MICA: Psoriasis Stratification to Optimise Relevant Therapy (PSORT)

Lead Research Organisation: University of Manchester
Department Name: School of Biological Sciences

Abstract

Psoriasis is a common, chronic, potentially disfiguring disease that affects more than 1 million people in the UK. It can cause considerable psychological and social disability. In the past 10 years there has been a dramatic improvement in clinical outcomes for patients with severe psoriasis due to the introduction of a new class of injectable drugs called biologics. These work by targeting specific parts of the immune system which are important in causing psoriasis. However, these drugs are very expensive (estimated annual cost is £10,000) and it remains the case that a significant number of patients fail to respond adequately. If we could predict which patients will do well with a particular biologic drug then we could devise new treatment plans that would be personalised for each patient rather than the current system of "trial and error" prescribing. This would be of added benefit to society as a whole since it could result in significant cost savings to the NHS and aid the pharmaceutical industry in development of new drugs.
The programme of research in the Psoriasis Stratification to Optimise Relevant Therapy (PSORT) consortium aims to use existing knowledge about psoriasis, both clinical and scientific, our unparalleled patient base coupled to involvement of patient organisations and state-of -the-art investigative tools to develop tests that we can use in the clinic to help direct personalised treatments. Specific questions we will ask are: i) do levels of a drug in the blood and a patient's immune response to that drug effect outcome; ii) are there specific changes in the skin and blood that predict which drug is likely to be more useful in a particular patient; iii) is there variation in a patient's genetic make-up, linked to psoriasis and how drugs work, that may predict response to treatment; and iv) does bringing all the information collected in i-iii above, though computer based data analysis, have more power to predict response to treatment?
Succssfully achieving such a goal requires a number of important criteria to be met. Perhaps most importantly we need consent from large numbers of patients to enter studies and provide samples of blood and skin. From the start of the study, we have engaged with the Psoriasis Association (patient organisation) to ensure the study met with their approval. As a consequence of patient engagement, in the UK we have arguably the world's leading safety registry for patients receiving biologic drugs for psoriasis. During the lifetime of our proposal, it will have accumulated comprehensive information on 7,000 patients including responses (good and bad) to biologics. The PSORT consortium includes representatives from 4 of the largest psoriasis clinics in the UK. These will provide the source for patient recruitment.
The experiments will take advantage of several factors. First, in contrast to many other chronic diseases, change in psoriasis severity is simple and accurate to determine after starting therapy. Second, target organ tissue (i.e. skin) can be sampled in a minimally invasive way by skin biopsy (patient feedback tells us that this is acceptable to them). Third, internationally competitive expertise exists across the consortium between investigators and collaborators in all of the scientific disciplines required to successfully deliver the programme. Fourth, appropriate research infrastructure exist at each of the three main centres namely Manchester, Newcastle and London. This includes the registry itself (Manchester) and NHS funded facilities (Newcastle and London). Finally, we have developed an extensive network of pharmaceutical company partners who bring specific expertise and resources to the programme. Not only will this help in achieving the short term goals but it will also provide the necessary platform for translating the outcomes into clinically useful tests.

Technical Summary

Biologic therapies for severe psoriasis are currently prescribed in a stochastic manner that is neither efficient nor cost-effective. The vision of the PSORT consortium is to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. To deliver this vision PSORT has brought together a powerful grouping of world-leading psoriasis researchers, bioinformaticians, statisticians, health economists and industry partners. Patient representation informs the consortium which utilises NIHR and MRC funded platforms and an established, high-quality clinical bioresource the British Association of Dermatologists' Biologic Interventions Registry (BADBIR) involving 143 UK dermatology centres (5500 patients by 2014). Two parallel, interlinked Work Strands will provide clinical, adherence, pharmacological, genetic, transcriptomic, and immune data in blood and skin on psoriasis patients treated with biologics. Deeply-phenotyped Discovery and Refinement cohorts sponsored by academia and industry are complemented by large scale validation in BADBIR and in a prospective clinical pilot study of minimal effective dosing of biologics. The data will be integrated and interrogated through TranSMART infrastructure enabling a combination of bioinformatics, machine learning and biostatistics for the discovery of drug response endotypes/biomarkers. Working with our partner diagnostics companies these will be scalable for clinical use. Operational management will be proactive and milestone driven with oversight provided by an Independent Advisory Board. It is anticipated that the PSORT consortium will be a major catalyst to deliver novel personalised medicine approaches in the management of psoriasis.

Planned Impact

The main beneficiaries of the Psoriasis Stratification to Optimise Relevant Therapy (PSORT) consortium will be people with psoriasis, who will have improved access to effective treatment. The majority of people who develop psoriasis are young - 75% develop the condition before 35 years of age. Thus, this predominantly lifelong condition can have a significant detriment on an individual's chances of achieving their full potential. For instance, loss of sleep and time away from school for healthcare visits and hospital admission, difficulty in forming relationships and exclusion from social and sporting activities because of the stigma of psoriasis and exclusion from public-facing employment. The wider patient impact is also important in that family members are frequently involved with the care of psoriasis patients. These all contribute to a significant burden from a disease that affects at least one million people in the UK. Optimised treatment results in improvements in quality of life, and also has the potential to impact on important associated co-morbidities such as depression, psychosocial and physical disability and cardiovascular disease.

The outputs from PSORT will allow more accurate matching of the treatment to the disease, facilitating more rapid and individualised transitioning onto the most effective and safest drug. Those who fail to respond to the initial treatment will be recognised more quickly allowing them to progress to more suitable treatment, with less exposure to ineffective treatment. Currently, patients whose disease is completely suppressed by biologic treatment continue this treatment indefinitely. PSORT will allow tailoring of drug dose to the minimum that is effective and in some, whose disease is in remission, treatment may be interrupted or stopped, reducing the risk of side-effects. It is likely that issues related to pharmacokinetics and drug immunogenicity and their association with the mechanisms of treatment failure will relate equally to patients with other immune mediated inflammatory diseases such as rheumatoid arthritis and Crohn's disease, allowing these impacts to benefit an even greater number of patients.

The pharmaceutical and biotechnology industries involved with the development of small molecules, biologics and biosimilars for psoriasis treatment will benefit from stratification, both in the identification of new therapeutic targets and in clinical trial design. These benefits will include: de-risking of drugs (for instance in dose optimisation); and using the PSORT classification of psoriasis to design adaptive trials to test new drugs in small, well-characterised cohorts of patients, including through the NIHR Translational Research Partnerships. Diagnostic companies will be able to use potential psoriasis stratifiers to develop and commercialise companion diagnostics.

Professional bodies (e.g. British Association of Dermatologists) and National Institutions (e.g. NICE and Scottish Intercollegiate Guidelines Network) responsible for the development of clinical practice guidelines will benefit from stratification of psoriasis in that patient pathways and guidance for starting and /or switching biologics will gain a substantial evidence base. In terms of education of clinical professionals, classification of psoriasis will inform future teaching and learning.

The NHS and other healthcare providers and their funders will benefit from an effective and efficient use of expensive drugs by an approach that targets those patients who are at highest likelihood of responding, informing evidence-based policy making. Dose minimisation strategies and drug discontinuation in patients who have achieved remission has the potential to make significant cost savings whilst maintaining patient benefit. Early, targeted disease altering management will benefit not only the health of individual patients but would significantly increase their contribution to society.

Publications

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Dand N (2018) HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. in The Journal of allergy and clinical immunology

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Foulkes AC (2017) Research Techniques Made Simple: Bioinformatics for Genome-Scale Biology. in The Journal of investigative dermatology

 
Description British Association of Dermatologists (BAD) conference travel bursary of £250 to R Andres-Ejarque (Kings College London) to attend BSID meeting, competitive process
Amount £250 (GBP)
Organisation British Association of Dermatologists (BAD) 
Sector Learned Society
Country United Kingdom
Start 03/2018 
End 03/2018
 
Description Capital Investment in Human Tissue Biobanking and Linkes Data in partnership with Charities (IMID-Bio UK)
Amount £1,707,539 (GBP)
Funding ID MR/R014191/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 03/2021
 
Description European Society for Dermatological Research (ESDR) travel grant awarded to N Dand (Kings College London) to attend ESDR meeting 2016, competitive process
Amount € 500 (EUR)
Organisation European Society of Dermatological Research (ESDR) 
Sector Learned Society
Country European Union (EU)
Start 09/2016 
End 09/2016
 
Description European Society for Dermatological Research (ESDR) travel grant awarded to N Dand (Kings College London) to attend ESDR meeting 2017, competitive process
Amount € 1,000 (EUR)
Organisation European Society for Dermatological Research 
Start 09/2017 
End 09/2017
 
Description European Society for Dermatological Research (ESDR) travel grants of 1,500 each awarded to R Andres-Ejarque; T Tsakok & N Dand (Kings College) to attend IID conference, competitive process
Amount € 4,500 (EUR)
Organisation European Society of Dermatological Research (ESDR) 
Sector Learned Society
Country European Union (EU)
Start 05/2018 
End 05/2018
 
Description Genetics Society Juniour Scientist travel grant awarded to N Dand (Kings College London) to attend 2017 GRC Quantitative genetics meeting
Amount £750 (GBP)
Organisation The Genetics Society 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 03/2017
 
Description MRC Stratified Medicine Consortium Awards
Amount £4,900,000 (GBP)
Funding ID MR/L011808/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2014 
End 08/2018
 
Description Psoriasis: From Gene to Clinic Congress Education Grant awarded to N Dand (Kings College London) for registration for Psorisis: from gene to clinic meeting
Amount £300 (GBP)
Organisation National Center for Biotechnology Information (NCBI) 
Sector Public
Country United States
Start 11/2017 
End 12/2017
 
Description PSORT 
Organisation AbbVie Inc
Country Global 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Becton, Dickinson and Company
Country United States 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation British Association of Dermatologists (BAD)
Country United Kingdom 
Sector Learned Society 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Celgene
Country United States 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation GlaxoSmithKline (GSK)
Department Steifel
Country United States 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Guy's and St Thomas' NHS Foundation Trust
Department Dermatology
Country United Kingdom 
Sector Hospitals 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Johnson & Johnson
Department Janssen-Cilag
Country Global 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation MedImmune
Country United States 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation NHS Greater Glasgow and Clyde (NHSGGC)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Newcastle University
Department Dermatological Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Pfizer Ltd
Country United Kingdom 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Qiagen
Country Netherlands 
Sector Private 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Royal College of Physicians of London
Country United Kingdom 
Sector Academic/University 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Royal College of Physicians of London
Country United Kingdom 
Sector Academic/University 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation Sanquin
Country Netherlands 
Sector Charity/Non Profit 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation The Psoriasis Association
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Description PSORT 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution The team have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings.
Collaborator Contribution The partners have worked to to build a consortium to secure MRC and industry funding to develop a stratified medicine approach for psoriasis to better understand determinants of response to biologic therapies and deliver, in close collaboration with commercial partners, a PSORT stratifier (algorithm) to guide psoriasis management. This will optimise clinical pathways for psoriasis, inform the management of other less accessible immune-mediated inflammatory diseases and deliver health care savings. Partners are contributing clinical, biostatistical, bioinformatics,skin biology, nursing, clinical dermatology, machine learning, health economics, pharmacy, genetics, systems biology and management and governance expertise. As well as equipment, software, clinical trial samples, somalogic testing, RNA extraction and sequencing, methodological know-how, clinical trial datasets, data management and pharmacovigilance data. Industry partners are contributing in excess of £2.5million of combined monetary and in-kind contributions.
Impact Received funding award of £4.9 million from the MRC Stratified Medicine Consortium programme and a further contribution of >.£2.5 million investment (both in-kind and monetary) from industry partners PSORT is a mutli-disciplinary consortium involving: clinical dermatology skin biology nursing bioinformatics biostatistics machine learning health economics pharmacy genetics systems biology management and governance
Start Year 2014
 
Title Psoriasis Shout Out 
Description The Psoriasis Shout Out is a unique patient and public engagement initiative founded at Manchester University. The brand and name is registered for protection so it can be licensed for use when the initiative was expanded and rolled out to the universities of King's College London, Newcastle and Dublin. 
IP Reference  
Protection Trade Mark
Year Protection Granted 2015
Licensed Yes
Impact The Psoriasis Shout Out now has an international reputation and has been transformational for patients by educating them on the latest medical treatments for the disease, methods and techniques for self management and understanding that there is hope - patients can live well with the disease with the right professional health care and with self-management.
 
Description A national public engagement event 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The Psoriasis ShoutOut 2016 extended the original 2014 Manchester Psoriasis Shoutout to involved partners from several sites around the country, the Republic of Ireland as well as others in the US and Singapore.
Year(s) Of Engagement Activity 2014,2016
URL http://www.psoriasisshoutout.co.uk/
 
Description How Precision Medicine will transform Healthcare 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Audience: Staff and students engaged in or supporting all P4 medicine research affiliated with the BRC, The University of Manchester and/or Health Innovation Manchester.

This event was designed to provide all staff and students with the opportunity to update their knowledge and skills on P4 Medicine (Predictive, Preventive, Personalised and Participatory)

This event, in partnership with Manchester Precision Medicine Institute (MPMI) and Health Innovation Manchester, aimed to provide attendees with an understanding of implementation of precision medicine approaches and an overview of some of the existing research in this area across Manchester including PSORT and within industry.
Year(s) Of Engagement Activity 2018
 
Description PSORT Research Users Groups 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Meetings of patients / research users have been held at three PSORT centres. the meetings are to keep patients informed and to seek advice from patients regarding the ongoing development of the research programme.
Year(s) Of Engagement Activity 2014,2015
 
Description Psoriasis Association AGM 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact The Association is a partners in PSORT helping to inform the clinical studies based on questionnaires regarding treatment completed by patients / members of the Association, The talk was to inform patients and members on the progress of PSORT, to update on next steps and to thank the Association for its continued support.

The talk was well received, generating questions and discussion,
Year(s) Of Engagement Activity 2016,2017
 
Description St Johns Institute of Dermatology, Guys hospital: psoriasis and eczema PPI event (summer) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact The Association is a partner in PSORT helping to inform the clinical studies based on questionnaires regarding treatment completed by patients / members of the Association. The talk was to inform patients and members on the progress of PSORT, to update on next steps and to thank the Association for its continued support. The talk was well received, generating questions and discussion.The most significant outcome/impact was the requests about (further) participation or involvement; patients better understood what we could, and what we were trying to achieve with their participation.
Year(s) Of Engagement Activity 2017
 
Description St Johns Institute of Dermatology, Guys hospital: psoriasis and eczema PPI event (winter) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Members of the PSORT team and others gave talks about some of the latest findings in dermatology research, our current portfolio of studies and provided a forum in which patients could ask questions about the current work. Researchers were also able to ask patients some questions about what kind of research activities they would participate in, e.g. no. of biopsies. The most significant impact of this activity was the requests about (further) participation or involvement; patients better understood what we could and what we were trying to achieve with their participation.
Year(s) Of Engagement Activity 2017