UK Dementias Platform

Lead Research Organisation: Cardiff University
Department Name: School of Medicine

Abstract

The UK Dementias Platform (UKDP) is a radically new approach to dementias research, bringing together data from around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of slowing it down. The platform has been funded to the level of £4.5M and invited to apply for a further £7.5M.

To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.

We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.

There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.

There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.

To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.

Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.

Technical Summary

The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and cost-effective translation pipeline from basic discovery through to early phase trials (Fig 1). By combining the analytic and statistical power of >20 clinical and population cohorts representing 2M participants and creating a large readiness cohort, UKDP will create an optimal environment for basic discovery activities relevant to the clinical progression and human impact of dementia. Although UKDP is intended as a strategic and sustainable resource generating increasing scientific benefit over time, it will also deliver short and medium term benefits through the analysis of existing data, the enrichment of strategically selected cohorts, developing new ways of working with industry, and generating interest and further funding for dementias research generally.

A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.

Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.

Planned Impact

The platform will use several vehicles to deliver impact.

These were described in stage 1.

In summary:

For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.

For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.

We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.

Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.

In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.

Publications

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Ahmad S (2018) Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study. in Alzheimer's & dementia : the journal of the Alzheimer's Association

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Andreotti F (2018) Multichannel Sleep Stage Classification and Transfer Learning using Convolutional Neural Networks. in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

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Appleton JP (2017) Hypercholesterolaemia and vascular dementia. in Clinical science (London, England : 1979)

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Arba F (2018) Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack. in International journal of stroke : official journal of the International Stroke Society

 
Description ABN clinical research and academic committee, London representative
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Advisor WHO (World Health Organisation)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact N/A
 
Description Alzheimer Association Educational Workshop: The basics of fluid biomarkers in AD - speaker
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Attend technical meeting on the Implementation of the Global Action Plan on Public Health Response to Dementia
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Canadian Consortium on Neurodegeneration in Aging (CCNA)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Dementia Programme Board - oversee the implementation of the PM's Challenge on Dementia to 2020
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Deputy Chair, ABN Cognitive Disorders Advisory Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact N/A
 
Description German Centre for Neurodegenerative Diseases (DZNE) scientific review
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description JPND SAB Meeting - re-launching its Strategic Research and Innovation Agenda (SRIA)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Member of Prime Minister's Research Champions Group attending G7/G8 summit
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
Impact N/A
 
Description Member, Biobank access committee, Brains for Dementia Research
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description PCA criteria 2013-2015
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.alzforum.org/news/conference-coverage/researchers-join-draw-posterior-cortical-atrophy-ou...
 
Description Press conference
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description UCL ageing event - cultivating research connections across the university: organising committee and plenary speaker
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description UK representative - European Academy of Neurology Dementia Panel
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Vice Chair and Chair Elect, Advisory Council US Alzheimer's Association ISTAART
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description WHO's Global Dementia Observatory discuss the implementation of the global action plan on public health response to dementia 2017-2025
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Work group to establish a Danish brain research centre - Lundbeckfonden, The Brain Prize
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description World Dementia Council
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description 1946 ARUK
Amount £1,824,093 (GBP)
Funding ID ARUK-PG2014-1946 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 06/2017
 
Description ABN Research Fellowship (Cope)
Amount £180,000 (GBP)
Funding ID RG78594 
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2015 
End 11/2018
 
Description ARUK ODDI collaboration: Phenotypic drug discovery in Parkinson's
Amount £200,000 (GBP)
Organisation University of Oxford 
Department Alzheimer's Research UK Oxford Drug Discovery Institute
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2020
 
Description Additional funding from Janssen for Synaptic Plasticity work
Amount £400,000 (GBP)
Organisation Johnson & Johnson 
Department Janssen Pharmaceuticals
Sector Private
Country United States
Start 12/2016 
End 12/2017
 
Description Alcohol misuse: electronic longitudinal alcohol study in communities
Amount £1,200,000 (GBP)
Funding ID ES/L015471/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start  
 
Description Brain Research Trust
Amount £219,355 (GBP)
Organisation Brain Research Trust (BRT) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description Computational Tools for Parkinson's disease Therapeutics
Amount £20,000 (GBP)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2018 
End 01/2019
 
Description Computer Simulation of LRRK2 and GBA interactions
Amount $225,000 (USD)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2019 
End 06/2020
 
Description Drake Foundation: Effects of head injury the NSHD 1946 birth cohort.
Amount £60,852 (GBP)
Organisation The Drake Foundation 
Sector Charity/Non Profit
Country Unknown
Start 04/2017 
End 04/2019
 
Description Drake Foundation: Head Injury, cognition and imaging correlates of dementia in the Insight 46 cohort
Amount £60,852 (GBP)
Organisation The Drake Foundation 
Sector Charity/Non Profit
Country Unknown
Start 04/2016 
End 04/2019
 
Description EU IMI-2. Amyloid imaging to prevent Alzheimer's disease (AMYPAD)
Amount £934,500 (GBP)
Organisation European Social Survey: European Research Infrastructure Consortium (ESS ERIC) 
Sector Charity/Non Profit
Country European Union (EU)
Start 10/2016 
End 09/2021
 
Description Improving prevention trials in AD through imaging
Amount £249,965 (GBP)
Funding ID 261 (AS-PG-15-025) 
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 02/2017
 
Description Investigation of T cell reactivity to alpha-synuclein in Parkinson's disease.
Amount £620,000 (GBP)
Organisation Celgene 
Sector Private
Country United States
Start 10/2018 
End 09/2021
 
Description JPND
Amount £350,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2016 
End 05/2019
 
Description MJ Fox Therapeutic Pipeline Program: Enhancing autophagy flux in Parkinson's disease
Amount $330,000 (USD)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start  
 
Description MRC Deep and Frequent Phenotyping Grant (Simon Lovestone PI, awarded 2016)
Amount £6,900,000 (GBP)
Funding ID MR/N029941/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Momentum Award (Microglial interactions in Alzheimer's Disease)
Amount £4,300,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
 
Description MRC Momentum Award (Microglial interactions in Alzheimer's Disease-informatics)
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Partnership Award (Dementias Platform UK Stem Cell Partnership)
Amount £1,200,000 (GBP)
Funding ID MR/N013255/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2016 
End 06/2020
 
Description Mental Health Pathfinder Award
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description NTAD: new-therapeutics-in-alzheimers-disease
Amount £1,200,000 (GBP)
Organisation MRC Dementias Platform UK 
Sector Public
Country United Kingdom
Start 06/2018 
End 09/2020
 
Description New Therapeutics in Alzheimer s Disease (NTAD) - ARUK
Amount £100,000 (GBP)
Funding ID RG89702 
Organisation Versus Arthritis 
Start 10/2017 
End 08/2020
 
Description Ordering the earliest neuronal response events
Amount $150,000 (USD)
Funding ID 16324 
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2019 
End 01/2020
 
Description Oxford Interdisciplinary Bioscience Doctoral Training Partnership (DTP) - Sally Cowley
Amount £90,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2023
 
Description Oxford Parkinson's Disease Centre Discovery Cohort PBMCs for T cell reactivity study
Amount £78,528 (GBP)
Organisation Celgene 
Sector Private
Country United States
Start 09/2018 
End 09/2019
 
Description ROADS IMI2 call 6
Amount € 4,000,000 (EUR)
Organisation European Commission 
Department Innovative Medicines Initiative (IMI)
Sector Multiple
Country European Union (EU)
Start 09/2016 
End 08/2018
 
Description Sanofi/Genzyme: Modulating GBA activity as a Parkinson's disease therapy
Amount £200,000 (GBP)
Organisation Sanofi 
Department Genzyme Therapeutics Ltd
Sector Private
Country United Kingdom
Start 11/2016 
End 10/2017
 
Description The Airwave Health Monitoring Study (AHMS). An Occupational Cohort Study of the British Police Forces
Amount £1,941,097 (GBP)
Funding ID MR/R023484/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2018 
End 04/2023
 
Description The development of digital biomarkers for dementia
Amount £1,200,873 (GBP)
Organisation Eli Lilly & Company Ltd 
Sector Private
Country United Kingdom
Start 12/2016 
End 11/2022
 
Description UK Dementias Platform
Amount £13,607,814 (GBP)
Funding ID MR/L023784/2 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 06/2019
 
Description Uniting iPCS and CRISPR/Cas9 screens- a platform to model and interrogate genetic disease in Oxford
Amount £80,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 09/2019
 
Description Wellcome Trust Clinical Training Fellowship
Amount £174,791 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description What makes strategic stroke strategic? Multimodal imaging and network methods to predict dementia after strategic stroke
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 08/2017
 
Title CRISPR gene editing 
Description We have been able to establish CRISPR/Cas9 gene editing in our lab as a result of this project 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact We have been able to perform gene editing in iPSC lines. 
 
Title Cognitive test battery implemented in UK Biobank 
Description DPUK has developed a cognitive test battery suitable for use in large-scale population studies. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact The battery has been deployed in the UK Biobank study 
 
Title DPUK data portal 
Description The DPUK secure data analysis platform for dementia research brings together over 30 UK cohorts (n=2M) for data sharing. This is a step-change in UK data sharing capacity 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact By bringing the researcher to the data , the DPUK data portal reduces the transaction costs of data sharing at many levels. The concept has proven attractive to researchers form France, Netherlands, China, Japan, South Korea, Canada and the US and discussions are underway with these colleague to include their data within the portal. 
URL http://www.dementiasplatform.uk/
 
Title Dopamine neuron microfluidics 
Description Development of stem cell-derived neuronal culture techniques using microfluidic devices to channel axonal growth. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact Not yet: it is ongoing development 
 
Title High content, high throughput analysis 
Description The ability to perform detailed high-throughput analysis of neurons in culture 
Type Of Material Technology assay or reagent 
Year Produced 2016 
Provided To Others? Yes  
Impact Shared use of best practice in high-throughput analysis using Opera Phenix imager and high-throughout plate readers 
 
Title Imaging network protocols 
Description The DPUK molecular and structural imaging network has been awarded a MRC partnership grant and an ARUK project grant t develop standardised image acquisition and pre-processing protocols for brain imaging. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact TO BE CONFIRMED 
 
Title In vitro electrophysiology 
Description Patch-clamp techniques to measure neuronal activity of stem cell-derived neurons 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Analaysis of stem cell-derived neurons: dopamine neurons, cortical neurons, motor neurons and medium spiny neurons 
 
Title Live cell imaging techniques in iPS-derived DA neurons in vitro 
Description We have optimised a live cell imaging protocol for the visualisation and measurement of mitochondrial membrane potential in differentiated neurons. 
Type Of Material Cell line 
Provided To Others? No  
Impact The membrane potential-sensing dye TMRM can be used to quantify membrane potential, with increased fluorescence indicating increased membrane potential. 
 
Title Microglia differentiation 
Description The ability to generate microglia from human stem cells from dementia patients 
Type Of Material Cell line 
Provided To Others? No  
Impact We will be able to compare the function of microglia generated from patients and from controls 
 
Title PLA in stem cell neurons 
Description To enable the detection of a-syn oligomers in stem cell-derived dopamine neurons 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The detection of a-syn oligomers in stem cell-derived dopamine neurons 
 
Title RNA-Seq 
Description Development of methods for analysis of RNA-Seq 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Understanding of gene expression profiles in selected cell population 
 
Title Stem cell network protocols 
Description The DPUK stem cell network has been awarded a MRC partnership grant to establish network activity including the development of standard protocols for developing specific tissue types relevant to dementia research. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact TO BE CONFIRMED 
 
Title Target discovery assays 
Description Develop target discovery assays using high throughput screens 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact New research facilty built for our work 
 
Title WP13 Agreed Standards for Collection, Classification & Storage of Brain Tissue 
Description This report relates to Dementias Platform UK (DPUK) Objective 3 of Work Package 13: Brain Donation. Specifically, objective 3 is to develop agreed standards for the collection, classification and storage of brains tissue. Harmonisation of procedures across brain banks enables i) comparable standards of quality and diagnostic categorisation to be employed, ii) implementation of comparable sampling, preparation and storage techniques and iii) provision of consistent key tissue quality and pathology data. Consistent with the diversity of researcher requests, it is also necessary to preserve a sufficient degree of operational flexibility in accordance with the nature of the disease and user demand. In such instances, a rationale and explanation of any differences can be provided, or where appropriate, a view presented as to when convergence might be achieved in the future. The policies outlined below are those agreed by the 4 Medical Research Council (MRC) funded brain banks as part of a milestoned funding package and are used as a minimum protocol by all the banks in the MRC UK Brain Bank Network (UK BBN). Minimal standards for collection are presented in relation to i) Brain tissue, ii) Clinical and Neuropathological information and iii) Neuropathology (Classification & storage). 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact pending DPUK consensus meeting on brain donation strategy 
 
Title WP13 Brain donation UK Brain Bank capacity and strategy for UK brain donation 
Description 1. This report relates to DPUK Work Package 13 Objective 7: To establish a brain banking strategy based on capacity and scientific value. 2. The report presents quantitative and descriptive data relating to the current capacity and workload of 10 UK brain banks, evaluates options for extending brain donation to DPUK cohorts and makes recommendations for a longer term brain donation strategy. 3. Currently there is little spare capacity available across the UK Brain Bank Network. 4. Across the brain banks there are significant differences in the proportion of ad hoc vs registered brains collected. 5. Estimates of the number and characteristics of participants to be consented to brain donation through DPUK are required in order to predict the impact of DPUK with greater precision. 6. The availability of mortuary services is a potential bottleneck & there is a need to engage with NHS Trusts. 7. Clarification of scientific questions and identification of what DPUK seek to learn from donated brains would help to shape a brain donation strategy. 8. Conditional support for a UK Biobank brain donation pilot study. 9. A decentralised model based upon the accommodation of extra DPUK activity within existing brain bank infrastructure across the 10 brain banks is favoured. 10. The long term suitability of alternative models for consenting, centralised collection and storage warrant exploration. 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact Basis for consensus meeting on new approaches to UK brain banking. To inform a pilot study using UK Biobank and the Manchester Brain Bank. Presentation of alternative models for consenting, registration, coordination of participants and collection, processing, storage and retrieval of brain samples 
 
Title WP13 Brain donation: Sample access plan. 
Description A briefing document on access to post-mortem samples and data from the proposed DPUK collection From the discussion above decisions concerning access to DPUK samples and data need to be taken at an early stage. A number of key factors determine the framework for granting access to tissue samples, accompanying neuropathological and clinical data through a DPUK platform. These factors relate to custodianship, ethical approval, eligibility for access, the application process and the conditions of access. Following specific DPUK guidance in relation to each of these factors, subsequent actions in defining a sample access plan include the development of 1) a standard operating procedure, 2) principles of access, 3) a common request application form, 4) an application process and 5) conditions of access. While a dual approach to access implies that established brain bank and cohorts procedures will cover many aspects of the request process, the section below highlights those elements requiring unique consideration in relation to DPUK generated applications. It will be particularly important to establish a researcher FAQs to guide applicants though the process and help requesters to determine suitability of data and eligibility to gain access. 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact pending DPUK consensus meeting on brain donation strategy 
 
Title Alzhemer's Disease Polygenic Risk Profiling 
Description This model used data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained from the International Genomics of Alzheimer's Project (IGAP). Alzheimer's disease (AD) Polygenic risk scores were generated for 3177 cases and 7277 controls (GERAD data) and tested whether the alleles identified to associate with disease in IGAP sample are significantly enriched in the cases relative to the controls in the GERAD sample. The disease prediction accuracy was investigated in a sample of 3049 cases and 1554 controls (for whom APOE genotype data was available) by means of sensitivity, specificity, area under the receiver operating characteristic curve (AUC) and positive and negative predictive values. The best prediction accuracy AUC = 78.2% (95% confidence interval 77-80%) was achieved by a logistic regression model with APOE, the polygenic score, sex and age as predictors. 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? Yes  
Impact This approach is used to create SNP arrays for AD prediction (for research only so far). 
 
Title DPUK cohorts database 
Description collection of >30 UK cohorts available for cross-cohort analyses 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The bringing together of data from >30 cohorts is transformative in delivering greater data access to the research community 
URL http://www.dementiasplatform.uk/
 
Title iPSC resource for researchers 
Description iPSC resources available are listed on DPUK website where they can download iPSC directory provides the opportunity for researchers to formally request over 100 stem cell lines derived from healthy and diseased individuals 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Valuable way for researchers to find out about available resource 
URL https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso...
 
Description AMYPAD 
Organisation Amyloid Imaging to Prevent Alzheimer's Disease
Country European Union (EU) 
Sector Public 
PI Contribution JMS is UCL lead for AMYPAD at UCL - which has interdependencies with DPUK through EPAD
Collaborator Contribution Design of protocols
Impact Project recently commenced
Start Year 2016
 
Description Abeta functional assays 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution We have worked to develop improved in vitro analysis odf Abeta function
Collaborator Contribution Collaborative development of assay
Impact Ongoing collaboration
Start Year 2015
 
Description Collaboration with Eisai AiM Institute 
Organisation Eisai Inc
PI Contribution Consultancy on Polygenic risk score for clinical trials
Collaborator Contribution We are in the process of negotiations
Impact potentially this collaboration will pay for a time of a postdoctoral researcher
Start Year 2018
 
Description Collaboratiuon with European Bioinformatics institute 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution We plan to provide a software for polygenic risk score calculation and prosess the GWAS summary statistics for all current GWASes available in EBI GWAS catalogue
Collaborator Contribution provide data access to the GWAS catalogue
Impact This collaboration will provide the GWAS processed data to the research community for quick and efficient calculation of polygenic risk score for any disorder (stored in the EBI GWAS catalogue)
Start Year 2019
 
Description DPUK Analysts Expert Community 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK.
Collaborator Contribution Expertise to the discussion of analytical projects to focus on for DPUK for the future.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Analysts Expert Community 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK.
Collaborator Contribution Expertise to the discussion of analytical projects to focus on for DPUK for the future.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Analysts Expert Community 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK.
Collaborator Contribution Expertise to the discussion of analytical projects to focus on for DPUK for the future.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Analysts Expert Community 
Organisation University of Cambridge
Department MRC Biostatistics Unit
Country United Kingdom 
Sector Public 
PI Contribution Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK.
Collaborator Contribution Expertise to the discussion of analytical projects to focus on for DPUK for the future.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Analysts Expert Community 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK.
Collaborator Contribution Expertise to the discussion of analytical projects to focus on for DPUK for the future.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Analysts Expert Community 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK.
Collaborator Contribution Expertise to the discussion of analytical projects to focus on for DPUK for the future.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Optimisation of high-content imaging protocols with Opera Phenix imager
Collaborator Contribution The ARUK Stem Cell Research Centre, Cambridge has standardised the use of the Opera Phenix and Nanostring Sprint instruments for QC in iPSC reprogramming and cproduction of cortical neurons. The Phenix is used for high-throughput imaging of pluripotency markers in patient-derived lines that are generated at the centre. The lab has established a method for routine characterisation of cortical neuron productions using the Nanostring digital gene expression platform. This will facilitate harmonisation of protocols between DPUK centres, and within the STEMBANCC consortium. The imaging platform has been used to develop methods for production of human microglia from iPSCs, and to study cell biology in patient iPSC-derived microglia, focussing on TREM2 mutatiosn. In collaboration with Talisman Therapeutics and AstraZeneca, assays have been established to measure protein uptake in cortical neurons by live imaging.
Impact Development of a strong Dementia Stem Cell Network in DPUK
Start Year 2016
 
Description DPUK DSCN 
Organisation Cardiff University
Department School of Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University College London
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Cambridge
Department Gurdon Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Public 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Manchester
Department Manchester Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK Data Discovery Tools Categorisation and Coding Programme 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide data from our cohort
Collaborator Contribution Create Data discovery tool
Impact Still ongoing
Start Year 2018
 
Description DPUK Genetics Expert Community 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing infrastructure and contacts with academics in the expertise of Genetics.
Collaborator Contribution Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal.
Impact Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal.
Start Year 2014
 
Description DPUK Imaging Consortium 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Public 
PI Contribution Sharing of Imaging protocols and data management structures
Collaborator Contribution N/A
Impact Project recently commenced
Start Year 2016
 
Description DPUK Ontologies Expert Community 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Facilitating meetings through our administrative support and providing leadership through the scientists on our central team.
Collaborator Contribution Expertise to the development of DPUK ontology discussion.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Ontologies Expert Community 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Facilitating meetings through our administrative support and providing leadership through the scientists on our central team.
Collaborator Contribution Expertise to the development of DPUK ontology discussion.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Ontologies Expert Community 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Facilitating meetings through our administrative support and providing leadership through the scientists on our central team.
Collaborator Contribution Expertise to the development of DPUK ontology discussion.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK Ontologies Expert Community 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Facilitating meetings through our administrative support and providing leadership through the scientists on our central team.
Collaborator Contribution Expertise to the development of DPUK ontology discussion.
Impact Too early for significant outputs or outcomes
Start Year 2018
 
Description DPUK industry partnership 
Organisation Araclon Biotech
Country Spain 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation AstraZeneca
Department AZ Medimmune
Country United Kingdom 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation GlaxoSmithKline (GSK)
Department Neurology and GI Centre of Excellence for Drug Discovery (CEDD) GSK
Country United Kingdom 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation Ixico
Country United Kingdom 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation Janssen Research & Development
Country Global 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation SomaLogic
Country United States 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DSG (Data Study Group) Network 
Organisation Alan Turing Institute
Country Unknown 
Sector Academic/University 
PI Contribution A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts.
Collaborator Contribution Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop
Impact Newly active March 2019
Start Year 2019
 
Description DSG (Data Study Group) Network 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts.
Collaborator Contribution Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop
Impact Newly active March 2019
Start Year 2019
 
Description Dementias Platform UK Stem Cell Partnership 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Public 
PI Contribution OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network
Collaborator Contribution Members will share expertise and stem cell lines as part of DPUK Stem Cell Network
Impact Ongoing
Start Year 2016
 
Description Dementias Platform UK Stem Cell Partnership 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network
Collaborator Contribution Members will share expertise and stem cell lines as part of DPUK Stem Cell Network
Impact Ongoing
Start Year 2016
 
Description Electrophysiology in iPSC neurons 
Organisation University of Oxford
Department Department of Pharmacology
Country United Kingdom 
Sector Academic/University 
PI Contribution We have worked to establish electrophysiology analysis of iPSC-derived cortical neurons
Collaborator Contribution Helped us to establish the technique
Impact Ongoing collaboration
Start Year 2014
 
Description Enhancing autophagy flux in Parkinson's disease 
Organisation AstraZeneca
Department Astra Zeneca
Country United States 
Sector Private 
PI Contribution OPDC test drug like molecules in cellular models of Parkinson's
Collaborator Contribution Astra Zeneca to provide drug-like small molecules.
Impact Ongoing
Start Year 2016
 
Description European Prevention of Alzheimers disease project (EPAD) 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution DPUK is contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study
Collaborator Contribution European colleagues are also contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study
Impact Multi-disciplinary: clinicians, imagers, geneticists, statisticians, epidemiologists.
Start Year 2016
 
Description Insight 46 
Organisation Medical Research Council (MRC)
Department MRC Cognition and Brain Sciences Unit
Country United Kingdom 
Sector Public 
PI Contribution Collaborating with colleagues at the UCL MRC National Survey for Health and Development, Institute of Molecular Neuroscience, and Institute of Nuclear Medicine, Insight 46 is a major prospective two-time point (0, 12m) MRI, amyloid PET, clinical, biomarker and neuropsychological study of 500 members of the MRC National Survey for Health and Development 1946 birth cohort. This highly inter-disciplinary study involving UCL based epidemiologists, neurologists, imagers, clinical chemists, geneticists and statisticians aims to determine the earliest biomarker changes of AD, the contribution of genetic and life course influences on the development of late life cognitive impairment, and the optimal means of designing AD prevention studies. This >£5M project includes funding from ARUK, MRC Dementias Platform UK (WP4), Wolfson Foundation and Brain Research Trust, as well as industry contributions (~£850K, Eli Lilly). As well as coordinating the project (with Fox, Richards) I supervise a study manager, two clinical PhD students (Lane and Parker, a Wellcome Training Fellowship), and a study coordinator. The study is well underway, with >300 scaned; cross-sectional data will complete in October 2017; and longitudinal collection two years later.
Collaborator Contribution N/A
Impact N/A
Start Year 2014
 
Description MINDMAPS 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution MINDMAPS is a DPUK-enabled project - it used our support and infrastructure in order to gain partnership and funding.
Collaborator Contribution The protocols for the MINDMAPS intended to evaluate three novel radioligands that are intended to quantify the regional availability of other radioligands being brought online for GMP production. 3 protocols are in place.This study has been set up as a public-private collaboration and has leveraged substantial new investment, both from the MRC and from other funders.
Impact Too early for significant outputs or outcomes
Start Year 2017
 
Description MRC fellowship 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution advice and training on genomic data analysis
Collaborator Contribution A researcher, Dr. Emma Anderson, who is a highly productive junior researcher
Impact 1. To improve causal inference in mendelian randomization studies of dementia 2. To improve understanding of the genetic risk for dementia and trajectories of cognitive capabilities in aging 3. To identify modifiable risk factors that are related to dementia and cognitive decline
Start Year 2016
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Alzheimer's Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation AstraZeneca
Department Astra Zeneca
Country United States 
Sector Private 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Johnson & Johnson
Department Janssen Pharmaceuticals
Country United States 
Sector Private 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description ODDI Phenotypic drug discovery in Parkinson's 
Organisation University of Oxford
Department Alzheimer's Research UK Oxford Drug Discovery Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Collaborative drug discovery project in Parkinson's
Collaborator Contribution Collaborative drug discovery project in Parkinson's
Impact Ongoing
Start Year 2017
 
Description Synaptic Health 
Organisation Alzheimer's Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation AstraZeneca
Department AZ Medimmune
Country United Kingdom 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Janssen Biotech, Inc.
Country United States 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Public 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) 
Organisation Alan Turing Institute
Country Unknown 
Sector Academic/University 
PI Contribution Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup
Collaborator Contribution Provision of resources at DPUK Datathons
Impact Newly established March 2019
Start Year 2019
 
Description The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup
Collaborator Contribution Provision of resources at DPUK Datathons
Impact Newly established March 2019
Start Year 2019
 
Description Twinning: Centre PD 
Organisation University of Luxembourg
Department Faculty of Science, Technology and Communication
Country Luxembourg 
Sector Academic/University 
PI Contribution OPDC will share information on clinical cohorts, stem cells and neuropathology
Collaborator Contribution Centre PD will share information on clinical cohorts, stem cells and neuropathology Centre PD worked with us on the EU Twinning grant to facilitate OPDC clinical data base move from Open Clinica to Red Cap System
Impact Ongoing
Start Year 2015
 
Description UK Dementia Platform (DPUK) 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Many OPDC members play a leading role in the DPUK. Richard Wade-Martins head the DPUK National Dementia Stem Cell Network, Simon Lovestone heads Informatics component and Clare MacKay leads on informatics analysis of imaging. Richard and Simon are on thr DPUK Executive Committee.
Collaborator Contribution The MRC Dementias Platform UK (DPUK) is a £53M public-private partnership, developed and led by the Medical Research Council, to accelerate progress in, and open up, dementias research. The DPUK's aims are early detection, improved treatment and ultimately, prevention, of dementias.
Impact The DPUK launched in Autumn 2014. It is directed by Dr John Gallacher at the University of Cardiff, together with an executive team of investigators drawn from seven universities (Cambridge, Edinburgh, Imperial College London (ICL), Oxford, Newcastle, University College London (UCL) and Swansea), including the UCL-based MRC Unit for Lifelong Health and Ageing. The clinical research infrastructure award links DPUK with further universities, Manchester and Bristol.
Start Year 2014
 
Title Dementias Platform UK Data Portal 
Description The DPUK Data Portal is a platform to allow the ingress of data from cohort studies and real-world evidence data from across the UK and internationally. The Portal allows access, subject to data provider approval, to said data via an integrated application system, and provides an analysis environment on remote desktop to allow distributed team science from anywhere in the world. The Portal environment comprises of front end user tools, a virtual desktop infrastructure for data analysis, a security system for permissions management and data upload, and an underlying architecture of substantial storage and applications to support the data needs. 
Type Of Technology Webtool/Application 
Year Produced 2017 
Impact To date (early 2019) we have had ~80 applications for cohort data via our new processes. Of these, 50 have been approved and at least 25 studies are underway with analysis of their approved cohort data. All of these studies are contributing to the dementia research community with a mixture of traditional epidemiological hypotheses, methodology validation, complex machine learning, and statistical modelling all being achieved in the Portal. Website: https://portal.dementiasplatform.uk 
 
Title Digital Biomarkers for Dementia 
Description This collaboration aims to produce smartphone and wearable focused, remote, digital biomarkers targeted at the earliest possible preclinical signs of the disease. 
Type Of Technology Webtool/Application 
Year Produced 2017 
Impact The first of the outputs from this research collaboration are currently deployed in the PREVENT and DFP trials. 
 
Title POLARIS 
Description We developed a novel approach to genetic set-based analysis and polygenic risk scoring, which accounts for linkage disequilibrium between SNPs and informs the analysis with previously reported effect sizes of a SNP's association to disease. We call this method POLARIS: POlygenic Linkage disequilibrium-Adjusted RIsk Score. 
Type Of Technology Software 
Year Produced 2017 
Open Source License? Yes  
Impact NA 
URL https://github.com/BakerEA/POLARIS
 
Title UKSeRP (UK Secure eResearch Platform) 
Description UKSeRP is a secure data management and analysis platform created through MRC's capital investment in the Farr Institute. It is an integrated suite of hardware and software tools that enables uses to upload and remotely manage their data and make the data available for analysis to distributed research teams. UKSeRP instances have been created for the MRC Dementias Platform UK, UK Biobank outcome adjudication group, ALSPAC, linked Millennium Cohort Data and the Multiple Sclerosis Register. 
Type Of Technology Webtool/Application 
Year Produced 2014 
Impact UKSeRP supports the development and implementation of distributed multi-disciplinary UK Team Science in providing access to multi-modal multi-cohort data. 
 
Description 26 April 2016, DPUK Annual Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact DPUK Open Day
Year(s) Of Engagement Activity 2016
URL http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Conference-Programme.pdf
 
Description Participation in an activity, workshop or similar - Poster presentation at CTAD conference, Barcelona 24-27th October 2018: Child adversity 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation: Using the power of Dementias Platform UK (DPUK) cohorts to investigate the longitudinal effects of childhood adversity on adult cognition and health outcomes: Implications for cognitive change & dementia outcomes. Interest and discussion in our research and further work which will involve further cohorts and a publication.
Year(s) Of Engagement Activity 2018
URL http://www.ctad-alzheimer.com/
 
Description "The Funny Side of Parkinson's" 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact "The Funny Side of Parkinson's" on BBC1. Paul Mayhew-Archer Documentary.
Richard Wade-Martins and Fahd Baig appeared to talk about OPDC.
Paul was named best presenter at the Grierson Awards for this documentary.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/iplayer/episode/b072xkcz/inside-out-south-parkinsons-the-funny-side
 
Description #DementiaActionWeek2018 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sharing content to promote #DementiaActionWeek2018 including producing original video of researcher
Year(s) Of Engagement Activity 2018
URL https://twitter.com/WadeMartinsLab/status/999632001920651264
 
Description 1946 70th birthday event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The 70th Birthday Event celebrated the 70th birthday of participants in the MRC NSHD (1946 birth cohort) - we provided a display of brain imaging
Year(s) Of Engagement Activity 2016
 
Description 2018 article published on iPS research in Oxford in Phenotype (Oxford Biochemical society magazine) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A decade of IPS cell research in Oxford by Sally Cowley
Phenotype is the magazine of the Oxford University Biochemical Society. It is run by students and staff and published on a termly basis.
Year(s) Of Engagement Activity 2018
URL https://issuu.com/phenotypejournal/docs/mt18
 
Description 2018/19 OPDC Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We produced a newsletter on OPDC activities.
This was sent to all study participants, those on OPDC news mailing list and will be handed out at events.
Year(s) Of Engagement Activity 2018,2019
URL https://www.opdc.ox.ac.uk/_asset/file/opdc2018-19-newsletter.pdf
 
Description 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal.
Year(s) Of Engagement Activity 2015
 
Description 5-7 October 2016, CCNA ISAB (Vancouver)(premanifest disease & cognitive footprint?) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary lecture at Canadian consortium on Neurodegeneration and aging
Year(s) Of Engagement Activity 2016
 
Description 6-7 April 2016, DZNE (Bonn)"The role of genetic cohorts in bridging clinical and basic science" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussion of the role of Genetic cohorts to advise the German Neurodegenerative disease research network
Year(s) Of Engagement Activity 2016
 
Description A moving target? Dementia in changing older populations (and a changing world) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A talk was given at AAIC 2016 (Alzheimer's Association International Conference) 23-28 July in Toronto, Canada.
Year(s) Of Engagement Activity 2016
 
Description A population perspective on dementia and its relationship with ageing and dying across time 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited speaker at Brocher foundation, Geneva, 14-15 April 2016. The redefinition of Alzheimer's disease and its social and ethical consequences.
Year(s) Of Engagement Activity 2016
 
Description ARUK Manchester Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The Alzheimer's Research UK Conference is the UK's largest dementia research conference and this year Alzheimer's Research UK hope to host up to 450 delegates in the Neo-Gothic surroundings of Manchester Town Hall. With no parallel sessions, this is the perfect conference to gain insight from basic researchers through to clinical colleagues.
Latest insights from basic and clinical research.
Year(s) Of Engagement Activity 2015,2016
URL http://www.dementiasplatform.uk/event/alzheimers-research-uk-conference-2016/
 
Description ARUK Network Open Morning 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact About 150-200 people attended a morning of talks from Oxford researchers, including presentations on using stem cells in dementia research.
Year(s) Of Engagement Activity 2015,2016
 
Description ARUK Oxford network dementia information event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Open day of talks and information stands organised by Alzheimer's UK Oxford Research Network at John Radcliffe Hospital.
Talk by Sana Suri on Brain-Heart links
Year(s) Of Engagement Activity 2018,2019
URL https://www.oxdare.ox.ac.uk/public-events
 
Description ARUK Roundtable 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I have been invited and participated in a Roundtable discussion organized by Alzheimer's Research UK: "Where now for Alzheimer's disease research? Learning from recent clinical trials failures and planning for the future", 19 January, 2017
Year(s) Of Engagement Activity 2017
 
Description ARUK Technical Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Collaborative workshop to discuss the technical infrastructure of data sharing platforms, including DPUK to facilitate targeted treatments and research. Outcomes have resulted in collaborative networks, invitation to join steering committee, future workshop hosting (DPUK Data Portal), co-hosting of Datathons with ARUK-Turing, collaboration on a grant application and intellectual sharing of ideas.
Year(s) Of Engagement Activity 2018
 
Description ARUK conference 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Lots of questions

More interest in taking part in dementia research
Year(s) Of Engagement Activity 2015
 
Description ARUK scientific meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Awareness raising for DPUK and building networks.
Year(s) Of Engagement Activity 2016
 
Description Alzheimer's & Parkinson's Disease Congress 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PD 2015) will build on the well-earned reputation of previous AD/PD meetings for unraveling the mechanisms and improving the treatment of Alzheimer's, Parkinson's and other related neurodegenerative diseases.
Year(s) Of Engagement Activity 2015
URL http://www.dementiasplatform.uk/events/?yy=2015&mm=3
 
Description Alzheimer's Association International Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International Conference to highlight progress made and new opportunities in dementia research. AAIC attracts international investigators, clinicians and care providers gather to share the latest study results, theories and discoveries.
Year(s) Of Engagement Activity 2016
 
Description Alzheimer's Association International Conference (AAIC) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Present research at AAIC, which is the largest international meeting dedicated to advancing dementia science. The purpose is to disseminate our research and to learn about current and novel research in dementia science.
Year(s) Of Engagement Activity 2016
 
Description Alzheimer's Society Annual Research Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The Dementias Platform UK: what is it and what can it do for you?

The Alzheimer's Society Annual Research conference will take place on 29-30 June 2015 at the Mercure Manchester Piccadilly Hotel. The conference will bring together researchers and people affected by dementia.
Year(s) Of Engagement Activity 2015
URL http://www.dementiasplatform.uk/events/?yy=2015&mm=6
 
Description Alzheimer's Society debate: How can we beat dementia in the next twenty years 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Organised by the Alzheimer's Society. this involved patients, carers, supporters and the media who have had subsequent interest in research. very positive feedback from the Alzheimer's Society who were grateful for the input.
Year(s) Of Engagement Activity 2016
 
Description An invited interview at the Alzheimer's Research UK (ARUK) 2019 the Video Journal of Dementia 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact An interview for Video Journal of Dementia
Year(s) Of Engagement Activity 2019
URL http://www.vjdementia.com
 
Description An invited interview on issues facing researchers in Brexit for the Cross Party Group on Medical Research for Alzheimer's Society, UK 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Have provided an opinion on issues facing researchers in Brexit for the Cross Party Group in the Welsh Assembly looking at Medical Research
Year(s) Of Engagement Activity 2018
 
Description AstraZeneca drug libraries article on DPUK website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Article on Astra Zeneca Drug library screening on DPUK website accessible in the "For Researchers" tab then "Our Research Communities"
Facilitated by DPUK, scientists at the University of Oxford are investigating the behaviour of drugs developed by AstraZeneca (AZ) on patient-specific cell models. They are looking to see if they can be used to target a range of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.
Year(s) Of Engagement Activity 2018,2019
URL https://www.dementiasplatform.uk/our-impact/repurposing-drug-libraries
 
Description Attend Parkinson's UK engagement event at St James' Palace, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Attend reception at St James' Palace to raise awareness for Parkinson's disease
Year(s) Of Engagement Activity 2018
 
Description BBC Horizon - filming 2015-16 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC Horizon were interested in making a programme about Alzheimer's disease with a focus on novel technology - especially imaging - for early diagnosis and trials.
Several meetings were held with the produced and his team and then several days of on-site filming including following a research subject.
The film is due to be shown in Spring 2016 as a one hour long programme which is likely to reach an audience of more than a million
Year(s) Of Engagement Activity 2015,2016
 
Description BBC One Saturday Breakfast News - Funny Side of Parkinson's 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Richard Wade-Martins appeared on BBC One Saturday Breakfast News with Paul Mayhew-Archer to discuss our research using stem cell technology to grow and study dopamine neurons from skin cells.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/health-35734888
 
Description BBC Wales 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact I have given an interview for BBC Wales, broadcasted 20 April 2017
Year(s) Of Engagement Activity 2017
 
Description Big Data - next big thing: evaluation. Presentation to 1st NHS Wales Digital Health and Care Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited talk on the future of health informatics and 'Big Data' for the NHS. The purpose was to demonstrate what was already happening, how evaluations of numerous interventions were being carried out using multi-sectoral data linkage, how this was also supporting DiscoverY Science and the potential for these activities to grow into normal practice for the NHS and wider public services.
Year(s) Of Engagement Activity 2017
 
Description Blog by Bryan Ng on DPUK website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on DPhil student Bryan Ng's project in Richard Wade-Martins' lab.
Disease-in-a-dish studies open a window to a new level of detail in dementia
Year(s) Of Engagement Activity 2019
URL https://www.dementiasplatform.uk/blog/disease-in-a-dish-studies-open-a-window-to-a-new-level-of-deta...
 
Description British NeuroPsychiatric Association Annual meeting 24th February - medalist Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussion of nosological challanges in Dementia
Year(s) Of Engagement Activity 2016,2017
URL http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf
 
Description British Neuropsychiatric Association Annual meeting 24 February - medalist lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussion of nosological challenges in dementia.
Year(s) Of Engagement Activity 2016,2017
URL http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf
 
Description Cecilia (Heyne) Lee Pint of Science Public Engagement Talk, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Pint of Science Public Engagement Talk, Oxford, Autumn 2016 on using iPSC for modelling neurodegeneration
Year(s) Of Engagement Activity 2016
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Talk led to a lot of questions and discussion - for almost an hour after the event

A number of people expressed interest in taking part in research
Year(s) Of Engagement Activity 2014,2015
URL http://www.dementiasplatform.uk/event/cheltenham-science-festival/
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Hands-on experiments, the MakerShack, our brand new Cyber Zone, heartbeat art there was much to explore on site in 2018!

From stargazing, fun activity trails, family days and heated discussions in the Conversation Corner to a large animal dissection live on the Festival site, Cheltenham Science Festival offers science galore for all ages.

Dr Tara Caffrey took part in the day to talk about her research into Tau.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science
 
Description Cheltenham Science Festival (in partnership with Alzheimer's Re-search UK) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Sponsored event - How your life affects your brain.
Can the way you live reduce your chance of developing Alzheimer's? By monitoring groups of people over their lifetimes, and with genetic data, brain scans and medi-cal histories researchers are building as complete a pic-ture as possible of how dementia develops. John Gallacher and Nick Fox join us to show how these stud-ies can uncover the risks involved in developing forms of dementia, and how they can be avoided.
Year(s) Of Engagement Activity 2015
URL http://www.dementiasplatform.uk/events/?yy=2015&mm=6
 
Description Co-organised Synaptic Health Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact A 2 day workshop for the Synaptic Health experimental medicine work package. Attendees were academics and industry scientists involved in the workpackage or who are interested in collaborating. Outcomes were decision to write a number of collaborative research proposals to obtain research funding.
Year(s) Of Engagement Activity 2017
 
Description Comment on the Polygenic Hazard scores for AD study by Tan et al (2019), Brain 142; 460-470 for Alzforum 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I have commented on a study which was covered on Alzforum about polygenic hazard scores for AD, and shared my opinion on their availability to the public.
Year(s) Of Engagement Activity 2019
URL https://www.alzforum.org/news/research-news/multi-gene-score-predicts-cognitive-decline-independentl...
 
Description Competent Authorities for Medical Devices Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Discussion to influence policy and practice relating to medical devices.
Year(s) Of Engagement Activity 2016
 
Description Creation of wademartinslab_oxford instgram account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Account for Wade-Martins lab for Molecular Neurodegeneration, University of Oxford to share news
Year(s) Of Engagement Activity 2018,2019
URL https://www.instagram.com/wademartinslab_oxford/
 
Description DPUK Annual Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact DPUK's annual scientific conference 2017 is open to researchers, funders, government, charities and the public. The keynote speaker will be Monique Breteler. The focus of the day will be on demonstrating tools, presenting data on outcomes to date, and showcasing the complementarity of the Dementia Resource Institute and Dementias Platform UK.

This will be the fourth DPUK conference.
Year(s) Of Engagement Activity 2014,2015,2016,2017
URL http://www.dementiasplatform.uk/event/dementias-platform-uk-annual-conference-2016/
 
Description DPUK Cohort Engagement Seminar 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The purpose of the Cohort Seminar is to provide an overview of the Dementias Platform UK, build relationships with cohorts and formally invite cohorts to be part of DPUK.
Year(s) Of Engagement Activity 2015,2016
URL http://www.dementiasplatform.uk/events/?yy=2016&mm=1
 
Description DPUK Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The DPUK newsletter is issued three times a year.

It regularly includes updates from the Director, notifications of the conference and other events, news on project successes, and information on collaborative activity and any awards available.

Through the newsletter, there is increased engagement from the project's target audiences with DPUK's work and events.
Year(s) Of Engagement Activity 2015,2016,2017
URL http://www.dementiasplatform.uk/info-support/newsletters-and-reports/
 
Description DPUK Stakeholders Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Raised awareness of use of stem cells in dementia research
Year(s) Of Engagement Activity 2015
 
Description DPUK Website feature iPSCs: a shared resource 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Information on iPSC labs on DPUK website accessible in the "For Researchers" tab then "Our Research Communities"
Year(s) Of Engagement Activity 2018,2019
URL https://www.dementiasplatform.uk/our-impact/ipscs-a-shared-resource
 
Description Data Linkage to Cohort Studies. Presentation to CLOSER research group, London - 3/11/14 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Data Linkage to Cohort Studies. Presentation to CLOSER research group, London
Year(s) Of Engagement Activity 2014
 
Description Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff - 27/11/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff
Year(s) Of Engagement Activity 2016
 
Description Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton - 11/10/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton
Year(s) Of Engagement Activity 2016
 
Description Daybreak Lectures on issues around dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Phillippa Carling gave a brief overview of her work on drug discovery lab at ODDI, with some videos of some of their equipment.
Year(s) Of Engagement Activity 2018
 
Description Dementia Awareness Morning - Bryan Ng 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Bryan Ng helped out at a dementia awareness event at the John Radcliffe Hospital.
This was a morning of talks about research into dementia in and around Oxford and a chance for the public to meet researchers and find out about support services available for people living with dementia.
Year(s) Of Engagement Activity 2018
URL https://www.oxdare.ox.ac.uk/public-events
 
Description Dementia and Neurodegeneration Network Ireland (DNNI) Inaugural conference (30 November 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact explore current research/future directions in the Dementia/Neurodegeneration field, effective funding models for research and the importance of interdisciplinary collaboration.
Year(s) Of Engagement Activity 2017
URL https://www.eventbrite.ie/e/dnni-conference-2017-tickets-37728733658#
 
Description Dementia and a Research Institute - Interview in the Sun Newspaper 5Oct15 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Publicity to promote the fact that 5p from each carrier bag bought would be donated to the Dementia Research Centre. This was the brainchild of Malcolm Walker (Iceland) with Nick Fox (DRC)
Year(s) Of Engagement Activity 2015
URL http://www.thesun.co.uk/sol/homepage/woman/health/health/6735025/5p-bags-could-help-combat-dementia....
 
Description Dementia: population and public health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A talk was given for the visit of the DRI director on 19 October 2016 at the University of Cambridge, IPH.
Year(s) Of Engagement Activity 2016
 
Description Dementias Platform UK (DPUK) Scientific Symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The purpose of the Symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically looking at the main themes of Cohorts, Networks and Experimental Medicine.
Year(s) Of Engagement Activity 2015,2016
 
Description Dementias Platform UK (DPUK) scientific symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The purpose of this symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically look at the main themes of Cohorts, Networks and Experimental Medicine
Year(s) Of Engagement Activity 2015,2016,2017,2018
 
Description Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board - 15/12/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board, London
Year(s) Of Engagement Activity 2015
 
Description Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London - 24/11/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London
Year(s) Of Engagement Activity 2015
 
Description EPAD consortium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attendance at event to collaborate with partners to share progress in dementia research.
Year(s) Of Engagement Activity 2016
 
Description Ethical Risk Assessment in Biomedical Big Data - Protecting privacy through design 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Protecting privacy through design
Year(s) Of Engagement Activity 2016
 
Description European Brain Council Strategic Workshop (13 and 14 September 2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact EBC members and people working in the Value of Treatment White Paper. To explore new areas of project development for the EBC and the continuation of their Value of Treatment White Paper.
Year(s) Of Engagement Activity 2017
 
Description European Medical Information Framework 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact More than 75 EMIF team members gathered in Budapest March 14-16, 2016 to not only share status updates on the ongoing work, but also discuss new joint AD/Metabolic scientific questions to be addressed using the EMIF framework.

Overall, tremendous progress was shown for both research projects, with many more exciting results being underway and opportunities for further collaboration identified. In particular the overlap between AD and metabolic disorders, due to inflammation, such as in Diabetes Mellitus Type 2, has provided opportunities for shared work.
Year(s) Of Engagement Activity 2016
URL http://www.emif.eu/news?news_news=5
 
Description European Medical Information Framework conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research conference to demonstrate use of new tools and methods for the dementias research community.
Year(s) Of Engagement Activity 2017
URL http://www.emif.eu/
 
Description External talk at the ITMAT workshop on data science challenges and opportunities in Translational Medicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Talk to influence research on data science challenges.
Year(s) Of Engagement Activity 2017
 
Description Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference - 24/8/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference, Swansea
Year(s) Of Engagement Activity 2016
 
Description Generation Scotland Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Awareness raising for DPUK and building networks.
Year(s) Of Engagement Activity 2016
 
Description Hong Kong University - international lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact These numerous lectures provided DPUK in depth overview and dementia related discussions.
Year(s) Of Engagement Activity 2015
 
Description Inaugural academic conference: Tools for science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Inaugural conference for Dementias Platform UK to engage researchers in our academic and industry partner institutions and beyond. Presentations from speakers covering all areas of the Dementia Platform and cohorts encouraged to join the platform. Engagement of early career researchers through a poster presentation competition.

37 posters were exhibited, some with interactive stands, and demonstrated the progress of work delivered through the DPUK Work Programme and Infrastructure Networks.

Dr Carol Routledge discussed the opportunities available through the Dementia Discover Fund and Maria Carrillo, PhD, Chief Science Officer from Chicago gave her first impression of DPUK "The Dementias Platform UK and Alzheimer's Association have a lot of opportunity to collaborate in the future in my view and John Gallacher and his team have also agreed with that, and this is one of the reasons why we have been asked to listen in and help future thinking and brainstorm ideas that might come about with DPUK's established network."
Year(s) Of Engagement Activity 2016
URL http://www.dementiasplatform.uk/tools-for-science-dpuks-first-annual-conference-in-brief/
 
Description Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London - 19/10/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London
Year(s) Of Engagement Activity 2015
 
Description Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London - 23/11/15 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London
Decision made that a Neurodevelopmental Disorders Research Network would require a data platform similar to the Dementias Research Platform UK
Year(s) Of Engagement Activity 2015
 
Description Insight 46 launch facebook offices 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Talk sparked questions and included George Freeman MP - Minister for Life Sciences

A number of members of the audience asked for further information
Year(s) Of Engagement Activity 2015
 
Description International Alzheimer's Disease Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participation in international conference. This was an opportunity to share progress and updates in dementia research infrastructure with Alzheimer's Disease Research Network, SRT Ageing, & Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong Co-organized this with the Faculty of Architecture, Faculty of Social Sciences, Sau Po Centre on Ageing & SRT Science of Learning, The University of Hong Kong, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Shenzhen University (College of Life Sciences), Hong Kong Science & Technology Parks Corporation, & The Hong Kong Society of Aging Research.
Year(s) Of Engagement Activity 2016
 
Description Interview in Civil Service Fast Stream blog - How Stem Cells Can Boost Our Knowledge and Understanding of the Causes of Dementia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This is the third and final in a series of interviews carried out by a group of civil servants that have dedicated time to raising money and awareness for dementia via 'The Fund', a Fast Stream initiative. Alison Leishman, Home Office, interviewed Professor Wade-Martins about his research into dementia.
Richard discussed OPDC and the DPUK.
Year(s) Of Engagement Activity 2016
URL https://faststream.blog.gov.uk/2016/05/20/the-fascinating-world-of-research/
 
Description Janssen Symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Discussion and collaboration with industry partners.
Year(s) Of Engagement Activity 2016
 
Description Joint Programme for Neurodegenerative Disease (JPND) Scientific Advisory Board (SAB) strategic workshop on precision medicine (13 March 2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The purpose of the workshop is to bring together clinicians, basic scientists and industry scientists to examine how the precision/stratified medicine concept can be applied to neurodegenerative disease research.
Year(s) Of Engagement Activity 2017
 
Description Late night event at The Science Museum 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Launch of the MRC UK Dementias Platform, Royal Society, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact More than 200 people attended the conference launch. I presented as leader of the Informatics Platform Work Package in the morning and the interactive discussion with industry in the afternoon

a number of contacts were made with industry colleagues with plans for follow up meetings
Year(s) Of Engagement Activity 2014
URL http://www.mrc.ac.uk/research/facilities/dementias-research-platform-uk/
 
Description MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London - 6/7/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London
Year(s) Of Engagement Activity 2016
 
Description MS Society Public Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact A presentation to members of the MS Society
Year(s) Of Engagement Activity 2016
 
Description Medicine and Me: Living well with Dementia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Giving a talk on types and diagnosis of dementia at this half day meeting.

The Medicine and Me series of meetings at the RSM aim to update on important conditions and gives a direct voice to patients and their carers to air their concerns on the impact of diagnosis, investigation and management. Physicians and surgeons and indeed all healthcare professionals continue to learn from and be inspired to greater efforts by our patients to improve care.
The audience at this meeting will comprise of those living with dementia, their families, carers and advocates, representing about 70% of those present; and clinicians and researchers, representing not more than 30%. Clinicians will include doctors, specialist nurses and others involved in the treatment and care of those who have this condition
Year(s) Of Engagement Activity 2016
URL https://www.rsm.ac.uk/events/events-listing/2015-2016/groups/public-engagement-programme/mmg01-medic...
 
Description Meetings with Insight46 donors via ARUK 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Meeting with Insight46 donors via ARUK to discuss Insight46 and dementia research.
Year(s) Of Engagement Activity 2016
 
Description Melodem progress meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participation in a progress meeting for dementia researchers.
Year(s) Of Engagement Activity 2016
URL http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Agenda_Melodem_30June-and-1-july-2016_v1....
 
Description Mental Health Data Science Meeting (event part-funded by Farr Institute CIPHER) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Assessment of complex interventions using routine data
Year(s) Of Engagement Activity 2016
 
Description Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods - 6/7/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods, Bath
Year(s) Of Engagement Activity 2016
 
Description NHS Lothian Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Clinical Research : driving efficient, innovative and effective healthcare.
Year(s) Of Engagement Activity 2016
 
Description Nora Bengoa-Vergniory article on Celgene Fellowship 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Interviwe with Dr Nora Bengoa-Vergniory on her experience as a Celgene Fellow for the Oxford University Medical Sciences division website
Year(s) Of Engagement Activity 2018
URL https://www.medsci.ox.ac.uk/research/internal/funding-directory/oxford-celgene-fellowship/oxford-cel...
 
Description November 2016, WISH Summit (Qatar) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2016
 
Description OPDC Open Day 2016 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact OPDC Open Day 2016
250 OPDC study Participants and Partners registered for event.
Day of talks from Michele Hu, Fahd Baig, Claudio Ruffmann, Tom Barber and Richard Wade-Martins.
Discussion of what participants would like from study.
Talks filmed and podcasts added to website
Year(s) Of Engagement Activity 2016
URL http://www.opdc.ox.ac.uk/openday2016
 
Description OPDC Open Day talks online 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact A series of talks recorded at the 2018 OPDC Particpant's day are available to view on our YouTube channel and on our website.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/videos
 
Description OPDC Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact We held a research day to present an update on current Parkinson's research in the region and invited members of our SAB from overseas to present their work.
This was attended by researchers from accross Oxford as well as members of the local Parkinon's UK group and interested study participants.
We invited Hazel Stanyon, a study partiicpants who apoke about her experiences of how exercise has helped her Parkinson's symptoms and shared a poem.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/research2018
 
Description OPDC YouTube channel 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Creation of OPDC YouTube channel to collate our podcasts etc.
32 subscribers, >2,860 views Feb 2016-Jan 2017.
2016 talks >1,450 views,
2016 OPDC highlights video >350 views,
2015 talks >1,000 views
Year(s) Of Engagement Activity 2015,2016
URL http://www.youtube.com/channel/UCGzboizARwaAUFW5FjPmmZw
 
Description Oxford Dementia Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The event showcased the latest developments in memory, dementia and ageing research from cells and animal models to cognitive neuroscience and the clinic.
Year(s) Of Engagement Activity 2016
URL https://www.dpag.ox.ac.uk/research/wade-martins-group/oxford-aruk-network-centre/research-day-2015
 
Description Oxford Sparks'animation about the role of microglia in neurodegeneration 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Postdoc Hazel Roberts won Oxford Sparks' competition to have an animation made about the role of microglia in neurodegeneration. Title: Discovering life-changing dementia treatments.

Your beautiful, complex brain is a network of microscopic cells that connect together to form your thoughts and personality, and control your body. The network is fragile and requires constant upkeep, like a garden. The brain has its own gardeners, specialised cells called microglia. In this animation we look at how researchers at the University of Oxford are developing drug treatments for Alzheimer's disease, by harnessing the power of the brain's microglia.
Year(s) Of Engagement Activity 2018
URL https://www.oxfordsparks.ox.ac.uk/content/discovering-life-changing-dementia-treatments
 
Description Parkinson's Oxford Walk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact Members of OPDC took part in Parkinson's UK Oxford Walk. OPDC also hosted an information stand at the event.
Year(s) Of Engagement Activity 2018
URL https://www.parkinsons.org.uk/events/walk-parkinsons-oxford
 
Description Parkinson's UK Blog Post on HDAC paper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Blog by Claire bale on Parkinson's UK Blog
Using brain cells grown from skin to find new potential drugs
Researchers in Oxford are using pioneering stem cell techniques to understand the earliest problems that occur inside brain cells in Parkinson's - and hunt down new drugs that can tackle them.
Year(s) Of Engagement Activity 2018
URL https://medium.com/parkinsons-uk/using-brain-cells-grown-from-skin-to-find-new-potential-drugs-78f56...
 
Description Pharma partnerships under CDA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A series of six pharma partnership meetings related to PSP and FTD novel therapeutics, under CDA/NDA
Scoping the needs and opportunity, reviewing candidate product preclinical data, and developing better trial design,
Year(s) Of Engagement Activity 2018
 
Description Plenary Speaker at Clinical Trials in Alzheimer's Disease (CTAD) conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Plenary Speaker at European Academy of Neurology on Imaging Trials and Dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Plenary speaker: Cypriot Neurological Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2015
 
Description Plenary speaker: The neurology of ageing, ABN Annual Meeting, Brighton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Population data and modelling: dementia as exemplar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A talk was given at the Cumberland Initiative Festival of Evidence on 5 October 2016.
Year(s) Of Engagement Activity 2016
 
Description Poster at Advances in Neurodegenerative Disease Research and Therapy/New Frontiers in Neuroinflammation Keystone Conference, Colorado USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Nora Bengoa-Vergniory poster
"Tau-proximity ligation assay detects pathology ahead of tau neurofibrillary tangles in Alzheimer's disease"

As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.
Year(s) Of Engagement Activity 2018
URL http://www.keystonesymposia.org/18Z3
 
Description Poster presentation at CTAD conference, Barcelona 24-27th October 2018: Psychometric methodologies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentaton of research work entitled: Psychometric methodologies to increase scale-reliability in dementia-focused epidemiology: Outcomes from the European Prevention of Alzheimer's Disease Study & UK Biobank. This work will be published in a peer reviewed journal at a later date. This work has gained great interest from the epidemiological community and further work in this field is planned as well as a grant application.
Year(s) Of Engagement Activity 2018
URL http://www.ctad-alzheimer.com/
 
Description Presentation at High Performance Computing and Big Data Conference, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation title - Improving health through Big Data

-
Year(s) Of Engagement Activity 2014
 
Description Presentation at International Health Data Linkage Conference, Vancouver 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation title - Using data linkage to support measurement of the Global Burden of Injuries

-
Year(s) Of Engagement Activity 2014
 
Description Presentation at MRC Strategic meeting between health and bioinformatics centres - 29/1/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Centre for Improvement of Population Health through E-records Research (CIPHER). Presentation at MRC Strategic meeting between health and bioinformatics centres, Windsor
Year(s) Of Engagement Activity 2015
 
Description Presentation at MRC organised conference: Strengthening the UK's capability in health informatics research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation as MRC organised conference: Strengthening the UK's capability in health informatics research. Conference was attended by 200+ delegates including, UK Minister, policymakers, research community and industry

Agreement to create the Farr Institute; development of the UK Health Informatics Research Network
Year(s) Of Engagement Activity 2013
 
Description Presentation on Health / Bioinformatics at Swansea University. Visit of Prof Julie Williams, Chief Scientific Advisor for Wales 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact -
Year(s) Of Engagement Activity 2014
 
Description Presentation on UK Secure eResearch Platform (DPUK) - 24/11/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on UK Secure eResearch Platform (DPUK) at MRC meeting 'Managing the data life-cycle for stratified medicine', London
Year(s) Of Engagement Activity 2015
 
Description Presentation on future Farr UK Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on future Farr UK Institute to MRC Population Health Sciences Group, London
Year(s) Of Engagement Activity 2015
 
Description Presentation on research at Farr Institute CIPHER to Rebecca Endean - 26/1/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation on research at Farr Institute CIPHER to Rebecca Endean, Director Research Base, Business and Science
Year(s) Of Engagement Activity 2016
 
Description Presentation to Clinithink, Swansea - 10/4/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact NLP of Emergency Department data: Early experience. Presentation to Clinithink, Swansea
Year(s) Of Engagement Activity 2015
 
Description Presentation to MRC Council - Centre for the Improvement of Population Health through E-records Research (CIPHER) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Presentation to MRC Council on the success of the Farr CIPHER centre and its impact through science and public engagement, including the development of data sharing research platforms that underpin a number of major research initiatives, including DPUK and MQ Adolescent Mental Health Platform
Year(s) Of Engagement Activity 2017
 
Description Presentation to Precision Medicine Catapult - 17/11/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation to Precision Medicine Catapult tem leaders from Cambridge University at visit to Swansea University

Precision Medicine Catapult team asked to come back to discuss opportunities and projects in more detail
Year(s) Of Engagement Activity 2015
 
Description Presentation to UK Biobank and Oxford Big Data Institute, Swansea 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation title - Use of UK Secure e-Research Platform (UKSeRP)

-
Year(s) Of Engagement Activity 2014
 
Description Presentation to joint meeting of UKDP, EMIF (European Medical Information Framework) and eTRIKS (European Translational Information and Knowledge Management Services), London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Presentation title - UK Dementia Platform Informatics

-
Year(s) Of Engagement Activity 2014
 
Description Presentation to the MEPs about DPUK, EPAD and ROADMAP 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Presentation to MEPs about DPUK, EPAD and ROADMAP.
Year(s) Of Engagement Activity 2016
 
Description Presentation to the general public on the DRI program at the DRI launch in Cardiff 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I have presented on my DRI program "Bioinformatics and Functional genomics" to patients, their families, journalists and other invited guests from the general public at the DRI launch in Cardiff, October 2018.
Year(s) Of Engagement Activity 2018
 
Description Presentation with Mick Dennis (Swansea) and Daniel Davies (UCL) to UK Biobank/DPUK neorodegerative outcomes group - 6/1/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Research Proposal: Dementia and Cognitive Impairment identification in routine health data: development and validation of algorithms within SAIL using CFAS cases.
Year(s) Of Engagement Activity 2015
 
Description Privacy protecting data linkage for population health. Presentation for Fondazione Lanza, Padua - 2/12/14 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Privacy protecting data linkage for population health. Presentation for Fondazione Lanza, Padua
Year(s) Of Engagement Activity 2014
 
Description Prof Joanna Wardlaw feature in Health Matters magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A feature in Health Matters magazine, Winter 2018-2019 issue, P 24-25. Wardlaw, JM. "MRI scans of the brain".
Year(s) Of Engagement Activity 2019
 
Description Prof Joanna Wardlaw lecture "Brain Health: a small matter of the blood vessels" in Edinburgh, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Edinburgh Neuroscience Public Christmas Lecture 2018
Year(s) Of Engagement Activity 2018
 
Description Q&A session at Rare Dementia Support Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Question and Answer session from patients and carers with a diagnosis of frontotemporal dementia
Year(s) Of Engagement Activity 2017
 
Description Radio Interviews on Parkinson's 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Radio interview to raise awareness and Parkinson's fund raising sponsored event

Raised awareness and money
Year(s) Of Engagement Activity 2015
 
Description Rare Dementia Support Group Launch 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Rare Dementia Support Fund created with the ambition to increase fundraising and extend the support service further, throughout the UK and beyond.
Extremely well attended
Year(s) Of Engagement Activity 2016
URL http://www.nationalbrainappeal.org/rare-dementia-support-launch-event/
 
Description Royal College of Physicians 'Women in medicine: a celebration' project 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Royal College of Physicians (RCP)'s 'Women in medicine: a celebration' project is a free exhibition of specially commissioned photographic portraits to honour contemporary and historical women in medicine. The project showcased a number of today's leading female clinicians and the women from the history of medicine who have inspired them. Prof Joanna Wardlaw is featured in the project alongside someone who inspired her, Marie Sklodowska Curie: https://www.rcplondon.ac.uk/projects/outputs/women-medicine-joanna-wardlaw-and-marie-curie
Year(s) Of Engagement Activity 2017
URL https://www.rcplondon.ac.uk/events/women-medicine-celebration
 
Description School of Medicine 'Science in Health' Public Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Professor John Gallagher spoke at a Cardiff University public medical lecture and the aim of these lectures is to open up areas of concern in health care, and second, to inform the public about current medical research.
Year(s) Of Engagement Activity 2016
URL http://www.dementiasplatform.uk/event/school-of-medicine-science-in-health-public-lecture/
 
Description Section on DPUK website to formally request stem cell lines 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact A section on iPSC resources for researchers on the DPUK website provides the opportunity for researchers to formally request over 100 stem cell lines derived from healthy and diseased individuals. This resource focused section is complemented by two detailed reports in the "Our impact" section of the web-site.
Year(s) Of Engagement Activity 2018,2019
URL https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso...
 
Description Secure Anonymised Information Linkage (SAIL) system. Educational presentation to the Confidentiality Advisory Group, Health Research Authority - 7/9/16 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Secure Anonymised Information Linkage (SAIL) system. Educational presentation to the Confidentiality Advisory Group, Health Research Authority, London
Year(s) Of Engagement Activity 2016
 
Description Social Media 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The social media presence of Dementias Platform UK is intended to demonstrate the core personality of the project, sharing:
- Expert voice
- A network of research excellence
- Human connection.

DPUK's social media presence is focused on Twitter, though in the future it may also reach LinkedIn.

Social media is used to share updates on the project's work: its research, daily activity, funding awards open, news, and any open recruitments, It also demonstrates its networked and human approach by sharing content from charities, linked researchers and any current human interest news stories. Finally, in the coming months it will strengthen its ability to share its expert voice by facilitating twitter takeovers from key researchers, particularly Early Career Researchers.

DPUK has 1,636 followers - a 173% increase on 2016.
Year(s) Of Engagement Activity 2006,2015,2016,2017
URL https://twitter.com/dementiasuk
 
Description Speaker at Primary Progressive Aphasia: BNPA Annual Meeting, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Speaker at launch of UK Dementia Platform 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Oxford plays a significant role in the partnership and Oxford Neuroscience researchers lead a number of projects. This was reflected in the scientific programme of launch day. Simon Lovestone (Psychiatry) gave a talk on the NIHR-MRC Dementia Deep and Frequent Phenotyping Feasibility Study while Richard Wade-Martins (DPAG) spoke on the UK Stem Cell Network.

Coverage in the media
Year(s) Of Engagement Activity 2014
URL http://www.dementiasplatform.uk/
 
Description Speaking Cambridge Dementia Course: MRI in dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Speaking at EAN, Copenhagen, Focal dementias, Convener, lecturer 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Speaking re fluid biomarkers in AD. Educational Workshop. AAIC, Toronto 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Speaking re young onset dementia: Royal college of Physicians, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Synaptic Health Symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A one-day workshop, and shorter follow up meetings, to engage academic and industry partners in Synaptic Health Research
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/for-researchers/expert-communities-1/synaptic-health-community
 
Description Talk at East Midlands Research Support Network 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Natalie Connor-Robson - invited talk outreach, East Midlands Research Support Network, Sept 2018
Understanding Parkinson's disease - what can we learn from skin cells and mice?

The East Midlands Parkinson's Research Forum is a free annual conference organised by the local Parkinson's community and supported by Parkinson's UK.

The event will feature talks from top Parkinson's researchers and healthcare practitioners, Parkinson's UK staff, volunteer speakers, as well as interactive exercise sessions and a performance from The Parkinson's Choir.
Year(s) Of Engagement Activity 2018
URL https://www.parkinsons.org.uk/events/east-midlands-parkinsons-research-forum
 
Description Talk at Parkinson's UK Branch Richard Wade-Martins 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Prof Richard Wade-Martins on the latest projects at the Oxford Centre for Parkinson's Disease Research
Year(s) Of Engagement Activity 2016
 
Description The Impact of Incidence Prior to Death on the Incidence of Dementia in individuals Aged 65 Years and Older 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited speak at Alzheimer's Association International Conference AAIC 2017 London.
Year(s) Of Engagement Activity 2017
 
Description The Many Faces of Dementia - massive open online course (MOOC) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I was interviewed for an online course about the rarer forms of dementia, my interview related to the clinical features of frontotemporal dementia. I also performed the voice over and welcome to the course that appeared in the course trailer video. The course, due to start March 14th 2016 is a 'massive open online course' available at www.futurelearn.com/courses/faces-of-dementia. Over 12,000 people have registered for the course (as of 8th March 2016).
Year(s) Of Engagement Activity 2015
URL https://www.futurelearn.com/courses/faces-of-dementia
 
Description The Times 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I have given an interview to "The Times" newspaper published 22 March, 2017
Year(s) Of Engagement Activity 2017
 
Description Transforming UK Biomedical and Health Informatics. Lecture to MSc in Health Data Analytics students, Swansea - 26/10/15 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Transforming UK Biomedical and Health Informatics. Lecture to MSc in Health Data Analytics students, Swansea
Year(s) Of Engagement Activity 2015
 
Description Twitter account for OPDC 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Active twitter feed for OPDC engages with other research groups and industry.
Promotes our research, events, news and drives for study participants as well as highlighting relevant news items and publications.
Jan 2019: 829 followers, average Impressions 10.6k per month
Year(s) Of Engagement Activity 2015,2016,2017,2018,2019
URL http://twitter.com/OxfordPDCentre
 
Description UK Medical Research Council open meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Discussion forum with partners in the dementia research field.
Year(s) Of Engagement Activity 2016
 
Description Vascular risk factors in AD and other dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Personal invited to give talk at CoSTREAM Meeting of University of Cambridge.
Year(s) Of Engagement Activity 2017
 
Description WHO Bulletin Interview with Carol 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Carol Brayne: a life-course approach to prevent dementia
https://apps.who.int/iris/handle/10665/272247
WHO Bulletin Interview with Carol
Year(s) Of Engagement Activity 2018
URL https://apps.who.int/iris/handle/10665/272247
 
Description Westminster forum 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Advice for policymakers on dementia research.
Year(s) Of Engagement Activity 2017
URL http://www.westminsterforumprojects.co.uk/conference-diary
 
Description Work with artist to produce cartoons of research 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Abstracts of posters were presented by DPAG Graduate Students at the start of their Second Year of DPhil Research Study. A cartoonist was on hand again to record the event and produced cartoons to illustrate the projects which were shared via social media.
Year(s) Of Engagement Activity 2018
URL https://twitter.com/WadeMartinsLab/status/1074587251496095745
 
Description World Innovation Summit for Health (WISH) forum (February 2015) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participated as a panel member looking at issues of dementia funding and research, and how to better inform the public. A report was subsequently published based on the Summit meeting.
Year(s) Of Engagement Activity 2015
URL http://www.nhsq.info/app/media/4053
 
Description Young Onset and Rare Dementias 2014 event at House of Lords 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Awareness-raising event regarding young onset and rare dementias
The event was attending by member of parliament and the House of Lords as well as charities, patient families and other organisations
Year(s) Of Engagement Activity 2014
URL https://www.youngdementiauk.org/news/young-onset-awareness-event-house-lords
 
Description led a session on macrophages and microglia in a Stem Cell Outreach workshop for GCSE school students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Sally Cowley led a session on macrophages and microglia in a Stem Cell Outreach workshop for GCSE school students, Medical Sciences Teaching Centre, Oxford University
Year(s) Of Engagement Activity 2018