Mesenchymal Stem Cell (MSC) regulation of pulmonary macrophage populations in Acute Respiratory Distress Syndrome (ARDS).

Lead Research Organisation: Queen's University of Belfast
Department Name: Centre for Experimental Medicine

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a severe clinical syndrom that affects 20% of all critically ill patients in intensive care. Unfortunately, around 30-50% of these people will die from the condition and the quality of life of the survivers can be seriously reduced due to the consequent chronic lung problems.There is no effective treatments for this condition at this time and therefore new medicines are urgently needed. ARDS is characterised by an excessive and disregulated inflammation in the lung that leads to inappropriate infiltration of immune cells, lungs fill with water and fail to maintain its main function - breathing. In order to breath these patients require mechanical ventilation.
ARDS results from multiple causes, although pneumonia induced ARDS is the most common and the most devastating. Inflammation is the way in which the body reacts to infection, irritation or other injury. Normally, inflammation is one way the body heals and copes with the infection, however, when disregulated in certain condition such as ARDS it can lead to severe damages and impair of the the lung function. Immune cells called macrophages have increasingly been recognized to play a key role in the development and resolution of ARDS functioning as a coordinators of inflammatory responses. Recently more and more attention of clinicians and basic scientists working in the field of ARDS research is drawn to cell-based therapies. A key advantage of cell based therapy compared to pharmacologic treatment is that cells can actively respond to the local microenvironment and exert multiple beneficial effects, modulating several injurious and reparative pathways in this complex disease process.
One of the most promising candidate for a cell based therapy for ARDS are cells termed Mesenchymal Stem Cells (MSC), which represent one kind of adult stem cells (can be easily isolated from tissues of adult patients or healthy volunteers), because of this there is no ethical issues that are related to use of embryonic tissues. MSC could easily be propagated and manipulated under laboratory conditions and have capacity to differentiate into multiple different cell types of the body. Importantly, long term research has shown their safety in terms of developing tumors.
Multiple preclinical animal studies conducted by our group as well as by other investigators showed that MSC indeed have protective effect when administered as a treatment for ARDS. Among several beneficial effects, their administration always is associated with drastically reduced inflammation, however the mechanisms of this phenomenon are still unclear and data on their interaction with the immune cells of the lung remain unsufficient and controversial. To translate MSC into the clinical practice it is essential that we have more precise understanding of their mechanism of action.
The main question we are keen to address in the proposed research is: how MSC treatment influence the lung macrophages? What alterations do MSC induce in their functions and what molecular mechanisms mediate those changes.
Based on our preliminary data and results from other studies we have reasons to hypothesize that MSC will promote polarization of macrophages towards the state in which they will supress the inflammation and promote the resolution of ARDS- so called "alternatively activated macrophages" or M2 macrophages.
The mechanistic data from this study will bring development of new therapy on the MSC basis closer to the patients. Additionally, it will broaden the existing knowledge of lung macrophage biology and their role in the resolution of ARDS which could lead to other new treatments. Importantly, findings from the proposed study may also have relevance for other macrophage dependent inflammatory conditions.

Technical Summary

Acute Respiratory Distress Syndrome (ARDS) is a major cause of acute respiratory failure in critically ill patients, with no effective treatment. The main characteristic of ARDS is excessive pulmonary inflammation. Lung macrophages play an important role in the pathogenesis and resolution of ARDS by orchestrating immune responses. As shown in several preclinical animal studies Mesenchymal Stem Cells (MSC) have strong protective effect in the ARDS and might constitute novel approach to therapy for this devastating disease. However, to develop a new therapy based on MSC, we need a better understanding of the mechanisms mediating their protective effect. Prior publications and our preliminary data suggest that MSC may have a role in promoting alternative activation of macrophages/monocytes, which play an important role in the resolution of ARDS. In this project we propose to study the mechanistic alterations in lung macrophages, induced by MSC in the clinically relevant in vitro and in vivo models of ARDS. This work is important because it will determine the mechanisms and importance of MSC-macrophage interactions in experimental ARDS which is critical for rationale development of MSC-based therapy for these condition, broaden our knowledge about MSC and macrophage biology and could point to new molecular therapeutic targets, with implications for other conditions with macrophage driven pathophysiology.

Planned Impact

The mortality associated with ARDS remains high, between 30-40%. It is a common condition affecting all age groups with an estimated incidence of 79 per 100, 000 patient years. ARDS has significant resource implications, prolonging intensive care unit (ICU) and hospital stay, and requiring rehabilitation in the community. The cost per ICU bed-day in the UK exceeds £1800 and delivery of critical care to patients with ARDS accounts for a significant proportion of ICU capacity. Only 54% of survivors are able to return to work 12 months after hospital discharge. The high incidence, mortality, long-term consequences and economic costs mean that ARDS is an extremely important problem.

Understanding how MSC regulate macrophage phenotype in ARDS may lead to the development of specific new therapies to reprogram inflammatory cells into a cell population that drives resolution. Hastening the recovery from ARDS would lead to a shorter ICU stay, with attendant reductions in nosocomial infection, and other critical illness complications including neuropathy/myopathy/ delirium. This would have direct short term benefits to the patients themselves, including reduced hospital stay and complications, leading hopefully to a better long term functional outcome, with more patients returning to work. Additionally this would lead to a reduced burden for carers and reduced cost of stay and long term healthcare provision.

Understanding the mechanisms mediating effect of MSC on macrophages in ARDS will lead to identification of other therapeutic targets (independently of MSC), (e.g. SOCS proteins or paracrine factors secreted by MSC with immunomodulatory properties) with the potential for further development as a pharmacological treatment for ARDS.

In addition to this condition, the understanding of mechanisms mediating of MSC-macrophage reprogramminig will open new avenues of research for other diseases mediated by excessive inflammation, both in the lung and in other organs.

With this in mind, this research is likely to impact other researchers both academically and industrially in development of follow-on therapeutics and biomaterials that can exploit these effects. Therefore it is tangible that if successful, this project could lead on to the development of other daughter therapeutics that could not only help patients suffering other inflammatory diseases, but also generate new R & D jobs and revenue for the UK.

Publications

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Abreu SC (2020) Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. in American journal of physiology. Lung cellular and molecular physiology

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Fergie N (2019) Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

 
Title Image from publication was selected for the Front Cover of Stem Cells Journal and acquired by Wellcome Trust image collection 
Description Image obtained by Confocal Microscopy showing mitochondrial transfer from Mesenchymal Stromal Cells to Macrophages via Tunneling Nanotubes This image portrays a true representation of an intricate and stunning mechanism of how one cell can "reach out" and support another's biological role. Furthermore it illustrates the importance of how MSC could potentially alleviate debilitating symptoms of inflammatory conditions which are coupled with underlying bacterial infections. 
Type Of Art Image 
Year Produced 2016 
Impact The image was used for the Front Cover of Stem Cells Journal (Vol 34, Number 8, August 2016) and aquired by Wellcome Trust Image Collection 
URL http://stemcellsjournals.onlinelibrary.wiley.com/hub/issue/10.1002/stem.v34.8/
 
Description ERS travel grant
Amount £600 (GBP)
Organisation British Lung Foundation (BLF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2014 
End 09/2014
 
Description MRC CiC
Amount £75,000 (GBP)
Funding ID CD1516-CIC4 
Organisation Medical Research Council (MRC) 
Department MRC Confidence in Concept Scheme
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2018
 
Description MRC Clinical Research Training fellowship
Amount £232,957 (GBP)
Funding ID MR/R017867/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2018 
End 08/2021
 
Description MRC RMRC
Amount £311,085 (GBP)
Funding ID MR/R025096/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 05/2020
 
Description MRC proximity to discovery scheme industry engagement fund
Amount £10,750 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2015 
End 09/2016
 
Description Queens University Belfast PhD studentship 'Adult Stem Cell regulation of Treg functions in the in vitro model of lung repair'
Amount £50,000 (GBP)
Organisation Queen's University Belfast 
Department School of Medicine, Dentistry and Biomedical Sciences
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 09/2018
 
Description Response mode research grant
Amount £567,000 (GBP)
Funding ID MR/S009426/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2022
 
Description Role of SOCS proteins in MSC modulation of macrophage intracellular signalling
Amount £100,000 (GBP)
Organisation Chinese Scholarship Council 
Sector Charity/Non Profit
Country China
Start 10/2018 
End 09/2021
 
Description Wellcome Trust, HICF "Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST)"
Amount £1,678,673 (GBP)
Funding ID HICF-R10-624 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 03/2020
 
Title Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) 
Description ) ARDS is a common condition affecting over 20,000 people per year in the UK: approximately 6000 will die. ARDS occurs in response to many different illnesses including severe trauma, infection and major surgery, and affects all age groups. In ARDS the lungs becomes leaky, and fill with fluid so it becomes difficult to breathe. Patients are put on "ventilators". There is no known specific drug treatment to treat ARDS that improves outcome. (b) Mesenchymal stromal cells (MSCs) can reduce inflammation, fight infection and improve repair of injured tissue. In experimental models of ARDS MSCs can improve lung function and fight infection. MSCs have been given safely to patients with a range of other diseases. In this proposal we want to test MSCs in patients with ARDS. We will use a highly purified population of MSCs derived from umbilical cords. (c) We will assess safety of MSC administration to patients with ARDS, and whether they improve severity of illness. We will study blood, lung fluid and urine from patients with ARDS to identify how MSCs provide their beneficial effect. This may give important information about how MSCs work which may allow further optimization for future use. 
Type Therapeutic Intervention - Cellular and gene therapies
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact If MSCs were effective in this small clinical trial we would proceed to a large trial across the UK to confirm the effect. A treatment that reduced death and long-term disability from ARDS would have major healthcare impact. 
 
Description 'New voices- New Impact', Queens University Belfast, 2015 Outreach Activity 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The free event organised by Queen's University Belfast, showcased 32 talented women and men in the early stages of their research careers, working on projects that have local and global impact. Each of them are profiled in a new publication, 'The DNA of Innovation, Volume V: New Voices, New Impact' which was launched at the event. The event was attended by general public, politicians, University and school students. Dr Krasnodembskaya was presenting her work funded by MRC UK. That helped to enhance public awareness of research funded by RCUK by demonstration that the this work is not only strategically important in an international context but also have benefits to local society and has an impact on life choices of the local young people.
Year(s) Of Engagement Activity 2015
URL http://www.qub.ac.uk/directorates/ResearchEnterprise/News/NewsArticles/Name,538780,en.html
 
Description American Thoracic Society Conference 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Thomas Morrison (PDRA in Dr Krasnodembskaya group) has presented her findings from MRC funded project 'Mesenchymal Stem Cell (MSC) regulation of pulmonary macrophage populations in Acute Respiratory Distress Syndrome (ARDS)'in the form of an oral presentation at the scientific symposium.The ATS conference is attended by more than 20,000 delegates from all around the world, who meet to discuss the latest developments in the respiratory field across 400 sessions. Presenting at the ATS is an excellent way to disseminate findings from MRC funded research to the clinical practitioners and basic scientists working in the multidisciplinary fields as well as industrial partners as widely as possible. Presentation at that prestigious conference helps to gain international recognition and boost the profile of researcher, institution and funder among the world's leading respiratory experts.
Year(s) Of Engagement Activity 2017
URL https://www.atsjournals.org/doi/book/10.1164/ajrccm-conference.2017
 
Description American Thoracic Society International Conference, 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Megan Jackson (PDRA in Dr Krasnodembskaya group) has presented her findings from MRC funded project 'Mesenchymal Stem Cell (MSC) regulation of pulmonary macrophage populations in Acute Respiratory Distress Syndrome (ARDS)'in the form of presigious poster discussion session.The ATS conference is attended by more than 20,000 delegates from all around the world, who meet to discuss the latest developments in the respiratory field across 400 sessions. Presenting at the ATS is an excellent way to disseminate findings from MRC funded research to the clinical practitioners and basic scientists working in the multidisciplinary fields as well as industrial partners as widely as possible. Presentation at that prestigious conference helps to gain international recognition and boost the profile of researcher, institution and funder among the world's leading respiratory experts.
Year(s) Of Engagement Activity 2016
URL http://www.atsjournals.org/doi/book/10.1164/ajrccm-conference.2016
 
Description British Thoracic Society Winter Meeting, 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Results from MRC funded project were presented at the BTS,2016 in the form of an oral presentation. Presentations was made by Dr Thomas Morrison (former PhD student and currently Postdoc in Dr krasnodembskaya group) . British Thoracic Society Meeting remains the highlight of the professional calendar for those working in the field of respiratory medicine and provides a tremendous networking opportunity and in particular, the chance to interact with clinicians, allied health professionals and scientific colleagues from within the UK and abroad in the spoken and poster abstract sessions.
Year(s) Of Engagement Activity 2016
URL https://www.brit-thoracic.org.uk/bts-learning-hub/bts-summer-and-winter-meetings/winter-meeting-2016...
 
Description British Thoracic Society Winter meeting, London,2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Results from MRC funded project were prsented at the BTS,2015 in the form of two oral presentations. Presentations were made by Thomas Morrison (3rd year PhD student in Krasnodembskaya's group) and Dr Megan Jackson (PDRA in Krasnodembskaya's group). British Thoracic Society Meeting remains the highlight of the professional calendar for those working in the field of respiratory medicine and provides a tremendous networking opportunity and in particular, the chance to interact with clinicians, allied health professionals and scientific colleagues from within the UK and abroad in the spoken and poster abstract sessions.
Year(s) Of Engagement Activity 2015
URL https://www.brit-thoracic.org.uk/bts-learning-hub/bts-summer-and-winter-meetings/winter-meeting-2015...
 
Description Delivery of exogenous functional mitochondria to damaged cells (American Thoracic Society International meeting 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Anna krasnodembskaya was invited to give a talk at the plenary scientific session at the American Thoracic Society International conference, in San-Diego, California, USA, 2018..The ATS conference is attended by more than 20,000 delegates from all around the world, who meet to discuss the latest developments in the respiratory field across 400 sessions. Presenting at the ATS is an excellent way to disseminate findings from MRC funded research to the clinical practitioners and basic scientists working in the multidisciplinary fields as well as industrial partners as widely as possible. Presentation at that prestigious conference helps to gain international recognition and boost the profile of researcher, institution and funder among the world's leading respiratory experts.
Year(s) Of Engagement Activity 2018
 
Description ERS Lung Science Conference 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The ERS Lung Science Conference is at the forefront of basic and translational respiratory science and it is an essential event for budding respiratory researchers looking to boost their career. It offers a unique opportunity to network with peers from across the globe and will present cutting-edge abstracts on novel experimental lung research.
Yue Su, 2nd year PhD student presented a poster on the role of miRNA transfer in MSC extracellular vesicles.
Year(s) Of Engagement Activity 2020
 
Description ERS Lung Science Conference 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Anna Krasnodembskaya was elected to serve on the Organisation Committee for ERS LSC 2020 (metabolic alterations in Lung aging and Disease) and also was invited to give a talk at the scientific session 'Therapeutic targeting of metabolic alterations in lung diseases', her talk was entitled 'Metabolic reprogramming by mesenchymal stem cells as a strategy for lung repair'. Eropean Respiratory Society LSC is a flagship ERS eventand is at the forefront of basic and translational respiratory science and it is an essential event for budding respiratory researchers looking to boost their career. It offers a unique opportunity to network with peers from across the globe and will present cutting-edge abstracts on novel experimental lung research.
Year(s) Of Engagement Activity 2020
URL https://www.ersnet.org/congress-and-events/metabolic-alterations-in-lung-ageing-and-disease
 
Description European Respiratory Society International Congress, Munich, 2014 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Krasnodembskaya has given an oral presentation "Human Mesenchymal Stromal Cells (MSC) modulate pulmonary macrophage polarization in vivo and in vitro" based on findings from MRC funded project 'Mesenchymal Stem Cell (MSC) regulation of pulmonary macrophage populations in Acute Respiratory Distress Syndrome (ARDS)'.The ERS International Congress is attended by more than 20,000 delegates from all around the world, who meet to discuss the latest developments in the respiratory field across 400 sessions. Presenting at the Congress is an excellent way to disseminate findings from MRC funded research to the clinical practitioners and basic scientists working in the multidisciplinary fields as well as industrial partners as widely as possible. Presentation at that prestigious congress helps to gain international recognition and boost the profile of researcher, institution and funder among the world's leading respiratory experts. Participation in ERS allowed broad networking opportunities with the potential to develop new international collaborations, as a result an agreement on collaboration was achieved with Prof Daniel Weiss ,University of Vermont,USA. Prof Weiss is a leading expert in lung regeneration and bioengineering, we agreed to collaborate on the project focused on understanding the role of immune system in lung regeneration.
Year(s) Of Engagement Activity 2014
URL http://erscongress.org/home-2014
 
Description European Respiratory Society International Congress 2014 Press Conference 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Dr Anna Krasnodembskaya gave a press conference at the ERS,2014 in Munich on the results from MRC-funded project.

ERS Congress 2014 Press Release: "study sheds light on how stem cells can be used to treat lung disease"

This press conference was attended by about 20 journalists, representing different media (newspapers, magazines, websites). Reports highlighting Dr Krasnodembskaya research were published on several resources. Thus, the results from the study were disseminated to the very broad international audience helping to promote understanding of potential for mesenchymal stem cell based therapy for lung diseases
Year(s) Of Engagement Activity 2014
URL http://www.erscongress.org/media-centre/press-releases/47-press-releases/219-study-sheds-light-on-ho...
 
Description European Respiratory Society International Congress, 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Megan Jackson (PDRA in Dr Krasnodembskaya group) has presented her findings from MRC funded project 'Mesenchymal Stem Cell (MSC) regulation of pulmonary macrophage populations in Acute Respiratory Distress Syndrome (ARDS)'in the form of a poster.The ERS International Congress is attended by more than 20,000 delegates from all around the world, who meet to discuss the latest developments in the respiratory field across 400 sessions. Presenting at the Congress is an excellent way to disseminate findings from MRC funded research to the clinical practitioners and basic scientists working in the multidisciplinary fields as well as industrial partners as widely as possible. Presentation at that prestigious congress helps to gain international recognition and boost the profile of researcher, institution and funder among the world's leading respiratory experts.
Year(s) Of Engagement Activity 2016
URL https://erscongress.org/programme-2016.html
 
Description European Respiratory Society annual Congress 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ERS annual congress is the once-a-year occasion when the world's respiratory experts meet, to present and discuss the latest scientific and clinical advances across the entire field of respiratory medicine. It has a really outstanding programme and is now the largest respiratory meeting in the world.
PhD student Yue Su has presented a poster on the work funded by MRC focussed on how miRNA transferred in the MSC extracellular vesicles modulate macrophages in ARDS
Year(s) Of Engagement Activity 2020
URL https://www.ers-education.org/events/international-congress/virtual-2020
 
Description International Society for Respiratory Diseases (China) & American Thoracic Society Congress 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Anna Krasnodembskaya was invited to speak at the joint Internatinal Society for Respiratory Diseases (China) & American Thoracic Society Congress in Shanghai, China. This Congress features joint sessions organised by Respiratory Societies from China and USA. World leading respiratory scientists are invited to present their latest findings in areas of diagnostics, treatmnts and emerging new topics in respiratory medicine. There were more than 2000 delegates from China and internationally. This congress provided a great oportuity to exchange ideas with Chinese colleagues and establish new collaborations.
Year(s) Of Engagement Activity 2019
URL https://www.medmeeting.org/MiniSiteEn/Content/110577?type=1
 
Description MSC nanotubules as a cell-to cell communication system in Acute Respiratory Distress Syndrome (International Society for Cell and Gene Therapy International Meeting, 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Anna Krasnodembskaya was invited to give a talk at the plenary session (preconference MSC workshop) at the International Society for Cell and Gene Therapy International meeting in Montreal, Canada, in 2018. This invitation-only conference brought together more than 2000 leading researchers and bio-industries working in the field og cell and gene therapy from around the globe. Sessions featured innovative research in mesenchymal stem cell (MSC) biology, endogenous lung progenitor cells, embryonic stem cells and reprogrammed pluripotent stem cells, tissue engineering strategies and cell-based therapies In addition to internationally recognized leaders in the field junior investigators also presented at the meeting. That is an excellent opportunity to disseminate the findings from MRC-funded work to the world leading experts in the field, receive constructive feedback, generate new ideas and stay up-to date with the latest advancements in cell therapies for lung diseases.
Year(s) Of Engagement Activity 2018
URL https://www.celltherapysociety.org/events/EventDetails.aspx?id=1005851
 
Description Northern Ireland Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact NI science festival comprise the range of workshops, talks and interactive activities for young people, parents and schools. Best scientists from NI and beyond discuss their work, cutting-edge research and what the future might hold. Dr Krasnodembskaya and her group (2 Postdocs and a PhD student) showcased their research at the the Centre for Experimental Medicine event 'Know Your Enemy' aimed to provide first-hand insights into disease focused research, with demonstrations of basic laboratory experiments, patient-based research and clinical trials. More than 300 people in the age range from 1 to 90 attended these two events.The feedback has been incredibly positive and visitors were very impressed. Impact of such activity is in promoting education and understanding the importance of research in general public as well as influence on the young people's career choices
Year(s) Of Engagement Activity 2019
 
Description Northern Ireland Science Festival 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact NI science festival comprise the range of workshops, talks and interactive activities for young people, parents and schools. Best scientists from NI and beyond discuss their work, cutting-edge research and what the future might hold. Dr Krasnodembskaya and her group (2 Postdocs and a PhD student) showcased their research at the the Centre for Experimental Medicine event 'Know Your Enemy' aimed to provide first-hand insights into disease focused research, with demonstrations of basic laboratory experiments, patient-based research and clinical trials. More than 300 people in the age range from 1 to 90 attended these two events.The feedback has been incredibly positive and visitors were very impressed. Impact of such activity is in promoting education and understanding the importance of research in general public as well as influence on the young people's career choices
Year(s) Of Engagement Activity 2020
URL https://www.nisciencefestival.com/
 
Description Northern Ireland Science Festival, 'Celebrating Science at Queens' & 'Know Your Enemy' events 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact NI science festival comprise the range of workshops, talks and interactive activities for young people, parents and schools. Best scientists from NI and beyond discuss their work, cutting-edge research and what the future might hold. Dr Krasnodembskaya was invited to showcase her research at two events: 'Celebrating Science at Queens' - the opening event of the Festival and showcase event at the Centre for Experimental Medicine 'Know Your Enemy' aimed to provide first-hand insights into disease focused research, with demonstrations of basic laboratory experiments, patient-based research and clinical trials. More than 500 people in the age range from 1 to 90 attended these two events.The feedback has been incredibly positive and visitors were very impressed. Impact of such activity is in promoting education and understanding the importance of research in general public as well as influence on the young people's career choices
Year(s) Of Engagement Activity 2016
URL http://www.nisciencefestival.com/about.php;
 
Description Northern Ireland Sciense Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact NI science festival comprise the range of workshops, talks and interactive activities for young people, parents and schools. Best scientists from NI and beyond discuss their work, cutting-edge research and what the future might hold. Dr Krasnodembskaya and her group (2 Postdocs and a PhD student) showcased their research at the the Centre for Experimental Medicine event 'Know Your Enemy' aimed to provide first-hand insights into disease focused research, with demonstrations of basic laboratory experiments, patient-based research and clinical trials. More than 300 people in the age range from 1 to 90 attended these two events.The feedback has been incredibly positive and visitors were very impressed. Impact of such activity is in promoting education and understanding the importance of research in general public as well as influence on the young people's career choices
Year(s) Of Engagement Activity 2017
 
Description Regenerative Medicine Research Groups (REMERGE) Research Symposium, Belfast, UK, 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Anna Krasnodembskaya was invited to give a talk at the annual Regenerative Medicine Research Groups (REMERGE) Research Symposium. REMERGE is an informal group bringing together PIs from the different schools of Queen's University (as well as industrial collaborators) who's research programs are focused on the regeneration and repair mechanisms. Day-long REMERGE annual symposium brings together international experts in the field and showcase work from Queen's researchers to the broad audience of fellow scientists, postgraduate and undergraduate students and professionals from biotech companies.
Year(s) Of Engagement Activity 2015
 
Description Stem Cells, Cell Therapies and Bioengineering in lung Biology and Lung Diseases, University of Vermont, USA, 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Results from MRC-funded project were presented in the form of two posters (by Thomas Morrison, PhD student and Dr Megan Jackson, PDRA) at the prestigious biannual international workshop Stem Cells, Cellular Therapies, and Bioengineering in Lung Biology and Lung Diseases, hosted by University of Vermont, USA. This invitation-only conference brought together more than 150 leading lung disease researchers from around the globe. Leaders in stem cell biology and regenerative medicine gathered at UVM for four days. Sessions featured innovative research in mesenchymal stem cell (MSC) biology, endogenous lung progenitor cells, embryonic stem cells and reprogrammed pluripotent stem cells, tissue engineering strategies and cell-based therapies In addition to internationally recognized leaders in the field junior investigators also presented at the meeting. That is an excellent opportunity to disseminate the findings from MRC-funded work to the world leading experts in the field, receive constructive feedback, generate new ideas and stay up-to date with the latest advancements in cell therapies for lung diseases.
Year(s) Of Engagement Activity 2015
URL https://www.uvm.edu/medicine/cme/?Page=2015Stem_Cell.html
 
Description Stem Cells, Cellular Therapies, and Bioengineering in Lung Biology and Lung Diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Thomas Morrison' abstract , (PDRA in Krasnodembskaya's group) was selected as the best abstract from Young Investigator 2017 and awarded travel award to present his work at the prestigious biannual international workshop Stem Cells, Cellular Therapies, and Bioengineering in Lung Biology and Lung Diseases, hosted by University of Vermont, USA. This invitation-only conference brought together more than 150 leading lung disease researchers from around the globe. Leaders in stem cell biology and regenerative medicine gathered at UVM for four days. Sessions featured innovative research in mesenchymal stem cell (MSC) biology, endogenous lung progenitor cells, embryonic stem cells and reprogrammed pluripotent stem cells, tissue engineering strategies and cell-based therapies In addition to internationally recognized leaders in the field junior investigators also presented at the meeting. That is an excellent opportunity to disseminate the findings from MRC-funded work to the world leading experts in the field, receive constructive feedback, generate new ideas and stay up-to date with the latest advancements in cell therapies for lung diseases.
Year(s) Of Engagement Activity 2017