UK Dementias Platform
Lead Research Organisation:
Cardiff University
Department Name: School of Medicine
Abstract
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, bringing together data from around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of slowing it down. The platform has been funded to the level of £4.5M and invited to apply for a further £7.5M.
To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.
We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.
There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.
There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.
To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.
Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.
To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.
We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.
There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.
There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.
To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.
Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.
Technical Summary
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and cost-effective translation pipeline from basic discovery through to early phase trials (Fig 1). By combining the analytic and statistical power of >20 clinical and population cohorts representing 2M participants and creating a large readiness cohort, UKDP will create an optimal environment for basic discovery activities relevant to the clinical progression and human impact of dementia. Although UKDP is intended as a strategic and sustainable resource generating increasing scientific benefit over time, it will also deliver short and medium term benefits through the analysis of existing data, the enrichment of strategically selected cohorts, developing new ways of working with industry, and generating interest and further funding for dementias research generally.
A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.
Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.
A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.
Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.
Planned Impact
The platform will use several vehicles to deliver impact.
These were described in stage 1.
In summary:
For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
These were described in stage 1.
In summary:
For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
Organisations
- Cardiff University, United Kingdom (Collaboration, Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- Janssen Research & Development (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Eisai Ltd (Collaboration)
- Alan Turing Institute (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- SomaLogic (Collaboration)
- Janssen Biotech, Inc. (Collaboration)
- University of Cambridge (Collaboration)
- Johnson & Johnson Ltd, United Kingdom (Collaboration)
- AstraZeneca plc (Collaboration)
- Amyloid Imaging to Prevent Alzheimer's Disease (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Alzheimer's Research Uk (Collaboration)
- University of Oslo, Norway (Collaboration)
- Eli Lilly & Company Ltd (Collaboration)
- University of Luxembourg (Collaboration)
- University of Porto (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- The International Parkinson Disease Genomics Consortium (Collaboration)
- MRC Dementias Platform UK (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- JPND Research (Collaboration)
- University of Exeter, United Kingdom (Collaboration)
- National Institutes of Health, United States (Collaboration)
- Catalan Health Institute (ICS) (Collaboration)
- Wellcome Trust, LONDON (Collaboration)
- Araclon Biotech (Collaboration)
- University of Liege, Belgium (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- Oxford University Hospitals NHS Foundation Trust (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
- Ixico (Collaboration)
- King's College London, United Kingdom (Collaboration)
Publications

A N
(2019)
Viscosity and fragility of confined polymer nanocomposites: a tale of two interfaces
in Nanoscale


Agarwal D
(2020)
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders.
in Nature communications

Ahmad S
(2018)
Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study.
in Alzheimer's & dementia : the journal of the Alzheimer's Association

Akbari A
(2020)
Creating A Research Ready Data Asset and Empowering Dynamic and Efficient Research: The Sail Dementia E-Cohort (SDEC)
in International Journal of Population Data Science

Alex B
(2019)
Text mining brain imaging reports.
in Journal of biomedical semantics

Allan CL
(2016)
Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort.
in Journal of affective disorders

Allardyce J
(2018)
Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.
in JAMA psychiatry

Allen N
(2020)
Disability Evaluation and Treatment for Patients With Psychiatric Disorders
in Mayo Clinic Proceedings

Allen N
(2020)
Mirtazapine's effect on the QT interval in medically hospitalized patients
in Mental Health Clinician
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Start |
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Start |
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Sector | Public |
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Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start |
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Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2016 |
End | 06/2020 |
Description | Maria Claudia Caiazza was awarded an ARUK Thames Valley network Pilot Award |
Amount | £2,500 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2021 |
End | 06/2021 |
Description | Mental Health Pathfinder Award |
Amount | £1,000,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | Michael J Fox Foundation: Transcriptomic changes in iPSC-derived dopaminergic neurons induced by exposure to alpha-synuclein revealed by single cell RNA-Seq. |
Amount | $200,000 (USD) |
Organisation | Michael J Fox Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 03/2021 |
End | 09/2022 |
Description | Michael J Fox Foundation: Validation of FASN as a target for therapeutic development in PD.(Prof Wade-Martins) |
Amount | $200,000 (USD) |
Organisation | Michael J Fox Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 03/2021 |
End | 11/2022 |
Description | Natalie Connor-Robson Lockey Fund- for travel to World Parkinson's congress |
Amount | £500 (GBP) |
Organisation | Lockey Committee |
Sector | Academic/University |
Country | United Kingdom |
Start | 05/2019 |
Description | Natural Sciences and Engineering Research Council of Canada DPhil Scholarship, and Clarendon Award (Co-supervisors to Kaitlyn Cramb Prof. Richard Wade-Martins & Prof Stephanie Cragg ). In vitro iPSC-derived neuronal circuit models of Parkinson's |
Amount | £117,000 (GBP) |
Organisation | Natural Sciences and Engineering Research Council of Canada (NSERC) |
Sector | Public |
Country | Canada |
Start | 09/2019 |
End | 09/2022 |
Description | New Therapeutics in Alzheimer s Disease (NTAD) - ARUK |
Amount | £100,000 (GBP) |
Funding ID | RG89702 |
Organisation | Versus Arthritis |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2017 |
End | 08/2020 |
Description | Oxford Interdisciplinary Bioscience Doctoral Training Partnership (DTP) - Sally Cowley |
Amount | £90,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2019 |
End | 09/2023 |
Description | Oxford Parkinson's Disease Centre Discovery Cohort PBMCs for T cell reactivity study |
Amount | £78,528 (GBP) |
Organisation | Bristol-Myers Squibb |
Department | Celgene |
Sector | Private |
Country | United States |
Start | 08/2018 |
End | 09/2019 |
Description | Peter Kilfeather awarded funding to study using spatial transcriptomics to look at SNpc and VTA gene expression on wild-type mice compared to SNCA-OVX mice. |
Amount | £22,151 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2021 |
End | 12/2021 |
Description | Post-Doctoral Fellowship (Supervisor to Dr Charmaine Lang): (£210,000; 01/10/19-30/09/21) New molecular targets in Parkinson's disease. |
Amount | £210,000 (GBP) |
Organisation | AstraZeneca |
Sector | Private |
Country | United Kingdom |
Start | 09/2019 |
End | 09/2021 |
Description | ROADS IMI2 call 6 |
Amount | € 4,000,000 (EUR) |
Organisation | European Commission |
Department | Innovative Medicines Initiative (IMI) |
Sector | Public |
Country | Belgium |
Start | 08/2016 |
End | 08/2018 |
Description | SRUK winter studentship |
Amount | € 2,400 (EUR) |
Organisation | Society of Spanish Researchers in the United Kingdom |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Sanofi/Genzyme: Modulating GBA activity as a Parkinson's disease therapy |
Amount | £200,000 (GBP) |
Organisation | Sanofi |
Department | Genzyme Therapeutics Ltd |
Sector | Private |
Country | United Kingdom |
Start | 11/2016 |
End | 10/2017 |
Description | Targeting HDAC4 in Parkinson's disease |
Amount | £50,000 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2020 |
End | 02/2021 |
Description | Targeting disease phenotypes in Parkinson's patient iPSC-derived dopamine neurons |
Amount | £650,000 (GBP) |
Organisation | GlaxoSmithKline (GSK) |
Sector | Private |
Country | Global |
Start | 09/2020 |
End | 09/2022 |
Description | The Airwave Health Monitoring Study (AHMS). An Occupational Cohort Study of the British Police Forces |
Amount | £1,941,097 (GBP) |
Funding ID | MR/R023484/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2018 |
End | 04/2023 |
Description | The development of digital biomarkers for dementia |
Amount | £1,200,873 (GBP) |
Organisation | Eli Lilly & Company Ltd |
Sector | Private |
Country | United Kingdom |
Start | 12/2016 |
End | 11/2022 |
Description | Travel grant for conference for Bryan Ng |
Amount | £300 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2020 |
Description | Travel grant for conference for Bryan Ng |
Amount | £300 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2020 |
Description | Travel grant for conference for Bryan Ng |
Amount | £300 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2019 |
End | 03/2019 |
Description | UK Dementias Platform |
Amount | £13,607,814 (GBP) |
Funding ID | MR/L023784/2 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2015 |
End | 06/2019 |
Description | Uniting iPCS and CRISPR/Cas9 screens- a platform to model and interrogate genetic disease in Oxford |
Amount | £80,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2018 |
End | 09/2019 |
Description | Wellcome Integrative Neuroimaging Seed funding - £12,000 . Natalie Connor-Robson |
Amount | £12,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | Wellcome Trust Clinical Training Fellowship |
Amount | £174,791 (GBP) |
Organisation | Wellcome Trust |
Department | Wellcome Trust Bloomsbury Centre |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2016 |
End | 03/2019 |
Description | Wellcome Trust DPhil Studentship in Neuroscience: Characterisation of a novel GBA-L444P BAC transgenic mouse model of Parkinson's. (Supervisor to Tara Diviney, Co-Supervisor Prof Stephanie Cragg |
Amount | £104,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2020 |
End | 09/2023 |
Description | What makes strategic stroke strategic? Multimodal imaging and network methods to predict dementia after strategic stroke |
Amount | £4,000 (GBP) |
Organisation | Alzheimer's Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2017 |
End | 08/2017 |
Description | renewal funding for the Alzheimer Scotland Dementia Research Centre, An objective of the Centre was to leverage external funding which DPUK funding helped to meet. |
Amount | £750,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2016 |
End | 04/2020 |
Title | CRISPR gene editing |
Description | We have been able to establish CRISPR/Cas9 gene editing in our lab as a result of this project |
Type Of Material | Technology assay or reagent |
Year Produced | 2015 |
Provided To Others? | Yes |
Impact | We have been able to perform gene editing in iPSC lines. |
Title | Cognitive test battery implemented in UK Biobank |
Description | DPUK has developed a cognitive test battery suitable for use in large-scale population studies. |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | The battery has been deployed in the UK Biobank study |
Title | DPUK Data Portal Datathon Virtual Desktop |
Description | Bespoke virtual desktop infrastructure for DPUK Datathons - comprising of dedicated 32GB RAM/4 CPU machines supporting up to 60 concurrent users. Pre-loaded with software such as Stata 16, SPSS, SAS, R, Python (Anaconda), PyCharm, Spyder, Jupyter Notebook, Eclipse, SQL Server Management Studio, Matlab, and Office. |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | The dedicated Datathon desktop has allowed us to run 4 DPUK Datathon events across the UK, which have had an international audience of over 150 researchers cumulatively. |
URL | https://portal.dementiasplatform.uk/ |
Title | DPUK data portal |
Description | The DPUK secure data analysis platform for dementia research brings together over 30 UK cohorts (n=2M) for data sharing. This is a step-change in UK data sharing capacity |
Type Of Material | Improvements to research infrastructure |
Provided To Others? | No |
Impact | By bringing the researcher to the data , the DPUK data portal reduces the transaction costs of data sharing at many levels. The concept has proven attractive to researchers form France, Netherlands, China, Japan, South Korea, Canada and the US and discussions are underway with these colleague to include their data within the portal. |
URL | http://www.dementiasplatform.uk/ |
Title | Dopamine neuron microfluidics |
Description | Development of stem cell-derived neuronal culture techniques using microfluidic devices to channel axonal growth. |
Type Of Material | Model of mechanisms or symptoms - in vitro |
Provided To Others? | No |
Impact | Not yet: it is ongoing development |
Title | High content, high throughput analysis |
Description | The ability to perform detailed high-throughput analysis of neurons in culture |
Type Of Material | Technology assay or reagent |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | Shared use of best practice in high-throughput analysis using Opera Phenix imager and high-throughout plate readers |
Title | Imaging network protocols |
Description | The DPUK molecular and structural imaging network has been awarded a MRC partnership grant and an ARUK project grant t develop standardised image acquisition and pre-processing protocols for brain imaging. |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | TO BE CONFIRMED |
Title | In vitro electrophysiology |
Description | Patch-clamp techniques to measure neuronal activity of stem cell-derived neurons |
Type Of Material | Technology assay or reagent |
Provided To Others? | No |
Impact | Analaysis of stem cell-derived neurons: dopamine neurons, cortical neurons, motor neurons and medium spiny neurons |
Title | Live cell imaging techniques in iPS-derived DA neurons in vitro |
Description | We have optimised a live cell imaging protocol for the visualisation and measurement of mitochondrial membrane potential in differentiated neurons. |
Type Of Material | Cell line |
Provided To Others? | No |
Impact | The membrane potential-sensing dye TMRM can be used to quantify membrane potential, with increased fluorescence indicating increased membrane potential. |
Title | Microglia differentiation |
Description | The ability to generate microglia from human stem cells from dementia patients |
Type Of Material | Cell line |
Provided To Others? | No |
Impact | We will be able to compare the function of microglia generated from patients and from controls |
Title | PLA in stem cell neurons |
Description | To enable the detection of a-syn oligomers in stem cell-derived dopamine neurons |
Type Of Material | Technology assay or reagent |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | The detection of a-syn oligomers in stem cell-derived dopamine neurons |
Title | RNA-Seq |
Description | Development of methods for analysis of RNA-Seq |
Type Of Material | Technology assay or reagent |
Provided To Others? | No |
Impact | Understanding of gene expression profiles in selected cell population |
Title | Stem cell network protocols |
Description | The DPUK stem cell network has been awarded a MRC partnership grant to establish network activity including the development of standard protocols for developing specific tissue types relevant to dementia research. |
Type Of Material | Physiological assessment or outcome measure |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | TO BE CONFIRMED |
Title | Target discovery assays |
Description | Develop target discovery assays using high throughput screens |
Type Of Material | Technology assay or reagent |
Provided To Others? | No |
Impact | New research facilty built for our work |
Title | WP13 Agreed Standards for Collection, Classification & Storage of Brain Tissue |
Description | This report relates to Dementias Platform UK (DPUK) Objective 3 of Work Package 13: Brain Donation. Specifically, objective 3 is to develop agreed standards for the collection, classification and storage of brains tissue. Harmonisation of procedures across brain banks enables i) comparable standards of quality and diagnostic categorisation to be employed, ii) implementation of comparable sampling, preparation and storage techniques and iii) provision of consistent key tissue quality and pathology data. Consistent with the diversity of researcher requests, it is also necessary to preserve a sufficient degree of operational flexibility in accordance with the nature of the disease and user demand. In such instances, a rationale and explanation of any differences can be provided, or where appropriate, a view presented as to when convergence might be achieved in the future. The policies outlined below are those agreed by the 4 Medical Research Council (MRC) funded brain banks as part of a milestoned funding package and are used as a minimum protocol by all the banks in the MRC UK Brain Bank Network (UK BBN). Minimal standards for collection are presented in relation to i) Brain tissue, ii) Clinical and Neuropathological information and iii) Neuropathology (Classification & storage). |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | pending DPUK consensus meeting on brain donation strategy |
Title | WP13 Brain donation UK Brain Bank capacity and strategy for UK brain donation |
Description | 1. This report relates to DPUK Work Package 13 Objective 7: To establish a brain banking strategy based on capacity and scientific value. 2. The report presents quantitative and descriptive data relating to the current capacity and workload of 10 UK brain banks, evaluates options for extending brain donation to DPUK cohorts and makes recommendations for a longer term brain donation strategy. 3. Currently there is little spare capacity available across the UK Brain Bank Network. 4. Across the brain banks there are significant differences in the proportion of ad hoc vs registered brains collected. 5. Estimates of the number and characteristics of participants to be consented to brain donation through DPUK are required in order to predict the impact of DPUK with greater precision. 6. The availability of mortuary services is a potential bottleneck & there is a need to engage with NHS Trusts. 7. Clarification of scientific questions and identification of what DPUK seek to learn from donated brains would help to shape a brain donation strategy. 8. Conditional support for a UK Biobank brain donation pilot study. 9. A decentralised model based upon the accommodation of extra DPUK activity within existing brain bank infrastructure across the 10 brain banks is favoured. 10. The long term suitability of alternative models for consenting, centralised collection and storage warrant exploration. |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | Basis for consensus meeting on new approaches to UK brain banking. To inform a pilot study using UK Biobank and the Manchester Brain Bank. Presentation of alternative models for consenting, registration, coordination of participants and collection, processing, storage and retrieval of brain samples |
Title | WP13 Brain donation: Sample access plan. |
Description | A briefing document on access to post-mortem samples and data from the proposed DPUK collection From the discussion above decisions concerning access to DPUK samples and data need to be taken at an early stage. A number of key factors determine the framework for granting access to tissue samples, accompanying neuropathological and clinical data through a DPUK platform. These factors relate to custodianship, ethical approval, eligibility for access, the application process and the conditions of access. Following specific DPUK guidance in relation to each of these factors, subsequent actions in defining a sample access plan include the development of 1) a standard operating procedure, 2) principles of access, 3) a common request application form, 4) an application process and 5) conditions of access. While a dual approach to access implies that established brain bank and cohorts procedures will cover many aspects of the request process, the section below highlights those elements requiring unique consideration in relation to DPUK generated applications. It will be particularly important to establish a researcher FAQs to guide applicants though the process and help requesters to determine suitability of data and eligibility to gain access. |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | pending DPUK consensus meeting on brain donation strategy |
Title | Alzhemer's Disease Polygenic Risk Profiling |
Description | This model used data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained from the International Genomics of Alzheimer's Project (IGAP). Alzheimer's disease (AD) Polygenic risk scores were generated for 3177 cases and 7277 controls (GERAD data) and tested whether the alleles identified to associate with disease in IGAP sample are significantly enriched in the cases relative to the controls in the GERAD sample. The disease prediction accuracy was investigated in a sample of 3049 cases and 1554 controls (for whom APOE genotype data was available) by means of sensitivity, specificity, area under the receiver operating characteristic curve (AUC) and positive and negative predictive values. The best prediction accuracy AUC = 78.2% (95% confidence interval 77-80%) was achieved by a logistic regression model with APOE, the polygenic score, sex and age as predictors. |
Type Of Material | Computer model/algorithm |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | This approach is used to create SNP arrays for AD prediction (for research only so far). |
Title | Cerebrovascular Diseases Image Databank |
Description | Cerebrovascular Diseases Image Databank contains brain magnetic resonance & computed tomographic imaging data from patients with cerebrovascular diseases, created by Professor Joanna Wardlaw. |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
Impact | Publicly accessible data-bank, improving research results across study groups focused on developing prevention and treatment methods for small vessel diseases, stroke and Alzheimer's disease. |
URL | https://www.ed.ac.uk/clinical-sciences/edinburgh-imaging/research/themes-and-topics/analysis-and-pro... |
Title | DPUK Genomics portal |
Description | The DPUK Genetics portal provides a collaborative platform for individuals, DPUK cohorts and the wider research community to share and access research outputs from genetic research. The platform provides two key tools for finding, sharing and analysing genetic data; The Results Registry tool, accessible via the main DPUK web portal, allows searching and uploading of genetic results data. This tool provides a rich set of search tools specific to genetic data and includes visualisation using the popular JBrowse genomic browser. This tool will allow users to share this data. This can be done under secure data transfer agreements if necessary. The second tool is the Genetic Data Browser this is available exclusively within the secure DPUK infrastructure. This will allow users to create cross-cohort comparison studies based on genotypic datasets and linked phenotypic data. This tool provides an interactive dashboard which can pull in phenotypic data and genetic markers from GWAS data and allow users to intuitively explore, combine and export patient cohorts. |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Impact | The DPUK Genetics portal, housed on the DPUK platform, allows non bioinformatic-expert users to explore components of genetic data within a secure environment. We have provided access to an international consortium, GERAD, via the DPUK data portal. This is a dataset of over 18,000 cases and controls (detailed in Table 2), as well as over 5,600 samples to date submitted to the EADB, the European AD DNA bank for deciphering the missing heritability of Alzheimer's disease |
URL | https://portal.dementiasplatform.uk/ |
Title | DPUK cohorts database |
Description | collection of >30 UK cohorts available for cross-cohort analyses |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | The bringing together of data from >30 cohorts is transformative in delivering greater data access to the research community |
URL | http://www.dementiasplatform.uk/ |
Title | iPSC resource for researchers |
Description | iPSC resources available are listed on DPUK website where they can download iPSC directory provides the opportunity for researchers to formally request over 100 stem cell lines derived from healthy and diseased individuals |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Impact | Valuable way for researchers to find out about available resource |
URL | https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso... |
Description | AMYPAD |
Organisation | Amyloid Imaging to Prevent Alzheimer's Disease |
Country | European Union (EU) |
Sector | Public |
PI Contribution | JMS is UCL lead for AMYPAD at UCL - which has interdependencies with DPUK through EPAD |
Collaborator Contribution | Design of protocols |
Impact | Project recently commenced |
Start Year | 2016 |
Description | Abeta functional assays |
Organisation | University of Oxford |
Department | Department of Psychiatry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have worked to develop improved in vitro analysis odf Abeta function |
Collaborator Contribution | Collaborative development of assay |
Impact | Ongoing collaboration |
Start Year | 2015 |
Description | Collaboration with Eisai AiM Institute |
Organisation | Eisai Ltd |
Department | Eisai Inc |
Country | United States |
Sector | Private |
PI Contribution | Consultancy on Polygenic risk score for clinical trials |
Collaborator Contribution | We are in the process of negotiations |
Impact | potentially this collaboration will pay for a time of a postdoctoral researcher |
Start Year | 2018 |
Description | Collaboration with Oxford Drug Discovery Institute (ODDI) |
Organisation | University of Oxford |
Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | In the collaboration with the Oxford Drug Discovery Institute (ODDI) my team's role is to undertake cell and molecular biology wet lab work to better understand the interaction between HDAC4, NCOR and HDAC3 and how inhibition of HDAC4 will alter that interaction. |
Collaborator Contribution | The role of Oxford Drug Discovery Institute (ODDI) is to test the potency and activity of a range of HDAC4 inhibitors and to consider the drug like properties of new and existing inhibitors. In later stages of the project the ODDI may progress towards high throughput screening to identify novel chemistry and novel HDAC4 inhibitors. |
Impact | Collaboration initiated 2 months ago and work underway. |
Start Year | 2020 |
Description | Covid19 Neuroscience Group @7T |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New program of research into acute and chronic effects of COVID19 on the brain, including respiratory, cognitive and mental health effects Data collection of inpatients, and those recovering, from severe COVID19, and innovations in brain stem neurochemical imaging |
Collaborator Contribution | Expertise in spectroscopy and respiratory control from the brain Expertise in remote cognitive testing and normative data |
Impact | Pending publications Conference papers accepted, ISMRN, BNA |
Start Year | 2020 |
Description | Covid19 Neuroscience Group @7T |
Organisation | University of Oxford |
Department | Oxford Neuroscience |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | New program of research into acute and chronic effects of COVID19 on the brain, including respiratory, cognitive and mental health effects Data collection of inpatients, and those recovering, from severe COVID19, and innovations in brain stem neurochemical imaging |
Collaborator Contribution | Expertise in spectroscopy and respiratory control from the brain Expertise in remote cognitive testing and normative data |
Impact | Pending publications Conference papers accepted, ISMRN, BNA |
Start Year | 2020 |
Description | DPUK Analysts Expert Community |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Analysts Expert Community |
Organisation | Newcastle University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Analysts Expert Community |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Analysts Expert Community |
Organisation | University of Cambridge |
Department | MRC Biostatistics Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Analysts Expert Community |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Analysts Expert Community |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Cambridge |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Optimisation of high-content imaging protocols with Opera Phenix imager |
Collaborator Contribution | The ARUK Stem Cell Research Centre, Cambridge has standardised the use of the Opera Phenix and Nanostring Sprint instruments for QC in iPSC reprogramming and cproduction of cortical neurons. The Phenix is used for high-throughput imaging of pluripotency markers in patient-derived lines that are generated at the centre. The lab has established a method for routine characterisation of cortical neuron productions using the Nanostring digital gene expression platform. This will facilitate harmonisation of protocols between DPUK centres, and within the STEMBANCC consortium. The imaging platform has been used to develop methods for production of human microglia from iPSCs, and to study cell biology in patient iPSC-derived microglia, focussing on TREM2 mutatiosn. In collaboration with Talisman Therapeutics and AstraZeneca, assays have been established to measure protein uptake in cortical neurons by live imaging. |
Impact | Development of a strong Dementia Stem Cell Network in DPUK |
Start Year | 2016 |
Description | DPUK DSCN |
Organisation | Cardiff University |
Department | School of Biosciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Forming DPUK Dementia Stem Cell Network |
Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
Impact | Collaborations and interactions |
Start Year | 2015 |
Description | DPUK DSCN |
Organisation | University College London |
Department | Medical School |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Forming DPUK Dementia Stem Cell Network |
Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
Impact | Collaborations and interactions |
Start Year | 2015 |
Description | DPUK DSCN |
Organisation | University of Cambridge |
Department | Gurdon Institute |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Forming DPUK Dementia Stem Cell Network |
Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
Impact | Collaborations and interactions |
Start Year | 2015 |
Description | DPUK DSCN |
Organisation | University of Edinburgh |
Department | MRC Centre for Regenerative Medicine |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Forming DPUK Dementia Stem Cell Network |
Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
Impact | Collaborations and interactions |
Start Year | 2015 |
Description | DPUK DSCN |
Organisation | University of Manchester |
Department | Manchester Medical School |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Forming DPUK Dementia Stem Cell Network |
Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
Impact | Collaborations and interactions |
Start Year | 2015 |
Description | DPUK Data Discovery Tools Categorisation and Coding Programme |
Organisation | University of Oxford |
Department | Department of Psychiatry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Provide data from our cohort |
Collaborator Contribution | Create Data discovery tool |
Impact | Still ongoing |
Start Year | 2018 |
Description | DPUK Genetics Expert Community |
Organisation | Cardiff University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Providing infrastructure and contacts with academics in the expertise of Genetics. |
Collaborator Contribution | Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal. |
Impact | Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal. |
Start Year | 2014 |
Description | DPUK Imaging Consortium |
Organisation | MRC Dementias Platform UK |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Sharing of Imaging protocols and data management structures |
Collaborator Contribution | N/A |
Impact | Project recently commenced |
Start Year | 2016 |
Description | DPUK Ontologies Expert Community |
Organisation | Cardiff University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Ontologies Expert Community |
Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Ontologies Expert Community |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK Ontologies Expert Community |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2018 |
Description | DPUK industry partnership |
Organisation | Araclon Biotech |
Country | Spain |
Sector | Private |
PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
Collaborator Contribution | Expertise and technologies |
Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
Start Year | 2014 |
Description | DPUK industry partnership |
Organisation | AstraZeneca |
Department | MedImmune |
Country | United Kingdom |
Sector | Private |
PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
Collaborator Contribution | Expertise and technologies |
Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
Start Year | 2014 |
Description | DPUK industry partnership |
Organisation | GlaxoSmithKline (GSK) |
Department | Neurology and GI Centre of Excellence for Drug Discovery (CEDD) GSK |
Country | United Kingdom |
Sector | Private |
PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
Collaborator Contribution | Expertise and technologies |
Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
Start Year | 2014 |
Description | DPUK industry partnership |
Organisation | Ixico |
Country | United Kingdom |
Sector | Private |
PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
Collaborator Contribution | Expertise and technologies |
Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
Start Year | 2014 |
Description | DPUK industry partnership |
Organisation | Janssen Research & Development |
Country | Global |
Sector | Private |
PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
Collaborator Contribution | Expertise and technologies |
Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
Start Year | 2014 |
Description | DPUK industry partnership |
Organisation | SomaLogic |
Country | United States |
Sector | Private |
PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
Collaborator Contribution | Expertise and technologies |
Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
Start Year | 2014 |
Description | DSG (Data Study Group) Network |
Organisation | Alan Turing Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts. |
Collaborator Contribution | Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop |
Impact | Newly active March 2019 |
Start Year | 2019 |
Description | DSG (Data Study Group) Network |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts. |
Collaborator Contribution | Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop |
Impact | Newly active March 2019 |
Start Year | 2019 |
Description | Dementias Platform UK Stem Cell Partnership |
Organisation | MRC Dementias Platform UK |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network |
Collaborator Contribution | Members will share expertise and stem cell lines as part of DPUK Stem Cell Network |
Impact | Ongoing |
Start Year | 2016 |
Description | Dementias Platform UK Stem Cell Partnership |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network |
Collaborator Contribution | Members will share expertise and stem cell lines as part of DPUK Stem Cell Network |
Impact | Ongoing |
Start Year | 2016 |
Description | Dr Brent Ryan & Derek Narendra NIH Inherited Movement Disorders Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD |
Organisation | National Institutes of Health (NIH) |
Department | National Institute of Neurological Disorders and Stroke (NINDS) |
Country | United States |
Sector | Public |
PI Contribution | Dr Brent Ryan & Derek Narendra NIH Inherited Movement Disorders Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD. Scope: Collaboration to assess mitophagy in models of PD |
Collaborator Contribution | Dr Brent Ryan & Derek Narendra NIH Inherited Movement Disorders Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD. Scope: Collaboration to assess mitophagy in models of PD Publication: Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ. Trends Biochem Sci. 2020 Dec 12:S0968-0004(20)30278-4. doi: 10.1016/j.tibs.2020.11.007. Online ahead of print. PMID: 33323315 |
Impact | Publication: Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ. Trends Biochem Sci. 2020 Dec 12:S0968-0004(20)30278-4. doi: 10.1016/j.tibs.2020.11.007. Online ahead of print. PMID: 33323315 |
Start Year | 2020 |
Description | Dr Brent Ryan & Evandro Fang University of Oslo, Norway Scope: Assessment of mitophagy modulators in iPSC models of PD |
Organisation | University of Oslo |
Country | Norway |
Sector | Academic/University |
PI Contribution | Dr Brent Ryan collaborating with Evandro Fang University of Oslo, Norway Scope: Assessment of mitophagy modulators in iPSC models of PD Output: Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF. Int Rev Neurobiol. 2020;155:169-202. doi: 10.1016/bs.irn.2020.02.008. Epub 2020 Aug 11. PMID: 32854854 |
Collaborator Contribution | Dr Brent Ryan collaborating with Evandro Fang University of Oslo, Norway Scope: Assessment of mitophagy modulators in iPSC models of PD Output: Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF. Int Rev Neurobiol. 2020;155:169-202. doi: 10.1016/bs.irn.2020.02.008. Epub 2020 Aug 11. PMID: 32854854 |
Impact | Publication: Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF. Int Rev Neurobiol. 2020;155:169-202. doi: 10.1016/bs.irn.2020.02.008. Epub 2020 Aug 11. PMID: 32854854 |
Start Year | 2020 |
Description | Electrophysiology in iPSC neurons |
Organisation | University of Oxford |
Department | Department of Pharmacology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have worked to establish electrophysiology analysis of iPSC-derived cortical neurons |
Collaborator Contribution | Helped us to establish the technique |
Impact | Ongoing collaboration |
Start Year | 2014 |
Description | Enhancing autophagy flux in Parkinson's disease |
Organisation | AstraZeneca |
Department | Astra Zeneca |
Country | United States |
Sector | Private |
PI Contribution | OPDC test drug like molecules in cellular models of Parkinson's |
Collaborator Contribution | Astra Zeneca to provide drug-like small molecules. |
Impact | Ongoing |
Start Year | 2016 |
Description | Established collaboration with Ira Milosevic, University of Oxford Wellcome Centre for Human Genetics |
Organisation | University of Oxford |
Department | Wellcome Trust Centre for Human Genetics |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | To study synaptic vesicle recycling and STXBP6 biology in our Parkinson's models. Ira will provide the tools and expertise. |
Collaborator Contribution | The collaboration will be to study synaptic vesicle recycling and STXBP6 biology in our Parkinson's models. Ira will provide tools and expertise |
Impact | The collaboration will be to study synaptic vesicle recycling and STXBP6 biology in our Parkinson's models. Ira will provide tools and expertise |
Start Year | 2021 |
Description | European Prevention of Alzheimers disease project (EPAD) |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | DPUK is contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study |
Collaborator Contribution | European colleagues are also contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study |
Impact | Multi-disciplinary: clinicians, imagers, geneticists, statisticians, epidemiologists. |
Start Year | 2016 |
Description | GR@CE |
Organisation | Catalan Health Institute (ICS) |
Country | Spain |
Sector | Public |
PI Contribution | we analyse the genome-wide data |
Collaborator Contribution | the collaborators provided the data to us |
Impact | it is a multidisciplinary collaboration, involve clinicians, biologists and bioinformaticians |
Start Year | 2020 |
Description | GWAIS |
Organisation | University of Liege |
Country | Belgium |
Sector | Academic/University |
PI Contribution | We bring our expertise in AI and ML |
Collaborator Contribution | Collaborators bring their expertise in genetic interaction analyses. |
Impact | It is a multidisciplinary collaboration involving mathematicians, software developers and bioinformaticians |
Start Year | 2021 |
Description | Insight 46 |
Organisation | Medical Research Council (MRC) |
Department | MRC Cognition and Brain Sciences Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Collaborating with colleagues at the UCL MRC National Survey for Health and Development, Institute of Molecular Neuroscience, and Institute of Nuclear Medicine, Insight 46 is a major prospective two-time point (0, 12m) MRI, amyloid PET, clinical, biomarker and neuropsychological study of 500 members of the MRC National Survey for Health and Development 1946 birth cohort. This highly inter-disciplinary study involving UCL based epidemiologists, neurologists, imagers, clinical chemists, geneticists and statisticians aims to determine the earliest biomarker changes of AD, the contribution of genetic and life course influences on the development of late life cognitive impairment, and the optimal means of designing AD prevention studies. This >£5M project includes funding from ARUK, MRC Dementias Platform UK (WP4), Wolfson Foundation and Brain Research Trust, as well as industry contributions (~£850K, Eli Lilly). As well as coordinating the project (with Fox, Richards) I supervise a study manager, two clinical PhD students (Lane and Parker, a Wellcome Training Fellowship), and a study coordinator. The study is well underway, with >300 scaned; cross-sectional data will complete in October 2017; and longitudinal collection two years later. |
Collaborator Contribution | N/A |
Impact | N/A |
Start Year | 2014 |
Description | International Parkinson's Disease genetic Consortium (IPDGC) |
Organisation | The International Parkinson Disease Genomics Consortium |
Sector | Academic/University |
PI Contribution | New collaboration with the International Parkinson's Disease genetic Consortium (IPDGC); single-cell RNA seq studies, spatial transcriptomics, next generation pathology (i.e. developing deep learning algorithms for PD-related pathologies) |
Collaborator Contribution | New collaboration with the International Parkinson's Disease genetic Consortium (IPDGC); single-cell RNA seq studies, spatial transcriptomics, next generation pathology (i.e. developing deep learning algorithms for PD-related pathologies) |
Impact | New collaboration with the International Parkinson's Disease genetic Consortium (IPDGC); single-cell RNA seq studies, spatial transcriptomics, next generation pathology (i.e. developing deep learning algorithms for PD-related pathologies) |
Start Year | 2019 |
Description | JPND |
Organisation | JPND Research |
Country | Global |
Sector | Academic/University |
PI Contribution | Joint grant funding and projects |
Collaborator Contribution | Working with collaborative members on research activities |
Impact | no |
Start Year | 2016 |
Description | MINDMAPS |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | MINDMAPS is a DPUK-enabled project - it used our support and infrastructure in order to gain partnership and funding. |
Collaborator Contribution | The protocols for the MINDMAPS intended to evaluate three novel radioligands that are intended to quantify the regional availability of other radioligands being brought online for GMP production. 3 protocols are in place.This study has been set up as a public-private collaboration and has leveraged substantial new investment, both from the MRC and from other funders. |
Impact | Too early for significant outputs or outcomes |
Start Year | 2017 |
Description | MRC fellowship |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | advice and training on genomic data analysis |
Collaborator Contribution | A researcher, Dr. Emma Anderson, who is a highly productive junior researcher |
Impact | 1. To improve causal inference in mendelian randomization studies of dementia 2. To improve understanding of the genetic risk for dementia and trajectories of cognitive capabilities in aging 3. To identify modifiable risk factors that are related to dementia and cognitive decline |
Start Year | 2016 |
Description | NTAD new therapeutics in Alzheimer's disease |
Organisation | Alzheimer's Research UK |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | DPUK EM theme |
Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
Impact | Annual workshop |
Start Year | 2017 |
Description | NTAD new therapeutics in Alzheimer's disease |
Organisation | AstraZeneca |
Department | Astra Zeneca |
Country | United States |
Sector | Private |
PI Contribution | DPUK EM theme |
Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
Impact | Annual workshop |
Start Year | 2017 |
Description | NTAD new therapeutics in Alzheimer's disease |
Organisation | Eli Lilly & Company Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | DPUK EM theme |
Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
Impact | Annual workshop |
Start Year | 2017 |
Description | NTAD new therapeutics in Alzheimer's disease |
Organisation | Johnson & Johnson |
Department | Janssen Pharmaceuticals |
Country | United States |
Sector | Private |
PI Contribution | DPUK EM theme |
Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
Impact | Annual workshop |
Start Year | 2017 |
Description | NTAD new therapeutics in Alzheimer's disease |
Organisation | Oxford University Hospitals NHS Foundation Trust |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | DPUK EM theme |
Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
Impact | Annual workshop |
Start Year | 2017 |
Description | NTAD new therapeutics in Alzheimer's disease |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | DPUK EM theme |
Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
Impact | Annual workshop |
Start Year | 2017 |
Description | National Institutes of Health Oxford-Cambridge Scholars Programme (NIH-OxCam) for Stewart Humble |
Organisation | National Institutes of Health (NIH) |
Country | United States |
Sector | Public |
PI Contribution | NIH OxCam programme, a doctoral training programme for medical students to continue their education in biomedical research at either Oxford or Cambridge University in partnership with the National Institutes of Health (NIH) in Washington DC. (PI: Michael Ward, NIH; Co-supervisor: Wade-Martins; 01/10/16-30/09/20) Molecular mechanisms of progranulin in FTD |
Collaborator Contribution | NIH OxCam programme, a doctoral training programme for medical students to continue their education in biomedical research at either Oxford or Cambridge University in partnership with the National Institutes of Health (NIH) in Washington DC. (PI: Michael Ward, NIH; Co-supervisor: Wade-Martins; 01/10/16-30/09/20) Molecular mechanisms of progranulin in FTD |
Impact | NIH OxCam programme, a doctoral training programme for medical students to continue their education in biomedical research at either Oxford or Cambridge University in partnership with the National Institutes of Health (NIH) in Washington DC. (PI: Michael Ward, NIH; Co-supervisor: Wade-Martins; 01/10/16-30/09/20) Molecular mechanisms of progranulin in FTD |
Start Year | 2016 |
Description | ODDI Phenotypic drug discovery in Parkinson's |
Organisation | University of Oxford |
Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Collaborative drug discovery project in Parkinson's |
Collaborator Contribution | Collaborative drug discovery project in Parkinson's |
Impact | Ongoing |
Start Year | 2017 |
Description | PREVENT 7T |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Application of 7T technology to understand the effects of inherited risk of dementia |
Collaborator Contribution | Coordination of national PREVENT study of people at risk of dementia |
Impact | Pending |
Start Year | 2019 |
Description | PROTECT / CHARIOT-Pro / Cardiff DPUK |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform. |
Collaborator Contribution | DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping |
Impact | None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry |
Start Year | 2018 |
Description | PROTECT / CHARIOT-Pro / Cardiff DPUK |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform. |
Collaborator Contribution | DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping |
Impact | None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry |
Start Year | 2018 |
Description | PROTECT / CHARIOT-Pro / Cardiff DPUK |
Organisation | University of Exeter |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform. |
Collaborator Contribution | DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping |
Impact | None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry |
Start Year | 2018 |
Description | Principal Supervisor to Marta Madureira |
Organisation | University of Porto |
Country | Portugal |
Sector | Academic/University |
PI Contribution | As part of the GABBA Doctoral Program, Portugal, Professor Wade-Martins is Principal Supervisor to Marta Madureira; Co-supervisor Dr Jorge Azevedo; 01/11/18-31/12/20) |
Collaborator Contribution | Co supervisors of student |
Impact | Research project title: Regulation of lysosomal physiology by LRRK2 |
Start Year | 2018 |
Description | Synaptic Health |
Organisation | Alzheimer's Research UK |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | AstraZeneca |
Department | MedImmune |
Country | United Kingdom |
Sector | Private |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | Cardiff University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | Eli Lilly & Company Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | Janssen Biotech, Inc. |
Country | United States |
Sector | Private |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | King's College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | MRC Dementias Platform UK |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | University College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | University of Exeter |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | University of Glasgow |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | Synaptic Health |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
Start Year | 2015 |
Description | T-cell activation in Parkinson's |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Analysis of response of Parkinson's patient PBMCs to stimulation by alpha-synuclein |
Collaborator Contribution | Advice on growth and culture of PBMC and how to measure T-cell activation by ELISpot |
Impact | Collaboration is multi-disciplinary between molecular genetics (Wade-Martins lab) and our partner immunology lab. No outcomes yet. |
Start Year | 2019 |
Description | The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) |
Organisation | Alan Turing Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup |
Collaborator Contribution | Provision of resources at DPUK Datathons |
Impact | Newly established March 2019 |
Start Year | 2019 |
Description | The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) |
Organisation | University of Exeter |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup |
Collaborator Contribution | Provision of resources at DPUK Datathons |
Impact | Newly established March 2019 |
Start Year | 2019 |
Description | Twinning: Centre PD |
Organisation | University of Luxembourg |
Department | Faculty of Science, Technology and Communication |
Country | Luxembourg |
Sector | Academic/University |
PI Contribution | OPDC will share information on clinical cohorts, stem cells and neuropathology |
Collaborator Contribution | Centre PD will share information on clinical cohorts, stem cells and neuropathology Centre PD worked with us on the EU Twinning grant to facilitate OPDC clinical data base move from Open Clinica to Red Cap System |
Impact | Ongoing |
Start Year | 2015 |
Description | UK Dementia Platform (DPUK) |
Organisation | Medical Research Council (MRC) |
Country | United Kingdom |
Sector | Public |
PI Contribution | Many OPDC members play a leading role in the DPUK. Richard Wade-Martins head the DPUK National Dementia Stem Cell Network, Simon Lovestone heads Informatics component and Clare MacKay leads on informatics analysis of imaging. Richard and Simon are on thr DPUK Executive Committee. |
Collaborator Contribution | The MRC Dementias Platform UK (DPUK) is a £53M public-private partnership, developed and led by the Medical Research Council, to accelerate progress in, and open up, dementias research. The DPUK's aims are early detection, improved treatment and ultimately, prevention, of dementias. |
Impact | The DPUK launched in Autumn 2014. It is directed by Dr John Gallacher at the University of Cardiff, together with an executive team of investigators drawn from seven universities (Cambridge, Edinburgh, Imperial College London (ICL), Oxford, Newcastle, University College London (UCL) and Swansea), including the UCL-based MRC Unit for Lifelong Health and Ageing. The clinical research infrastructure award links DPUK with further universities, Manchester and Bristol. |
Start Year | 2014 |
Description | WIN MRI group for imaging mice Natalie Connor-Robson |
Organisation | Wellcome Trust |
Department | Wellcome Trust Cente for Neuroimaging |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | WIN MRI group for imaging mice Natalie Connor-Robson |
Collaborator Contribution | WIN MRI group for imaging mice Natalie Connor-Robson |
Impact | WIN MRI group for imaging mice Natalie Connor-Robson |
Start Year | 2019 |
Title | Biomarker evaluation of 7T MRI in dementia |
Description | evaluation of novel 7T MRI for early detection of pathology in AD, and other dementias, building on the JPND consortium "EUFIND" |
Type | Diagnostic Tool - Imaging |
Current Stage Of Development | Early clinical assessment |
Year Development Stage Completed | 2020 |
Development Status | Under active development/distribution |
Impact | stronger links to basic cognitive neurosciences of memory systems, and to multi-centre clinical transnational centres across EU |
Title | Dementia's Platform UK Biostatistics Tool |
Description | Bespoke analysis tool to perform the latest analyses on the largest UK datasets available. |
Type Of Technology | Software |
Year Produced | 2016 |
Impact | Product still under development / improvement following user feedback. |
Title | Dementia's Platform UK Cohort Selection Tool |
Description | Used to select cohorts of interest, and to put a research proposal to them for feedback under the DPUK research protocol. |
Type Of Technology | Webtool/Application |
Year Produced | 2016 |
Impact | Improvements ongoing to develop impacts. |
URL | http://www.dementiasplatform.uk/cohort-tools/ |
Title | Dementias Platform UK Data Portal |
Description | The DPUK Data Portal is a platform to allow the ingress of data from cohort studies and real-world evidence data from across the UK and internationally. The Portal allows access, subject to data provider approval, to said data via an integrated application system, and provides an analysis environment on remote desktop to allow distributed team science from anywhere in the world. The Portal environment comprises of front end user tools, a virtual desktop infrastructure for data analysis, a security system for permissions management and data upload, and an underlying architecture of substantial storage and applications to support the data needs. |
Type Of Technology | Webtool/Application |
Year Produced | 2017 |
Impact | To date (early 2019) we have had ~80 applications for cohort data via our new processes. Of these, 50 have been approved and at least 25 studies are underway with analysis of their approved cohort data. All of these studies are contributing to the dementia research community with a mixture of traditional epidemiological hypotheses, methodology validation, complex machine learning, and statistical modelling all being achieved in the Portal. Website: https://portal.dementiasplatform.uk |
Title | Digital Biomarkers for Dementia |
Description | This collaboration aims to produce smartphone and wearable focused, remote, digital biomarkers targeted at the earliest possible preclinical signs of the disease. |
Type Of Technology | Webtool/Application |
Year Produced | 2017 |
Impact | The first of the outputs from this research collaboration are currently deployed in the PREVENT and DFP trials. |
Title | POLARIS |
Description | We developed a novel approach to genetic set-based analysis and polygenic risk scoring, which accounts for linkage disequilibrium between SNPs and informs the analysis with previously reported effect sizes of a SNP's association to disease. We call this method POLARIS: POlygenic Linkage disequilibrium-Adjusted RIsk Score. |
Type Of Technology | Software |
Year Produced | 2017 |
Open Source License? | Yes |
Impact | NA |
URL | https://github.com/BakerEA/POLARIS |
Title | UKSeRP (UK Secure eResearch Platform) |
Description | UKSeRP is a secure data management and analysis platform created through MRC's capital investment in the Farr Institute. It is an integrated suite of hardware and software tools that enables uses to upload and remotely manage their data and make the data available for analysis to distributed research teams. UKSeRP instances have been created for the MRC Dementias Platform UK, UK Biobank outcome adjudication group, ALSPAC, linked Millennium Cohort Data and the Multiple Sclerosis Register. |
Type Of Technology | Webtool/Application |
Year Produced | 2014 |
Impact | UKSeRP supports the development and implementation of distributed multi-disciplinary UK Team Science in providing access to multi-modal multi-cohort data. |
Description | 26 April 2016, DPUK Annual Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | DPUK Open Day |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Conference-Programme.pdf |
Description | Participation in an activity, workshop or similar - Poster presentation at CTAD conference, Barcelona 24-27th October 2018: Child adversity |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Poster presentation: Using the power of Dementias Platform UK (DPUK) cohorts to investigate the longitudinal effects of childhood adversity on adult cognition and health outcomes: Implications for cognitive change & dementia outcomes. Interest and discussion in our research and further work which will involve further cohorts and a publication. |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.ctad-alzheimer.com/ |
Description | "The Funny Side of Parkinson's" |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | "The Funny Side of Parkinson's" on BBC1. Paul Mayhew-Archer Documentary. Richard Wade-Martins and Fahd Baig appeared to talk about OPDC. Paul was named best presenter at the Grierson Awards for this documentary. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/iplayer/episode/b072xkcz/inside-out-south-parkinsons-the-funny-side |
Description | #DementiaActionWeek2018 |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Sharing content to promote #DementiaActionWeek2018 including producing original video of researcher |
Year(s) Of Engagement Activity | 2018 |
URL | https://twitter.com/WadeMartinsLab/status/999632001920651264 |
Description | 17/06/2020 - Public Health Research at HDRUK. International Scientific Advisory Board |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Public Health Research at HDRUK. International Scientific Advisory Board, 17/06/20. |
Year(s) Of Engagement Activity | 2020 |
Description | 1946 70th birthday event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | The 70th Birthday Event celebrated the 70th birthday of participants in the MRC NSHD (1946 birth cohort) - we provided a display of brain imaging |
Year(s) Of Engagement Activity | 2016 |
Description | 2018 article published on iPS research in Oxford in Phenotype (Oxford Biochemical society magazine) |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | A decade of IPS cell research in Oxford by Sally Cowley Phenotype is the magazine of the Oxford University Biochemical Society. It is run by students and staff and published on a termly basis. |
Year(s) Of Engagement Activity | 2018 |
URL | https://issuu.com/phenotypejournal/docs/mt18 |
Description | 2018/19 OPDC Newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Study participants or study members |
Results and Impact | We produced a newsletter on OPDC activities. This was sent to all study participants, those on OPDC news mailing list and will be handed out at events. |
Year(s) Of Engagement Activity | 2018,2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/opdc2018-19-newsletter.pdf |
Description | 21/01/2021 - Data Science and Population Health Research. University of British Columbia, Canada |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Data Science and Population Health Research. University of British Columbia, Canada, 21/01/21. |
Year(s) Of Engagement Activity | 2021 |
Description | 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal. |
Year(s) Of Engagement Activity | 2015 |
Description | 28/01/2020 Big Data and Public Health. Sandra Macara BMA Memorial Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Industry/Business |
Results and Impact | PRESENTATION TO BIG DATA AND PUBLIC HEALTH, SANDRA MACARA MEMORIAL LECTURE IN CARDIFF |
Year(s) Of Engagement Activity | 2020 |
Description | 5-7 October 2016, CCNA ISAB (Vancouver)(premanifest disease & cognitive footprint?) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary lecture at Canadian consortium on Neurodegeneration and aging |
Year(s) Of Engagement Activity | 2016 |
Description | 6-7 April 2016, DZNE (Bonn)"The role of genetic cohorts in bridging clinical and basic science" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Discussion of the role of Genetic cohorts to advise the German Neurodegenerative disease research network |
Year(s) Of Engagement Activity | 2016 |
Description | A formal working group, expert panel or dialogue - DPUK Annual Conference 2018: The power of cohorts 23 April 2018 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Attended one-day conference on using DPUK platform. |
Year(s) Of Engagement Activity | 2018 |
Description | A moving target? Dementia in changing older populations (and a changing world) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A talk was given at AAIC 2016 (Alzheimer's Association International Conference) 23-28 July in Toronto, Canada. |
Year(s) Of Engagement Activity | 2016 |
Description | A population perspective on dementia and its relationship with ageing and dying across time |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Invited speaker at Brocher foundation, Geneva, 14-15 April 2016. The redefinition of Alzheimer's disease and its social and ethical consequences. |
Year(s) Of Engagement Activity | 2016 |
Description | AAIC Los Angeles Annual Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | MODEL-AD presentation - Alzheimer's Susceptibility Genes Implicate Microglial Activity |
Year(s) Of Engagement Activity | 2019 |
Description | AARP press release on Global Council on Brain Health (GCBH) report "New Report Highlights Links Between Cardiovascular and Brain Health", highlighting the links between cardiovascular and brain health, 10th February 2020 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | AARP press release on Global Council on Brain Health (GCBH) report "New Report Highlights Links Between Cardiovascular and Brain Health", highlighting the links between cardiovascular and brain health, 10th February 2020 |
Year(s) Of Engagement Activity | 2020 |
URL | https://press.aarp.org/2020-2-10-Report-Highlights-Links-Between-Cardiovascular-and-Brain-Health. |
Description | ARUK 2014 Annual Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Type Of Presentation | keynote/invited speaker |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Julie Williams took part in a debate at the 2014 ARUK conference titled: Alzheimer's disease: The relative importance of Genes and Environment The conference audience took part in the debate and positive feedback was recieved about this part of the conference. |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.alzheimersresearchuk.org/conference-programme/ |
Description | ARUK Manchester Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | The Alzheimer's Research UK Conference is the UK's largest dementia research conference and this year Alzheimer's Research UK hope to host up to 450 delegates in the Neo-Gothic surroundings of Manchester Town Hall. With no parallel sessions, this is the perfect conference to gain insight from basic researchers through to clinical colleagues. Latest insights from basic and clinical research. |
Year(s) Of Engagement Activity | 2015,2016 |
URL | http://www.dementiasplatform.uk/event/alzheimers-research-uk-conference-2016/ |
Description | ARUK Network Open Morning |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | About 150-200 people attended a morning of talks from Oxford researchers, including presentations on using stem cells in dementia research. |
Year(s) Of Engagement Activity | 2015,2016 |
Description | ARUK Oxford Drug Discovery Institute |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presenter at the ARUK Oxford Drug Discovery Institute (ODDI) Collaborators meeting |
Year(s) Of Engagement Activity | 2020 |
Description | ARUK Oxford Network Research Day presentation July 2019 - Bryan Ng |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | In July 2019, Bryan Ng attended the ARUK Oxford Network Research Day and gave a presentation |
Year(s) Of Engagement Activity | 2019 |
Description | ARUK Oxford network dementia information event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Open day of talks and information stands organised by Alzheimer's UK Oxford Research Network at John Radcliffe Hospital. Talk by Sana Suri on Brain-Heart links |
Year(s) Of Engagement Activity | 2018,2019 |
URL | https://www.oxdare.ox.ac.uk/public-events |
Description | ARUK Public Engagement open day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Public engagement |
Year(s) Of Engagement Activity | 2015 |
Description | ARUK Roundtable |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | I have been invited and participated in a Roundtable discussion organized by Alzheimer's Research UK: "Where now for Alzheimer's disease research? Learning from recent clinical trials failures and planning for the future", 19 January, 2017 |
Year(s) Of Engagement Activity | 2017 |
Description | ARUK Scientific meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other audiences |
Results and Impact | Scientific meeting |
Year(s) Of Engagement Activity | 2015 |
Description | ARUK Technical Workshop |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Collaborative workshop to discuss the technical infrastructure of data sharing platforms, including DPUK to facilitate targeted treatments and research. Outcomes have resulted in collaborative networks, invitation to join steering committee, future workshop hosting (DPUK Data Portal), co-hosting of Datathons with ARUK-Turing, collaboration on a grant application and intellectual sharing of ideas. |
Year(s) Of Engagement Activity | 2018 |
Description | ARUK conference 2015 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Participants in your research and patient groups |
Results and Impact | Lots of questions More interest in taking part in dementia research |
Year(s) Of Engagement Activity | 2015 |
Description | ARUK conference poster presentation in March 2020 - Bryan Ng - EVENT CANCELLED DUE TO CORONAVIRUS |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | ARUK conference poster presentation in March 2020 - Bryan Ng |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.alzheimersresearchuk.org/for-researchers/research-conference-2020/abstracts/ |
Description | ARUK network 2019 Exeter |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | The event was organised between the ARUK Bristol & Bath, Southwest (Exeter and Plymouth) and Wales networks. The aim was for members to meet, showcase research & build collaborations. J Williams spoke on Research infrastructure and resources: UKDRI as member of Cardiff University and UK Brain Banks Network |
Year(s) Of Engagement Activity | 2019 |
Description | ARUK scientific meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Awareness raising for DPUK and building networks. |
Year(s) Of Engagement Activity | 2016 |
Description | Alzheimer's & Parkinson's Disease Congress 2015 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | The 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PD 2015) will build on the well-earned reputation of previous AD/PD meetings for unraveling the mechanisms and improving the treatment of Alzheimer's, Parkinson's and other related neurodegenerative diseases. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=3 |
Description | Alzheimer's Association International Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | International Conference to highlight progress made and new opportunities in dementia research. AAIC attracts international investigators, clinicians and care providers gather to share the latest study results, theories and discoveries. |
Year(s) Of Engagement Activity | 2016 |
Description | Alzheimer's Association International Conference (AAIC) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Present research at AAIC, which is the largest international meeting dedicated to advancing dementia science. The purpose is to disseminate our research and to learn about current and novel research in dementia science. |
Year(s) Of Engagement Activity | 2016 |
Description | Alzheimer's Society Annual Research Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | The Dementias Platform UK: what is it and what can it do for you? The Alzheimer's Society Annual Research conference will take place on 29-30 June 2015 at the Mercure Manchester Piccadilly Hotel. The conference will bring together researchers and people affected by dementia. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=6 |
Description | Alzheimer's Society debate: How can we beat dementia in the next twenty years |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Organised by the Alzheimer's Society. this involved patients, carers, supporters and the media who have had subsequent interest in research. very positive feedback from the Alzheimer's Society who were grateful for the input. |
Year(s) Of Engagement Activity | 2016 |
Description | Alzheimer's gene study achieves landmark breakthrough |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Cardiff University publicised publication in Nature Genetics "Genetic meta-analysis of diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing" - aiming to raise public awareness of research being undertaken at UK Dementia Research Institute Cardiff |
Year(s) Of Engagement Activity | 2019 |
Description | An invited interview at the Alzheimer's Research UK (ARUK) 2019 the Video Journal of Dementia |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Media (as a channel to the public) |
Results and Impact | An interview for Video Journal of Dementia |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.vjdementia.com |
Description | An invited interview on issues facing researchers in Brexit for the Cross Party Group on Medical Research for Alzheimer's Society, UK |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Have provided an opinion on issues facing researchers in Brexit for the Cross Party Group in the Welsh Assembly looking at Medical Research |
Year(s) Of Engagement Activity | 2018 |
Description | Article in newspaper (The Times) - performance of eight-year-olds on a test of thinking skills may predict how they will perform on tests of thinking and memory skills when they are 70. |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Increased public interest and support in dementia research |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.thetimes.co.uk/article/children-who-do-puzzles-reduce-risk-of-dementia-in-later-life-z0z... |
Description | AstraZeneca drug libraries article on DPUK website |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Article on Astra Zeneca Drug library screening on DPUK website accessible in the "For Researchers" tab then "Our Research Communities" Facilitated by DPUK, scientists at the University of Oxford are investigating the behaviour of drugs developed by AstraZeneca (AZ) on patient-specific cell models. They are looking to see if they can be used to target a range of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. |
Year(s) Of Engagement Activity | 2018,2019 |
URL | https://www.dementiasplatform.uk/our-impact/repurposing-drug-libraries |
Description | Attend Parkinson's UK engagement event at St James' Palace, London |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Attend reception at St James' Palace to raise awareness for Parkinson's disease |
Year(s) Of Engagement Activity | 2018 |
Description | Attended the ARUK Oxford Network Outreach Day in March 2019 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | The 2019 Dementia Awareness Day was held at the John Radcliffe Hospital in Oxford in March 2019. The Oxford ARUK Network Centre organise this event to discuss current dementia research taking place within the network centre, which includes the University of Oxford, Oxford Brookes University and University of Reading. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.oxdare.ox.ac.uk/openday2019 |
Description | BBC Horizon - filming 2015-16 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | BBC Horizon were interested in making a programme about Alzheimer's disease with a focus on novel technology - especially imaging - for early diagnosis and trials. Several meetings were held with the produced and his team and then several days of on-site filming including following a research subject. The film is due to be shown in Spring 2016 as a one hour long programme which is likely to reach an audience of more than a million |
Year(s) Of Engagement Activity | 2015,2016 |
Description | BBC One Saturday Breakfast News - Funny Side of Parkinson's |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Richard Wade-Martins appeared on BBC One Saturday Breakfast News with Paul Mayhew-Archer to discuss our research using stem cell technology to grow and study dopamine neurons from skin cells. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/news/health-35734888 |
Description | BBC Panorama |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Prof Julie Williams Research Team were approached to be involved in a BBC documentary. The documentary followed one of our research participants and his family through everyday life with Alzheimer's disease. Field workers and laboratory staff were also filmed in their roles. The documentary was screened on BBC1 in Panorama on 2nd June 2016. |
Year(s) Of Engagement Activity | 2016 |
Description | BBC Radio Cornwall interview on British Heart Foundation vascular dementia campaign, 7th March 2020 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | BBC Radio Cornwall interview on British Heart Foundation vascular dementia campaign, 7th March 2020 |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.bbc.co.uk/programmes/p083w1v9 |
Description | BBC Wales |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | I have given an interview for BBC Wales, broadcasted 20 April 2017 |
Year(s) Of Engagement Activity | 2017 |
Description | BBC Wales Dementia Week 2016 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Filming with BBC Wales's Owain Clarke on Thursday (12th May, 10-12). Interview is part of a package he's doing for Alzheimer's Awareness Week. Owain will be asking Prof Williams about Wales's research contribution; her own specific research and; look ahead at what's next. Various excerpts were screened on BBC news throughout the week, featuring a number of different staff from the team at Cardiff. This raised awareness of our work and the profile of the team. |
Year(s) Of Engagement Activity | 2016 |
Description | BBC panorama |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC Panorama are following an EOAD participant. The initial interview was filmed by the BBC |
Year(s) Of Engagement Activity | 2016 |
Description | Big Data - next big thing: evaluation. Presentation to 1st NHS Wales Digital Health and Care Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk on the future of health informatics and 'Big Data' for the NHS. The purpose was to demonstrate what was already happening, how evaluations of numerous interventions were being carried out using multi-sectoral data linkage, how this was also supporting DiscoverY Science and the potential for these activities to grow into normal practice for the NHS and wider public services. |
Year(s) Of Engagement Activity | 2017 |
Description | Blog Article "Finding cures for vascular dementia" on the British Heart Foundation website (13 March 2020) |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Blog Article "Finding cures for vascular dementia" on the British Heart Foundation website (13 March 2020), featuring The University of Edinburgh SVD Research led by Professor Joanna Wardlaw. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.bhf.org.uk/what-we-do/news-from-the-bhf/news-archive/2020/march/finding-cures-for-vascul... |
Description | Blog by Bryan Ng on DPUK website |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Article on DPhil student Bryan Ng's project in Richard Wade-Martins' lab. Disease-in-a-dish studies open a window to a new level of detail in dementia |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.dementiasplatform.uk/blog/disease-in-a-dish-studies-open-a-window-to-a-new-level-of-deta... |
Description | Blog by Bryan Ng on DPUK website |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | A Blog was written and posted on the DPUK website on 21 April 2020 |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.dementiasplatform.uk/news-and-blogs/blog/pioneering-stem-cell-research-dementia |
Description | British NeuroPsychiatric Association Annual meeting 24th February - medalist Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Discussion of nosological challanges in Dementia |
Year(s) Of Engagement Activity | 2016,2017 |
URL | http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf |
Description | British Heart Foundation Donations Appeal feature on vascular dementia, February 2020. |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | British Heart Foundation Donations Appeal feature on vascular dementia, February 2020. |
Year(s) Of Engagement Activity | 2020 |
Description | British Neuropsychiatric Association Annual meeting 24 February - medalist lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Discussion of nosological challenges in dementia. |
Year(s) Of Engagement Activity | 2016,2017 |
URL | http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf |
Description | British Science Festival 2016 Workshops |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | We used VR tools to demonstrate the impact of dementia on people's everyday lives. These included using the experiences "A Walk Through Dementia", our citizen science game "Sea Hero Quest", some activities from out children's website, as well as hands on activities and memory games. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.britishsciencefestival.org/ |
Description | Bryan Ng attended the Alzheimer's Association International Conference and presented a poster in July 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | In July 2019, Bryan Ng attended the Alzheimer's Association International Conference and presented a poster. |
Year(s) Of Engagement Activity | 2019 |
URL | https://c-path.org/poster-presentation-at-the-2019-alzheimers-association-international-conference-j... |
Description | CSaP talk - How to stop bad data driving out the good in an age of misuse, misleadingness and misinformation |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | CSaP talk - How to stop bad data driving out the good in an age of misuse, misleadingness and misinformation 4 March 2019 Ed Humpherson is the CEO of the Office of Statistics Regulation. He gave an elegant talk about how numbers can be used poorly - The Number, misleading and too much unsignposted data. He talked about creating standards and reporting on these, how his office has interacted with government departments to call such practice out and how they have responded. He also talked about responsible media. I gained insight into how such a government function can operate to hold government to account. It highlighted the fact that this is possible to do within a (relatively) stable governmental/public domain structure but that it would be unlikely professional integrity heading for CPD. |
Year(s) Of Engagement Activity | 2019 |
Description | CURE ND Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Workshop to discuss disease models in the field of neurodegeneration, what are the most advanced models to date, how accurate are they, and what is missing in terms of modelling |
Year(s) Of Engagement Activity | 2021 |
Description | Caution when looking at cell recycling in Parkinson's |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Supporters |
Results and Impact | Media press release by Parkinson's UK highlighting that researchers at the Oxford Parkinson's Disease Centre have shown that cell recycling in Parkinson's may play a more complex role than previously thought. These new results have been published in the journal of Cell Reports. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.parkinsons.org.uk/news/caution-when-looking-cell-recycling-parkinsons |
Description | Cecilia (Heyne) Lee Pint of Science Public Engagement Talk, Oxford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Pint of Science Public Engagement Talk, Oxford, Autumn 2016 on using iPSC for modelling neurodegeneration |
Year(s) Of Engagement Activity | 2016 |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Talk led to a lot of questions and discussion - for almost an hour after the event A number of people expressed interest in taking part in research |
Year(s) Of Engagement Activity | 2014,2015 |
URL | http://www.dementiasplatform.uk/event/cheltenham-science-festival/ |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | The Festival theme 2019 was health and wellbeing, considering everything from the food we eat and our exercise regimes to cutting-edge medical research. As part of this theme, the event explored the latest breakthroughs in dementia research. The panel was asked to talk about the broad landscape in this field and its evolution in recent years, key achievements and challenges and an insight into how the diagnosis and treatment of dementia has changed and developed. J Williams talked about cutting-edge research and expertise and the exciting aspects of her own work within this area As populations have aged, dementia has become the fifth biggest cause of death worldwide. Yet despite its devastating consequences there is currently no cure. What do we know about this group of diseases, and are there things we can do to help reduce our risks and keep our brains fighting fit? Alzheimer's disease specialist Julie Williams and psychiatrist Ivan Koychev discuss the latest breakthroughs and discoveries that are helping to prevent, diagnose and treat dementia more effectively. |
Year(s) Of Engagement Activity | 2011,2019 |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Hands-on experiments, the MakerShack, our brand new Cyber Zone, heartbeat art there was much to explore on site in 2018! From stargazing, fun activity trails, family days and heated discussions in the Conversation Corner to a large animal dissection live on the Festival site, Cheltenham Science Festival offers science galore for all ages. Dr Tara Caffrey took part in the day to talk about her research into Tau. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.cheltenhamfestivals.com/science |
Description | Cheltenham Science Festival (in partnership with Alzheimer's Re-search UK) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Sponsored event - How your life affects your brain. Can the way you live reduce your chance of developing Alzheimer's? By monitoring groups of people over their lifetimes, and with genetic data, brain scans and medi-cal histories researchers are building as complete a pic-ture as possible of how dementia develops. John Gallacher and Nick Fox join us to show how these stud-ies can uncover the risks involved in developing forms of dementia, and how they can be avoided. |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=6 |
Description | Co-organised Synaptic Health Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | A 2 day workshop for the Synaptic Health experimental medicine work package. Attendees were academics and industry scientists involved in the workpackage or who are interested in collaborating. Outcomes were decision to write a number of collaborative research proposals to obtain research funding. |
Year(s) Of Engagement Activity | 2017 |
Description | Comment on the Polygenic Hazard scores for AD study by Tan et al (2019), Brain 142; 460-470 for Alzforum |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | I have commented on a study which was covered on Alzforum about polygenic hazard scores for AD, and shared my opinion on their availability to the public. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.alzforum.org/news/research-news/multi-gene-score-predicts-cognitive-decline-independentl... |
Description | Competent Authorities for Medical Devices Meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Discussion to influence policy and practice relating to medical devices. |
Year(s) Of Engagement Activity | 2016 |
Description | Contemporary populations and dementia, what have we learnt and where are we headed |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A talk was given at Fourth Annual NHMRC National Institute for Dementia Research Australian Disease Forum 2019 at Hobart, Tasmania Keynote Address: Contemporary populations and dementia, what have we learnt and where are we headed? |
Year(s) Of Engagement Activity | 2019 |
Description | Creation of wademartinslab_oxford instgram account |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Account for Wade-Martins lab for Molecular Neurodegeneration, University of Oxford to share news |
Year(s) Of Engagement Activity | 2018,2019 |
URL | https://www.instagram.com/wademartinslab_oxford/ |
Description | DPUK Annual Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | DPUK's annual scientific conference 2017 is open to researchers, funders, government, charities and the public. The keynote speaker will be Monique Breteler. The focus of the day will be on demonstrating tools, presenting data on outcomes to date, and showcasing the complementarity of the Dementia Resource Institute and Dementias Platform UK. This will be the fourth DPUK conference. |
Year(s) Of Engagement Activity | 2014,2015,2016,2017 |
URL | http://www.dementiasplatform.uk/event/dementias-platform-uk-annual-conference-2016/ |
Description | DPUK Cohort Engagement Seminar |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | The purpose of the Cohort Seminar is to provide an overview of the Dementias Platform UK, build relationships with cohorts and formally invite cohorts to be part of DPUK. |
Year(s) Of Engagement Activity | 2015,2016 |
URL | http://www.dementiasplatform.uk/events/?yy=2016&mm=1 |
Description | DPUK Exeter Datathon |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | DPUK Exeter Datathon held at the University of Exeter. 22 researchers convened to focus on machine learning and AI from two cohort datasets (ELSA, NACC), and used the DPUK Data Portal datathon virtual desktop to investigate this data and test methodology. |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.exeter.ac.uk/news/events/details/index.php?event=9294 |
Description | DPUK Newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | The DPUK newsletter is issued three times a year. It regularly includes updates from the Director, notifications of the conference and other events, news on project successes, and information on collaborative activity and any awards available. Through the newsletter, there is increased engagement from the project's target audiences with DPUK's work and events. |
Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019 |
Description | DPUK Stakeholders Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Raised awareness of use of stem cells in dementia research |
Year(s) Of Engagement Activity | 2015 |
Description | DPUK Swansea Datathon |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | DPUK Swansea Datathon held at Swansea University - October 2019. 25 researchers convened to investigate the co-morbidity of dementia across 4 DPUK cohorts' data - BRACE, CaPS, ELSA, Generation Scotland. The event consisted of talks on each of the cohorts and analysis sessions to explore and investigate data across teams. Findings were reported in a final presentation session on the third day. |
Year(s) Of Engagement Activity | 2019 |
URL | https://popdatasci.swan.ac.uk/population-data-science-at-swansea-university-dpuk-datathon/ |
Description | DPUK Turing Institute Datathon |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A DPUK Datathon held at the Alan Turing Institute in London. The event comprised 42 researchers using the DPUK Data Portal datathon virtual desktop to investigate data from the Deep and Frequent Phenotyping study. The focus of the Datathon was on machine learning and artificial intelligence, and made use of phenotypic and imaging data from the DFP pilot. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.turing.ac.uk/events/innovative-data-science-alzheimers-research |
Description | DPUK UEA Datathon |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | DPUK Datathon held at University of East Anglia. 60 researchers convened to explore and investigate data from 3 DPUK cohorts (ELSA, CaPS, DFP), using the DPUK Data Portal datathon virtual desktop. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.dementiasplatform.uk/upcoming-events/dpuk-datathon-2013-uea |
Description | DPUK Website feature iPSCs: a shared resource |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Information on iPSC labs on DPUK website accessible in the "For Researchers" tab then "Our Research Communities" |
Year(s) Of Engagement Activity | 2018,2019 |
URL | https://www.dementiasplatform.uk/our-impact/ipscs-a-shared-resource |
Description | Data Linkage to Cohort Studies. Presentation to CLOSER research group, London - 3/11/14 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Data Linkage to Cohort Studies. Presentation to CLOSER research group, London |
Year(s) Of Engagement Activity | 2014 |
Description | Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff - 27/11/16 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff |
Year(s) Of Engagement Activity | 2016 |
Description | Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton - 11/10/16 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton |
Year(s) Of Engagement Activity | 2016 |
Description | Daybreak Lectures on issues around dementia |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Phillippa Carling gave a brief overview of her work on drug discovery lab at ODDI, with some videos of some of their equipment. |
Year(s) Of Engagement Activity | 2018 |
Description | Dementia Advisory Group Meeting International Health Metrics/GBD |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dementia Advisory Group Meeting International Health Metrics/GBD (funded by Gates) 19 July 2019 This was the second DAG that I have attended. The first was by phone. This was in person in Los Angeles. The programme contained updates on how the GBD team at the University of Washington are synthesising evidence on dementia and creating Global metrics. The advisory panel includes individuals with very different experiences and expertise, including health economics and those who are pure epidemiologists. This meant the discussion was very rich and stimulating, and that although we are advisors we are also learning. It provided insights into the synthesis of evidence, the approaches this team teak to doing this There was lively discussion about the challenges - with aspects ranging from sociocultural context of dementia, changes across time, evidence from different fields of non communicable diseases, how to incorporate dementia associated with other conditions that are already exercises in GBD and incorporate dementia into their own outcomes (ie. Danger of double counting). The health economics remains a crude science relative to the epidemiology and for both there is a great challenge of absence of data or data that are not population representative where they do exist. I will continue to be part of this DAG, but the discussions are relevant to work for PHE and also at the national level in my work with FPH and RCP. Continue to engage where possible with these kinds of meetings where there is much mutual learning, as expressed by one of the other attendees. |
Year(s) Of Engagement Activity | 2019 |
Description | Dementia Awareness Morning - Bryan Ng |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Bryan Ng helped out at a dementia awareness event at the John Radcliffe Hospital. This was a morning of talks about research into dementia in and around Oxford and a chance for the public to meet researchers and find out about support services available for people living with dementia. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.oxdare.ox.ac.uk/public-events |
Description | Dementia and Neurodegeneration Network Ireland (DNNI) Inaugural conference (30 November 2017) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | explore current research/future directions in the Dementia/Neurodegeneration field, effective funding models for research and the importance of interdisciplinary collaboration. |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.eventbrite.ie/e/dnni-conference-2017-tickets-37728733658# |
Description | Dementia and a Research Institute - Interview in the Sun Newspaper 5Oct15 |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Publicity to promote the fact that 5p from each carrier bag bought would be donated to the Dementia Research Centre. This was the brainchild of Malcolm Walker (Iceland) with Nick Fox (DRC) |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.thesun.co.uk/sol/homepage/woman/health/health/6735025/5p-bags-could-help-combat-dementia.... |
Description | Dementia and brain ageing in populations |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | Invited speak for Cambridge University Biological Society March 2019. Title is Dementia and brain ageing in populations. . |
Year(s) Of Engagement Activity | 2019 |
Description | Dementia: population and public health |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | A talk was given for the visit of the DRI director on 19 October 2016 at the University of Cambridge, IPH. |
Year(s) Of Engagement Activity | 2016 |
Description | Dementias Platform UK (DPUK) Scientific Symposium |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The purpose of the Symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically looking at the main themes of Cohorts, Networks and Experimental Medicine. |
Year(s) Of Engagement Activity | 2015,2016 |
Description | Dementias Platform UK (DPUK) scientific symposium |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The purpose of this symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically look at the main themes of Cohorts, Networks and Experimental Medicine |
Year(s) Of Engagement Activity | 2015,2016,2017,2018 |
Description | Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board - 15/12/15 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board, London |
Year(s) Of Engagement Activity | 2015 |
Description | Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London - 24/11/15 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London |
Year(s) Of Engagement Activity | 2015 |
Description | Dr Dayne Beccano-Kelly became an international science ambassador for the World Parkinson's Congress 2022. |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Dayne Beccano-Kelly became an international science ambassador for the World Parkinson's Congress 2022.Their focus leading up to the Congress is to help drive up participation of scientists to attend the WPC. |
Year(s) Of Engagement Activity | 2020 |
URL | https://wpc2022.org/page/2022ScienceAmb |
Description | Dr Dayne Beccano-Kelly established the Aspiring Black Physiologists award with the Physiological Society |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Schools |
Results and Impact | Dr Dayne Beccano-Kelly, along the Physiological Society established the Aspiring Black Physiologists award to address the disparity of black scientist in STEM research by encouraging black students at young ages to engage with and consider science research as a viable career path. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.physoc.org/careers/supporting-your-next-career-move/aspiring-black-physiologists/. |
Description | Dr Dayne Beccano-Kelly gave a talk at the Neurodegeneration Challenge Network (NDCN) online forum funded by the Chan Zuckerberg initiative (CZI) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | On 10th September 2020, Dr Dayne Beccano-Kelly gave a talk at the Neurodegeneration Challenge Network (NDCN) online forum funded by the Chan Zuckerberg initiative (CZI) |
Year(s) Of Engagement Activity | 2020 |
Description | Dr Dayne Beccano-Kelly gave a talk at the SelectScience Virtual Neuroscience Summit 2020 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Dayne Beccano-Kelly gave a talk at the SelectScience Virtual Neuroscience Summit 2020. The presentation tiles was 'Once upon a time at the synapse: A tale of early dysfunction in Parkinson's Disease' The presentation was recorded and featured on the Scientists' Channel: https://thescientistschannel.com/dayne-beccano-kelly |
Year(s) Of Engagement Activity | 2020 |
URL | https://neurosciencesummit2020.vfairs.com/en/#home |
Description | Dr Dayne Beccano-Kelly gave a talk on "Diversity in Teaching" to the Physiological Society as part of their webinar series |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Dayne Beccano-Kelly gave a talk on "Diversity in Teaching" by the Physiological Society He spoke about his project to make the study of physiology more appealing to BAME populations by using a competition asking participants to identify culturally appropriate role models. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.physoc.org/events/diversity-in-teaching/ |
Description | Dr Dayne Beccano-Kelly was interviewed by Parkinson's UK about Parkinson's Research and Diversity |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | In December 2020, Dr Dayne Beccano-Kelly gave an interview to Parkinson's UK about Research and Diversity |
Year(s) Of Engagement Activity | 2020 |
URL | https://medium.com/parkinsons-uk/a-researchers-view-parkinson-s-research-and-diversity-ecbee4720359 |
Description | Dr Dayne Beccano-Kelly was recognised for his contribution to science research by University of Oxford during Black History Month: |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | During Black History Month, the University highlighted the power of excellence and academic achievement, past and present, and how the contributions of Black people have contributed to the calibre of the University's reputation. Dr Dayne Beccano-Kelly was recognised for his contribution to science research by University of Oxford during Black History Month. |
Year(s) Of Engagement Activity | 2020 |
URL | https://medium.com/oxford-university/the-oxford-bhm-100-7af54c5b2764 |
Description | Dr Natalie Connor-Robson gave an online talk to the Parkinson's UK Henley Branch |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | On 24th February Dr Natalie Connor-Robson gave an outreach talk to the Henley Parkinson's UK Branch |
Year(s) Of Engagement Activity | 2021 |
Description | Dr Nora Bengoa-Vergniory & Dr Sophie Morgan gave an online presentation for the ARUK Thames Valley Network |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Due to the COVID-19 pandemic, we were unable to hold the 2020 Alzheimer's Research UK Thames Valley Network Dementia Open Morning. Over the summer presenters within the network centre who were due to talk at the March public event to give their talks online. The short talks from scientists were recorded and include a range of topics in dementia. They are available on YouTube. Sophie Morgan presentation title was 'Protein aggregation and Parkinson's disease' Nora Bengoa-Vergniory presentation title was 'Microscopic tweezers, a new avenue for treatment of neurodegenerative diseases'. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/playlist?list=PLPN7gkQCguDT-JdBjLXyTxJ_i7wCXhjYO |
Description | Dr Pavandeep Rai was a judge in an Beyond Boundaries 2020 competition |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Dr Pavandeep Rai was a judge in an Beyond Boundaries 2020 competition; an outreach event to schools in Oxfordshire. The University of Oxford invited schools to participate in an art competition for Oxfordshire state school students to create art inspired by research from Black, Asian and Minority Ethnic scientists. Students were asked to choose one of six scientists to create an artistic response to their research (e.g. painting, drawing, sculpture, animation, other artistic media) along with a short statement explaining the artwork. Due to COVID-19, there was a delay to announcing the winners. The winners are to be called in January 2021 and an exhibition of their work will take place online now. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.oxfordsparks.ox.ac.uk/content/beyond-boundaries-2020 |
Description | Dr Sally Cowley gave a talk at the Cambridge Neuro Network Chan-Zuckerburg Initiative |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | On 22 October, Dr Sally Cowley gave a talk at the Cambridge Neuro Network Chan-Zuckerburg Initiative. Title: Modelling neuroinflammation using human induced Pluripotent Stem cell-derived microglia |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.neuroscience.cam.ac.uk/news/article.php?permalink=9c3213a467 |
Description | Dr Sally Cowley gave a talk at the European Microglia Seminar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | On 2 Nivember Dr Sally Cowley gave an online talk at the European Microglia Seminar Series. Title: Modelling neuroinflammation using human induced Pluripotent Stem cell-derived microglia |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/watch?v=TM5VsEmt1Ts |
Description | Dr. Nora Bengoa-Vergniory gave a Poster tour presentation at the World Parkinson's Congress, Kyoto Japan. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr. Nora Bengoa-Vergniory gave a Poster tour presentation at the World Parkinson's Congress, Kyoto Japan. Subject: CLR01 protects dopaminergic neurons in vitro and in vivo in mouse and human models |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.worldpdcoalition.org/page/PastCongresses |
Description | Dr. Nora Bengoa-Vergniory gave a oral presentation at the Neuroscience symposium, Oxford UK (2019). |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr. Nora Bengoa-Vergniory gave a oral presentation at the Neuroscience symposium, Oxford UK (2019). |
Year(s) Of Engagement Activity | 2019 |
Description | Dr. Nora Bengoa-Vergniory gave an oral presentation at the Parkinson's Disease Gordon Research Conference Seminar, Maine USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dr. Nora Bengoa-Vergniory gave an oral presentation at the Parkinson's Disease Gordon Research Conference Seminar, Maine USA June 23 - 28, 2019 Subject: CLR01 protects dopaminergic neurons in vitro and in vivo in mouse and human models |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.grc.org/parkinson-s-disease-conference/2019/ |
Description | EPAD consortium |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Attendance at event to collaborate with partners to share progress in dementia research. |
Year(s) Of Engagement Activity | 2016 |
Description | Eisai Ltd webinar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Invited presenter at Eisai Ltd webinar |
Year(s) Of Engagement Activity | 2020 |
Description | Ethical Risk Assessment in Biomedical Big Data - Protecting privacy through design |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Protecting privacy through design |
Year(s) Of Engagement Activity | 2016 |
Description | European Brain Council Strategic Workshop (13 and 14 September 2017) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | EBC members and people working in the Value of Treatment White Paper. To explore new areas of project development for the EBC and the continuation of their Value of Treatment White Paper. |
Year(s) Of Engagement Activity | 2017 |
Description | European Medical Information Framework |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | More than 75 EMIF team members gathered in Budapest March 14-16, 2016 to not only share status updates on the ongoing work, but also discuss new joint AD/Metabolic scientific questions to be addressed using the EMIF framework. Overall, tremendous progress was shown for both research projects, with many more exciting results being underway and opportunities for further collaboration identified. In particular the overlap between AD and metabolic disorders, due to inflammation, such as in Diabetes Mellitus Type 2, has provided opportunities for shared work. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.emif.eu/news?news_news=5 |
Description | European Medical Information Framework conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research conference to demonstrate use of new tools and methods for the dementias research community. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.emif.eu/ |
Description | External talk at the ITMAT workshop on data science challenges and opportunities in Translational Medicine |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Talk to influence research on data science challenges. |
Year(s) Of Engagement Activity | 2017 |
Description | Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference - 24/8/16 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference, Swansea |
Year(s) Of Engagement Activity | 2016 |
Description | Fundraising activity during lockdown for Parkinson's UK |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | During the Covid pandemic lockdown, members of the Wade-Martins Group from the Oxford Parkinson's Disease Centre fundraised for Parkinson's UK with a variety of imaginative challenges for the national 2.6 challenge campaign. £1,197 was raised for the charity. |
Year(s) Of Engagement Activity | 2020 |
URL | http://www.dpag.ox.ac.uk/news/opdc-researchers-hit-target-for-parkinsons-uk-with-2-6-challenge |
Description | Generation Scotland Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Awareness raising for DPUK and building networks. |
Year(s) Of Engagement Activity | 2016 |
Description | Health and Care Research Wales Public Engagement talk 2016 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Institute of Psychological Medicine and Clinical Neurosciences staff at Cardiff University School of Medicine were required to attend a one hour presentation on the importance of engaging with the public in scientific research. The aim was to give staff a greater appreciation of public involvement, and the benefits of this in research. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.healthandcareresearch.gov.wales/involving-the-public-in-your-research |
Description | Health or illness, person or patient: Blurring the lines in the development of pre-symptomatic biomarkers for dementia |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Atkinson, S., 'Health or illness, person or patient: Blurring the lines in the development of pre-symptomatic biomarkers for dementia'. Invited Symposium Paper, Navigating Impasses in Bioethics: Rethinking Ill/Health 2015, Von Hügel Institute, St Edmund's College, University of Cambridge, Cambridge, UK. Audience: Public health, bioethics of public engagement and recruitment. |
Year(s) Of Engagement Activity | 2015 |
Description | Hong Kong University - international lectures |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | These numerous lectures provided DPUK in depth overview and dementia related discussions. |
Year(s) Of Engagement Activity | 2015 |
Description | I'd be OK getting the letter, I still would need to discuss it first |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Atkinson, S., et al. '"I'd be OK getting the letter, I still would need to discuss it first": Ethical considerations for recruitment from existing studies to dementias research. Poster Presentation, Alzheimer's Society Annual Conference, London, UK. Audience: Public health, bioethics of public engagement and recruitment. |
Year(s) Of Engagement Activity | 2017 |
Description | Inaugural academic conference: Tools for science |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Inaugural conference for Dementias Platform UK to engage researchers in our academic and industry partner institutions and beyond. Presentations from speakers covering all areas of the Dementia Platform and cohorts encouraged to join the platform. Engagement of early career researchers through a poster presentation competition. 37 posters were exhibited, some with interactive stands, and demonstrated the progress of work delivered through the DPUK Work Programme and Infrastructure Networks. Dr Carol Routledge discussed the opportunities available through the Dementia Discover Fund and Maria Carrillo, PhD, Chief Science Officer from Chicago gave her first impression of DPUK "The Dementias Platform UK and Alzheimer's Association have a lot of opportunity to collaborate in the future in my view and John Gallacher and his team have also agreed with that, and this is one of the reasons why we have been asked to listen in and help future thinking and brainstorm ideas that might come about with DPUK's established network." |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.dementiasplatform.uk/tools-for-science-dpuks-first-annual-conference-in-brief/ |
Description | Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London - 19/10/15 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London |
Year(s) Of Engagement Activity | 2015 |
Description | Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London - 23/11/15 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London Decision made that a Neurodevelopmental Disorders Research Network would require a data platform similar to the Dementias Research Platform UK |
Year(s) Of Engagement Activity | 2015 |
Description | Insight 46 launch facebook offices |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Policymakers/politicians |
Results and Impact | Talk sparked questions and included George Freeman MP - Minister for Life Sciences A number of members of the audience asked for further information |
Year(s) Of Engagement Activity | 2015 |
Description | Insurance United Against Dementia |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Alzheimer's Society Insurance United Against Dementia campaign dinner - aim to formally launch IUAD partners to senior figureheads from the insurance industry Used as an opportunity to thank existing IUAD partners and inspire potential partners to make a contribution. |
Year(s) Of Engagement Activity | 2019 |
Description | International Alzheimer's Disease Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Participation in international conference. This was an opportunity to share progress and updates in dementia research infrastructure with Alzheimer's Disease Research Network, SRT Ageing, & Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong Co-organized this with the Faculty of Architecture, Faculty of Social Sciences, Sau Po Centre on Ageing & SRT Science of Learning, The University of Hong Kong, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Shenzhen University (College of Life Sciences), Hong Kong Science & Technology Parks Corporation, & The Hong Kong Society of Aging Research. |
Year(s) Of Engagement Activity | 2016 |
Description | Interview given by OPDC student to the Dept of Physiology, Anatomy & Genetics, University of Oxford describing NIH-OxCam: a graduate student's journey to Oxford |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Stewart Humble talks i dpeth about his personal experience and how he came to join the Wade-Martins Lab from Louisiana State University Health Sciences Center in New Orleans as part of the National Institutes of Health Oxford-Cambridge Scholars Programme (NIH-OxCam), an accelerated, individualised doctoral training programme, to help him make the transition to a Physician-Scientist career path. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.dpag.ox.ac.uk/news/nih-oxcam-a-graduate-students-journey-to-oxford |
Description | Interview in Civil Service Fast Stream blog - How Stem Cells Can Boost Our Knowledge and Understanding of the Causes of Dementia |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | This is the third and final in a series of interviews carried out by a group of civil servants that have dedicated time to raising money and awareness for dementia via 'The Fund', a Fast Stream initiative. Alison Leishman, Home Office, interviewed Professor Wade-Martins about his research into dementia. Richard discussed OPDC and the DPUK. |
Year(s) Of Engagement Activity | 2016 |
URL | https://faststream.blog.gov.uk/2016/05/20/the-fascinating-world-of-research/ |
Description | Invited member of Polygenic Risk Scoring Expert Panel |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited member of Polygenic Risk Scoring Expert Panel for Illumina company, Batimore, USA |
Year(s) Of Engagement Activity | 2019 |
Description | Invited seminar at Icahn School of Medicine at Mount Sinai |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited seminar at Icahn School of Medicine at Mount Sinai, NY, USA |
Year(s) Of Engagement Activity | 2019 |
Description | Invited speaker at Alzheimer's Research UK conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited speaker at Alzheimer's Research UK conference, Harrogate UK |
Year(s) Of Engagement Activity | 2019 |
Description | Invited speaker to FBRI Alzheimer's Disease Workshop |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited speaker to FBRI Alzheimer's Disease Workshop, Boston, USA |
Year(s) Of Engagement Activity | 2019 |
Description | Invited to talk at the ARUK Dementia Research Day - Dr. Nora Bengoa-Vergniory |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | On 31July 2019, was invited to talk at the ARUK Dementia Research Day. Subject: CLR01 protects dopaminergic neurons in vitro and in vivo in mouse and human models |
Year(s) Of Engagement Activity | 2019 |
Description | Janssen Symposium |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Industry/Business |
Results and Impact | Discussion and collaboration with industry partners. |
Year(s) Of Engagement Activity | 2016 |
Description | Joint Programme for Neurodegenerative Disease (JPND) Scientific Advisory Board (SAB) strategic workshop on precision medicine (13 March 2017) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | The purpose of the workshop is to bring together clinicians, basic scientists and industry scientists to examine how the precision/stratified medicine concept can be applied to neurodegenerative disease research. |
Year(s) Of Engagement Activity | 2017 |
Description | Keynote invited speaker, Genetics and epigenetics of mental disorders international conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Keynote invited speaker, Genetics and epigenetics of mental disorders international conference, St Petersburg 2019. |
Year(s) Of Engagement Activity | 2019 |
Description | Keynote speaker at The University of Reading SIAM-IMA student chapter conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Undergraduate students |
Results and Impact | Keynote speaker at The University of Reading SIAM-IMA student chapter conference, Reading, UK. |
Year(s) Of Engagement Activity | 2019 |
Description | Keynote speech Sutcliffe Kerr Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Keynote speech at annual Walton Centre, Sutcliffe Kerr Lecture |
Year(s) Of Engagement Activity | 2019 |
Description | Late night event at The Science Museum |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | N/A |
Year(s) Of Engagement Activity | 2016 |
Description | Launch of the MRC UK Dementias Platform, Royal Society, London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | More than 200 people attended the conference launch. I presented as leader of the Informatics Platform Work Package in the morning and the interactive discussion with industry in the afternoon a number of contacts were made with industry colleagues with plans for follow up meetings |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.mrc.ac.uk/research/facilities/dementias-research-platform-uk/ |
Description | MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London - 6/7/16 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Policymakers/politicians |
Results and Impact | MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London |
Year(s) Of Engagement Activity | 2016 |
Description | MRC CBU Science Night - Cambridge Science Festival 2019 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Demonstrations of research studies, including VR game |
Year(s) Of Engagement Activity | 2019 |
URL | http://www.mrc-cbu.cam.ac.uk/blog/2019/01/mrc-cbu-science-night-cambridge-science-festival-2019/ |
Description | MRC CNGG/NCMH/CADR stand at the Wales Gene park's Genetics and Genomics Conference |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Representatives from the Alzheimer's Genetics Team manned a stand at the Wales Gene Park's Genetics and Genomics Conference on 22nd June, 2016. A number of individuals were interested in discussing the research environment, and how participants could help with discovery science. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.eventbrite.co.uk/e/genetics-and-genomics-for-the-3rd-generation-tickets-24871582573 |
Description | MS Society Public Event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | A presentation to members of the MS Society |
Year(s) Of Engagement Activity | 2016 |
Description | Medicine and Me: Living well with Dementia |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Giving a talk on types and diagnosis of dementia at this half day meeting. The Medicine and Me series of meetings at the RSM aim to update on important conditions and gives a direct voice to patients and their carers to air their concerns on the impact of diagnosis, investigation and management. Physicians and surgeons and indeed all healthcare professionals continue to learn from and be inspired to greater efforts by our patients to improve care. The audience at this meeting will comprise of those living with dementia, their families, carers and advocates, representing about 70% of those present; and clinicians and researchers, representing not more than 30%. Clinicians will include doctors, specialist nurses and others involved in the treatment and care of those who have this condition |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.rsm.ac.uk/events/events-listing/2015-2016/groups/public-engagement-programme/mmg01-medic... |
Description | Meetings with Insight46 donors via ARUK |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Meeting with Insight46 donors via ARUK to discuss Insight46 and dementia research. |
Year(s) Of Engagement Activity | 2016 |
Description | Melodem progress meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Participation in a progress meeting for dementia researchers. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Agenda_Melodem_30June-and-1-july-2016_v1.... |
Description | Mental Health Data Science Meeting (event part-funded by Farr Institute CIPHER) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Assessment of complex interventions using routine data |
Year(s) Of Engagement Activity | 2016 |
Description | Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods - 6/7/16 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods, Bath |
Year(s) Of Engagement Activity | 2016 |
Description | NHS Lothian Annual Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Policymakers/politicians |
Results and Impact | Clinical Research : driving efficient, innovative and effective healthcare. |
Year(s) Of Engagement Activity | 2016 |
Description | New Alzheimer's risk genes discovered in record study |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | A press release was issued highlighting the discovery of 11 new susceptibility genes for AD by the IGAP consortium. Details of these findings were published by all of the main UK news organisations. |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.cardiff.ac.uk/news/articles/new-alzheimers-risk-genes-discovered-in-record-study-11975.ht... |
Description | News article to celebrate research success in World Parkinson's Month April 2020 |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | In April 2020, a news article was published to celebrate research success in World Parkinson's Month |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.dementiasplatform.uk/news-and-blogs/news/world-parkinsons-month-frontier |
Description | News story about OPDC's Natalie Connor-Robson engagement work on widening access to STEM skills with In2scienceUK |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | OPDC Career Development Fellow Natalie Connor-Robson shares STEM career advice with students taking part in the In2scienceUK programme. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/opdc-s-natalie-connor-robson-widens-access-to-stem-skills-with-in2scienceu... |
Description | News story about a collaborative study led by the OPDC's Dr Nora Bengoa-Vergniory |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | News story about a collaborative study led by the OPDC's Dr Nora Bengoa-Vergniory that has shown that compounds known as molecular tweezers could become a promising disease modifying therapy for Parkinson's. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/tiny-brain-tweezers-could-hold-the-key-to-treat-parkinson-s |
Description | News story and video featuring the Wade-Martins lab to mark World Parkinson's Day |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | News story to mark World Parkinson's Day, featuring a video with an inside look into the Wade-Martins Laboratory. The Wade-Martins Group conducts critical research into several neurodegenerative diseases, and makes up part of the OPDC with its work into Parkinson's, with the aim to understand the molecular mechanisms of these disorders and help develop new treatments. This video is narrated by Professor Richard Wade-Martins, with contributions from Charmaine Lang, Dayne Beccano-Kelly, Peter Kilfeather, Phillippa Carling, Gabriela Vilema Enriquez and former members of the team, Gabriele Corda, Rebecca Wallings and Marta Cherubini. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/inside-the-wade-martins-lab |
Description | News story and video highlighting an OPDC study that has uncovered a new way to target and treat the leading genetic contributor to Parkinson's |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Supporters |
Results and Impact | News story featuring a research paper that has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/opdc-study-uncovers-a-new-way-to-target-and-treat-the-leading-genetic-cont... |
Description | News story highlighting Dayne Beccano-Kelly, who shares his experience of being a black professional in academia & the wider story of race in research |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Dayne Beccano-Kelly, an electrophysiologist and Career Development Fellow in the Department of Physiology, Anatomy and Genetics, and part of the Oxford Parkinson's Disease Centre (OPDC) spoke to Parkinson's Life about his experience as a black professional working in Parkinson's research. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/opdc-researcher-shares-his-experience-of-being-a-black-professional-in-aca... |
Description | News story highlighting a new paper to report genome-wide transcriptomic RNA-Seq profiling of stem cell-derived astrocytes from people with Parkinson's & healthy controls. |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The news items highlighted a new research paper that was published to report genome-wide transcriptomic RNA-Seq profiling of stem cell-derived astrocytes from people with Parkinson's & healthy controls. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/new-opdc-research-into-the-role-of-astrocytes-in-parkinson-s-progression |
Description | News story highlighting a new study which has shown that the key protein RE1 Silencing Transcription Factor (REST) regulates the health of those neurons critically affected in Parkinson's Disease. |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A study led by University of Oxford researchers, Dr Brent Ryan and Dr Nora Bengoa-Vergniory has shown that the key protein RE1 Silencing Transcription Factor (REST) regulates the health of those neurons critically affected in Parkinson's Disease. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.opdc.ox.ac.uk/dopamine-neurons-need-a-rest-in-parkinson-s-disease |
Description | News story highlighting a study that a novel assay termed the tau-proximity ligation assay is able to recognise Alzheimer's disease before current detection methods. |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A study led by the Oxford Parkinson's Disease Centre's (OPDC) Dr Nora Bengoa-Vergniory has shown that a novel assay termed the tau-proximity ligation assay is able to recognise Alzheimer's disease before current detection methods. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.opdc.ox.ac.uk/tau-proximity-ligation-assay-reveals-extensive-previously-undetected-patho... |
Description | News story promoting that Milena Cioroch is awarded Apprentice of the Month for March 2020 |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Milena Cioroch, Research Assistant in the Wade-Martins Lab at the Oxford Parkinson's Disease Centre, was awarded Apprentice of the Month for March 2020 by her training provider Abingdon and Witney College. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/milena-cioroch-is-awarded-apprentice-of-the-month-for-march-2020 |
Description | News story to highlight OPDC Career Development Fellow Dr Dayne Beccano-Kelly has been selected by The World Parkinson Coalition (WPC) to be one of eight Science Ambassadors leading up to the 6th World Parkinson Congress |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | PDC Career Development Fellow Dr Dayne Beccano-Kelly has been selected by The World Parkinson Coalition (WPC) to be one of eight Science Ambassadors leading up to the 6th World Parkinson Congress in June 2022. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/opdc-s-dayne-beccano-kelly-appointed-world-parkinson-coalition-science-amb... |
Description | News story to highlight OPDC Researchers participating in fundraising for Parkinson's UK |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | On Sunday 26 April, members of the Wade-Martins Group from the Oxford Parkinson's Disease Centre threw themselves into a variety of imaginative challenges for the national 2.6 challenge campaign to raise vital funds for Parkinson's UK. The challenge required participants to dream up an activity based around the numbers 2.6 or 26 that suits their skills and complete it on Sunday 26 April - when the 40th London Marathon would have taken place. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.dpag.ox.ac.uk/news/opdc-researchers-hit-target-for-parkinsons-uk-with-2-6-challenge |
Description | Nora Bengoa-Vergniory article on Celgene Fellowship |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Interviwe with Dr Nora Bengoa-Vergniory on her experience as a Celgene Fellow for the Oxford University Medical Sciences division website |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.medsci.ox.ac.uk/research/internal/funding-directory/oxford-celgene-fellowship/oxford-cel... |
Description | November 2016, WISH Summit (Qatar) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | - |
Year(s) Of Engagement Activity | 2016 |
Description | OPDC 11 July 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 11 July 2019, Austen Milnerwood, The Neuro, McGill University, gave a talk on 'The Quest for Neuroprotection in Parkinson's disease: reversing synaptic dysfunction'. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
Description | OPDC Newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Study participants or study members |
Results and Impact | In Septmeber 2019, the OPDC Autumn Newsletter was printed and published online. It included updates on:- our cohort studies from our cohort director Michele Hu, our work using smartphones to monitor Parkinson's progression. a key protein in Parkinson's which is showing promise for drug discovery understanding the genetics of Parkinson's the World Parkinson's Congress, Kyoto. The newsletter also includes a a poem by Maggie Lines and branch news from Parkinson's UK Milton Keynes. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/issue-10-autumn-newsletter-2019.pdf |
Description | OPDC Open Day 2016 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Study participants or study members |
Results and Impact | OPDC Open Day 2016 250 OPDC study Participants and Partners registered for event. Day of talks from Michele Hu, Fahd Baig, Claudio Ruffmann, Tom Barber and Richard Wade-Martins. Discussion of what participants would like from study. Talks filmed and podcasts added to website |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.opdc.ox.ac.uk/openday2016 |
Description | OPDC Open Day talks online |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Study participants or study members |
Results and Impact | A series of talks recorded at the 2018 OPDC Particpant's day are available to view on our YouTube channel and on our website. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.opdc.ox.ac.uk/videos |
Description | OPDC Research Day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other audiences |
Results and Impact | We held a research day to present an update on current Parkinson's research in the region and invited members of our SAB from overseas to present their work. This was attended by researchers from accross Oxford as well as members of the local Parkinon's UK group and interested study participants. We invited Hazel Stanyon, a study partiicpants who apoke about her experiences of how exercise has helped her Parkinson's symptoms and shared a poem. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.opdc.ox.ac.uk/research2018 |
Description | OPDC Seminar 12 November 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 12 November 2019, Evrando Fei Fang, University of Oslo, gave a talk on 'NAD+ and Mitophagy in Brain Ageing and Neurodegenerative Disorders'. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
Description | OPDC Seminar 13 November |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 13 November, Jerome Baufreton, Laboratory of Synaptic and Cellular Dynamics of Neuronal Networks, The Neuroscience Institute at Bordeaux, gave a talk on the 'Synaptic alterations in the indirect-pathway of the basal ganglia in experimental Parkinsonism |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
Description | OPDC Seminar 15 October |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 15 October, Paolo Calabresi, University of Perugia, Italy, gave a talk on the 'Striatal synaptic dysfunction in Parkinson's disease'. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
Description | OPDC Seminar 16 July 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 16 July 2019, Esther Sammler, University of Dundee gave a talk on 'Interrogating LRRK2 kinase pathway in human bio-samples in Parkinson's disease'. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
Description | OPDC Seminar 20 January 2020 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On behalf of Professor Richard Wade-Martins, Dr Matthew LaVoie gave a talk on 'Proteostasis and Mitochondrial Pathways in the Pathogenesis and Treatment of Parkinson's Disease on Monday 20 January 2020 |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
Description | OPDC Seminar 26 January 2021 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | On 26th January 2021, Dr Wilma van de Berg gave an OPDC emianr talk titled, ' Tales from the human brain: a multi scale approach to elucidate pathogenic mechanisms involved in Parkinson's'. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.opdc.ox.ac.uk/seminars-events |
Description | OPDC Seminar 28 October 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 28 October 2019, Ellen Sidransky, National Human Genome Research Institute, NIH, gave a talk on 'The magic in the web of it: How a rare disorder is helping to untangle the mysteries of Parkinson's disease'. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
Description | OPDC Seminar 3 February 2020 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On behalf of Professor Richard Wade-Martins, Dr Michael Ward, National Institute of Neurological Disorders and Stroke, gave a talk on 'Combining iPSCs and 'omics to identify molecular convergence in neurodegenerative disorders' on Monday 3 February 2020. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
Description | OPDC Seminar 8 February 2021 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | On *th February 2021, Emmanouil Metzakopian gave an OPDC Seminar talk titled 'CRISPR Cas9 genetic screens to ameliorate cellular stress in neurodegeneration'. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.opdc.ox.ac.uk/seminars-events |
Description | OPDC Seminar 9 March 2020 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On behalf of of Professor Richard Wade-Martins, Dr Hélène Plun-Favreau, UCL Institute of Neurology gave a talk on Mitophagy: from genetics to biology, and back on 9 March |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
Description | OPDC Seminar April 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 16 April 2019, Darren Moore, Center for Neurodegenerative Science, Van Andel Research Institute, gave a talk on the 'Pathway to Parkinson's Disease: A Tale of Two Genes'. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
Description | OPDC Seminar April 2020 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 20 April, Professor Daniel Otzen. Interdisciplinary Nanoscience Center (iNANO), Aarhus University will give a talk on the 'Targeting cytotoxic alpha-synuclein oligomers in Parkinson's Disease'. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.opdc.ox.ac.uk/professor-daniel-otzen-20-04-20 |
Description | OPDC Seminar June 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | On 12 June 2019, Sonia Gandhi, UCL Queen Square Institute of Neurology, gave a a talk on 'The toxic consequences of protein aggregation in Parkinson's disease'. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |