Hagger-Johnson - Research visitors to Scotland
Amount £300 (GBP)
Organisation Royal Society of Edinburgh (RSE) 
Sector Learned Society
Country United Kingdom
Start 04/2014 
End 05/2014
 
Description Guest Professor programme - Alan Gow
Amount £3,325 (GBP)
Organisation University of Copenhagen 
Sector Academic/University
Country Denmark
Start 11/2015 
End 12/2015
 
Description Guest professor - Alan Gow 2013
Amount £22,500 (GBP)
Organisation Nordea Foundation 
Sector Charity/Non Profit
Country Denmark
Start 05/2013 
End 07/2013
 
Description Guest professor - Alan Gow 2014
Amount £20,000 (GBP)
Organisation Nordea Foundation 
Sector Charity/Non Profit
Country Denmark
Start 11/2014 
End 12/2014
 
Description Harris pilot study award - Generation Scotland
Amount £8,800 (GBP)
Organisation University of Edinburgh 
Department MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Sector Public
Country United Kingdom
Start 04/2014 
End 06/2014
 
Description Heriot-Watt Principal's Public Engagement Award (Gow)
Amount £1,000 (GBP)
Organisation Heriot-Watt University 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 06/2016
 
Description How do peripheral and central vascular markers relate to cognitive decline? - Deary
Amount £91,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2015 
End 01/2017
 
Description INTERpreting epigenetic signatires in Studies of Early Life Adversity (interSTELA) - Deary
Amount £199,512 (GBP)
Funding ID ES/N000382/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2015 
End 08/2017
 
Description Junior Investigator Pilot Award - Zoe Tieges
Amount $49,871 (USD)
Organisation Nidus Partners LP 
Start 04/2018 
End 10/2018
 
Description LACunar Intervention Trial - Fergus Doubal
Amount £847,771 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 02/2019
 
Description Leverhulme Trust Research Grant
Amount £106,031 (GBP)
Funding ID RPG-2013-066 
Organisation The Leverhulme Trust 
Sector Academic/University
Country United Kingdom
Start 11/2013 
End 10/2015
 
Description MRC Confidence in Global Mental Health Research Grant
Amount £196,755 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description MRC Integrated dementia research environment
Amount £6,825,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2015 
End 03/2016
 
Description MRC UK Dementia Platform
Amount £5,639,037 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description MRC travel grant - Kathryn Walesby
Amount £1,800 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC: LBC1936 III
Amount £1,316,451 (GBP)
Funding ID MR/M013111/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2015 
End 02/2019
 
Description Moray Endowment Fund (Pickersgill) - animal models and dynamics of biomedicine
Amount £963 (GBP)
Organisation University of Edinburgh 
Department Moray Endowment Fund
Sector Academic/University
Country United Kingdom
Start 01/2013 
End 12/2013
 
Description NIA - Human structural connectome
Amount $2,384,683 (USD)
Funding ID R01AG054628 
Organisation National Institute on Aging 
Sector Public
Country United States
Start 07/2017 
End 06/2022
 
Description Nioi et al Blue light exposure and sleep
Amount £8,164 (GBP)
Organisation Government of Scotland 
Sector Public
Country United Kingdom
Start 01/2014 
End 12/2014
 
Description PhD studentship - Horsburgh
Amount £85,000 (GBP)
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 08/2019
 
Description PhD studentship - Karen Horsburgh
Amount £99,228 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 08/2018
 
Description Pickersgill - visiting scholar, Wisconsin-Madison
Amount £932 (GBP)
Organisation Royal Society of Edinburgh (RSE) 
Sector Learned Society
Country United Kingdom
Start 03/2014 
End 04/2014
 
Description Postdoctoral Fellowship
Amount £148,126 (GBP)
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 03/2020
 
Description Project grant - Horsburgh
Amount £561,607 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Project grant - Horsburgh
Amount £326,594 (GBP)
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Project grant - JPND (Deary)
Amount £592,325 (GBP)
Funding ID MR/N027558/1 
Organisation Medical Research Council (MRC) 
Department MRC Human Nutrition Research Unit
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2019
 
Description Project grant - MacLullich
Amount £185,751 (GBP)
Funding ID R484/0516 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2020
 
Description Project grant - MacLullich
Amount £260,000 (GBP)
Funding ID ARUK-PG2016B-12 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 10/2018
 
Description Project grant - The Intervention Factory (Gow)
Amount £343,728 (GBP)
Organisation Velux Foundations 
Sector Charity/Non Profit
Country Denmark
Start 07/2016 
End 06/2019
 
Description Research and Development Grant Scheme (Harrison)
Amount £25,000 (GBP)
Funding ID Ref 854 
Organisation Edinburgh & Lothians Health Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2016 
End 12/2017
 
Description Researcher Links, British Council - Aribisala / Gow
Amount £4,320 (GBP)
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 10/2014
 
Description Rewrite the Headlines: Follow-up funding (Gow)
Amount £5,000 (GBP)
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2017
 
Description SFC SINAPSE Network development - Wardlaw et al
Amount £325,000 (GBP)
Organisation Government of Scotland 
Department Scottish Funding Council
Sector Public
Country United Kingdom
Start 10/2014 
End 09/2019
 
Description Scottish Government - Alan Gow
Amount £8,164 (GBP)
Organisation Government of Scotland 
Sector Public
Country United Kingdom
Start 01/2014 
End 03/2017
 
Description Seniors USP - LLHW
Amount £992,001 (GBP)
Organisation Medical Research Council (MRC) 
Department Lifelong Health and Wellbeing (LLHW)
Sector Public
Country United Kingdom
Start 05/2014 
End 04/2017
 
Description Starter grant for clinical lecturers - Russ
Amount £30,000 (GBP)
Funding ID R43610 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2015 
End 08/2016
 
Description Starter grant for clinical lecturers - Russ
Amount £30,000 (GBP)
Funding ID R43610 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2015 
End 08/2016
 
Description Strathclyde University PhD Studentship Research Excellence Award for Health (Gow)
Amount £58,060 (GBP)
Organisation University of Strathclyde 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 08/2020
 
Description Stroke Association - Fergus Doubal
Amount £234,989 (GBP)
Funding ID TSA15LECT04 
Organisation Stroke Association 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2015 
End 05/2020
 
Description The Intervention Factory: PhD Studentship - Alan Gow
Amount £63,396 (GBP)
Organisation Velux Foundations 
Sector Charity/Non Profit
Country Denmark
Start 09/2017 
End 08/2020
 
Description Travel award - Russ
Amount £1,000 (GBP)
Organisation Alzheimer Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2016 
End 08/2016
 
Description Travel award - Russ
Amount £5,405 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 08/2016
 
Description Travel award - Tieges
Amount £800 (GBP)
Organisation Guarantors of Brain 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2016 
End 06/2016
 
Description Travel grant - Russ
Amount £5,405 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 08/2016
 
Description UofE Sparking Impact scheme - Shenkin Wardlaw
Amount £19,417 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 03/2014 
End 08/2014
 
Description WT: MRI
Amount £600,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2019
 
Description WT: Stratifying depression
Amount £4,591,695 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2020
 
Description Wellcome Trust MRI lifecourse influences - Wardlaw
Amount £600,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2019
 
Description Wellcome Trust STRADL award
Amount £4,750,000 (GBP)
Funding ID 104036/Z/14/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2019
 
Description Wellcome Trust Society and Ethics Small Grant
Amount £3,500 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2014 
End 06/2015
 
Title 3D brain 
Description A 3D Brain based on MRI Scans has been developed. This Brain is true 3D in cyberspace and can be viewed and projected in anaglyph 3D and well as a higher quality rendition using a fast shuttered glasses system from Nvidia. Two Brains are available for viewing at the moment , a healthy young and a healthy old brain. The 3D brain can be rotated and zoomed in real time to allow the demonstration of anatomical features on the reconstructed models. The tools developed are capable of importing any 3D model and future developments may include tractography etc. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2013 
Provided To Others? Yes  
Impact This system was used as a demonstrator at the opening of CRIC by HRH Duke of Edinburgh. In 2011 it was demonstrated at the Edinburgh International Science Festival that attracted ~3000 visitors, at the Glasgow Science Centre, and has been taken around schools by CCACE employee Jack Nissan. In 2014 the 3D brain was demonstrated at the Edinburgh Neuroscience Day (March 12th 2014) and at a reception held by Age UK at St James's Palace and hosted by HRH Prince Charles (Jan 28th 2014). 
 
Title 4-A's Test for Delirium - Alasdair MacLullich 
Description Development of a new clinical screening for delirium called the '4 A's Test' or the '4AT' for short. This was done initially in collaboration with Dr Tracy Ryan, Dr Helen Cash and Dr Susan Shenkin. The development programme now involves collaborations with several units, including: Professor Bree Johnston, University of California at San Francisco; Dr Duncan Forsyth, Addenbrooke's Hospital, Cambridge; and Professor John Young (Chair of the NICE guidelines committee for delirium), University of Leeds. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Tool is in use in Lothian NHS currently in five pilot areas; will be in general use in medical areas within the next few months. The 4AT, though designed for clinical use, can be used in clinical research. Since 2011 has been made available for free download on a website that Professor A MacLullich set up: www.the4AT.com 
URL http://www.the4AT.com
 
Title Brain Observer Microbleeds Scale (BOMBS) 
Description If the diagnostic and prognostic significance of brain microbleeds are to be investigated and used for these purposes in clinical practice, observer variation in BMB assessments must be minimised. This scale takes into account the main sources of inter-rater disagreement in rating microbleeds seen in brain imaging, especially in older people. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2009 
Provided To Others? Yes  
Impact This has been published in the journal Stroke and made available to international researchers. This provides a new, well-validated scale for an important aspect of often-ignored brain pathology to be assessed in the older brain. Cordonnier, C., et al (2009) . Improving interrater agreement about brain microbleeds: Development of the brain observer microbleed scale (BOMBS). Stroke, 40, 94-99. 
URL http://www.sbirc.ed.ac.uk/research/imageanalysis.html#bombs
 
Title CCACE - LBC Lifetimes website 
Description The professional writer Ann Lingard composed stories of the lives of members of the Lothian Birth Cohorts of 1921 and 1936 and some of the wscientists working on the research. Each life was "told" as a small online facsimilie book with pictures across the lifecourse of each person. The individual books are professional looking and they have been gathered on to a website. The CCACE Systems Analyst worked closely with the CCACE Knowledge Exchange Officer to develop a new website for a large CCACE arts project called LBC Lifetimes. The project was set up to create stories of the lives and lifetimes of some of the participants and scientists involved in the LBC1936 study. The site has been viewed over 2300 times. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact The stories are available internationally for those wishing to learn more about the personal backgrounds of participants and esearchers in the Lothian Birth Cohort studies. 
URL http://www.lbclifetimes.org
 
Title CCACE hardware implementation - Dave Liewald 
Description The CCACE database manager, Mr Dave Liewald, has developed hardware within the group to support the research activities of CCACE research groups to aid with the collection and analysis of genotypic and phenotypic datasets for CCACE members as well as the daily functions of these groups. To this end a number of individual workstations and laptops, were built and implemented as well as a server cluster to support the large data volumes and concurrent processing needs. In summary, 9 workstations and 6 laptops have been installed which include 6 high performance analysis workstations for the manipulation and analysis of genetic data. A server cluster has been developed which has a number of functions covering the collection, assimilation analysis and distribution of data within the local group and globally with consortia and partners across the world including groups in Australia and the US. The cluster comprises of a number of machines each with specific functions and capabilities. 
Type Of Material Improvements to research infrastructure 
Year Produced 2012 
Provided To Others? Yes  
Impact The new hardware infrastructure has greatly eased the collection and analysis of large scale data for CCACE members to make research more effective. The hardware and software developments are currently being planned for extension, and generalisation for the use of the others via a BBSRC databases grant. 
 
Title CCACE websites and web applications - Dave Liewald 
Description The CCACE database manager, Mr Dave Liewald, has developed a number of websites for both internal and associated groups which are being hosted on the CCACE server cluster. These sites serve to collect and disseminate information to the groups and general public. These sites are: 1. CCACE Website 2. Disconnected Mind Website 3. Lothian Birth Cohort Website 4. Lothian Birth Cohort Infoserve : Intraweb for Statistical Genetic Group 5. EMCAGS : Edinburgh Manchester GWAS support Site 6. Sir Godfrey Hilton Thomson Collection Website 7. Scottish Dementia Network Website A download service has also been created on the web server for distribution of large data files between groups. Web applications are either CGI or ISAPI web server extensions that are created for secure collection and dissemination of data across the web. These applications are created in Delphi using a specialist collection of objects known as intra web which create secure robust web applications which rely heavily on javascript and Ajax to function. Applications created by the CCACE database manager include: 1. Phenotype Data Browser 2. Candidate gene system 3. LBC-Visage : Photograph Browser 4. Participant register 5. Prototype Volunteer Management System 6. Brain Imaging Data Upload 7. Brain Imaging Diagnostic Recording 
Type Of Material Improvements to research infrastructure 
Year Produced 2008 
Provided To Others? Yes  
Impact The websites are the vehicle by which the Centre is making available its cognitive tests to other researchers. 
 
Title Cognitive Estimation Task - MacPherson 
Description This is a cognitive test used in the detection of dementia and cognitive ability. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2015 
Provided To Others? Yes  
Impact Provided to the Psychology Research Laboratory, IRCCS Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, Italy and an Italian version of the Cognitive Estimation task was devised (Scarpina et al., 2015; Neurological Sciences) 
URL https://www.era.lib.ed.ac.uk/handle/1842/8747
 
Title Cox - frontal lobe parcellation method 
Description Identified and developed a novel method for identifying frontal lobe sub-regions from gyral topography based on a synthesis of previous methods and data from cytoarchitecture and hodology. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2014 
Provided To Others? Yes  
Impact The method was published in Brain Structure and Function (Impact Factor: 7.84) and this paper has been made available with supporting documentation online in the Image Analysis Tool section of the Brain Imaging Research Centre website (http://www.bric.ed.ac.uk/research/imageanalysis.html). Other publications resulted from this method and are published Cortex and Intelligence. 
 
Title Data collection systems - Dave Liewald 
Description The CCACE database manager has developed two data collection systems. 1) Two web based data collection systems were developed for SBRIC. These collect measurements from scans either by direct entry of the uploading of excel spreadsheets. 2) Two web based IPIP50 collection systems were created an successfully used to collect data from the general public and Students prior to lectures. 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact Data using these systems is currently being collected and analysed for publication in scientific papers. 
 
Title Developing a non-invasive cognitive aid to diagnosis and follow up of Alzheimer's Disease - Robert Logie 
Description Led by CCACE group leader, Professor Robert Logie and in collaboration with a number of CCACE members a new research tool for diagnosing Alzheimer's Disease has been developed. Over 20 years of laboratory based scientific research, development of prototype software and initial clinical trials has led to a successful collabortion with Toshiba to develop the tool. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Collaboration commenced in October 2010. Planned output will be a proven prototype diagnostic aid that may be used in Primary Care and also for evaluation of the effectiveness of interventions in clinical trials. Interest expressed for inclusion in clinical trials of pharmaceutical interventions due to run in 2011. In 2012 the test was adopted by the NHS Medical Devices Unit for Greater Glasgow and Clyde to develop from the current research versions into versions that can be used in routine clinical settings by nurses and General Practitioners. Scottish Health Innovations Ltd. is currently collating the necessary documentation to apply for approval from the UK Medicines and Healthcare products Regulatory Agency for clinical use within the NHS and in healthcare across Europe. 
 
Title IST-3 trial thrombolysis 
Description Joanna Wardlaw has been involved in the third International Stroke Trial (IST-3), a randomised controlled trial of the benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 hours of acute ischaemic stroke. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Thrombolysis is now widely used in >80's for treatment of acute stroke, thanks to IST-3. 
 
Title Image analysis method - hippocampal shape modelling 
Description In collaboration with the Korean Advanced Institute for Science and Technology, we have developed a novel method for hippocampal shape modelling. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Cox SR*, Valdés Hernández MC*, Kim J, Royle NA, MacPherson SE, Ferguson KJ, Muñoz Maniega S, Anglaban D, Aribisala BS, Bastin ME, Park J, Starr JM, Deary IJ, MacLullich AJM, Wardlaw JM. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. Psychoneuroendocrinology, doi: 10.1016/j.psyneuen.2017.01.027. Kim J, Valdés Hernández MC, Royle NA, Park J. Hippocampal shape modelling based on a progressive template surface deformation and its verification. IEEE Trans Med Imaging 2015 Jun;34(6):1242-61 Valdés Hernández MC, Cox SR, Kim J, Royle NA, Muñoz Maniega S, Gow AJ, Anglaban D, Bastin ME, Park J, Starr JM, Wardlaw JM, Deary IJ. Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. Neurobiol Aging in press. 
URL http://ieeexplore.ieee.org/document/6990617/?reload=true
 
Title Image analysis methods - IXICO 
Description Wardlaw and colleagues have been involved in developing analysis method for older subjects with IXICO, a commercial imaging research group. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact A Technology Strategy Board grant has been applied for based on pilot work. 
 
Title Imputation work-flow system - Dave Liewald 
Description The CCACE database manager has created an imputation work-flow system that manages a multiprocessor system and data-flow to enable the imputation of GWAS data against both Hapmap2 and Hapmap3. 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact This system has successfully imputed a number of datasets that are now in use in a number of international consortia investigating cognitive ageing and decline. In 2011, these tools have allowed imputed datasets to be created from the raw GWAS analysis of 5 Cohorts. All of the GWAS results for the cohorts we hold are now available as raw, HAPII and HAPIII imputed datasets. This has allowed the LBC datasets to be submitted to approximately 30 major international multi-cohort studies covering a very wide range of analyses. 
 
Title Liewald - CCACE cluster 
Description The CCACE computer cluster has been designed to allow it to deal with large GWAS datasets held by CCACE such as 1000G, exome sequencing and also the Generation Scotland reference genome sets. In conjunction with this are new file handling and merging techniques and pipelines which had to be developed to allow researchers to access and utilise these huge data resources. 
Type Of Material Biological samples 
Provided To Others? No  
Impact We have the capability of conducting, securely, large scale genetic analyses for our team and of allowing access to collaborators internationally. 
 
Title Memory Binding Tasks - R Logie, M Parra, S Della Sala 
Description A battery of memory binding task which can be useful in the assessment of patients with Alzheimer's disease, Mild Cognitive Impairment and amnesia. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact This battery has been used in Scotland in new projects adopted by the Scottish Dementia Clinical Research Network. A number of publications have resulted from this cognitive task, and new international collaborations are being formed aimed at introducing this methodology in to clinically-orientated projects. At least five publications have resulted from it so far. 
 
Title New method of perivascular space segmentation on brain MRI 
Description MRC-funded imaging team on the LBC1936 developed a new method of perivascular space segmentation, which shows good concordance with neuroradiological assessments. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact Ballerini L, Lovreglio R, Valdés Hernández MC, Gonzalez-Castro V, Muñoz Maniega S, Pellegrini E, Bastin ME, Deary IJ, Wardlaw JM. Application of the ordered logit model to optimising Frangi filter parameters for segmentation of perivascular spaces. Procedia Comp Sci 2016 90:61-67. 
URL http://www.sciencedirect.com/science/article/pii/S1877050916311899
 
Title Observational Scale of Level of Alertness (OSLA) - Roanna Hall 
Description CCACE member Dr Roanna Hall developed a new assessment tool for level of alertness in delirium, named the Observational Scale of Level of Alertness (OSLA). It is in the early stages of development, and an abstract assessing its usefulness in assessing alertness in delirium in patients with acute hip fracture was accepted for poster presentation at the European Delirium Association conference in Amsterdam, 11-12 November 2010. A poster on the OSLA was presented at the American Delirium Society inaugural conference in Indianapolis in June 2011 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact The tool has gained interest from members of conferences, and it has been taken forward for further development. In 2011, Dr Hall and colleagues have been working towards validating and publishing the OSLA. This research tool assesses alertness in hospital inpatients. It fills a gap in the current literature and complements our new cognitive assessment (Edinburgh Delirium Test Boxes 1 and 2). The OSLA has been used several hundred times in our research studies and is being refined with the help of CCACE statistician Dr Mike Allerhand. The refined version of the OSLA is due to be used in new studies in Oslo and Ireland. 
 
Title OpenMx 1.0 - Tim Bates 
Description OpenMx is free and open source software for use with R that allows estimation of a wide variety of advanced multivariate statistical models. OpenMx consists of a library of functions and optimizers that allow you to quickly and flexibly define an SEM model and estimate parameters given observed data. 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact None to date as it was only recently released. 
 
Title Reference white matter tracts 
Description We created a set of images depicting the geometry of some of the main of white matter tracts to be used as reference in the segmentation of white matter tracts from diffusion MRI data with tractography methods. These tracts were made available online in two batches, on the 13/02/09 and the 21/08/09 as part of a tractography software package called TractoR (http://code.google.com/p/tractor/). More info about the tracts is in http://code.google.com/p/tractor/wiki/ReferenceTracts. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2009 
Provided To Others? Yes  
Impact Reference tracts for DTI tractography in elderly participants. 
URL http://code.google.com/p/tractor/
 
Title Shenkin - Training course in systematic reviews 
Description Developed course in systematic reviews and meta-analysis (attended by ~20 students and staff members 2011, 2012 and 2013, with similar number signed up for full day course Dec 2014), and online resource freely available with step-by-step guidance on performing systematic reviews and meta-analyses, and useful resources. http://tinyurl.com/sysrev (online Sep, 2011). Lectures also being used as part of the CARMMS course in CCACE, and MSc in neuroimaging for research. 
Type Of Material Improvements to research infrastructure 
Year Produced 2011 
Provided To Others? Yes  
Impact The course materials are being widely used across the UK. 
URL http://tinyurl.com/sysrev
 
Title Wardlaw - Imaging-related research tools 
Description Wardlaw's group continues to develop a large number of imaging-related research tools for visual assessment of images and computational quantitative measurements. These include methods for measuring white matter hyperintensities, brain mineral deposition, perivascular space enlargement, and brain shrinkage. Links to these tools are available through the Brain Research Imaging Centre website (www.sbirc.ed.ac.uk/research/imageanalysis.html). 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact Members of the neuroimaging group have been invited to speak about their materials in London, Austria, North America, and at majpr conferences such as the European Society of Magnetic Resonance in Medicine. 
URL http://www.sbirc.ed.ac.uk/research/imageanalysis.html
 
Title fastBAT - Hill 
Description As part of a collaboration with the University of Queensland we have developed a method, called fastBAT, for combining single nucleotide polymorphism data into a single statistic representing a gene or a group of genes. This allows us to examine the joint effect of multiple genetic variants which can be used as a biomarker for ageing and ageing phenotypes. 
Type Of Material Improvements to research infrastructure 
Year Produced 2015 
Provided To Others? Yes  
Impact Allow data quicker anlaysis. 
URL http://cnsgenomics.com/software/gcta/fastBAT.html
 
Title Brain Images of Normal Subjects (BRAINS) Imagebank 
Description The Brain Images of Normal Subjects (BRAINS) imagebank is an integrated repository project sponsored by the University of Edinburgh and the Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) collaborators. The purpose of BRAINS is to provide sharing and archiving of detailed normal human brain imaging and relevant phenotypic data, to create better estimates of the range of normal brain size and integrity across the life-course. The Lothian Birth Cohort 1921 and 1936 brain imaging data along with limited clinical data has been added to this resource. BRAINS is a living imagebank where new data will be added when available. Initially BRAINS will contain existing data from n=763 healthy volunteer subjects, range neonatal and 19-81 years of age, from projects in 3 centres. A further n=2119 subjects aged from prenatal to 90 years old with existing records from 15 other projects in Scotland are currently being collected, collated and quality control (QC) checked. Additional completed and ongoing studies of normal individuals will be uploaded as they become available. The data include several magnetic resonance imaging (MRI) sequences, including T1, T2, T2*, fluid attenuated inversion recovery (FLAIR), and Diffusion Tensor Imaging (DTI), in DICOM and NIfTI format, and a wide range of linked metadata, such as age, history, physiological measures (e.g. blood pressure), cognitive ability, and perinatal information (neonatal data). Data access is governed by a steering committee comprising the PIs of the contributing studies, experts in ethics, law and governance, and lay representatives. Applications for data access can be made online, and will be granted by the steering committee subject to the completion of a formal Data Access Agreement. http://www.brainsimagebank.ac.uk/ 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The initial publication which describes the resource was: "A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)" Dominic E Job, David A Dickie, David Rodriguez, Andrew Robson, Cyril Pernet, Mark Bastin, James P Boardman, Alison D Murray, Trevor Ahearn, Gordon D Waiter, Roger T Staff, Ian J Deary, Susan D Shenkin, Joanna M Wardlaw. NeuroImage. doi: 10.1016/j.neuroimage.2016.01.027 PMID: 26794641. We have developed seven age-specific atlases of T1 brain MRI from 25 to 92 years, which have been made available on the BRAINS website. Dickie, David Alexander; Job, Dominic E.; Rodriguez, David; Robson, Andrew; Danso, Samuel; Pernet, Cyril; Bastin, Mark E.; Deary, Ian J.; Shenkin, Susan D.; Wardlaw, Joanna M.. (2016). Brain Imaging of Normal Subjects (BRAINS) age-specific MRI atlases from young adults to the very elderly (v1.0), [dataset]. University of Edinburgh, Edinburgh Imaging, CCBS, BRAINS Imagebank. http://dx.doi.org/10.7488/ds/1369. 
URL http://www.brainsimagebank.ac.uk
 
Title Model sensitivity to missing data 
Description A new procedure of longitudinal model sensitivity analysis to missing data has been developed and is described in: Allerhand, M., Gale, C. R., Deary, I, J. (2014). The dynamic relationship between cognitive function and positive wellbeing in older people: a prospective study using the English Longitudinal Study of Ageing. Psychology and Aging. 29(2), 306-318. doi:10.1037/a0036551. 
Type Of Material Data handling & control 
Year Produced 2014 
Provided To Others? Yes  
Impact The procedure has been described in the following publication: Allerhand, M., Gale, C. R., Deary, I, J. (2014). The dynamic relationship between cognitive function and positive wellbeing in older people: a prospective study using the English Longitudinal Study of Ageing. Psychology and Aging. 29(2), 306-318. doi:10.1037/a0036551. 
 
Title Novel data analysis method - Mike Allerhand 
Description Novel data analysis method: Questionnaire item bias by continuous covariates. http://www.ccace.ed.ac.uk/research/allerhand 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? Yes  
Impact Providing a statistical service. 
URL http://www.ccace.ed.ac.uk/research/allerhand
 
Description "Computational approach towards the characterisation of global and subregional brain changes with ageing and on the presence of cerebrovascular and neurodegenerative diseases" 
Organisation Korea Advanced Institute of Science and Technology (KAIST)
Department Computer Science Department
Country Korea, Republic of 
Sector Academic/University 
PI Contribution BRIC and Computer Graphics and Visualisation Research Lab, Computer Science Department We provided the reference segmentations (i.e. binary masks) of all the brain structures to be analysed within the context of this project, and on a visit done to KAIST on March we tested the hippocampal model previously developed by KAIST on a wider representative sample and together with KAIST collaborators we improved it incorporating alternative deformation procedures, and developed and tested a pipeline to determine the anatomical deformation to analyse shape variation on subgroups of the sample provided through the calculation of regional variations. The results showed that there are specific areas in the hippocampi for which the deformation is the opposite within each subgroup pair, strongly suggesting that these areas are related to the cognitive/biological parameter evaluated (i.e. general cognition, information processing speed, hypertension, etc). The analysis of the deformation in relation to gender revealed negligible differences between males and females, suggesting that the patterns seen in the analysis of the rest of the biological and cognitive parameters were independent and not determined/influenced by gender differences. We are currently drafting two manuscripts with these results. During the visit, we also agreed on a follow-up plan that includes the generation of the mesh models for other brain structures and evaluated alternatives to pursue them.
Collaborator Contribution Korea Advanced Institute of Science and Technology (KAIST
Impact Up to date, we have obtained 2 grants: one small grant for visiting KAIST (£2,240) and the grant that funds this collaboration for 2 years (£35,143.93) and are writing 2 publications.
Start Year 2011
 
Description "Short-term memory binding: validity as a cognitive biomarker for Alzheimer's disease across cultures and nations" - funded by Alzheimer's Society 
Organisation Cayetano Heredia University
Country Peru 
Sector Academic/University 
PI Contribution We have provided the methodology to undertake this project. I have met Dr Nilton Custodio during the World Congress of Neurology, celebrated in Chile in 2015 and in the AAIC 2016 in Toronto. I have met the team via teleconferences during which we have been assembling the team that will support this study locally.
Collaborator Contribution The Peruvian Institute of Neuroscience runs a 3-year longitudinal study as part of the programme of the title. This involved assessing elderly people from Peru living in urban and rural areas and with different levels of education ad languages
Impact Data collection in progress. As part of the meeting held in Santiago in 2015 to which other experts of Latin American Country attended, including Prof. Ricardo Nitrini from Brazil, Prof. Francisco Lopera, from Colombia and Prof. Facundo Manes from Argenitina, we prepared a Policy Paper to raise awareness about challenges in Latin America countries. This paper is submitted for publication.
Start Year 2016
 
Description "Short-term memory binding: validity as a cognitive biomarker for Alzheimer's disease across cultures and nations" - funded by Alzheimer's Society 
Organisation Del Rosario University
Country Colombia 
Sector Academic/University 
PI Contribution We have provided the methodology to undertake this project. I have visited and trained at The Institute of Psychology, Universidad de Valle and have delivered talks to the professional community, undergraduate and postgraduate students. I have been involved in assembling the clinical and neuroimaging team that will support this study locally.
Collaborator Contribution The Institute of Psychology of the above University of is supporting a 3-year longitudinal study on MCI. This involves behavioural, EEG and MRI measures of cognitive decline in elderly people with MCI. In collaboration with the Foundation Valle del Lili, we have secured funding for a 3-year longitudinal study using fMRI to follow up patents with MCI.
Impact 1) Expanded the UK-Latin America Brain Connectivity Research Network (Heriot-Watt University - and HCN University of Edinburgh, UK - Cali, Colombia). 2) A new research agenda has been launched that comprises behavioural and neuroimaging study of MCI patients all funded by local institutions.
Start Year 2016
 
Description ActiveAge 
Organisation BusinessLab
Country United Kingdom 
Sector Private 
PI Contribution The CCACE scientific administrator, Dr Beverly Roberts, attend the 2009 ActiveAge summit in Newcastle to alert members to the existence of the Centre. On the strength of this the CCACE is now a member of this group which discusses ways to tackle issues such as wellbeing, community, work and mobility in elderly individuals.
Impact The CCACE is now a known research group within the ActiveAge group and the Centre is working towards establishing more formal collaborations with the network.
Start Year 2009
 
Description Age UK 
Organisation Age UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Age UK are the principal/major funders of The Disconnected Mind project, which is led by Ian Deary begin_of_the_skype_highlighting     end_of_the_skype_highlighting. The plan is for around £11 million funding from 2008-2013. The CCACE knowledge transfer officer, Dr Robin Morton, has developed links with Age UK. Robin Morton met with Charlotte Potter, Programme manager - Public Services, Age Concern and Help the Aged this year to discuss the Centre's possible involvement in contributing to documents and events held by Age UK.
Impact Two years of The Disconencted Mind project have already been completed successfully with many publications. Age UK continue to advertise The Disconnected Mind on their website and paper communications with their many members and the public at large. This has a very successful funding and knowledge transfer activity bundled into one. Relevant publications: 18317464 19844571 19418213 18493267 19398500 18946731 19290744 19077176 19821022
Start Year 2009
 
Description Air pollution exposure - Russ 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Two projects are being undertaken with the Swedish team. 1. "Are epigenetic changes associated with air pollution exposure in the SATSA cohort?" 2016 - Karolinska Institutet, Sweden. Contributions: This work is at a preliminary stage but we are cleaning the data and hope to begin analysing them soon. 2. "Is air pollution associated with neuroimaging changes" - Karolinska Institutet, Sweden. Contributions: This work is at a preliminary stage but we are cleaning the data and hope to begin analysing them soon.
Collaborator Contribution Sharing Joint research expertise.
Impact No outcomes to date as the collaboration is very new.
Start Year 2016
 
Description Alan Gow - Guest Professor Programme 
Organisation University of Copenhagen
Department Center for Healthy Aging
Country Denmark 
Sector Academic/University 
PI Contribution Guest professor programme collaboration between the Center for Healthy Aging (University of Copenhagen), the Centre for Cognitive Ageing and Cognitive Epidemiology (University of Edinburgh) and Heriot-Watt University. Five research visits (2011 to 2015). The collaboration continues with further planned research visits 2016 onwards.
Collaborator Contribution They were research collaborators.
Impact resulted in five papers to date (3 published, 1 under review, 1 in preparation). Gow, A. J., Mortensen, E. L., & Avlund, K. (2012). Activity participation and cognitive aging from age 50 to 80 in the Glostrup 1914 Cohort. Journal of the American Geriatrics Society, 60, 1831-1838. Gow, A. J., Avlund, K., & Mortensen, E. L. (2014). Occupational characteristics and cognitive aging in the Glostrup 1914 Cohort. The Journals of Gerontology, Series B: Psychological Sciences, 69, 228-236. Gow, A. J., Avlund, K., & Mortensen, E. L. (2014). Leisure activity associated with cognitive ability level, but not cognitive change. Frontiers in Psychology. doi: 10.3389/fpsyg.2014.01176 Gow, A. J., Mortensen, E. L. & Avlund. K. (under review). Social resources and cognitive aging across thirty years: the Glostrup 1914 Cohort.
Start Year 2011
 
Description Allerhand - BMI and cognitive ageing (2013) 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution The Centre's statistician is engaged in a collaborative research project on BMI and cognition.
Collaborator Contribution This is a collaborative research project. Previously, a researcher from Karolinska has visited the Centre.
Impact Publications are forthcoming.
Start Year 2013
 
Description Allerhand - BMI and cognitive ageing (2013) 
Organisation University of California, Riverside
Country United States 
Sector Academic/University 
PI Contribution The Centre's statistician is engaged in a collaborative research project on BMI and cognition.
Collaborator Contribution This is a collaborative research project. Previously, a researcher from Karolinska has visited the Centre.
Impact Publications are forthcoming.
Start Year 2013
 
Description Alzheimer Scotland 
Organisation Alzheimer Scotland
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Clinical Research Training Fellowship collaboration with the Scottish Dementia Clinical Research Network (David Batty is Co-Supervisor), analyses based on the Lothian Birth Cohorts
Collaborator Contribution Clinical Research Training Fellowship
Impact The Fellow has been appointed (Dr Tom Russ) and his research is progressing well
Start Year 2009
 
Description Alzheimer's Disease and dementia collaborations - Sergio Della Sala 
Organisation San Paolo Hospital
Country Brazil 
Sector Hospitals 
PI Contribution Multiple projects on AD and dementia are being completed with these collaborators. Tpoics include: Memory binding in familial AD; dual-task in patients with AD, MCI and chronic depression; closing-in phenomenon in AD and other dementias; dual-task in dementias; closing-in in dementia
Collaborator Contribution ExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertise
Impact Joint papers and joint grants are being generated.
 
Description Alzheimer's Disease and dementia collaborations - Sergio Della Sala 
Organisation Tbilisi State Medical University
Country Georgia 
Sector Academic/University 
PI Contribution Multiple projects on AD and dementia are being completed with these collaborators. Tpoics include: Memory binding in familial AD; dual-task in patients with AD, MCI and chronic depression; closing-in phenomenon in AD and other dementias; dual-task in dementias; closing-in in dementia
Collaborator Contribution ExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertise
Impact Joint papers and joint grants are being generated.
 
Description Alzheimer's Disease and dementia collaborations - Sergio Della Sala 
Organisation University of Ancona
Country Italy 
Sector Academic/University 
PI Contribution Multiple projects on AD and dementia are being completed with these collaborators. Tpoics include: Memory binding in familial AD; dual-task in patients with AD, MCI and chronic depression; closing-in phenomenon in AD and other dementias; dual-task in dementias; closing-in in dementia
Collaborator Contribution ExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertise
Impact Joint papers and joint grants are being generated.
 
Description Alzheimer's Disease and dementia collaborations - Sergio Della Sala 
Organisation University of Antioquia
Country Colombia 
Sector Academic/University 
PI Contribution Multiple projects on AD and dementia are being completed with these collaborators. Tpoics include: Memory binding in familial AD; dual-task in patients with AD, MCI and chronic depression; closing-in phenomenon in AD and other dementias; dual-task in dementias; closing-in in dementia
Collaborator Contribution ExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertise
Impact Joint papers and joint grants are being generated.
 
Description Alzheimer's Disease and dementia collaborations - Sergio Della Sala 
Organisation University of California, Santa Barbara
Country United States 
Sector Academic/University 
PI Contribution Multiple projects on AD and dementia are being completed with these collaborators. Tpoics include: Memory binding in familial AD; dual-task in patients with AD, MCI and chronic depression; closing-in phenomenon in AD and other dementias; dual-task in dementias; closing-in in dementia
Collaborator Contribution ExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertise
Impact Joint papers and joint grants are being generated.
 
Description Alzheimer's Disease and dementia collaborations - Sergio Della Sala 
Organisation University of Osnabrück
Country Germany 
Sector Academic/University 
PI Contribution Multiple projects on AD and dementia are being completed with these collaborators. Tpoics include: Memory binding in familial AD; dual-task in patients with AD, MCI and chronic depression; closing-in phenomenon in AD and other dementias; dual-task in dementias; closing-in in dementia
Collaborator Contribution ExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertise
Impact Joint papers and joint grants are being generated.
 
Description Alzheimer's Disease and dementia collaborations - Sergio Della Sala 
Organisation University of Trento
Country Italy 
Sector Academic/University 
PI Contribution Multiple projects on AD and dementia are being completed with these collaborators. Tpoics include: Memory binding in familial AD; dual-task in patients with AD, MCI and chronic depression; closing-in phenomenon in AD and other dementias; dual-task in dementias; closing-in in dementia
Collaborator Contribution ExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertiseExpertise
Impact Joint papers and joint grants are being generated.
 
Description Andrew McIntosh 
Organisation University of Edinburgh
Department Division of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided brain imaging data and personality and mood variables.
Collaborator Contribution This has allowed the examination of brain imaging associations with additional phenotypes, in this case personality and mood states of anxiety and depression.
Impact A paper has been submitted to a journal.
Start Year 2010
 
Description Assessment of category fluency in ageing - MacPherson 
Organisation Korea Advanced Institute of Science and Technology (KAIST)
Department Computer Science Department
Country Korea, Republic of 
Sector Academic/University 
PI Contribution As a result of Challenge Investment funding, University of Edinburgh, my colleague Dr Maria Wolters and I made our first visit to our new collaborator, Professor Jong C. Park, School of Computing, KAIST, South Korea in February 2015. We have started examining traditional and acoustic data from semantic fluency, as well as, manual and semi-automated scoring methods for the task in both healthy and pathological aging. The School of Computing have devised the automated scoring methods and my contribution is the design and interpretation of our fluency work.
Collaborator Contribution As a result of Challenge Investment funding, University of Edinburgh, my colleague Dr Maria Wolters and I made our first visit to our new collaborator, Professor Jong C. Park, School of Computing, KAIST, South Korea in February 2015. We have started examining traditional and acoustic data from semantic fluency, as well as, manual and semi-automated scoring methods for the task in both healthy and pathological aging. The School of Computing have devised the automated scoring methods and my contribution is the design and interpretation of our fluency work.
Impact Papers published and others in preparation.
Start Year 2015
 
Description BSPID - Beverly Roberts 
Organisation British Society for the Psychology of Individual Differences (BSPID)
Country United Kingdom 
Sector Learned Society 
PI Contribution The CCACE scientific administrator is the conference organiser for the society. CCACE hosted the inaugural conference for the society in 2010 and organised conferences in 2011, 2012, 2013 and 2014.
Collaborator Contribution See above.
Impact Conference hosted and keynote talk given. Gaining a wider recognition of the work of CCACE among individual differences researchers in the UK.
Start Year 2009
 
Description Biomarkers for dementia and cognitive ageing - Russ 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution I will analyse the data.
Collaborator Contribution Glasgow will analyse urinary proteomic samples .
Impact None as yet.
Start Year 2015
 
Description British Society for the Psychology of Individual Differences (BSPID) 
Organisation British Society for the Psychology of Individual Differences (BSPID)
Country United Kingdom 
Sector Learned Society 
PI Contribution The British Society for the Psychology of Individual Differences (BSPID) is a new academic society formed in November 2009. As members of the CCACE are one of the major contributors to the individual differences research area in the UK the CCACE was invited to be a member of the founding committee and Beverly Roberts (Scientific Administrator) has taken the role of Society Conference Organiser. The CCACE will organise, run and host the first scientific meeting of the BSPID which will be held in Edinburgh in Spring 2010. A number of Centre members are all founding members of the BSPID.
Impact Beverly Roberts organised the first scientific conference in spring 2010. CCACE Director, Ian Deary, has been invited to give the keynote address at this meeting. Beverly Roberts and the CCACE commissioned a professional graphic designer to design the BSPID logo.
Start Year 2009
 
Description CCACE - Oregon Health and Sciences University (OHSU) 
Organisation Oregon Health and Science University
Department Layton Aging & Alzheimer's Disease Center
Country United States 
Sector Academic/University 
PI Contribution CCACE hosted a visit from the Oregon Health and Sciences University team of senior scientists (8 people) in September 2013. The aim was to develop more formal collaborations between the UK and USA in ageing research. The team spent 2 days with CCACE in various meet the staff meetings.
Collaborator Contribution The OHSU team have offered to host 3 members of CCACE on a return visit to Oregon in February 2014. Further correspondence has taken place between Dr Alex WEiss and Professor Jean Manson and the team at Oregon and planned collaborations are ongoing.
Impact There are plans to create formal collaborations between CCACE and OHSU scienitsts that will result after the reciprocal visit. This is intended to lead to joint publications between CCACE and OHSU.
Start Year 2013
 
Description CRFR - Beverly Roberts/Robin Morton 
Organisation University of Edinburgh
Department Centre for Research in Families and Relationships (CRFR)
Country United Kingdom 
Sector Academic/University 
PI Contribution After initial discussions between the Directors of both CCACE and CRFR, the CCACE scientific administrator and KE officer set up joint meetings to discuss possible overlaps of research interest.
Collaborator Contribution The group have provided expertise to widen the Centre's area of research.
Impact Both groups are in discussions and plan to put together a joint grant proposal for submission in 2011. An outlinr application was successful.
Start Year 2010
 
Description Carroll, Moss - University of Birmingham 
Organisation University of Birmingham
Department College of Life and Environmental Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Personality and cognition expertise, analysis and co-authorship
Collaborator Contribution Epidemiological expertise, analysis and co-authorship
Impact Publications: 19321850 19344891 20624519 20875850 20045139 20624519 20875850 20875850 21166685 21709165 21871931 23938060 23434472
Start Year 2008
 
Description Celtic Ageing Network - Bevely Roberts 
Organisation Swansea University
Country United Kingdom 
Sector Academic/University 
PI Contribution The Celtic Ageing Network was set up by staff at the University of Swansea to bring together academics, policy makers, practitioners and researchers in ageing from the UK devolved nations. The CCACE scientific administrator made initial contact with the group at the CogWorks conference in Belfast.
Impact The Centre is now a formal member of the network and a grant application is currently being planned to examine social attitudes to ageing with CCACE as a co-applicant.
Start Year 2010
 
Description Center for Neurogenomics and Cognitive Research (CNCR) 
Organisation Free University of Amsterdam
Department Center for Neurogenomics and Cognitive Research
Country Netherlands 
Sector Academic/University 
PI Contribution The CNCR is a world-class group of researchers working on genetic contributions to cognitive abilities. They share some of the aims of the CCACE. Lothian Birth Cohort 1936 DNA samples are included in a study investigating genetic influences on cognitive ability.
Collaborator Contribution It has provided data for the team to perform meta-anlaysis.
Impact Analyses are in progress and publications are in preparation. Some joint publications have already appeared: 18855131 18493267
Start Year 2009
 
Description Centre for Neuroimaging Sciences, Kings College London - Maria Parra 
Organisation King's College London
Department Institute of Psychiatry, Psychology & Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution Centre member Dr Mario Parra is collaborating with Kings College London on this study entitled: "Mapping the relationship between white matter and cognitive function across the adult lifespan". This project funded by the Biomedical Research Council aims to map the relationship between white matter and cognitive function across the adult lifespan. Dr Parra's team will be starting neuropsychological testing before 2011 end, and data collection is expected to take about 12 months.
Collaborator Contribution Expertise and neuropsychological testing.
Impact Dr Parra has trained the researchers and data collection will start before end 2011.
Start Year 2011
 
Description Cognitive Ageing Genetics in England and Scotland (CAGES) consortium 
Organisation Cognitive Ageing Genetics in England and Scotland consortium
Country United Kingdom 
Sector Academic/University 
PI Contribution The CAGES consortium aims to perform GWAS meta-analysis of cognition in old age using data from the LBC1921 and LBC1936 studeies with other international collaborators.
Collaborator Contribution The group has provided data for meta-analysis.
Impact Data from the LBC1921 and LBC1936 studies have been transferred for meta-analysis. Papers on cognition and old age have begun to appear: 21826061. In addition, a paper has been accepted for Nature. Further analyses are being conducted and papers are being prepared.
Start Year 2010
 
Description Cognitive estimation in an Italian population - MacPherson 
Organisation Fondazione IRCCS Istituto Nazionale dei Tumori
Country Italy 
Sector Charity/Non Profit 
PI Contribution My collaborators translated into Italian the new versions of the Cognitive Estimation task (CET) devised by me (MacPherson et al., 2014, PLOS-One) and administered the tasks to the healthy population to examine the influence of age, gender and education on performance and providing Italian normative data. We are now examining whether non-demented Parkinson's disease patients are impaired on the CET and what underlies their impairments. My collaborators have assessed the participants, ran the statistical analyses and wrote drafts of the manuscripts. I have devised the tests, provided the theoretical input into the work and have also contributed to the writing of the manuscripts.
Collaborator Contribution My collaborators translated into Italian the new versions of the Cognitive Estimation task (CET) devised by me (MacPherson et al., 2014, PLOS-One) and administered the tasks to the healthy population to examine the influence of age, gender and education on performance and providing Italian normative data. We are now examining whether non-demented Parkinson's disease patients are impaired on the CET and what underlies their impairments. My collaborators have assessed the participants, ran the statistical analyses and wrote drafts of the manuscripts. I have devised the tests, provided the theoretical input into the work and have also contributed to the writing of the manuscripts.
Impact It has resulted in new versions of a test that is typically used in neuropsychological clinics in Italy.
Start Year 2015
 
Description Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) cognitive consortium 
Organisation International Heart and Aging Research Genetics Consortium
Country United States 
Sector Public 
PI Contribution The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-anlayses and replication opportunities among multiple large and well-phenotyped longitudinal cohort studies. Cognitive measurements from the Lothian Birth Cohorts have been added to the NeuroCHARGE group and meta-analysis is in progress.
Collaborator Contribution It has provided data for the team to perform meta-anlaysis.
Impact A material transfer agreement is in place with the CHARGE consortium. We have already provided data from the LBC1921 and LBC1936 cohorts. Anlayses have already been initiated. Various brain and blood-related traits are now being investigated including brain imaging, prothrombin time, activated partial thromboplastin time, d-dimer, serum uric acid, serum albumin, fibrinogen. A 2-weekly conference call takes place. A first series of publications is being planned on the basis of the traits noted above. The following publications have appeared: 21909110 21946350 21502573. Other analyses are completed and publications planned. Deary and Davies in CCACE are leading the CHARGE analysis of general cognitive ability and analyses are in progress and a publication is being prepared.
Start Year 2009
 
Description Cold Spring Harbour Laboratory 
Organisation Cold Spring Harbor Laboratory (CSHL)
Country United States 
Sector Charity/Non Profit 
PI Contribution Lothian Birth Cohort 1936 DNA samples are included in a Cold Spring Harbour Laboratories DISC1 deep sequencing project to identify rare variants associated with mental illness and cognitive ability.
Collaborator Contribution It has provided data for the team to perform meta-anlaysis.
Impact A material transfer agreement formalises the collaboration. A small grant was awarded from CSHL to Ian Deary for sample management. DNA from LBC 1936 have been transferrred and has now been sequenced. Analyses of the DNA sequencing data are in progress. In 2011, this project has been extended to known DISC1 interactors.
Start Year 2009
 
Description Cox - Interconnectivity of Cerebral Sites - Colab. Pilot 
Organisation Lagos State University
Department Department of Computer Science
Country Nigeria 
Sector Academic/University 
PI Contribution Provided the concept and neuranatomical basis for development of a study specific method for identifying and measuring white matter connectivity between cerebral regions in older participants.
Collaborator Contribution The proposed study represents an international collaborative effort that marries expertise in neuropsychology, neuroanatomy, computer science and ageing research.
Impact A method for exploiting manual frontal lobe parcellations to measure specific site-to-site white matter connectivity in the brains of older persons. In addition to the method development, several manuscripts are planned which will examine the cognitive correlates of individual differences in intra-frontal and fronto-hippocampal connections. Preliminary results presented at two conferences (OHBM 2014 by Aribisala, and ISMRMB 2014 by Cox). Manuscript in preparation, collaboration with Psychiatry at UoE (Prof Lawrie) using this method in preliminary stages. Additional development work planned for use in the Lothian Birth cohorts.
Start Year 2013
 
Description Danish Twin Study 
Organisation University of Copenhagen
Department Center for Healthy Aging
Country Denmark 
Sector Academic/University 
PI Contribution Statistical analyis and writing of papers.
Collaborator Contribution Extensive data on twin samples.
Impact Publications: 19208755 19861402 Johnson et al. (2009) Behaviour Genetics 39;659
Start Year 2008
 
Description David Bartholomew 
Organisation London School of Economics and Political Science (University of London)
Department Department of Social Policy
Country United Kingdom 
Sector Academic/University 
PI Contribution Professor David Bartholomew is a retired professor from the London School of Economics. Ian Deary collaborates with Professor Bartholomew on the biologiy and modelling of cognitive functions. The CCACE statistician, Dr Mike Allerhand, has been added to this collaboration. Dr Allerhand is completing the statistical analysis for a collaborative project on random number generators and a simulation of Thomson's "bonds" (group factor) model.
Collaborator Contribution See above.
Impact Two published papers have appeared from this collaboration, and one more is submitted. One of the publications is a major theoretical contribution to the biological and statistical conception of ability differences and ageing 19618987 19321036. This collaborations' outputs have also been presented at conferences, including the History of Education group conference in Scotland and the British Psychological Society's history and philosophy group's annual conference. A further publication appeared in 2013: http://dx.doi.org/10.1016/j.intell.2013.03.007
Start Year 2009
 
Description Delbox as an activation task - Tieges 
Organisation Johns Hopkins University
Country United States 
Sector Academic/University 
PI Contribution Collaborative projects (until 2018) between the University of Edinburgh and Johns Hopkins University, US: Use of Delbox as an activation task-associated with attention in measurement of brain function using functional near-infrared spectroscopy (fNIRS). The Delbox will be used in several studies which are supported by Hitachi with funding and equipment.
Collaborator Contribution Their academic expertise.
Impact The first scientific paper is submitted.
Start Year 2016
 
Description Dementia and Delirium Implementation Group - Susie Shenkin 
Organisation NHS Lothian
Country United Kingdom 
Sector Public 
PI Contribution CCACE member Dr Susie Shenkin has been a member of the Dementia and Delirium Implementation Group (NHS Lothian, UK) since 2009. The group works towards improving the care of patients with dementia and delirium in NHS Lothian using audit, education and patient experience.
Impact Documentation of diagnosis of dementia and delirium has improved. In association with this group Dr Shenkin is also on the Lothian Dementia Strategy Implementation and Monitoring Group (NHS Lothian), which aims to develop and implement strategy to improve care of patients with dementia in community and hospital.
Start Year 2009
 
Description Developing a non-invasive cognitive aid to diagnosis and follow up of Alzheimer's Disease - Robert Logie 
Organisation Toshiba
Country Japan 
Sector Private 
PI Contribution Over 20 years of laboratory based scientific research, development of prototype software and initial clinical trials.
Collaborator Contribution Assisted in the development of a diagnostic tool.
Impact Collaboration commenced in October 2010. Planned output will be a proven prototype diagnostic aid that may be used in Primary Care and also for evaluation of the effectiveness of interventions in clinical trials. Interest expressed for inclusion in clinical trials of pharmaceutical interventions due to run in 2011.
Start Year 2010
 
Description Dr Barbara van Munster University of Amsterdam - Alasdair MacLullich 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Collaboration on a cerebrospinal fluid collection in patients with delirium project.
Collaborator Contribution Expertise.
Impact This has resulted in two oral presentations at the European Delirium Association annual meeting in Nov 2010, and two forthcoming manuscript submissions.
Start Year 2010
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Lille University Hospital
Country France 
Sector Hospitals 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Medical University of Graz
Country Austria 
Sector Academic/University 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Paris Diderot University
Country France 
Sector Academic/University 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description EU Joint programme - Neurodegenerative Disease Research 
Organisation Technical University of Munich
Country Germany 
Sector Academic/University 
PI Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Collaborator Contribution This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Impact This was a successful joint bid for funding under the EU Joint Programme's call "Working groups to inform cohort studies in Neurodegenerative disease research".
Start Year 2013
 
Description Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) consortium 
Organisation National Center for Biotechnology Information (NCBI)
Country United States 
Sector Public 
PI Contribution The ENIGMA consortium aims to perform meta-analysis of brain imaging and genetics in ageing using data from the LBC1921 and LBC1936 studies with other international collaborators.
Collaborator Contribution Data from international collaborators has been brought together to perfom meta-analysis.
Impact Data from the LBC1921 and LBC1936 has been transferred for meta-analysis. Papers on brain imaging, genetics and ageing are currently being prepared. One paper is in revision with Nature Genetics titled "Common genetic polymorphisms contribute to the variation in human hippocampal and intracranial volume". Potentially this collaboration with ENIGMA will extend to include analysis of subcortical brain structures. Also, Deary has made a proposal to take a lead on the GWAS analysis of brain white matter integrity.
Start Year 2010
 
Description Euan Macdonald Centre for Motor Neurone Disease Research 
Organisation University of Edinburgh
Department Euan Macdonald Centre for Motor Neurone Disease Research
Country United Kingdom 
Sector Public 
PI Contribution Centre member Dr Sharon Abrahams, together with Professor Ian Deary begin_of_the_skype_highlighting     end_of_the_skype_highlighting and Professor Siddharthan Chandran, set up the first joint Euan Macdonald Centre for Motor Neurone Disease Research and CCACE Capacity Building PhD Studentship. This PhD initiative is with the recently opened Motor Neurone Disease Centre in Edinburgh of which Dr Abrahams is a founding member.
Collaborator Contribution Formation of a joint Centre capacity building PhD studentship.
Impact A PhD studentship on executive dysfunction, speed of information processing and white matter changes in Motor Neurone Disease. The studentship began in 2009 and the PhD will be completed by 2012. Analyses are in progress and publications are in preparation.
Start Year 2009
 
Description GERAD consortium 
Organisation Medical Research Council (MRC)
Department MRC Centre for Neuropsychiatric Genetics and Genomics
Country United Kingdom 
Sector Public 
PI Contribution GERAD is a large case-control study of Alzheimer's disease run from the MRC Centre for Psychiatric Genetics at Cardiff Univeristy in Wales. The Lothian Birth Cohorts 1921 and 1936, studies led by Professor Ian Deary, will be used as controls in this study.
Collaborator Contribution Collaborators have brought data and expertise.
Impact A material transfer agreement has been completed between the two institutions. Data from the GWAS studies of Ian Deary's cohorts in Edinburgh have been prepared and are being transferred to Cardiff for collaborative analyses. The following publication appeared in the Journal of Alzheimer's Disease in 2011: 22027014. Further analyses are being conducted and papers being prepared. 22693153
Start Year 2009
 
Description GERAD consortium - GWAS of Alzheimer's disease 
Organisation Genetic and Environmental Risk in Alzheimer's Disease (GERAD)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution GERAD provided us with summary data from a large genome-wide association study of Alzheimer's Disease. From this we created polygenic risk scores for Alzheimer's disease in members of LBC1936, LBC1921, ABC1936 and the Manchester and Newcastle Longitudinal Studies of Cognitive Ageing.
Collaborator Contribution See above.
Impact The following publication has arisen: Harris SE, Davies G, Luciano M, Payton A, Fox HC, Haggarty P, Ollier W, Horan M, Porteous DJ, the Genetic and Environmental Risk for Alzheimer's Disease (GERAD1) Consortium, Starr JM, Whalley LJ, Pendleton N, Deary IJ (2014) Polygenic risk for Alzheimer's Disease is not associated with cognitive ability or cognitive aging in non-demented older people. Journal of Alzheimer's Disease. 39(3):565-74. doi: 10.3233/JAD-131058.
Start Year 2012
 
Description Generation Scotland 
Organisation Generation Scotland
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution David Porteous is one of the Principal Investigators in Generation Scotland. Ian Deary oversees the cognitive and personality and mood phentotypes in Generation Scotland. CCACE Knowledge Exchange Officer, Robin Morton retains the knowledge exchange role within Generation Scotland. The CCACE database manager, Mr Dave Liewald, developed this collaboration in reponse to the Generation Scotland study team asking the CCACE for assistance in developing a data acquisition laboratory information system.
Impact Porteous and Deary are making further grant applications to work with Generation Scotland data and to gather new data. Publications are appearing and are in preparation. Dave Liewald developed software for the group. The CCACE's Database Manager (Liewald) and the CCACE's Statistical Geneticist (MacLeod) have led on a publication from this collaboration (19181915). In 2011 CCACE members working on Generation Scotland have begun a collaboraton with Aarhus University in Denmark of candidate gene analysis for depression and cognition, which has resulted in a publication.
Start Year 2009
 
Description Genome Wide Association Study (GWAS) of personality 
Organisation National Institute on Aging
Country United States 
Sector Public 
PI Contribution Nine research groups (of which Edinburgh is one) are contributing to a GWAS consortium study of personality. It is headed by Paul Costa Jr.
Collaborator Contribution Collaborators have brought data and expertise.
Impact Our data have already been sent to the consortium and a paper with total N = 16000 subjects has been published in Molecular Psychiatry: 21173776. Further analysis and publications are being prepared.
Start Year 2008
 
Description Geographical variation and environmental risk factors for dementia - Russ 
Organisation Health Statistics Unit
Country Italy 
Sector Public 
PI Contribution Analyse data available on dementia risk factors in an Italian population study.
Collaborator Contribution Provide data.
Impact Brief report due to be submitted for publication with other papers planned.
Start Year 2015
 
Description Geographical variation and environmental risk factors for dementia in Chile - Russ 
Organisation University of Talca
Country Chile 
Sector Academic/University 
PI Contribution This work is at a preliminary stage but my Chilean colleagues have provide data and I have analysed them
Collaborator Contribution Provided data.
Impact Brief report about to be submitted for publication; others planned.
Start Year 2015
 
Description Geographical variation and environmental risk factors for dementia in Japan - Russ 
Organisation Hokkaido University
Country Japan 
Sector Academic/University 
PI Contribution This work is at a preliminary stage but my Japanese colleagues have agreed to collaborate and provide data; I will analyse these.
Collaborator Contribution This work is at a preliminary stage but my Japanese colleagues have agreed to collaborate and provide data; I will analyse these.
Impact None as yet.
Start Year 2015
 
Description Geographical variation and environmental risk factors for dementia in New Zealand - Russ 
Organisation Auckland University of Technology (AUT)
Country New Zealand 
Sector Academic/University 
PI Contribution This is at a preliminary stage. We are discussing availability of data and an exchange visit by Dr Katherine Walesby is planned for this year.
Collaborator Contribution Provide data.
Impact None as yet.
Start Year 2015
 
Description Geographical variation in dementia - Russ 
Organisation Rush University
Country United States 
Sector Academic/University 
PI Contribution Applied to use their Religious Orders Study data and this has recently been approved.
Collaborator Contribution Provided data.
Impact Publications are being prepared.
Start Year 2015
 
Description Glasgow Science Centre 
Organisation Glasgow Science Centre
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The Centre's knowledge exchange officer, Dr Robin Morton, has made contact with Robin Hoyle who is Science Director at the Glasgow based Science Centre.
Impact Robin Morton has attended one meeting with the Glasgow Science Centre with the result that they are now keen to involve the Centre in future displays. The Science Centre are interested in taking some matrial from the CCACE to show examples of "live" research in their new "labs" for the public. The work of some CCACE members will be used for this.
Start Year 2009
 
Description Glasgow University global methylation 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Analysed data.
Collaborator Contribution They measured global methylation levels in Lothian Birth Cohort 1936 samples.
Impact Global methylation content and cognitive and physical ability in old age: the Lothian Birth Cohort 1936. Sarah Harris (CCACE Bioinformatician) analysed the data and presented it at the The Epigenomics of Complex Diseases meeting at Johns Hopkins University 12th -15th October 2012.
Start Year 2011
 
Description Gow - A Tablet for Healthy Ageing 
Organisation University of Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution Gow contributed to the development of a new research programme, A Tablet for Healthy Ageing, including obtaining funding from The Dunhill Medical Trust.
Collaborator Contribution Contributed to the development of a new research programme, A Tablet for Healthy Ageing, including obtaining funding from The Dunhill Medical Trust.
Impact This is a new research programme to develop a supported intervention programme utilising tablet PCs and other technologies to improve the health and well-being of older adults. The programme received funding from The Dunhill Medical Trust and is employing a post-doctorate research fellow based at Heriot Watt University.
Start Year 2014
 
Description Gow - School of Built Environment, Heriot Watt University 
Organisation Heriot-Watt University
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributing expertise in cognitive ageing to a paper looking at housing built year and residence duration using the US NHANES study.
Collaborator Contribution Contributing expertise in the built environment to a paper looking at housing age and residence duration and cognitive function.
Impact This collaboration resulted in a paper which is currently under review, and a further application to access UK Biobank data. Shiue, I. & Gow, A. J. (under review). Housing built year and residence duration are associated with cognitive function in the elderly: US NHANES, 1999-2002.
Start Year 2014
 
Description HAGIS or THSLS - Scottish Longitudinal (cohort) study 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Deary and Fawns-Ritchie from CCACE are providing expertise in cognitive testing to form the cognitive battery for the new planned Scottish longitudinal cohort. There is pilot funding in place (awarded to Stirling) from NIH.
Collaborator Contribution Partners are providing the organisation of the planned cohort and the expertise in economic and other social aspects of the data which will be gathered from the new cohort.
Impact Pilot grant awarded from NIH.
Start Year 2013
 
Description HAGIS or THSLS - Scottish Longitudinal (cohort) study 
Organisation University of Stirling
Country United Kingdom 
Sector Academic/University 
PI Contribution Deary and Fawns-Ritchie from CCACE are providing expertise in cognitive testing to form the cognitive battery for the new planned Scottish longitudinal cohort. There is pilot funding in place (awarded to Stirling) from NIH.
Collaborator Contribution Partners are providing the organisation of the planned cohort and the expertise in economic and other social aspects of the data which will be gathered from the new cohort.
Impact Pilot grant awarded from NIH.
Start Year 2013
 
Description HALCyon 
Organisation HALCyon
Country United Kingdom 
Sector Academic/University 
PI Contribution The HALCyon collaborative research programme is funded by the UK Research Councils. From the Centre, Ian Deary, John Starr and Catherine Gale are PI's. The Centre receives funding from HALCyon. It is a consortium of ageing cohorts across the UK which has the aim of helping improve the lives of older people through better understanding of how healthy ageing is affected by social, psychological and biological factors acting across the whole of a person?EUR(TM)s life. It brings together an interdisciplinary group of scientists working on nine UK cohort studies to understand three main aspects of healthy ageing. The Edinburgh based Lothian Birth Cohort 1936 study forms one of the nine cohorts who contribute data.
Collaborator Contribution Data from the LBC 1936 and 1921 studies have contributed to the overall meta-analysis.
Impact Publications are emerging. The following papers have been published: 19864640 20214846 20843964 21225350 21297868 21332924 21349224 21542061 22114723 25073452 24563560 24365661 23922731 23894584. Further analyses are underway and publications are being prepared.
Start Year 2008
 
Description Human episodic memory - Davies/Deary 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Title: Integrated systems approach identifies genetic nodes and network for human episodic memory This collaboration is based in the UK. Genome-wide association analyses of memory phenotypes were performed on the Lothian Birth Cohorts in an attempt to replicate findings from a co-expression network analysis performed on human hippocampus samples.
Collaborator Contribution See above
Impact We were able to successfully replicate these findings and a manuscript has been submitted. This collaboration is multi-disciplinary, it involves genetics, psychology (cognition), genomic medicine, Clinical neurogenetics, and neurology.
Start Year 2014
 
Description Human episodic memory - Davies/Deary 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Title: Integrated systems approach identifies genetic nodes and network for human episodic memory This collaboration is based in the UK. Genome-wide association analyses of memory phenotypes were performed on the Lothian Birth Cohorts in an attempt to replicate findings from a co-expression network analysis performed on human hippocampus samples.
Collaborator Contribution See above
Impact We were able to successfully replicate these findings and a manuscript has been submitted. This collaboration is multi-disciplinary, it involves genetics, psychology (cognition), genomic medicine, Clinical neurogenetics, and neurology.
Start Year 2014
 
Description INNOGEN Centre 
Organisation Economic and Social Research Council
Country United Kingdom 
Sector Public 
PI Contribution The CCACE has a large genetics team and through the Centre's knowledge exchange officer, Dr Robin Morton, the CCACE and INNOGEN have now formed formal links to work together on genetics and genomics. Robin Morton is in conversation with Ms Lara Crossland who is INNOGEN's communication and networking officer.
Impact Robin Morton has atteded one meeting with the group which has raised the profile of the CCACE.
Start Year 2009
 
Description Institute for Behavioural Genetics 
Organisation University of Colorado
Department Institute for Behavioural Genetics
Country United States 
Sector Academic/University 
PI Contribution The CCACE genetics team are involved in a collaboration with Professor Matthew Keller at the Institute for Behavioural Genetics, CU Boulder. This collaboration aims to investigate the effects of genomic measures of distal inbreeding (% genome in runs of homozygosity) on IQ.
Collaborator Contribution The Centre genetics team have benefitted from the genetics skills of Matthew Keller.
Impact A data transfer agreement has been made between the two Centres. Dr Keller is analysing the data provided by the LBC cohorts. Anlyses are in progress. Publications will proceed when analyses are completed.
Start Year 2009
 
Description Institute of Cognitive Neurology, Buenos Aires - Mario Parra 
Organisation The Institute of Cognitive and Behavioural Neurology
Country Argentina 
Sector Academic/University 
PI Contribution Dr Parra, CCACE member, is working on this multi-centre collaborative project entitled: "Default brain network and connectivity problems in mild cognitive impairment and AD: Developments of protocol for electrophysiological (EEG and ERPs) recordings in resting state and during cognitive processing." His research team will recruit patients with mild cognitive impairment (MCI) through the Scottish Dementia Network.
Collaborator Contribution The group in Argentina has a long experience in default brain network (DMN) and its use and interpretation in mild cognitive impairment (MCI), and they will provide the methodology and training. They will also collect data in MCI patients. The group in Colombia will adopt this working protocol and will provide high density EEG data from carriers of the mutation E280A in the preclinical stages.
Impact Recruitment for the study is underway
Start Year 2011
 
Description Institute of Cognitive Neurology, Buenos Aires - Mario Parra 
Organisation The Institute of Cognitive and Behavioural Neurology
Country Argentina 
Sector Academic/University 
PI Contribution Dr Parra, CCACE member, is working on this multi-centre collaborative project entitled: "Default brain network and connectivity problems in mild cognitive impairment and AD: Developments of protocol for electrophysiological (EEG and ERPs) recordings in resting state and during cognitive processing." His research team will recruit patients with mild cognitive impairment (MCI) through the Scottish Dementia Network.
Collaborator Contribution The group in Argentina has a long experience in default brain network (DMN) and its use and interpretation in mild cognitive impairment (MCI), and they will provide the methodology and training. They will also collect data in MCI patients. The group in Colombia will adopt this working protocol and will provide high density EEG data from carriers of the mutation E280A in the preclinical stages.
Impact Recruitment for the study is underway
Start Year 2011
 
Description International Consortia of Blood Pressure (ICBP-GWAS) 
Organisation International Consortia of Blood Pressure (ICBP-GWAS)
Country United States 
Sector Public 
PI Contribution The ICBP-GWAS consortium aims to perform GWAS meta-analysis of blood pressure data using data from the LBC1921 and LBC1936 studies with other international collaborators.
Collaborator Contribution Data sharing between Edinburgh and international collaborators in ongoing.
Impact Data from the LBC1921 and LBC1936 studies have been transferred for meta-analysis work. The following paper has appeared: 21909110
Start Year 2010
 
Description International genetics collaboration investigating runs of homozygosity (ROHgen) 
Organisation University of Edinburgh
Department Centre for Population Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution This is an international collaboration investigating the effects of runs of homozygosity on a number of health-related traits including cognition. Manuscript in preparation.
Collaborator Contribution This is an international collaboration investigating the effects of runs of homozygosity on a number of health-related traits including cognition. Manuscript in preparation.
Impact A manuscript is currently in preparation.
Start Year 2014
 
Description Interstellar Initiative 
Organisation Columbia University
Country United States 
Sector Academic/University 
PI Contribution Selected for the Japan Agency for Medical Research and Development and the New York Academy of Sciences' Interstellar Initiative (March 2017-February 2018). I am one of 50 international early career researchers in neuroscience, regenerative medicine, and cancer selected for this scheme which consists of two intensive funding bid development meetings with mentoring hosted by the NYAS and $40,000 funding for each team of two or three to enhance their application to funding agencies.
Collaborator Contribution Academic expertise.
Impact None as yet.
Start Year 2017
 
Description Interstellar Initiative 
Organisation Osaka University
Country Japan 
Sector Academic/University 
PI Contribution Selected for the Japan Agency for Medical Research and Development and the New York Academy of Sciences' Interstellar Initiative (March 2017-February 2018). I am one of 50 international early career researchers in neuroscience, regenerative medicine, and cancer selected for this scheme which consists of two intensive funding bid development meetings with mentoring hosted by the NYAS and $40,000 funding for each team of two or three to enhance their application to funding agencies.
Collaborator Contribution Academic expertise.
Impact None as yet.
Start Year 2017
 
Description Jokela - Helsinki University 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution Analysis and paper writing.
Collaborator Contribution Epidemiological analysis
Impact Publications: 19706576 19808765 19648547 19155280 19592627 21130836 25262544 25061139 24504367 23957901
Start Year 2007
 
Description Karolinska Institutet, SATSA group 
Organisation Karolinska Institute
Department Department of Medical Epidemiology and Biostatistics
Country Sweden 
Sector Academic/University 
PI Contribution The Karolinska team have contributed three replication analyses to a major study of the genetics of cognitive ageing being led by the Edinburgh team. Here, the major Karolinska contact is Prof Nancy Pederson. Dr Mike Allerhand, the Centre's employed statisitician, has contributed statistical expertise to this collaboration, on a study of the relationship between body mass and decline in cognitive functioning.
Collaborator Contribution Provision of data and analyses from The Swedish Adoption/Twin Study of Aging (SATSA). , and other ageing cohorts. Also, postdoctoral worker Dr Dahl has visited Edinburgh for three weeks, and other visits are planned.
Impact A paper is at the advcance draft stage prior to publication. The results were presented at the International Conference of Alzheimers Disease, and at other conferences. A visit by Dr Anna Dahl took place to CCACE for three weeks and longer visits are planned for 2012 and 2013.
Start Year 2011
 
Description Lingo Flamingo social enterprise 
Organisation Social Enterprise UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Intellectual and research expertise to measure the cognitive effects of language learning on older adults.
Collaborator Contribution Provide language courses and tutors to adult learners.
Impact None to date as the collaboration has only recently formed.
Start Year 2016
 
Description Lowe, Stott - University of Glasgow 
Organisation University of Glasgow
Department Institute of Biomedical and Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Lothian Birth Cohort samples, analysis and paper writing
Collaborator Contribution Expertise in biology of blood clotting and inflammation, analysis of smaples for these factors
Impact Publications: 19661193 19821022 19959761 20097662 20197283 20197530 20303064 21258858 21502573 21604878 21676170 23969696 23408906
Start Year 2007
 
Description MAGIC - international glycaemic traits genetics consortium 
Organisation MAGIC
Country United Kingdom 
Sector Public 
PI Contribution The is an international glycaemic traits genetics consortium. Current work is focussed on analysis of exome chip data.
Collaborator Contribution The is an international glycaemic traits genetics consortium. Current work is focussed on analysis of exome chip data.
Impact This is a new consortium and analysis is still underway.
Start Year 2014
 
Description MRC Centre for Analysis in Translational Epidemiology 
Organisation University of Bristol
Department MRC Centre for Causal Analyses in Translational Epidemiology
Country United Kingdom 
Sector Public 
PI Contribution MRC CAiTE Director, Professor George Davey Smith from Bristol, invited Ian Deary begin_of_the_skype_highlighting     end_of_the_skype_highlighting and the CCACE to be a formal collaborator with his Centre.
Collaborator Contribution Formal collaborations have been made between the two Centres which has resulted in new research.
Impact Members from each Centre are collaborating on new research topics and have papers in preparation with some published (18994662 18704700). This collaboration has also resulted in the CHIC consortium: see separate entry. 25201988 23722424 23358156. Davey Smith and senior members of his team are providing the expertise for a CCACE special interest day in epigenetics in November 2014 and Davey Smith is giving the CCACE St Andrew's Day lecture in 2014.
Start Year 2009
 
Description MRC Human Genetics Unit 
Organisation Medical Research Council (MRC)
Department MRC Human Genetics Unit
Country United Kingdom 
Sector Public 
PI Contribution The MRC Human Genetics Unit, Edinburgh, formally collaborates with the CCACE with two of its group being members of the CCACE. Dr Sarah Harris is the CCACE Geneticist and Professor Alan Wright is a full scientific member.
Collaborator Contribution Research collaborations have been made between CCACE members and MRC HGU staff.
Impact The HGU/CCACE collaboration formalises a long standing collaboration between Ian Deary, John Starr, and HGU staff. Since the inception of CCACE, the HGU have continued the generous practice of providing Sarah Harris with a desk in HGU which means that CCACE benefits from the rich genetic environment of HGU. This collaboration has produced a number of scientific papers. These include: 19397951 18855131 19776035 18317464 19077115 1820041 19418213 18493267 18946731 19290744 19077176 19821022 18977241 18628685 21194798 21840749
Start Year 2008
 
Description MRC Lifecourse Epidemiology Unit 
Organisation University of Southampton
Department MRC Lifecourse Epidemiology Unit
Country United Kingdom 
Sector Public 
PI Contribution MRC Epidemiology Resource Centre, Southampton, formally collaborates with the CCACE with one of its staff being a member of the CCACE. Dr Catherine Gale is a full scientific member of the CCACE. The Epidemiology Resource Centre is also part of the HALCyon collaboration, though the large majority of the CCACE-ERC joint publications arise from direct collaboration rather than through HALCyon.
Collaborator Contribution CCACE members and staff from the MRC LEU have collaborated on publications.
Impact This collaboration has produced a number of scientific papers. These include: 18235070 18204831 18525394 18801778 18477751 18594058 18718672 19147741 19189278 19344891 18947352 19907664 18480188 18380686 19047528 19047528 19907333 18812363 19864640 19907333 19483120 19706576 19321850 19251871 19955099 19047528 19864640 19907333 1838068619483120 19892320 19834050 20214846 Gale et al (2009). Intelligence 37;592-599; 21542061 21332924 21349224
Start Year 2008
 
Description MRC Population Health Sciences Research Network 
Organisation Medical Research Council (MRC)
Department MRC Population Health Sciences Research Network (PHSRN)
Country United Kingdom 
Sector Public 
PI Contribution Prof Deary is now a member of MRC Population Health Sciences Research Network representing CCACE. Prof Batty sometimes attends as Deary's deputy
Collaborator Contribution The MRC supports the network.
Impact Deary and Batty have applied to PHSRN for 7.5 thousand ponds to hold a 1-day international meeting on Cognitive Epidemiology: The Next Steps. The plan is for this to be a pre-meeting to the Society for Social Medicine conference in July 2012.
Start Year 2008
 
Description MRC Social and Public-Health Sciences Unit 
Organisation Medical Research Council (MRC)
Department MRC Social & Public Health Sciences Unit
Country United Kingdom 
Sector Public 
PI Contribution MRC Social and Public-Health Sciences Unit, Glasgow, formally collaborates with the CCACE with two of its staff being members of the CCACE. Dr David Batty from the Unit is the cognitive epidemiology group leader in the CCACE and Mr Geoff Der is a full scientific member. Update 2013: David Batty moved to UCL.
Collaborator Contribution Two staff members of the MRC SPHSU are now CCACE scientific members with one holding the role of group leader for cognitive epidemiology.
Impact This formal collaboration is one of the most productive in which the Centre engages. These include: 18235070 18204831 19043147 18525394 18801778 18477751 18594058 18718672 19147741 19189278 19602715 19234402 19344891 18947352 19290736 19907664 19047533 19907663 19572219 18480188 18380686 19047528 19047528 19907333 18812363 19907333 19483120 19861402 19706576 18704700 18655859 19251871 19955099 Roberts et al (2009) Intelligence 37;561-566 19572219 19907663 19955099 18204831 18235070 18477751 18525394 18594058 18718672 18801778 19043147 19047533 19147741 19189278 19234402 1920736 19602715 19468018 20190131 21969461 24747801 24365661 23375947
Start Year 2008
 
Description MRC Unit for Lifelong Health and Ageing 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Public 
PI Contribution The CCACE hosted a cross-Centre meeting with the MRC LHA Centre which resulted in new research collaborations between members of both groups.
Collaborator Contribution Members from both groups are now collaborating on new research.
Impact New research into ageing is being carried out and will be published in the future with one joint paper already published (Richards, M., Black, S., Mishra, G., Gale, C. R., Deary, I. J., & Batty, G. D. (2009). IQ in childhood and the metabolic syndrome in middle-age: extended follow-up of the 1946 British Birth Cohort Study. Intelligence, 37, 567-572). Ian Deary is a formal collaborator on a LHA Wellcome grant. Further publications are already in preparation.
Start Year 2009
 
Description MacLullich - Animal model of delirium 
Organisation Trinity College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution Initiated the work.
Collaborator Contribution Provided advice on research design as well as training of research staff.
Impact None yet.
Start Year 2010
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation Johns Hopkins University
Country United States 
Sector Academic/University 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation NHS Greater Glasgow and Clyde (NHSGGC)
Department Medical Devices Unit
Country United Kingdom 
Sector Public 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation Royal Infirmary of Edinburgh
Department Intensive Care Unit (ICU)
Country United Kingdom 
Sector Hospitals 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation University of Iowa
Country United States 
Sector Academic/University 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description MacLullich - Edinburgh Delirium Test Box 2 
Organisation University of Pennsylvania
Country United States 
Sector Academic/University 
PI Contribution Design of the testing device and tests. Provide advice on testing procedures. Trained two MSc students who helped design the experiment and who carried out the data collection in the ICU.
Collaborator Contribution Implementation of the tests on a bespoke hardware device. The Medical Devices Unit is now going to write new software, which will be MHRA-compliant, for use on tablet PCs and smartphones.
Impact Poster presentation at an international conference (European Delirium Association) on the test. MRC Centenary Fund award, via CCACE, to Dr Zoe Tieges, the postdoctoral fellow working on the EDTB2 programme.
Start Year 2012
 
Description McGue - University of Minnesota 
Organisation University of Minnesota
Department Department of Psychology
Country United States 
Sector Academic/University 
PI Contribution Analysis and report writing.
Collaborator Contribution Twin samples and data.
Impact Publications: Johnson et al (2009) Intelligence 37;466-478; 19290737 19208755 24587224 24337735 23398757
Start Year 2007
 
Description Memory binding functions in patients with amnesia - Mario Parra 
Organisation Marche Polytechnic University
Department Clinical Neurology
Country Italy 
Sector Academic/University 
PI Contribution Developments of new protocols for cognitive assessment of patients with damage to medial temporal lobe structures, training the research personnel in the use of these protocols.
Collaborator Contribution The collaboration has provided facilities and expertise.
Impact One publication and the team are now recruiting data from amnesic patients.
Start Year 2008
 
Description Memory binding in the clinical assessment of MCI - Mario Parra 
Organisation Santa Barbara Cottage Hospital
Country United States 
Sector Hospitals 
PI Contribution Developments of new protocols for cognitive assessment of patients with MCI and older adults.
Collaborator Contribution The collaboration has provided expertise.The collaboration has provided expertise.
Impact This project has received funds from the local institution to carry out a pilot study. We are now defining the protocol and methodology.
Start Year 2010
 
Description Memory binding in the clinical assessment of MCI - Mario Parra 
Organisation University of California, Santa Barbara
Country United States 
Sector Academic/University 
PI Contribution Developments of new protocols for cognitive assessment of patients with MCI and older adults.
Collaborator Contribution The collaboration has provided expertise.The collaboration has provided expertise.
Impact This project has received funds from the local institution to carry out a pilot study. We are now defining the protocol and methodology.
Start Year 2010
 
Description National Forum on Ageing Futures Group 
Organisation National Forum on Ageing Futures Group
Country United Kingdom 
Sector Academic/University 
PI Contribution The Centre's knowledge exchange officer, Dr Robin Morton, approached this group to explain the work of the Centre. They are now extremely interested in collaborating and hearing more on the types of research that the Centre carries out.
Impact Robin Morton has attended one meeting with this group which has raised the profile of the CCACE and the Centre is now known to this group. Ian Deary begin_of_the_skype_highlighting     end_of_the_skype_highlighting gave a keynote presentation at their 2009 national meeting. This was useful as there were many practitioners and policy makers there to hear the work of the Centre.
Start Year 2009
 
Description Network of Centres of Excellence in Neurodegeneration (COEN) 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution MRC Centres of Excellence in Neurodegeneration. Worldwide collaborators in Germany, Italy, France, Canada, USA, Australia and the UK. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Collaborator Contribution International experts in neuro-imaging of ageing, small vessel disease, neurodegeneration and methodology of multimodel MRI across sites.Multiple skill sets of collaborators including small vessel disease; dementia, stroke and brain atrophy; MR physics sequence development for neuroimaging. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Impact COEN grant consortium established standards to SVD across two workshops in 2012. Main paper published 2013. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending.
Start Year 2010
 
Description Network of Centres of Excellence in Neurodegeneration (COEN) 
Organisation University of Calgary
Department Department of Clinical Neurosciences
Country Canada 
Sector Academic/University 
PI Contribution MRC Centres of Excellence in Neurodegeneration. Worldwide collaborators in Germany, Italy, France, Canada, USA, Australia and the UK. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Collaborator Contribution International experts in neuro-imaging of ageing, small vessel disease, neurodegeneration and methodology of multimodel MRI across sites.Multiple skill sets of collaborators including small vessel disease; dementia, stroke and brain atrophy; MR physics sequence development for neuroimaging. Members of the COEN Network are contributing to further secondary analysis of imaging data from the ground-breaking Secondary Prevention of Small Subcortical Stroke (SPS3) trial led by Oscar Benavente (Vancouver, PI, COEN expert), with exchange of fellows between Edinburgh and Vancouver.
Impact COEN grant consortium established standards to SVD across two workshops in 2012. Main paper published 2013. A research fellow from Maastricht (COEN participant van Oostenbrugge) visited Edinburgh and performed further development of individual SVD features into a total sum score. One paper published (see publications) and one paper in review, publication pending.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Normative Brain Image Bank - Ian Deary/ Joanna Wardlaw 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Normative Brain Image Bank: with Aberdeen, Glasgow, Dundee in creation of a normative brain image bank across the life course but specifically for older ages; including external collaboration with UCSF, California (Toga), Montreal Neurological Institute (Evans), Paris (Poline) -JM Wardlaw, M Bastin, I Deary).
Collaborator Contribution The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.The groups have all brought data and expertise to the project.
Impact The project is ongoing with the plan that it will create a bank of brain images. Grant application submitted.
Start Year 2010
 
Description Pendleton - University of Manchester 
Organisation University of Manchester
Department School of Medicine Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of DNA phenotypes, computing, infrastructure, statistical analysis, paper writing.
Collaborator Contribution Subject samples with DNA and cognitive phenotypes
Impact 21826061 24975275 24626473 24344862 24342994 24246418. Plus many talks by Prof Deary and members of the collaboration: including a keynote address by Prof Deary to the International Conference on Alzheimer's Disease in Paris in 2011. Other publications are submitted and in preparation.
Start Year 2008
 
Description Peter Visscher group - University of Queensland 
Organisation University of Queensland
Department Queensland Institute of Medical Research
Country Australia 
Sector Academic/University 
PI Contribution Provided cohorts with phenotypic data and genetic information, plus analysis. This was formally the collaboration with Queensland Institute of Medical Research.
Collaborator Contribution Provided cohorts with phenotypic data and genetics information, plus analysis.
Impact Publications have now arisen: PMIDs: 25249537, 25201988, 23732877, 23419543, 23358156, 23207651, 22832902, 22703881, 22700061, 22258510, 21826061, 1559497, 20303064, 19944402, 19290744, 19077176, 9077115, 18946731, 18493267, 24944428, 24554214, 23732877
Start Year 2008
 
Description Plomin - MRC Social and Developmental and Genetic Psychiatry Centre 
Organisation King's College London
Department MRC Social Genetic and Developmental Psychiatry Centre (SDGP)
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples with genetic and cognitve data, statistical anaysis, writing of papers.
Collaborator Contribution Twin samples with genetic and cognitive data
Impact Publications: 18493267. Prof Plomin from this collaboration is a Co-PI with Prof Deary on the childhood intelligence GWAS consortium. paper: 25224258 25201988 23358156
Start Year 2008
 
Description Prof Carol Brayne University of Cambridge - Alasdair MacLullich 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution New collaboration with Prof Carol Brayne, University of Cambridge, entitled: "The impact of delirium on cognitive and pathological outcomes: elucidating persistent neuroinflammatory effects in population-based cohorts".
Collaborator Contribution The collaboration has brought expertise to the project.
Impact Papers are in preparation.
Start Year 2010
 
Description Prof David Perrett, University of St Andrews - Tim Bates 
Organisation University of St Andrews
Department School of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Professor Tim Bates, CCACE member, is lending his expertise to this collaboration, which forms part of a PhD thesis at University of St Andrews, to derive measures of healthy ageing from skin colour (especially caronenoid levels and blood flow) as well as facial morphology and symmetry.
Collaborator Contribution Expertise
Impact Work in progress
Start Year 2011
 
Description Prof Harald Mischak University of Glasgow 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution We collaborate with Prof. Harald Mischak at the University of Glasgow in 2010 to perform a proteomics study. A paper has been submitted.
Collaborator Contribution Professor Mischak provided expertise.
Impact The following paper has appeared: Lopez et al (2011) Intelligence, 39, 46-53. A grant was submitted to the Dunhill Trust. It was shortlisted but not funded. A further grant is being prepared for the Chief Scientist Office of the Scottish Govenment's health Directorates.
Start Year 2010
 
Description Regional Dementia Network, Milan - Sergio Della Sala 
Organisation Regional Dementia Network Italy
Country Italy 
Sector Charity/Non Profit 
PI Contribution Prof Della Sala has been collaborating with Prof Claudio Mariani as part of the Regional Dementia Network in Milan. This is a joint project on Closing-in on dementia.
Collaborator Contribution Expertise
Impact No outcomes reported.
Start Year 2010
 
Description Risk factors for dementia - Russ 
Organisation University of Tokyo
Country Japan 
Sector Academic/University 
PI Contribution "Geographical variation in and environmental risk factors for dementia in Japan" 2016 - Tokyo University, Japan & Oita University, Japan. Contributions: This work is at a preliminary stage but my Japanese colleagues have agreed to collaborate and provide data; I will analyse these.
Collaborator Contribution Japanese colleagues have agreed to collaborate and provide data
Impact None as yet. Papers are underway.
Start Year 2016
 
Description Roger Watson - Hull University 
Organisation University of Hull
Country United Kingdom 
Sector Academic/University 
PI Contribution Sample data, analysis and co-authorship
Collaborator Contribution Expertise in Mokken Scaling analysis and co-authorship
Impact Publications: 19120753 20492063 20614185 21668542 21779935 21883577
Start Year 2006
 
Description Roger Watson - Hull University 
Organisation University of Sheffield
Department School of Nursing and Midwifery Sheffield
Country United Kingdom 
Sector Academic/University 
PI Contribution Sample data, analysis and co-authorship
Collaborator Contribution Expertise in Mokken Scaling analysis and co-authorship
Impact Publications: 19120753 20492063 20614185 21668542 21779935 21883577
Start Year 2006
 
Description Russ - Geographical variation in dementia in Swedish Twins 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution Using data provided from the Swedish twins registry we are leading on the analyses investigating geographical variation in dementia incidence.
Collaborator Contribution Provide data and expertise.
Impact Papers in preparation.
Start Year 2012
 
Description Russ - Geographical variation in dementia in Swedish Twins 
Organisation University of Southern California
Country United States 
Sector Academic/University 
PI Contribution Using data provided from the Swedish twins registry we are leading on the analyses investigating geographical variation in dementia incidence.
Collaborator Contribution Provide data and expertise.
Impact Papers in preparation.
Start Year 2012
 
Description SPIRIT/SINAPSE - Joanna Wardlaw 
Organisation Bayer
Department Bayer HealthCare
Country Germany 
Sector Private 
PI Contribution GE Healthcare in collaborated project SPIRIT through SINAPSE. "Improved diagnostics for Magnetic Resonance imaging in microvascular stroke and ageing: quantification of brain mineralisation using MR imaging" started in 2010 (ME Bastin, MC Valdés Hernández and JM Wardlaw)
Collaborator Contribution The group provided expertise.
Impact Publication of papers is ongoing.
Start Year 2010
 
Description Scottish Data Linkage and Sharing Service / NRS 
Organisation Government of Scotland
Department Data Sharing and Linkage Service (DSLS)
Country United Kingdom 
Sector Public 
PI Contribution The research team contributed expertise in cognitive epidemiology and feedback on our experiences of data linkage. Ultimately the team will contribute data from the Scottish Mental Survey 1947. The team also suggested a suitable consultant for completion of a scoping project, and hosted and supervised that consultant for the duration of the 3-month project.
Collaborator Contribution The NRS team will contribute linkage between SMS1947 and National Registration 1939 databases. Funds were provided for consultancy work as part of a scoping project to identify suitable databases for linkage.
Impact The linkage between SMS1947 and 1939 national registration databases will enhance the tracing of the SMS1947 group. The scoping project led to the production of an extensive report on the use of the SMS1947 as a 'pathfinder' project for the new Data Sharing and Linkage Service currently under development in Scotland.
Start Year 2013
 
Description Scottish Data Linkage and Sharing Service / NRS 
Organisation National Records of Scotland
Country United Kingdom 
Sector Public 
PI Contribution The research team contributed expertise in cognitive epidemiology and feedback on our experiences of data linkage. Ultimately the team will contribute data from the Scottish Mental Survey 1947. The team also suggested a suitable consultant for completion of a scoping project, and hosted and supervised that consultant for the duration of the 3-month project.
Collaborator Contribution The NRS team will contribute linkage between SMS1947 and National Registration 1939 databases. Funds were provided for consultancy work as part of a scoping project to identify suitable databases for linkage.
Impact The linkage between SMS1947 and 1939 national registration databases will enhance the tracing of the SMS1947 group. The scoping project led to the production of an extensive report on the use of the SMS1947 as a 'pathfinder' project for the new Data Sharing and Linkage Service currently under development in Scotland.
Start Year 2013
 
Description Scottish Dementia Clinical Research Network 
Organisation Alzheimer Scotland
Department Scottish Dementia Clinical Research Network
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CCACE co-Director, Professor John Starr, has formed a collaboration with the Scottish Dementia Clinical Research Network to form a joint CCACE/Alzheimer Scotland Clinical Training Fellowship for Tom Russ who is a CCACE Associate Member. The Centre's contributions and activities with respect to this collaboration can be updated by going to http://www.sdcrn.org.uk/.
Collaborator Contribution Helped put together a Clinical Training Fellowship for a CCACE Associate Member. http://www.sdcrn.org.uk/
Impact The fellowship has begun this year and Centre members through Professor Starr now have easier access to subjetcs with dementia for their research. http://www.sdcrn.org.uk/
Start Year 2009
 
Description Scottish Longitudinal Study / NRS 
Organisation National Records of Scotland
Country United Kingdom 
Sector Public 
PI Contribution Childhood intelligence and family size data from the Scottish Mental Survey 1947 was provided for linkage to data held within the Scottish Longitudinal Study.
Collaborator Contribution Collaborators at the National Records of Scotland are tracing individuals in the Scottish Mental Survey 1947 and locating their 1939 registration number.
Impact This work is ongoing with no reportable outputs to date. The collaboration is multi-disciplinary, involving individuals from psychology, geography, sociology and within the National Records of Scotland.
Start Year 2012
 
Description Scottish Longitudinal Study / NRS 
Organisation University of St Andrews
Department Scottish Longitudinal Study
Country United Kingdom 
Sector Academic/University 
PI Contribution Childhood intelligence and family size data from the Scottish Mental Survey 1947 was provided for linkage to data held within the Scottish Longitudinal Study.
Collaborator Contribution Collaborators at the National Records of Scotland are tracing individuals in the Scottish Mental Survey 1947 and locating their 1939 registration number.
Impact This work is ongoing with no reportable outputs to date. The collaboration is multi-disciplinary, involving individuals from psychology, geography, sociology and within the National Records of Scotland.
Start Year 2012
 
Description Scottish Parliament Cross-Party Group on Older People Age and Ageing 
Organisation Scottish Parliament
Department Scottish Parliament Cross Party Group on Older People Age & Ageing
Country United Kingdom 
Sector Public 
PI Contribution On the basis of its research focus the CCACE was invited to join the Scottish Parliament Cross Party Group on Older People Age and Ageing which discusses Scottish Government policy relating to older adults. The group is convened by Sandra White MSP and George Foulkes MSP. The CCACE knowledge transfer officer, Dr Robin Morton, is the active contact with this group.
Impact The CCACE has attended one meeting of the group to date, and these have continued regularly and future meetings are in Prof Deary's diary. At the last meeting in August 2011, Prof Deary made a presentation on the work of CCACE to Scottish MSPs and leading members of ageing charities in Scotland.
Start Year 2009
 
Description Sfc Brain Research Imaging Centre (SBIRC) 
Organisation University of Edinburgh
Department Brain Research Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution The SBIRC is the organisation which is responsible for housing the expertise and data management related to brain imaging of the LBC 1936. The CCACE database manager, Mr Dave Liewald, has formed a working partnership with the SBIRC team to write software for a new database for collecting brain imaging clinical data.
Impact This is a key collaborative group with which the Centre works and many joint publications related to brain imaging aspects of cognitive ageing have appeared, as listed below. Dave Liewald developed a software prototype for this group which has now been fully tested. 17624630 18931002 19095989 19451533 17869382 18690455 19344368 17719145 18340104 19536582 19346327 18931005 19131659 19850898 18617668 19064881 19213950 19341481 19211227 18309161 19260033
Start Year 2009
 
Description Shenkin - BraINS (Brain Imaging in Normal Subjects) 
Organisation University of Edinburgh
Department Brain Research Imaging Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution collaboration with multidisciplinary staff in Scottish Brain Imaging Centre (SBIRC) (neuroradiologists, image data managers, information technologists) to develop a searchable bank of normal brain images collected from previous research studies (several conducted by members of CCACE in geriatric medicine, psychology and psychiatry). No funding at present (application to CSO rejected, but encouraged international collaboration to set up resource).
Collaborator Contribution As above.
Impact No outputs yet. Aim is to develop a searchable database, and ultimately expand to an international, on-line, searchable resource.
Start Year 2011
 
Description Shenkin - Dementia and Delirium Implementation Group 
Organisation NHS Lothian
Department Geriatric Medicine
Country United Kingdom 
Sector Hospitals 
PI Contribution Member of Dementia and Delirium Implementation Group (NHS Lothian, UK) since 2009. Working towards improving the care of patients with dementia and delirium in NHS Lothian using audit, education and patient experience.
Collaborator Contribution Member of a working group.
Impact Documentation of diagnosis of dementia and delirium has improved. Delirium screening embedded in new admission document.
Start Year 2009
 
Description Shenkin - Lothian Dementia Strategy Implementation and Monitoring Group 
Organisation NHS Lothian
Department Geriatric Medicine
Country United Kingdom 
Sector Hospitals 
PI Contribution Group member.
Collaborator Contribution Developing and implementing strategy to improve care of patients with dementia in community and hospital.
Impact Improve care of dementia patients.
Start Year 2010
 
Description Sherif Karama - McGill University, Montreal 
Organisation McGill University
Department Montreal Neurological Institute and Hospital
Country Canada 
Sector Hospitals 
PI Contribution We provided brain imaging data and cognitive phenotypes.
Collaborator Contribution They analysed our brain imaging data for brain cortical thickness and conducted statistical analyses.
Impact Published papers and papers in progress. Pub med IDs: 23732878, 21241809
Start Year 2008
 
Description Software Sustainability Institute (SSI) 
Organisation University of Edinburgh
Department UK Software Sustainability Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborative project to devise a sustainability plan for the release, support, maintenance and ongoing development of MCMxxxVI (MC Valdés Hernández and JM Wardlaw)
Collaborator Contribution Devise a sustainability plan for the release, support, maintenance and ongoing development of MCMxxxVI.
Impact Sustainable cataloged software for other academics to use, will be available online soon.
Start Year 2010
 
Description Study of memory binding functions in a genetic variant of AD and APOE-4 carriers - Mario Parra 
Organisation University of Antioquia
Country Colombia 
Sector Academic/University 
PI Contribution We have introduced a new methodology in the assessment of Alzheimer's diseases (AD). This methodology has allowed us to characterise early cognitive deficits in a familial variant of AD.
Collaborator Contribution The collaboration has provided facilities and expertise.
Impact Publication 5 in the list above. Our protocol has been now adopted as a standard assessment method for all the referrals entering the centre database. This protocol is also being used in the preparation of clinical trials aimed at introducing anti-amyloid preventive therapies in familial AD.
Start Year 2007
 
Description Telomere Phenomics Consortium 
Organisation Telomere Consortium
Country Global 
Sector Academic/University 
PI Contribution The Telomere Phenomics Consortium aims to enhance the quality of the evidence relating (or not) telomere length to cardiovascular risk factors and cardiovascular/overall outcome by combining data from high quality studies which share phenotypes, beyond initial publications of such data. The aim is not to compete against or supersede such primary publications but to subsequently reinforce findings through meta-analysis. The Lothian Birth Cohort 1936 data which is held in Edinburgh has been added to this consortium. The CCACE geneticist, Dr Sarah Harris, leads this collaboration.
Collaborator Contribution They have brought data and expertise.
Impact Data across Centres are being amalgamated and joint analyses are currently being completed.
Start Year 2008
 
Description Thomson - DISC1 study 
Organisation Cold Spring Harbor Laboratory (CSHL)
Country United States 
Sector Charity/Non Profit 
PI Contribution We are using next generation sequencing technology to resequence ~260 genes that are known protein-protein interactors of DISC1, or are altered in expression studies of DISC1, in approximately 2000 individuals (including LBC1936). This project is funded by a 2007 grant to Cold Spring Harbor Laboratory. The collaboration involves both DNA sequencing, bioinformatic and statistical expertise. Variants identified in this resequencing project have been analysed for association with mental illness, cognition and cognitive aging. This project is covered by a material transfer agreement.
Collaborator Contribution As above.
Impact Research papers.
Start Year 2007
 
Description Thomson - DISC1 study 
Organisation University of Queensland
Department Queensland Institute of Medical Research
Country Australia 
Sector Academic/University 
PI Contribution We are using next generation sequencing technology to resequence ~260 genes that are known protein-protein interactors of DISC1, or are altered in expression studies of DISC1, in approximately 2000 individuals (including LBC1936). This project is funded by a 2007 grant to Cold Spring Harbor Laboratory. The collaboration involves both DNA sequencing, bioinformatic and statistical expertise. Variants identified in this resequencing project have been analysed for association with mental illness, cognition and cognitive aging. This project is covered by a material transfer agreement.
Collaborator Contribution As above.
Impact Research papers.
Start Year 2007
 
Description Toshiba Medical Visualisation Systems 
Organisation Toshiba Medical Visualisation Systems
Country United Kingdom 
Sector Private 
PI Contribution - Supervising student project on a comparison of 4 unsupervised clustering algorithms for segmenting brain tissue in multi-spectral MR data. - Discussions are ongoing with Toshiba Medical Visualisation Systems regarding development of normative brain atlases and potential development of image processing tools.
Collaborator Contribution - Plans to develop normative brain atlases and potentially image processing tools. - ED student of the Institute for System Level Integration collaboratinmg for 2x8 weeks
Impact Talk at BIOSTEC 2010 (Third International Joint Conference on Biomedical Engineering Systems and Technologies).
Start Year 2008
 
Description Toshiba Medical Visualisation Systems - Joanna Wardlaw 
Organisation Toshiba Medical Visualisation Systems
Country United Kingdom 
Sector Private 
PI Contribution Toshiba Medical Visualisation Systems (TMVS) in collaborated projects through SINAPSE. "Neuroimage processing tools for studies of brain ageing" started in 2008 (MC Valdés Hernández and JM Wardlaw)
Collaborator Contribution They brought expertise to the group.
Impact Projects are currently ongoing.
Start Year 2008
 
Description UK Biobank 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution We provide statistical analysis and expertise on the cognitive and personality associated variables in a large collaboration aimed at studying associations between behavioural and medical outcomes in UK Biobank.
Collaborator Contribution They provide expertise in epidemiology and psychiatric disorders.
Impact Publications: 24884621, 24336235 , 24282498
Start Year 2013
 
Description UK Dementia Platform 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample.
Collaborator Contribution As above.
Impact This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award.
Start Year 2013
 
Description UK Dementia Platform 
Organisation Johnson & Johnson
Country United States 
Sector Private 
PI Contribution Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample.
Collaborator Contribution As above.
Impact This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award.
Start Year 2013
 
Description UK Dementia Platform 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample.
Collaborator Contribution As above.
Impact This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award.
Start Year 2013
 
Description UK Dementia Platform 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample.
Collaborator Contribution As above.
Impact This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award.
Start Year 2013
 
Description UK Dementia Platform 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Ian Deary is on the Executive Committee and the Scientific Steering Group of the UK dementias platform, which has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award. Also, from CCACE, John Starr, Jean Manson and Cathie Sudlow are on the scientific steering committee. Ian Deary and John Starr lead a work package which relates to enhancing cognitive testing in the UK Biobank sample in order to make it a dementia-ready cohort. Cathie Sudlow leads a work package which is aiming to conduct ascertainment of dementia in the UK Biobank sample.
Collaborator Contribution As above.
Impact This collaboration has attracted about £12million of core funding and has already added to that with about £40m in the MRC's clinical research infrastructure award.
Start Year 2013
 
Description Understanding memory binding functions in individuals at risk for developing AD such as those with MCI and also healthy older adults - Mario Parra 
Organisation Complutense University of Madrid
Country Spain 
Sector Academic/University 
PI Contribution Developments of new protocol for cognitive assessment in healthy and pathological ageing, training the research personnel in the use of these protocols, visits to our collaborators to deliver talks, training and data analysis.
Collaborator Contribution Use of facilities and expertise.
Impact Work in progress.
Start Year 2009
 
Description University of Ancona - Sergio Della Sala 
Organisation University of Ancona
Country Italy 
Sector Academic/University 
PI Contribution Prof Della Sala has been collaborating with Prof. Leandro Provinciali of University of Ancona, Italy on memory binding in AD. Prof Della Sala and his team have through their own research endeavours developed cognitive tests of memory binding, which may have clinical utility in the assessment and diagnosis of AD.
Collaborator Contribution Expertise
Impact A number of papers have been submitted for publication.
Start Year 2010
 
Description University of Antioquia, Columbia - Sergio Della Sala 
Organisation University of Antioquia
Country Colombia 
Sector Academic/University 
PI Contribution Prof Della Sala has collaborated with Dr Francisco Lopera of the University of Antiochia in Columbia, on research in to memory binding in familial Alzheimer's Disease. Prof Della Sala brings expertise in the memory binding assessments in AD.
Collaborator Contribution Expertise
Impact This has resulted in paper which have been submitted for publication.
Start Year 2010
 
Description University of Bonn - Germany 
Organisation University of Bonn
Department Department of Psychiatry
Country Germany 
Sector Academic/University 
PI Contribution Dr Mario Parra, a CCACE member, is the Edinburgh collaborator on this study: "A longitudinal multicenter study aimed at the detection, deep phenotyping, and follow-up of prodromal AD subjects including Amyloid PET, CSF, MRI and Memory Binding tasks". The study is called DELCODE (Longitudinal Cognitive Impairment and Dementia Study). It will include 400 subjects with memory complaints only (subjective memory impairment), 200 subjects with early or late MCI, 200 siblings of AD patients, 200 controls, and 100 patients with AD. It will last 3 years, and all subjects will be followed up for 5 years with annual examinations. This study is strongly funded by the new DZNE in Bonn. This research team will contribute to expertise, recruitment and assessment.
Collaborator Contribution Expertise, recruitment of patients and controls with mild cognitive impairment, and cognitive and neuroimaging assessment.
Impact Dr Parra is visiting the partners at the University of Bonn in December 2011. The protocol has been completed, and this visit will be used to speak to the group and start the data collection.
Start Year 2011
 
Description University of Copenhagen - Alan Gow 
Organisation Heriot-Watt University
Department Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Alan Gow, CCACE associate member, was guest professor in a programme collaboration with the Center for Healthy Aging in Copenhagen. He provided his expertise in working on longitudinal cohort studies in cognitive ageing, using the Glostrup 1914 cohort. He has visited three times, in 2011, 2012 and 2013. Further visits are planned for November 2014 and June-July 2015.
Collaborator Contribution Expertise, data and use of Center facilities
Impact The collaboration resulted in 3 published papers, with an additional paper in preparation: Gow, A. J., Mortensen, E. L., & Avlund, K. (2012). Activity participation and cognitive aging from age 50 to 80 in the Glostrup 1914 Cohort. Journal of the American Geriatrics Society, 60, 1831-1838. Gow, A. J., Avlund, K., & Mortensen, E. L. (2014). Occupational characteristics and cognitive aging in the Glostrup 1914 Cohort. The Journals of Gerontology, Series B: Psychological Sciences, 69, 228-236. Gow, A. J., Avlund, K., & Mortensen, E. L. (2014). Leisure activity associated with cognitive ability level, but not cognitive change. Frontiers in Psychology, doi: 10.3389/fpsyg.2014.01176. Gow, A. J., Mortensen, E. L. & Avlund. K. (in preparation). Social resources and cognitive aging across thirty years: the Glostrup 1914 Cohort.
Start Year 2011
 
Description University of Copenhagen - Alan Gow 
Organisation University of Copenhagen
Department Center for Healthy Aging
Country Denmark 
Sector Academic/University 
PI Contribution Dr Alan Gow, CCACE associate member, was guest professor in a programme collaboration with the Center for Healthy Aging in Copenhagen. He provided his expertise in working on longitudinal cohort studies in cognitive ageing, using the Glostrup 1914 cohort. He has visited three times, in 2011, 2012 and 2013. Further visits are planned for November 2014 and June-July 2015.
Collaborator Contribution Expertise, data and use of Center facilities
Impact The collaboration resulted in 3 published papers, with an additional paper in preparation: Gow, A. J., Mortensen, E. L., & Avlund, K. (2012). Activity participation and cognitive aging from age 50 to 80 in the Glostrup 1914 Cohort. Journal of the American Geriatrics Society, 60, 1831-1838. Gow, A. J., Avlund, K., & Mortensen, E. L. (2014). Occupational characteristics and cognitive aging in the Glostrup 1914 Cohort. The Journals of Gerontology, Series B: Psychological Sciences, 69, 228-236. Gow, A. J., Avlund, K., & Mortensen, E. L. (2014). Leisure activity associated with cognitive ability level, but not cognitive change. Frontiers in Psychology, doi: 10.3389/fpsyg.2014.01176. Gow, A. J., Mortensen, E. L. & Avlund. K. (in preparation). Social resources and cognitive aging across thirty years: the Glostrup 1914 Cohort.
Start Year 2011
 
Description University of Dundee - Karen Horsburgh 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Dr Karen Hosburgh, a CCACE research member, contributes to this collborative study titled: "Effect of hypertension and high fat diet on structural integrity in the ageing brain". This collaboration harnesses her expertise and those of her research team, to study the underlying pathophysiology of vascular disease in experimental models with those at the University of Dundee in assessing metabolic changes. This work also links to a CCACE imaging award to Horsburgh K (with Drs Holland, Bastin and Prof Wardlaw, University of Edinburgh) in developing imaging approaches to assess white matter changes in a hypertensive model ("Effect of hypertension and high fat diet on structural integrity in the ageing brain: parallel imaging and pathology").
Collaborator Contribution Expertise and data
Impact These studies are underway and publications arising form this work are expected 2012/2013. The work is multidisciplinary and involves basic researchers in neuroscience, biochemistry and clinical radiology
Start Year 2011
 
Description University of Newcastle 
Organisation Newcastle University
Department Ear, Nose and Throat Department
Country United Kingdom 
Sector Academic/University 
PI Contribution Psychometric expertise, analysis and co-authorship. In addition to the ENT departmetn we also collaborate with the Centre for Brain Ageing and Vitality.
Collaborator Contribution Data on ENT patients and co-authorship
Impact Publications: 20004302. In addition we have had shared PHD retreats with the CBAV, and Deary co-supervisors as PhD student (Heather Moore) from CBAV.
 
Description University of Oslo 
Organisation University of Oslo
Department Department of Psychology
Country Norway 
Sector Academic/University 
PI Contribution Together the team has contributed gentoyping and cognitive phenotyping information on their respective cohorts to contribute to joint publicaitons and to make future plans for genetics studies and cognitive and brain ageing.
Collaborator Contribution This is a collaboration with the University of Oslo in bringing together an international group based in the Centre for Advanced Study in Oslo, Norway. The Oslo collaborators provided travel and subsistance for the Edinburgh team and also some funding for post-doctoral staff wages (still to be drawn).
Impact Davies et al (2011) Molecular Psychiatry, 16, 996-1005. Also, workshops in Bergen and Oslo in 2011, with further meetings planned for 2012. Post-doctoral exchange visits have taken place and are planned.
Start Year 2008
 
Description University of Oslo - Alasdair MacLullich 
Organisation University of Oslo
Country Norway 
Sector Academic/University 
PI Contribution Professor Alasdair MacLullich, group leader of of Stress, Hormones and Cognitive Ageing research at CCACE, along with Dr Roanna Hall (CCACE member) and colleagues, have contributed advice on delirium neuropsychology and assessment for a Clonidine study, which is due to commence. The research team have also sent aliquots of CSF and serum for measurement of biomarkers in Oslo. The researchers are exploring two areas: (1) Cerebrospinal fluid studies in delirium after hip fracture, and, (2) Clonidine for delirium after hip fracture.
Collaborator Contribution They have sent CSF and serum data to Edinburgh for examination of biomarkers.
Impact This has so far resulted in a series of poster presentations at the American Delirium Society Inaugural conference in June 2011, and soon to a series of publications reporting these results. Talks and posters at international conferences (eg. International Psychogeriatrics Association, The Hague 2011; American Delirium Society, Indianapolis 2011; European Union Geriatric Medicine Society annual meeting 2011); papers are forthcoming. The collaborationis multi-disciplinary involving geriatricians, psychiatrists, pharmacists and biochemists.
Start Year 2011
 
Description University of Osnabrück - Sergio Della Sala 
Organisation University of Osnabrück
Country Germany 
Sector Academic/University 
PI Contribution Prof Della Sala has collaborated with Dr. Reiner Kashel of the University of Osnabrück, Germany, on dual-task performance in patients with AD, MCI and chronic depression. Prof Della Sala and his research team have developed cognitive assessments of dual-task performance, for their diagnostic utility in AD.
Collaborator Contribution Expertise
Impact Several papers have been submitted following this collaboration. The first has been published in Archives of Clinical Neuropsychology: 21576091
Start Year 2010
 
Description University of Queensland - genome-wide methylation study 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution LBC1936 and LBC1921 DNA samples were typed using the Illumina HumanMethylation450 BeadChip at the Wellcome Trust Clinical Research Facility (WTCRF). Quality control of the data was performed at the University of Queensland and analyses are ongoing at both CCACE and the University of Queensland.
Collaborator Contribution See above. Quality control of the data was performed at the University of Queensland.
Impact The following paper has been published: Shah S, McRae AF, Marioni RE, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Starr JM, Wray NR, Deary IJ, Visscher PM. (2014). Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Res doi:10.1101/gr.176933.114.
Start Year 2012
 
Description University of Tblisi - Sergio Della Sala 
Organisation Tbilisi State Medical University
Country Georgia 
Sector Academic/University 
PI Contribution Prof Della Sala has been collaborating with Dr. Kate Inasaridze of the University of Tblis, Georgia on studies of dual-task performance in dementias. Prof Della Sala's team have developed dual-task performance measures for clinical and research use.
Collaborator Contribution Expertise
Impact Papers resulting from this collaboration have been submitted for publication.
Start Year 2010
 
Description University of Trento - Sergio Della Sala 
Organisation University of Trento
Country Italy 
Sector Academic/University 
PI Contribution CCACE member Prof Della Sala has been collaborating with Prof R Cubelli of University of Trento, combining expertise in neuropsychological assessment
Collaborator Contribution Expertise
Impact A number of peer-review publications have resulted from the collaboration in 2011: 20181331 21333286 21557004 And: Cubelli, R. & Della Sala, S. (2011) The Purposes of Neuropsychological Assessment and How to Achieve Them. Advances in Clinical Neuroscience & Rehabilitation (ACNR), 11 (1), 36-37. Cubelli, R., Beschin, N. & Della Sala, S. (2011) Neuropsicologia clinica: scopi e metodi. Link, 17, 55-58.
Start Year 2010
 
Description Whalley - University of Aberdeen 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Study design, analysis, and co-authorship
Collaborator Contribution Aberdeen Birth Cohort samples and a range of expertise
Impact Co-hosting of Centre seminar on Imaging in Healthy and Pathological Ageing. Publications: 19910296 18071924 18258638 18395472 18783620 20593030 20398148 21225350 21297868 21346712 21349224 21424787 21700406 21749994 21826061 21859598 22045296 24626473 24399044 24246418 23625136
Start Year 2006
 
Title A Tiny Handbook of R 
Description CCACE Statistician has written "A Tiny Handbook or R", which was published by Springer in 2011. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2011
Licensed Yes
Impact The book has achieved sales of over 170 copies since publication in April 2011. Sample pages from the handbook, published on the Springer website, have been downloaded 634 times in the last 90 days. The handbook is also being used in a course on Data Analysis, Forecasting and Risk Analysis in Washington University in St Louis.
 
Title DelApp - Tieges 
Description The software source code for the current prototype of the DelApp has been written by Lothian NHS co-investigators on the project. The source code is protected by copyright. 
IP Reference  
Protection Copyrighted (e.g. software)
Year Protection Granted 2016
Licensed No
Impact This software has led to the development of potential clinical tool: DelApp. This is a software test for detecting attentional deficits in delirium [at the validation stage]. The value of the DelApp study was recognised in the oral presentation prize being awarded at the European Delirium Association meeting in November 2016.
 
Title Delbox versions 1 and 2 - Alasdair MacLullich 
Description A patent has been filed for a new computerised instrument for the detection of attentional deficits in delirium (the "Delbox"). The University of Edinburgh has filed a patent to cover the key features of the DelApp test and patents have now been granted in the US and in Europe: US 9307940 'Apparatus and Methods for testing sustained attention and Delirium'; EP 2485645 'Testing Apparatus and Method'. Key data informing the patents were provided from the original, smaller MRC Developmental Pathway Finding Scheme (DPFS) grant (Delbox), and our current studies' results are consistent with these findings, strengthening the claims. 
IP Reference EP2485645 (Europe) US9307940 (US) 
Protection Patent granted
Year Protection Granted 2016
Licensed No
Impact The 'Delbox' mark 2 has now been developed as a result of an MRC Development Pathway Funding Scheme grant and is currently being tested on patients and volunteers, some of whom are accessed using CCACE resources. It has attracted interest from research groups outwith Edinburgh and once we have completed the validation work over the next few months we will make it commercially available. This process is still ongoing.
 
Title Physical testing instruction DVD 
Description Production of "A physical testing instruction DVD with Introduction to the 6-Day Sample by Professor Ian Deary". This contains a short film (c.30 minutes) showing detailed instructions for completion of the physical testing portion of the 6-Day Sample study. 
IP Reference  
Protection Protection not required
Year Protection Granted 2012
Licensed No
Impact The video has been shared via the CCACE You Tube channel and has been viewed 101 times. Participants in the study have found it useful in helping them to complete the physical testing requirements.
 
Title Deary-Liewald Reaction Time Task 
Description Developed by CCACE Director, Professor Ian Deary, and CCACE database manager, Mr Dave Liewald, a newly developed computerised reaction time task will be made freely available via the CCACE website. The computer programme includes a simple reaction time task, in which the participant has to respond to a single stimulus, and a four choice reaction time task, in which the participant has to chose from four possible responses. In 2011 CCACE developed and published an updated version (v3.10) with additional features to enhance its usability. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Under active development/distribution
Impact Since 2011 the device has been made freely available on the CCACE website: www.ccace.ed.ac.uk. The programme has received >170 Downloads and is in routine use as a research tool in a number of centres globally. In Scotland, it is being used in the population-based study Generation Scotland: Scottish Family Health Study and in the Edinburgh Type II Diabetes Study. 
URL http://www.ccace.ed.ac.uk
 
Title Delbox - Alasdair MacLullich 
Description A prototype computerised neuropsychological testing device for the detection of attentional deficits in delirium, entitled the "Delbox" was developed and tested in 2007. CCACE scientists have collaborated on a successful grant application for the development of the next stage of this device (see section 3). This grant (£150,000 from the MRC Development Pathway Funding Scheme) has now been awarded. The prototype device is known as the 'Delbox'. A paper in JNNP in June 2010 was published on the basis of this work. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact The Centre has been awarded funding to further the development of the device. The Delbox was used as part of a successful MSc Cognitive Neuropsychology (Edinburgh) project (Amanda Robertson: distinction grade in the project and overall; oral presentation at the European Delirium Association meeting in Nov 2010; forthcoming manuscript). The Delbox is also being used by Dr Roanna Hall in her Clinical Research Fellowship and new data demonstrating the utility of the Delbox in detecting and monitoring delirium were the subject of an oral presentation at the European Delirium Association annual meetingin Nov 2010. The team contiue make use of CCACE resources to access volunteers for studies with the Edinburgh Delirium Test Boxes. 
 
Title MCMxxxVI Imaging Software - Maria Valdes Hernandez 
Description Maria Valdes Hernandez (CCACE member) has developed a new imaging software package. MCMxxxVI (1936) is a new versatile automatic technique for measuring volume biomarkers in the ageing brain. 
Type Support Tool - For Fundamental Research
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact The software is open source and available for downloading from www.sbirc.ed.ac.uk under the Apache License version 2.0, Jan 2004. 
URL http://www.sbirc.ed.ac.uk
 
Title Deary-Liewald Reaction Time Task - Ian Deary, Dave Liewald 
Description Developed by CCACE Director, Professor Ian Deary, and CCACE database manager, Mr Dave Liewald, a newly developed computerised reaction time task is freely available via the CCACE website. The computer programme includes a simple reaction time task, in which the participant has to respond to a single stimulus, and a four choice reaction time task, in which the participant has to chose from four possible responses. A child version of reaction time task has recently been developed and used in the Edinburgh Science Festival. 
Type Of Technology Software 
Year Produced 2009 
Open Source License? Yes  
Impact The device is being used by the large population study Generation Scotland: Scottish Family Health Study. A paper describing the methodology is now in press. In 2011 CCACE developed and published an updated version (v3.10) with additional features to enhance its usability. The programme has received several hundred downloads and is in routine use as a research tool in a number of centres globally. In Scotland, it is being used in the population-based study Generation Scotland: Scottish Family Health Study and in the Edinburgh Type II Diabetes Study. Mr Jack Nissan, CCACE's Human Testing Technician provides training of this research tool to the cohort studies. 
 
Title Iron Deposits Segmentation Guidlines 
Description Detailed guidelines (manual) to use the software package Analyze 9.0 to identify and quantify brain microbleeds and hemosiderin deposits in T2*-weighted MR sequences. Uploaded to the internet in December 2009. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2009 
Impact Novel MRI analysis tool, suitable for large samples. 
 
Title Liewald-Cox Heatmapper - Dave Liewald, Simon Cox 
Description Developed by the CCACE database manager Dave Liewald and CCACE Associate Simon Cox, the Heatmapper tool allows the quick and simple creation of high resolution figures to illustrate associations between variables of interest and sub-regions of the brain's cortex. 
Type Of Technology Software 
Year Produced 2016 
Open Source License? Yes  
Impact Beta version will be released in Spring 2016, and the first outputs are part of a publication in preparation: Cox SR, Bastin ME, Ritchie SJ, Dicke DA, Liewald DC, Munoz Maniega S, Redmond P, Royle NA, Pattie A, Valdes Hernandez MdelC, Corley J, Aribisala BS, McIntosh AM, Wardlaw JM, Deary IJ. Brain cortical characteristics of lifetime cognitive ageing. It will also be used to illustrate the results of future cortical analyses conducted by CCACE members in both the LBC and UK Biobank cohorts, and also used more widely by other researchers once it becomes available via the CCACE website. 
 
Title R package to implement Thomson's bonds model 
Description The Centre's statistician, Dr Mike Allerhand, developed an R package in order to implement the Bonds theory of intelligence first proposed by Godfrey Thomson. It has been described in: Bartholomew D. J, Allerhand M., Deary I. J., (2013). Measuring mental capacity: Thomson's bonds model and Spearman's g-model compared. Intelligence. 41:222-233. 
Type Of Technology Software 
Year Produced 2013 
Open Source License? Yes  
Impact The package is distributed open source through the Centre's website. 
 
Title Reference Tracts and Generative Models for Brain White Matter Tractography 
Description These were created and presented at Medical Image Understanding and Analysis: 21st Annual Conference, 2017, and the citation is the first paper above. These reference tracts improved the automatic segmentation of brain white matter tracts from diffusion MRI, and demonstrated that matching models can be successfully transferred to novel data. The availability of these tracts and models make the use of probabilistic neighborhood tractography in small testing datasets possible as it can bypass the need for training data. They have been made available through the "TractoR MRI analysis project" (http://www.tractor-mri.org.uk). TractoR is free soft­ware, avail­able un­der the GPL li­cence. The reference tracts are referred to in here http://www.tractor-mri.org.uk/reference-tracts. 
Type Of Technology Webtool/Application 
Year Produced 2017 
Open Source License? Yes  
Impact The availability of these tracts and models make the use of probabilistic neighborhood tractography in small testing datasets possible as it can bypass the need for training data. 
URL http://www.tractor-mri.org.uk
 
Title Software MCMxxxVI 
Description This software implements the Multispectral Colouring Modulation and Variance Identification method developed in the SFC Brain Image Research Centre for doing the Tissue Segmentation and Volume Analysis in MR images and incorporates some post-processing tools important for displaying and calculating the statistics of the features segmented. Four modules were uploaded to the internet in December 2009 (as open source software). 
Type Of Technology Software 
Year Produced 2009 
Open Source License? Yes  
Impact Novel MRI analysis technique, suitable for large samples. 
 
Company Name NeurocentRx Pharma Ltd 
Description NeurocentRx Pharma Ltd.™ was founded in 2008 by 14 academics with renowned scientific and clinical teams from the University of Edinburgh, with Dr Ron Lindsay (Regeneron, Millennium) as Chairman, Dr Howard Marriage (Genzyme, Cyclacel) as CEO, and with key pharma / biotech business veteran advisors. NeurocentRx™ aims to be an innovative company that will harness the translational insight of the University's leading researchers to enhance the development of neuroscience medicines in the key areas of cognition, psychiatry and pain. Leading scientific insight is provided by the internationally renowned academic teams of Professors Jonathan Seckl (CCACE co-Director), David Porteous (CCACE Group Leader), Douglas Blackwood, Sue Fleetwood-Walker and Malcolm Walkinshaw. The NeurocentRx starting structure provides opportunities for multiple possible academic and partnering interactions and involvements in an open architecture model that seeks to match the best early projects with enthusiasm to the best available and experienced care. 
Year Established 2008 
Impact 1) Initial Portfolio in Psychiatry, Pain & Cognition, New Drug Targets For Schizophrenia Prof. David Porteous (CCACE Group Leader), Prof. Douglas Blackwood, Dr. Walter Muir, Dr. Ben Pickard Discovery and Validation Stage - DISC-1 Gene and Down Stream Targets Human genetics driven discovery and validation stage project - World class and well funded academic project to define the molecular basis of schizophrenia through population genetic studies in Scotland. Project lead by Prof David Porteous & Douglas Blackwood has already lead to identification (and wide publicity) of the first gene defect associated with schizophrenia - DISC 1. Working closely with this group, NeurocentRx plans to make this a flagship discovery and target validation project that will be the centerpiece of a major collaborative program with a global Pharma company. 2) Novel Validated Target for Neuropathic Pain Prof. Susan Fleetwood-Walker, Prof. Marie Fallon, Prof. Lesley Colvin, Dr. Rory Mitchell, Dr. Mike Greaney Preclinical Stage and clinical - Small Molecule Agonists of TRP-M8 Lead molecule validated in animal models - Based on a seminal discovery of Prof. Fleetwood- Walker and colleagues, it appears that activation of the non-selective cation channel TRP-M8 may be something of master switch in quelling chronic neuropathic pain (pain associated with direct nerve damage such as injury, diabetes, surgery etc) . An analgesia program based on TRP-M8 and possibly other pain targets, will be the initial internal centerpiece of an internal pain program at NeurocentRx. 3) New Approach for the Treatment of Cognitive Disorders Prof. Jonathan Seckl (CCACE co-Director)) & Prof. Alasdair MacLullich (CCACE Group Leader) Pre-IND Stage - Inhibitors of 11beta HSD1 - Use of Off-Patent Drug with Follow-On Potential 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an intracellular amplifier of glucocorticoid action. By converting intrinsically inert glucocorticoids (cortisone, 11-dehydrocorticosterone) into their active forms (cortisol, corticosterone), 11beta-HSD1 increases glucocorticoid access to receptors. Glucocorticoid hormones modulate diverse physiological processes, linking circadian rhythms to food seeking, motivational and cognitive behaviors, as well as intermediary metabolism and immune responses. A novel clinical trial program is being designed that may, be a forerunner for testing an existing class of drug in an acute cognitive impairment setting prior to trials in Alzheimer's disease.
 
Description "Financial Abuse of Older People" - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact February 18 2016: took part in a seminar on Financial Abuse of Older People at Age UK, alongside members of the police, policymakers, and charity workers.
Year(s) Of Engagement Activity 2016
 
Description 'AgeWell' annual event - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact September 1 2016: gave a talk on the LBC1936 to the 'AgeWell' annual event (general public audience) at the University of Birmingham.
Year(s) Of Engagement Activity 2016
 
Description A Day in the Life of Edinburgh Neuroscience 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact CCACE also collaborated with Edinburgh Neuroscience on a short film Ages of the Brain: a Day in the Life of Edinburgh Neuroscience. Using film and sound clips submitted by research groups from across CCACE and Edinburgh Neuroscience, we put together a short film on the variety of Neuroscience research across Edinburgh, with a special emphasis on the ageing brain. The film premiered at a joint event on 30 June and has since been viewed on YouTube over 1,400 times (https://youtu.be/zQqIH5yY3-c).
Year(s) Of Engagement Activity 2015
URL https://youtu.be/zQqIH5yY3-c
 
Description Adam Smith Institute's 'Forum' event - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact December 3 2016: gave a talk on intelligence generally, including LBC1936 data, for the Adam Smith Institute's 'Forum' event (audience: general public).
Year(s) Of Engagement Activity 2016
 
Description Age UK Bake Sale 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact CCACE core staff and members help a bake sale in aid of Age UK in February 2016. The charity event was held in the Department of Psychology and was open to anyone who wanted to buy. Prizes were awarded for the cake that best linked to an area of research or study, and the most amusing design.
Year(s) Of Engagement Activity 2017
 
Description Age UK Disconnected Mind Internal Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Presentations given by Drs Cox, Ritchie and Morton and Prof Deary to Age UK staff from across the organisation about study findings. This was followed by breakout sessions to discuss how the findings can be incorporated into Age UK practices. January 2015
Year(s) Of Engagement Activity 2015
 
Description Age UK For Later Life Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact This is the annual conference of the UK's largest charity devoted to helping older people, Age UK. Professor Deary addressed the whole meeting on the topic of healthy cognitive ageing, ensuring a broad UK reach to workers in the older-age charity sector.
Year(s) Of Engagement Activity 2015
 
Description Age UK Symposium on Financial Abuse 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Stuart Ritchie contributed to a panel discussion/symposium held at Age UK in London in February 2016 on financial abuse of older people. The panel included representatives from Age UK, the Metropolitan Police, banks (HSBC, Santander, Lloyd's), and other academics. Dr Ritchie used research findings from the Lothian Birth Cohorts to discuss how age-related cognitive decline might increase vulnerability to financial abuse in older persons.
Year(s) Of Engagement Activity 2016
 
Description Age UK staff on LBC1936 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Age UK is one of the main founders of Professor Deary's Lothian Birth Cohorts projects on healthy cognitive ageing. This talk was one of a number given by Professor Deary and team members to a large number of workers at Age UK in order to bring them up to date with the aims, findings, and practical applications of the teams research on cognitive ageing. It is used by Age UK in order to produce information, including books and website information, on the risks and protective factors for normal cognitive ageing which is highly important for their members.
Year(s) Of Engagement Activity 2015
 
Description Artist collaboration - "The Strategy of the Genes" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The artwork is made by Penelope Kay, Artist in Residence at the invitation of Prof. Andrew McIntosh. The concept for the artwork is inspired by Dr. Pippa Thomson, Lecturer in Psychiatric Genetics and Group Leader at the Institute of Genetics and Molecular Medicine (IGMM), Edinburgh.
The art project involves creating a 3D object that can be installed in either an art or science space and can be interacted with by the viewer, who might be a member of the public or a scientist. The object will resemble a board game where the playing pieces relate to the coded information used by geneticists. The board will be 50x50cm, and can placed on a freestanding table for exhibition.
Year(s) Of Engagement Activity 2017
 
Description BBC1 television series "Holding back the years" 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Bill Turnbull, star of BBC's Breakfast News TV, Strictly Come Dancing, Classic FM etc., came to the Psychology department on 23rd January 2017 with a BBC film crew to find out about the Lothian Birth Cohort 1936 (LBC1936)/Disconnected Mind study.

BBC1 are planning a series in the Spring called 'Holding back the years'. Each programme will feature a celebrity revisiting a place that means a lot to them, and the programmes will have a focus on the processes of human ageing. Mr Turnbull was at the University of Edinburgh in the 1970's (he shared a flat with Gordon Brown for a term!), and so his programme is based here. It was natural that, to find out more about ageing, and with an Edinburgh locus, he and the BBC filming team visited the LBC1936. A busy afternoon's filming was filled with his interviewing LBC1936 Director Ian Deary, speaking with about a dozen of the LBC1936 participants, and seeing and taking part in some cognitive testing. Look out for the series, especially the Edinburgh-based Bill Turnbull programme in a few months' time.
Year(s) Of Engagement Activity 2017
URL http://www.ccace.ed.ac.uk/node/340
 
Description BMJ picture of the week 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The 'Picture of the Week' in the BMJ (Vol 348, issue 7964) showed two brain tractography images from the Brain Research Imaging Centre and from the Clinical Research Imaging Centre, both part of Edinburgh Neuroscience at the University of Edinburgh. The larger picture is from the LBC cohort (Lothian Birth Cohort) courtesy of Dr. Mark Bastin.

The image has now been seen by a wide variety of people including public and collaborators/peers. It raises awareness of our brain and cognitive work among healthy older people, and helps people understand the advances which imaging science have made in illustrating age-related brain changes.
Year(s) Of Engagement Activity 2014
 
Description BRAINS workshop August 2014 - Wardlaw 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The workshop in August 2014 aimed to introduce the "Brain images of normal subjects" bank, which is being developed by imaging centres across Scotland. the aim is to collect data from across the lifecourse in order to create BRAINS atlases and support image analysis research and clinical reporting of brain images.

Widened interest in the BRAINS bank and informed peers and public about its existence and usefulness.
Year(s) Of Engagement Activity 2014
 
Description Bak - Bilingualism media coverage 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Two papers of Bak's published in November 2013 (Alladi et al, Neurology) and June 2014 (Bak et al, Annals of Neurology) produced great interest in the media with ca. 400 press reports across the world for each of them (including North & South America, most of Europe, Middle East, India and China), in popular (USA Today, Metro) as well as high reputation (Der Spiegel, Corriere della Sera) newspapers. This included full interviews (Observer, El Mundo) as well as radio and TV interviews (BBC, Canadian TV). The BBC article devoted to this work was the most tweeted one on the day of publication (2 June 2014). The interest persists with regular invitations for interviews. Together with Bilingualism Matters (BM) and The Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) I conducted a twitter session in July 2014 and applied for a joint event at the Edinburgh Science Festival in April 2015. The Principal has sent Bak a personal letter of acknowledgement and selected his work to feature in the Annual Review of the University.



When the communications office at the University of Edinburgh tried to estimate the number of media outlets which this story reached, it ran to the hundreds, covering many international television, radio and printed and web-based news outlets. Together with CCACE, Bak has applied to run a joint event at the Edinburgh International Science Festival in April 2015. 'Speaking Two Languages Benefits the Ageing Brain' YouTube video has been watched over 2,400 times http://youtu.be/emNrOSLJseo.
Year(s) Of Engagement Activity 2014
URL http://youtu.be/emNrOSLJseo
 
Description Bak - Cambridge Bilingualism network 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Thomas Bak was invited to give a talk on 'Bilingualism across the lifespan' at the Cambridge Bilingualism Network at Cambridge University in 2014. This talk covered research findings using data from the Lothian BIrth Cohort 1936.

This was an excellent opportunity to showcase Bak's work on bilingualism and ageing, using data from the Lothian Birth Cohort 1936 study.
Year(s) Of Engagement Activity 2014
 
Description Bak - dementia, aphasia and movement disorders 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Thomas Bak regularly presents talks to patient and carer groups, in the area of dementia, aphasia and movement disorders (often under the auspices of charities such as Alzheimer Society or Progressive Supranuclear Palsy PSP Association).

The positive feedback received from these events is exemplified by a message he got from one of the organisers: "Just a note to thank you so much for such a thoughtful and helpful presentation on Tuesday. We all benefited greatly from your extensive understanding of this challenging illness and your clear empathy with people & their carers who are coming to terms with the diagnosis and adjusting to life and all the uncertainty they face. It was so encouraging to hear of an approach which looked at what is preserved and not just at the decline in capacity".
Year(s) Of Engagement Activity 2014
 
Description Brain Box 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The CCACE Director and Knowledge Exchange Officer have been involved in the development of a 'Brain Box'. This is a portable workshop/festival resource to excite children and adults about the brain, how it works and the changes it goes through in a lifetime. It is a resource for guided workshops, festivals, exhibitions and events that would over time develop an online 'personality' tweeting about its day with photos, comments and quotes: see it on Twitter @brainboxone.

This project is still in the development phase and received £4956 from the MRC Regional Communications Fund. Workshops are being planned as part of the Edinburgh International Science Festival 14-18 April 2015.
Year(s) Of Engagement Activity 2014
 
Description Brain Training on Trial Fringe show 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gow developed and delivered an hour-long show, "Brain Training on Trial", as part of the Edinburgh Festival Fringe, under the banner of Edinburgh Beltane's Cabaret of Dangerous Ideas. The show was attended by around 60 people. The trailer on You Tube had 533 views and 5 likes.

The event itself sparked discussion and questions afterwards. Gow produced a "summing-up" video on 20th October 2014, which has had 68 views on You Tube. Gow also wrote a blog article on the subject of Brain Training on Trial on the Research the Headlines blog, which is followed by 88 people.
Year(s) Of Engagement Activity 2014
URL http://researchtheheadlines.org/2014/09/09/brain-training-on-trial/
 
Description British Academy debate 29th April 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Centre director, Ian Deary, presented the work of the Centre as part of a debate entitled The best years of our lives? on 29th April 2014. This was very well attended - around 300 people - and well publicised by the British Academy and beyond. The debate was chaired by well-known broadcaster Sally Magnusson (who recently wrote a book on dementia which had extended interviews with Ian Deary and John Starr), and also had contributions from Age UK's Professor James Goodwin, Alzheimers Scotland's Henry Simmons, and Professor Catharine Ward-Thompson.

The event was well publicised and recordings of the debate made available through social media and the British Academy website. There was a lively discussion after the debate.
Year(s) Of Engagement Activity 2014
 
Description CCACE - Training courses 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact In 2012, 2013 and 2014 CCACE ran a number of short taining courses. These included "introduction to R programming", "longitudinal modelling", and "systematic reviews and meta-analysis".

R programming course has run 7 times between 2012-2014 with over 200 attendees.

SR course - 2 sessions. Dec 2012 (n = 16), November 2013 (n = 18).

Longitudinal modelling - 1 session in November 2013 (n = 50).

We have increased the visibility of CCACE and the skills that we can offer to a wider academic audience.
Year(s) Of Engagement Activity 2012,2013,2014
URL http://www.ccace.ed.ac.uk/students-training/training
 
Description CCACE Social Media 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CCACE has a significant following on social media (912 on Facebook; 701 on Twitter). Over the past year, the most watched research video was A Slower DNA Clock Predicts Longer Life by Dr Riccardo Marioni (https://youtu.be/bmpv-LDuL7s), viewed 748 times.
Year(s) Of Engagement Activity 2014,2015
URL https://youtu.be/bmpv-LDuL7
 
Description CCACE YouTube channel ccacevideo 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Since 2011 CCACE has posted 29 videos about events, research and the Centre on its YouTube channel.

The CCACE video channel has 36 subscribers and its videos have been viewed 13,302 times (as of 7th November 2014).
Year(s) Of Engagement Activity 2011,2012,2013,2014
URL http://www.youtube.com/ccacevideo
 
Description CCACE eNewsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Centres' Knowledge Exhange Officer produces a quarterly CCACE Newsletter detailing news and updates of Centre acitivity.

The Summer 2014 newsletter was circulated to 447 recipients with 190 (43%) opening it and 83 (19%) clicking on several of its links. For the Winter 2013/14 newsletter these figures were 446, 209 (47%) and 89 (20%).

In November 2011 this is circulated to a distribution list of over 220. Statistics from the January 2011 edition showed that ~60% opened the newsletter, and ~40% clicked on several of its links.
Year(s) Of Engagement Activity 2010,2011,2012,2013,2014
 
Description CCACE media coverage 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 21 Mar 2014 - LBC1921/1936 feature in review of UK population studies by MRC
17 April 2014 - LBC reunion covered by STV News
Spring 2014 MRC Network- coverage of Ian Deary's workspace
12th May 2014 "Edinburgh and Aberdeen depression study given £4.7m funds" - BBC News,; STRADL
11 June 2014- 9pm 'Frontier's - BBC Radio 4, - Latest thinking about our brain power in old age (Lothian Birth Cohort)
2 Jul 2014 - BRIC picture of the week
17 Jul 2014 - Bilingualism: Thomas Bak's paper - multiple media coverage. Answered live questions Bilingualism Matters; "Learning second language 'slows brain ageing'', BBC News June 2nd; The Australian news June 2nd; YouTube video >3,000 views: http://youtu.be/emNrOSLJseo
11 Aug 2014 - Stuart Ritchie on Infinite Monkey Cage -
11 Aug 2014 - Stuart Ritchie - visual processing and age on Good Morning Scotland, BBC Radio Scotland. YouTube video http://youtu.be/vWkgP5sWCNA
9 Oct 2014 - UK Dementia Platform Press Release http://www.ed.ac.uk/news/2014/dementia-190614 YouTube Video: http://youtu.be/xyer_t-X3lQ
30 Oct 2014 Science Magazine Article http://t.co/LxkPicGrvi
6 Nov 2014 Height associated with increased risk of dementia. New study from Tom Russ http://t.co/73cNJzhk1U https://youtu.be/BojlhIJ_TI8
20 Nov 2014 Complex jobs protect memory - http://www.bbc.co.uk/news/health-30115497
3 Dec 2014 Genetic study of Memory (CHARGE Consortium) http://www.ed.ac.uk/news/2014/memory-261114
3 Dec 2014 Nice mention of recent @ccace results from @claudiahammond & @CathLoveday on @BBCRadio4's All in the Mind, at 24m 30: http://www.bbc.co.uk/programmes/b04svjbn
Dec 2014 DM results appearing in Age UK's Report of Trustees (p. 19): http://www.ageuk.org.uk/Documents/EN-GB/Corporate/age_uk_annual_report_2013_14.pdf?dtrk=true
15 Jan 2015 BBC Breakfast does a nice story on The Disconnected Mind / Lothian Birth Cohort as it begins Wave 4. http://t.co/rHpVx8SVQI
20 Jan 2015 £15m boost for Scotland's gene research | News | http://www.ed.ac.uk/news/2015/scottishgenomes-120115
30 Jan 2015 DNA Clock helps predict lifespan http://youtu.be/bmpv-LDuL7s?a http://www.ed.ac.uk/news/2015/dnaclock-300115
http://www.independent.co.uk/news/science/dna-clues-could-predict-when-people-will-die-10014400.html
3 Feb 2015 Scientists @CCACE have identified genes associated with people's cognitive function-how we process information http://www.ed.ac.uk/news/2015/genes-030215
YouTube Video: http://t.co/7KSyLzvD6o
11 Feb 2015 Smokers tend to have thinner brain cortex http://www.independent.co.uk/news/science/smokers-have-thinner-brain-cortex-and-could-have-impaired-thinking-10039128.html
Release: http://www.ed.ac.uk/schools-departments/clinical-sciences/edinburgh-imaging/news/smokers-cortex
1 Dec 2015 Does Being Bilingual Protect Your Brain? - Thomas Bak on All in the Mind, BBC Radio 4 http://www.bbc.co.uk/programmes/p039w8gf?ns_mchannel=social&ns_campaign=bbc_radio_4&ns_source=facebook&ns_linkname=radio_and_music
22 Dec 2016 - Advances in the Genetic Basis of Intelligence: articles in The Guardian and The Telegraph. Jan 2016 - STV News LBC participant Mr Scott and Dr Simon Cox interviewed about new National Museum of Scotland Exhibit. STV News (from 15:30) at http://player.stv.tv/episode/36pt/news-at-six-edinburgh-east-full/thu-07-jan-6-00-pm/
Jan 2016 - Health and Thinking Skills Linked to the Same Genes -
Year(s) Of Engagement Activity 2014,2015,2016
 
Description CCACE on Facebook: CCACEedinburgh 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CCACE launched its Facebook page in 2011 featuring photographs, video and news about CCACE

147 people have "liked" the page so far, and actively share CCACE's newsfeeds.
Year(s) Of Engagement Activity 2011,2012,2013,2014
URL https://www.facebook.com/CCACEEdinburgh
 
Description CCACE public engagegement activities 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Jan 28th 2014 - Presented Disconnected Mind and CCACE 3D brain at Age UK's reception at St James's Palace hosted by HRH Prince Charles,
April 2014- LBC reunion To see coverage on STV visit http://news.stv.tv/east-central/272014-oaps-sit-same-test-for-eight-deca...
April 29th 2014 - Big debate -- the best years of our lives? - British Academy
May 16th 2014 - Gathering Intelligence: the life and work of Prof Sir Godfrey Thomson,
28 Oct 2014 Ian Deary presented at the launch of the Dementia Platform UK on 28 October 2015 at the Royal Society London
6 Nov 2014 - Lifelong Health and Wellbeing London - Zoe Tieges talks about development of DELBOX for diagnosis of delirium; Natalie Royle describes standardised ways of measuring older brains using brain imaging; Maria Valdez del Hernandez speaks about brain imaging stuff
19 Nov 2014 Ian Deary addressed the Age Scotland conference
20 Nov 2014 The Day Scotland Tested the Nations IQ part of Previously...Scotland's History Festival https://iqpreviously.eventbrite.co.uk
27 Nov 2014 Ian Deary gave keynote talk at Voluntary Health Scotland conference "Health, Wellbeing and Your Brain"
28th October 2014 - UK Dementia Platform launch, London,
14 Mar 2015 The Living Brain event at Cambo House Fife, 20 adults attended 3 hour session (talk from Ian Deary, interactive session with ID, RM and Helen Staton, showing of the Living Brain Film and open questions.
19 March 2015 Schools workshop at Davidsons Mains Primary School - 40 Children
9 April 2015 The Living Brain - Interactive panel discussion. Edinburgh International Science Festival - 80 Adult attendees.
14-18 April 2015 BrainBox Workshop - Edinburgh International Science Festival, National Museum of Scotland - 70 Children aged 8-12.
27 Aug 2015 Cabaret of Dangerous Ideas, Edinburgh Festival Fringe - Alan Gow presented "The Great British Brain Off" to 80 members of the general public.
October 2015 - Age: What is your number? Midlothian Science Festival evening event, 30 adult attendees.
November 2015 BrainBox Workshop - 20 Beaver Scouts.
Year(s) Of Engagement Activity 2014,2015
 
Description CCACE quarterly newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact CCACE has produced a quarterly newsletter since 2008. The newsletter mailing list has a varied audience of lay and scientists. It summarises major achievements of the Centre and our recent news items.
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012
URL http://www.ccace.ed.ac.uk/news-events/latest
 
Description Cabaret of Dangerous Ideas - Bak 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Edinburgh Fringe Festival, event attended by ca. 80 people (the second highest attendance in the series); after the show approached to write a blog for British Medical Journal, which later got published as a paper, and give an interview to the Fringe Radio.
Year(s) Of Engagement Activity 2016
URL http://codi.beltanenetwork.org/event/codi-2016-language-lessons-on-the-nhs/thomas-bak/
 
Description Cafe Scientifique cockermouth - Pickersgill 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Martyn Pickersgill: 'Enhancing What? Enhancing Who? Enhancing Why? Social Aspects of the Human Enhancement Debate', Café Scientifique, Cockermouth, 19th November 2013 (speaker).

Interest and enthusiasm shown by attendees.
Year(s) Of Engagement Activity 2013
 
Description Cambo Winter Talks Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Professor Deary gave a talk on normal cognitive ageing followed by lively discussion at this small science festival. It was a accompanied by activities related to cognitive ageing that were conducted by him and other members of the CCACE Centre.
Year(s) Of Engagement Activity 2015
 
Description Centre for Dementia Prevention annual winter conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Title: Centre for Dementia Prevention annual winter conference: "Preventing Dementia: Advice and Advances"
Type: Public lecture
Audience: General public, predominantly local
November 2017
Description: Public lecture, 250 attended
Impact: Improved understanding about recent advances in dementia prevention
URLs: http://centrefordementiaprevention.com/2017/11/30/1753/
https://media.ed.ac.uk/search/searchkeyword/centre%20for%20dementia%20prevention
Year(s) Of Engagement Activity 2017
URL http://centrefordementiaprevention.com/2017/11/30/1753/
 
Description Cognition and a Mediterranean diet research paper - Luciano 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact There was considerable media interest in a paper examining the link between consuming a Mediterranean diet and brain shrinkage. CCACE member, Michelle Luciano, gave Live TV interview on BBC Breakfast, pre-recorded TV interview for a South Korean News Channel, 2 Live radio Broadcasts (BBC Reporting Scotland, BBC 3 Counties), and 1 pre-recorded radio broadcast (Radio Forth)

Various interviews were also given for print media:
5/01/17: (BBC online ) (i) (The Press and Journal) (The Belfast Telegraph) (The Daily Express) (The Sun) (Metro) (New Scientist online) (The Herald) (The LA Times online (USA)) (The Times) (The Independent) (The Daily Mail) (Huffington Post online) (NBC News online) (The Irish Examiner online (Ireland)) (The Edinburgh Evening News) (The Evening Express) (La Vanguardia (Spain)) (Indo-Asian New Service (India)) (U.S. Food Stafety (USA)) (herenciageneticayenfermedad blog (Argentina)) (Health News Review (USA)) (ForeignAffairs.co.nz (New Zealand)) (Yahoo! India) (Channel 3000 (USA)) (Proceso Digital (Honduras)) (Nutraceutical World (USA)) (Top Sante (France)) (Yahoo! Actualites (France)) (The Business Standard (India)) (MedIndia (India)) (Visao Online (Portugal)) (Slashdot (USA)) (WOAI (USA)) (The New York Times (USA)) (Radio-Canada (Canada)) (Carriere Adriatico (Italy)) (Expatica (Netherlands)) (Inc.com (USA)) (WWLP (USA)) (TVA Nouvelles (Canada)) (ladepeche.fr (France)) (China News Service (China)) (The New York Times online (USA)) (Adnkronos (Italy)) (CNN (USA)) (NBC News (USA)) (U.S. News & World Report (USA)) (EFE - International Service (Spain)) (The Irish Daily Mail (Ireland)) (MedIndia (India)) (Point (France)) (AGF (Netherlands)) (Gosalute (Italy)) (Panorama (Italy)) (The New Zealand Herald) (Health Daily Digest (India)) (International Business Times (USA)) (Newser (USA)) (El Semanario Limitless (Mexico)) (Tech Times (USA)) (Day (Argentina)) (NutraIngredients.com (France)) (Sunday World (Ireland)) (La Sicillia (Italy)) (Monthly Prescribing References (USA)) (ProHealth.com (USA)) (Courrier Picard (France)) (Digital Journal (USA)) (EMaxHealth (USA)) (Sarasota Herald-Tribune (USA))
Year(s) Of Engagement Activity 2016
 
Description Cognitive epidemiology interview - Geoff Der 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CCACE member Geoff Der has given an interesting and wide-ranging interview about his work on intelligence, which you can hear through the link below. It includes a discussion on childhood intelligence, longevity and health, effects of maternal smoking and breast feeding on children's intelligence, and sex differences in intelligence.

Geoff told us, "This interview came about because a controversial blog post had claimed that intelligence was primarily inherited from one's mother and cited some of our work as important evidence of this. The blog gained a lot of publicity in the USA via social media and we were invited by the smartdrugsmarts website to give an interview on the research cited. However, before the interview could be arranged, a convincing rejoinder to the original blog had been published by the Forbes website. The smartdrugsmart website was still keen to go ahead with the interview as a more general piece about our research using the National Longitudinal Study of Youth. This is the result."
Year(s) Of Engagement Activity 2017
URL http://smartdrugsmarts.com/episode-158-intelligence-genetics/?utm_source=twitter&utm_campaign=post&u...
 
Description Cohort and Longitudinal Studies Enhancement Resources conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact This was an invited lecture in the evening following the Cohort and Longitudinal Studies Enhancement Resources' conference. It was at the British Library, it was ticketed at £8, and was sold out with a large waiting list. The lecture covered Professor Deary's team's work on healthy cognitive ageing using the follow-up studies of the Scottish Mental Surveys. The full lecture is available online at the CLOSER website. This was a good opportunity to spread the word on the research to a mixed group[p of longitudinal cohort researchers, lay public, and charity sector workers.
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=0rxgundtPTI
 
Description Cox & Davies - U3A East Lothian 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Talk given by Simon Cox and Gail Davies to the University of the 3rd Age Haddington Science Group, East Lothian, UK. Title: Brain, genes and cognitive ageing in the Lothian Birth Cohort studies. May 2015.
Year(s) Of Engagement Activity 2015
 
Description Cox - Cafe Scientifique, Cockermouth 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dr. Simon Cox gave a talk to the Café Scientifique in Cockermouth entitled: 'Postcards from your brain; we wish we were there. On the (mis)uses of brain imaging'. Illustrations of brain imaging were distributed to attendees in postcard form, and examples from the Disconnected Mind study among others were discussed as instances of appropriate MRI data usage. Now developed, Simon will also give this talk at future knowledge exchange events.

The talk was very successful with a great deal of interest and enthusiasm shown by attendees. Dr Cox hopes that this will lead to further invitations to similar events.
Year(s) Of Engagement Activity 2014
 
Description Cox - Colinton Literary Society, Feb 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Simon Cox presented a talk entitled New Adventures in Cognitive Ageing Research: The Lothian Birth Cohorts of 1921 & 1936 at The Colinton Literary Society, Edinburgh, UK. February. (c.50 attendees).

The event was successful in disseminating information on the work of the Centre and Lothian Birth Cohort studies to members of the public.
Year(s) Of Engagement Activity 2014
 
Description Cox - DRCMR, Copenhagen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Talk (Design, challenges and pitfalls in life span studies) on a week-long course for PhD students at the Danish Research Centre for Magnetic Resonance, University of Copenhagen. Attended by ~40 students and staff.
Year(s) Of Engagement Activity 2016
URL http://www.drcmr.dk/events/event/166
 
Description Cox - Seniors USP launch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Cox SR (2014) Work Package 3: The Lothian Birth Cohort 1936. Seniors USP Dissemination Group Launch Day, Glasgow, UK. May. (c.15 attendees).

This was an opportunity to share knowledge and plans for the MRC-funded Seniors USP study. It was attended by CCACE's collaborators and increased the opportunities for future collaborations and research.
Year(s) Of Engagement Activity 2014
 
Description Deary - AGE UK interview on Disconnected Mind / LBC1936 April 2014 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/parliamentarians
Results and Impact This interview was a wide ranging description of the rationale for and achievements of the Disconnected Mind / Lothian Birth Cohort 1936 project for internal Age UK purposes. The aim was to inform a wide range of individuals within Age UK about the achievements of this cognitive ageing (and broader ageing) study in order that professionals within the Age UK charity organisation could be well informed when dealing with policy professionals external to the organisation and older people more generally.

Age UK is the largest older age-related charity in the UK. They provide evidence to the UK government and more broadly, for example to the G7 conference. One example of the reach of the Disconnected Mind project is that the Age UK CEO, Tom Wright, delivered a talk to the G7 conference in November 2014 in Tokyo, and used evidence from the Disconnected Mind project in his slides. Also, Age UK were influential in urging the current Conservative government to undertake a large dementia initiative which was announced at the G7/G8 conference and could be partly credited for the MRC's dementias platform UK initiative.
Year(s) Of Engagement Activity 2014
URL http://www.ageuk.org.uk/about-us/what-we-do/the-disconnected-mind/
 
Description Deary - British Academy Expert Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact With CCACE fellow-elect, Dr Stuart Ritchie, Ian Deary obtained funding for and organised this British Academy-funded workshop on processing speed and its importance for cognitive ageing in humans held in April 2014. Among the 13 attendees were international experts from the USA, Europe and the UK. Also, Professor James Goodwin for Age UK attended in order to achieve knowledge exchange and impact for the discussions.


All of the discussions were audio recorded and slides made available. There were several impacts. First, Ian Deary and Stuart Ritchie wrote a summary article for British Academy Review and this made available the questions and discussion on processing speed to other academics. Second, Professor James Thompson of University College London extensively reported several of the talks with their Powerpoint slides on his much-read psychology blog, which reaches academics and lay people. Third, Professor James Goodwin took the results and their impact back to Age UK with a view to discussing how these were relevant to Age UK's aims in helping older people.
Year(s) Of Engagement Activity 2014
 
Description Deary - Glasgow Centre for Population Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Invited seminar: Deary, I. J. (2014). Healthy cognitive ageing. Glasgow Centre for Population Health. Glasgow, UK, January. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary had drinks with the audience and had further discussion.

A video of the talk was placed on the GCPH website and has been viewed many times.
Year(s) Of Engagement Activity 2014
 
Description Deary - Healthy ageing LBC studies Inner Wheel Club Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Deary, I. J. (2014). Healthy ageing: clues from the Lothian Birth Cohorts of 1921 and 1936. The Inner Wheel Club of Edinburgh. Edinburgh, UK, February. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took soup and sandwiches with the audience and had further discussion.

After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued.
Year(s) Of Engagement Activity 2014
 
Description Deary - Healthy cognitive ageing, York University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Ian Deary was invited to give a seminar on Healthy cognitive ageing at the University of York, October 2014.

Interest and enthusiasm shown by attendees, and increased knowledge of the work of the Centre and LBC studies. The host, Dr Gary Lewis, after discussion with Professor Deary, has established plans for a new collaboration with the Lothian Birth Cohort studies.
Year(s) Of Engagement Activity 2014
 
Description Deary - Leith Probus Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited talk: Deary, I. J. (2013). The Lothian Birth Cohort 1936. Leith Probus Club. Edinburgh, UK, October. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took tea with the audience and had further discussion.

After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued.
Year(s) Of Engagement Activity 2014
 
Description Deary - MRC Network spring 2014 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The MRC's publication, Network, published an article on Centre Director Ian Deary's workspace, which showcased the work of the Centre in spring 2014.

As is typical with these sorts of magazine-type articles, it attracted a lot of comment and attention, and many people, as a result, asked Professor Deary and colleagues about the history of the Scottish Mental Surveys and the work of the Lothian Birth Cohorts.
Year(s) Of Engagement Activity 2014
 
Description Deary - Pilrig St Paul's Guild, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited talk: Deary, I. J. (2013). The Scottish Mental Surveys and healthy cognitive and brain ageing. Pilrig St Paul's Guild. Edinburgh, UK, November. Ian Deary gave a talk on the follow-up studies of the Scottish Mental Surveys, especially the Lothian Birth Cohort studies of 1921 and 1936. It was described how these contribute to what we know about protective and risk factors for healthy cognitive ageing. The topic of dementia was also discussed. There was a lengthy question session afterwards and Professor Deary took tea with the audience and had further discussion.

After this talk the organisers thought it was so important and successful that they passed on Professor Deary's details to other group organisers and subsequent invitations ensued.
Year(s) Of Engagement Activity 2014
 
Description Deary Talk to Scottish Government Data Linkage Framework 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/parliamentarians
Results and Impact Deary was invited to present results from the follow-up studies of the Scottish Mental Surveys as an exemplar of data linkage to the Scottish Government Data Linkage Framework.

The Scottish Mental Surveys as a resource formed an exemplar of data linkage, informing future government plans in data linkage services.
Year(s) Of Engagement Activity 2013
 
Description Della Sala - Treasure Island 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Sergio Della Sala was involved in advising on a schools engagement programme entitled "Treasure Island: Discussion Notes from a Neuroscience Perspective" during 2014.

Interest and enthusiasm shown by pupils attending events in the programme.
Year(s) Of Engagement Activity 2014
 
Description Della Sala - false memories, Terra Mexico 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sergio Della Sala commented on a study claiming that the mind creates false memories, Terra Mexico, 20th August 2014.

This commentary was available in the public domain
Year(s) Of Engagement Activity 2014
 
Description Della Sala - neurolinguistic programming, Wired.it 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sergio Della Sala featured in an article on Wired.it speaking about how neurolinguistic programming as a science does not exist, 4th February 2014.

This article was in the public domain.
Year(s) Of Engagement Activity 2014
 
Description Della Sala - tickling yourself, Sunday Times 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Sergio Della Sala featured in an article in The Sunday Times on 26th January 2014 on why it is not possible to tickle oneself.

This article was in the public domain.
Year(s) Of Engagement Activity 2014
 
Description Disconnected Mind newsletter - 2013+ 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact The Disconnected Mind project, which includes the Lothian Birth Cohort 1936 study and involves many of the Centre's members, produces a quarterly newsletter summarising study progress, impact and the latest research findings. This is distributed to approximately 126 funders and research collaborators across the UK.

The newsletter is sent to funders as well as research collaborators, and information on the study and its findings has been used by Age UK, the LBC1936 study's main funders, in their publications.
Year(s) Of Engagement Activity 2013,2014
 
Description Edinburgh Festival Fringe - Alan Gow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Edinburgh, UK, 18th August, 2017.
What Keeps You Sharp? Show at the Edinburgh Festival Fringe as part of Edinburgh Beltane's Cabaret of Dangerous Ideas, Edinburgh, UK, 15th & 19th August 2017.
Year(s) Of Engagement Activity 2017
 
Description Edinburgh International Science Festival - Jenni Burton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Invited to participate in 'Scientists have your data' at the Edinburgh International Science Festival, organised by the ADRC-Scotland, the Farr Institute and the Usher Institute University of Edinburgh. Public engagement event. Contribution to session as data scientist, discussing care home data linkage, Summerhall, 3/4/17. Project on care home data linkage voted by audience to have the most demonstrable public benefit.
Year(s) Of Engagement Activity 2017
 
Description Edinburgh International Science Festival 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact CCACE held an interactive stall in the Museum of Scotland as part of the family drop-in activities at the Edinburgh International Science Festival 15th-19th April 2014. This was visited by over 2000 people over the course of the week, including Age UK's Chief Executive, Tom Wright. The stall and activities showcased the work of the Centre, particularly the Lothian Birth Cohort studies.

Children and parents were able to engage with many displays and objects relating to brain function and brain ageing. As in previous years many hundreds of people engaged with the Centre's representatives and illustrations of its work.
Year(s) Of Engagement Activity 2014
 
Description Edinburgh Speakers Festival - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The new Edinburgh Speakers Festival 2016 took place from 9th-11th September and our own CCACE Director was invited to be part of this year's prestigious line-up. Speakers covered a large variety of topics including cognitive ageing, devolution, politics, history, literature, fashion, Islam, capitalism, cycling, RBS, the Lockerbie bombing, whisky and women's equality, but all with a focus on Scotland. Ian's talk was entitled "Understanding Healthy Cognitive Ageing: Scotland's Unique Contribution" and took place on Saturday 10th September.

This is what Ian said about the event:

"Well" said Disconnected Mind Director Ian Deary, "That's the first time I have been on the same bill as Ken Livingstone and Ruth Davisdson! What an ecclectic programme." Ian spoke on healthy cognitive ageing to an audience at the Edinburgh Speakers Festival. Of course, the LBC1936's results were highlighted, with a focus on the likely protective factors for cognitive ageing. "There was a middle-aged finalist from this year's Brain of Britain Radio 4 show in the audience", said Ian, "so that was a good basis from which to explain how crystallised ability ages pretty well." As usual,the photos of Mr Scott and his brain images went down well with the enthusiastic attendees.
Year(s) Of Engagement Activity 2016
URL http://www.ccace.ed.ac.uk/node/327
 
Description Evans - Brain Awareness Week schools workshop 2014 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact Workshop for primary school children entitled "Who is the boss? How your brain runs your body" as part of the British Neuroscience Association's Brain Awareness Week, March 2014.

The children appeared very interested and engaged.
Year(s) Of Engagement Activity 2014
 
Description Explorathon - Museum of Scotland 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Centre was represented at Explorathon, an event at the Museum of Scotland held in September 2014. There were presentations about the human brain with a host of interactive objects and displays so that people understood about the brain function and ageing.

Interest and enthusiasm shown by members of the public at the event, including many young people, and increased awareness of the work of the Centre.
Year(s) Of Engagement Activity 2014
 
Description Faculty of Public Health Annual Scottish Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was a plenary invited keynote to the faculty of Public Health's annual conference. Professor Deary's talk was on healthy cognitive ageing, and he immediately followed and was heard by the Health Minister of the Scottish Government and her staff, as well as about 200 plus practitioners in public health. Therefore, it was a good opportunity to convey the work practitioners considering the important public health challenges for the Nation.
Year(s) Of Engagement Activity 2015
 
Description Frontiers BBC Radio 4 - LBC June 2014 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Results from the Lothian Birth Cohort studies were discussed by Ian Deary on BBC Radio 4's Frontiers programme, looking at the latest thinking about our brain power in old age. Robert Logie also discussed cognitive ageing on the programme.

The Lothian Birth Cohort studies were discussed alongside Cambridge studies and a provocative idea that there might be much less cognitive ageing than these studies suggest. As a result, there was discussion in the media, which reached the Centre, about the LBC studies.
Year(s) Of Engagement Activity 2014
 
Description Gow - INAPIC workshop, University of Zurich 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Gow was invited to participate in a workshop entitled "Developmental Models of Brain-Behavior change relationships" held at the International Normal Aging and Plasticity Imaging Center, University of Zurich, on September 12-14 2013.

Expertise and research was shared amongst a group of eminent international speakers, including the INAPIC Advisory Board.
Year(s) Of Engagement Activity 2013
 
Description Gow - keynote Active Ageing conference Oct 2014 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Keynote presentation at Active Ageing conference, Hamilton, October 2014. This was attended by more than 150 professionals and brought together representatives from partner agencies and older adults alike.

The conference was reported through a variety of media channels, and many ideas and innovations were shared.
Year(s) Of Engagement Activity 2014
 
Description HMC conference - Stuart Ritchie 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact October 4 2016: gave a talk on intelligence generally, including LBC1936 data, to the HMC conference (audience: headteachers) in Stratford
Year(s) Of Engagement Activity 2016
 
Description HRH The Princes Royal 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact On the 6th July 2016 our University of Edinburgh Chancellor, HRH The Princess Royal, opened the new Centre for Dementia Prevention Building in the Bioquarter at Little France. The Centre for Dementia Prevention is led by Professor Craig Ritchie and aims to help society to understand what causes Dementia and then hopes to devise and implement strategies and lifestyle changes that will prevent Dementia from developing in the first place. CCACE was invited to this event as a complementary Centre working in ageing research at Edinburgh. Beverly Roberts represented CCACE at the opening in her role as Centre Scientific Administrator. After an initial tour of the new building, the Princes Royal was shown in to the reception marquee and introduced to a number of projects/Centres based at Edinburgh who work in both pathological and nonpathological ageing. When she was introduced to Beverly and CCACE, the Princes Royal showed great interest in the work of our members and asked why studying normal ageing was so important in the context of dementia. After the formal introductions there was an afternoon tea reception where Princess Anne was able to talk to some of the 120 invited guests. Beverly was very busy during this time speaking to lots of interested individuals wanting to know more about normal cognitive ageing.
Year(s) Of Engagement Activity 2016
URL http://www.ccace.ed.ac.uk/node/326
 
Description Healthy cognitive ageing - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Deary, I. J. (2016). Healthy cognitive ageing. Iain Whyte House Group. North Queensferry, UK, February.

Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages.
Year(s) Of Engagement Activity 2016
 
Description Healthy cognitive ageing - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Deary, I. J. (2016). Healthy cognitive ageing. University of the Third Age Science Group. Edinburgh UK, March.

Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages.
Year(s) Of Engagement Activity 2016
 
Description Healthy cognitive ageing and the Lothian Birth Cohorts of 1921 and 1936 - Ian Deary 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Deary, I. J. (2016). Healthy cognitive ageing and the Lothian Birth Cohorts of 1921 and 1936. The Senior Fellows Club of the Royal Colleges of Physicians and Surgeons of Edinburgh. Edinburgh, UK, May.

Overview of general information on individual differences in human cognitive and brain ageing. Most examples taken from work on the Lothian Birth Cohorts of 1921 and 1936 and other cognitive ageing studies headed by Ian Deary at the University of Edinburgh. Followed by an extended question time raising additional points and ensuring understanding of the key messages.
Year(s) Of Engagement Activity 2016
 
Description Hosting work experience pupils 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact CCACE hosted a series of work experience placements for pupils in s5/6 (secondary school). Pupils were given the opportunity to meet with CCACE members and observe some of the work of the Centre, including brain imaging, cognitive testing, and public engagement.

These placements were a great success, with several schools expressing an interest in sending pupils to the Centre for work experience in the future.
Year(s) Of Engagement Activity 2014
 
Description How to Have a Better Brain - Gow 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Our former LBC Team member Dr Alan Gow (now at Heriot-Watt University), still actively engaged in LBC research, featured in the first episode of the new Radio 4 series 'How to have a better brain', presented by Sian Williams. The series aims to deliver a practical guide to boosting brain functioning throughout life with topics including sleep, diet, relaxation and exercise. The first episode focusses on the effect of exercise on brain function and in his interview, Alan draws on research evidence from the LBC1936. The episode and the associated online-only segment are available on the BBC iPlayer (http://www.bbc.co.uk/programmes/b065ssr8; http://www.bbc.co.uk/programmes/p02zz7ql)
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b065ssr8
 
Description Leith Labs - Alan Gow 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The Ageing Lab - Can taking up new activities improve the health and wellbeing of older adults? Workshop at Stay Sharp in Older Age hosted by Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE) in association with Leith Labs (part of The MRC Festival of Medical Research), Edinburgh, UK, 17th June 2017.
Year(s) Of Engagement Activity 2017
 
Description Life as a geneticist - Harris 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact A morning session talking to primary school children about life as a geneticist. The children made DNA models out of sweets and cocktail sticks (February 2016).
Year(s) Of Engagement Activity 2016
 
Description Lifetimes event at Midlothian Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Discussion session about the history and current research relating to the Lothian Birth Cohorts, and a showing of the short film The Living Brainabout the Lothian Birth Cohorts. Followed by hands-on reaction time testing and demonstration of brain images/3D printouts.
~30 members of the public attended a talk and a Q and A session.

A great deal of interest in the Lothian Birth Cohort studies and multiple Q andA sessions with a very engaged audience.
Year(s) Of Engagement Activity 2014
URL http://midlothiansciencefestival.com/event/lifetimes/
 
Description Lothian Birth Cohort Study 1921 annual newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The Lothian Birth Cohort Study 1921 has produced an annual newsletter since 2003. It was written to inform cohort study members of any main results from the study. The newsletter mailing list has a varied audience of lay and scientists. It summarises major achievements of the Centre and our recent news items.
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,
 
Description Lothian Birth Cohort Study 1936 annual newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The Lothian Birth Cohort Study 1936 produces and annual newsletter which is sent to a large mailing list of over 500 individuals. Most of those on the mailing list are study members of the LBC cohort. The newsletter lets them know of new results which their data has produced. It is sent out with the study Christmas card.
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,
 
Description Lothian Birth Cohort reunion April 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience