Origins of learning difficulties and behaviour problems: from behavioural genetics to behavioural genomics.

Lead Research Organisation: King's College London
Department Name: Social Genetic and Dev Psychiatry Centre

Abstract

'Emerging adulthood', the phase of the life course between adolescence and full-fledged adulthood, is when young people transition to independence as they leave home and make their own way in the world; a vulnerable, pluripotent time that can be a 'tipping point' for life-long mental health problems. We will bring together genetic and genomic strategies in order to establish the genetic, environmental and developmental origins of cognitive and mental health problems in emerging adulthood.

Our sample is unique, consisting of members of twin pairs who have been assessed longitudinally since infancy as part of the Twins Early Development Study (TEDS), which has been continuously funded by MRC programme grants (G0901245, G0500079, G9424799) since 1995. This is the largest ever in-depth longitudinal twin study. The twin design can disentangle genetic from purely environmental influences, and the infancy-through-adolescence data, including genome-wide genotypes, offer a developmental framework that can identify behavioural, genetic and environmental risk/protective factors that predict good vs poor outcomes in emerging adulthood.

Our proposed research has two objectives:

Objective 1. Identify behavioural, genetic and environmental risk/protective factors that predict good vs poor outcomes in emerging adulthood. We will assess a UK-representative sample of 10,000 TEDS twins (5,000 pairs) at age 21 on a broad battery of cognitive functioning (e.g., literacy and numeracy), mental health (e.g., anxiety and well-being) and environmental measures (e.g., emotional support and life events) comparable to the batteries used in our previous 20 years of assessment, as well as new measures specific to emerging adulthood. This will allow us to bring the longitudinal, genetically sensitive dataset of TEDS to bear on cognitive and mental health problems in emerging adulthood in the context of normal development. We will also conduct genomic analyses using genome-wide genotyping of millions of DNA markers for 5,000 unrelated participants (one member of a twin pair) and for 2,500 non-identical twins of these individuals; these resources will enable cutting-edge genomic analyses based on DNA alone.

Objective 2. Identify predictors of good vs poor outcomes for individuals of low IQ in emerging adulthood. Diagnosed intellectual disability (<70 IQ) has received much attention in recent molecular genetics research, but little is known about low IQ (70-79 IQ), which is ten times more common and which also results in major personal and societal costs, especially during the tipping point of emerging adulthood in an increasingly technological world. For Objective 2, we will investigate the problems faced by young adults who are challenged cognitively as they make their own way in the world. Our work will yield the first genetically sensitive study of the effects of low IQ on adjustment in emerging adulthood, by assessing in person 600 TEDS individuals with 70-79 IQ scores at age 21 (members of 400 twin pairs with at least one low-IQ proband), co-twins from discordant pairs, and 200 controls. We will conduct intensive in-person interviews focused on the adaptive functioning and adjustment of these low-IQ individuals and their co-twins as they begin to make their way in a cognitively taxing adult world. Their outcomes will be compared to a representative control sample of 200 TEDS individuals assessed in the same way. In addition to describing outcomes for individuals with low IQ as they emerge into adulthood, we will use the twin design comparing identical and non-identical twins to investigate, for the first time, the genetic and environmental origins of these outcomes of low IQ.

Identifying the genetic and environmental origins of cognitive and mental health problems in emerging adulthood and tracing their developmental roots is a fundamental step towards predicting and preventing these problems.

Technical Summary

This proposed 2015-20 extension of the Twins Early Development Study (TEDS) will apply its powerful design and dataset to 'emerging adulthood', a developmental era about which little is known even though it is a tipping point for life-long personal, social and societal problems.

For Objective 1, we will study 10,000 TEDS twins (5,000 pairs) after age 21 using online assessment, an approach pioneered by TEDS. We will estimate genetic and environmental sources of variance and covariance applying state-of-the-art quantitative genetic techniques, both the classic MZ-DZ twin design and a new quantitative genetic technique, Genome-wide Complex Trait Analysis (GCTA). GCTA and other genomic analyses, most notably genome-wide polygenic scores, will capitalise on genome-wide genotypes obtained in TEDS for 5,000 unrelated individuals and for 2,500 DZ co-twins, which provide within-family control. Comparisons between twin and GCTA analyses of variance are uniquely informative about the genetic architecture of complex traits and common disorders. Multivariate twin and GCTA analyses will test hypotheses about development, multivariate links between disorders and dimensions, and genotype-environment interaction and correlation and identify developmental, genetic and environmental predictors of outcomes at age 21.

For Objective 2, we will assess in person 600 TEDS twins with 70-79 IQ scores at age 21 (members of 400 twin pairs with at least one low-IQ proband), co-twins from discordant pairs, and 200 controls, focusing on their functional capabilities and adjustment. We will use DF extremes analysis to understand the extent to which functional impairment and adjustment of this group reflects genetic or environmental influences of low IQ. We aim to identify behavioural, genetic and environmental risk factors that predict differential functioning of this vulnerable group of emerging adults who are challenged cognitively.

Planned Impact

Who will benefit from this research? Because cognitive and mental health problems in emerging adulthood have far-reaching and long-lasting impact, the proposed research has a broad range of potential beneficiaries, including parents, clinicians, educators, policy-makers, and the wider public, in addition to academics.

How will they benefit from this research? Seven examples follow, with details including deliverables and metrics of success provided in Pathways to Impact.

Impact 1: Constructing polygenic scores to predict cognitive and mental health problems in emerging adulthood. An exciting prospect for predicting cognitive (e.g., literacy and numeracy) and mental health problems (e.g., anxiety/depression and drug use) in emerging adulthood is the aggregation of the associations of many genes in polygenic scores. These polygenic scores will enable more powerful research to develop personalised treatments, preventive interventions, improved diagnosis, and research on causal mechanisms. Co-Investigator, Dr Gerome Breen, who leads Genomics and Biomarkers for the IoPPN NIHR Biomedical Research Centre, will help us exploit the translational impact of our genomic research.

Impact 2: Improving the prediction of cognitive and mental health problems in emerging adulthood from behaviour and environment in earlier development. The TEDS resource of 20 years of behavioural and environmental assessments will make it possible to improve polygenic predictors of genetic risk by identifying behavioural and environmental risk and protective factors, controlling for genetic risk and considering moderators. Co-Investigator Professor Emily Simonoff, Head of the IoPPN Child and Adolescent Psychiatry Department, will help us exploit the impact of our research on clinicians and policymakers.

Impact 3: Identifying the adaptive functioning of low-IQ in emerging adulthood.
Intellectual disability is diagnosed on the basis of IQ <70 and low adaptive skills. We will investigate the adaptive skills of people with IQ 70-79 in order to identify the most meaningful criteria for services.

Impact 4: Documenting the societal costs of low IQ in emerging adulthood. New Co-Investigator, Professor Paul McCrone, Deputy Director of the IoPPN Centre for the Economics of Mental and Physical Health, will help us document the economic costs attributable to low IQ and to identify key drivers of these costs that may be modified through educational, health and social care interventions. This research could lead to changes in educational and health policy such as more targeted and cost-effective interventions.

Impact 5: Assessing attitudes towards the use of polygenic scores to predict cognitive and mental health problems. Consultant Dr Saskia Sanderson will help us investigate the views of TEDS twins and their parents on the use of personalised polygenic risk scores for cognitive and mental health problems. This will shed light on how to communicate the complexities of personalised polygenic scores, important first steps in translating genomic research into benefit, practice and policy.

Impact 6: TEDS as a resource. More than 100 collaborators are actively conducting research using the TEDS resource. We will continue to foster these collaborations in order to leverage the impact of the TEDS programme of research and as capacity-building for UK research.

Impact 7: TEDS as an opportunity for training. TEDS has helped to train a new generation of behavioural geneticists in the UK, with 12 former TEDS PhD students now in academic posts at UK universities. Capacity-building through training at both the PhD and postdoctoral level will continue to be a priority.

Organisations

Publications

10 25 50
 
Description Discussion with the Nuffield Council on Bioethics on genes and behaviour
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Workshop with members of HM Treasury
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description EU Marie Curie
Amount € 3,163,688 (EUR)
Funding ID 721567 CAPICE 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 02/2017 
End 01/2021
 
Title Web-based assessment of spatial visualisation abilities 
Description A series of tests of mental rotation and other spatial visualisation abilities, suitable for easy, remote administration via web browsers 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact (1) Paper published: "Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability", doi:10.1038/srep30545. (2) As well as permitting large-scale data collection in our own sample, the measure is available to other researchers, facilitating easy administration of a standardised test of this spatial skill. For example, this test is being used for cross-cultural comparisons with Russian and Chinese samples. 
 
Title Web-based battery of diverse spatial abilities 
Description Diverse tests across the breadth of the domain of spatial ability, all suitable for easy, remote administration via web browsers. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact (1) Paper published: "Phenotypic and genetic evidence for a unifactorial structure of spatial abilities", doi:10.1073/pnas.1607883114. (2) As well as permitting large-scale data collection in our own sample, the measure is available to other researchers, facilitating easy administration of a standardised test of this spatial skill. For example, these tests are being used for cross-cultural comparisons with Russian and Chinese samples. 
 
Title Web-based battery of navigational abilities. 
Description A 'gamified' test of diverse navigational skills in a 3D virtual environment, in a format suitable for easy, remote administration via web browsers. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2016 
Provided To Others? Yes  
Impact (1) A paper is in preparation. (2) As well as permitting large-scale data collection in our own sample, the measure is available to other researchers, facilitating easy administration of a standardised test of this spatial skill. For example, this battery is being used for cross-cultural comparisons with Russian and Chinese samples. 
 
Description A study of Genetics of Mathematical Cognition and Disabilities 
Organisation Goldsmiths, University of London
Department Department of Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-investigators on an NIH grant that was renewed in 2008 to conduct in-home testing of domain-general and maths-specific cognitive skills underpinning psychometric maths ability and disability for 500 TEDS families with children selected for domain-general (low maths + low reading) and maths-specific (low maths + normal reading) problems, which will provide interesting comparisons with the web-based data that we plan to collect as part of our MRC programme grant research at age 16.
Collaborator Contribution Collaborator is principal investigator on this grant.Analysis and assistance in writing papers based on the quantitative data.
Impact Although no publications have yet been forthcoming from the renewal funded in 2008, the previous grant was responsible for several collaborative publications: 'Scant evidence for Spearman's law of diminishing returns in middle childhood'; PMID18360741; PMID19634033; PMID19732386; PMID17983460; PMID19470122; 'The ABCs of math: A genetic analysis of mathematics and its links with reading ability and general cognitive ability'; 'A twin study into the genetic and environmental influences on academic performance in science in nine-year-old boys and girls'; PMID19377870; PMID19489895; PMID19496894; PMID17708696; 'Science in elementary school: Generalist genes and school environments'; PMID19573035; PMID17539370; 'Reading and generalist genes'; PMID19488046; PMID19381794; PMID16580870; 'Learning abilities and disabilities: Generalist genes, specialist environments'; PMID19238205; PMID19319204; PMID17995572; PMID17714376; PMID19756208; PMID17539369; PMID18355217; PMID19247827; PMID19220590; 'Genetics of learning abilities and disabilities: Recent developments from the UK and possible directions for research in China'; 'Generalist genes: Genetic links between brain, mind, and education'; 'The nature and nurture of intelligence and motivation in the origins of sex differences in elementary school achievement'; and 'Predicting school achievement from general cognitive ability, self-perceived ability, and intrinsic value'.
 
Description A study of Genetics of Mathematical Cognition and Disabilities 
Organisation Ohio State University
Country United States 
Sector Academic/University 
PI Contribution Co-investigators on an NIH grant that was renewed in 2008 to conduct in-home testing of domain-general and maths-specific cognitive skills underpinning psychometric maths ability and disability for 500 TEDS families with children selected for domain-general (low maths + low reading) and maths-specific (low maths + normal reading) problems, which will provide interesting comparisons with the web-based data that we plan to collect as part of our MRC programme grant research at age 16.
Collaborator Contribution Collaborator is principal investigator on this grant.Analysis and assistance in writing papers based on the quantitative data.
Impact Although no publications have yet been forthcoming from the renewal funded in 2008, the previous grant was responsible for several collaborative publications: 'Scant evidence for Spearman's law of diminishing returns in middle childhood'; PMID18360741; PMID19634033; PMID19732386; PMID17983460; PMID19470122; 'The ABCs of math: A genetic analysis of mathematics and its links with reading ability and general cognitive ability'; 'A twin study into the genetic and environmental influences on academic performance in science in nine-year-old boys and girls'; PMID19377870; PMID19489895; PMID19496894; PMID17708696; 'Science in elementary school: Generalist genes and school environments'; PMID19573035; PMID17539370; 'Reading and generalist genes'; PMID19488046; PMID19381794; PMID16580870; 'Learning abilities and disabilities: Generalist genes, specialist environments'; PMID19238205; PMID19319204; PMID17995572; PMID17714376; PMID19756208; PMID17539369; PMID18355217; PMID19247827; PMID19220590; 'Genetics of learning abilities and disabilities: Recent developments from the UK and possible directions for research in China'; 'Generalist genes: Genetic links between brain, mind, and education'; 'The nature and nurture of intelligence and motivation in the origins of sex differences in elementary school achievement'; and 'Predicting school achievement from general cognitive ability, self-perceived ability, and intrinsic value'.
 
Description ACTION 
Organisation Diagenode
Country Belgium 
Sector Private 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation Erasmus University Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation Free University of Amsterdam
Department VU Foundation
Country Netherlands 
Sector Charity/Non Profit 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation Good Biomarker Sciences
Country Netherlands 
Sector Private 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation Leiden University Medical Center
Country Netherlands 
Sector Multiple 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation University of Cagliari
Country Italy 
Sector Academic/University 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation University of Helsinki
Department Department of Virology
Country Finland 
Sector Academic/University 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation University of Notre Dame
Country United States 
Sector Academic/University 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description ACTION 
Organisation University of Queensland
Department Queensland Institute of Medical Research
Country Australia 
Sector Academic/University 
PI Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Collaborator Contribution ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.
Impact Ayorech, Z., Selzam, S., Smith-Woolley, E., Knopik, V. S., Neiderhiser, J. M., DeFries, J. C., & Plomin, R. (2016). Publication Trends Over 55 Years of Behavioral Genetic Research. Behavior Genetics, 46, 603-607. doi:10.1007/s10519-016-9786-2. PMC5206393. Ayorech, Z., von Stumm, S., Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2017). Personalized media: A genetically sensitive investigation of individual differences in online media use. PLoS ONE, 12, e0168895. doi:10.1371/journal.pone.0168895. . PMC5256859. Lewis, G. J., Asbury, K., & Plomin, R. (2016). Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons. Journal of Child Psychology and Psychiatry, 58, 292-304. doi:10.1111/jcpp.12655 Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E., van Beijsterveldt, C. E., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R., et al. (2016). Longitudinal heritability of childhood aggression. Am J Med Genet B Neuropsychiatr Genet, 171, 697-707. doi:10.1002/ajmg.b.32420 Selzam, S., Kraphol, E., von Stumm, S., O'Reilly, P., Rimfeld, K., Kovas, Y., Dale, P. S., Lee, J., & Plomin, R. (2016). Predicting Educational Achievement from DNA. Molecular Psychiatry, 22, 267-272. doi:10.1038/mp.2016.107. PMC5285461. Shakeshaft, N. G., Rimfeld, K., Schofield, K. L., Selzam, S., Malanchini, M., Rodic, M., Kovas, Y., & Plomin, R. (2016). Rotation is visualisation, 3D is 2D: using a novel measure to investigate the genetics of spatial ability. Scientific Reports, 6, 30545. doi:10.1038/srep30545. PMC4967849. Zabaneh, D., Krapohl, E., Simpson, M. A., Miller, M. B., Iacono, W. G., McGue, M., Putallaz, M., Lubinski, D., Plomin, R., et al. (2017). Fine mapping genetic associations between the HLA region and extremely high intelligence. Scientific Reports, 7, 41182. doi:10.1038/srep41182. PMC5259706.
Start Year 2014
 
Description CAPICE 
Organisation Erasmus University Rotterdam
Country Netherlands 
Sector Academic/University 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CAPICE 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CAPICE 
Organisation Johnson & Johnson
Department Janssen-Cilag
Country Global 
Sector Private 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CAPICE 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CAPICE 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CAPICE 
Organisation University of Catania
Country Italy 
Sector Academic/University 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CAPICE 
Organisation University of Gothenburg
Country Sweden 
Sector Academic/University 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CAPICE 
Organisation University of Twente
Country Netherlands 
Sector Academic/University 
PI Contribution In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with child and adolescent psychopathology. Professor Robert Plomin: supervising and training ESRs. He will take responsibility for network-wide training in statistical genetics, specifically twin studies.
Collaborator Contribution This collaboration will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses.
Impact Pending
Start Year 2017
 
Description CATSLife 
Organisation University of California
Country United States 
Sector Academic/University 
PI Contribution Will assist with the many CATSLife analyses that emerge from the extension of CAP and LTS into early adulthood. However, the primary focus of the analyses will be to replicate CATSLife results using the TEDS longitudinal dataset on 7500 pairs of twins, which includes many of the mediators and moderators assessed in CAP and LTS in emerging adulthood, although not to the upper end of the age-span in CATSLife and without as much data on physical health as in CATSLife. Attempts will also be made to conduct combined adoption/twin analyses of CATSLife, LTS and TEDS when possible. Finally, TEDS has genome wide genotype data for nearly 6000 unrelated TEDS participants, which will enable SNP-based genetic analyses of variance and covariance and polygenic score analyses  between DNA markers and measures, mediators and moderators relevant to the proposed CATSLife project. 
Collaborator Contribution The resulting Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife) will be the first prospective longitudinal study of the etiologies of behavioral and cognitive changes during the transition to middle adulthood. The aims are to: conduct a genetically sensitive study of individual differences in behavioral and cognitive change at the cusp of middle adulthood, in 1600 participants studied almost yearly from birth to early adulthood; map individual differences in growth and maintenance of cognitive abilities; evaluate and trace measured physical factors and health behaviors, biochemical markers and measured genetic pathways important to sustaining cognitive performance; and track measured environmental factors that may decrease, sustain or boost cognitive performance. The CATSLife will include expanded assessment of cognitive performance, physical functioning and health behaviors, gene pathways, including measured genetic variation in lipid, synaptic plasticity and cell-signaling paths (based on chip array variants), biochemical markers (e.g., serum lipids), and environmental measures (e.g., engagement in leisure activities). We will assess etiologies of changes in physical health and cognitive functioning, and test whether associations across domains change with age due to changes in genetic variation or self-selection of environments. Measured gene pathway sets, and environmental measures, including engagement in leisure activities and neighborhood-level variables, will be evaluated as potential factors underlying dynamics of genetic variation or environmental selection. Thus, the CATSLife will provide an unparalleled opportunity to assess prospectively the etiologies of cognitive change, and test the saliency of early childhood versus proximal influences on the genesis of cognitive decline.
Impact PMC4967849
Start Year 2015
 
Description CATSLife 
Organisation University of Colorado
Country United States 
Sector Academic/University 
PI Contribution Will assist with the many CATSLife analyses that emerge from the extension of CAP and LTS into early adulthood. However, the primary focus of the analyses will be to replicate CATSLife results using the TEDS longitudinal dataset on 7500 pairs of twins, which includes many of the mediators and moderators assessed in CAP and LTS in emerging adulthood, although not to the upper end of the age-span in CATSLife and without as much data on physical health as in CATSLife. Attempts will also be made to conduct combined adoption/twin analyses of CATSLife, LTS and TEDS when possible. Finally, TEDS has genome wide genotype data for nearly 6000 unrelated TEDS participants, which will enable SNP-based genetic analyses of variance and covariance and polygenic score analyses  between DNA markers and measures, mediators and moderators relevant to the proposed CATSLife project. 
Collaborator Contribution The resulting Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife) will be the first prospective longitudinal study of the etiologies of behavioral and cognitive changes during the transition to middle adulthood. The aims are to: conduct a genetically sensitive study of individual differences in behavioral and cognitive change at the cusp of middle adulthood, in 1600 participants studied almost yearly from birth to early adulthood; map individual differences in growth and maintenance of cognitive abilities; evaluate and trace measured physical factors and health behaviors, biochemical markers and measured genetic pathways important to sustaining cognitive performance; and track measured environmental factors that may decrease, sustain or boost cognitive performance. The CATSLife will include expanded assessment of cognitive performance, physical functioning and health behaviors, gene pathways, including measured genetic variation in lipid, synaptic plasticity and cell-signaling paths (based on chip array variants), biochemical markers (e.g., serum lipids), and environmental measures (e.g., engagement in leisure activities). We will assess etiologies of changes in physical health and cognitive functioning, and test whether associations across domains change with age due to changes in genetic variation or self-selection of environments. Measured gene pathway sets, and environmental measures, including engagement in leisure activities and neighborhood-level variables, will be evaluated as potential factors underlying dynamics of genetic variation or environmental selection. Thus, the CATSLife will provide an unparalleled opportunity to assess prospectively the etiologies of cognitive change, and test the saliency of early childhood versus proximal influences on the genesis of cognitive decline.
Impact PMC4967849
Start Year 2015
 
Description Consortium on the Genetics of High Cognitive Abilities (GHCA) 
Organisation Ohio State University
Country United States 
Sector Academic/University 
PI Contribution Cognitive ability data obtained from TEDS will be used in this study.
Collaborator Contribution Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive ability abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a member of the GHCA consortium and is an expert on the genetics of cognitive ability. Collaborator has obtained cognitive ability data that the study will be based upon.Collaborator is a GHCA consortium member and provides expertise on high cognitive abilities.Collaborator is a GHCA member and provides expertise on the genetics of cognitive abilties. Collaborator has obtained cognitive ability data to be used in the study.
Impact The following publications have arisen from this study so far: PMID19488046; PMID19381794; PMID19247827; PMID: 19430899; PMID: 19424784; PMID: 19288254; PMID: 19377873; PMID: 19377874; PMID: 19418212; PMID: 19296213; PMID: 19377870.
Start Year 2008
 
Description Consortium on the Genetics of High Cognitive Abilities (GHCA) 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Cognitive ability data obtained from TEDS will be used in this study.
Collaborator Contribution Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive ability abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a member of the GHCA consortium and is an expert on the genetics of cognitive ability. Collaborator has obtained cognitive ability data that the study will be based upon.Collaborator is a GHCA consortium member and provides expertise on high cognitive abilities.Collaborator is a GHCA member and provides expertise on the genetics of cognitive abilties. Collaborator has obtained cognitive ability data to be used in the study.
Impact The following publications have arisen from this study so far: PMID19488046; PMID19381794; PMID19247827; PMID: 19430899; PMID: 19424784; PMID: 19288254; PMID: 19377873; PMID: 19377874; PMID: 19418212; PMID: 19296213; PMID: 19377870.
Start Year 2008
 
Description Consortium on the Genetics of High Cognitive Abilities (GHCA) 
Organisation University of Colorado Boulder
Country United States 
Sector Academic/University 
PI Contribution Cognitive ability data obtained from TEDS will be used in this study.
Collaborator Contribution Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive ability abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a member of the GHCA consortium and is an expert on the genetics of cognitive ability. Collaborator has obtained cognitive ability data that the study will be based upon.Collaborator is a GHCA consortium member and provides expertise on high cognitive abilities.Collaborator is a GHCA member and provides expertise on the genetics of cognitive abilties. Collaborator has obtained cognitive ability data to be used in the study.
Impact The following publications have arisen from this study so far: PMID19488046; PMID19381794; PMID19247827; PMID: 19430899; PMID: 19424784; PMID: 19288254; PMID: 19377873; PMID: 19377874; PMID: 19418212; PMID: 19296213; PMID: 19377870.
Start Year 2008
 
Description Consortium on the Genetics of High Cognitive Abilities (GHCA) 
Organisation University of Minnesota
Country United States 
Sector Academic/University 
PI Contribution Cognitive ability data obtained from TEDS will be used in this study.
Collaborator Contribution Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive ability abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a member of the GHCA consortium and is an expert on the genetics of cognitive ability. Collaborator has obtained cognitive ability data that the study will be based upon.Collaborator is a GHCA consortium member and provides expertise on high cognitive abilities.Collaborator is a GHCA member and provides expertise on the genetics of cognitive abilties. Collaborator has obtained cognitive ability data to be used in the study.
Impact The following publications have arisen from this study so far: PMID19488046; PMID19381794; PMID19247827; PMID: 19430899; PMID: 19424784; PMID: 19288254; PMID: 19377873; PMID: 19377874; PMID: 19418212; PMID: 19296213; PMID: 19377870.
Start Year 2008
 
Description Consortium on the Genetics of High Cognitive Abilities (GHCA) 
Organisation University of Queensland
Department School of Psychology
Country Australia 
Sector Academic/University 
PI Contribution Cognitive ability data obtained from TEDS will be used in this study.
Collaborator Contribution Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive ability abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a member of the GHCA consortium and is an expert on the genetics of cognitive ability. Collaborator has obtained cognitive ability data that the study will be based upon.Collaborator is a GHCA consortium member and provides expertise on high cognitive abilities.Collaborator is a GHCA member and provides expertise on the genetics of cognitive abilties. Collaborator has obtained cognitive ability data to be used in the study.
Impact The following publications have arisen from this study so far: PMID19488046; PMID19381794; PMID19247827; PMID: 19430899; PMID: 19424784; PMID: 19288254; PMID: 19377873; PMID: 19377874; PMID: 19418212; PMID: 19296213; PMID: 19377870.
Start Year 2008
 
Description Consortium on the Genetics of High Cognitive Abilities (GHCA) 
Organisation Vanderbilt University
Country United States 
Sector Academic/University 
PI Contribution Cognitive ability data obtained from TEDS will be used in this study.
Collaborator Contribution Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a GHCA member and is an expert on the genetics of cognitive ability abilitites and has obtained cognitive ability data that will be used in the study.Collaborator is a member of the GHCA consortium and is an expert on the genetics of cognitive ability. Collaborator has obtained cognitive ability data that the study will be based upon.Collaborator is a GHCA consortium member and provides expertise on high cognitive abilities.Collaborator is a GHCA member and provides expertise on the genetics of cognitive abilties. Collaborator has obtained cognitive ability data to be used in the study.
Impact The following publications have arisen from this study so far: PMID19488046; PMID19381794; PMID19247827; PMID: 19430899; PMID: 19424784; PMID: 19288254; PMID: 19377873; PMID: 19377874; PMID: 19418212; PMID: 19296213; PMID: 19377870.
Start Year 2008
 
Description MQ Fellowship award to Jean-Baptiste Pingault - Bullying and mental health: a genetically informative approach 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution MQ Grant - I will use statistical innovation and genetically informative designs to achieve the following three novel aims: -To probe the causal nature of the associations between childhood bullying victimisation and the development of a range of relevant mental health problems into early adulthood -To examine the unique effects of cyber-bullying victimisation on concurrent mental health problems in early adulthood. -To identify specific risk factors for bullying victimisation and cyber-bullying victimisation To this end, my team and I will use three large population-based cohorts with comprehensive data on victimisation, outcomes, risk factors and relevant genetic data. This project represents the most comprehensive research programme to date on bullying victimisation and mental health and could change radically our causal understanding of bullying victimisation and prevention strategies
Collaborator Contribution MQ Grant - I will use statistical innovation and genetically informative designs to achieve the following three novel aims: -To probe the causal nature of the associations between childhood bullying victimisation and the development of a range of relevant mental health problems into early adulthood -To examine the unique effects of cyber-bullying victimisation on concurrent mental health problems in early adulthood. -To identify specific risk factors for bullying victimisation and cyber-bullying victimisation To this end, my team and I will use three large population-based cohorts with comprehensive data on victimisation, outcomes, risk factors and relevant genetic data. This project represents the most comprehensive research programme to date on bullying victimisation and mental health and could change radically our causal understanding of bullying victimisation and prevention strategies
Impact Singham, T., Viding, E., Schoeler, T., Arseneault, L., Ronald, A., Cecil, C. M., ... & Pingault, J. B. (2017). Concurrent and longitudinal contribution of exposure to bullying in childhood to mental health: the role of vulnerability and resilience. JAMA psychiatry, 74(11), 1112-1119.
Start Year 2017
 
Description MQ Fellowship award to Jean-Baptiste Pingault - Bullying and mental health: a genetically informative approach 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution MQ Grant - I will use statistical innovation and genetically informative designs to achieve the following three novel aims: -To probe the causal nature of the associations between childhood bullying victimisation and the development of a range of relevant mental health problems into early adulthood -To examine the unique effects of cyber-bullying victimisation on concurrent mental health problems in early adulthood. -To identify specific risk factors for bullying victimisation and cyber-bullying victimisation To this end, my team and I will use three large population-based cohorts with comprehensive data on victimisation, outcomes, risk factors and relevant genetic data. This project represents the most comprehensive research programme to date on bullying victimisation and mental health and could change radically our causal understanding of bullying victimisation and prevention strategies
Collaborator Contribution MQ Grant - I will use statistical innovation and genetically informative designs to achieve the following three novel aims: -To probe the causal nature of the associations between childhood bullying victimisation and the development of a range of relevant mental health problems into early adulthood -To examine the unique effects of cyber-bullying victimisation on concurrent mental health problems in early adulthood. -To identify specific risk factors for bullying victimisation and cyber-bullying victimisation To this end, my team and I will use three large population-based cohorts with comprehensive data on victimisation, outcomes, risk factors and relevant genetic data. This project represents the most comprehensive research programme to date on bullying victimisation and mental health and could change radically our causal understanding of bullying victimisation and prevention strategies
Impact Singham, T., Viding, E., Schoeler, T., Arseneault, L., Ronald, A., Cecil, C. M., ... & Pingault, J. B. (2017). Concurrent and longitudinal contribution of exposure to bullying in childhood to mental health: the role of vulnerability and resilience. JAMA psychiatry, 74(11), 1112-1119.
Start Year 2017
 
Description MQ Fellowship award to Jean-Baptiste Pingault - Bullying and mental health: a genetically informative approach 
Organisation University College London
Department Department of Psychology and Human Development
Country United Kingdom 
Sector Academic/University 
PI Contribution MQ Grant - I will use statistical innovation and genetically informative designs to achieve the following three novel aims: -To probe the causal nature of the associations between childhood bullying victimisation and the development of a range of relevant mental health problems into early adulthood -To examine the unique effects of cyber-bullying victimisation on concurrent mental health problems in early adulthood. -To identify specific risk factors for bullying victimisation and cyber-bullying victimisation To this end, my team and I will use three large population-based cohorts with comprehensive data on victimisation, outcomes, risk factors and relevant genetic data. This project represents the most comprehensive research programme to date on bullying victimisation and mental health and could change radically our causal understanding of bullying victimisation and prevention strategies
Collaborator Contribution MQ Grant - I will use statistical innovation and genetically informative designs to achieve the following three novel aims: -To probe the causal nature of the associations between childhood bullying victimisation and the development of a range of relevant mental health problems into early adulthood -To examine the unique effects of cyber-bullying victimisation on concurrent mental health problems in early adulthood. -To identify specific risk factors for bullying victimisation and cyber-bullying victimisation To this end, my team and I will use three large population-based cohorts with comprehensive data on victimisation, outcomes, risk factors and relevant genetic data. This project represents the most comprehensive research programme to date on bullying victimisation and mental health and could change radically our causal understanding of bullying victimisation and prevention strategies
Impact Singham, T., Viding, E., Schoeler, T., Arseneault, L., Ronald, A., Cecil, C. M., ... & Pingault, J. B. (2017). Concurrent and longitudinal contribution of exposure to bullying in childhood to mental health: the role of vulnerability and resilience. JAMA psychiatry, 74(11), 1112-1119.
Start Year 2017
 
Title Twins Early Development mobile phone application 
Description A mobile phone application allowing study participants to fill in their research questionnaires on their phone 
Type Of Technology Webtool/Application 
Year Produced 2017 
Impact The majority of the study participants now fill out their questionnaires using the app. 
 
Description 2015 40-minute audio interview with the UK Guardian newspaper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact July 2015: 40-minute audio interview with Robert for the UK Guardian newspaper: http://www.theguardian.com/science/audio/2015/jul/17/genetic-screen-science-podcast
Year(s) Of Engagement Activity 2015
URL http://www.theguardian.com/science/audio/2015/jul/17/genetic-screen-science-podcast
 
Description 2015 Coverage of Shakeshaft et al paper in PNAS 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact News coverage of Genetic specificity of face recognition paper
Year(s) Of Engagement Activity 2015
URL https://www.newscientist.com/article/dn28258-our-knack-for-remembering-faces-is-a-highly-evolved-ski...
 
Description 2015 Half-hour film about Robert Plomin's Twins Early Development Study (TEDS) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact In May 2015 a half-hour film about Robert Plomin's Twins Early Development Study (TEDS) was produced to mark 20 years of the study: https://www.youtube.com/watch?v=-LaGbuQnBnQ
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=-LaGbuQnBnQ
 
Description 2015 Half-hour interview BBC Radio 4's distinguished program, The Life Scientific 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact October 2015: Half-hour interview with Robert Plomin on BBC Radio 4's distinguished program, The Life Scientific: (http://www.bbc.co.uk/programmes/b06j1qts)
Year(s) Of Engagement Activity 2015
URL http://www.bbc.co.uk/programmes/b06j1qts
 
Description 2015 Headline speaker for the Times Festival of Education: 'Is Intelligence Heritable?' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Headline speaker for the Times Festival of Education: 'Is Intelligence Heritable' 17 June 2015 (Welliington College)
And 'Genetics and Education' 18 June 2015.
Year(s) Of Engagement Activity 2015
 
Description 2015 ISIR - Invited talk (Albuquerque, New Mexico) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Professor Plomin gave a talk to a predominantly academic audience. The title of his talk was 'A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence'
Year(s) Of Engagement Activity 2015
 
Description 2015 ISIR - distinquished contributor interview (Albuquerque, New Mexico) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact November 2015: Hour-long filmed interview with Robert Plomin as part of his lifetime achievement award from the International Society of Intelligence Research: https://www.youtube.com/watch?v=wiDWj_idj8w
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=wiDWj_idj8w
 
Description 2015 Interview with Robert Plomin in Die Zeit 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact June 2015: Interview with Robert Plomin in Die Zeit: http://www.zeit.de/2015/23/intelligenz-vererbung-iq-robert-plomin
Year(s) Of Engagement Activity 2015
URL http://www.zeit.de/2015/23/intelligenz-vererbung-iq-robert-plomin
 
Description 2015 Interviews RE von Stumm paper in PLOSone 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press coverage of paper 'Breastfeeding and IQ Growth from Toddlerhood through Adolescence'.
Coverage in:
http://www.dailymail.co.uk/health/article-3246372/Breast-NOT-best-comes-IQ-Children-breastfed-no-intelligent-bottle-fed.html
http://www.express.co.uk/news/science/607477/breast-fed-babies-no-more-clever-than-bottle-fed-research-intelligence
https://www.google.com/url?rct=j&sa=t&url=http://www.scotsman.com/news/health/breastfed-babies-not-more-intelligent-say-experts-1-3896403&ct=ga&cd=CAEYACoUMTgwODAxMzA2OTc3Nzg2NjQwODYyHjdmMWNmYTUzMTM2YzBjZWU6Y28udWs6ZW46R0I6TA&usg=AFQjCNHDlVu_rpc6NmuGWJ26dGnjs1RKAQ
http://www.telegraph.co.uk/news/health/news/11886646/Breastfeeding-does-not-improve-IQ-study-finds.html
http://www.westerndailypress.co.uk/8203-Breast-feeding-benefit-bottle-feeding-comes/story-27852880-detail/story.html
http://www.huffingtonpost.co.uk/2015/09/24/breastfeeding-iq-study-intelligence-bottle-feeding_n_8187692.html
http://www.techtimes.com/articles/87967/20150924/breast-feeding-no-different-from-bottle-feeding-for-improving-baby-iq.htm
Year(s) Of Engagement Activity 2015
 
Description 2015 Numerous presentations at ICPS (Amsterdam, Netherlands) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact International Convention of Psychological Science (ICPS), 12-14th March 2015, Amsterdam, Netherlands
Presentation title: Why is educational achievement so highly heritable? (part of the symposium: Genetically informative investigations into child development).
PhD student Kaili Rimfeld presented recent findings from educational achievement using both, the classical twin study that compares identical and non-identical twins and a new method based on a DNA alone (GCTA).
Presentation title: How general is general cognition? Evidence from specific domains
PhD student Nicholas Shakeshaft presented findings focused on general cognitive ability. Specific cognitive abilities, from mathematical ability to literacy, have typically been found to be highly heritable, and substantially correlated with general cognitive ability ('g').
Presentation title: Genetic link between family socioeconomic status and children's educational achievement estimated from genome-wide SNPs
PhD student Eva Krapohl presented findings on the best predictors of children's educational achievement.
Presentation title: The role of polygenic scores in the prediction of the developmental course of behavioural problems from early childhood to adolescence
PhD student Eva Krapohl explained how latent growth curves were used to model the overall behaviour problems score.
Year(s) Of Engagement Activity 2015
 
Description 2015 Social Genetic and Developmental Psychiatry Centre talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presented at the Social Genetic and Developmental Psychiatry Centre weekly seminars
Year(s) Of Engagement Activity 2015
 
Description 2015 Twins Early Development Study Infographic 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Infographic sent to study participants
Year(s) Of Engagement Activity 2015
 
Description 2015 Twins Early Development Study Interview with Naked Scientists re Shakeshaft et al paper 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interview with memver of the Twins Early Development Study team regarding paper: Genetic specificity of face recognition:
http://www.bbc.co.uk/programmes/p032vbxw
http://www.thenakedscientists.com/HTML/typo3conf/ext/naksci_podcast/jplayer/player.php?podcast=1001174?em=1004185
Year(s) Of Engagement Activity 2015
 
Description 2015 Twins Early Development Study newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact The annual TEDS newsletter which goes out to all participants
Year(s) Of Engagement Activity 2015
 
Description 2015 Undergraduate seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Undergraduate seminar to 150 psychology students
Year(s) Of Engagement Activity 2015
 
Description 2015 online video and audio interviews featuring Robert Plomin 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact November 2015: Interview with Robert Plomin in Times Education Supplement
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=-4VCISnwE-k
 
Description 2015 presentation at BGA, San Diego, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Behavioral Genetics Association (BGA) meeting. 17-20 of June. San Diego, USA
Presenter - PhD student Kaili Rimfeld
Presentation title: Genetic and environmental underpinnings of spatial abilities and their role in predicting academic achievement and success in STEM
Presenter - PhD student Eva Krapohl
Presentation title: Phenome-wide analysis of genome-wide polygenic scores
Year(s) Of Engagement Activity 2015
 
Description 2015 presentation at Estonian Genome Centre, Tartu, Estonia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Presentation title: Quantitative Genetic research into cognitive development and educational achievement using the Twin Early Development Study (TEDS) sample.
PhD student Kaili Rimfeld gave a talk that introduced the Twins Early Development Study and discussed the main findings in recent years focusing on the cognitive and educational achievement outcomes using behavioral genetic methods.
The second part of the talk focused on the top 10 replicated findings from behavioral genetics (Plomin, R., DeFries, J. C., Knopik, V. S., & Neiderhiser, J. M. (2016). Top 10 Replicated Findings From Behavioral Genetics. Perspectives on Psychological Science, 11(1), 3-23.)
Year(s) Of Engagement Activity 2015
 
Description 2015 talk at the ISIR conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Nicholas Shakeshaft, a TEDS PhD student gave the talk "The genetic specificity of face perception" at the International Society for Intelligence Research conference
Year(s) Of Engagement Activity 2015
 
Description 2016 Coverage of Rimfeld et al paper in Scientific Reports 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release and news coverage of Rimfeld et al study on A levels, published in Scientific Reports:
Daily Mail - http://www.dailymail.co.uk/sciencetech/article-3644754/A-level-choice-DNA-Decision-pursue-qualifications-influenced-genes.html
Estonian National TV: http://novaator.err.ee/v/haridus/c50efbbe-0e32-41e3-98a7-8de5f7fd831b/uldhariduses-voiks-opiraskuste-ennetamiseks-kasutada-lapse-vaimset-voimekust-mootvat-geenitesti
The Guardian: https://www.theguardian.com/science/2016/jun/16/a-level-subject-choice-is-strongly-influenced-by-genes-scientists-say
Year(s) Of Engagement Activity 2016
URL http://www.dailymail.co.uk/sciencetech/article-3644754/A-level-choice-DNA-Decision-pursue-qualificat...
 
Description 2016 Interview with Robert Plomin for the tes 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Interview with Dr Kat Arney for the tes
Year(s) Of Engagement Activity 2016
URL https://www.tes.com/news/tes-magazine/tes-magazine/unleashing-power-potential
 
Description 2016 talk with postgraduate students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Presentation to postgraduate students
Year(s) Of Engagement Activity 2016
 
Description A talk or presentation - Talk about about polygenic scores by PhD student 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Emily Smith-Woolley (PhD student) gave a lecture at Goldsmiths, University of London on the creation and use of polygenic scores
Year(s) Of Engagement Activity 2017
 
Description APA lifetime achievement award talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave an award speech for the APA Lifetime achievement award in the US
Year(s) Of Engagement Activity 2017
URL https://www.kcl.ac.uk/ioppn/news/records/2017/September/Prof-Plomin-'without-peer-in-history-of-Amer...
 
Description Article in Psychology Today 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article in Psychology Today on Self Confidence
Year(s) Of Engagement Activity 2016
URL https://www.psychologytoday.com/blog/wired-success/201702/is-self-confidence-inherited-renewed-debat...
 
Description Article in the Financial Times: The genetic advantage of the (other) 1 percenters 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview for the Financial Times on the 'Genetic Advantage of the 1 percenters'
Year(s) Of Engagement Activity 2016
URL https://www.ft.com/content/b445e250-79d5-11e6-97ae-647294649b28
 
Description Born Clever of Made 0 interview for the Naked Scientists 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interview for the Naked Scientists on 'Born clever or made?'
Year(s) Of Engagement Activity 2016
URL https://www.thenakedscientists.com/articles/interviews/born-clever-or-made
 
Description Filmed interviews with the research team about their research 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Video interviews of the research team talking about their research. These videos were published on the King's College Youtube channel and included in press releases to the media. For example: https://www.youtube.com/watch?v=kT7WfQGgmP4&t=32s & https://www.youtube.com/watch?v=ZTrbsjAvRaA&t=50s & https://www.youtube.com/watch?v=2sdRNpqcB6Y&t=49s
Year(s) Of Engagement Activity 2017
URL https://www.youtube.com/watch?v=ZTrbsjAvRaA&t=50s
 
Description Genetics and Education podcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Genetics and education podcast for the BBC
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/b079m0sb
 
Description Hosted and spoke at a workshop with members of the UK Treasury 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Hosted and spoke at a workshop with members of the UK Treasury to present findings from recent research on genetics and education
Year(s) Of Engagement Activity 2017
 
Description Interview for the tes 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Interviewed for the tes about genetics and education
Year(s) Of Engagement Activity 2015
URL https://www.tes.com/news/school-news/breaking-news/exclusive-tes-film-dont-be-afraid-genetics-leadin...
 
Description Interviews re Rimfeld et al Scientific Reports 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interviews, press releases and commentary on paper: 'Pleiotropy across academic subjects at the end of compulsory education'
Coverage:
http://www.dailymail.co.uk/sciencetech/article-3172385/GCSE-results-GENES-DNA-plays-bigger-exam-success-school-home-life-combined.html
http://www.telegraph.co.uk/education/educationnews/11758761/Failed-your-GCSEs-You-should-blame-your-genes.html
http://www.theguardian.com/science/2015/jul/23/genes-influence-academic-ability-across-all-subjects-latest-study-shows
https://theconversation.com/the-same-genes-influence-exam-results-across-a-range-of-school-subjects-45059
http://www.mirror.co.uk/news/technology-science/science/how-well-you-your-gcses-6126756
Year(s) Of Engagement Activity 2015
URL http://www.dailymail.co.uk/sciencetech/article-3172385/GCSE-results-GENES-DNA-plays-bigger-exam-succ...
 
Description Keynote address, British Society of Personality and Individual Differences, Canterbury UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote address, British Society of Personality and Individual Differences, Canterbury UK
Year(s) Of Engagement Activity 2017
 
Description Media activity around research paper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Media interest around the research paper 'Personalized Media: A Genetically Informative Investigation of Individual Differences in Online Media Use' by Ayorech....Plomin (2017) https://www.ft.com/content/419733b2-e181-11e6-9645-c9357a75844a https://www.thesun.co.uk/living/2686719/your-facebook-addiction-is-written-in-your-dna-your-genes-influence-how-long-you-spend-online/ http://m.classfmonline.com/1.10697714
Year(s) Of Engagement Activity 2017
URL https://www.ft.com/content/419733b2-e181-11e6-9645-c9357a75844a
 
Description Media activity around research paper 'Genetic Influence on Intergenerational Educational Attainment ' 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Blog on the research paper 'Genetic Influence on Intergenerational Educational Attainment'
Year(s) Of Engagement Activity 2017
URL https://theconversation.com/social-mobility-is-in-your-genes-finds-new-study-81291
 
Description Media coverage for Ayorech et al 2016 in PLoS one 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Media attention for a paper on the heritability of media use:
http://www.bbc.co.uk/programmes/b08b7vyd#play
https://www.ft.com/content/419733b2-e181-11e6-9645-c9357a75844a
http://www.dailymail.co.uk/health/article-4149404/Are-addicted-Facebook-genes.html
https://www.thesun.co.uk/living/2686719/your-facebook-addiction-is-written-in-your-dna-your-genes-influence-how-long-you-spend-online/
http://www.thetimes.co.uk/edition/news/one-in-three-children-checks-their-phone-every-few-minutes-rftz60knv
http://news.xinhuanet.com/english/2017-01/24/c_136007532.htm (Xinhua - China)
http://www.newindianexpress.com/lifestyle/health/2017/jan/24/facebook-addiction-actually-lies-in-your-genes-1563002.html
http://www.lasicilia.it/news/salute/57577/ricerca-passione-per-social-chat-blog-e-siti-online-e-scritta-nei-geni.html
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08b7vyd#play
 
Description Ongoing social media 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Ongoing social media. Regularly updated Facebook and Twitter accounts:
https://www.facebook.com/TedsProject
https://twitter.com/tedsproject
Year(s) Of Engagement Activity 2014,2015
URL https://twitter.com/tedsproject
 
Description Ongoing social media 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Ongoing social media for the Twins Early Development Study:
facebook: https://www.facebook.com/TedsProject/
Twitter: https://twitter.com/TedsProject?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor
Year(s) Of Engagement Activity 2016,2017
URL https://twitter.com/TedsProject?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor
 
Description Press release and media attention around Selzam et al 2016 paper in Molecular Psychiatry 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Media attention for the paper by Selzam et al 2016 in Molecular Psychiatry:
Huffington Post: http://www.huffingtonpost.co.uk/entry/a-simple-dna-test-could-predict-how-well-your-child-will-do-at-school_uk_578f584de4b046a0b6143f5d
Metro: http://metro.co.uk/2016/07/19/new-dna-test-can-tell-if-your-child-is-clever-or-doomed-to-fail-6016216/
Financial Times: https://next.ft.com/content/e4f90a28-4cf1-11e6-88c5-db83e98a590a
Daily Mail: http://www.dailymail.co.uk/sciencetech/article-3697029/Can-DNA-reveal-exams-Scientists-pinpoint-genes-used-predict-academic-achievement.html
Daily Mirror: http://www.mirror.co.uk/news/world-news/want-know-how-your-child-8446391
press Association: http://home.bt.com/news/science-news/academically-bright-your-genetics-may-have-something-to-do-with-it-scientists-say-11364074365113
Times Education Supplement: https://www.tes.com/news/school-news/breaking-news/intelligence-its-your-dna-study-says
Year(s) Of Engagement Activity 2016
URL https://next.ft.com/content/e4f90a28-4cf1-11e6-88c5-db83e98a590a
 
Description Public lecture; Cambridge Society for the Application of Research, Cambridge UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave a talk at Cambridge Society for the Application of Research titled 'The DNA Revolution Has Arrived in the Behavioural Sciences'
Year(s) Of Engagement Activity 2017
URL https://www.csar.org.uk/lectures/2017-2018/the-dna-revolution-has-arrived-in-the-behavioural-science...
 
Description Radio interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Radio interview with CBC Radio
Year(s) Of Engagement Activity 2017
URL http://www.cbc.ca/radio/quirks/trump-exits-paris-accord-finding-genes-linked-to-intelligence-and-mor...
 
Description Research team members gave a presentation at the Behavioral Genetics Association conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Four research team members gave presentations at the Behavioral Genetics Association conference in Oslo
Year(s) Of Engagement Activity 2017
 
Description Research team members gave a presentation at the British Society for the Psychology of Individual Differences conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Two members of the research team gave presentations at the British Society for the Psychology of Individual Differences conference in Kent
Year(s) Of Engagement Activity 2017
 
Description SGDP Centre open day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Principal investigator and members of the research team participated in the MRC Social, Genetic, and Developmental Psychiatry Centre Open Day . This involved engaging members of the local community, local schoolchildren, and those with a specific interest in the work of the Centre. Activities were designed to explain the use of the twin study model within the Twins Early Development Study and to provide young schoolchildren with a basic understanding of twins as a concept.
Year(s) Of Engagement Activity 2017
 
Description Serious Science talk 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Talk for 'Serious science' looking at how genes and environment affect our development and intelligence
Year(s) Of Engagement Activity 2016
URL http://serious-science.org/behavioral-genetics-7975
 
Description Speaking at Pint of Science festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Professor Plomin gave a 30 min talk to the general public (including students) for Pint of Science Festival 2016
Year(s) Of Engagement Activity 2016
 
Description TEDS Talks on TEDS papers 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact A series of talks for TEDS Youtube channel:
https://www.youtube.com/watch?v=2sdRNpqcB6Y&t=45s
https://www.youtube.com/watch?v=9vq9WEIx0PI&t=25s
https://www.youtube.com/watch?v=_l1U0ftM1rI&t=17s
Year(s) Of Engagement Activity 2016,2017
URL https://www.youtube.com/watch?v=9vq9WEIx0PI&t=25s
 
Description TEDS talks series 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Series of video interviews with TEDS researchers about their work:
https://www.youtube.com/watch?v=usP3KFsDloA
https://www.youtube.com/watch?v=fteDvLsfEL0
https://www.youtube.com/watch?v=RPVeU8zqev8
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=usP3KFsDloA
 
Description Talk about about behavioural genetics by post-doctoral student 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Kaili Rimfled (Post-doctoral student) gave a lecture at Goldsmiths, University of London
Year(s) Of Engagement Activity 2017
 
Description Talk about twin studies by PhD student 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A talk on Twin studies by one of Professor Plomin's PhD students Emily Smith-Woolley
http://www.localbuzzmagazine.com/2016/08/25/identically-different-what-twin-research-reveals-about-who-we-are/
http://kennetradio.com/site/things-to-do/newbury-talks-identically-different/
http://newburyobserver.co.uk/talk-on-twins-coming-to-the-corn-exchange
Year(s) Of Engagement Activity 2016
URL http://www.localbuzzmagazine.com/2016/08/25/identically-different-what-twin-research-reveals-about-w...
 
Description Talk at Better Data event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Talk at the 'Better Data' conference
Year(s) Of Engagement Activity 2016
URL http://better-data.co.uk/video-gallery/
 
Description Talk at the 'Aggression in Children: unraveling gene-environment interplay to inform treatment and intervention strategies' (ACTION) workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact Spoke at the workshop for ACTION research in Amsterdam
Year(s) Of Engagement Activity 2017
URL http://www.action-euproject.eu/Project
 
Description Talk at the Social Genetic and Developmental Psychiatry centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A talk on predicting educational achievement from polygenic scores held at the Social, Genetic and Developmental Psychiatry Centre
Year(s) Of Engagement Activity 2017
 
Description Today Programme - PhD student talking about thier research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact PhD student Ziada Ayorech speaks about her research on Radio 4 Today programme
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08b7vyd
 
Description Twins Early Development annual newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact The Twins Early Development Annual Newsletter which goes out to all study participants and relevant researchers working on the project. This is a round up of the year with research stories, news and updates.
Year(s) Of Engagement Activity 2017
 
Description Various undergraduate lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact The principle investigator has given a number of undergraduate lectures at King's College London, London School of Economics and Goldsmiths, University of London
Year(s) Of Engagement Activity 2017
 
Description Video Interview for EDGE on 'Why we are different' 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A video interview with EDGE magazine about 'Why we are different'
Year(s) Of Engagement Activity 2016
URL https://www.edge.org/conversation/robert_plomin-why-were-different
 
Description Work experience students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact The research team have hosted a number of work placement students from local schools who come to TEDS to learn about the study and about working with large data sets
Year(s) Of Engagement Activity 2017
 
Description World Association for Personality Psychology Keynote talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Plomin gave a keynote talk at the World Association for Personality Psychology on Genetics of Intelligence
Year(s) Of Engagement Activity 2016
URL http://www.perpsy.org/meetings/conferences/conference2016/