UKDP: Integrated DEmentiA research environment (IDEA)

Lead Research Organisation: Cardiff University
Department Name: School of Medicine

Abstract

The UK Dementias Platform (UKDP) is a radically new approach to dementias research. It brings together data from around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of slowing it down. The platform has been funded to the level of £12M.

In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of the opportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will put the UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together to make best use of the equipment.
The three themes of the proposal are imaging, informatics and stem cells.

For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processes going on inside the brain that cause dementia can be studied.

For informatics we want to be bring together bas many different types of data as possible and make it easy as possible for scientists to use them

For stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementias process begins and progresses.

We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, making the UK an internationally unique place to study dementia.

Technical Summary

Our objective is to achieve a step-change in UK dementia research capacity through establishing national networks of existing and emerging centres of excellence in imaging, informatics and cell-biology.

The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and cost-effective translational pipeline from discovery through to early phase trials. UKDP will create closer synergy between epidemiology and experimental medicine with the re-purposing of epidemiologic cohorts for trials readiness. The size and depth of phenotyping available to UKDP will deliver a step-change in the complexity and granularity of dementia related hypothesis testing and accelerate compound development.

Proposed here is an infrastructure of investment and collaboration. Underpinning UKDP is a critical mass of researchers and resources that will work together to encourage, facilitate, and develop a fully integrated dementia dedicated UK research environment. This will raise standards, reduce costs, and deliver innovative and coordinated research, to make the UK an internationally unique research environment. Through its partnership with major academic centres and industry, UKDP is well positioned to achieve this goal.

Building on the recent MRC investment in UKDP, we propose here to renew and extend the UKDP integrative research environment with an advanced molecular imaging network strategically located to exploit UKDP cohorts. Also proposed is an integrated informatics environment to facilitate the location of and access to both data and bio-samples. The third proposal is for a stem-cells network to promote the use of this important and emerging technology. Each of these elements adds value to existing infrastructure investments and fills significant gaps in the UK research landscape.

Planned Impact

The current proposal in in support of the UKDP and will become part of the the UKDP impact strategy.

In summary, the UKDP strategy to deliver pact is to develop networks of partnership to actively consult engage the UK academic community in relation to dementia research focussing on the direction,
technologies and collaborations of the UKDP and the wider UK national infrastructure.

Our aim is to:
1) promote the best possible science
2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.

Partnership discussions with industry are already underway with exchanges of ides, interests and needs between academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia cohorts and for experimental medicine studies to conform to regulatory requirements.

We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier interventions and better targeted treatment in general by health service providers and the public alike.

Engagement with the general public and with patients and carers is a very important part of our mission. This serves not only to communicate our research findings and their relevance but also to address such issues as stigma in society and the research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.

In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.

Publications

10 25 50
 
Description Academy Medical Sciences Council Member
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Academy Medical Sciences Fellow
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Academy Medical Sciences Wales Ambassador
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description COVID advisory group
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Deputy Director DPUK
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
 
Description EPAD LCS sample access committe
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Medicines Discovery Institute MDI
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description NMHRI management
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description National Core Studies
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact £7million funds for projects related to COVID: prediction, protection and prevention
 
Description ABBUK Brains for Dementia Research Programme (extension)
Amount £2,598,988 (GBP)
Organisation Alzheimer’s Brain Bank UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2021
 
Description Centre for Ageing and Dementia Research - 2 Year Extension
Amount £1,200,000 (GBP)
Funding ID 514840 
Organisation Government of Wales 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2020
 
Description Dementias Platform
Amount £6,618,190 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2014 
End 06/2019
 
Description European prevention of Alzheimer's dementia consortium
Amount £104,414 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2015 
End 12/2019
 
Description Expanding DPUK genetics and integrating with inflammation/immunity research
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2019
 
Description In vivo imaging of Tau distribution in the brain
Amount £44,743 (GBP)
Organisation Welsh Local Government Association 
Sector Public
Country United Kingdom
Start 01/2016 
End 03/2017
 
Description PERADES: Defining genetic, polygenic and environmental risk of Alzheimer's disease using multiple power cohorts, focussed epigentics and stem cell metabolomics
Amount £389,000 (GBP)
Funding ID ARUK-PG2014-1 
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2013 
End 11/2016
 
Description Powerful study of rare variants in Alzheimer's disease (R Sims)
Amount £200,000 (GBP)
Funding ID 164 
Organisation Alzheimer's Society 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2012 
End 02/2016
 
Description The development and implementation of polygenic risk algorithms for stratifying individuals for future cognitive decline due to Alzheimers disease
Amount £298,040 (GBP)
Funding ID 2018/20180222 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Therapeutic targeting of impaired lysosomal flux in Alzheimer's disease
Amount £136,502 (GBP)
Funding ID MR/P007651/1 
Organisation Network of Centres of Excellence in Neurodegeneration (COEN) 
Sector Public
Country United Kingdom
Start 08/2016 
End 10/2017
 
Title AD Genetics Scotland 
Description Blood samples are collected from participants and sent directly from research sites to European Collection of Authenticated Cell Cultures (ECACC), a Culture Collection of Public Health England. Upon arrival, ECACC process the blood and transform into cell lines- peripheral blood lymphocytes (PBLs) and Lymphoblastoid cell lines (LCLs). Cell lines are frozen and stored at ECACC until they are required by the team at Cardiff. 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact Ongoing collection of samples, no publications to date. 
 
Title DLB Genetics 
Description Blood samples are collected from participants and sent directly from research sites to European Collection of Authenticated Cell Cultures (ECACC), a Culture Collection of Public Health England. Upon arrival, ECACC process the blood and transform into cell lines- peripheral blood lymphocytes (PBLs) and Lymphoblastoid cell lines (LCLs). Cell lines are frozen and stored at ECACC until they are required by the team at Cardiff 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact Ongoing collection of samples, no publications to date 
 
Title Plcg2 animal models 
Description To establish a functional pipeline for the study of disease associated genes and polymorphism in microglia and MØ in the context of dementia-related disease in vivo. The initial concentration is on the impact of coding mutations of PLCG2. In parallel, studies were initated on SPI1 and ABI3. Large scale 'omic and functional assay data derived from these studies will be used to bioinformatically identify potential causative abnormalities, by association with patient data 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? No  
Impact n/a 
 
Title DPUK Genomics portal 
Description The DPUK Genetics portal provides a collaborative platform for individuals, DPUK cohorts and the wider research community to share and access research outputs from genetic research. The platform provides two key tools for finding, sharing and analysing genetic data; The Results Registry tool, accessible via the main DPUK web portal, allows searching and uploading of genetic results data. This tool provides a rich set of search tools specific to genetic data and includes visualisation using the popular JBrowse genomic browser. This tool will allow users to share this data. This can be done under secure data transfer agreements if necessary. The second tool is the Genetic Data Browser this is available exclusively within the secure DPUK infrastructure. This will allow users to create cross-cohort comparison studies based on genotypic datasets and linked phenotypic data. This tool provides an interactive dashboard which can pull in phenotypic data and genetic markers from GWAS data and allow users to intuitively explore, combine and export patient cohorts. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact The DPUK Genetics portal, housed on the DPUK platform, allows non bioinformatic-expert users to explore components of genetic data within a secure environment. We have provided access to an international consortium, GERAD, via the DPUK data portal. This is a dataset of over 18,000 cases and controls (detailed in Table 2), as well as over 5,600 samples to date submitted to the EADB, the European AD DNA bank for deciphering the missing heritability of Alzheimer's disease 
URL https://portal.dementiasplatform.uk/
 
Description ADES Collaboration 
Organisation Erasmus MC
Country Netherlands 
Sector Hospitals 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation Hospital de Sant Pau
Country Spain 
Sector Hospitals 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation Pasteur Institute, Lille
Country France 
Sector Charity/Non Profit 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation University of Bonn
Country Germany 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation University of Pennsylvania
Country United States 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description ADES Collaboration 
Organisation VU University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution A way to make aware our different institutions and funders of that we are working hard to a better organisation of the AD genetic field worldwide and we need strong support for this.
Collaborator Contribution as above
Impact n/a
Start Year 2016
 
Description Dementia Platform UK (DPUK) 
Organisation Department of Health Social Services and Public Safety (DHSSPS)
Country United Kingdom 
Sector Public 
PI Contribution Biostatistical analysis and epidemiological
Collaborator Contribution sample collections / cohorts, data and molecular biology
Impact none yet
Start Year 2014
 
Description PROTECT / CHARIOT-Pro / Cardiff DPUK 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform.
Collaborator Contribution DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping
Impact None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry
Start Year 2018
 
Description PROTECT / CHARIOT-Pro / Cardiff DPUK 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform.
Collaborator Contribution DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping
Impact None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry
Start Year 2018
 
Description PROTECT / CHARIOT-Pro / Cardiff DPUK 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Genotyping of 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be completed by Cardiff Univ as part of a collaboration funded by Dementias Platform UK. Polygenic risk scores will be calculated for these individuals and data made available via DPUK Platform.
Collaborator Contribution DNA samples from 1,000 research participants from the PROTECT (KCL & Exeter) and CHARIOT - Pro (Imperial) research studies will be sent to Cardiff Univ for genotyping
Impact None to date - work in progress. Collaboration is multi-disciplinary - Neurology, Neuroepidemiology & Ageing; Genetics & Genomics; Psychiatry
Start Year 2018
 
Description UK Biobank neurodenerative disease platform 
Organisation King's College London
Department NIHR Biomedical Research Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Named investigator on grant application
Collaborator Contribution co-investigators on grant application
Impact Grant application currently under review
Start Year 2013
 
Description UK Biobank neurodenerative disease platform 
Organisation University College London
Department Dementia Research Centre (DRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Named investigator on grant application
Collaborator Contribution co-investigators on grant application
Impact Grant application currently under review
Start Year 2013
 
Description UK Biobank neurodenerative disease platform 
Organisation University College London
Department Institute of Neurology
Country United Kingdom 
Sector Academic/University 
PI Contribution Named investigator on grant application
Collaborator Contribution co-investigators on grant application
Impact Grant application currently under review
Start Year 2013
 
Description UK Biobank neurodenerative disease platform 
Organisation University of Oxford
Department Department of Physiology, Anatomy and Genetics
Country United Kingdom 
Sector Academic/University 
PI Contribution Named investigator on grant application
Collaborator Contribution co-investigators on grant application
Impact Grant application currently under review
Start Year 2013
 
Title Dementia's Platform UK Biostatistics Tool 
Description Bespoke analysis tool to perform the latest analyses on the largest UK datasets available. 
Type Of Technology Software 
Year Produced 2016 
Impact Product still under development / improvement following user feedback. 
 
Title Dementia's Platform UK Cohort Selection Tool 
Description Used to select cohorts of interest, and to put a research proposal to them for feedback under the DPUK research protocol. 
Type Of Technology Webtool/Application 
Year Produced 2016 
Impact Improvements ongoing to develop impacts. 
URL http://www.dementiasplatform.uk/cohort-tools/
 
Description AAIC Los Angeles Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact MODEL-AD presentation - Alzheimer's Susceptibility Genes Implicate Microglial Activity
Year(s) Of Engagement Activity 2019
 
Description AMS fellowship workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Organisation of a Academy of Medical Science workshop by J Williams as Wales AMS Champion to encourage applications from young researchers to become AMS fellows
Year(s) Of Engagement Activity 2019
 
Description ARUK network 2019 Exeter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The event was organised between the ARUK Bristol & Bath, Southwest (Exeter and Plymouth) and Wales networks. The aim was for members to meet, showcase research & build collaborations. J Williams spoke on Research infrastructure and resources: UKDRI as member of Cardiff University and UK Brain Banks Network
Year(s) Of Engagement Activity 2019
 
Description Alzheimer's gene study achieves landmark breakthrough 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Cardiff University publicised publication in Nature Genetics "Genetic meta-analysis of diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing" - aiming to raise public awareness of research being undertaken at UK Dementia Research Institute Cardiff
Year(s) Of Engagement Activity 2019
 
Description BBC Wales evening news UK DRI Cardiff official opening 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Interview of Professor Julie Williams to publicise official opening of UK DRI Cardiff. Prof Williams explained the purpose of the DRI, its multi-targeted approach, and the funding that had enabled attraction of world class scientists to Cardiff.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/iplayer/episode/b0bp0k0t/bbc-wales-today-evening-news-25102018#
 
Description BBC radio interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Radio interview BBC Forty research groups led by scientists in Cardiff, France and the United States have been working more closely together and have now pooled a worldwide database of 90,000 samples. "We're about to submit a paper that is enormously exciting and which I think will really change, without a doubt, what we think of Alzheimer's disease going forward," Professor Julie Williams, head of the research team at Cardiff University, said. "Over the last five or six years we've been successful in identifying 30 genes that increase - or decrease - your risk for Alzheimer's disease. Now this is telling us what some of the major components in disease development are. It's new, it's exciting; it's a different perspective on what Alzheimer's disease is."
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/news/uk-wales-36286847
 
Description CURE ND Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Workshop to discuss disease models in the field of neurodegeneration, what are the most advanced models to date, how accurate are they, and what is missing in terms of modelling
Year(s) Of Engagement Activity 2021
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Festival theme 2019 was health and wellbeing, considering everything from the food we eat and our exercise regimes to cutting-edge medical research. As part of this theme, the event explored the latest breakthroughs in dementia research. The panel was asked to talk about the broad landscape in this field and its evolution in recent years, key achievements and challenges and an insight into how the diagnosis and treatment of dementia has changed and developed. J Williams talked about cutting-edge research and expertise and the exciting aspects of her own work within this area
As populations have aged, dementia has become the fifth biggest cause of death worldwide. Yet despite its devastating consequences there is currently no cure. What do we know about this group of diseases, and are there things we can do to help reduce our risks and keep our brains fighting fit? Alzheimer's disease specialist Julie Williams and psychiatrist Ivan Koychev discuss the latest breakthroughs and discoveries that are helping to prevent, diagnose and treat dementia more effectively.
Year(s) Of Engagement Activity 2011,2019
 
Description Insurance United Against Dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Alzheimer's Society Insurance United Against Dementia campaign dinner - aim to formally launch IUAD partners to senior figureheads from the insurance industry Used as an opportunity to thank existing IUAD partners and inspire potential partners to make a contribution.
Year(s) Of Engagement Activity 2019
 
Description Interview for national news 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Official opening of UK DRI Cardiff, attended by 300+ guests, including funders, Welsh government officials, members of the public taking part in dementia research studies, postgraduates. Widely publicised on national BBC and ITV news and radio
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/news/uk-wales-45942094
 
Description Interview for national news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview on national TV which is broadcast worldwide describing set up of Cardiff Univ receiving funding to set up as a UK dementia centre
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/news/uk-wales-south-east-wales-39646667
 
Description Interview for regional news 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Interview on regional news to discuss setting up of new DRI UK laboratories in Cardiff and work on dementia research
Year(s) Of Engagement Activity 2018
URL http://www.itv.com/news/wales/2017-04-20/dementia-centre-to-offer-step-change-in-research/
 
Description Keynote speech Sutcliffe Kerr Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Keynote speech at annual Walton Centre, Sutcliffe Kerr Lecture
Year(s) Of Engagement Activity 2019
 
Description Local news item on brain donation for dementia research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Older people in Wales are being urged to think about donating their brains after they die to help scientists researching dementia. This has sparked questions and debates - 80 comments within 24 hours. It will definitely influence people by raising awareness of the disease, the process of donation, benefits of donation/research and also opting in/out law change. We are confident this will increase the number of healthy/diseased donations and positively impact research field.
Year(s) Of Engagement Activity 2018
URL http://www.bbc.co.uk/news/uk-wales-43084710
 
Description MRC CNGG celebration event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact MRC CNGG celebration - presentation and video
Year(s) Of Engagement Activity 2019
 
Description Medical Women's Federation Spring Conference 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation on 'Finding the causes of Alzheimer's disease'
Year(s) Of Engagement Activity 2018
 
Description Quote for This is Wales publication 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Quotation provided on the subject of innovation in Wales for trade magazine, emphasising research focus on dementia, specifically Alzheimer's disease
Year(s) Of Engagement Activity 2018
 
Description RCPsych Neuropsychiatry Annual Conference 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk given to conference entitled "Neuropsychiatric Genetics of Dementia and other Neurodegenerative Disorders: Implications for treatment, prevention and personalised psychiatry"
Year(s) Of Engagement Activity 2019
 
Description Recorded interview ARUK conference March 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact An interview with Video Journal Dementia at ARUK Conference 2018 discussing work at Cardiff DRI UK - online publication aimed at healthcare professionals
Year(s) Of Engagement Activity 2018
URL https://vjdementia.com/speaker/julie-williams
 
Description Taking a new look at the risk factors for Alzheimer's disease 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Media article on publication of Multiplex Model in Nature Neuroscience - providing information on how the genes that have been identified as risk factors impact on other genes to trigger Alzheimer's
Year(s) Of Engagement Activity 2020
 
Description UK Korea Neuroscience Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact UKorea symposia bridge basic and clinical research within neuroscience. J Williams gave plenary lecture on 1st day 2019 symposium. The statements were shared via the UK-Korea social media channel (twitter @UKorea_Neuro).
Year(s) Of Engagement Activity 2019
 
Description Visit to DRI laboratories by Sir Venki Ramakrishnan 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Sir Venki Ramakrishnan, the President of the Royal Society visited DRI laboratories, Cardiff on 23rd October prior to giving a lecture organised by Welsh Government
Year(s) Of Engagement Activity 2019
 
Description Welsh Government workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact The Welsh Government held a UKRI "Strength in Places Fund" and potential for Wales workshop. Strength in Places (SIP) offers a significant funding opportunity and the University is keen to prepare a pipeline of projects for development in this area, in what is anticipated, to be an annual call.
Year(s) Of Engagement Activity 2019
 
Description Will members of my family develop Alzheimers disease?' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Dr Rebecca Sims presented "Will members of my family develop Alzheimer's disease?" at CADR Meeting Swansea, 2/8/2018. This reached an audience of 50 persons including general public, medical professionals, researchers and carers. This generated a number of questions and discussion after the talk, and was part of a wider discussion following other presentations focusing on similar topics.
Year(s) Of Engagement Activity 2018
 
Description Women in Industry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Presentation to Women in Industry event, providing overview of career, advice for women in STEM careers
Year(s) Of Engagement Activity 2019
 
Description Women in Science film 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Women in Science video as one of the interviewees / case studies.
Year(s) Of Engagement Activity 2019