UK Dementias Platform
Lead Research Organisation:
Cardiff University
Department Name: School of Medicine
Abstract
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, bringing together data from around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of slowing it down. The platform has been funded to the level of £4.5M and invited to apply for a further £7.5M.
To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.
We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.
There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.
There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.
To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.
Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.
To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.
We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.
There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.
There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.
To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.
Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.
Technical Summary
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and cost-effective translation pipeline from basic discovery through to early phase trials (Fig 1). By combining the analytic and statistical power of >20 clinical and population cohorts representing 2M participants and creating a large readiness cohort, UKDP will create an optimal environment for basic discovery activities relevant to the clinical progression and human impact of dementia. Although UKDP is intended as a strategic and sustainable resource generating increasing scientific benefit over time, it will also deliver short and medium term benefits through the analysis of existing data, the enrichment of strategically selected cohorts, developing new ways of working with industry, and generating interest and further funding for dementias research generally.
A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.
Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.
A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.
Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.
Planned Impact
The platform will use several vehicles to deliver impact.
These were described in stage 1.
In summary:
For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
These were described in stage 1.
In summary:
For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
Organisations
- Cardiff University, United Kingdom (Collaboration, Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Janssen Research & Development (Collaboration)
- Alan Turing Institute (Collaboration)
- Newcastle University, United Kingdom (Collaboration)
- SomaLogic (Collaboration)
- Janssen Biotech, Inc. (Collaboration)
- Johnson & Johnson Ltd, United Kingdom (Collaboration)
- AstraZeneca plc (Collaboration)
- Eisai Inc (Collaboration)
- Amyloid Imaging to Prevent Alzheimer's Disease (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- Alzheimer's Research UK (Collaboration)
- Eli Lilly & Company Ltd (Collaboration)
- University of Luxembourg (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- Oxford University Hospitals NHS Trust, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- MRC Dementias Platform UK (Collaboration)
- University of Glasgow, United Kingdom (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- University of Exeter, United Kingdom (Collaboration)
- Araclon Biotech (Collaboration)
- University of Manchester, Manchester, United Kingdom (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
- Ixico (Collaboration)
- King's College London, United Kingdom (Collaboration)
Publications
Ahmad S
(2018)
Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study.
in Alzheimer's & dementia : the journal of the Alzheimer's Association
Allan CL
(2016)
Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort.
in Journal of affective disorders
Allardyce J
(2018)
Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.
in JAMA psychiatry
Anderson CS
(2019)
Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.
in Lancet (London, England)
Andreotti F
(2018)
Multichannel Sleep Stage Classification and Transfer Learning using Convolutional Neural Networks.
in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Andrews KA
(2016)
Acceleration of hippocampal atrophy rates in asymptomatic amyloidosis.
in Neurobiology of aging
Appleton JP
(2017)
Hypercholesterolaemia and vascular dementia.
in Clinical science (London, England : 1979)
Araque Caballero MÁ
(2018)
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease.
in Brain : a journal of neurology
Arba F
(2018)
Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack.
in International journal of stroke : official journal of the International Stroke Society
Arora S
(2018)
Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD.
in Neurology
| Description | ABN clinical research and academic committee, London representative |
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| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| Impact | N/A |
| Description | Alzheimer Association Educational Workshop: The basics of fluid biomarkers in AD - speaker |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| Description | Attend technical meeting on the Implementation of the Global Action Plan on Public Health Response to Dementia |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | Canadian Consortium on Neurodegeneration in Aging (CCNA) |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | Dementia Programme Board - oversee the implementation of the PM's Challenge on Dementia to 2020 |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Description | Deputy Chair, ABN Cognitive Disorders Advisory Group |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | N/A |
| Description | German Centre for Neurodegenerative Diseases (DZNE) scientific review |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | JPND SAB Meeting - re-launching its Strategic Research and Innovation Agenda (SRIA) |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | Member of Prime Minister's Research Champions Group attending G7/G8 summit |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a national consultation |
| Impact | N/A |
| Description | Member, Biobank access committee, Brains for Dementia Research |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | PCA criteria 2013-2015 |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | http://www.alzforum.org/news/conference-coverage/researchers-join-draw-posterior-cortical-atrophy-ou... |
| Description | Press conference |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | UCL ageing event - cultivating research connections across the university: organising committee and plenary speaker |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | UK representative - European Academy of Neurology Dementia Panel |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| Description | Vice Chair and Chair Elect, Advisory Council US Alzheimer's Association ISTAART |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | WHO's Global Dementia Observatory discuss the implementation of the global action plan on public health response to dementia 2017-2025 |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Description | Work group to establish a Danish brain research centre - Lundbeckfonden, The Brain Prize |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | World Dementia Council |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Participation in a advisory committee |
| Description | 1946 ARUK |
| Amount | £1,824,093 (GBP) |
| Funding ID | ARUK-PG2014-1946 |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2014 |
| End | 06/2017 |
| Description | ABN Research Fellowship (Cope) |
| Amount | £180,000 (GBP) |
| Funding ID | RG78594 |
| Organisation | Association of British Neurologists (ABN) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2015 |
| End | 11/2018 |
| Description | ARUK ODDI collaboration: Phenotypic drug discovery in Parkinson's |
| Amount | £200,000 (GBP) |
| Organisation | University of Oxford |
| Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2020 |
| Description | Additional funding from Janssen for Synaptic Plasticity work |
| Amount | £400,000 (GBP) |
| Organisation | Johnson & Johnson |
| Department | Janssen Pharmaceuticals |
| Sector | Private |
| Country | United States |
| Start | 12/2016 |
| End | 12/2017 |
| Description | Alcohol misuse: electronic longitudinal alcohol study in communities |
| Amount | £1,200,000 (GBP) |
| Funding ID | ES/L015471/1 |
| Organisation | Economic and Social Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Brain Research Trust |
| Amount | £219,355 (GBP) |
| Organisation | Brain Research Trust (BRT) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 03/2019 |
| Description | Computational Tools for Parkinson's disease Therapeutics |
| Amount | £20,000 (GBP) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2018 |
| End | 01/2019 |
| Description | Computer Simulation of LRRK2 and GBA interactions |
| Amount | $225,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2019 |
| End | 06/2020 |
| Description | Drake Foundation: Effects of head injury the NSHD 1946 birth cohort. |
| Amount | £60,852 (GBP) |
| Organisation | The Drake Foundation |
| Sector | Charity/Non Profit |
| Country | Unknown |
| Start | 04/2017 |
| End | 04/2019 |
| Description | Drake Foundation: Head Injury, cognition and imaging correlates of dementia in the Insight 46 cohort |
| Amount | £60,852 (GBP) |
| Organisation | The Drake Foundation |
| Sector | Charity/Non Profit |
| Country | Unknown |
| Start | 04/2016 |
| End | 04/2019 |
| Description | EU IMI-2. Amyloid imaging to prevent Alzheimer's disease (AMYPAD) |
| Amount | £934,500 (GBP) |
| Organisation | European Social Survey: European Research Infrastructure Consortium (ESS ERIC) |
| Sector | Charity/Non Profit |
| Country | European Union (EU) |
| Start | 10/2016 |
| End | 09/2021 |
| Description | Improving prevention trials in AD through imaging |
| Amount | £249,965 (GBP) |
| Funding ID | 261 (AS-PG-15-025) |
| Organisation | Alzheimer’s Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 02/2017 |
| Description | Investigation of T cell reactivity to alpha-synuclein in Parkinson's disease. |
| Amount | £620,000 (GBP) |
| Organisation | Celgene |
| Sector | Private |
| Country | United States |
| Start | 10/2018 |
| End | 09/2021 |
| Description | JPND |
| Amount | £350,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 05/2019 |
| Description | MJ Fox Therapeutic Pipeline Program: Enhancing autophagy flux in Parkinson's disease |
| Amount | $330,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | |
| Description | MRC Deep and Frequent Phenotyping Grant (Simon Lovestone PI, awarded 2016) |
| Amount | £6,900,000 (GBP) |
| Funding ID | MR/N029941/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | MRC Momentum Award (Microglial interactions in Alzheimer's Disease) |
| Amount | £4,300,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2017 |
| Description | MRC Momentum Award (Microglial interactions in Alzheimer's Disease-informatics) |
| Amount | £1,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | MRC Partnership Award (Dementias Platform UK Stem Cell Partnership) |
| Amount | £1,200,000 (GBP) |
| Funding ID | MR/N013255/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 07/2016 |
| End | 06/2020 |
| Description | Mental Health Pathfinder Award |
| Amount | £1,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | NTAD: new-therapeutics-in-alzheimers-disease |
| Amount | £1,200,000 (GBP) |
| Organisation | MRC Dementias Platform UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 09/2020 |
| Description | New Therapeutics in Alzheimer s Disease (NTAD) - ARUK |
| Amount | £100,000 (GBP) |
| Funding ID | RG89702 |
| Organisation | Versus Arthritis |
| Start | 10/2017 |
| End | 08/2020 |
| Description | Ordering the earliest neuronal response events |
| Amount | $150,000 (USD) |
| Funding ID | 16324 |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 01/2019 |
| End | 01/2020 |
| Description | Oxford Interdisciplinary Bioscience Doctoral Training Partnership (DTP) - Sally Cowley |
| Amount | £90,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2023 |
| Description | Oxford Parkinson's Disease Centre Discovery Cohort PBMCs for T cell reactivity study |
| Amount | £78,528 (GBP) |
| Organisation | Celgene |
| Sector | Private |
| Country | United States |
| Start | 09/2018 |
| End | 09/2019 |
| Description | ROADS IMI2 call 6 |
| Amount | € 4,000,000 (EUR) |
| Organisation | European Commission |
| Department | Innovative Medicines Initiative (IMI) |
| Sector | Multiple |
| Country | European Union (EU) |
| Start | 09/2016 |
| End | 08/2018 |
| Description | Sanofi/Genzyme: Modulating GBA activity as a Parkinson's disease therapy |
| Amount | £200,000 (GBP) |
| Organisation | Sanofi |
| Department | Genzyme Therapeutics Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 10/2017 |
| Description | The Airwave Health Monitoring Study (AHMS). An Occupational Cohort Study of the British Police Forces |
| Amount | £1,941,097 (GBP) |
| Funding ID | MR/R023484/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 04/2023 |
| Description | The development of digital biomarkers for dementia |
| Amount | £1,200,873 (GBP) |
| Organisation | Eli Lilly & Company Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 11/2022 |
| Description | UK Dementias Platform |
| Amount | £13,607,814 (GBP) |
| Funding ID | MR/L023784/2 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 06/2019 |
| Description | Uniting iPCS and CRISPR/Cas9 screens- a platform to model and interrogate genetic disease in Oxford |
| Amount | £80,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 09/2019 |
| Description | Wellcome Trust Clinical Training Fellowship |
| Amount | £174,791 (GBP) |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Bloomsbury Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2019 |
| Description | What makes strategic stroke strategic? Multimodal imaging and network methods to predict dementia after strategic stroke |
| Amount | £4,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 08/2017 |
| Title | CRISPR gene editing |
| Description | We have been able to establish CRISPR/Cas9 gene editing in our lab as a result of this project |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | We have been able to perform gene editing in iPSC lines. |
| Title | Cognitive test battery implemented in UK Biobank |
| Description | DPUK has developed a cognitive test battery suitable for use in large-scale population studies. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The battery has been deployed in the UK Biobank study |
| Title | DPUK data portal |
| Description | The DPUK secure data analysis platform for dementia research brings together over 30 UK cohorts (n=2M) for data sharing. This is a step-change in UK data sharing capacity |
| Type Of Material | Improvements to research infrastructure |
| Provided To Others? | No |
| Impact | By bringing the researcher to the data , the DPUK data portal reduces the transaction costs of data sharing at many levels. The concept has proven attractive to researchers form France, Netherlands, China, Japan, South Korea, Canada and the US and discussions are underway with these colleague to include their data within the portal. |
| URL | http://www.dementiasplatform.uk/ |
| Title | Dopamine neuron microfluidics |
| Description | Development of stem cell-derived neuronal culture techniques using microfluidic devices to channel axonal growth. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Provided To Others? | No |
| Impact | Not yet: it is ongoing development |
| Title | High content, high throughput analysis |
| Description | The ability to perform detailed high-throughput analysis of neurons in culture |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Shared use of best practice in high-throughput analysis using Opera Phenix imager and high-throughout plate readers |
| Title | Imaging network protocols |
| Description | The DPUK molecular and structural imaging network has been awarded a MRC partnership grant and an ARUK project grant t develop standardised image acquisition and pre-processing protocols for brain imaging. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | TO BE CONFIRMED |
| Title | In vitro electrophysiology |
| Description | Patch-clamp techniques to measure neuronal activity of stem cell-derived neurons |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Analaysis of stem cell-derived neurons: dopamine neurons, cortical neurons, motor neurons and medium spiny neurons |
| Title | Live cell imaging techniques in iPS-derived DA neurons in vitro |
| Description | We have optimised a live cell imaging protocol for the visualisation and measurement of mitochondrial membrane potential in differentiated neurons. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | The membrane potential-sensing dye TMRM can be used to quantify membrane potential, with increased fluorescence indicating increased membrane potential. |
| Title | Microglia differentiation |
| Description | The ability to generate microglia from human stem cells from dementia patients |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | We will be able to compare the function of microglia generated from patients and from controls |
| Title | PLA in stem cell neurons |
| Description | To enable the detection of a-syn oligomers in stem cell-derived dopamine neurons |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The detection of a-syn oligomers in stem cell-derived dopamine neurons |
| Title | RNA-Seq |
| Description | Development of methods for analysis of RNA-Seq |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Understanding of gene expression profiles in selected cell population |
| Title | Stem cell network protocols |
| Description | The DPUK stem cell network has been awarded a MRC partnership grant to establish network activity including the development of standard protocols for developing specific tissue types relevant to dementia research. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | TO BE CONFIRMED |
| Title | Target discovery assays |
| Description | Develop target discovery assays using high throughput screens |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | New research facilty built for our work |
| Title | WP13 Agreed Standards for Collection, Classification & Storage of Brain Tissue |
| Description | This report relates to Dementias Platform UK (DPUK) Objective 3 of Work Package 13: Brain Donation. Specifically, objective 3 is to develop agreed standards for the collection, classification and storage of brains tissue. Harmonisation of procedures across brain banks enables i) comparable standards of quality and diagnostic categorisation to be employed, ii) implementation of comparable sampling, preparation and storage techniques and iii) provision of consistent key tissue quality and pathology data. Consistent with the diversity of researcher requests, it is also necessary to preserve a sufficient degree of operational flexibility in accordance with the nature of the disease and user demand. In such instances, a rationale and explanation of any differences can be provided, or where appropriate, a view presented as to when convergence might be achieved in the future. The policies outlined below are those agreed by the 4 Medical Research Council (MRC) funded brain banks as part of a milestoned funding package and are used as a minimum protocol by all the banks in the MRC UK Brain Bank Network (UK BBN). Minimal standards for collection are presented in relation to i) Brain tissue, ii) Clinical and Neuropathological information and iii) Neuropathology (Classification & storage). |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | pending DPUK consensus meeting on brain donation strategy |
| Title | WP13 Brain donation UK Brain Bank capacity and strategy for UK brain donation |
| Description | 1. This report relates to DPUK Work Package 13 Objective 7: To establish a brain banking strategy based on capacity and scientific value. 2. The report presents quantitative and descriptive data relating to the current capacity and workload of 10 UK brain banks, evaluates options for extending brain donation to DPUK cohorts and makes recommendations for a longer term brain donation strategy. 3. Currently there is little spare capacity available across the UK Brain Bank Network. 4. Across the brain banks there are significant differences in the proportion of ad hoc vs registered brains collected. 5. Estimates of the number and characteristics of participants to be consented to brain donation through DPUK are required in order to predict the impact of DPUK with greater precision. 6. The availability of mortuary services is a potential bottleneck & there is a need to engage with NHS Trusts. 7. Clarification of scientific questions and identification of what DPUK seek to learn from donated brains would help to shape a brain donation strategy. 8. Conditional support for a UK Biobank brain donation pilot study. 9. A decentralised model based upon the accommodation of extra DPUK activity within existing brain bank infrastructure across the 10 brain banks is favoured. 10. The long term suitability of alternative models for consenting, centralised collection and storage warrant exploration. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Basis for consensus meeting on new approaches to UK brain banking. To inform a pilot study using UK Biobank and the Manchester Brain Bank. Presentation of alternative models for consenting, registration, coordination of participants and collection, processing, storage and retrieval of brain samples |
| Title | WP13 Brain donation: Sample access plan. |
| Description | A briefing document on access to post-mortem samples and data from the proposed DPUK collection From the discussion above decisions concerning access to DPUK samples and data need to be taken at an early stage. A number of key factors determine the framework for granting access to tissue samples, accompanying neuropathological and clinical data through a DPUK platform. These factors relate to custodianship, ethical approval, eligibility for access, the application process and the conditions of access. Following specific DPUK guidance in relation to each of these factors, subsequent actions in defining a sample access plan include the development of 1) a standard operating procedure, 2) principles of access, 3) a common request application form, 4) an application process and 5) conditions of access. While a dual approach to access implies that established brain bank and cohorts procedures will cover many aspects of the request process, the section below highlights those elements requiring unique consideration in relation to DPUK generated applications. It will be particularly important to establish a researcher FAQs to guide applicants though the process and help requesters to determine suitability of data and eligibility to gain access. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | pending DPUK consensus meeting on brain donation strategy |
| Title | Alzhemer's Disease Polygenic Risk Profiling |
| Description | This model used data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained from the International Genomics of Alzheimer's Project (IGAP). Alzheimer's disease (AD) Polygenic risk scores were generated for 3177 cases and 7277 controls (GERAD data) and tested whether the alleles identified to associate with disease in IGAP sample are significantly enriched in the cases relative to the controls in the GERAD sample. The disease prediction accuracy was investigated in a sample of 3049 cases and 1554 controls (for whom APOE genotype data was available) by means of sensitivity, specificity, area under the receiver operating characteristic curve (AUC) and positive and negative predictive values. The best prediction accuracy AUC = 78.2% (95% confidence interval 77-80%) was achieved by a logistic regression model with APOE, the polygenic score, sex and age as predictors. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | This approach is used to create SNP arrays for AD prediction (for research only so far). |
| Title | DPUK cohorts database |
| Description | collection of >30 UK cohorts available for cross-cohort analyses |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | The bringing together of data from >30 cohorts is transformative in delivering greater data access to the research community |
| URL | http://www.dementiasplatform.uk/ |
| Title | iPSC resource for researchers |
| Description | iPSC resources available are listed on DPUK website where they can download iPSC directory provides the opportunity for researchers to formally request over 100 stem cell lines derived from healthy and diseased individuals |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Valuable way for researchers to find out about available resource |
| URL | https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso... |
| Description | AMYPAD |
| Organisation | Amyloid Imaging to Prevent Alzheimer's Disease |
| Country | European Union (EU) |
| Sector | Public |
| PI Contribution | JMS is UCL lead for AMYPAD at UCL - which has interdependencies with DPUK through EPAD |
| Collaborator Contribution | Design of protocols |
| Impact | Project recently commenced |
| Start Year | 2016 |
| Description | Abeta functional assays |
| Organisation | University of Oxford |
| Department | Department of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have worked to develop improved in vitro analysis odf Abeta function |
| Collaborator Contribution | Collaborative development of assay |
| Impact | Ongoing collaboration |
| Start Year | 2015 |
| Description | Collaboration with Eisai AiM Institute |
| Organisation | Eisai Inc |
| PI Contribution | Consultancy on Polygenic risk score for clinical trials |
| Collaborator Contribution | We are in the process of negotiations |
| Impact | potentially this collaboration will pay for a time of a postdoctoral researcher |
| Start Year | 2018 |
| Description | Collaboratiuon with European Bioinformatics institute |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We plan to provide a software for polygenic risk score calculation and prosess the GWAS summary statistics for all current GWASes available in EBI GWAS catalogue |
| Collaborator Contribution | provide data access to the GWAS catalogue |
| Impact | This collaboration will provide the GWAS processed data to the research community for quick and efficient calculation of polygenic risk score for any disorder (stored in the EBI GWAS catalogue) |
| Start Year | 2019 |
| Description | DPUK Analysts Expert Community |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | Newcastle University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University of Cambridge |
| Department | MRC Biostatistics Unit |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Analysts Expert Community |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing DPUK administrative support to run collaborative meetings and leadership from the central team of scientists at DPUK. |
| Collaborator Contribution | Expertise to the discussion of analytical projects to focus on for DPUK for the future. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Optimisation of high-content imaging protocols with Opera Phenix imager |
| Collaborator Contribution | The ARUK Stem Cell Research Centre, Cambridge has standardised the use of the Opera Phenix and Nanostring Sprint instruments for QC in iPSC reprogramming and cproduction of cortical neurons. The Phenix is used for high-throughput imaging of pluripotency markers in patient-derived lines that are generated at the centre. The lab has established a method for routine characterisation of cortical neuron productions using the Nanostring digital gene expression platform. This will facilitate harmonisation of protocols between DPUK centres, and within the STEMBANCC consortium. The imaging platform has been used to develop methods for production of human microglia from iPSCs, and to study cell biology in patient iPSC-derived microglia, focussing on TREM2 mutatiosn. In collaboration with Talisman Therapeutics and AstraZeneca, assays have been established to measure protein uptake in cortical neurons by live imaging. |
| Impact | Development of a strong Dementia Stem Cell Network in DPUK |
| Start Year | 2016 |
| Description | DPUK DSCN |
| Organisation | Cardiff University |
| Department | School of Biosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University College London |
| Department | Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Cambridge |
| Department | Gurdon Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Manchester |
| Department | Manchester Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK Data Discovery Tools Categorisation and Coding Programme |
| Organisation | University of Oxford |
| Department | Department of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide data from our cohort |
| Collaborator Contribution | Create Data discovery tool |
| Impact | Still ongoing |
| Start Year | 2018 |
| Description | DPUK Genetics Expert Community |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing infrastructure and contacts with academics in the expertise of Genetics. |
| Collaborator Contribution | Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal. |
| Impact | Various suggested project initiatives and the development of the Genetics hub, linked with the DPUK Portal. |
| Start Year | 2014 |
| Description | DPUK Imaging Consortium |
| Organisation | MRC Dementias Platform UK |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Sharing of Imaging protocols and data management structures |
| Collaborator Contribution | N/A |
| Impact | Project recently commenced |
| Start Year | 2016 |
| Description | DPUK Ontologies Expert Community |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Ontologies Expert Community |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Ontologies Expert Community |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK Ontologies Expert Community |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Facilitating meetings through our administrative support and providing leadership through the scientists on our central team. |
| Collaborator Contribution | Expertise to the development of DPUK ontology discussion. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2018 |
| Description | DPUK industry partnership |
| Organisation | Araclon Biotech |
| Country | Spain |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | AstraZeneca |
| Department | AZ Medimmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Neurology and GI Centre of Excellence for Drug Discovery (CEDD) GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | Ixico |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | Janssen Research & Development |
| Country | Global |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DPUK industry partnership |
| Organisation | SomaLogic |
| Country | United States |
| Sector | Private |
| PI Contribution | The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia |
| Collaborator Contribution | Expertise and technologies |
| Impact | Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673 |
| Start Year | 2014 |
| Description | DSG (Data Study Group) Network |
| Organisation | Alan Turing Institute |
| Country | Unknown |
| Sector | Academic/University |
| PI Contribution | A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts. |
| Collaborator Contribution | Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop |
| Impact | Newly active March 2019 |
| Start Year | 2019 |
| Description | DSG (Data Study Group) Network |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts. |
| Collaborator Contribution | Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop |
| Impact | Newly active March 2019 |
| Start Year | 2019 |
| Description | Dementias Platform UK Stem Cell Partnership |
| Organisation | MRC Dementias Platform UK |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Collaborator Contribution | Members will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Impact | Ongoing |
| Start Year | 2016 |
| Description | Dementias Platform UK Stem Cell Partnership |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Collaborator Contribution | Members will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Impact | Ongoing |
| Start Year | 2016 |
| Description | Electrophysiology in iPSC neurons |
| Organisation | University of Oxford |
| Department | Department of Pharmacology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have worked to establish electrophysiology analysis of iPSC-derived cortical neurons |
| Collaborator Contribution | Helped us to establish the technique |
| Impact | Ongoing collaboration |
| Start Year | 2014 |
| Description | Enhancing autophagy flux in Parkinson's disease |
| Organisation | AstraZeneca |
| Department | Astra Zeneca |
| Country | United States |
| Sector | Private |
| PI Contribution | OPDC test drug like molecules in cellular models of Parkinson's |
| Collaborator Contribution | Astra Zeneca to provide drug-like small molecules. |
| Impact | Ongoing |
| Start Year | 2016 |
| Description | European Prevention of Alzheimers disease project (EPAD) |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | DPUK is contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study |
| Collaborator Contribution | European colleagues are also contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study |
| Impact | Multi-disciplinary: clinicians, imagers, geneticists, statisticians, epidemiologists. |
| Start Year | 2016 |
| Description | Insight 46 |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Cognition and Brain Sciences Unit |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Collaborating with colleagues at the UCL MRC National Survey for Health and Development, Institute of Molecular Neuroscience, and Institute of Nuclear Medicine, Insight 46 is a major prospective two-time point (0, 12m) MRI, amyloid PET, clinical, biomarker and neuropsychological study of 500 members of the MRC National Survey for Health and Development 1946 birth cohort. This highly inter-disciplinary study involving UCL based epidemiologists, neurologists, imagers, clinical chemists, geneticists and statisticians aims to determine the earliest biomarker changes of AD, the contribution of genetic and life course influences on the development of late life cognitive impairment, and the optimal means of designing AD prevention studies. This >£5M project includes funding from ARUK, MRC Dementias Platform UK (WP4), Wolfson Foundation and Brain Research Trust, as well as industry contributions (~£850K, Eli Lilly). As well as coordinating the project (with Fox, Richards) I supervise a study manager, two clinical PhD students (Lane and Parker, a Wellcome Training Fellowship), and a study coordinator. The study is well underway, with >300 scaned; cross-sectional data will complete in October 2017; and longitudinal collection two years later. |
| Collaborator Contribution | N/A |
| Impact | N/A |
| Start Year | 2014 |
| Description | MINDMAPS |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | MINDMAPS is a DPUK-enabled project - it used our support and infrastructure in order to gain partnership and funding. |
| Collaborator Contribution | The protocols for the MINDMAPS intended to evaluate three novel radioligands that are intended to quantify the regional availability of other radioligands being brought online for GMP production. 3 protocols are in place.This study has been set up as a public-private collaboration and has leveraged substantial new investment, both from the MRC and from other funders. |
| Impact | Too early for significant outputs or outcomes |
| Start Year | 2017 |
| Description | MRC fellowship |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | advice and training on genomic data analysis |
| Collaborator Contribution | A researcher, Dr. Emma Anderson, who is a highly productive junior researcher |
| Impact | 1. To improve causal inference in mendelian randomization studies of dementia 2. To improve understanding of the genetic risk for dementia and trajectories of cognitive capabilities in aging 3. To identify modifiable risk factors that are related to dementia and cognitive decline |
| Start Year | 2016 |
| Description | NTAD new therapeutics in Alzheimer's disease |
| Organisation | Alzheimer's Research UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | DPUK EM theme |
| Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
| Impact | Annual workshop |
| Start Year | 2017 |
| Description | NTAD new therapeutics in Alzheimer's disease |
| Organisation | AstraZeneca |
| Department | Astra Zeneca |
| Country | United States |
| Sector | Private |
| PI Contribution | DPUK EM theme |
| Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
| Impact | Annual workshop |
| Start Year | 2017 |
| Description | NTAD new therapeutics in Alzheimer's disease |
| Organisation | Eli Lilly & Company Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | DPUK EM theme |
| Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
| Impact | Annual workshop |
| Start Year | 2017 |
| Description | NTAD new therapeutics in Alzheimer's disease |
| Organisation | Johnson & Johnson |
| Department | Janssen Pharmaceuticals |
| Country | United States |
| Sector | Private |
| PI Contribution | DPUK EM theme |
| Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
| Impact | Annual workshop |
| Start Year | 2017 |
| Description | NTAD new therapeutics in Alzheimer's disease |
| Organisation | Oxford University Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | DPUK EM theme |
| Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
| Impact | Annual workshop |
| Start Year | 2017 |
| Description | NTAD new therapeutics in Alzheimer's disease |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | DPUK EM theme |
| Collaborator Contribution | New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK - |
| Impact | Annual workshop |
| Start Year | 2017 |
| Description | ODDI Phenotypic drug discovery in Parkinson's |
| Organisation | University of Oxford |
| Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Collaborative drug discovery project in Parkinson's |
| Collaborator Contribution | Collaborative drug discovery project in Parkinson's |
| Impact | Ongoing |
| Start Year | 2017 |
| Description | Synaptic Health |
| Organisation | Alzheimer's Research UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | AstraZeneca |
| Department | AZ Medimmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | Eli Lilly & Company Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | Janssen Biotech, Inc. |
| Country | United States |
| Sector | Private |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | MRC Dementias Platform UK |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | Synaptic Health |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study; |
| Collaborator Contribution | Expertise in translational neuroscience; planning; meetings; application for further funding; |
| Impact | New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending; |
| Start Year | 2015 |
| Description | The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) |
| Organisation | Alan Turing Institute |
| Country | Unknown |
| Sector | Academic/University |
| PI Contribution | Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup |
| Collaborator Contribution | Provision of resources at DPUK Datathons |
| Impact | Newly established March 2019 |
| Start Year | 2019 |
| Description | The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup |
| Collaborator Contribution | Provision of resources at DPUK Datathons |
| Impact | Newly established March 2019 |
| Start Year | 2019 |
| Description | Twinning: Centre PD |
| Organisation | University of Luxembourg |
| Department | Faculty of Science, Technology and Communication |
| Country | Luxembourg |
| Sector | Academic/University |
| PI Contribution | OPDC will share information on clinical cohorts, stem cells and neuropathology |
| Collaborator Contribution | Centre PD will share information on clinical cohorts, stem cells and neuropathology Centre PD worked with us on the EU Twinning grant to facilitate OPDC clinical data base move from Open Clinica to Red Cap System |
| Impact | Ongoing |
| Start Year | 2015 |
| Description | UK Dementia Platform (DPUK) |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Many OPDC members play a leading role in the DPUK. Richard Wade-Martins head the DPUK National Dementia Stem Cell Network, Simon Lovestone heads Informatics component and Clare MacKay leads on informatics analysis of imaging. Richard and Simon are on thr DPUK Executive Committee. |
| Collaborator Contribution | The MRC Dementias Platform UK (DPUK) is a £53M public-private partnership, developed and led by the Medical Research Council, to accelerate progress in, and open up, dementias research. The DPUK's aims are early detection, improved treatment and ultimately, prevention, of dementias. |
| Impact | The DPUK launched in Autumn 2014. It is directed by Dr John Gallacher at the University of Cardiff, together with an executive team of investigators drawn from seven universities (Cambridge, Edinburgh, Imperial College London (ICL), Oxford, Newcastle, University College London (UCL) and Swansea), including the UCL-based MRC Unit for Lifelong Health and Ageing. The clinical research infrastructure award links DPUK with further universities, Manchester and Bristol. |
| Start Year | 2014 |
| Title | Dementias Platform UK Data Portal |
| Description | The DPUK Data Portal is a platform to allow the ingress of data from cohort studies and real-world evidence data from across the UK and internationally. The Portal allows access, subject to data provider approval, to said data via an integrated application system, and provides an analysis environment on remote desktop to allow distributed team science from anywhere in the world. The Portal environment comprises of front end user tools, a virtual desktop infrastructure for data analysis, a security system for permissions management and data upload, and an underlying architecture of substantial storage and applications to support the data needs. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2017 |
| Impact | To date (early 2019) we have had ~80 applications for cohort data via our new processes. Of these, 50 have been approved and at least 25 studies are underway with analysis of their approved cohort data. All of these studies are contributing to the dementia research community with a mixture of traditional epidemiological hypotheses, methodology validation, complex machine learning, and statistical modelling all being achieved in the Portal. Website: https://portal.dementiasplatform.uk |
| Title | Digital Biomarkers for Dementia |
| Description | This collaboration aims to produce smartphone and wearable focused, remote, digital biomarkers targeted at the earliest possible preclinical signs of the disease. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2017 |
| Impact | The first of the outputs from this research collaboration are currently deployed in the PREVENT and DFP trials. |
| Title | POLARIS |
| Description | We developed a novel approach to genetic set-based analysis and polygenic risk scoring, which accounts for linkage disequilibrium between SNPs and informs the analysis with previously reported effect sizes of a SNP's association to disease. We call this method POLARIS: POlygenic Linkage disequilibrium-Adjusted RIsk Score. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Open Source License? | Yes |
| Impact | NA |
| URL | https://github.com/BakerEA/POLARIS |
| Title | UKSeRP (UK Secure eResearch Platform) |
| Description | UKSeRP is a secure data management and analysis platform created through MRC's capital investment in the Farr Institute. It is an integrated suite of hardware and software tools that enables uses to upload and remotely manage their data and make the data available for analysis to distributed research teams. UKSeRP instances have been created for the MRC Dementias Platform UK, UK Biobank outcome adjudication group, ALSPAC, linked Millennium Cohort Data and the Multiple Sclerosis Register. |
| Type Of Technology | Webtool/Application |
| Year Produced | 2014 |
| Impact | UKSeRP supports the development and implementation of distributed multi-disciplinary UK Team Science in providing access to multi-modal multi-cohort data. |
| Description | 26 April 2016, DPUK Annual Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DPUK Open Day |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Conference-Programme.pdf |
| Description | Participation in an activity, workshop or similar - Poster presentation at CTAD conference, Barcelona 24-27th October 2018: Child adversity |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation: Using the power of Dementias Platform UK (DPUK) cohorts to investigate the longitudinal effects of childhood adversity on adult cognition and health outcomes: Implications for cognitive change & dementia outcomes. Interest and discussion in our research and further work which will involve further cohorts and a publication. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ctad-alzheimer.com/ |
| Description | "The Funny Side of Parkinson's" |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | "The Funny Side of Parkinson's" on BBC1. Paul Mayhew-Archer Documentary. Richard Wade-Martins and Fahd Baig appeared to talk about OPDC. Paul was named best presenter at the Grierson Awards for this documentary. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/iplayer/episode/b072xkcz/inside-out-south-parkinsons-the-funny-side |
| Description | #DementiaActionWeek2018 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Sharing content to promote #DementiaActionWeek2018 including producing original video of researcher |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/WadeMartinsLab/status/999632001920651264 |
| Description | 1946 70th birthday event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | The 70th Birthday Event celebrated the 70th birthday of participants in the MRC NSHD (1946 birth cohort) - we provided a display of brain imaging |
| Year(s) Of Engagement Activity | 2016 |
| Description | 2018 article published on iPS research in Oxford in Phenotype (Oxford Biochemical society magazine) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A decade of IPS cell research in Oxford by Sally Cowley Phenotype is the magazine of the Oxford University Biochemical Society. It is run by students and staff and published on a termly basis. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://issuu.com/phenotypejournal/docs/mt18 |
| Description | 2018/19 OPDC Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | We produced a newsletter on OPDC activities. This was sent to all study participants, those on OPDC news mailing list and will be handed out at events. |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc2018-19-newsletter.pdf |
| Description | 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 23/06/15. Privacy protecting data linkage research : a key tool in hastening translation and achieving population impact. Invited presentation McGill University, Montreal. |
| Year(s) Of Engagement Activity | 2015 |
| Description | 5-7 October 2016, CCNA ISAB (Vancouver)(premanifest disease & cognitive footprint?) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary lecture at Canadian consortium on Neurodegeneration and aging |
| Year(s) Of Engagement Activity | 2016 |
| Description | 6-7 April 2016, DZNE (Bonn)"The role of genetic cohorts in bridging clinical and basic science" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion of the role of Genetic cohorts to advise the German Neurodegenerative disease research network |
| Year(s) Of Engagement Activity | 2016 |
| Description | A moving target? Dementia in changing older populations (and a changing world) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given at AAIC 2016 (Alzheimer's Association International Conference) 23-28 July in Toronto, Canada. |
| Year(s) Of Engagement Activity | 2016 |
| Description | A population perspective on dementia and its relationship with ageing and dying across time |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speaker at Brocher foundation, Geneva, 14-15 April 2016. The redefinition of Alzheimer's disease and its social and ethical consequences. |
| Year(s) Of Engagement Activity | 2016 |
| Description | ARUK Manchester Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The Alzheimer's Research UK Conference is the UK's largest dementia research conference and this year Alzheimer's Research UK hope to host up to 450 delegates in the Neo-Gothic surroundings of Manchester Town Hall. With no parallel sessions, this is the perfect conference to gain insight from basic researchers through to clinical colleagues. Latest insights from basic and clinical research. |
| Year(s) Of Engagement Activity | 2015,2016 |
| URL | http://www.dementiasplatform.uk/event/alzheimers-research-uk-conference-2016/ |
| Description | ARUK Network Open Morning |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | About 150-200 people attended a morning of talks from Oxford researchers, including presentations on using stem cells in dementia research. |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | ARUK Oxford network dementia information event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Open day of talks and information stands organised by Alzheimer's UK Oxford Research Network at John Radcliffe Hospital. Talk by Sana Suri on Brain-Heart links |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.oxdare.ox.ac.uk/public-events |
| Description | ARUK Roundtable |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I have been invited and participated in a Roundtable discussion organized by Alzheimer's Research UK: "Where now for Alzheimer's disease research? Learning from recent clinical trials failures and planning for the future", 19 January, 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | ARUK Technical Workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Collaborative workshop to discuss the technical infrastructure of data sharing platforms, including DPUK to facilitate targeted treatments and research. Outcomes have resulted in collaborative networks, invitation to join steering committee, future workshop hosting (DPUK Data Portal), co-hosting of Datathons with ARUK-Turing, collaboration on a grant application and intellectual sharing of ideas. |
| Year(s) Of Engagement Activity | 2018 |
| Description | ARUK conference 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Lots of questions More interest in taking part in dementia research |
| Year(s) Of Engagement Activity | 2015 |
| Description | ARUK scientific meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Awareness raising for DPUK and building networks. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Alzheimer's & Parkinson's Disease Congress 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PD 2015) will build on the well-earned reputation of previous AD/PD meetings for unraveling the mechanisms and improving the treatment of Alzheimer's, Parkinson's and other related neurodegenerative diseases. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=3 |
| Description | Alzheimer's Association International Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International Conference to highlight progress made and new opportunities in dementia research. AAIC attracts international investigators, clinicians and care providers gather to share the latest study results, theories and discoveries. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Alzheimer's Association International Conference (AAIC) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Present research at AAIC, which is the largest international meeting dedicated to advancing dementia science. The purpose is to disseminate our research and to learn about current and novel research in dementia science. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Alzheimer's Society Annual Research Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The Dementias Platform UK: what is it and what can it do for you? The Alzheimer's Society Annual Research conference will take place on 29-30 June 2015 at the Mercure Manchester Piccadilly Hotel. The conference will bring together researchers and people affected by dementia. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=6 |
| Description | Alzheimer's Society debate: How can we beat dementia in the next twenty years |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Organised by the Alzheimer's Society. this involved patients, carers, supporters and the media who have had subsequent interest in research. very positive feedback from the Alzheimer's Society who were grateful for the input. |
| Year(s) Of Engagement Activity | 2016 |
| Description | An invited interview at the Alzheimer's Research UK (ARUK) 2019 the Video Journal of Dementia |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An interview for Video Journal of Dementia |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.vjdementia.com |
| Description | An invited interview on issues facing researchers in Brexit for the Cross Party Group on Medical Research for Alzheimer's Society, UK |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Have provided an opinion on issues facing researchers in Brexit for the Cross Party Group in the Welsh Assembly looking at Medical Research |
| Year(s) Of Engagement Activity | 2018 |
| Description | AstraZeneca drug libraries article on DPUK website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Article on Astra Zeneca Drug library screening on DPUK website accessible in the "For Researchers" tab then "Our Research Communities" Facilitated by DPUK, scientists at the University of Oxford are investigating the behaviour of drugs developed by AstraZeneca (AZ) on patient-specific cell models. They are looking to see if they can be used to target a range of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.dementiasplatform.uk/our-impact/repurposing-drug-libraries |
| Description | Attend Parkinson's UK engagement event at St James' Palace, London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Attend reception at St James' Palace to raise awareness for Parkinson's disease |
| Year(s) Of Engagement Activity | 2018 |
| Description | BBC Horizon - filming 2015-16 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC Horizon were interested in making a programme about Alzheimer's disease with a focus on novel technology - especially imaging - for early diagnosis and trials. Several meetings were held with the produced and his team and then several days of on-site filming including following a research subject. The film is due to be shown in Spring 2016 as a one hour long programme which is likely to reach an audience of more than a million |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | BBC One Saturday Breakfast News - Funny Side of Parkinson's |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Richard Wade-Martins appeared on BBC One Saturday Breakfast News with Paul Mayhew-Archer to discuss our research using stem cell technology to grow and study dopamine neurons from skin cells. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/news/health-35734888 |
| Description | BBC Wales |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | I have given an interview for BBC Wales, broadcasted 20 April 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Big Data - next big thing: evaluation. Presentation to 1st NHS Wales Digital Health and Care Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk on the future of health informatics and 'Big Data' for the NHS. The purpose was to demonstrate what was already happening, how evaluations of numerous interventions were being carried out using multi-sectoral data linkage, how this was also supporting DiscoverY Science and the potential for these activities to grow into normal practice for the NHS and wider public services. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Blog by Bryan Ng on DPUK website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on DPhil student Bryan Ng's project in Richard Wade-Martins' lab. Disease-in-a-dish studies open a window to a new level of detail in dementia |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.dementiasplatform.uk/blog/disease-in-a-dish-studies-open-a-window-to-a-new-level-of-deta... |
| Description | British NeuroPsychiatric Association Annual meeting 24th February - medalist Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion of nosological challanges in Dementia |
| Year(s) Of Engagement Activity | 2016,2017 |
| URL | http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf |
| Description | British Neuropsychiatric Association Annual meeting 24 February - medalist lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion of nosological challenges in dementia. |
| Year(s) Of Engagement Activity | 2016,2017 |
| URL | http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf |
| Description | Cecilia (Heyne) Lee Pint of Science Public Engagement Talk, Oxford |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Pint of Science Public Engagement Talk, Oxford, Autumn 2016 on using iPSC for modelling neurodegeneration |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk led to a lot of questions and discussion - for almost an hour after the event A number of people expressed interest in taking part in research |
| Year(s) Of Engagement Activity | 2014,2015 |
| URL | http://www.dementiasplatform.uk/event/cheltenham-science-festival/ |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands-on experiments, the MakerShack, our brand new Cyber Zone, heartbeat art there was much to explore on site in 2018! From stargazing, fun activity trails, family days and heated discussions in the Conversation Corner to a large animal dissection live on the Festival site, Cheltenham Science Festival offers science galore for all ages. Dr Tara Caffrey took part in the day to talk about her research into Tau. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.cheltenhamfestivals.com/science |
| Description | Cheltenham Science Festival (in partnership with Alzheimer's Re-search UK) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Sponsored event - How your life affects your brain. Can the way you live reduce your chance of developing Alzheimer's? By monitoring groups of people over their lifetimes, and with genetic data, brain scans and medi-cal histories researchers are building as complete a pic-ture as possible of how dementia develops. John Gallacher and Nick Fox join us to show how these stud-ies can uncover the risks involved in developing forms of dementia, and how they can be avoided. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.dementiasplatform.uk/events/?yy=2015&mm=6 |
| Description | Co-organised Synaptic Health Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A 2 day workshop for the Synaptic Health experimental medicine work package. Attendees were academics and industry scientists involved in the workpackage or who are interested in collaborating. Outcomes were decision to write a number of collaborative research proposals to obtain research funding. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Comment on the Polygenic Hazard scores for AD study by Tan et al (2019), Brain 142; 460-470 for Alzforum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I have commented on a study which was covered on Alzforum about polygenic hazard scores for AD, and shared my opinion on their availability to the public. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.alzforum.org/news/research-news/multi-gene-score-predicts-cognitive-decline-independentl... |
| Description | Competent Authorities for Medical Devices Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion to influence policy and practice relating to medical devices. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Creation of wademartinslab_oxford instgram account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Account for Wade-Martins lab for Molecular Neurodegeneration, University of Oxford to share news |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.instagram.com/wademartinslab_oxford/ |
| Description | DPUK Annual Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | DPUK's annual scientific conference 2017 is open to researchers, funders, government, charities and the public. The keynote speaker will be Monique Breteler. The focus of the day will be on demonstrating tools, presenting data on outcomes to date, and showcasing the complementarity of the Dementia Resource Institute and Dementias Platform UK. This will be the fourth DPUK conference. |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017 |
| URL | http://www.dementiasplatform.uk/event/dementias-platform-uk-annual-conference-2016/ |
| Description | DPUK Cohort Engagement Seminar |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | The purpose of the Cohort Seminar is to provide an overview of the Dementias Platform UK, build relationships with cohorts and formally invite cohorts to be part of DPUK. |
| Year(s) Of Engagement Activity | 2015,2016 |
| URL | http://www.dementiasplatform.uk/events/?yy=2016&mm=1 |
| Description | DPUK Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The DPUK newsletter is issued three times a year. It regularly includes updates from the Director, notifications of the conference and other events, news on project successes, and information on collaborative activity and any awards available. Through the newsletter, there is increased engagement from the project's target audiences with DPUK's work and events. |
| Year(s) Of Engagement Activity | 2015,2016,2017 |
| URL | http://www.dementiasplatform.uk/info-support/newsletters-and-reports/ |
| Description | DPUK Stakeholders Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Raised awareness of use of stem cells in dementia research |
| Year(s) Of Engagement Activity | 2015 |
| Description | DPUK Website feature iPSCs: a shared resource |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Information on iPSC labs on DPUK website accessible in the "For Researchers" tab then "Our Research Communities" |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.dementiasplatform.uk/our-impact/ipscs-a-shared-resource |
| Description | Data Linkage to Cohort Studies. Presentation to CLOSER research group, London - 3/11/14 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Data Linkage to Cohort Studies. Presentation to CLOSER research group, London |
| Year(s) Of Engagement Activity | 2014 |
| Description | Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff - 27/11/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Data Linkage: an essential tool for efficient observational and interventional research and service delivery. Keynote address at Public Health Science Conference, Cardiff |
| Year(s) Of Engagement Activity | 2016 |
| Description | Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton - 11/10/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Data science: solving the grand challenge of interdisciplinary working for UK biomedical, clinical and epidemiological sciences. Invited presentation at UK Roadmap for Biomedical Metabolic Phenotyping retreat, Wellcome Genome Campus, Hinxton |
| Year(s) Of Engagement Activity | 2016 |
| Description | Daybreak Lectures on issues around dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Phillippa Carling gave a brief overview of her work on drug discovery lab at ODDI, with some videos of some of their equipment. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Dementia Awareness Morning - Bryan Ng |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Bryan Ng helped out at a dementia awareness event at the John Radcliffe Hospital. This was a morning of talks about research into dementia in and around Oxford and a chance for the public to meet researchers and find out about support services available for people living with dementia. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oxdare.ox.ac.uk/public-events |
| Description | Dementia and Neurodegeneration Network Ireland (DNNI) Inaugural conference (30 November 2017) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | explore current research/future directions in the Dementia/Neurodegeneration field, effective funding models for research and the importance of interdisciplinary collaboration. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.eventbrite.ie/e/dnni-conference-2017-tickets-37728733658# |
| Description | Dementia and a Research Institute - Interview in the Sun Newspaper 5Oct15 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Publicity to promote the fact that 5p from each carrier bag bought would be donated to the Dementia Research Centre. This was the brainchild of Malcolm Walker (Iceland) with Nick Fox (DRC) |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.thesun.co.uk/sol/homepage/woman/health/health/6735025/5p-bags-could-help-combat-dementia.... |
| Description | Dementia: population and public health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given for the visit of the DRI director on 19 October 2016 at the University of Cambridge, IPH. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dementias Platform UK (DPUK) Scientific Symposium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The purpose of the Symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically looking at the main themes of Cohorts, Networks and Experimental Medicine. |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | Dementias Platform UK (DPUK) scientific symposium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The purpose of this symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically look at the main themes of Cohorts, Networks and Experimental Medicine |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018 |
| Description | Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board - 15/12/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dementias Research Platform UK. Presentation to Farr Institute International Advisory Board, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London - 24/11/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Developments in data sharing technologies at Farr centre in Swansea: UKSeRP and NRDAs. MRC Stratified Medicine consortia, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | EPAD consortium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attendance at event to collaborate with partners to share progress in dementia research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Ethical Risk Assessment in Biomedical Big Data - Protecting privacy through design |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Protecting privacy through design |
| Year(s) Of Engagement Activity | 2016 |
| Description | European Brain Council Strategic Workshop (13 and 14 September 2017) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | EBC members and people working in the Value of Treatment White Paper. To explore new areas of project development for the EBC and the continuation of their Value of Treatment White Paper. |
| Year(s) Of Engagement Activity | 2017 |
| Description | European Medical Information Framework |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 75 EMIF team members gathered in Budapest March 14-16, 2016 to not only share status updates on the ongoing work, but also discuss new joint AD/Metabolic scientific questions to be addressed using the EMIF framework. Overall, tremendous progress was shown for both research projects, with many more exciting results being underway and opportunities for further collaboration identified. In particular the overlap between AD and metabolic disorders, due to inflammation, such as in Diabetes Mellitus Type 2, has provided opportunities for shared work. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.emif.eu/news?news_news=5 |
| Description | European Medical Information Framework conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research conference to demonstrate use of new tools and methods for the dementias research community. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.emif.eu/ |
| Description | External talk at the ITMAT workshop on data science challenges and opportunities in Translational Medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk to influence research on data science challenges. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference - 24/8/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Farr Institute: Distributed multi-disciplinary team science in action. International Population Data Linkage Network Conference, Swansea |
| Year(s) Of Engagement Activity | 2016 |
| Description | Generation Scotland Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Awareness raising for DPUK and building networks. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Hong Kong University - international lectures |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | These numerous lectures provided DPUK in depth overview and dementia related discussions. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Inaugural academic conference: Tools for science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Inaugural conference for Dementias Platform UK to engage researchers in our academic and industry partner institutions and beyond. Presentations from speakers covering all areas of the Dementia Platform and cohorts encouraged to join the platform. Engagement of early career researchers through a poster presentation competition. 37 posters were exhibited, some with interactive stands, and demonstrated the progress of work delivered through the DPUK Work Programme and Infrastructure Networks. Dr Carol Routledge discussed the opportunities available through the Dementia Discover Fund and Maria Carrillo, PhD, Chief Science Officer from Chicago gave her first impression of DPUK "The Dementias Platform UK and Alzheimer's Association have a lot of opportunity to collaborate in the future in my view and John Gallacher and his team have also agreed with that, and this is one of the reasons why we have been asked to listen in and help future thinking and brainstorm ideas that might come about with DPUK's established network." |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.dementiasplatform.uk/tools-for-science-dpuks-first-annual-conference-in-brief/ |
| Description | Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London - 19/10/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Informatics and Population Health Sciences. Presentation to MRC Population Health Strategy Board, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London - 23/11/15 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Informatics, epidemiology and interventions: Network working and coordination of data resources. MRC Neurodevelopmental Disorders Research Network, London Decision made that a Neurodevelopmental Disorders Research Network would require a data platform similar to the Dementias Research Platform UK |
| Year(s) Of Engagement Activity | 2015 |
| Description | Insight 46 launch facebook offices |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Talk sparked questions and included George Freeman MP - Minister for Life Sciences A number of members of the audience asked for further information |
| Year(s) Of Engagement Activity | 2015 |
| Description | International Alzheimer's Disease Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participation in international conference. This was an opportunity to share progress and updates in dementia research infrastructure with Alzheimer's Disease Research Network, SRT Ageing, & Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong Co-organized this with the Faculty of Architecture, Faculty of Social Sciences, Sau Po Centre on Ageing & SRT Science of Learning, The University of Hong Kong, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Shenzhen University (College of Life Sciences), Hong Kong Science & Technology Parks Corporation, & The Hong Kong Society of Aging Research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Interview in Civil Service Fast Stream blog - How Stem Cells Can Boost Our Knowledge and Understanding of the Causes of Dementia |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | This is the third and final in a series of interviews carried out by a group of civil servants that have dedicated time to raising money and awareness for dementia via 'The Fund', a Fast Stream initiative. Alison Leishman, Home Office, interviewed Professor Wade-Martins about his research into dementia. Richard discussed OPDC and the DPUK. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://faststream.blog.gov.uk/2016/05/20/the-fascinating-world-of-research/ |
| Description | Janssen Symposium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discussion and collaboration with industry partners. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Joint Programme for Neurodegenerative Disease (JPND) Scientific Advisory Board (SAB) strategic workshop on precision medicine (13 March 2017) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The purpose of the workshop is to bring together clinicians, basic scientists and industry scientists to examine how the precision/stratified medicine concept can be applied to neurodegenerative disease research. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Late night event at The Science Museum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Launch of the MRC UK Dementias Platform, Royal Society, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 200 people attended the conference launch. I presented as leader of the Informatics Platform Work Package in the morning and the interactive discussion with industry in the afternoon a number of contacts were made with industry colleagues with plans for follow up meetings |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.mrc.ac.uk/research/facilities/dementias-research-platform-uk/ |
| Description | MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London - 6/7/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | MED-BIO: Links to Farr Institute and CIPHER. Presentation to MED-BIO MRC bioinformatics centre, London |
| Year(s) Of Engagement Activity | 2016 |
| Description | MS Society Public Event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | A presentation to members of the MS Society |
| Year(s) Of Engagement Activity | 2016 |
| Description | Medicine and Me: Living well with Dementia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Giving a talk on types and diagnosis of dementia at this half day meeting. The Medicine and Me series of meetings at the RSM aim to update on important conditions and gives a direct voice to patients and their carers to air their concerns on the impact of diagnosis, investigation and management. Physicians and surgeons and indeed all healthcare professionals continue to learn from and be inspired to greater efforts by our patients to improve care. The audience at this meeting will comprise of those living with dementia, their families, carers and advocates, representing about 70% of those present; and clinicians and researchers, representing not more than 30%. Clinicians will include doctors, specialist nurses and others involved in the treatment and care of those who have this condition |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.rsm.ac.uk/events/events-listing/2015-2016/groups/public-engagement-programme/mmg01-medic... |
| Description | Meetings with Insight46 donors via ARUK |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Meeting with Insight46 donors via ARUK to discuss Insight46 and dementia research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Melodem progress meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participation in a progress meeting for dementia researchers. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Agenda_Melodem_30June-and-1-july-2016_v1.... |
| Description | Mental Health Data Science Meeting (event part-funded by Farr Institute CIPHER) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Assessment of complex interventions using routine data |
| Year(s) Of Engagement Activity | 2016 |
| Description | Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods - 6/7/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Multi-sectoral data linkage for intervention and policy evaluation. Invited presentation to 7th ESRC Research Methods Festival: advancing social science research methods, Bath |
| Year(s) Of Engagement Activity | 2016 |
| Description | NHS Lothian Annual Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Clinical Research : driving efficient, innovative and effective healthcare. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Nora Bengoa-Vergniory article on Celgene Fellowship |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Interviwe with Dr Nora Bengoa-Vergniory on her experience as a Celgene Fellow for the Oxford University Medical Sciences division website |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.medsci.ox.ac.uk/research/internal/funding-directory/oxford-celgene-fellowship/oxford-cel... |
| Description | November 2016, WISH Summit (Qatar) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | - |
| Year(s) Of Engagement Activity | 2016 |
| Description | OPDC Open Day 2016 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | OPDC Open Day 2016 250 OPDC study Participants and Partners registered for event. Day of talks from Michele Hu, Fahd Baig, Claudio Ruffmann, Tom Barber and Richard Wade-Martins. Discussion of what participants would like from study. Talks filmed and podcasts added to website |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.opdc.ox.ac.uk/openday2016 |
| Description | OPDC Open Day talks online |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | A series of talks recorded at the 2018 OPDC Particpant's day are available to view on our YouTube channel and on our website. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.opdc.ox.ac.uk/videos |
| Description | OPDC Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | We held a research day to present an update on current Parkinson's research in the region and invited members of our SAB from overseas to present their work. This was attended by researchers from accross Oxford as well as members of the local Parkinon's UK group and interested study participants. We invited Hazel Stanyon, a study partiicpants who apoke about her experiences of how exercise has helped her Parkinson's symptoms and shared a poem. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.opdc.ox.ac.uk/research2018 |
| Description | OPDC YouTube channel |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Creation of OPDC YouTube channel to collate our podcasts etc. 32 subscribers, >2,860 views Feb 2016-Jan 2017. 2016 talks >1,450 views, 2016 OPDC highlights video >350 views, 2015 talks >1,000 views |
| Year(s) Of Engagement Activity | 2015,2016 |
| URL | http://www.youtube.com/channel/UCGzboizARwaAUFW5FjPmmZw |
| Description | Oxford Dementia Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The event showcased the latest developments in memory, dementia and ageing research from cells and animal models to cognitive neuroscience and the clinic. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.dpag.ox.ac.uk/research/wade-martins-group/oxford-aruk-network-centre/research-day-2015 |
| Description | Oxford Sparks'animation about the role of microglia in neurodegeneration |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Postdoc Hazel Roberts won Oxford Sparks' competition to have an animation made about the role of microglia in neurodegeneration. Title: Discovering life-changing dementia treatments. Your beautiful, complex brain is a network of microscopic cells that connect together to form your thoughts and personality, and control your body. The network is fragile and requires constant upkeep, like a garden. The brain has its own gardeners, specialised cells called microglia. In this animation we look at how researchers at the University of Oxford are developing drug treatments for Alzheimer's disease, by harnessing the power of the brain's microglia. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oxfordsparks.ox.ac.uk/content/discovering-life-changing-dementia-treatments |
| Description | Parkinson's Oxford Walk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | Members of OPDC took part in Parkinson's UK Oxford Walk. OPDC also hosted an information stand at the event. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.parkinsons.org.uk/events/walk-parkinsons-oxford |
| Description | Parkinson's UK Blog Post on HDAC paper |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Blog by Claire bale on Parkinson's UK Blog Using brain cells grown from skin to find new potential drugs Researchers in Oxford are using pioneering stem cell techniques to understand the earliest problems that occur inside brain cells in Parkinson's - and hunt down new drugs that can tackle them. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://medium.com/parkinsons-uk/using-brain-cells-grown-from-skin-to-find-new-potential-drugs-78f56... |
| Description | Pharma partnerships under CDA |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | A series of six pharma partnership meetings related to PSP and FTD novel therapeutics, under CDA/NDA Scoping the needs and opportunity, reviewing candidate product preclinical data, and developing better trial design, |
| Year(s) Of Engagement Activity | 2018 |
| Description | Plenary Speaker at Clinical Trials in Alzheimer's Disease (CTAD) conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Plenary Speaker at European Academy of Neurology on Imaging Trials and Dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Plenary speaker: Cypriot Neurological Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2015 |
| Description | Plenary speaker: The neurology of ageing, ABN Annual Meeting, Brighton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Population data and modelling: dementia as exemplar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk was given at the Cumberland Initiative Festival of Evidence on 5 October 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Poster at Advances in Neurodegenerative Disease Research and Therapy/New Frontiers in Neuroinflammation Keystone Conference, Colorado USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Nora Bengoa-Vergniory poster "Tau-proximity ligation assay detects pathology ahead of tau neurofibrillary tangles in Alzheimer's disease" As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.keystonesymposia.org/18Z3 |
| Description | Poster presentation at CTAD conference, Barcelona 24-27th October 2018: Psychometric methodologies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentaton of research work entitled: Psychometric methodologies to increase scale-reliability in dementia-focused epidemiology: Outcomes from the European Prevention of Alzheimer's Disease Study & UK Biobank. This work will be published in a peer reviewed journal at a later date. This work has gained great interest from the epidemiological community and further work in this field is planned as well as a grant application. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ctad-alzheimer.com/ |
| Description | Presentation at High Performance Computing and Big Data Conference, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation title - Improving health through Big Data - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation at International Health Data Linkage Conference, Vancouver |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation title - Using data linkage to support measurement of the Global Burden of Injuries - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation at MRC Strategic meeting between health and bioinformatics centres - 29/1/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Centre for Improvement of Population Health through E-records Research (CIPHER). Presentation at MRC Strategic meeting between health and bioinformatics centres, Windsor |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation at MRC organised conference: Strengthening the UK's capability in health informatics research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation as MRC organised conference: Strengthening the UK's capability in health informatics research. Conference was attended by 200+ delegates including, UK Minister, policymakers, research community and industry Agreement to create the Farr Institute; development of the UK Health Informatics Research Network |
| Year(s) Of Engagement Activity | 2013 |
| Description | Presentation on Health / Bioinformatics at Swansea University. Visit of Prof Julie Williams, Chief Scientific Advisor for Wales |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation on UK Secure eResearch Platform (DPUK) - 24/11/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on UK Secure eResearch Platform (DPUK) at MRC meeting 'Managing the data life-cycle for stratified medicine', London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation on future Farr UK Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on future Farr UK Institute to MRC Population Health Sciences Group, London |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation on research at Farr Institute CIPHER to Rebecca Endean - 26/1/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation on research at Farr Institute CIPHER to Rebecca Endean, Director Research Base, Business and Science |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation to Clinithink, Swansea - 10/4/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | NLP of Emergency Department data: Early experience. Presentation to Clinithink, Swansea |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation to MRC Council - Centre for the Improvement of Population Health through E-records Research (CIPHER) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation to MRC Council on the success of the Farr CIPHER centre and its impact through science and public engagement, including the development of data sharing research platforms that underpin a number of major research initiatives, including DPUK and MQ Adolescent Mental Health Platform |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation to Precision Medicine Catapult - 17/11/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation to Precision Medicine Catapult tem leaders from Cambridge University at visit to Swansea University Precision Medicine Catapult team asked to come back to discuss opportunities and projects in more detail |
| Year(s) Of Engagement Activity | 2015 |
| Description | Presentation to UK Biobank and Oxford Big Data Institute, Swansea |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation title - Use of UK Secure e-Research Platform (UKSeRP) - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation to joint meeting of UKDP, EMIF (European Medical Information Framework) and eTRIKS (European Translational Information and Knowledge Management Services), London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation title - UK Dementia Platform Informatics - |
| Year(s) Of Engagement Activity | 2014 |
| Description | Presentation to the MEPs about DPUK, EPAD and ROADMAP |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presentation to MEPs about DPUK, EPAD and ROADMAP. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation to the general public on the DRI program at the DRI launch in Cardiff |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I have presented on my DRI program "Bioinformatics and Functional genomics" to patients, their families, journalists and other invited guests from the general public at the DRI launch in Cardiff, October 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation with Mick Dennis (Swansea) and Daniel Davies (UCL) to UK Biobank/DPUK neorodegerative outcomes group - 6/1/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research Proposal: Dementia and Cognitive Impairment identification in routine health data: development and validation of algorithms within SAIL using CFAS cases. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Privacy protecting data linkage for population health. Presentation for Fondazione Lanza, Padua - 2/12/14 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Privacy protecting data linkage for population health. Presentation for Fondazione Lanza, Padua |
| Year(s) Of Engagement Activity | 2014 |
| Description | Prof Joanna Wardlaw feature in Health Matters magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A feature in Health Matters magazine, Winter 2018-2019 issue, P 24-25. Wardlaw, JM. "MRI scans of the brain". |
| Year(s) Of Engagement Activity | 2019 |
| Description | Prof Joanna Wardlaw lecture "Brain Health: a small matter of the blood vessels" in Edinburgh, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Edinburgh Neuroscience Public Christmas Lecture 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Q&A session at Rare Dementia Support Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Question and Answer session from patients and carers with a diagnosis of frontotemporal dementia |
| Year(s) Of Engagement Activity | 2017 |
| Description | Radio Interviews on Parkinson's |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Radio interview to raise awareness and Parkinson's fund raising sponsored event Raised awareness and money |
| Year(s) Of Engagement Activity | 2015 |
| Description | Rare Dementia Support Group Launch 2016 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Rare Dementia Support Fund created with the ambition to increase fundraising and extend the support service further, throughout the UK and beyond. Extremely well attended |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.nationalbrainappeal.org/rare-dementia-support-launch-event/ |
| Description | Royal College of Physicians 'Women in medicine: a celebration' project |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Royal College of Physicians (RCP)'s 'Women in medicine: a celebration' project is a free exhibition of specially commissioned photographic portraits to honour contemporary and historical women in medicine. The project showcased a number of today's leading female clinicians and the women from the history of medicine who have inspired them. Prof Joanna Wardlaw is featured in the project alongside someone who inspired her, Marie Sklodowska Curie: https://www.rcplondon.ac.uk/projects/outputs/women-medicine-joanna-wardlaw-and-marie-curie |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.rcplondon.ac.uk/events/women-medicine-celebration |
| Description | School of Medicine 'Science in Health' Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Professor John Gallagher spoke at a Cardiff University public medical lecture and the aim of these lectures is to open up areas of concern in health care, and second, to inform the public about current medical research. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.dementiasplatform.uk/event/school-of-medicine-science-in-health-public-lecture/ |
| Description | Section on DPUK website to formally request stem cell lines |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | A section on iPSC resources for researchers on the DPUK website provides the opportunity for researchers to formally request over 100 stem cell lines derived from healthy and diseased individuals. This resource focused section is complemented by two detailed reports in the "Our impact" section of the web-site. |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso... |
| Description | Secure Anonymised Information Linkage (SAIL) system. Educational presentation to the Confidentiality Advisory Group, Health Research Authority - 7/9/16 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Secure Anonymised Information Linkage (SAIL) system. Educational presentation to the Confidentiality Advisory Group, Health Research Authority, London |
| Year(s) Of Engagement Activity | 2016 |
| Description | Social Media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The social media presence of Dementias Platform UK is intended to demonstrate the core personality of the project, sharing: - Expert voice - A network of research excellence - Human connection. DPUK's social media presence is focused on Twitter, though in the future it may also reach LinkedIn. Social media is used to share updates on the project's work: its research, daily activity, funding awards open, news, and any open recruitments, It also demonstrates its networked and human approach by sharing content from charities, linked researchers and any current human interest news stories. Finally, in the coming months it will strengthen its ability to share its expert voice by facilitating twitter takeovers from key researchers, particularly Early Career Researchers. DPUK has 1,636 followers - a 173% increase on 2016. |
| Year(s) Of Engagement Activity | 2006,2015,2016,2017 |
| URL | https://twitter.com/dementiasuk |
| Description | Speaker at Primary Progressive Aphasia: BNPA Annual Meeting, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Speaker at launch of UK Dementia Platform |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Oxford plays a significant role in the partnership and Oxford Neuroscience researchers lead a number of projects. This was reflected in the scientific programme of launch day. Simon Lovestone (Psychiatry) gave a talk on the NIHR-MRC Dementia Deep and Frequent Phenotyping Feasibility Study while Richard Wade-Martins (DPAG) spoke on the UK Stem Cell Network. Coverage in the media |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.dementiasplatform.uk/ |
| Description | Speaking Cambridge Dementia Course: MRI in dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Speaking at EAN, Copenhagen, Focal dementias, Convener, lecturer |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Speaking re fluid biomarkers in AD. Educational Workshop. AAIC, Toronto |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Speaking re young onset dementia: Royal college of Physicians, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | N/A |
| Year(s) Of Engagement Activity | 2016 |
| Description | Synaptic Health Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | A one-day workshop, and shorter follow up meetings, to engage academic and industry partners in Synaptic Health Research |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.dementiasplatform.uk/for-researchers/expert-communities-1/synaptic-health-community |
| Description | Talk at East Midlands Research Support Network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Natalie Connor-Robson - invited talk outreach, East Midlands Research Support Network, Sept 2018 Understanding Parkinson's disease - what can we learn from skin cells and mice? The East Midlands Parkinson's Research Forum is a free annual conference organised by the local Parkinson's community and supported by Parkinson's UK. The event will feature talks from top Parkinson's researchers and healthcare practitioners, Parkinson's UK staff, volunteer speakers, as well as interactive exercise sessions and a performance from The Parkinson's Choir. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.parkinsons.org.uk/events/east-midlands-parkinsons-research-forum |
| Description | Talk at Parkinson's UK Branch Richard Wade-Martins |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Prof Richard Wade-Martins on the latest projects at the Oxford Centre for Parkinson's Disease Research |
| Year(s) Of Engagement Activity | 2016 |
| Description | The Impact of Incidence Prior to Death on the Incidence of Dementia in individuals Aged 65 Years and Older |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speak at Alzheimer's Association International Conference AAIC 2017 London. |
| Year(s) Of Engagement Activity | 2017 |
| Description | The Many Faces of Dementia - massive open online course (MOOC) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interviewed for an online course about the rarer forms of dementia, my interview related to the clinical features of frontotemporal dementia. I also performed the voice over and welcome to the course that appeared in the course trailer video. The course, due to start March 14th 2016 is a 'massive open online course' available at www.futurelearn.com/courses/faces-of-dementia. Over 12,000 people have registered for the course (as of 8th March 2016). |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.futurelearn.com/courses/faces-of-dementia |
| Description | The Times |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I have given an interview to "The Times" newspaper published 22 March, 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Transforming UK Biomedical and Health Informatics. Lecture to MSc in Health Data Analytics students, Swansea - 26/10/15 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Transforming UK Biomedical and Health Informatics. Lecture to MSc in Health Data Analytics students, Swansea |
| Year(s) Of Engagement Activity | 2015 |
| Description | Twitter account for OPDC |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Active twitter feed for OPDC engages with other research groups and industry. Promotes our research, events, news and drives for study participants as well as highlighting relevant news items and publications. Jan 2019: 829 followers, average Impressions 10.6k per month |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019 |
| URL | http://twitter.com/OxfordPDCentre |
| Description | UK Medical Research Council open meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion forum with partners in the dementia research field. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Vascular risk factors in AD and other dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Personal invited to give talk at CoSTREAM Meeting of University of Cambridge. |
| Year(s) Of Engagement Activity | 2017 |
| Description | WHO Bulletin Interview with Carol |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with Carol Brayne: a life-course approach to prevent dementia https://apps.who.int/iris/handle/10665/272247 WHO Bulletin Interview with Carol |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://apps.who.int/iris/handle/10665/272247 |
| Description | Westminster forum |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Advice for policymakers on dementia research. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.westminsterforumprojects.co.uk/conference-diary |
| Description | Work with artist to produce cartoons of research |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Abstracts of posters were presented by DPAG Graduate Students at the start of their Second Year of DPhil Research Study. A cartoonist was on hand again to record the event and produced cartoons to illustrate the projects which were shared via social media. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/WadeMartinsLab/status/1074587251496095745 |
| Description | World Innovation Summit for Health (WISH) forum (February 2015) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Participated as a panel member looking at issues of dementia funding and research, and how to better inform the public. A report was subsequently published based on the Summit meeting. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.nhsq.info/app/media/4053 |
| Description | Young Onset and Rare Dementias 2014 event at House of Lords |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Awareness-raising event regarding young onset and rare dementias The event was attending by member of parliament and the House of Lords as well as charities, patient families and other organisations |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://www.youngdementiauk.org/news/young-onset-awareness-event-house-lords |
| Description | led a session on macrophages and microglia in a Stem Cell Outreach workshop for GCSE school students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Sally Cowley led a session on macrophages and microglia in a Stem Cell Outreach workshop for GCSE school students, Medical Sciences Teaching Centre, Oxford University |
| Year(s) Of Engagement Activity | 2018 |