UK Dementias Platform

Lead Research Organisation: University of Oxford
Department Name: Psychiatry

Abstract

The UK Dementias Platform (UKDP) is a radically new approach to dementias research, bringing together data from around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of slowing it down. The platform has been funded to the level of £4.5M and invited to apply for a further £7.5M.

To achieve our goals of discovering the causes of dementia and finding out ways to slow it down, we will analyse data collected over many decades from throughout the UK to identify targets for drugs studies.

We will also enrich strategically selected cohorts to provide resources for dementias research in general. This will involve finding out how the early dementia processes begin, how our genes affect our risk of dementia and where our body goes wrong in maintaining and repairing itself.

There are many practical challenges involved in doing this work including knowing how to assess dementia in large studies where having everyone examined by a doctor would be prohibitively expensive. Another challenge is how to measure cognitive decline in the population as when people begin to decline they are frequently less motivated to do cognitive tests.

There are also important ethical issues surrounding this work and we have specific projects looking at ethical legal and social issues surrounding taking part in detailed measurement studies as well as in considering brain donation.

To help make an impact as soon as possible, we will work closely with industry partners who are best placed to turn basic scientific knowledge into effective therapies.

Even if we cannot cure dementia in the short term, it would count as a success if we found ways of slowing it down so that nobody need lose their dignity as they grew older.

Technical Summary

The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and cost-effective translation pipeline from basic discovery through to early phase trials (Fig 1). By combining the analytic and statistical power of >20 clinical and population cohorts representing 2M participants and creating a large readiness cohort, UKDP will create an optimal environment for basic discovery activities relevant to the clinical progression and human impact of dementia. Although UKDP is intended as a strategic and sustainable resource generating increasing scientific benefit over time, it will also deliver short and medium term benefits through the analysis of existing data, the enrichment of strategically selected cohorts, developing new ways of working with industry, and generating interest and further funding for dementias research generally.

A single portal informatics hub (funded in stage 1) will be used for integrating data from participating cohorts and triangulating evidence between cohorts. The stage 2 proposal focuses on providing strategic resources for EM by enriching strategically selected cohorts, addressing key methodological issues and pump-priming a programme of EM studies.

Further development of the platform is anticipated as the opportunities it provides are more widely understood. For example, predicated on the ability of the platform's ability to provide accurately risk stratification, MRC and NIHR have recently funded a deep and frequent Phenotyping (DFP) feasibility study with a view to providing a further £5M for the full study. The DFP project may be considered a stage 3 development of UKDP and is an example of how UKDP can be used to leverage further resource for dementias research.

Planned Impact

The platform will use several vehicles to deliver impact.

These were described in stage 1.

In summary:

For the academic community, in addition to the proposals mad in stage 1, we will develop a network of partnerships and operate a system of working groups to actively consult the UK academic community and world experts on the direction, technologies and collaborations of the platform. Our aim is to 1) base the science of the platform on the best information available, 2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.

For industry, partnership discussions are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.

We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.

Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.

In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.

Organisations

Publications

10 25 50
 
Title 3 video interviews with research participant, senior industry scientist and senior academic researcher 
Description Three video interviews to bring the importance of dementia research and the DPUK project to life for our general public audience through our social media channels (YouTube and Twitter). 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Increased awareness of DPUK and the need for investment new ways of working in dementia research. 
URL https://www.youtube.com/watch?v=FYlkBpb_D_A
 
Title Animation - 'Introducing Dementias Platform UK' 
Description This animation has been used on the homepage and About pages of the DPUK website to give the general public an easily accessible overview of Dementias Platform UK aims and work. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Our audience research has shown that the general public find this animation useful in understanding the complex DPUK project. 
URL https://www.dementiasplatform.uk/about
 
Title DPUK newsletter (produced 3 times a year) 
Description The DPUK newsletter is sent three times a year to researchers, related organisations in the dementia research sector, industry companies working in dementia research and development and major funders in the dementia research sector. It features updates on the developments and opportunities in DPUK. 
Type Of Art Artefact (including digital) 
Year Produced 2017 
Impact Increased awareness of DPUK resources amongst key audience groups: scientists; funders and industry. 
 
Title Data Portal communications pack 
Description This pack was produced an distributed to DPUK's 16 partner organisations (10 universities and 6 pharmaceutical companies) to support the promotion of the Data Portal campaign. 
Type Of Art Artefact (including digital) 
Year Produced 2018 
Impact 150% increase in traffic driven to DPUK website; increased awareness amongst the dementia research community of DPUK's tools, resources, training and funding opportunities for researchers. 
 
Title Data Portal press release 
Description Press release to all major science publications and science desks of print media at the launch of the DPUK Data Portal. 
Type Of Art Artefact (including digital) 
Year Produced 2017 
Impact None we are aware of. 
 
Title Great Minds animated graphic 
Description An animated graphic explaining the value of cohort participants to dementia clinical studies and trials. 
Type Of Art Film/Video/Animation 
Year Produced 2019 
Impact Helped support the recruitment of 45 people to the Great Minds clinical studies register pilot, showing their interest in taking part in future dementia research. 
URL https://www.youtube.com/watch?v=TTLyYF021uA
 
Title Information sheet 
Description This information sheet was sent out to our 16 partners (10 partner universities and 6 partner pharmaceutical companies) for inclusion, alongside a news feature, in internal newsletters. 
Type Of Art Artefact (including digital) 
Year Produced 2018 
Impact Increased engagement from research scientists based at universities and in industry with DPUK's resources on the DPUK website and DPUK Data Portal website. Attendance at DPUK training webinars and expressions of interest/applications for DPUK's 'Discovery Award' funding opportunities for researchers. 
 
Title Leaflet 
Description Leaflet produced for distribution at the Alzheimer's Research UK conference. 
Type Of Art Artefact (including digital) 
Year Produced 2017 
Impact The leaflet helped to raise awareness amongst the community of dementia researchers of DPUK's free tools and data resources for researchers. 
 
Title Leaflet - 2017 
Description Leaflet produced for distribution at the Alzheimer's Association International Conference, attended by over 6000 researchers. 
Type Of Art Artefact (including digital) 
Year Produced 2017 
Impact Increased awareness amongst the dementia research community worldwide about DPUK's tools and data resources for researchers. 
 
Title Leaflet - 2018 
Description Leaflet included in the Alzheimer's Research UK 2018 conference delegate pack (going to 650 people). 
Type Of Art Artefact (including digital) 
Year Produced 2018 
Impact At the time of writing the conference itself has not yet taken place. 
 
Title MEG & ME 
Description With ISSF funding, out team held a series of public open evenings to discuss research of interest to the public, to define a sho set of questions and design the experiments to answer them, and then carry it out using MEG. The project was filmed, and presented at a final public discussion meeting at the Cambridge Science Festival 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact The project clearly caught he public's imagination, and over 100 members of the public took part across the weeks. https://vimeo.com/116423919 presents a final summary video 
URL https://vimeo.com/116423919
 
Title Magazine article 
Description John Gallacher was interviewed for this feature in Optima magazine (a lifestyle magazine) about the importance of participation in health research. 
Type Of Art Artefact (including digital) 
Year Produced 2017 
Impact Feature in Optima magazine. 
URL http://www.optimamagazine.co.uk/read/style/health/1628-banking-time
 
Title Misplaced in Space (September 2017) 
Description A collaboration with University of East Anglia, to portray the impact of Dementia 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2017 
Impact A film of the exhibition is available; 
URL https://vimeo.com/229381641
 
Title Video of DPUK conference 
Description Video of highlights from the DPUK annual conference 2017. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Use in the promotion of the 2018 annual conference amongst our key audiences. 
URL https://www.youtube.com/watch?v=TAsOtdaHkO0
 
Description ABN clinical research and academic committee, London representative
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Advisor WHO (World Health Organisation)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact N/A
 
Description Alzheimer Association Educational Workshop: The basics of fluid biomarkers in AD - speaker
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Attend technical meeting on the Implementation of the Global Action Plan on Public Health Response to Dementia
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Attended Association of British Neurologist's annual conference and delivered citation for ABN medallist
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Canadian Consortium on Neurodegeneration in Aging (CCNA)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Clinical Expert for a NICE Scientific Advice consultation on Alzheimer's Disease
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Contributor to a review of current dementia recruitment registers and its role for the public and research landscape
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Dementia Programme Board - oversee the implementation of the PM's Challenge on Dementia to 2020
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Deputy Chair, ABN Cognitive Disorders Advisory Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact N/A
 
Description German Centre for Neurodegenerative Diseases (DZNE) scientific review
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description International Advisory Committee for Healthy Brains for Healthy Lives (HBBL), McGill
Geographic Reach North America 
Policy Influence Type Participation in a advisory committee
Impact The $100 million HBBL program seeks to improve the mental helath across Canada across all age groups.
 
Description JPND SAB Meeting - re-launching its Strategic Research and Innovation Agenda (SRIA)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description MRC Dementias Platform UK 'Open Science Champion' and Steering Group member
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL http://www.mrc.ac.uk/research/facilities-and-resources-for-researchers/dementias-platform-uk/governa...
 
Description Member of the Committee on the Medical Effects of Air Pollutants (COMEAP) advisory committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Member, Biobank access committee, Brains for Dementia Research
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description Press conference
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Speaking at ARUK Policy conference: Looking forward: Towards dementia treatment - planning for the requirements to deliver new treatments for AD in the UK
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description UCL ageing event - cultivating research connections across the university: organising committee and plenary speaker
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description UK representative - European Academy of Neurology Dementia Panel
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description UK/Italy Imaging working group research partnership
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description Vice Chair and Chair Elect, Advisory Council US Alzheimer's Association ISTAART
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description WHO's Global Dementia Observatory discuss the implementation of the global action plan on public health response to dementia 2017-2025
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description Work group to establish a Danish brain research centre - Lundbeckfonden, The Brain Prize
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description World Dementia Council
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Description 1946 ARUK
Amount £1,824,093 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2014 
End 06/2017
 
Description A longitudinal amyloid-PET/MRI study of the 1946 birth cohort. ARUK-PG2017-1946.
Amount £1,216,062 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2017 
End 06/2019
 
Description A standardized, multilingual, mini linguistic state examination (MLSE) for classifying and monitoring primary progressive aphasia.
Amount £358,924 (GBP)
Funding ID RG82683 
Organisation St George's University 
Sector Academic/University
Country Grenada
Start 01/2017 
End 12/2019
 
Description ARUK ODDI collaboration: Phenotypic drug discovery in Parkinson's
Amount £200,000 (GBP)
Organisation University of Oxford 
Department Alzheimer's Research UK Oxford Drug Discovery Institute
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2020
 
Description ARUK Oxford Pilot Investigating the effect of tau on axonal transport and tau release in MAPT-iPSC cortical neuron models
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK Oxford Pilot Optogenetic light source and controller for 96/384-well plates to allow uniform illumination of wells inside a cell-culture incubator.
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK Pilot Analysis of tau secretion in iPS differentiated neuronal cultures
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK network pilot grant
Amount £5,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 03/2019
 
Description Autophagic flux 
Amount £317,137 (GBP)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2017 
End 08/2019
 
Description BRC award to UCL/H (Dementia Theme)
Amount £5,000,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 04/2022
 
Description Biomedical Research Centre Dementia Theme
Amount £118,000,000 (GBP)
Funding ID RG85367 
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description Brain Network Analysis in Neurodegenerative Tauopathies
Amount £22,391 (GBP)
Funding ID RG89925 
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description Brain Research Trust
Amount £219,355 (GBP)
Organisation Brain Research Trust (BRT) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description Brain Research Trust
Amount £219,355 (GBP)
Organisation Brain Research Trust (BRT) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description British Heart Foundation - Cardiovascular mechanisms linked to cerebral amyloid b deposition and cognitive decline: a sub study of INSIGHT 46
Amount £273,844 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 04/2022
 
Description Cerebrovascular health in older adults at a genetic risk for dementia
Amount £3,970 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 08/2018
 
Description Clinical research infrastructure
Amount £1,500,000 (GBP)
Organisation University of Cambridge 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 03/2016
 
Description Clinical research infrastructure
Amount £6,995,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 09/2020
 
Description DRI Costs
Amount £1,123,799 (GBP)
Organisation UK Dementia Research Institute 
Sector Academic/University
Country United Kingdom
Start 09/2017 
End 08/2022
 
Description Deconvoluting the dementia phenotype using functional genomics and computational approaches
Amount £537,913 (GBP)
Organisation Government of Wales 
Department Welsh European Funding Office
Sector Public
Country United Kingdom
Start 01/2018 
End 10/2022
 
Description Deep and Frequent Phenotyping; combinatorial biomarkers for dementia experimental medicine
Amount £6,301,078 (GBP)
Funding ID MR/N029941/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description Drake Foundation: Effects of head injury the NSHD 1946 birth cohort.
Amount £60,852 (GBP)
Organisation The Drake Foundation 
Sector Charity/Non Profit
Country Unknown
Start 04/2017 
End 04/2019
 
Description Drake Foundation: Head Injury, cognition and imaging correlates of dementia in the Insight 46 cohort
Amount £60,852 (GBP)
Organisation The Drake Foundation 
Sector Charity/Non Profit
Country Unknown
Start 04/2016 
End 04/2019
 
Description EU IMI-2. Amyloid imaging to prevent Alzheimer's disease (AMYPAD)
Amount £934,500 (GBP)
Organisation European Social Survey: European Research Infrastructure Consortium (ESS ERIC) 
Sector Charity/Non Profit
Country European Union (EU)
Start 10/2016 
End 09/2021
 
Description Early-onset depression: Characterising development and identifying risks
Amount £763,680 (GBP)
Funding ID MR/R004609/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 11/2020
 
Description Enhancing autophagic flux in Parkinson's disease
Amount $663,000 (USD)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2017 
End 09/2019
 
Description Farr NLP open source software development
Amount £48,470 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 10/2018
 
Description GENetic Frontotemporal dementia Imaging - Second phase (GENFI-2)
Amount £2,613,582 (GBP)
Funding ID MR/M023664/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2015 
End 04/2020
 
Description High content imaging of iPSC-derived neurons to dissect mechanisms of Parkinson's
Amount £80,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2021
 
Description Improving prevention trials in AD through imaging
Amount £249,965 (GBP)
Funding ID 261 (AS-PG-15-025) 
Organisation Alzheimer’s Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 02/2017
 
Description JPND
Amount £350,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2016 
End 05/2019
 
Description JPND EUFIND
Amount £30,000 (GBP)
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND) 
Sector Public
Country European Union (EU)
Start 10/2016 
End 10/2017
 
Description MIND-MAPS
Amount £977,920 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2017 
End 03/2020
 
Description MJ Fox Therapeutic Pipeline Program: Enhancing autophagy flux in Parkinson's disease
Amount $330,000 (USD)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start  
 
Description MRC COEN
Amount £150,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 06/2018
 
Description MRC Momentum Award (Microglial interactions in Alzheimer's Disease)
Amount £4,300,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
 
Description MRC Momentum Award (Microglial interactions in Alzheimer's Disease-informatics)
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Partnership Award (Dementias Platform UK Stem Cell Partnership)
Amount £1,200,000 (GBP)
Funding ID MR/N013255/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2016 
End 06/2020
 
Description MRC Partnership grant for UK7T
Amount £220,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2016 
End 03/2019
 
Description MRC UK Dementia Research Institute Award - Dementia Bench to Bedside
Amount £6,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2017 
End 10/2022
 
Description MRC-KHIDI UK-KOREA PARTNERING AWARDS
Amount £100,000 (GBP)
Funding ID MC_PC_17105 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 04/2018
 
Description MRC-NIH UK-US Dementia Research Collaboration programme
Amount £11,000 (GBP)
Funding ID MC_PC_17204 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2018 
End 03/2019
 
Description Mental Health Pathfinder Award
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description NTAD: new-therapeutics-in-alzheimers-disease
Amount £1,200,000 (GBP)
Organisation MRC Dementias Platform UK 
Sector Public
Country United Kingdom
Start 06/2018 
End 09/2020
 
Description New Therapeutics in Alzheimer s Disease (NTAD) - ARUK
Amount £100,000 (GBP)
Funding ID RG89702 
Organisation Versus Arthritis 
Start 10/2017 
End 08/2020
 
Description Oxford Biomedical Research Centre (BRC)
Amount £45,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start  
 
Description Oxford Medical Sciences Divisions Returning Carer Fund (Tara Caffrey)
Amount £5,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 02/2017 
End 05/2017
 
Description Predicting dementia outcomes using simple, non-invasive assessments: a prospective population-based study
Amount £207,016 (GBP)
Funding ID MR/P001823/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 08/2016 
End 07/2019
 
Description Restoring noradrenergic function to improve apathy in Parkinson s disease to Claire O Callaghan
Amount £49,677 (GBP)
Funding ID RG90797 
Organisation Parkinson's UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 07/2018
 
Description Rosetrees: Detecting and tracking brain changes in early Alzheimer's Disease
Amount £248,130 (GBP)
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2017 
End 08/2020
 
Description Sanofi/Genzyme: Modulating GBA activity as a Parkinson's disease therapy
Amount £200,000 (GBP)
Organisation Sanofi 
Department Genzyme Therapeutics Ltd
Sector Private
Country United Kingdom
Start 11/2016 
End 10/2017
 
Description Stratification of bipolar disorder: Harnessing clinical heterogeneity and genetics shared with other disorders
Amount £310,234 (GBP)
Funding ID Judith Allardyce 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 12/2021
 
Description Targeting lysosomes to enhance autophagy in Parkinson's
Amount £201,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2019
 
Description The Airwave Health Monitoring Study (AHMS). An Occupational Cohort Study of the British Police Forces
Amount £1,941,097 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2018 
End 04/2023
 
Description The physiology of dementia: magnetoencephalographic investigation of brain networks in frontotemporal lobar degeneration and Alzheimer's disease in preparation for experimental medicine studies.
Amount £49,592 (GBP)
Funding ID RG84879 
Organisation Versus Arthritis 
Start 10/2016 
End 09/2017
 
Description UKRI Innovation / Rutherford Fund Fellowships at HDR UK
Amount £560,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 02/2021
 
Description Uniting iPSCS and CRISPR/Cas9 screens- a platform to model and interrogate genetic disease in Oxford
Amount £80,000 (GBP)
Organisation University of Edinburgh 
Department Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 12/2017 
End 06/2019
 
Description Wales/NI substantive site. HDR UK
Amount £3,003,650 (GBP)
Organisation Health Data Research UK 
Start 05/2018 
End 04/2023
 
Description Wellcome Trust Clinical Research Training Fellowship
Amount £174,791 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description Wellcome Trust Clinical Training Fellowship
Amount £174,791 (GBP)
Organisation Wellcome Trust 
Department Wellcome Trust Bloomsbury Centre
Sector Academic/University
Country United Kingdom
Start 04/2016 
End 03/2019
 
Description Weston Brain Institute - Developing blood based biomarkers to detect pre-clinical Alzheimer's disease and predict progression
Amount £329,663 (GBP)
Organisation Weston Brain Institute 
Start 12/2020 
End 12/2020
 
Description What makes strategic stroke strategic? Multimodal imaging and network methods to predict dementia after strategic stroke
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 08/2017
 
Description Wolfson Foundation: Ageing Cohort
Amount £887,193 (GBP)
Organisation The Wolfson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2013 
End 03/2019
 
Title BIOFIND output 
Description The JPND BioIND project was led from MRC-CBU, as an international collaboration to standardize and harmonize methods for dementia research. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2019 
Provided To Others? Yes  
Impact Data sharing across sites, the open science methods and a publication pending are outputs related to the validation and recommendations made. The research tool is part of the growing recognition of MEG's potential to transform dementia research, with novel mechanistic insights and trials outcomes, provided that industry-readiness benchmarks can be met. 
URL http://www.neurodegenerationresearch.eu/initiatives/annual-calls-for-proposals/closed-calls/brain-im...
 
Title CRISPR gene editing 
Description We have been able to establish CRISPR/Cas9 gene editing in our lab as a result of this project 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact We have been able to perform gene editing in iPSC lines. 
 
Title DPUK Data Portal 
Description The DPUK Data Portal has been relaunched to include a seamless transition from the DPUK main welcome site into the research infrastructure. The Portal, hosted by Swansea University, now includes openly available metadata on the DPUK cohorts, as well as information on the various parts of the infrastructure, which include: Portal analysis environment powered by virtual desktop infrastructure, imaging platform powered by XNAT, genetic platform created by Digital Health Labs, data linkage possibilities using world-leading matching technology, and a new and easy-to-use application form for researchers to apply for access to data, based on categorised dementia-specific data ontologies. The Portal is now supporting data access applications with dedicated resource to manage this process, and data management based on consultation with other data consortia and the cohorts themselves is underway using novel data management infrastructure (research data appliance based at Swansea University), enabling governance to remain entirely with the data provider and data access permissions to be managed by a central facility. 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact The relaunch of the Portal has seen a surge in scientific collaboration in DPUK - for the period November 2017-January 2018, there are 12 live studies on the Portal, all using multiple cohorts and all cross-institution, including internationally-led studies from Maastricht University and the University of Hong Kong. These studies have primarily phenotypic data as their main modality, however we are also seeing the combination of phenotypic, genotypic and imaging data in studies, thus showing the power of a central system for accessing and analysing data from previously disparate sources. Genetics and imaging work packages are also contributing to the studies being supported by DPUK, and the Portal is making data available to specialists in these areas in order for them to derive services for the epidemiological community to make use of data that was previously unobtainable, either due to access difficulties or specialist intervention being necessary. 
URL https://portal.dementiasplatform.uk/
 
Title DPUK Imaging Network- Harmonising of Imaging protocols 
Description One important aspect of the work of the DPUK Imaging Network is the harmonising and optimising of protocols for image data acquisition, reconstruction, and analysis. This is currently in progress. There is a dedicated website for the MR/PET Partnership, a sub-group within the Imaging Network. The harmonised protocols will appear here once available: https://www.dpuk-mripet.info/ 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact Complete harmonisation has yet to be achieved but this should happen in the first half of 2019. 
 
Title DPUK Stem Cell Network iPSC directory resource for researchers 
Description Members of the DPUK Stem Cell Network have produced a directory listing over 100 iPSC lines that could be made available to researchers in collaboration with the labs who generated the lines. The directory can be found on the DPUK website. It is available via the DPUK website and contact being made with the lead researcher who generated the lines. 
Type Of Material Cell line 
Year Produced 2018 
Provided To Others? Yes  
Impact The Stem Cell Network has published a range of papers using the resource. For an illustrative example please see a recent 2019 paper from the laboratory of Professor Richard Wade- Martins, the lead of the Stem Cell Network. https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddz038/5315478 
URL https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso...
 
Title Dementia Diagnosis Algorithm for use in primary care, hospital admissions or mortality datasets 
Description The researchers from DPUK WP9 used data from ~17,000 UK Biobank participants to identify participants with one or more dementia codes in primary care, hospital admissions or mortality datasets, and compared the coded data to the full-text medical record. Having validated the accuracy of these datasets, they then developed algorithms that can be applied to identify participants with dementia in UK Biobank and other DPUK cohorts. The authors will continue this promising work by investigating sources of potential bias in the data and the generalisability of these findings to older ages and other geographical areas. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2019 
Provided To Others? Yes  
Impact This is an initial validation study which has proved that the methodology works. Following recent publication of the results (March 2019) the work will be expanded and the findings built-on. 
 
Title Development of an enhanced Cognitive Assessment for UK Biobank 
Description A DPUK funded group (WP10) led by Ian Deary in Edinburgh are working closely with UK Biobank to develop an enhanced cognitive assessment, including tests of cognitive function known to be sensitive to ageing. This includes more detailed tests of declarative memory, reasoning and executive function. There are some limitations of the scope for the tests; a brief period of time is allowed for testing to fit with any planned clinical visits for UK Biobank participants and it has to be self-administered on a computer touch screen. The group has produced a report for UK Biobank on the enhanced UK Biobank cognitive assessment and provided their preliminary assessment of the test characteristics. Subject to UK Biobank approval, it is hoped to provide details of the tests on the DPUK website. Preliminary report to UK Biobank is dated 21.09.2017 and is in the process of being updated. 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2017 
Provided To Others? Yes  
Impact There has been a revision of the tests administered in UK Biobank and an improvement in their quality. This means that they are now more informative for investigating the variety and subtlety of cognitive changes seem in both healthy and pathological ageing. 
 
Title Dopamine neuron microfluidics 
Description Development of stem cell-derived neuronal culture techniques using microfluidic devices to channel axonal growth. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact Not yet: it is ongoing development 
 
Title Generation of MAPT CRISPR gene edited iPSC lines 
Description We have generated 8 QCed MAPT-­/-­ knockout lines on 2 control backgrounds. 
Type Of Material Cell line 
Year Produced 2018 
Provided To Others? No  
Impact We will use the MAPT-/- iPSC-derived neurons to study the role of MAPT in Parkinson's 
 
Title Generation of SNCA CRISPR gene edited iPSC lines 
Description We have generated 3 QCed SNCA-­/-­ knockout lines on control background and isogenic correction of SNCA Triplication patient line (and also knockout) - clones identified by droplet digital PCR, undergoing confirmatory sequencing. 
Type Of Material Cell line 
Year Produced 2018 
Provided To Others? No  
Impact Generation of SNCA CRISPR gene edited lines will further our work on the role of macrophages and microglia on the uptake/processing/secretion of alpha-­synuclein and its role in stimulating the immune response and enable us to interrogate the mechanism for the phagocytosis defect phenotype observed in the SNCA-­Triplication macrophages/microglia. 
 
Title High content, high throughput analysis 
Description The ability to perform detailed high-throughput analysis of neurons in culture 
Type Of Material Technology assay or reagent 
Year Produced 2016 
Provided To Others? Yes  
Impact Shared use of best practice in high-throughput analysis using Opera Phenix imager and high-throughout plate readers 
 
Title In vitro electrophysiology 
Description Patch-clamp techniques to measure neuronal activity of stem cell-derived neurons 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Analaysis of stem cell-derived neurons: dopamine neurons, cortical neurons, motor neurons and medium spiny neurons 
 
Title Live cell imaging techniques in iPS-derived DA neurons in vitro 
Description We have optimised a live cell imaging protocol for the visualisation and measurement of mitochondrial membrane potential in differentiated neurons. 
Type Of Material Cell line 
Provided To Others? No  
Impact The membrane potential-sensing dye TMRM can be used to quantify membrane potential, with increased fluorescence indicating increased membrane potential. 
 
Title Microglia differentiation 
Description The ability to generate microglia from human stem cells from dementia patients 
Type Of Material Cell line 
Provided To Others? No  
Impact We will be able to compare the function of microglia generated from patients and from controls 
 
Title PLA in stem cell neurons 
Description To enable the detection of a-syn oligomers in stem cell-derived dopamine neurons 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The detection of a-syn oligomers in stem cell-derived dopamine neurons 
 
Title RNA-Seq 
Description Development of methods for analysis of RNA-Seq 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Understanding of gene expression profiles in selected cell population 
 
Title Target discovery assays 
Description Develop target discovery assays using high throughput screens 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact New research facilty built for our work 
 
Title iPSC phenotypic screens 
Description We have developed an organelle calcium flux assay for high-throughput screening and applied the assay to screen 4000 small molecules in Parkinson's patient iPSC-dervied dopamine neurons. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact We will use the assay to identify new therapeutic targets or novel and or repurposable small molecule therapeutics. 
 
Title Alzhemer's Disease Polygenic Risk Profiling 
Description This model used data from the powerful dataset comprising 17 008 cases and 37 154 controls obtained from the International Genomics of Alzheimer's Project (IGAP). Alzheimer's disease (AD) Polygenic risk scores were generated for 3177 cases and 7277 controls (GERAD data) and tested whether the alleles identified to associate with disease in IGAP sample are significantly enriched in the cases relative to the controls in the GERAD sample. The disease prediction accuracy was investigated in a sample of 3049 cases and 1554 controls (for whom APOE genotype data was available) by means of sensitivity, specificity, area under the receiver operating characteristic curve (AUC) and positive and negative predictive values. The best prediction accuracy AUC = 78.2% (95% confidence interval 77-80%) was achieved by a logistic regression model with APOE, the polygenic score, sex and age as predictors. 
Type Of Material Computer model/algorithm 
Year Produced 2016 
Provided To Others? Yes  
Impact This approach is used to create SNP arrays for AD prediction (for research only so far). 
 
Title Cam-CAN 
Description Cam-CAN project extended to include subarm of "Cam-CAn Frail" and early dementia participants. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact Extensive applications for data from CC700; Cam-CAN-Frail still in data acquisition phase. 
 
Title DPUK 7T data sharing 
Description Agreement on data sharing for 7T images using DPUK XNAT platform 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact pending 
 
Title SAIL Dementia eCohort (SAILDeC) 
Description DPUK has funded the creation of the SAIL (Secure Anonymised Information Linkage) Databank Dementia eCohort, known as SAILDeC. A team from the University of Edinburgh, led by Dr Tim Wilkinson and Dr Christian Schnier, have developed a research cohort from routine healthcare records found in the SAIL Databank, a research databank containing routine healthcare and adminstrative records for the Welsh populace. The eCohort is derived from 1.2 million individuals who met the inclusion criteria, and of those, ~130,000 dementia cases throughout the data coverage have been identified. This represents the first UK research-ready disease cohort derived solely from routine healthcare records, which can be analysed in its own right or combined with other rich sources of cohort and routine data. It is thought that the technical components of creating the cohort, in terms of coding and initial analysis, could be the lead for future eCohort generation in other disease fields. These eCohorts could then be analysed within their specific area of science, or combined for a rich multi-morbidity database. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact This is the first disease-specific eCohort of patients to be created from ~20 years of routine healthcare data. It provides a rich dementia-specific resource for episodic progression of patients with initial MCI through to mortality, and every stage in between. The process of creating the cohort can inform the creation of such cohorts from the SAIL source and other routine clinical data sources in many disease areas. 
 
Title iPSC resource for researchers 
Description iPSC resources available are listed on DPUK website where they can download iPSC directory provides the opportunity for researchers to formally request over 100 stem cell lines derived from healthy and diseased individuals 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Valuable way for researchers to find out about available resource 
URL https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso...
 
Description AMYPAD 
Organisation Amyloid Imaging to Prevent Alzheimer's Disease
Country European Union (EU) 
Sector Public 
PI Contribution JMS is UCL lead for AMYPAD at UCL - which has interdependencies with DPUK through EPAD
Collaborator Contribution Design of protocols
Impact Project recently commenced
Start Year 2016
 
Description ASAP SynTau: Alignment and Standardization of Neuroimaging Methods in Atypical Parkinsonism, specifically Synucleinopathies and Tauopathie 
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND)
Country European Union (EU) 
Sector Public 
PI Contribution This Working Group brings together neuroimaging experts from all over the world to develop a broad, community-based consensus on imaging protocols. These outcomes will help pave the way for the integration of neuroimaging in large and longitudinal multi-centre studies in AP, including therapeutic trials. Meetings, harmonisation of imaging data, workshops, and later data sharing.
Collaborator Contribution Meetings, harmonisation of imaging data, workshops, and later data sharing.
Impact A project initiation report is submitted to JPND. Data sharing agreements are in progress.
Start Year 2016
 
Description Abeta functional assays 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution We have worked to develop improved in vitro analysis odf Abeta function
Collaborator Contribution Collaborative development of assay
Impact Ongoing collaboration
Start Year 2015
 
Description BRACE 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution advice and training on genomic data analysis
Collaborator Contribution Investigating the genetic overlap between AD and other diseases or traits using polygenic risk scores in Avon Longitudinal Study of Parents and Children (ALSPAC)
Impact 1. Application of newly developed methodology (MR-Base), which hallows to do rapid high-throughput analysis of potentially interesting traits and environmental exposures. 2. Test for shared genetic susceptibility between AD and early life lipid levels, glycaemic, anthropometric, behavioral and cognitive traits in ALSPAC children
Start Year 2016
 
Description BioFIND - JPND 
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND)
Country European Union (EU) 
Sector Public 
PI Contribution We led the JPND award on the use of MEG in harmonisation and standarisation for Dementia research, bringing together Pharma and Academic partners from ten sites.
Collaborator Contribution Expertise, knowledge sharing, and scoping of future project needs.
Impact A project initiation report is submitted. A new data sharing project has begun across six sites.
Start Year 2016
 
Description Cambridge 7T consortium 
Organisation Medical Research Council (MRC)
Department MRC Cognition and Brain Sciences Unit
Country United Kingdom 
Sector Public 
PI Contribution Forming the new University-MRC partnership and Cambridge 7T consortium. Full access to new facility for both partners.
Collaborator Contribution Staff allocation for physics support and adjunctive technologies for participant interaction.
Impact Multidisciplinary - dementia, neurology, psychiatry, development and ageing, cognitive neuroscience and physics. New head of 7T department has been recruited.
Start Year 2015
 
Description Collaboration with Eisai AiM Institute 
Organisation Eisai Inc
PI Contribution Consultancy on Polygenic risk score for clinical trials
Collaborator Contribution We are in the process of negotiations
Impact potentially this collaboration will pay for a time of a postdoctoral researcher
Start Year 2018
 
Description Collaboratiuon with European Bioinformatics institute 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution We plan to provide a software for polygenic risk score calculation and prosess the GWAS summary statistics for all current GWASes available in EBI GWAS catalogue
Collaborator Contribution provide data access to the GWAS catalogue
Impact This collaboration will provide the GWAS processed data to the research community for quick and efficient calculation of polygenic risk score for any disorder (stored in the EBI GWAS catalogue)
Start Year 2019
 
Description DPUK 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Steering Group member, DPUK work package lead.
Collaborator Contribution Creating Dementia Platform UK Data Portal
Impact In the process of creating on-line database with dementia cohorts, available in the UK and pipelines for data analyses. Multidisceplinary: genetics, bioinfirmatics, IT.
Start Year 2014
 
Description DPUK Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Optimisation of high-content imaging protocols with Opera Phenix imager
Collaborator Contribution The ARUK Stem Cell Research Centre, Cambridge has standardised the use of the Opera Phenix and Nanostring Sprint instruments for QC in iPSC reprogramming and cproduction of cortical neurons. The Phenix is used for high-throughput imaging of pluripotency markers in patient-derived lines that are generated at the centre. The lab has established a method for routine characterisation of cortical neuron productions using the Nanostring digital gene expression platform. This will facilitate harmonisation of protocols between DPUK centres, and within the STEMBANCC consortium. The imaging platform has been used to develop methods for production of human microglia from iPSCs, and to study cell biology in patient iPSC-derived microglia, focussing on TREM2 mutatiosn. In collaboration with Talisman Therapeutics and AstraZeneca, assays have been established to measure protein uptake in cortical neurons by live imaging.
Impact Development of a strong Dementia Stem Cell Network in DPUK
Start Year 2016
 
Description DPUK DSCN 
Organisation Cardiff University
Department School of Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University College London
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Cambridge
Department Gurdon Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Public 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Manchester
Department Manchester Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK Data Discovery Tools Categorisation and Coding Programme 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide data from our cohort
Collaborator Contribution Create Data discovery tool
Impact Still ongoing
Start Year 2018
 
Description DPUK Imaging Consortium 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Public 
PI Contribution Sharing of Imaging protocols and data management structures
Collaborator Contribution N/A
Impact Project recently commenced
Start Year 2016
 
Description DPUK industry partnership 
Organisation Araclon Biotech
Country Spain 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation AstraZeneca
Department AZ Medimmune
Country United Kingdom 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation GlaxoSmithKline (GSK)
Department Neurology and GI Centre of Excellence for Drug Discovery (CEDD) GSK
Country United Kingdom 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation Ixico
Country United Kingdom 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation Janssen Research & Development
Country Global 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DPUK industry partnership 
Organisation SomaLogic
Country United States 
Sector Private 
PI Contribution The Dementias Platform UK provides a research infrastructure for developing new treatments for dementia
Collaborator Contribution Expertise and technologies
Impact Please refer to the following link: http://brain.oxfordjournals.org/content/138/12/3673
Start Year 2014
 
Description DSG (Data Study Group) Network 
Organisation Alan Turing Institute
Country Unknown 
Sector Academic/University 
PI Contribution A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts.
Collaborator Contribution Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop
Impact Newly active March 2019
Start Year 2019
 
Description DSG (Data Study Group) Network 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution A joint collaboration with the Turing Institue for using the DPUK Data Portal for Workshop - Machine learning - Data Portal infrastructure across DPUK population cohorts.
Collaborator Contribution Provision of the data workshop infrastructure - DPUK Data Portal and joint hosting of workshop
Impact Newly active March 2019
Start Year 2019
 
Description Dementias Platform UK Stem Cell Partnership 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Public 
PI Contribution OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network
Collaborator Contribution Members will share expertise and stem cell lines as part of DPUK Stem Cell Network
Impact Ongoing
Start Year 2016
 
Description Dementias Platform UK Stem Cell Partnership 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network
Collaborator Contribution Members will share expertise and stem cell lines as part of DPUK Stem Cell Network
Impact Ongoing
Start Year 2016
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation McGill University
Department Montreal Neurological Institute and Hospital
Country Canada 
Sector Hospitals 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation University of Bologna
Department Department of Neurologial Sciences
Country Italy 
Sector Academic/University 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation University of Göttingen
Country Germany 
Sector Academic/University 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description ETH Zurich - Oxford collaboration for functional imaging in a rodent model of Parkinson's disease 
Organisation ETH Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution Richard Wade-Martin's lab has engineered the rodent model of Parkinson's disease (human SCA overexpression). This model has been characterized with histology, voltammetry of dopamine release in cell culture, and behaviourally. In collaboration with the Zurich group, Johannes Klein has performed data analysis on the imaging provided by ETH Zurich.
Collaborator Contribution Oxford does not currently have the ability to perform high-quality resting state MRI in small animals. Our collaboration partners at ETH of acquired the imaging data, performed pre-processing with motion correction and ICA data cleaning. Together, we have analysed differences in brain networks between mice overexpressing human alpha-synuclein, and alpha-synuclein knockout siblings.
Impact The research is ongoing. The imaging data will be published in the coming year.
Start Year 2015
 
Description Enhancing autophagy flux in Parkinson's disease 
Organisation AstraZeneca
Department Astra Zeneca
Country United States 
Sector Private 
PI Contribution OPDC test drug like molecules in cellular models of Parkinson's
Collaborator Contribution Astra Zeneca to provide drug-like small molecules.
Impact Ongoing
Start Year 2016
 
Description European Prevention of Alzheimers disease project (EPAD) 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution DPUK is contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study
Collaborator Contribution European colleagues are also contributing towards the trials infrastructure and recruitment tot he EPAD longitudinal cohort study
Impact Multi-disciplinary: clinicians, imagers, geneticists, statisticians, epidemiologists.
Start Year 2016
 
Description Evaluation of selected CSF proteins as prognostic markers of dementia in patients with Parkinson's disease 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Provision of samples from our cohort
Collaborator Contribution Measuring two serum proteins (haptoglobin and homocysteine), as well as two cerebrospinal fluid proteins (Aß1-42 and phospho-tau).
Impact Ongoing research
Start Year 2016
 
Description Free living walking behaviour in a cohort of people with RBD 
Organisation Newcastle University
Department Institute of Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution applying the Axivity Device to RBD and Control participants attending Discovery clinic and providing clinical data
Collaborator Contribution Further analysis of data to look for evidence of the onset of motor-symptoms.
Impact Ongoing research
Start Year 2016
 
Description GW4 fellowship 
Organisation Cardiff University
Department Brain Research Imaging Centre (CUBRIC)
Country United Kingdom 
Sector Academic/University 
PI Contribution co-supervisor; advice and training on genomic data analysis
Collaborator Contribution A researcher, Judith Harrison
Impact To explore disease pathways in Alzheimer's disease using MRI Biomarkers and Polygenic Scores
Start Year 2017
 
Description Gothenberg CSF projects 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution Sharing of samples
Collaborator Contribution Assays
Impact A number of papers and also training of laboratory staff
Start Year 2012
 
Description Innovate UK 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Consultancy
Collaborator Contribution Design of Alzhemer's disease chip
Impact In the process of designing of Alzhemer's disease SNP array. Multidisceplinary: medical genetics, bioinformatics, statistics
Start Year 2015
 
Description Insight 46 
Organisation Medical Research Council (MRC)
Department MRC Cognition and Brain Sciences Unit
Country United Kingdom 
Sector Public 
PI Contribution Collaborating with colleagues at the UCL MRC National Survey for Health and Development, Institute of Molecular Neuroscience, and Institute of Nuclear Medicine, Insight 46 is a major prospective two-time point (0, 12m) MRI, amyloid PET, clinical, biomarker and neuropsychological study of 500 members of the MRC National Survey for Health and Development 1946 birth cohort. This highly inter-disciplinary study involving UCL based epidemiologists, neurologists, imagers, clinical chemists, geneticists and statisticians aims to determine the earliest biomarker changes of AD, the contribution of genetic and life course influences on the development of late life cognitive impairment, and the optimal means of designing AD prevention studies. This >£5M project includes funding from ARUK, MRC Dementias Platform UK (WP4), Wolfson Foundation and Brain Research Trust, as well as industry contributions (~£850K, Eli Lilly). As well as coordinating the project (with Fox, Richards) I supervise a study manager, two clinical PhD students (Lane and Parker, a Wellcome Training Fellowship), and a study coordinator. The study is well underway, with >300 scaned; cross-sectional data will complete in October 2017; and longitudinal collection two years later.
Collaborator Contribution N/A
Impact N/A
Start Year 2014
 
Description JPND EUFIND - European Ultrahigh Field Imaging Biomarkers for Dementia 
Organisation EU Joint Programme - Neurodegenerative Disease Research (JPND)
Country European Union (EU) 
Sector Public 
PI Contribution An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. We have contributed expertise, data, and engaged in a pilot study for feasibility and methods development
Collaborator Contribution An international consortium for harmonisation and standardisation of UHF-MRI for Dementia Research. Our partners from 20 EU sites have contributed expertise, data, and engaged in a pilot study for feasibility and methods development
Impact A project initiation report is submitted to JPND
Start Year 2016
 
Description Janssen NV Funding Uplift 2018/19 
Organisation Johnson & Johnson
Department Janssen Pharmaceutica
Country Global 
Sector Private 
PI Contribution DPUK Oxford provide project management and financial management for projects supported as part of this partnership
Collaborator Contribution As well as supporting the project through financial contributions Janssen are actively involved in collaborative research associated with DPUK projects.
Impact Publications arising will be reported by project leads
Start Year 2014
 
Description Lysosomal dysfunction and glycosphingolipid dysregulation in Parkinson's 
Organisation University of Oxford
Department Department of Pharmacology
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided serum samples from our cohort
Collaborator Contribution analyse serum/plasma and CSF from PD patients, at-­risk patients and control cases as our aims are to characterise the pattern of expression of GSLs in PD and to search for lipid biomarkers
Impact Ongoing research
Start Year 2016
 
Description MRC fellowship 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution advice and training on genomic data analysis
Collaborator Contribution A researcher, Dr. Emma Anderson, who is a highly productive junior researcher
Impact 1. To improve causal inference in mendelian randomization studies of dementia 2. To improve understanding of the genetic risk for dementia and trajectories of cognitive capabilities in aging 3. To identify modifiable risk factors that are related to dementia and cognitive decline
Start Year 2016
 
Description Misplaced in space 
Organisation University of East Anglia
Country United Kingdom 
Sector Academic/University 
PI Contribution Development of PE concept, and data sharing.
Collaborator Contribution Artistic development of a Dementia outreach exhibition
Impact Exhibition in 2017 at the University of East Anglia
Start Year 2016
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Alzheimer's Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation AstraZeneca
Department Astra Zeneca
Country United States 
Sector Private 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Johnson & Johnson
Department Janssen Pharmaceuticals
Country United States 
Sector Private 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description NTAD new therapeutics in Alzheimer's disease 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution DPUK EM theme
Collaborator Contribution New biomarker platform for dementia - Cambridge, Oxford, Janssen, JnJ, Lilly, AZ, ARUK and DPUK -
Impact Annual workshop
Start Year 2017
 
Description Neurochip Task Force Genetics Study 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution All study members to genotype their cohort on same chip
Collaborator Contribution Sharing genomic data between cohorts with OPDC and Centre PD
Impact Still active
Start Year 2018
 
Description Neurochip Task Force Genetics Study 
Organisation University of Luxembourg
Department Faculty of Science, Technology and Communication
Country Luxembourg 
Sector Academic/University 
PI Contribution All study members to genotype their cohort on same chip
Collaborator Contribution Sharing genomic data between cohorts with OPDC and Centre PD
Impact Still active
Start Year 2018
 
Description ODDI Phenotypic drug discovery in Parkinson's 
Organisation University of Oxford
Department Alzheimer's Research UK Oxford Drug Discovery Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Collaborative drug discovery project in Parkinson's
Collaborator Contribution Collaborative drug discovery project in Parkinson's
Impact Ongoing
Start Year 2017
 
Description Oxford collaboration for molecular imaging (PET) in a rodent model of Parkinson's disease. 
Organisation University of Oxford
Department Department of Oncology
Country United Kingdom 
Sector Academic/University 
PI Contribution Richard Wade-Martins' lab has engineered rodent models of Parkinson's disease: LRRK2 BAC transgenic rats expressing human wild-type, G2019S, or R1441C LRRK2 mutations. These models have been extensively characterised using behavioural tests, voltammetry, electrophysiological recordings and immunohistochemistry analyses, showing that transgenic rats aged 18-21 months bearing any of the LRRK2 mutations exhibit L-DOPA responsive motor dysfunction, impaired striatal dopamine release, and cognitive deficits, but with no apparent neurodegeneration or protein accumulation on histology. In collaboration with the Imaging Core at the Oncology Department, we have optimised a scanning protocol for the aged rat-cohorts that will allow the acquisition of 18F-DOPA PET data to further characterise the effect of these mutations on dopamine metabolism, and validate these rodent models for future imaging studies. The aim is to provide early imaging readouts for the response to therapy with candidate compounds in an animal model of the early stages of PD.
Collaborator Contribution This collaboration allows us to bring new methods to OPDC. Our collaborators provide the radiotracers needed to perform our molecular imaging studies (fluorodopa is not routinely produced or distributed), and the facilities and expertise to run our scans. Veronique Gouverneur's lab has pioneered a new synthesis route for fluorodopa, and they are currently working to scale it up to production level for us. Sean Smart and Veerle Kersemans run the PET facility at the Oncology Department and have optimised the imaging logistics, and helped with acquisition protocols and data reconstruction so we are able to scan our aging cohorts in time.
Impact Initial pilot studies have been performed to detect and address imaging-specific problems before starting the analysis of the transgenic cohorts. The dose and injection timing of aromatic amino acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT) inhibitors (benserazide and entacapone respectively), have been optimised to avoid fluorodopa metabolism outside the brain. The dose of radiotracer and scanning timings are currently under investigation with further pilot scans. We will start imaging the transgenic cohorts at the beginning of 2018, and we anticipate to complete data acquisition and analysis by the end of the year. With the outputs generated from this research, we will be able to apply for further funding to advance our use of molecular imaging for model characterisation and, in the future, for studies evaluating promising candidate compounds to modify disease progression.
Start Year 2016
 
Description Oxford collaboration for molecular imaging (PET) in a rodent model of Parkinson's disease. 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Richard Wade-Martins' lab has engineered rodent models of Parkinson's disease: LRRK2 BAC transgenic rats expressing human wild-type, G2019S, or R1441C LRRK2 mutations. These models have been extensively characterised using behavioural tests, voltammetry, electrophysiological recordings and immunohistochemistry analyses, showing that transgenic rats aged 18-21 months bearing any of the LRRK2 mutations exhibit L-DOPA responsive motor dysfunction, impaired striatal dopamine release, and cognitive deficits, but with no apparent neurodegeneration or protein accumulation on histology. In collaboration with the Imaging Core at the Oncology Department, we have optimised a scanning protocol for the aged rat-cohorts that will allow the acquisition of 18F-DOPA PET data to further characterise the effect of these mutations on dopamine metabolism, and validate these rodent models for future imaging studies. The aim is to provide early imaging readouts for the response to therapy with candidate compounds in an animal model of the early stages of PD.
Collaborator Contribution This collaboration allows us to bring new methods to OPDC. Our collaborators provide the radiotracers needed to perform our molecular imaging studies (fluorodopa is not routinely produced or distributed), and the facilities and expertise to run our scans. Veronique Gouverneur's lab has pioneered a new synthesis route for fluorodopa, and they are currently working to scale it up to production level for us. Sean Smart and Veerle Kersemans run the PET facility at the Oncology Department and have optimised the imaging logistics, and helped with acquisition protocols and data reconstruction so we are able to scan our aging cohorts in time.
Impact Initial pilot studies have been performed to detect and address imaging-specific problems before starting the analysis of the transgenic cohorts. The dose and injection timing of aromatic amino acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT) inhibitors (benserazide and entacapone respectively), have been optimised to avoid fluorodopa metabolism outside the brain. The dose of radiotracer and scanning timings are currently under investigation with further pilot scans. We will start imaging the transgenic cohorts at the beginning of 2018, and we anticipate to complete data acquisition and analysis by the end of the year. With the outputs generated from this research, we will be able to apply for further funding to advance our use of molecular imaging for model characterisation and, in the future, for studies evaluating promising candidate compounds to modify disease progression.
Start Year 2016
 
Description PSP network 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation Progressive Supranuclear Palsy Association (PSPA)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description PSP network 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution A new netwrok to coordinate clinical and genetic and imaging research of this severe neurodegenerative disorder
Collaborator Contribution 1. coordinated recruitment 2. biomarker development
Impact PPI acivities; Papers pending;
Start Year 2015
 
Description R4VAD 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution A DPUK meeting Oxford in January 2016 RE: stem cells, models and human studies lead to applications to TSA/BHF/AS Vascular Dementia call resulting in the 3 funded projects, one of them being Human (R4VAD), with Prof Joana Wardlaw leading c£1.2M.
Collaborator Contribution Leadership on the project and academic expertise.
Impact Too early to report significant outputs or outcomes at present.
Start Year 2016
 
Description Rodent fMRI imaging 
Organisation ETH Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution OPDC provides mouse models of Parkinson's
Collaborator Contribution ETH carries out fMRI scanning on mice
Impact Ongoing project
Start Year 2016
 
Description SerCymru Fellowship 
Organisation Government of Wales
Country United Kingdom 
Sector Public 
PI Contribution Supervising a Research Fellow. Project title: Deconvoluting the dementia phenotype using functional genomics and computational approaches
Collaborator Contribution Funding the project
Impact This is a multidisciplinary collaboration between biological sciences and informatics/statistic. We have gained assess to EBI data resources which will be analyzed within the scope of the project.
Start Year 2017
 
Description Structural and functional connectivity in the human basal ganglia in health and disease using high resolution MRI at 7T 
Organisation University of Oxford
Department Nuffield Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution FMRIB scans and clinical data from our cohort
Collaborator Contribution Investigate in vivo connectivity of human basal ganglia.
Impact Ongoing research
Start Year 2016
 
Description Synaptic Health 
Organisation Alzheimer's Research UK
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation AstraZeneca
Department AZ Medimmune
Country United Kingdom 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Eli Lilly & Company Ltd
Country United Kingdom 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation Janssen Biotech, Inc.
Country United States 
Sector Private 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Public 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description Synaptic Health 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Academic leadership and skills in new Dementia research platform; planning and applying for new funding; several meeting and phone conferences; about to initiate NTAD in Cambridge; planning of NTAD study;
Collaborator Contribution Expertise in translational neuroscience; planning; meetings; application for further funding;
Impact New Therapeutics in Dementia consortium; an interdisciplinary research group of clinicians, cognitive scientists, informatics, pharmaceutical and drug development experts; phase 0 studies for "New Therapeutics in Alzheimer's Disease" and "Deep and Frequent Phenotyping" that are designed to optimise phase II studies of disease modifying therapies and additional opportunities for insights into disease pathogenesis; data collection, analyses and publications still pending;
Start Year 2015
 
Description T cell reactivity to alpha-synuclein 
Organisation Celgene
Country United States 
Sector Private 
PI Contribution Interaction with Celgene scientists on Parkinson's immuniology
Collaborator Contribution Mentorship of early career researcher
Impact New post-doc appointed
Start Year 2019
 
Description The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) 
Organisation Alan Turing Institute
Country Unknown 
Sector Academic/University 
PI Contribution Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup
Collaborator Contribution Provision of resources at DPUK Datathons
Impact Newly established March 2019
Start Year 2019
 
Description The Deep Dementia Phenotyping (DEMON) Network - committee member (SB) and strategic partner (DPUK JG and SB) 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Knowledge partner and network activities associated with the DPUK Datathons and DPUK Usergroup
Collaborator Contribution Provision of resources at DPUK Datathons
Impact Newly established March 2019
Start Year 2019
 
Description The genetic background of REM sleep behaviour disorder and its conversion to synucleinopathies. 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Providing DNA samples from our cohort
Collaborator Contribution Analsying with 2 plaforms using advanced genetic methods.They have already analysed about 500 RBD patients, 600 PD patients and about 1000 controls, with very encouraging results.
Impact Ongoing research
Start Year 2017
 
Description Twinning: Centre PD 
Organisation University of Luxembourg
Department Faculty of Science, Technology and Communication
Country Luxembourg 
Sector Academic/University 
PI Contribution OPDC will share information on clinical cohorts, stem cells and neuropathology
Collaborator Contribution Centre PD will share information on clinical cohorts, stem cells and neuropathology Centre PD worked with us on the EU Twinning grant to facilitate OPDC clinical data base move from Open Clinica to Red Cap System
Impact Ongoing
Start Year 2015
 
Description UK 7T MRI network 
Organisation Cardiff University
Department Brain Research Imaging Centre (CUBRIC)
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Glasgow
Department Institute of Neuroscience and Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Nottingham
Department School of Biomedical Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Description UK 7T MRI network 
Organisation University of Oxford
Department Oxford Centre for Functional MRI of the Brain (FMRIB)
Country United Kingdom 
Sector Academic/University 
PI Contribution establishing a new 7T imaging network, with new CRI funding and MRC Parntership grant
Collaborator Contribution establishing a new 7T imaging network, with new CRI funding
Impact A series of workshops and symposia, for training, education and research exchange. Topics include 7T-Safety, fMRI, Parallel Transmit and research updates. The project is multi-disciplinary, between clinicians in neurology, psychiatry, radiology and physicists, engineers, and data informaticians.
Start Year 2016
 
Title Dementias Platform UK Data Portal 
Description The DPUK Data Portal is a platform to allow the ingress of data from cohort studies and real-world evidence data from across the UK and internationally. The Portal allows access, subject to data provider approval, to said data via an integrated application system, and provides an analysis environment on remote desktop to allow distributed team science from anywhere in the world. The Portal environment comprises of front end user tools, a virtual desktop infrastructure for data analysis, a security system for permissions management and data upload, and an underlying architecture of substantial storage and applications to support the data needs. 
Type Of Technology Webtool/Application 
Year Produced 2017 
Impact To date (early 2019) we have had ~80 applications for cohort data via our new processes. Of these, 50 have been approved and at least 25 studies are underway with analysis of their approved cohort data. All of these studies are contributing to the dementia research community with a mixture of traditional epidemiological hypotheses, methodology validation, complex machine learning, and statistical modelling all being achieved in the Portal. Website: https://portal.dementiasplatform.uk 
 
Title POLARIS 
Description We developed a novel approach to genetic set-based analysis and polygenic risk scoring, which accounts for linkage disequilibrium between SNPs and informs the analysis with previously reported effect sizes of a SNP's association to disease. We call this method POLARIS: POlygenic Linkage disequilibrium-Adjusted RIsk Score. 
Type Of Technology Software 
Year Produced 2017 
Open Source License? Yes  
Impact NA 
URL https://github.com/BakerEA/POLARIS
 
Description 26 April 2016, DPUK Annual Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact DPUK Open Day
Year(s) Of Engagement Activity 2016
URL http://www.dementiasplatform.uk/wp-content/uploads/2016/06/Conference-Programme.pdf
 
Description Organised talk by Cohort Lead at DPUK's host institution, University of Oxford 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Professor Marcus Richards, professor of Psychology in Epidemiology at UCL, senior researcher in NHSD cohort, and DPUK workpackage lead, delivered a talk at the University of Oxford's Department of Psychiatry.

His talk was entitled 'Life course antecedents of cognitive reserve and dementia risk'

The seminar space was full, with people standing in the back, indicating a keen interest in epidemiology, data science, AD and DPUK's work in facilitating progress in these areas.
Year(s) Of Engagement Activity 2018
 
Description Participation in an activity, workshop or similar - Poster presentation at CTAD conference, Barcelona 24-27th October 2018: Child adversity 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation: Using the power of Dementias Platform UK (DPUK) cohorts to investigate the longitudinal effects of childhood adversity on adult cognition and health outcomes: Implications for cognitive change & dementia outcomes. Interest and discussion in our research and further work which will involve further cohorts and a publication.
Year(s) Of Engagement Activity 2018
URL http://www.ctad-alzheimer.com/
 
Description "The Funny Side of Parkinson's" 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact "The Funny Side of Parkinson's" on BBC1. Paul Mayhew-Archer Documentary.
Richard Wade-Martins and Fahd Baig appeared to talk about OPDC.
Paul was named best presenter at the Grierson Awards for this documentary.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/iplayer/episode/b072xkcz/inside-out-south-parkinsons-the-funny-side
 
Description #DementiaActionWeek2018 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sharing content to promote #DementiaActionWeek2018 including producing original video of researcher
Year(s) Of Engagement Activity 2018
URL https://twitter.com/WadeMartinsLab/status/999632001920651264
 
Description 11/5/18 - Swansea University HDR UK & NHS Digital Data Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Discussion to enable mutual understanding
List of areas to explore for improvement & areas for development
Year(s) Of Engagement Activity 2018
 
Description 11th UK-Korea Neuroscience Symposium - Busan, Korea 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact An invited oral presentation of a paper co-authored with John Gallacher describing a DPUK cross-cohort analysis utilising multiple DPUK cohorts. An additional poster was also presented. The research was titled: 'Using the power of Dementias Platform UK (DPUK) cohorts to investigate the effects of childhood adversity on adult behvaioural, physiological, cognitive and dementia outcomes: A cross-cohort investigation'. Questions and further discussions about the analysis and DPUK were initiated as a result of both presentation and network opportunities are to be followed up from these presentations. Furthermore, interest in the DPUK portal was initiated.
Year(s) Of Engagement Activity 2018
URL https://www.ukorea.ac.uk/events/11th-uk-korea-neuroscience-symposium-20th-21st-august-2018-haeundae-...
 
Description 1946 70th birthday event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The 70th Birthday Event celebrated the 70th birthday of participants in the MRC NSHD (1946 birth cohort) - we provided a display of brain imaging
Year(s) Of Engagement Activity 2016
 
Description 2/10/18 - Technology Sector Symposium - Developing a UK Wide Health Data Research Platform 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The primary aim of the symposium is to brief potential platform partners on the DIH programme and interest them in the opportunity to work with us to develop it. This will be achieved by:
• Informing the technology sector of the aims of the Digital Innovation Hub programme as part of the Industrial Strategy Challenge Fund
• Establishing the mutual benefits to patients, the NHS, researchers and innovators
• Welcoming industry participation in co-development of the research platform
• Defining key requirements for successful delivery of the Digital Innovation Hub platform
• Facilitating collaboration across industry/academia/NHS to support this delivery
Year(s) Of Engagement Activity 2018
 
Description 2017 Research Dementia Research Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Talk to present progress and development in the DPUK and how the Platform can create opportunity.
Year(s) Of Engagement Activity 2015,2017
 
Description 2018 article published on iPS research in Oxford in Phenotype (Oxford Biochemical society magazine) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A decade of IPS cell research in Oxford by Sally Cowley
Phenotype is the magazine of the Oxford University Biochemical Society. It is run by students and staff and published on a termly basis.
Year(s) Of Engagement Activity 2018
URL https://issuu.com/phenotypejournal/docs/mt18
 
Description 2018/19 OPDC Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We produced a newsletter on OPDC activities.
This was sent to all study participants, those on OPDC news mailing list and will be handed out at events.
Year(s) Of Engagement Activity 2018,2019
URL https://www.opdc.ox.ac.uk/_asset/file/opdc2018-19-newsletter.pdf
 
Description 29-30/5/18 - International Clinical Phenomics Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact International, expert workshop, hosted by UK Biobank, to discuss the challenges of accurate identification and sub-phenotyping of multiple health-related outcomes at scale in large population-based prospective studies.
Year(s) Of Engagement Activity 2018
 
Description 5-7 October 2016, CCNA ISAB (Vancouver)(premanifest disease & cognitive footprint?) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary lecture at Canadian consortium on Neurodegeneration and aging
Year(s) Of Engagement Activity 2016
 
Description 5/9/18 - Design Thinking Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact As we develop the blueprint for the platform components of the Digital Innovation Hub programme, a one day design workshop as an opportunity for us to focus on the research experience we would ideally like from this platform. A highly interactive session led by experienced design thinking practitioners.
Year(s) Of Engagement Activity 2018
 
Description 6-7 April 2016, DZNE (Bonn)"The role of genetic cohorts in bridging clinical and basic science" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussion of the role of Genetic cohorts to advise the German Neurodegenerative disease research network
Year(s) Of Engagement Activity 2016
 
Description @dementiasuk twitter account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Our twitter account is used primarily to promote DPUK opportunities (training, funding and resources) amongst the dementia research community, and to engage with current issues in dementia research.
Year(s) Of Engagement Activity 2014,2015,2016,2017,2018
URL https://twitter.com/DementiasUK
 
Description A moving target? Dementia in changing older populations (and a changing world) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A talk was given at AAIC 2016 (Alzheimer's Association International Conference) 23-28 July at Toronto Canada.
Year(s) Of Engagement Activity 2016
 
Description A population perspective on dementia and its relationship with ageing and dying across time 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited speaker at Brocher foundation, Geneva, 14-15 April 2016. The redefinition of Alzheimer's disease and its social and ethical consequences.
Year(s) Of Engagement Activity 2016
 
Description A public health researcher's reflections on ethics informed consent our directin of travel and population studies of brain ageing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Up to date Alzheimer Disease researcher thinking from clinical and biomedical standpoints.
Year(s) Of Engagement Activity 2015
 
Description A-Level workshop in the Oxford Natural History museum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A-Level workshop in the Oxford Natural History museum March 2017 Naiara Demnitz
Year(s) Of Engagement Activity 2017
 
Description AAIC 2017 - Dementias Platform UK Showcase presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk from several DPUK work packages on the component products and research ongoing as part of the Data Portal setup
Year(s) Of Engagement Activity 2017
URL https://portal.dementiasplatform.uk
 
Description AAIC 2017 DPUK quick-fire symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Theme: Public Health and Psychosocial

Session Title: Focused Topic Session: The Dementias Platform UK Informatics Infrastructure: A Live-Fire Exercise

Session Overview: The DPUK informatics infrastructure is the most comprehensive set of data access and management tools available to dementia research, covering cohort data, EHR linkage, imaging, wearables and genetics. It also provides access to a depth and breadth of data that cannot be found elsewhere. This feature research session will showcase the various components of the platform using live-online examples to demonstrate its ease and flexibility of use.

Learning Objectives:
• Describe the range of DPUK informatics tools available to the research community
• Demonstrate the range of DPUK informatics tools available to the research community
• Illustrate opportunities for international collaboration using DPUK informatics tools
Slot: Wednesday, July 19, 2017: 2:00 PM-3:30 PM
Year(s) Of Engagement Activity 2017
 
Description ARUK Network Open Morning 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact About 150-200 people attended a morning of talks from Oxford researchers, including presentations on using stem cells in dementia research.
Year(s) Of Engagement Activity 2015,2016
 
Description ARUK Oxford network dementia information event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Open day of talks and information stands organised by Alzheimer's UK Oxford Research Network at John Radcliffe Hospital.
Talk by Sana Suri on Brain-Heart links
Year(s) Of Engagement Activity 2018,2019
URL https://www.oxdare.ox.ac.uk/public-events
 
Description ARUK Roundtable 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I have been invited and participated in a Roundtable discussion organized by Alzheimer's Research UK: "Where now for Alzheimer's disease research? Learning from recent clinical trials failures and planning for the future", 19 January, 2017
Year(s) Of Engagement Activity 2017
 
Description ARUK Technical Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Collaborative workshop to discuss the technical infrastructure of data sharing platforms, including DPUK to facilitate targeted treatments and research. Outcomes have resulted in collaborative networks, invitation to join steering committee, future workshop hosting (DPUK Data Portal), co-hosting of Datathons with ARUK-Turing, collaboration on a grant application and intellectual sharing of ideas.
Year(s) Of Engagement Activity 2018
 
Description ARUK YouTube Channel 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact You tube channel for Alzhiemer's Research UK Oxford network centre. Includes talks from open days, panel discussions and short Q&A videos.
Year(s) Of Engagement Activity 2015,2017,2018
URL https://www.youtube.com/channel/UCU_wr013kmYXypvNCRzU3JA
 
Description ARUK conference 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact Lots of questions

More interest in taking part in dementia research
Year(s) Of Engagement Activity 2015
 
Description ARUK/BRC Oxford Dementia Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact a day of talks celebrating the exciting research in the region including updates on some of the exciting big dementia research initiatives such as the ARUK Oxford Drug Discovery Institute, Dementia Platform UK, the NIHR Oxford Health Biomedical Research Centre and the Oxford Momentum Award. Accredited for 5 CPD credits.
Year(s) Of Engagement Activity 2017
URL https://www.dpag.ox.ac.uk/research/wade-martins-group/oxford-aruk-network-centre/research-day-2015
 
Description Academic Health Science Networks Webinar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Clare Mackay was invited to preset an AHSN Webinar in June 2017
Year(s) Of Engagement Activity 2017
URL http://atlas.ahsnnetwork.com/
 
Description Administrative Data Research Network Conference - Belfast, June 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A presentation on the DPUK Data Portal and the potential applications of Administrative Data and Linked Health Data
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description Alzheimer's Association International Conference (AAIC) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Present research at AAIC, which is the largest international meeting dedicated to advancing dementia science. The purpose is to disseminate our research and to learn about current and novel research in dementia science.
Year(s) Of Engagement Activity 2016
 
Description Alzheimer's Association International Conference (AAIC) Chicago 2018 (Computer Adaptive Testing) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster: Computer Adaptive Testing to Improve Mental Health Testing for Dementia-Focused Epidemiological Research: Bauermeister, S. & Gallacher, J.
Year(s) Of Engagement Activity 2018
 
Description Alzheimer's Association International Conference (AAIC) Chicago 2018 (DPUK Poster) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster: Dementias Platform UK (DPUK) Data Portal - World-leading infrastructure facilitating and supporting innovative Dementias research: Orton, C. et al., (presented on behalf of)
Year(s) Of Engagement Activity 2018
 
Description Alzheimer's Association International Conference (AAIC) Chicago 2018 (DPUK Talk) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation: Dementias Platform UK (DPUK) Data Portal: Bringing Researchers to Data & Using the Power of Cohorts.
Talk given at the preconference for AAIC PIA DADA group.
Year(s) Of Engagement Activity 2018
 
Description Alzheimer's Association International Conference (AAIC) Chicago 2018 (Ontologies) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster: A New Generation Ontology for Cross-Cohort Dementia-Focused Epidemiological Research: Bauermeister, S. & Gallacher, J.
Year(s) Of Engagement Activity 2018
 
Description Alzheimer's Association International Conference (AAIC) London 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentation: Item Response Theory (IRT) for improving efficiency and reliability of scale delivery, and analysis in epidemiological research: Bauermeister, S. & Gallacher, J.
Year(s) Of Engagement Activity 2017
 
Description Alzheimer's Research UK Conference - London - Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster on the Data Portal was presented and substantial interest developed over the day of its presentation.
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description Alzheimer's Research UK Conference 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Poster presentation: The MRC DPUK Data Portal: Bringing Researchers to Data: The Research Journey: Bauermeister, S, Gallacher, J. et al.
Year(s) Of Engagement Activity 2017
 
Description Alzheimer's Society debate: How can we beat dementia in the next twenty years 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Organised by the Alzheimer's Society. this involved patients, carers, supporters and the media who have had subsequent interest in research. very positive feedback from the Alzheimer's Society who were grateful for the input.
Year(s) Of Engagement Activity 2016
 
Description An invited interview at the Alzheimer's Research UK (ARUK) 2019 the Video Journal of Dementia 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact An interview for Video Journal of Dementia
Year(s) Of Engagement Activity 2019
URL http://www.vjdementia.com
 
Description An invited interview on issues facing researchers in Brexit for the Cross Party Group on Medical Research for Alzheimer's Society, UK 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Have provided an opinion on issues facing researchers in Brexit for the Cross Party Group in the Welsh Assembly looking at Medical Research
Year(s) Of Engagement Activity 2018
 
Description Annual meeting of Organization for Human Brain Mapping (OHBM), Vancouver 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Vaanathi Sundaresan:Poster: "Modelling white matter hyperintensities distribution within a population using Bayesian Inference." Eniko Zsoldos: Poster: 'Mid-life composite measures of biological aging predict structural integrity measures in later life'. Johannes Klein Poster "Prefrontal network dysfunction in prodromal and manifest Parkinson's disease"
Year(s) Of Engagement Activity 2017
 
Description Annual report 2017 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact The annual report summarised key areas of progress in Dementias Platform UK in 2017.
Year(s) Of Engagement Activity 2017
URL https://www.dementiasplatform.uk/about/annual-report-2017
 
Description Anti-Microbial Resistance Databank collaboration meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact An invite to present the DPUK Data Portal as an exemplar use case of the UK Secure eResearch Platform, to a group interested in using the infrastructure.
Year(s) Of Engagement Activity 2017
URL https://portal.dementiasplatform.uk
 
Description Article in daily mail featuring DPUK study 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Principal Investigator of the Deep and Frequent Phenotyping (DFP) study was interviewed by the Daily Mail. The article stressed the importance of studies like DFP which will help researchers develop treatments at the early stages in the development of Alzheimer's disease. This raised the importance of this type of work amongst the general public.
Year(s) Of Engagement Activity 2018
URL http://www.dailymail.co.uk/health/article-5437893/Could-anti-stress-drug-help-beat-Alzheimers
 
Description AstraZeneca drug libraries article on DPUK website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Article on Astra Zeneca Drug library screening on DPUK website accessible in the "For Researchers" tab then "Our Research Communities"
Facilitated by DPUK, scientists at the University of Oxford are investigating the behaviour of drugs developed by AstraZeneca (AZ) on patient-specific cell models. They are looking to see if they can be used to target a range of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.
Year(s) Of Engagement Activity 2018,2019
URL https://www.dementiasplatform.uk/our-impact/repurposing-drug-libraries
 
Description Attend Parkinson's UK engagement event at St James' Palace, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Attend reception at St James' Palace to raise awareness for Parkinson's disease
Year(s) Of Engagement Activity 2018
 
Description BBC Horizon - filming 2015-16 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC Horizon were interested in making a programme about Alzheimer's disease with a focus on novel technology - especially imaging - for early diagnosis and trials.
Several meetings were held with the produced and his team and then several days of on-site filming including following a research subject.
The film is due to be shown in Spring 2016 as a one hour long programme which is likely to reach an audience of more than a million
Year(s) Of Engagement Activity 2015,2016
 
Description BBC One Saturday Breakfast News - Funny Side of Parkinson's 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Richard Wade-Martins appeared on BBC One Saturday Breakfast News with Paul Mayhew-Archer to discuss our research using stem cell technology to grow and study dopamine neurons from skin cells.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/health-35734888
 
Description BBC Wales 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact I have given an interview for BBC Wales, broadcasted 20 April 2017
Year(s) Of Engagement Activity 2017
 
Description BBC radio 'World at One' mini-series 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A two-part mini series on the Deep and Frequent Phenotyping study (one of the DPUK work packages) was broadcast on BBC radio 4's World at One programme and on the BBC world service. The series profiled the scientists' work, setting out the importance of participation in dementia research studies and the current focus on early stage trials for dementia.
Year(s) Of Engagement Activity 2017
URL https://soundcloud.com/user-172249820/world-at-one-26-27-june-2017
 
Description Big Data - next big thing: evaluation. Presentation to 1st NHS Wales Digital Health and Care Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited talk on the future of health informatics and 'Big Data' for the NHS. The purpose was to demonstrate what was already happening, how evaluations of numerous interventions were being carried out using multi-sectoral data linkage, how this was also supporting DiscoverY Science and the potential for these activities to grow into normal practice for the NHS and wider public services.
Year(s) Of Engagement Activity 2017
 
Description Blog by Bryan Ng on DPUK website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on DPhil student Bryan Ng's project in Richard Wade-Martins' lab.
Disease-in-a-dish studies open a window to a new level of detail in dementia
Year(s) Of Engagement Activity 2019
URL https://www.dementiasplatform.uk/blog/disease-in-a-dish-studies-open-a-window-to-a-new-level-of-deta...
 
Description Booth at Alzheimer's Association International conference 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Visitors to the DPUK booth at the AAIC conference were able to learn more about DPUK's free resources for researchers through DPUK staff and scientists, literature and practical demonstrations of the Data Portal. The principal impact was awareness raising of DPUK's resources and funding amongst key users (the researchers) and other funders in the dementia research sector.
Year(s) Of Engagement Activity 2017
URL https://www.dementiasplatform.uk/upcoming-events/aaic-2017
 
Description Brain Health/Biomarker Panelist at BIOMED Conference 2018, Tel Aviv 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A key point for discussion in the overall Brain Health track was that there is abundant opportunity for us to discover new ways to treat brain disease, and in particular age-related dementias. Tapping into this potential, however, will require better ways of diagnosing, distinguishing, characterising and tracking dementias so that we can understand better which patients we are trying to treat, and how to target their particular set of biological and behavioural phenotypes. In this context, we will be asking the "Getting Closer to Validated Biomarkers" panel to explore where we are now, where we need to be, and how to get there.

Each panellist spoke for 5-10 minutes on any aspect of this topic. John's fellow panelists were Prof Nir Giladi, a clinical and research specialist in Parkinson's and movement disorders (please see quick biography from the Michael J Fox Foundation website https://www.michaeljfox.org/foundation/researchers.php?id=924) and Mike Irizarry, a senior leader in Eli Lilly's neuroscience group with medical and academic experience in Alzheimer's and other dementias and in public health.

This involvement developed relationships with key industry contacts in the UK dementia landscape (eg the DDF) and lead to several enquiries from industry colleagues about how they could collaborate with DPUK.
Year(s) Of Engagement Activity 2018
URL http://kenes-exhibitions.com/biomed/
 
Description Brains for Dementia Research Study Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on the use of BDR data on the DPUK Data Portal to the cohort study panel
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description British NeuroPsychiatric Association Annual meeting 24th February - medalist Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussion of nosological challanges in Dementia
Year(s) Of Engagement Activity 2016,2017
URL http://bnpa.org.uk/wp-content/uploads/2017/02/BNPA-FINAL-PROGRAMME-2017.pdf
 
Description British Neuroscience Association Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Sana Suri: Talk: British Neuroscience Association Conference, Birmingham April 2017: "The APOE Paradox"
Year(s) Of Engagement Activity 2017
 
Description Cecilia (Heyne) Lee Pint of Science Public Engagement Talk, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Pint of Science Public Engagement Talk, Oxford, Autumn 2016 on using iPSC for modelling neurodegeneration
Year(s) Of Engagement Activity 2016
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Talk led to a lot of questions and discussion - for almost an hour after the event

A number of people expressed interest in taking part in research
Year(s) Of Engagement Activity 2014,2015
URL http://www.dementiasplatform.uk/event/cheltenham-science-festival/
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Hands-on experiments, the MakerShack, our brand new Cyber Zone, heartbeat art there was much to explore on site in 2018!

From stargazing, fun activity trails, family days and heated discussions in the Conversation Corner to a large animal dissection live on the Festival site, Cheltenham Science Festival offers science galore for all ages.

Dr Tara Caffrey took part in the day to talk about her research into Tau.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science
 
Description Clare Mackay talk - New developments in Parkinson's and Alzheimer's research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact OPDC's Imaging lead Professor Clare Mackay and Masud Husain, Professor of Neurology and Cognitive Neuroscience, spoke at a talk open to all about "New developments in Parkinson's and Alzheimer's research".

In this accessible and informative public talk they explored the latest research into the debilitating neurodegenerative disorders Alzheimer's and Parkinson's. They showed how cutting edge research is: increasing our knowledge of the mechanisms causing these disorders, offering the prospect of earlier diagnosis and supporting the development of potential new therapies to slow the progression of the disease.
The talk was filmed as is available to view online
Year(s) Of Engagement Activity 2018
URL https://youtu.be/WtmCPdTdmPc
 
Description Co-chair for a session at an ARUK workshop: tackling gaps in Developing Life-Changing Treatments for Dementia 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact A workshop on 15-16 May in London to critically evaluate the current gaps in progressing toward an effective therapeutic intervention, and develop tangible plans to resolve these gaps. We know that since the G8 summit in 2013, several initiatives and roadmaps have been developed to increase investment and global attention. However, reviews of progress and changes in the research landscape show key gaps that are not currently being addressed.

John co-chaired a session (alongside Nick Fox) called - How do we choose the right patients for proof-of-concept clinical trials?

This workshop strengthened relationships with key people involved in the dementia research landscape and influenced the design of the Great Minds clinical studies register in DPUK.
Year(s) Of Engagement Activity 2018
URL https://www.alzheimersresearchuk.org/
 
Description Comment on the Polygenic Hazard scores for AD study by Tan et al (2019), Brain 142; 460-470 for Alzforum 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact I have commented on a study which was covered on Alzforum about polygenic hazard scores for AD, and shared my opinion on their availability to the public.
Year(s) Of Engagement Activity 2019
URL https://www.alzforum.org/news/research-news/multi-gene-score-predicts-cognitive-decline-independentl...
 
Description Contributor to UKRI Infrastructure Roadmap Cohort workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact UK Research and Innovation (UKRI) has been requested by BEIS to develop a Research and Innovation Infrastructure Roadmap. The purpose of this is to highlight the current capabilities across the UK and to set out future infrastructure priorities.
While the Roadmap is not linked to a capital budget, the priority areas are likely to influence capital spending priorities for UK government as it moves towards the ambition of providing 2.4% of UK GDP for research and development by 2027 .

One of the infrastructure themes being developed is around population data for research. MRC is looking to hold a workshop to consult with leading experts to shape the development of two potential new cohorts this area: 1.Child to Early Adulthood Cohort 2.Early Diagnosis Cohort (from late 30s/early 40s).

Participants would be asked to bring their knowledge and experiences to actively support MRC in developing the outline cohorts described above:
• We would tap into your expertise to explore issues such as:
o Purpose
o Feasibility
o Setting(s)
o Sampling framework
o Design
o Biomedical, biosocial, environmental measures
o Governance and access
o Ethics & consent

In addition, to the refinement of the options, we will be seeking views on how such investments would contribute to the national and international landscape.
Year(s) Of Engagement Activity 2018
 
Description Creation of OPDC news mailing list 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact There is now an option on the OPDC website to sign up to an OPDC news mailing list. This is used to send out news of outreach events and updates on our publications.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/news-mailing-list
 
Description Creation of wademartinslab_oxford instgram account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Account for Wade-Martins lab for Molecular Neurodegeneration, University of Oxford to share news
Year(s) Of Engagement Activity 2018,2019
URL https://www.instagram.com/wademartinslab_oxford/
 
Description DPUK Annual Conference - Data Portal presentation session 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on the DPUK Data Portal at the DPUK Annual Conference
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description DPUK Annual Conference 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Poster presentation: Neuroticism and cognitive change: Longitudinal evidence from 14 013 UK Biobank participants: Bauermeister, S. & Gallacher, J.
Year(s) Of Engagement Activity 2017
 
Description DPUK Annual Conference 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Poster presentation: The effect of childhood adversity on adult behavioural, psychological, cognitive and health outcomes: A UK Biobank & DPUK cross-cohort investigation: Bauermeister, S. & Gallacher, J.
Year(s) Of Engagement Activity 2018
 
Description DPUK Annual Conference 2018: The power of cohorts 23 April 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Dementias Platform UK (DPUK) conference - a day-long event on 23 April this year in London - is focused on supporting use of the Data Portal, and demonstrating the wider work that will draw on its resource.

Researchers will be offered the chance to join practical workshops, learning alongside colleagues from a variety of sectors and contexts about what the Data Portal and other DPUK resources means for university researchers, and those working in industry in drug development. We are delighted to announce that the speakers at our annual conference 2018 are Professor Hugh Perry and Professor Miia Kivipelto.

By supporting as many researchers as possible to use the Data Portal, through both funding and ongoing training, DPUK hopes to increase the chances of generating new insights and accelerating our progress towards new treatments for dementia.
Sign up for your free place at the conference.

For more information please visit www.dementiasplatform.uk/forresearchers

Dementias Platform UK is a public-private partnership funded by the Medical Research Council. DPUK's partners - ten universities and six pharmaceutical companies - have joined forces with the aim of accelerating research towards effective treatment for dementia by improving access to data.

By bringing together records from over 40 different cohort studies - including brain scans, genetics and clinical records - DPUK is creating the world's richest source of people data for use in research and drug development for dementia. This free-to-access resource of cohort data is available for use by any bona fide researcher who is interested in investigating dementia, whether based within a university or industry context.

DPUK facilitates safe and secure access to this data through its Data Portal, enabling research and analyses at a scale that has not previously been possible for studies into dementia.

DPUK wishes to promote scientific research using cohort study data. It has an active programme of experimental medicine and funds research using cohort data.
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/conference-2018/programme-for-the-day
 
Description DPUK Annual Review 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Annual Review is a comprehensive 68-page publication featuring impact across DPUK's workstreams in 2018. It is available online and printed copies were sent to 200 people in industry, key funder organisations in the sector, collaborators, and research organisations in the dementia research landscape. The Annual Review has received very positive feedback from industry, in addition to a key funder organisation.
Year(s) Of Engagement Activity 2015,2016,2017,2018
URL https://www.dementiasplatform.uk/about/our-organisation#annual-review-2018
 
Description DPUK Cohort Collaboration Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact DPUK commissioned a cohort collaboration meeting to allow its network to facilitate cohort to cohort projects and to gain feedback on how DPUK can best support the science being already performed by cohorts and how to integrate this into the Data Portal.
Year(s) Of Engagement Activity 2016
 
Description DPUK Cohort Seminar 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A cohort working group convened by DPUK to gather cohort staff, including principal investigator's, data managers and researchers, to disseminate information about DPUK's various work packages. Main involvement surrounded the ongoing build and operation of the DPUK Data Portal and Informatics Network.
Year(s) Of Engagement Activity 2016
 
Description DPUK Cohort Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A meeting to discuss plans, Portal and general DPUK next steps, and gain advice from an expert panel of DPUK cohorts
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description DPUK Data Portal Live Demonstration 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A live demonstration of the operational DPUK Data Portal was given by Chris Orton, Data Project Manager for DPUK at Swansea University, at the DPUK Annual Scientific Meeting at the Royal College of Obstetricians and Gynaecologists, on 4th May 2017. The demonstration showed a live log-in of the system, including the security measures and services available to researchers.
Year(s) Of Engagement Activity 2017
URL https://portal.dementiasplatform.uk
 
Description DPUK Data Portal Workshop Presentation at the Analyst Seminar 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of the DPUK Data portal: An overview its usability, tools, cohorts and application process for analysts and researchers.
Year(s) Of Engagement Activity 2018
 
Description DPUK Data Portal Workshop Presentation at the DPUK Annual Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact An overview of the functionality of the DPUK Data Portal, how to Identify, Access and Analyse data on the Data Portal. The Outcome was an additional half hour of questions which resulted in a revised Q and A section on our DPUK website and also an increase in emailed enquiries about applying for cohort data.
Year(s) Of Engagement Activity 2018
 
Description DPUK Data Portal demonstration at the EMIF/DPUK Joint Conference, February 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The DPUK Data Portal was demonstrated to researchers and policy makers from both DPUK and EMIF at the EMIF/DPUK Joint Conference in Manchester on 23rd February 2017. The session was designed to give a live run-through of the Portal, its tools, and its analytic potential, which inspired questions and interaction from the research community present.
Year(s) Of Engagement Activity 2017
 
Description DPUK Infrastructure Presentation at the EMIF DPUK Joint Conference, February 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Simon Thompson, Head of IT for Swansea University Medical School, gave a talk on DPUK infrastructure at the EMIF/DPUK Joint Conference in Manchester on 23rd February 2017. The presentation outlined the completion of the infrastructure build and move to live operation of the DPUK Data Portal which had begun to provision data.
Year(s) Of Engagement Activity 2017
 
Description DPUK MRI-PET Imaging Network Launch 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact DPUK MRI-PET Imaging Network Launch - bringing awareness to the expertise and benefits of the DPUK colleagues in the Imaging Network, as well as the resource of the 7 scanners. Opening speech by former Chief Executive of the MRC. Engagement with current industry partners, enquiries from new industry colleagues.
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/upcoming-events/dpuk-imaging-network-launch
 
Description DPUK New Generation Ontology Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A workshop for discussing the ontologies and sharing knowledge and good practice for a future DPUK cross-cohort epidemiological focused ontology.
Year(s) Of Engagement Activity 2018
 
Description DPUK Next generation seminar: analytics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact This DPUK workshop was designed to raise awareness of the Data Portal and key DPUK cohorts amongst data scientists. The workshop fostered collaborative working and the development of new proposals for analysis in the Data Portal.
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/for-researchers/expert-communities-1/statisticians/next-generation-...
 
Description DPUK Presentation at the Internation Population Data Linkage Network Conference, Swansea, August 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A presentation was given on DPUK infrastructure and informatics work at the IPDLN Conference, hosted at Swansea University in August 2016. The presentation was in front of an audience of international researchers and policy makers and explained the UKSeRP architecture used by DPUK and the plans to integrate cohort data and enhance modality knowledge.
Year(s) Of Engagement Activity 2016
 
Description DPUK Stakeholders Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Raised awareness of use of stem cells in dementia research
Year(s) Of Engagement Activity 2015
 
Description DPUK Website feature iPSCs: a shared resource 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Information on iPSC labs on DPUK website accessible in the "For Researchers" tab then "Our Research Communities"
Year(s) Of Engagement Activity 2018,2019
URL https://www.dementiasplatform.uk/our-impact/ipscs-a-shared-resource
 
Description DPUK newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The DPUK newsletter communicates resources, data updates and funding opportunities for researchers and funders of dementia research.
Year(s) Of Engagement Activity 2014,2015,2016,2017,2018
URL https://www.dementiasplatform.uk/about/dpuk-newsletter-subscription-form
 
Description DPUK policies 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact DPUK policy documents set out the principles underpinning DPUK's work in a number of areas: DPUK publications; intellectual property; cost recovery; data curation; data management; and data access.
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/about/policies
 
Description DPUK researcher blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The DPUK researcher blog exists to showcase to the public the scientific activity in DPUK, prior to the reporting of key scientific findings. It exists to improve awareness of DPUK resources to researchers from a range of disciplines.
Year(s) Of Engagement Activity 2019
URL https://www.dementiasplatform.uk/blog
 
Description DPUK twitter account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Through twitter, DPUK connects with the wider dementia research landscape, including policymakers, researchers and other funder organisations. Impacts are increased traffic driven to the DPUK website and increased awareness of the resources that DPUK offers the dementia research community.
Year(s) Of Engagement Activity 2014,2015,2016,2017,2018
URL https://twitter.com/DementiasUK
 
Description Danish Dementia masterclass 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A whole day masterclass in Copenhagen for dementia specialists across Scandinavia.
I lecture, then the rest of the day in case based discussions, analysis and Q&A.
Year(s) Of Engagement Activity 2018
 
Description Datathon 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Researchers worked in teams to analyse cohort data from the Deep and Frequent Phenotyping pilot study. Outcomes were increased awareness of the Data Portal and DPUK's cohorts among a wider group of researchers.
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/news/datathon-for-dementia
 
Description Daybreak Lectures on issues around dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Phillippa Carling gave a brief overview of her work on drug discovery lab at ODDI, with some videos of some of their equipment.
Year(s) Of Engagement Activity 2018
 
Description Dementia Awareness Morning - Bryan Ng 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Bryan Ng helped out at a dementia awareness event at the John Radcliffe Hospital.
This was a morning of talks about research into dementia in and around Oxford and a chance for the public to meet researchers and find out about support services available for people living with dementia.
Year(s) Of Engagement Activity 2018
URL https://www.oxdare.ox.ac.uk/public-events
 
Description Dementia and Neurodegeneration Network Ireland (DNNI) Inaugural conference (30 November 2017) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact explore current research/future directions in the Dementia/Neurodegeneration field, effective funding models for research and the importance of interdisciplinary collaboration.
Year(s) Of Engagement Activity 2017
URL https://www.eventbrite.ie/e/dnni-conference-2017-tickets-37728733658#
 
Description Dementia and a Research Institute - Interview in the Sun Newspaper 5Oct15 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Publicity to promote the fact that 5p from each carrier bag bought would be donated to the Dementia Research Centre. This was the brainchild of Malcolm Walker (Iceland) with Nick Fox (DRC)
Year(s) Of Engagement Activity 2015
URL http://www.thesun.co.uk/sol/homepage/woman/health/health/6735025/5p-bags-could-help-combat-dementia....
 
Description Dementia and ageing brains: the clash of evidence, belief and policy in diagnosis and capacity to benefit in our ageing populations 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A talk was given on 21 September 2016 at the Preventing Overdiagnosis Conference in Barcelona
Year(s) Of Engagement Activity 2016
 
Description Dementia: Population and Public health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A talk was given for the visit of the DRI Direct on 19 Oct 2016 at University of Cambridge, IPH
Year(s) Of Engagement Activity 2016
 
Description Dementias Platform UK (DPUK) Scientific Symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The purpose of the Symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically looking at the main themes of Cohorts, Networks and Experimental Medicine.
Year(s) Of Engagement Activity 2015,2016
 
Description Dementias Platform UK (DPUK) scientific symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The purpose of this symposium was for all members of DPUK to come together to discuss and learn more about the scientific activity of the Platform, specifically look at the main themes of Cohorts, Networks and Experimental Medicine
Year(s) Of Engagement Activity 2015,2016,2017,2018
 
Description Dementias Platform UK annual conference 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Delegates of DPUK's 2017 annual conference learnt about the resources available to the scientific community and initial studies which were already making use of these resources. Attendees were able to attend live practical demonstrations of the Data Portal and other free resources. Key outcomes of the day were increased awareness of DPUK's resources amongst the community of researchers based in universities and industry.
Year(s) Of Engagement Activity 2017
URL https://www.dementiasplatform.uk/upcoming-events/event-1
 
Description Dementias Platform UK annual conference 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Delegates of DPUK's 2018 annual conference learnt about the resources available to the scientific community and initial studies which were already making use of these resources. Attendees were able to attend live practical workshops on the Data Portal. Key outcomes of the day were increased awareness of DPUK's resources amongst the community of researchers based in universities and industry.
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/conference-2018/programme-for-the-day
 
Description Dementias Platform UK website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The website provides general information about the DPUK project for the general public and policymakers, in addition to information for prospective industry partners in the project and an area for dementia researchers around the world to find out about the research tools and resources that are available to them through DPUK.
Year(s) Of Engagement Activity 2016,2017,2018
URL http://www.dementiasplatform.uk
 
Description Dementias Platform UK website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The website provides general information about the DPUK project for the general public and policymakers, in addition to information for prospective industry partners in the project and an area for dementia researchers around the world to find out about the research tools and resources that are available to them through DPUK. In 2018, there were 11,000 users of the DPUK website. Comparing the last quarter of 2018 with the last quarter of 2017, we see a 97% increase in users, demonstrating dramatically increased awareness of DPUK's offer.
Year(s) Of Engagement Activity 2014,2015,2016,2017,2018
URL http://www.dementiasplatform.uk
 
Description Discussant, 39th Edinburgh Clinical Neurology Course CPC 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact N/A
Year(s) Of Engagement Activity 2017
 
Description Downing Street 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Inivitation to attend reception at 10, Downing Street
Year(s) Of Engagement Activity 2017
 
Description EU Joint Programme - Neurodegenerative Disease Research, ADDITION Consortium Kick-off meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussion with the initial working group of the ADDITION Consortium, regarding the DPUK Data Portal supporting the research analysis.
Year(s) Of Engagement Activity 2019
URL https://portal.dementiasplatform.uk
 
Description Early Career Researcher workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Over 40 early career researchers from universities in the UK and further afield attended a half-day workshop where they learnt about DPUK's plans for support for early career researchers and were able to give feedback and input into those plans. They also received advice on how to make successful grant applications. Impacts are difficult to measure but can be considered to be increased awareness of DPUK resources and support amongst the early career researcher community.
Year(s) Of Engagement Activity 2017
URL https://www.dementiasplatform.uk/upcoming-events/ecr-workshop
 
Description Editorial from Tim Greenamyre on our paper on what's wrong with Mitochondria in Parkinson's 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Editorial in Movement Disorders Journal on our publication
Year(s) Of Engagement Activity 2018
URL https://www.ncbi.nlm.nih.gov/pubmed/30288798
 
Description European Brain Council Strategic Workshop (13 and 14 September 2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact EBC members and people working in the Value of Treatment White Paper. To explore new areas of project development for the EBC and the continuation of their Value of Treatment White Paper.
Year(s) Of Engagement Activity 2017
 
Description Fluid Biomarkers for AD. Educational Workshop. AAIC, London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2017
 
Description Geneva Aging Series 2017: 4th Edition on recent developments in cognitive aging: workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited oral presentation: Using advanced psychometric methodologies to analyse UK Biobank cognitive and mental health data, and utilising DPUK platform data.
Year(s) Of Engagement Activity 2017
 
Description Global Alzheimer's Disease Data Iniative - Interoperability Working Group, Toronto, December 2018 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presence and interaction at the 1st Global AD Data Initiative Interoperability Working Group - discussing integrating worldwide AD data platforms.
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description Global Alzheimer's Disease Data Iniative - Interoperability Working Group, Washington, March 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attendance, presentation, and interaction at the 2nd Global AD Data Initiative Interoperability Working Group. Presentation of project plans and ideas to stakeholders, and involvement on debate and discussion surrounding development of initiatives.
Year(s) Of Engagement Activity 2019
URL https://portal.dementiasplatform.uk
 
Description Gordon Research Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Nora Bengoa-Vergniory "Mass-spectrometry approach highlights REST as a potential neuroprotective target for Parkinson's disease in an alpha synuclein overexpressing BAC-transgenic mouse model" Oral presentation Posters: Nora Bengoa-Vergniory, Dayne Beccano-Kelly, Natalie Connor-Robson, Rebecca Wallings
Year(s) Of Engagement Activity 2017
URL https://www.grc.org/parkinson-s-disease-conference/2017/
 
Description Great Minds - by invitation targeted website and blogs 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Built a targeted website as part of the Great Minds pilot. AIRWAVE cohort team collaborated with us on a pilot to approach 500 of their participants and invite them to join a clinical studies register (through a paper newsletter) which will help accelerate improvements in dementia research. 45 out of 500 participants have registered their interest to be part of clinical studies and trials for dementia as part of Great Minds.
Year(s) Of Engagement Activity 2019
URL https://www.greatmindsfordementia.uk/
 
Description Guest speaker at Alzheimer's Society Dementia Cafe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Sana Suri - Talk: guest speaker at Alzheimer's Society Dementia Cafe, Oxford September 2017: "The heart-brain link in dementia"
Year(s) Of Engagement Activity 2017
 
Description Health Canal article based on HDAC4 paper 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Online news article on HDAC4 paper based on Parkinson's UK press release
Year(s) Of Engagement Activity 2018
URL https://www.healthcanal.com/brain-nerves/parkinson/247111-experimental-cancer-drug-shows-promise-for...
 
Description Health Data Research UK Site Meeting - January 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation and discussion of the DPUK Data Portal as an affiliate partner of Health Data Research UK.
Year(s) Of Engagement Activity 2019
URL https://portal.dementiasplatform.uk
 
Description Hosted 'Brain Banking at scale: A DPUK Next Generation Workshop' 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Post mortem examination provides the most accurate method available for obtaining accurate dementia diagnosis. Well characterised brains, those with detailed contextual data, provide greater opportunity for new insights to be gained on the causes of dementia. DPUK cohorts provide a reservoir of highly informative brains with up to 60 years lead-in data and genotyping being available. A DPUK actuarial analysis has shown that during the next 10 years an estimate of 6,500 brains with donor consent and the support of surviving family from UK Biobank alone, is not unreasonable. DPUK has already developed a consent protocol for selective brain collection, but is not aware of consensus on how to cost-effectively collect brain tissue at scale. To consider how to collect brain tissue at scale we invited several dementia research leaders in London for a one day workshop. During the day, participants representing a range of disciplines were given an opportunity to suggest the donor selection criteria, tissue type, and collection and storage requirements they would find most informative. From this, consensus on a strategy that might be implemented.
Year(s) Of Engagement Activity 2018
URL https://www.dementiasplatform.uk/upcoming-events/brain-banking-at-scale
 
Description Hughes - CBU Open Science Workshop 2016, Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK (2016) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Hughes, L. (22nd November 2016). CBU Open Science Workshop 2016, Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Year(s) Of Engagement Activity 2016
 
Description IASIS: Big Data for Precision Medicine, Plenary Meeting, March 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Attendance and interaction at the IASIS plenary meeting. DPUK is supporting IASIS on data access and to discuss integration of the IASIS tools to the DPUK Data Portal. The tools comprise discovery tools, data subset selection mechanisms and data analysis pipelines. The two pilot use cases for the IASIS tools are analysis of dementia outcomes, and lung cancer.
Year(s) Of Engagement Activity 2019
URL http://project-iasis.eu/
 
Description IMI-EMIF Symposium Brussels 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster: Predictors of Successful Cognitive Aging in European Superagers (90+ Years): A Cross-Platform EMIF & DPUK Investigation of Real-World Evidence: Bauermeister et al. (Presented by Jansen, W.)
Year(s) Of Engagement Activity 2018
 
Description Informatics for Health 2017 - Showcasing of DPUK Portal at the Swansea University stand - 24/4/17-26/4/17 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Informatics for Health 2017 - Showcasing of DPUK Portal at the Swansea University stand - 24/4/17-26/4/17
Year(s) Of Engagement Activity 2017
 
Description Insight 46 launch facebook offices 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Talk sparked questions and included George Freeman MP - Minister for Life Sciences

A number of members of the audience asked for further information
Year(s) Of Engagement Activity 2015
 
Description Interactive workshop on "The Upside-down Brain" at the Ashmolean museum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Sat 18 March, All day
The Upside-Down Brain: Art and Neuroscience at the Ashmolean Family Friendly Event. Naiara Demnitz
Year(s) Of Engagement Activity 2017
URL https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwjE172jjO...
 
Description International Dominantly Inherited Alzheimer's Disease Family Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact N/A
Year(s) Of Engagement Activity 2017
 
Description International Population Data Linkage Network Conference - Banff, Canada, September 2018 - Data Services presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Laura North presented on the data curation and preparation services offered by DPUK to enhance cohort data usability and integrity.
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description International Population Data Linkage Network Conference - Banff, Canada, September 2018, Data Portal presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Infrastructure presentation on technical and data integration of the DPUK Data Portal
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description Interview in Civil Service Fast Stream blog - How Stem Cells Can Boost Our Knowledge and Understanding of the Causes of Dementia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This is the third and final in a series of interviews carried out by a group of civil servants that have dedicated time to raising money and awareness for dementia via 'The Fund', a Fast Stream initiative. Alison Leishman, Home Office, interviewed Professor Wade-Martins about his research into dementia.
Richard discussed OPDC and the DPUK.
Year(s) Of Engagement Activity 2016
URL https://faststream.blog.gov.uk/2016/05/20/the-fascinating-world-of-research/
 
Description Joint Programme for Neurodegenerative Disease (JPND) Scientific Advisory Board (SAB) strategic workshop on precision medicine (13 March 2017) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The purpose of the workshop is to bring together clinicians, basic scientists and industry scientists to examine how the precision/stratified medicine concept can be applied to neurodegenerative disease research.
Year(s) Of Engagement Activity 2017
 
Description Key note (debate) RCPsych Faculty of Neuropsychiatry conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2017
 
Description Large Clinical populatin based studies as sources for big datasets 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Was part of a conference and the session before mine was on imaging. This was a nice update on imaging work in Germany.
Year(s) Of Engagement Activity 2015
 
Description Late night event at The Science Museum 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Lecturing as part of Oxford University's MSc in Non-communicable diseases - neurodegenerative conditions with a focus on dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecturing as part of Oxford University's MSc in Non-communicable diseases - neurodegenerative conditions with a focus on dementia - asked to lecture at a Chinese university exchange summer school and engage more with life at the host college (St Edmunds Hall).
Year(s) Of Engagement Activity 2018
 
Description MS Society Public Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact A presentation to members of the MS Society
Year(s) Of Engagement Activity 2016
 
Description Mark Kelly Parkinson Voice Project lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Mark Kelly spoke at a Parkinson Voice Project lecture presented in the Clark and Brigid Lund Parkinson's Education Center. The talk was streamed live and is available online.

This lecture explores what we know so far about impulse control behaviours in Parkinson's and takes a look at work being carried out by the Oxford Discovery Project to better understand these effects. This knowledge helps not only in better directing available therapies, but also improves our understanding of some of the underlying pathological processes involved in Parkinson's.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/impulse-control-behaviours-and-creativity-in-parkinson-s
 
Description Medical Express article on HDAC4 paper 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on HDAC4 publication based on Parkinson's UK press release.

Medical Xpress is a web-based medical and health news service that is part of the renowned Science X network. Based on the years of experience as a Phys.org medical research channel, started in April 2011, Medical Xpress became a separate website.

Branching out with Phys.org's monthly 2.5 million readership, Medical Xpress features the most comprehensive coverage in medical research and health news in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.

Readers of Medical Xpress will have access to the same features offered on Phys.org, such as article comments, ranking, the ability to save favorite articles, a personal account page, easy sharing, podcasts, iPhone/iPad/Android apps and other options.

Readers may follow Medical Xpress on Facebook, Twitter or through a variety of customizable RSS feeds and e-Newsletter for the latest in medical research and health news.
Year(s) Of Engagement Activity 2018
URL https://medicalxpress.com/news/2018-12-experimental-cancer-drug-parkinson.html
 
Description Medicine and Me: Living well with Dementia 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Giving a talk on types and diagnosis of dementia at this half day meeting.

The Medicine and Me series of meetings at the RSM aim to update on important conditions and gives a direct voice to patients and their carers to air their concerns on the impact of diagnosis, investigation and management. Physicians and surgeons and indeed all healthcare professionals continue to learn from and be inspired to greater efforts by our patients to improve care.
The audience at this meeting will comprise of those living with dementia, their families, carers and advocates, representing about 70% of those present; and clinicians and researchers, representing not more than 30%. Clinicians will include doctors, specialist nurses and others involved in the treatment and care of those who have this condition
Year(s) Of Engagement Activity 2016
URL https://www.rsm.ac.uk/events/events-listing/2015-2016/groups/public-engagement-programme/mmg01-medic...
 
Description Meetings with Insight46 donors via ARUK 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Meeting with Insight46 donors via ARUK to discuss Insight46 and dementia research.
Year(s) Of Engagement Activity 2016
 
Description Member of the SAIL Scientific External Advisory Board and their meetings 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Involved in the discussions for DPUK as a strategic partner for SAIL, as well as a member of the closed external advisory group evaluating SAIL - reviewing its primary focuses, the current landscape its in, and international development.
Year(s) Of Engagement Activity 2018
URL https://saildatabank.com/
 
Description Member of the Scientific Advisory Board of the Bordeaux Population Health research center (BPH) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact John Gallacher was invited as part of a small panel to take part in a mid-term assessment of the BPH as part of a Scientific Advisory Board. The SAB tried to see where they are today, both for the BPH globally and for the different teams, and to offer his opinion and insights on the scientific strategy and his suggestions for evolutions for the new project. It involved reviewing both the overarching strategy as well as the work of individual research groups.

BPH is run by the Director Prof Carole DuFouil, an esteemed colleague of DPUK as PI of a collaborating cohort. This SAB meeting provided useful insight into the international landscape that DPUK could fit in as well as crystallising important working relationships.
Year(s) Of Engagement Activity 2018
URL https://www.bordeaux-population-health.center/en/
 
Description Member of the governance, design and delivery strategy groups for the MS Society 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Member of the governance, design and delivery strategy groups for the MS Society.
Year(s) Of Engagement Activity 2018
URL https://www.mssociety.org.uk/
 
Description Michele Hu - Talks to Oxford and Milton Keynes Parkinson's UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Michele Hu Talk to loacal Parkinson's UK branches
Year(s) Of Engagement Activity 2016,2017
 
Description NHS Digital Collaboration Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Meeting with NHS Digital to discuss infrastructure solutions for DPUK cohorts, and wider onward sharing to the UKSeRP infrastructure tenants.
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description NHS Lothian Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Clinical Research : driving efficient, innovative and effective healthcare.
Year(s) Of Engagement Activity 2016
 
Description Nature Neuroscience Interoperability Meeting, Toronto, December 2018 - Data Portal presentation and panel appearance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A technical presentation on the DPUK Data Portal, followed by an appearance on the data platform panel, answering policy and practice questions from an expert meeting audience
Year(s) Of Engagement Activity 2018
URL https://portal.dementiasplatform.uk
 
Description Nesbit - Talk presented at the meeting on "Your ageing brain. Use it or loose it". Meeting by Sevenoaks and Knole U3A Science Groups (2016) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Nesbit, D. (7th June, 2016). Talk presented at the meeting on "Your ageing brain. Use it or loose it". Meeting by Sevenoaks and Knole U3A Science Groups
Year(s) Of Engagement Activity 2016
 
Description Neurogune talks, Bilbao Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact "Alpha-synuclein overexpressing mice and protection of neurons from synuclein toxicity by molecular tweezers" Oral presentation Nora Bengoa-Vergniory
Year(s) Of Engagement Activity 2017
 
Description New Atlas online article on HDAC4 press release 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on HDAC4 paper based on the press release from Parkinson's UK
Year(s) Of Engagement Activity 2018
URL https://newatlas.com/experimental-cancer-drug-parkinsons/57481/
 
Description Nora Bengoa-Vergniory article on Celgene Fellowship 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Interviwe with Dr Nora Bengoa-Vergniory on her experience as a Celgene Fellow for the Oxford University Medical Sciences division website
Year(s) Of Engagement Activity 2018
URL https://www.medsci.ox.ac.uk/research/internal/funding-directory/oxford-celgene-fellowship/oxford-cel...
 
Description November 2016, WISH Summit (Qatar) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact -
Year(s) Of Engagement Activity 2016
 
Description OPDC Facebook Page 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Creation of OPDC Facebook page. Used to update on OPDC activity. Focus on outreach events, but also includes news about publications etc. Also used boosted posts to promote OPDC open day.
Year(s) Of Engagement Activity 2017,2018,2019
URL https://www.facebook.com/OxfordPDCentre/
 
Description OPDC Newsletter Summer 2017 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We have produced a 12 page newsletter with updates on our recent activities. This includes OPDC research news, outreach activities and news from members of the cohort and Parkinson's UK. The newsletter is posted to all cohort members and emailed to those on the news mailing list. It is also available online.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/newsletters
 
Description OPDC Open Day 2016 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact OPDC Open Day 2016
250 OPDC study Participants and Partners registered for event.
Day of talks from Michele Hu, Fahd Baig, Claudio Ruffmann, Tom Barber and Richard Wade-Martins.
Discussion of what participants would like from study.
Talks filmed and podcasts added to website
Year(s) Of Engagement Activity 2016
URL http://www.opdc.ox.ac.uk/openday2016
 
Description OPDC Open Day 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We held an afternoon of talks and invited members of our cohort, their supprters, and members of the Thames Valley Parkinson's UK Excellence Network to attend. Around 200 people registered for the event and the feedback was largey positive. We have moved to a larger venue out of the city centre to allow us to offer parking. Talks were filmed and are available on our website and YouTube channel. Speakers at the event were Michele Hu, Mark Kelly, James Cantley, Tom Barber, Christine Lo, Sally Cowley and Richard Wade-Martins.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/openday2017
 
Description OPDC Open Day talks online 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact A series of talks recorded at the 2018 OPDC Particpant's day are available to view on our YouTube channel and on our website.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/videos
 
Description OPDC Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The OPDC Research Day is a one-day event with research talks from world leading Parkinson's researchers on topics including clinical studies, imaging, genetics, proteomics, neuronal cells and animal models.
The 2017 OPDC Research Day was held in the Medical Sciences Teaching Centre, Oxford.
There was a full day of talks and poster sessions on Parkinson's research.
This one-day event included research talks by national and international keynote speakers and Oxford researchers on a range of Parkinson's work including clinical studies, imaging, genetics, proteomics, neuronal cell culture and animal models.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/research2017
 
Description OPDC Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact We held a research day to present an update on current Parkinson's research in the region and invited members of our SAB from overseas to present their work.
This was attended by researchers from accross Oxford as well as members of the local Parkinon's UK group and interested study participants.
We invited Hazel Stanyon, a study partiicpants who apoke about her experiences of how exercise has helped her Parkinson's symptoms and shared a poem.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/research2018
 
Description OPDC YouTube channel 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Creation of OPDC YouTube channel to collate our podcasts etc.
32 subscribers, >2,860 views Feb 2016-Jan 2017.
2016 talks >1,450 views,
2016 OPDC highlights video >350 views,
2015 talks >1,000 views
Year(s) Of Engagement Activity 2015,2016
URL http://www.youtube.com/channel/UCGzboizARwaAUFW5FjPmmZw
 
Description OPDC welcomes Participants to Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact On September 10th, 2018 over 200 members of Discovery cohort came to the Jury's Inn, Oxford to hear about our latest research and share their views. We would like to thank all of the cohort members who came to the event from our centres across the country, and joined in the lively discussion session.

Researchers from across OPDC's themes shared their work. These included talks on our work to develop a new test for Parkinson's, how we are using skin biopsy samples from our cohort to look for new potential therapies and new drugs trials on our horizon, our work to improve sleep studies, how we are working with other large studies of people with Parkinson's to better define Parkinson's and our work on dyskinesia. We also heard about a new survey to define top priorities for Parkinson's research and heard more about the brain donation process.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/opdc-welcomes-participants-to-open-day
 
Description Organised talk by a esteemed researcher at DPUK's host institution, University of Oxford 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Prof Carole DuFouil, Research Professor at the Bordeaux School of Public Health and PI of the MEMENTO cohort (a DPUK collaborating cohort), was invited to speak on 'Alzheimer's Disease biomarkers: a population perspective' at the Department of Psychiatry, University of Oxford. The seminar space was full, with people standing in the back, indicating a keen interest in epidemiology, data science, AD and DPUK's work in facilitating progress in these areas. Carole received several questions on the day as well as e-mail requests before and after the event.
Year(s) Of Engagement Activity 2018
 
Description Oxford Dementia Research Day 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Poster: The MRC DPUK Data Portal: Bringing Researchers to Data: The Research Journey: Bauermeister, S. & Gallacher, J.
Year(s) Of Engagement Activity 2018
 
Description Oxford PD UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact I spoke at a meeting of the Oxford Parkinson's UK branch
Year(s) Of Engagement Activity 2017
 
Description Oxford PD UK Carol Service and walk 2016 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Attended and supported Parkinson's UK Oxford Carol service and sponsored walk 2016
Year(s) Of Engagement Activity 2016
 
Description Oxford Science Festival Information Stand 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Oxford Science Festival, June 2016 (Clare MacKay manned a stand)
Year(s) Of Engagement Activity 2016
URL http://www.oxfordshiresciencefestival.com/
 
Description Oxford Sleep Study #OxfordAI video 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sleep study on wearable technology chosen by Oxford University team for a feature video as part of their OxfordAI series.
Coverage on Oxford University website, twitter and facebook feeds.
Year(s) Of Engagement Activity 2018
URL https://www.facebook.com/the.university.of.oxford/videos/2136127846704050/
 
Description Oxford Sparks'animation about the role of microglia in neurodegeneration 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Postdoc Hazel Roberts won Oxford Sparks' competition to have an animation made about the role of microglia in neurodegeneration. Title: Discovering life-changing dementia treatments.

Your beautiful, complex brain is a network of microscopic cells that connect together to form your thoughts and personality, and control your body. The network is fragile and requires constant upkeep, like a garden. The brain has its own gardeners, specialised cells called microglia. In this animation we look at how researchers at the University of Oxford are developing drug treatments for Alzheimer's disease, by harnessing the power of the brain's microglia.
Year(s) Of Engagement Activity 2018
URL https://www.oxfordsparks.ox.ac.uk/content/discovering-life-changing-dementia-treatments
 
Description Oxford University article on HDAC4 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on front page on Oxford University website based on HDAC4 pressrelease from parkinson's UK
Year(s) Of Engagement Activity 2018
URL http://www.ox.ac.uk/news/2018-11-30-experimental-cancer-drug-shows-promise-parkinson%E2%80%99s
 
Description Panel discussion: ISTAART careers in science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2017
 
Description Panel to review DPUK Great Minds in London - proving feedback on risk/consent of participating in dementia research 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Patient and Public Involvement working group for DPUK Great Minds, a clinical studies register. Discussed and got views on consent and risk data. Feedback has shaped how we provide information on a public website, and clarified our privacy policies.
Year(s) Of Engagement Activity 2018
URL https://www.greatmindsfordementia.uk/
 
Description Parkinson's Documentary - Kent University 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Richard Wade-Martins interview with Isabelle Miller, a journalist at the University of Kent for a documentary about young people who have Parkinson's (20s-30s).
To be produced Mar 2018

------

A bit more about the documentary:

It will be a 15-30 minute long-from television documentary.

A lot of people forget that it occurs in young people as well as older people, although less common. I want to educate people on how individual it really is, as well as raise awareness, therefore gaining more support. I also want people to see how a young person adapts their life to the condition.

Having Parkinson's at a working age is a whole different challenge compared to those who have it later in life. Some have to stop working, some are determined to continue and be a part of the ever-developing research.

I want to show people that, yes, it is difficult to live with Parkinson's, and research into YOPD needs to be funded further, however, I also want to show how people make life their own. It would be an insight into both the struggles and normalities people with Parkinson's face.

This is a topic which has light and shade for viewers and will serve a great purpose in informing those who need the information.
Year(s) Of Engagement Activity 2017,2018
 
Description Parkinson's Life online article on HDAC4 press release 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on research paper based on press relelase from Parkinson's UK
Year(s) Of Engagement Activity 2018
URL https://parkinsonslife.eu/repurposed-cancer-drug-parkinsons/
 
Description Parkinson's UK Blog Post on HDAC paper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Blog by Claire bale on Parkinson's UK Blog
Using brain cells grown from skin to find new potential drugs
Researchers in Oxford are using pioneering stem cell techniques to understand the earliest problems that occur inside brain cells in Parkinson's - and hunt down new drugs that can tackle them.
Year(s) Of Engagement Activity 2018
URL https://medium.com/parkinsons-uk/using-brain-cells-grown-from-skin-to-find-new-potential-drugs-78f56...
 
Description Parkinson's Walk 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Members of OPDC took part in the Oxford Parkinson's Walk. Melanie Witt and Jane Rumbold manned an information stand with literature about our work and sign up sheets for infomration about participating in research. Taking part were Michele Hu, Richard Wade-Martins, Sally Cowley, Paul Bolam, Amandine Louvel, Tom Barber, Ludovica Griffanti, Marie Crabbe, ChristineLo, Johannes Klein, Jane Rumbold, Charmaine Lang and Rebecca Wallings.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/opdc-joins-parkinson-s-uk-2017-oxford-walk
 
Description Participant at the International Cohorts Summit 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The International 100K Cohort Consortium (IHCC) was established in 2018 at the request of the leaders of the Heads of International Research Organizations (HIROs) through a collaboration between the Global Genomic Medicine Collaborative (G2MC) and the Global Alliance for Genomics and Health (GA4GH).

John was invited to contribute alongside the PIs of the most influential cohorts and their funders internationally to discuss:

? Improve prospects for interoperability and compatibility of instruments, data formats, phenotypic and clinical measures, etc.
? Promote data sharing and open access policies
? Broaden international cooperation through existing tools and resources
? Explore the feasibility of a "digital" platform, or web-based, evolving registry of large-scale cohorts, in searchable format
? Examine the potential for a collaborative sequencing (and other -omics?) strategy
? Consider strategies for translating findings for health impact
? Advance a collective vision: where do we want to be in ten years?
Year(s) Of Engagement Activity 2018
URL https://ihcc.g2mc.org/
 
Description Pete Magill welcomes Lord O'Shaughnessy, Parliamentary Under-Secretary of State for Health to OPDC & MRC BDNU 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact The Medical Research Council Brain Network Dynamics Unit at the University of Oxford recently welcomed Lord James O'Shaughnessy, Parliamentary Under-Secretary of State for Health, for a site visit organised as part of The Royal Society's Pairing Scheme that OPDC theme 3 co-lead Professor Pete Magill is taking part in.

The visit began with Unit Group Leaders Peter Brown, Peter Magill and Tim Denison highlighting why, how and where the Unit undertakes its cross-disciplinary research incorporating experimental neuroscience, clinical studies and bioengineering. This prompted some insightful discussion on the Unit's contribution to the UK's research and innovation landscape, as well as its alignment with government policy and strategy. Lord O'Shaughnessy then toured Unit facilities, and met with some of the Unit's early-career scientists who showcased the concepts and technologies underpinning their respective experiments. After lunch, Lord O'Shaughnessy visited Unit research collaborators at the Oxford Parkinson's Disease Centre and the ARUK Oxford Drug Discovery Institute.

Peter Magill commented, "Lord O'Shaughnessy's visit was an invaluable opportunity for us to engage and to be engaged. The mutual exchange of knowledge was both invigorating and enlightening. I can highly recommend the Pairing Scheme to other scientists and policymakers."
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/pete-magill-welcomes-lord-o-shaughnessy
 
Description Pharma partnerships under CDA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A series of six pharma partnership meetings related to PSP and FTD novel therapeutics, under CDA/NDA
Scoping the needs and opportunity, reviewing candidate product preclinical data, and developing better trial design,
Year(s) Of Engagement Activity 2018
 
Description Plenary Speaker at Clinical Trials in Alzheimer's Disease (CTAD) conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Plenary Speaker at European Academy of Neurology on Imaging Trials and Dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Plenary speaker: Cypriot Neurological Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2015
 
Description Plenary speaker: The neurology of ageing, ABN Annual Meeting, Brighton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2016
 
Description Population data and modelling: dementia as exemplar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A talk was given at the Cumberland initiative Festival of Evidence 5th of Oct 2016.
Year(s) Of Engagement Activity 2016
 
Description Poster at Advances in Neurodegenerative Disease Research and Therapy/New Frontiers in Neuroinflammation Keystone Conference, Colorado USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Nora Bengoa-Vergniory poster
"Tau-proximity ligation assay detects pathology ahead of tau neurofibrillary tangles in Alzheimer's disease"

As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.
Year(s) Of Engagement Activity 2018
URL http://www.keystonesymposia.org/18Z3
 
Description Poster presentation at CTAD conference, Barcelona 24-27th October 2018: Psychometric methodologies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poster presentaton of research work entitled: Psychometric methodologies to increase scale-reliability in dementia-focused epidemiology: Outcomes from the European Prevention of Alzheimer's Disease Study & UK Biobank. This work will be published in a peer reviewed journal at a later date. This work has gained great interest from the epidemiological community and further work in this field is planned as well as a grant application.
Year(s) Of Engagement Activity 2018
URL http://www.ctad-alzheimer.com/
 
Description Poster presentation at DPUK Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Outline presentation of work package 2 of DPUK, the informatics stream, at the time focusing on the build and purpose of the DPUK Data Portal. The poster featured a description of the envisaged tools, data management and planned activity for the coming year.
Year(s) Of Engagement Activity 2016
 
Description Presentation at Database Resources for Large-Scale and Complex Data workshop, Engineers' House, Bristol, 21st June 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Chris Orton presented on the DPUK use case of UKSeRP and the enhancement of cohort data and research that this brings to the epidemiological and general scientific community in the sphere of Dementia. The presentation detailed the infrastructure supporting advancement in multi-modal data use and how to harness disparate data from eclectic and valuable sources across the world within a centralised management and access system, whilst allowing data providers to retain governance of their data.
Year(s) Of Engagement Activity 2017
 
Description Presentation on Ageing Research for A-Level students at the UNIQ Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Presentation on Ageing Research for A-Level students at the UNIQ Summer School - https://www.psych.ox.ac.uk/team/naiara-demnitz
Year(s) Of Engagement Activity 2017
URL http://www.uniq.ox.ac.uk/
 
Description Presentation on DPUK as a use case of UKSeRP at the Administrative Data Research Network Conference, Royal Surgeon's Hall, Edinburgh, 1-2 June 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chris Orton, Data Project Manager for DPUK at Swansea University, presented on DPUK as a use case of UK Secure eResearch Platform at the ADRN Conference in Edinburgh on Friday 2nd June 2017. The presentation outlined the complex instance of UKSeRP that DPUK uses to host its infrastructure, namely the DPUK Data Portal, and also showed how this links to other national research organisations who are also making use of UKSeRP.
Year(s) Of Engagement Activity 2017