Centre for Ageing and Vitality

Lead Research Organisation: Newcastle University
Department Name: Institute of Neuroscience

Abstract

Promoting lifelong health is important because age is the greatest risk factor for a wide range of clinical diseases, from cancer to cardiovascular disease. This is particularly important because there are an increasing number of elderly people in Western societies, and these individuals often have multiple health problems. Therefore preventing age related disease is a priority. Ageing results from a gradual, lifelong accumulation of damage to our bodies. Crucially, we know that many of the mechanisms involved in the ageing process can be modified by lifestyle factors such as physical activity and nutrition.

The LLHW Centre for Ageing and Vitality aims to link together studies which look at the way we age with studies exploring the effectiveness of lifestyle factors. We believe these studies will lead to new insights into how these interventions work and new ways to allow healthy ageing in the future. Our major research programmes looking at the way we age will focus on abnormalities that occur in the way we produce energy through mitochondria and on the way our bodies react to damaged tissues (called inflammation). The major lifestyle programmes are based on looking at the effect of physical activity, or the reduced level of physical activity, as we age. We will also look at how what we eat can change the ageing process, for example, why do overweight individuals develop more age related disease?

To ensure we make as much progress as possible, the Centre will have five core activities that will be crucial for all of the different programmes of research.
These core activities are:
1. Developing models of ageing in mice so we can carefully study the effects of lifestyle interventions such as exercise and nutrition on different organs;
2. Collect and carefully store tissues from human subjects and mouse models to ensure that we can use these optimally for research;
3. Understand how the effects of physical activity and nutrition alter ageing tissues;
4. Deliver the best possible training to young scientists so that they will become future research leaders in lifelong health and wellbeing;
5. Provide valuable information to the public about lifelong health in a way that they will find it helpful and informative. Influence decisions made locally, regionally and nationally to help improve lifelong health

Technical Summary

Our plans focus on scientific themes which reflect the overall mission of the Centre to increase our understanding of the biology of the ageing process, and how physical activity/exercise and nutritional interventions influence these mechanisms. Our studies will bring together four different programmes of LLHW research. Our major mechanistic research programmes focus on mitochondrial and inflammatory ageing mechanisms which will combine well with our on-going interventions programmes in physical activity/exercise and nutrition. To ensure the cross-disciplinary nature of the LLHW Centre, five core activities have been identified which are specifically designed to facilitate extensive interaction between the four scientific programmes of investigation.
Core activity 1: Interventions in animal models: development, optimisation and use of exercise/physical activity and nutrition interventions in appropriate mouse models
Core activity 2: Human and mouse tissue resource: collection, storage and processing of human and animal tissues from the intervention studies for use in mechanistic investigations
Core activity 3: Epigenetics and transcriptomics: we hypothesise that many of the consequences of both mitochondrial and inflammatory ageing, and their modulation by specific lifestyle interventions, will be mediated by epigenetic mechanisms and associated changes in patterns of gene expression.
Core activity 4: Capacity building for future LLHW research: key staff appointments and capacity building PhD and post-doctoral training programmes which will be strictly cross-disciplinary in design, involving both the intervention studies and mechanistic investigations.
Core activity 5: Public and policy engagement: ensuring impact for our research is dependent not only upon high quality publications but also increasingly on engaging with public and policy makers. This will be a core activity to ensure that this is given a high priority within our Centre

Planned Impact

The main impact of this research is to deliver on the strategic aims of the Research Councils, "living a long and healthy life". The whole focus of the research is to support bioscience research to help sustain lifelong health and wellbeing and to use our scientific discoveries to develop lifestyle interventions tailored for individual needs. We will do this by developing a better understanding of the role of diet and physical activity and the mechanisms by which they affect health.
Who will benefit from this research?
1. Public and patients with age related diseases. Our research will lead to better insights into the role in ageing of lifestyle factors, such as diet and physical activity. This will have an impact on public health (through our links with UKCRC Centre for Translational Research in Public Health (FUSE)) and patients with age related disease (through links with Newcastle NIHR BRC for Ageing and Age related diseases).

2. Policy makers. Our research will provide the scientific evidence upon which policy makers deciding on both public health issues and research priorities in the future will be able to make informed decisions.

3. Academic beneficiaries. The major academic beneficiaries will be the PhD students and junior research associates we train and the scientists in associated research centres with whom we will interact (MRC/ARUK Centre for Integrated Musculoskeletal Ageing (CIMA), the MRC Translational Centre for Neuromuscular Diseases, the UKCRC Centre for Translational Research in Public Health (FUSE), RCUK funded Social Inclusion through the Digital Economy hub, Newcastle NIHR BRC for Ageing and Age related diseases, and Wellcome Trust Centre for Mitochondrial Research

4. Industrial partners. Our current (Novartis, GSK, IMEC, Microsoft and Alere) and future industrial partners will benefit from our scientific advances and continued collaboration around the scientific understanding of lifestyle interventions.

How will they benefit from this research?
1. Public and patients with age related diseases. The primary aim of the LLHW Centre for Ageing and Vitality is to develop individualised lifestyle interventions suitable for the public and for patients with age related diseases. These will be translated through our links with UKCRC Centre for Translational Research in Public Health (FUSE) and Newcastle NIHR Biomedical Research Centre for Ageing and Age related diseases

2. Policy makers. The Centre for Ageing and Vitality will influence policy through the Newcastle Initiative on Changing Age. This initiative, led by Tom Kirkwood, will influence policy both locally and regionally through the Newcastle and North East Charters on Changing Age. The policy makers will also benefit from specific expertise within the Centre on key public health issues: John Mathers (nutrition through the life course) and Mike Trenell (physical activity through the life course).

3. Academic Beneficiaries. All junior scientists in the Centre will be part of the LLHW-Newcastle University training school which will include research retreats, specific invited speakers, training in generic skills, engagement opportunities, interaction with industrial partners and policy internships. Associated Research Centres will benefit by joint seminars, research training opportunities, scientific advances that they will be able to translate in patients and use of joint scientific techniques

4. Industrial partners. Our industrial partners will benefit from our identification of ageing mechanisms which could lead to targets which would be influenced by specific drug therapies. Our expertise in molecular mechanisms also helps in developing screens for compounds with a possible effect on ageing mechanisms. Our studies to develop and validate improved sensors for physical activity and physiological monitoring and better analysis of physical activity data will help companies provide individualised physical activity regimes.

Publications

10 25 50

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Ahmed ST (2018) Diagnosis and Treatment of Mitochondrial Myopathies. in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

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Alston CL (2017) The genetics and pathology of mitochondrial disease. in The Journal of pathology

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Anderson R (2018) Mechanisms driving the ageing heart. in Experimental gerontology

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Avery L (2017) Lifestyle Behavior Change in Patients With Nonalcoholic Fatty Liver Disease: A Qualitative Study of Clinical Practice. in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

 
Description Co-chair of Workshop - ESRC/BBSRC Epigenetics Showcase. London. May 2019
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
URL https://bbsrc.ukri.org/news/events/2019/1905-epigenetics-showcase/
 
Description EFSA Conference 2018, Science, Food & Society; 'The future of research in personalised nutrition'
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
URL https://conference.efsa.europa.eu/
 
Description Gave evidence to House of Lords on Mitochondrial Donation
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Led to change in UK law to permit the mitochondrial donation technique to be offered to women suffering from mitochondrial disease to prevent transmission of the disease to their children.
 
Description House of Lords Science & Technology Committee Inquiry into Ageing: markers, prediction and diagnosis. London. November 2019
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://www.parliament.uk/lords/
 
Description IDF mHealth and diabets global expert working group
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
URL http://www.gsma.com/connectedliving/idf-mou/
 
Description International Commission on the clinical use of Human Germline Genome Editing
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact The commission's aim is to develop principles, criteria and standards for the clinical use of genome editing of the human germline, should it be considered to be acceptable by society.
URL https://royalsociety.org/topics-policy/projects/genetic-technologies/international-commission/
 
Description JCM Chair Cross- Council Food Nutrition and Health Steering Group
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description JCM Food Nutrition and Health initiative
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description MRC Nutrition and Health Review Workshop, 7th - 8th July 2016
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MRC Review of Nutrition and Human Health Research, 14 Oct 2016
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description MRC Review of Nutrition and Human Health research - 17th March
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description NICE Liver Disease Guidelines
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://www.nice.org.uk/guidance/indevelopment/gid-cgwave0692
 
Description NU-AGE undergraduate module
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact As a result of participating in this module, undergraduates from faculties other than the Medical Sciences Faculty have chosen undergraduate degree projects to pursue a PhD in ageing research, The NU-AGE teaching module was shortlisted for a CATE by the Higher Education Academy.
URL http://www.ncl.ac.uk/module-catalogue/module.php?code=AGE2000
 
Description Our Centre Director met with Senators and representatives of the Australian Minister of Health in Canberra to discuss the recent changes to the law in the UK which allows mitochondrial donation to prevent transmission of mitochondrial disease.
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
 
Description Postnote for Parliamentarians on 'Healthy Ageing'
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Presentations to MPs and Peers at Houses of Parliament
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact Houses of Parliament voted to change the law to allow novel IVF techniques to prevent the transmission of mitochondrial disease. HFEA Licensing agreements are not yet confirmed, but once these are in place the technique could potentially benefit 152 women in the UK a year who are at risk of transmitting the disease. 2017 Update: HFEA licensed the treatment for use in the UK in March 2016. Further approval has to be granted by the HFEA for individual treatments.
 
Description Accelerator Grant: Hepatocellular Carcinoma Expediter Network HUNTER
Amount £3,256,773 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2023
 
Description Alzheimer's Research Grant
Amount £255,971 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 08/2020
 
Description BMedSci - Intercalated degree Bursary for Amy McWhirter
Amount £5,000 (GBP)
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 08/2018
 
Description BRC single cells using imaging mass spectrometry
Amount £135,711 (GBP)
Organisation Royal Brompton & Harefield NHS Foundation Trust 
Department NIHR Biomedical Research Unit
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2021
 
Description CASE Studentshop
Amount £122,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 08/2019
 
Description CASE studentship
Amount £122,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 08/2019
 
Description CRUK Research Bursary
Amount £25,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2015 
End 02/2016
 
Description Can we protect neurons against mitochondrial dysfunction?
Amount £163,787 (GBP)
Funding ID F-1401 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2017 
End 07/2019
 
Description Can we protect neurons against mitochondrial dysfunction?
Amount £413,745 (GBP)
Funding ID F-1401 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 06/2020
 
Description Clinical Trial
Amount £214,235 (GBP)
Organisation Food and Drug Administration (FDA) 
Sector Public
Country United States
Start 01/2018 
End 12/2021
 
Description Developing a novel eHealth and mHealth platform for the management of chronic disease; Health Guardian.
Amount £35,000 (GBP)
Funding ID BH135574 
Organisation National Institute for Health Research 
Department NIHR Newcastle Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 10/2014 
End 10/2019
 
Description Developing human cardiac precision cut slices as a novel platform for target identification and validation in Duchenne MD
Amount £82,405 (GBP)
Organisation Duchenne UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description EMBO Fellowship
Amount € 9,350 (EUR)
Organisation European Molecular Biology Organisation 
Sector Charity/Non Profit
Country Germany
Start 10/2019 
End 01/2020
 
Description EU Horizon 2020
Amount € 5,559,201 (EUR)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2018 
End 03/2021
 
Description Exploring USP30 expression in normal and mitochondrial disease tissues
Amount £42,379 (GBP)
Organisation MISSION Therapeutics 
Sector Private
Country United Kingdom
Start 10/2018 
End 02/2019
 
Description Industry research funding
Amount £2,557,789 (GBP)
Organisation Novartis 
Sector Private
Country Global
Start 04/2016 
End 06/2017
 
Description Intercept Pharmaceuticals Research Grant
Amount £22,745 (GBP)
Organisation Intercept Pharmaceuticals 
Sector Private
Country United States
Start 08/2015 
End 02/2016
 
Description Investigating the us of mtDNA mutations as predictors of response to preoperative radiotherapy in colorectal cancer
Amount £9,700 (GBP)
Organisation Bowel Disease Research Foundation (BDRF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 07/2019
 
Description Keystone Conference Travel Award - AV
Amount $1,200 (USD)
Organisation Keystone College 
Sector Academic/University
Country United States
Start 01/2019 
End 01/2019
 
Description MICA programme Grant Molecular Drivers of fibrosis at the hepatic epithelial-mesenchymal barrier
Amount £1,572,973 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 09/2023
 
Description MICA: Randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in patients with Mitochondrial Myopathy (AIMM)
Amount £1,684,631 (GBP)
Funding ID MR/R006458/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 10/2021
 
Description MORNINGSIDE Ventures
Amount £390,087 (GBP)
Organisation Morningside Venture Capital 
Sector Private
Country China
Start 10/2016 
End 09/2018
 
Description MRC Confidence in Concept
Amount £42,750 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2016 
End 01/2018
 
Description Mission Therapeutics
Amount £25,831 (GBP)
Organisation MISSION Therapeutics 
Sector Private
Country United Kingdom
Start 11/2016 
End 08/2017
 
Description Mitochondrial Biomarkers - Spring 2018 program
Amount $198,182 (USD)
Funding ID I5707 
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 05/2018 
End 05/2019
 
Description NIHR Biomedical Research Centre
Amount £39,550 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2017
 
Description NIHR Biomedical Research Centre
Amount £101,109 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 01/2016 
End 03/2017
 
Description NIHR Innovation Observatory (Accelerated Access activity and extension)
Amount £8,300,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2020 
End 02/2025
 
Description NIHR Senior Investigator Award
Amount £45,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2018
 
Description National Horizon Scanning Centre
Amount £8,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description National Horizon Scanning Centre
Amount £8,000,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Central Commissioning Facility
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Newcastle University Faculty matched funding
Amount £2,692,707 (GBP)
Organisation Newcastle University 
Sector Academic/University
Country United Kingdom
Start 06/2014 
End 06/2019
 
Description Newcastle University Research Fellowship
Amount £280,000 (GBP)
Organisation Newcastle University 
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 12/2021
 
Description Newcastle University Research Fellowship
Amount £280,000 (GBP)
Organisation Newcastle University 
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 12/2021
 
Description Reneo
Amount £282,956 (GBP)
Organisation Reneo Pharmaceuticals, Inc 
Sector Private
Country United States
Start 03/2018 
End 10/2018
 
Description Role of Mitochondrial Reactive Oxygen Species in Stress Adaptation during Ageing
Amount £289,487 (GBP)
Funding ID BB/M023311/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2015 
End 08/2018
 
Description Role of autophagy in the accumulation of defective mitochondria during ageing
Amount £328,975 (GBP)
Funding ID BB/R008167/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 04/2021
 
Description Science Communication Award
Amount £19,275 (GBP)
Organisation The Lily Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 04/2018
 
Description Senior Fellowship: ROS via RET - a redox regulated pathway to extend lifespan
Amount £1,512,586 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 12/2023
 
Description State of the art proteomics for Newcastle University
Amount £578,689 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 12/2024
 
Description Supplement to MICA Programme Grant
Amount £500,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 10/2018 
End 09/2023
 
Description The Applied NMJ Research Facility
Amount £746,328 (GBP)
Funding ID 208339/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 09/2020
 
Description Towards targeting neutrophils in hepatocellular carcinoma
Amount £1,700,000 (GBP)
Funding ID A23390 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Urology Foundation Studentship Scheme
Amount £50,000 (GBP)
Organisation Urology Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2015 
End 08/2016
 
Description Wellcome Trust Centre renewal
Amount £6,336,817 (GBP)
Funding ID 203105/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2017 
End 04/2022
 
Description Wellcome Trust Postgraduate Fellowship
Amount £300,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
End 06/2023
 
Title Blood-based epigenetic assay for detecting fibrosis 
Description We have developed a blood-based epigenetic assay for detecting fibrosis in patients with chronic liver disease. It is a very important methodological advance with likely future impact as a diagnostic. 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact The work has just been accepted for publication by the journal GUT. 
 
Title Immunohistochemistry to diagnose mitochondrial disease 
Description Improving the diagnosis of mitochondrial disease in muscle biopsies using a quadruple immunofluorescence technique 
Type Of Material Biological samples 
Year Produced 2015 
Provided To Others? Yes  
Impact This research method has been adopted in our diagnostic protocol. 
 
Title Mechanistic link between age associated mitochondrial DNA mutations and colon cancer providing new insights into colon cancer prevention and treatment 
Description We have shown that human colonic cancers have an excess number of age-associated clonally expanded mtDNA mutations compared to normal colonic epithelium. We generated an animal model that has high levels of mtDNA mutations and mitochondrial dysfunction in the intestinal epithelium, and shown that those crypts have undergone metabolic remodelling akin to the metabolic remodelling observed in intestinal cancer cells. When these cells are transformed the resulting tumours are grow more rapidly compared with tumours with normal mitochondrial function. Metabolomic analysis of tumour organoids derived from the mice show an upregulation of de novo serine synthesis and resistance to serine/glycine starvation. De novo serine synthesis is selected for during tumour progression to support cancer cell growth and proliferation, and our data show that normal ageing intestinal stem cells can undergo metabolic remodelling essentially priming them for tumour development. This work has been submitted to Nature. We have also investigated the mechanism of clonal expansion of mtDNA mutations in human colonic epithelium across the life-course using a combination of biological techniques and computational modelling. These data showed that, unlike muscle and other post-mitotic tissues, random genetic drift was the likely mechanism underlying clonal expansion in colonic stem cells. We also revealed fundamental insights into colonic stem cell biology in normal ageing humans such as the number of functional stem cells (5-7) and the stem cell replacement rate (0.52 per year) (Stamp et al. 2018). In addition, to try to explain the increased risk of colon cancer development in obese subjects, working across the Centre, we have measured mitochondrial function in human colonoscopic biopsies taken from obese subjects undergoing bariatric surgery and compared them with non-obese controls. We have found that obese individuals have a significantly higher proportion of colonic crypts with mitochondrial dysfunction compared with controls showing that environmental factors can influence mitochondrial function within the intestine. We have also used an animal model to investigate the effects of mitochondrial dysfunction in intestinal epithelial cells on the gut microbiome. We showed significant changes in the composition of the gut microbiome in the presence of high levels of mtDNA mutations, and that endurance exercise was able to modulate some of these changes (Houghton et al. 2018) 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact None yet 
 
Title New mechanism to explain the mitochondrial abnormalities causing age related deficiencies in post-mitotic human tissues such as muscle 
Description We have identified a new mechanism for the clonal expansion of mitochondrial DNA (mtDNA) deletions in skeletal muscle that we believe is highly likely to explain clonal expansion in all post-mitotic tissues. We observed focal perinuclear mitochondrial dysfunction in muscle of mitochondrial disease patients and aged individuals. Using a combination of high-resolution imaging and single cell genomics, we show that mtDNA deletions originate close to nuclei and that this facilitates the clonal expansion of these mutations, likely through enhanced mtDNA replication (Vincent et al. 2018). Using state-of-the-art 3D electron microscopy capable of high-resolution volume imaging of mitochondria, we demonstrated that mitochondrial branching appears to facilitate the spreading of mitochondrial dysfunction and mtDNA mutations through a muscle fibre and provides the first quantitative analysis of mitochondrial morphology in human muscle (Vincent et al. 2019). This work, along with our transmission EM work, is the first to demonstrate 'Mitochondrial Nanotunnels', thin tubules connecting adjacent mitochondria, which are increased in muscle from aged individuals (Vincent et al. 2016). We also show that clonal expansion leading to mitochondrial dysfunction is important in Inclusion Body Myositis (IBM) is an inflammatory and age related myopathy that gives important insights into healthy ageing and sarcopenia (Rygiel et al. 2015). We have shown that there are extensive mitochondrial defects, complex mtDNA rearrangements and mtDNA clonal expansion. We have also shown clear link between the inflammatory and mitochondrial changes. Clonal expansion of mtDNA deletions also occurs with ageing and we have quantitatively assessed mitochondrial respiratory chain deficiency in an elderly cohort demonstrating that complex I deficiency is significantly correlated with physical performance (Dodds et al. 2019). 
Type Of Material Biological samples 
Year Produced 2016 
Provided To Others? Yes  
Impact Not known 
 
Title Using 3D microscopy to understand mitochondrial status in muscle in ageing and disease 
Description We use 3-D electron microscopy capable of high resolution imaging of mitochondria to demonstrate that mitochondrial branching appears to facilitate the spreading of mitochondrial dysfunction and mtDNA mutations through a muscle fibre and provides the first quantitative analysis of mitochondrial morphology in human muscle. This work along with transmission EM work is the first to demosntrate 'Mitochondrial Nanotunnels', thin tubules connecting adjacent mitochondria, which are increased in muscle from aged individuals. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact This work will inform clinical trial outcome measurements. 
 
Title Mito Disease Cohort UK 
Description A database of around 1503 patients with mitochondrial disease, 964 of which were collected in Newcastle. 
Type Of Material Database/Collection of data 
Year Produced 2011 
Provided To Others? No  
Impact All patient data collected is being used to develop clinical guidelines and enrolment in clinical trials. 
 
Description AV visit to Helsinki 
Organisation University of Helsinki
Country Finland 
Sector Academic/University 
PI Contribution Dr Amy Vincent, a Research Associate in our Centre, is collaborating closely with Professor Anu Suomaleinen in Helsinki using the deletor mice as a model for clonal expansion. As part of this work Dr Vincent spent two weeks working with the mice in Professor Suomaleinen's laboratory in Helsinki. This work is still ongoing. Our research associate has applied for a Henry Wellcome fellowship which includes a period of 6 months working with the mouse model in Professor Suomalainen's group. The research associate has also performed two experiments as a contribution towards ongoing work in Helsinki.
Collaborator Contribution Professor Suomaleinen's laboratory hosted our Research Associate for two weeks where she learned techniques to work with the mouse tissue. Further collaborative work is planned. They have also agreed to host the research associate for a period of six months and to collaborate on a number of ongoing projects and offered advice and support in the writing of funding applications for this work.
Impact none yet, though it is expected several published papers will be produced from this research.
Start Year 2017
 
Description Abbvie clinical and pre-clinical studies on NAFLD 
Organisation AbbVie Inc
Country United States 
Sector Private 
PI Contribution My team will perform all experimental investigations, bioinformatic analyses, data analyses and presentations.
Collaborator Contribution Funding only
Impact This collaboration will address three project aims: 1. To develop a novel in-house precision cut liver slice bioreactor system for developing a human model of NAFLD. 2. To develop a hanging-drop culture system for studying cell-cell interactions in human NAFLD. 3. To exploit a novel rodent model of epigenetic adaption to liver fibrosis for discovering novel fibrosis-regulating pathways.
Start Year 2016
 
Description Bactevo 
Organisation Bactevo Limited
Country United Kingdom 
Sector Private 
PI Contribution Once "hits" are confirmed in their models, we will will investigate these further for efficacy in patient cell lines.
Collaborator Contribution Bactevo are a SME who are currently screening their library of natural compounds to look for novel molecules that increase mitochondrial mass. Once "hits" are confirmed in their models, the MRG will investigate these further for efficacy in patient cell lines.
Impact No outcomes yet
Start Year 2016
 
Description Collaborating on the UK Biobank 
Organisation University of Sydney
Country Australia 
Sector Academic/University 
PI Contribution We are collaborating with the Sydney Univeristy on the analysis of the UK Biobank dataset. They have expertise on epidemiology and we have expertise in lifestyle.
Collaborator Contribution They have provided staff time (statisticians) and also hosted post-docs.
Impact We have one paper in press with BMJ open and one under review in the International Journal of Obesity. The collaboration has also added other groups (such as IBM).
Start Year 2015
 
Description Collaboration with UCL 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in muscle disease and sarcopenia. This is close working between two MRC Centres. Professor Hanna directs the MRC Translational Centre for Neuromuscular Disorders
Collaborator Contribution Expertise in muscle disease
Impact Joint conference on Neuromuscular diseases
Start Year 2008
 
Description Health Economics - Luke Vale 
Organisation Newcastle University
Department Institute of Health and Society
Country United Kingdom 
Sector Academic/University 
PI Contribution We are developing a joint NIHR HTA application, integrating the health economics aspect and cost-effectiveness analysis into a project to improve the diagnosis of heart failure in primary care.
Collaborator Contribution Professor Luke Vale is an expert in health economics, providing guidance and support as a co-investigator on the project.
Impact none yet
Start Year 2015
 
Description Improving diagnosis and monitoring of heart failure in primary care 
Organisation University of Oxford
Department Nuffield Department of Primary Care Health Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution One of our Centre co-investigators developed a project on improving diagnosis and monitoring of heart failure in primary care for submission to the NIHR Career Development Fellowship Programme and European Research Council Starting Grant. Work is ongoing to develop a full application for NIHR Health Technology Assessment funding jointly between Oxford and Newcastle.
Collaborator Contribution Professor Richard Hobbs, an expert in this area, provided mentorship on the application and the collaboration will hopefully continue if funding is confirmed.
Impact none yet
Start Year 2015
 
Description Kings College London 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We have hosted Dr Julien Ochala to work with us in our laboratory on our tissues to teach us some of his techniques for muscle strength testing and myonuclear domain size analysis in mitochondrial disease patients. Our research associate has been performing experiments under the guidance of Dr Ochala. These ongoing experiments have formed part of a fellowship application submitted by our research associate.
Collaborator Contribution Dr Ochala has shared his techniques with us. Dr Ochala has visited Newcastle twice in order to start and continue the collaboration, training the research associate to perform a technique developed in his lab which is now being applied to samples in Newcastle.
Impact none yet, but research papers are planned.
Start Year 2017
 
Description Leeds University - Dr Paolo Actis 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Our research associate co-supervises a MRC DiMEN funded PhD student with Dr Actis and has been down to Leeds to discuss the work of the PhD student. In addition our research associate is working on a grant application to further this collaboration.
Collaborator Contribution Dr Actis has developed a piece of technology which is being applied by our research associate and the PhD student to samples from Newcastle. The technique holds great promise and funding applications for further work are being prepared together with Dr Hudson (Newcastle) and Professor Turnbull.
Impact MRC DiMEN funded PhD studentship
Start Year 2018
 
Description Liverpool Univeristy CIMA 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating with Liverpool University as part of the MRC / ARUK Centre for Integrated Musculoskeletal Ageing on a study looking at sedentary behaviour and muscle ageing.
Collaborator Contribution Both sites are contributing clinical facilities and support.
Impact Research still active.
Start Year 2013
 
Description Liverpool University CIMA 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution We are collaborating with Liverpool University as part of the MRC/ARUK Centre for Integrated Musculoskeletal Ageing on a study looking at sedentary behaviour and muscle ageing.
Collaborator Contribution Both sites are contributing clinical facilities and support.
Impact no impact yet
Start Year 2013
 
Description Max Planck Institute 
Organisation Max Planck Society
Department Max Planck Institute for the Biology of Ageing
Country Germany 
Sector Academic/University 
PI Contribution assessment of the use of mitochondrial mutator mouse as a model of stem cell aging and development of a mouse model of a human mitochondrial myopathy. We have carried out comprehensive histochemical and molecular analysis of gut tissues at the single cell level. We are now performing single cell analyses of gut tissue from a mouse model of disease being developed at the Max Planck Institute.
Collaborator Contribution The collaborators provided heterozygous mutator mice.
Impact One publication in Mechanisms of Ageing and Development, 2014
Start Year 2011
 
Description Mission Therapeutics 
Organisation MISSION Therapeutics
Country United Kingdom 
Sector Private 
PI Contribution We are researching to find new drugs to treat mitochondrial disease.
Collaborator Contribution Mission are part-funding a PhD student
Impact No outcomes yet
Start Year 2016
 
Description NUTRIM 
Organisation Maastricht University (UM)
Department School for Nutrition, Toxicology and Metabolism (NUTRIM)
Country Netherlands 
Sector Academic/University 
PI Contribution We are supporting direct measurements of liver glycogen by NMR.
Collaborator Contribution Expertise on exercise and nutrition.
Impact None yet.
Start Year 2013
 
Description Novartis-funded study to assess the effect of serelaxin 
Organisation Royal Brompton & Harefield NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution We have coordinated and led the Novartis funded, multinational, multicentre, randomized, double-blind, crossover placebo controlled Phase II study to assess the effect of Serelaxin versus placebo on high-sensitivity cardiac troponin I (hs-cTnI) rlease in patients with chronic heart failure after exercise for the Newcastle site.
Collaborator Contribution Professor John Cleland from Imperial College and the Royal Brompton and Harefield Trust is one of the UK's leading clinical academic cardiologists with a special interest in heart failure. He is Chief Investigator for the study in the UK.
Impact none yet
Start Year 2015
 
Description Novel test for improving diagnosis of heart failure in primary care 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution I applied and received MRC Confidence in Concept project grant aiming to develop and evaluate a novel test to improve diagnosis of heart failure in primary care. Newcastle team initiated the project, collected preliminary data and led preparation and submission of the NIHR EME applications of two publications i.e. Charman et al. ESC Heart Failure (2018, 5(4):703-712), and Charman et al. BMJ Open (under review 08/12/18), as per below.
Collaborator Contribution Professors Hobbs and Mant provided advice and expertise as co-applicants in preparation and submission of the NIHR EME Grant in 2017, and will contribute as co-applicants in re-submission in 2019. They critically reviewed and approved submission of the two manuscripts prepared and provided primary care expertise in the project development and writing.
Impact i) Charman SJ, Okwose NC, Stefanetti RJ, Bailey K, Skinner J, Ristic A, Seferovic PM, Scott M, Turley S, Fuat A, Mant J, Hobbs FDR, MacGowan GA, Jakovljevic DG. A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care. ESC Heart Failure 2018, 5(4):703-712. ii) Charman SJ, Okwose NC, Maniatopoulos G, Graziadio S, Metzler T, Banks H, Vale L, MacGowan GA, Seferovic PM, Fuat A, Deaton C, Mant J, Hobbs FDR, Jakovljevic DG. Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: a qualitative study. BMJ Open (under review 08/12/18). - It is a multi-disciplinary collaboration including: primary care research experts, physicians, clinical physiologists, research methodologist, and health economy experts.
Start Year 2016
 
Description Reneo 
Organisation Reneo Pharmaceuticals, Inc
Country United States 
Sector Private 
PI Contribution Researching into new drugs to treat mitochondrial disease
Collaborator Contribution Development of experimental compounds. Reneo are also funding a Research Associate and Research Assistant to test the new compounds in our laboratory.
Impact None yet
Start Year 2017
 
Description UCL - Dr Francesco Saverio Tedesco 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Our research associate has submitted a Henry Wellcome application containing work for which she would travel to Dr. Tedescos lab to learn a technique developed by Dr Tedesco's group.
Collaborator Contribution Dr Tedesco is starting to optimise methods for further development of the model.
Impact None yet
Start Year 2017
 
Description University of Oregon 
Organisation University of Oregon
Country United States 
Sector Academic/University 
PI Contribution We are sharing knowledge and techniques with Dr Roderick Capaldi's laboratory to develop a panel of antibodies for signalling and metabolism.
Collaborator Contribution Dr Capaldi's and his team are working closely with us to develop a panel of antibodies for signalling and metabolism.
Impact none yet
Start Year 2017
 
Description Within European Union's Horizon 2020 research and innovation programme under grant agreement No 777204 for the project SILICOFCM (www.silicofcm.eu) led by Professor Nenad Filipovic, University of Kragujevac, Serbia. As the lead and coordinator for WP3 I collaborate closely with Professors Iacopo Olivotto (University Hospital Florence, ITA), Lars Maier (University Hospital Regensburg, DE), Philippe Charon (University Hospital Pitié-Salpêtrière, Paris), Lazar Velicki (University Hospital Novi Sad 
Organisation European Commission
Department Horizon 2020
Country European Union (EU) 
Sector Public 
PI Contribution - I participated in preparation, writing up and submission of successful grant application to the EU Horizon2020 multi-national proposal as a leader and co-ordinator of WP3: Clinical studies in patients with hypertrophic cardiomyopathy. I designed, received approvals and implemented across the five EU centres indicated above the research protocol "Clinical and genetic determinants of disease progression and response to pharmacological and lifestyle interventions in patients with hypertrophic cardiomyopathy".
Collaborator Contribution Professor Filipovic is the chief investigator and main coordinator of the SILICOFCM project. Five clinical partners including Newcastle (coordinator for clinical WP), Florence, Paris, Regensburg, Novi Sad) deliver at their institution the three tasks defined within the WP3 i.e. retrospective study, prospective study, and genetic testing.
Impact Okwose NC, Avery L, O'Brien N, Cassidy S, Charman SJ, Bailey K, Velicki L, Olivotto I, Brennan P, MacGowan GA, Jakovljevic DG. Acceptability, feasibility and preliminary evaluation of a novel, personalised, home-based physical activity intervention for chronic heart failure (Active-at-Home-HF): A pilot study. European Journal of Preventive Cardiology (under review 08/12/18). ii) Wibowo PG, Charman SJ, Okwose NC, Velicki L, Popovic D, Hollingsworth KG, MacGowan GA, Jakovljevic DG. Cardiac high-energy phosphate metabolism is not associated with measures of whole body metabolism in healthy female adults. American Journal of Cardiology (under review 08/12/18). iii) Andric S, Tesic D, Somer D, Srdanovic I, Miljkovic T, Jakovljevic DG, Velicki L. Ventriculoatrial synchrony induced heart failure. Acta Clinica Belgica. 2018 Dec;73(6):439-443. - It is a multi-disciplinary collaboration including: clinicians, molecular biologists, geneticists, bioinformaticians, medical physicists, computer scientists, and engineers.
Start Year 2018
 
Title A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Daily Subcutaneous Injections of Elamipretide in Subjects with Primary Mitochondrial Myopathy Followed by an Open-Label Treatment Extension 
Description SPIMM-301 has two parts. In part 1, which will have a duration of 24 weeks, participants will be randomised to elamipretide or placebo (double blinded). Part 2 is an open-label extension- with a duration of 144 weeks. Funding for this trial is provided by Stealth BioTherapeutics Inc., the trial Sponsor. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact The SPIMM 301 study has the potential to result in a treatment for primary mitochondrial myopathy, at present there are no available treatments for this condition. 
 
Title Acipimox in Mitochondrial Myopathy (AIMM) Study 
Description The aim of the AIMM study is to repurpose the drug acipimox for use in a new indication, namely treatment of patients with mitochondrial myopathy. Acipimox is a niacin derivative and nicotinic acid analogue with activity as a hypolipidaemic agent- it was originally developed and licensed to treat high cholesterol and improve diabetic control. Acipimox has been shown to boost ATP levels within muscle cells and it is this function that we are looking use in order to relieve the debilitating muscle symptoms experienced by some patients with mitochondrial disease and muscle involvement. The AIMM trial is funded via the MRC Biomedical Catalyst Development Pathway Funding Scheme (DPFS). 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Under active development/distribution
Impact None yet-still in development however it will target a rare disease or difficult to reach population. Success of this study will potentially impact most on patients with mitochondrial disease, as it may provide a novel therapeutic strategy, in a condition with no currently licensed treatments. If Acipimox demonstrates significant efficacy in the two forms of mitochondrial disease included in this study design, the compound is likely to be beneficial for all forms of mitochondrial disease with significant muscle involvement. Randomized clinical trials and evidence-based studies on the efficacy of treatments in patients with mitochondrial disease is still lacking. In the clinical field of mitochondrial disease, this work will advance future trial design by linking several functional outcome measures with optimized clinical assessments. We would also propose extrapolating the adaptive design methodology into other rare diseases where obtaining the desired patient recruitment and retention proves to be the primary barrier to clinical advancements. The trial will also allow for further refinement of a number of functional outcome measures. 
 
Title Home-based physical activity intervention 
Description We have designed and evaluated a home-based physical activity intervention to improve function and quality of life in those living with heart failure. 
Type Therapeutic Intervention - Physical
Current Stage Of Development Small-scale adoption
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact none known 
 
Title Novel test to improve early detection of heart dysfunction 
Description Heart failure is a consequence of cardiovascular ageing.. Early diagnosis of cardiac dysfunction improves length and quality of life. In order to facilitate early diagnosis, we have developed a novel cardiac output response to stress test to improve diagnostic accuracy of heart failure in primary care (Charman et al. 2018). 
Type Preventative Intervention - Behavioural risk modification
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2018
Development Status Under active development/distribution
Impact none known 
 
Description "Using pre-clinical models to study the inflammation-fibrosis-cancer axis and test novel therapies" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Presentation at the Newcastle University Welfare meeting of preclinical model and 3Rs approaches to reduce animal use.
Year(s) Of Engagement Activity 2018
 
Description 13th European Nutrition Conference - FENS 2019 "Malnutrition in an Obese World: European Perspectives". "Dietary interventions to promote healthier ageing". Dublin 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on dietary intervention to enhance healthy ageing. This has led to a joint publication with other presenters in this session.
Year(s) Of Engagement Activity 2019
URL http://www.fens2019.org/
 
Description ABN 2015 Harrogate 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker at the Annual Meeting of the Association of British Neurologists 2015 in Harrogate
Year(s) Of Engagement Activity 2015
URL http://www.theabn.org/news/abn-annual-meeting-2015.html
 
Description APPG Houses of Parliament 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Gave evidence to the APPG on Health about the proposed changes to the law to allow IVF procedures that will help to reduce the risk of passing on mitochondrial disease to children.
Year(s) Of Engagement Activity 2015
 
Description AgriFood Training Partnership annual conference 'Interventions to keep people healthy and independent into old age: opportunities for industry' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact More than 100 participants attended the lecture. This led to discussion with several research groups afterwards.
Year(s) Of Engagement Activity 2018
 
Description Annual Dairy Council Nutrition Lecture - 30th Anniversary Symposium. "Nutrition research challenges in the next 30 years". Coleraine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited lecture of research priorities in nutrition in the next 30 years
Year(s) Of Engagement Activity 2019
 
Description Autumn meeting of the Association of British Neurologists 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker at the Autumn 2015 meeting of the ABN in London.
Year(s) Of Engagement Activity 2015
URL http://www.theabn.org/media/2015%20London%20ABN%20programme%20final%2024%20June%202015.pdf
 
Description BASL basic science retreat 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact I organised the BASL basic science retreats in 2018 and 2019 in Derbyshire. The next meeting will be Plymouth 2020. Meeting is for post graduates/PhD students, research associates, fellows, clinical fellows and both basic and clinical academics interested in liver research.
Year(s) Of Engagement Activity 2018,2019
URL http://www.basl.org.uk/uploads/Basic%20Science%20Retreat%202019%20-%20Programme.pdf
 
Description BBC Documentary on Ageing 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact I led a three part documentary for the BBC on how to Age Well that was broadcast in 2017 and watched by in excess of 12million people in the UK and 5million overseas.
Year(s) Of Engagement Activity 2017,2018
URL http://www.bbc.co.uk/programmes/articles/2YTnV1QS0l6Gbkyf0FcKhM3/test-your-lifestyle-how-are-you-age...
 
Description BBC Documentary on Sugar 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I wrote, helped deliver and coordinated a documentary series with the BBC on sugar. We delivered an intervention to help people who take in too much sugar to help them reduce. The documentary was delivered globally under licence from the BBC. Significant media interest about sugar.
Year(s) Of Engagement Activity 2015
URL http://www.bbc.co.uk/programmes/b05n2bn7
 
Description BBC Documentary on cognition 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I helped write, coordinate and deliver a BBC documentary looking at cognition and the role of lifestyle for the Trust Me I am a Doctor series.
Year(s) Of Engagement Activity 2015
URL http://www.bbc.co.uk/programmes/articles/54MwYnJLNvbHbT5KsBRg9Tv/the-big-brain-maintenance-experimen...
 
Description Blue Dot Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Research Associates and postgraduate students from our Centre organised and manned a stand at the Blue Dot Festival at Jodrell Bank in July 2017 showcasing our research into mitochondrial disease.
Year(s) Of Engagement Activity 2017
URL https://www.discoverthebluedot.com/news_article/thank-you-2017!
 
Description Bluedot Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Some of our postdoctoral researchers worked with artists from Newcastle University to create an exhibit at the Bluedot Festival.
At the Festival, they set up and manned a stand which aimed to demonstrate research to a wide audience using the medium of art. They interacted with festival goers conducting practical activities with them to communicate the importance of mitochondrial research.
Year(s) Of Engagement Activity 2019
URL https://www.discoverthebluedot.com/lineup/2019
 
Description Brilliant Club Tutor 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact The Brilliant Club is a charity with the aim of increasing the number of students from under-represented backgrounds at highly selective universities. One of our PhD students delivers weekly tutorials to KS4 and KS5 school children and the children write an assignment at the end. The PhD student who delivered the tutorials marks the assignments and the children are invited to Newcastle University for a graduation ceremony.
Year(s) Of Engagement Activity 2018,2019
URL https://thebrilliantclub.org/the-brilliant-club-for-schools/our-work/
 
Description British Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Schools
Results and Impact We led an interactive workshop for the public on ageing and lifestyle.

Public awareness of science and engaging children in science.
Year(s) Of Engagement Activity 2013
URL http://www.britishscienceassociation.org/british-science-festival/newcastle-2013
 
Description Cell Detectives 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact some of our PGR students and postdoctoral researchers organised a workshop at the International Centre for Life in Newcastle to showcase the facilities of the bioimaging unit used in our research at Newcastle University. the event was aimed at children visiting with their parents and we tried to communicate the science and the equipment in a fun and understandable way through various different activities.
Year(s) Of Engagement Activity 2019
URL https://twitter.com/scienceatlife/status/1163390171783553024/photo/1
 
Description DMT - Invited speaker at MEET event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker at the final dissemination event for the Mitochondrial European Educational Training group.
Year(s) Of Engagement Activity 2016
 
Description DMT Christmas Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact The Children's Christmas Lecture is an annual event sponsored by Newcastle University with high profile speakers. The Centre Director was invited to present the lecture in 2016. Over 300 school children and around 50 representatives of the 'Voice North' panel were invited to attend. This was an interactive lecture about mitochondrial disease, how it affects people and what we hope to achieve with our research.
Year(s) Of Engagement Activity 2016
 
Description DMT Invited speaker at UCL ION meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker at the annual Institute of Neuroscience conference, UCL
Year(s) Of Engagement Activity 2016
 
Description DMT Mitochondrial Medicine: Developing New Treatments for Mitochondrial Disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact invited speaker at the Wellcome Mitochondrial Medicine meeting at Hinxton Cambridge in May
Year(s) Of Engagement Activity 2016
URL http://www.globaleventslist.elsevier.com/events/2016/05/mitochondrial-medicine-developng-new-treatme...
 
Description DMT NIHR Summer Camp Ashbridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited speaker at the NIHR Training Camp in Ashridgge
Year(s) Of Engagement Activity 2016
 
Description DMT RCPH Liverpool 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker at the annual RCPH conference in Liverpool
Year(s) Of Engagement Activity 2016
URL http://www.rcpch.ac.uk/sites/default/files/user158/RCPCH-2016-annual-conference-programme.pdf
 
Description Engage Conference Bristol 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Engage conferences are aimed at Universities and are designed to help researchers find better ways of involving people from outside academia in conceiving, shaping, producing and applying powerful research?
Year(s) Of Engagement Activity 2015
URL https://www.publicengagement.ac.uk/events/engage-conference-2015
 
Description Fit as a Falcon 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact This was an activity day held in conjunction with Newcastle Falcons Rugby Community Foundation for school children around the region. Approximately 300 school children participated in interactive activities throughout the day. The activities were organised by postgraduate students and young researchers from the Centre. The event was visited by a local Newcastle MP.
Year(s) Of Engagement Activity 2018
 
Description Fit as a Falcon 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact An activity day attended by over 100 school children showcasing the four themes of the Centre. The day was organised in collaboration with Newcastle Falcons Community Foundation and built on work they were already doing with schools in the area. The activities were designed to show how a healthy lifestyle when we are younger affects the way we age, focusing on exercise and nutrition.
Feedback from the children, teachers and students and scientists involved in the event was very positive. It also worked well from the Falcons perspective and they have asked us to make this an annual event. There will also be opportunities to be involved with other engagement programmes that the Falcons Community foundation are running.
Year(s) Of Engagement Activity 2016
 
Description Fit as a Falcon 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Approximately 500 schoolchildren attended an event held at the Newcastle Falcons Rugby Club over two days. Our students and postdoctoral researchers demonstrated different aspects of our research using various activities. The Falcons Rugby Community Foundation team also hosted an activity. The children moved around the different activities and participated in them all. On the second day running alongside our event, there was an event organised in conjunction with Greggs Bakery around their 'Tackling Health' initiative teaching about healthy cooking and eating. Other local business people were invited to this event so they were also able to visit our activities and engage with the researchers.Feedback from the children was extremely positive and they all enjoyed the day. We also had excellent feedback from our students and researchers about how much they had gained from participating in the engagement event.
Year(s) Of Engagement Activity 2017
 
Description Fit as a First School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A number of our researchers organised an interactive activity afternoon at a local first school. About 90 school children aged 7-9 took part in a number of activities to learn about the importance of a healthy diet and exercise and how our bodies make energy. The children evaluated the day using emoji stickers. The event proved so popular we ran out of the smiley face stickers! As an added bonus, the research students who organised and ran the event all commented on how much they had enjoyed themselves.
Year(s) Of Engagement Activity 2019
URL https://www.newcastle-mitochondria.com/fitness-is-fun/
 
Description HNRC 25th Anniversary Conference. "Global Nutrition Challenges in the next 25 years". Newcastle upon Tyne, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Review of research priorities in nutrition in next 25 years.
Year(s) Of Engagement Activity 2019
 
Description ICM Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Demonstration of cardiopulmonary exercise testing to school children at an Institute Open Day. About 50 children attended the day.
Year(s) Of Engagement Activity 2015
 
Description Invited Speaker: 15th EuGMS Annual Congress. "Towards a multidimensional healthy ageing phenotype". Krakow, Poland 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation of work towards a panel of biomarkers for assessing healthy ageing
Year(s) Of Engagement Activity 2019
URL https://www.eugms.org/2019.html
 
Description Invited keynote speaker - Tissue inflammation and organ fibrosis 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Professor Oakley was invited as a Keynote speaker to present research entitled -"Tissue inflammation and organ fibrosis" at the MIDAS - Mechanisms of Inflammation Symposium at Birmingham University on the 4th October 2019.
Year(s) Of Engagement Activity 2019
 
Description Invited speaker BASL basic science meeting - 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited speaker at the BASL basic science symposia, 2019.
Year(s) Of Engagement Activity 2019
URL http://www.basl.org.uk/uploads/Basic%20Science%20Retreat%202019%20-%20Programme.pdf
 
Description Invited speaker at the 38th European Workshop on Rheumatology Research, Geneva. Title of talk "Fibrogenic inflammatory cross-talk in post-total knee arthroplasty - a human model of induced chronic fibrosis 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The intended purpose was to present a talk in a session entitled "fibrosis" aimed at educating the european rheumatology field on recent advances in fibrosis research of relevance to their field. I presented on collaborative work that we have carried out with orthopaedic surgeons at Newcastle NHS Trust Hospitals on the fibrotic complications of total knee replacement which can result in up to 10% of patients suffering pain, swelling and loss of motion of their joint. The talk was extremely well received and will be followed by invitations to give further presentations on the subject. The talk was 'tweeted' by Nature Rheumatology.
Year(s) Of Engagement Activity 2018
URL http://www.ewrr.org
 
Description Leading Edge 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Visits by groups of school children to our research laboratories as part of the 'Leading Edge' initiative to help students grasp basic scientific techniques and provide an insight into our research activities.
Year(s) Of Engagement Activity 2017
URL https://blogs.ncl.ac.uk/leadingedge/
 
Description Lecture at Surrey University. "Dietary strategies for longevity and reduced risk of age-related diseases". Surrey University, Guildford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Lecture on dietary strategies for longevity and reduced risk of age-related diseases
Year(s) Of Engagement Activity 2019
 
Description Lily Family Weekend 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Activity showcasing our research into mitochondrial disease at the Lily Foundation Family Weekend in July 2018
Year(s) Of Engagement Activity 2018
 
Description MRC festival of Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact As part of the MRC festival of research we organised an event in collaboration with Newcastle Falcons to highlight the research we do as part of the Centre for Ageing and Vitality.
Year(s) Of Engagement Activity 2016
URL https://www.youtube.com/watch?v=TPGTWs7xw20
 
Description Meet the Scientist 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact One of our postdocs hosted a stand at the Newcastle International Centre for Life explaining aspects of mitochondrial research.
Year(s) Of Engagement Activity 2018
URL https://www.life.org.uk/
 
Description Minimed school 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Mini medical school presentation entitled "love you liver and it will love you". The 2 hour interactive lecture given by a mixture of basic scientists and clinical hepatologists gave an overview of the different types of liver disease and how they develop.
Year(s) Of Engagement Activity 2016
URL http://www.ncl.ac.uk/medicalsciences/mini-medical-school/
 
Description Move Like A Pro 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Move Like A Pro is a 12-week programme funded by Premiership Rugby and Movember to encourage middle-aged men who are not particularly active to adopt a healthier lifestyle. One of our researchers presented her research on how being active affects healthy ageing to the group towards the end of the programme. The talk was well received and we have been asked to provide input to future rounds of the programme
Year(s) Of Engagement Activity 2016
URL https://movelikeapro.co.uk/
 
Description NC3R workshop "NC3Rs David Sainsbury Seminar Series: What is the future of 3Rs research?" 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact presented a talk entitled "Modelling disease in organotypic precision cut slices using novel bioreactor technology" at the NC3Rs David Sainsbury Seminar Series: What is the future of 3Rs research? held at Newcastle University 11/10/2016
Year(s) Of Engagement Activity 2016
 
Description Newcastle Nutrition Course 2018. 'Nutrition and ageing: State of the Art' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Following this lecture, there were several discussions with attending medical practitioners.
Year(s) Of Engagement Activity 2018
 
Description Nu-AGE undergraduate module with public involvement 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact lectures and workshops with undergraduate students and older members of the public regarding ageing research being undertaken at Newcastle University
Year(s) Of Engagement Activity 2014,2015,2016
URL http://www.ncl.ac.uk/ageing/teaching/undergrad/nu-age/
 
Description OK to ask campaign 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact The NIHR 'Ok to ask' campaign aims to encourage patients or carers to ask about research opportunities that could be available to them or their families. We took part in this campaign by holding a stall outside of the Medicinema within the The Great North Children's Hospital. It gave members of the public an informal opportunity to chat to some of our researchers and ask questions about our research.
Year(s) Of Engagement Activity 2016
URL http://www.newcastle-mitochondria.com/ok-to-ask-campaign-2/
 
Description One day workshop - fit as a falcon about ageing, inflammation, fibrosis 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact This was part of the MRC science festival looking at healthy ageing. Our station highlighted diseases where inflammation and fibrosis effected different organs of the body (including skin).
Year(s) Of Engagement Activity 2016
URL https://www.youtube.com/watch?v=TPGTWs7xw20
 
Description Palace of Science March 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Stand of science-inspired art and researchers talking about their work as part of brain awareness week.
Year(s) Of Engagement Activity 2018
URL https://www.skiddle.com/whats-on/Newcastle-on-Tyne/Wylam-Brewery/Palace-of-Science/13169471/
 
Description Patient Engagement Meeting - Total Knee Replacement group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact A patient engagement evening for patients and their families who have had total knee replacement surgery and are now experiencing stiffness, swelling and pain in the joint. The aim of the meeting was to inform them about fibrosis and how we think the scars forming in their joint are contributing to the condition. The majority of the audience (about 90%) were 50+.
The event was very successful and we are awaiting formal feedback from the group.
Year(s) Of Engagement Activity 2015
 
Description Patient Information Day 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Over 100 patients, families and their carers attended an all day meeting in October 2016. There were talks from professional practitioners, information stands and engagement activities as well as patient focus groups. There was also an informal evening event which offered patients and their families and carers an opportunity to interact with other people affected by mitochondrial disease.
Year(s) Of Engagement Activity 2016
URL http://www.newcastle-mitochondria.com/patient-day-2016/
 
Description Presentation to Peers in the Houses of Parliament 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Discussion with peers at the Houses of Parliament prior to the vote on changing the law to allow mitochondrial donation.
Year(s) Of Engagement Activity 2015
 
Description Progress Educational Trust meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk at the PET annual confrence. The 2015 annual conference of the Progress Educational Trust (PET) focused on the advent of new methods of making enduring changes to the human embryo - changes that, if used in treatment, will affect not only the person born but also subsequent generations.
Year(s) Of Engagement Activity 2015
URL http://www.progress.org.uk/conference2015
 
Description Science on a plate 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact Schools open day of lectures and interactive tasks.

Links with schools and motivating the next generation of scientists!
Year(s) Of Engagement Activity 2013
 
Description Society for Endocrinology conference 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker at the annual Society for Endocrinology Conference in Cologne,Germany.
Year(s) Of Engagement Activity 2015
URL http://Cecad.uni-koeln.de
 
Description Stemette Event - SAGE Gateshead 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Two postdocs gave talks to around 300 schoolgirls about careers in science and the digital economy.
Year(s) Of Engagement Activity 2015
URL https://stemettes.wordpress.com/tag/sage-gateshead/
 
Description The Rank Prize Funds Mini-Symposium on Malnutrition Through the Life Course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This invitation only workshop led to new interactions between two research communities (those interested in childhood malnutrition and those researching malnutrition in later life).
Year(s) Of Engagement Activity 2018
 
Description Translational Aging Research: Challenges and Opportunities, Lorentz Centre workshop, Amsterdam 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Contributed to development of strategy for research in ageing in The Netherlands
Year(s) Of Engagement Activity 2016
 
Description institute of Education London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker at the Institute of Education London on 10 September 2015
Year(s) Of Engagement Activity 2015