UKDP: Integrated DEmentiA research environment (IDEA)

Lead Research Organisation: University of Oxford
Department Name: Physiology Anatomy and Genetics

Abstract

The UK Dementias Platform (UKDP) is a radically new approach to dementias research. It brings together data from
around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of
slowing it down. The platform has been funded to the level of £12M.
In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of the
opportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will put
the UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together to
make best use of the equipment.
The three themes of the proposal are imaging, informatics and stem cells.
For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processes
going on inside the brain that cause dementia can be studied.
For informatics we want to be bring together bas many different types of data as possible and make it easy as possible for
scientists to use them
For stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementias
process begins and progresses.
We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, making
the UK an internationally unique place to study dementia.

Technical Summary

Our objective is to achieve a step-change in UK dementia research capacity through establishing national networks of
existing and emerging centres of excellence in imaging, informatics and cell-biology.
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and
cost-effective translational pipeline from discovery through to early phase trials. UKDP will create closer synergy between
epidemiology and experimental medicine with the re-purposing of epidemiologic cohorts for trials readiness. The size and
depth of phenotyping available to UKDP will deliver a step-change in the complexity and granularity of dementia related
hypothesis testing and accelerate compound development.
Proposed here is an infrastructure of investment and collaboration. Underpinning UKDP is a critical mass of researchers
and resources that will work together to encourage, facilitate, and develop a fully integrated dementia dedicated UK
research environment. This will raise standards, reduce costs, and deliver innovative and coordinated research, to make
the UK an internationally unique research environment. Through its partnership with major academic centres and industry,
UKDP is well positioned to achieve this goal.
Building on the recent MRC investment in UKDP, we propose here to renew and extend the UKDP integrative research
environment with an advanced molecular imaging network strategically located to exploit UKDP cohorts. Also proposed is
an integrated informatics environment to facilitate the location of and access to both data and bio-samples. The third
proposal is for a stem-cells network to promote the use of this important and emerging technology. Each of these elements
adds value to existing infrastructure investments and fills significant gaps in the UK research landscape.

Planned Impact

The current proposal in in support of the UKDP and will become part of the the UKDP impact strategy.
In summary, the UKDP strategy to deliver pact is to develop networks of partnership to actively consult engage the UK
academic community in relation to dementia research focussing on the direction,
technologies and collaborations of the UKDP and the wider UK national infrastructure.
Our aim is to:

1) promote the best possible science
2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
Partnership discussions with industry are already underway with exchanges of ides, interests and needs between
academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia
cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to
encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to
leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier
interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not
only to communicate our research findings and their relevance but also to address such issues as stigma in society and the
research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to
communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the
Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE
over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.

Publications

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Andreotti F (2018) Multichannel Sleep Stage Classification and Transfer Learning using Convolutional Neural Networks. in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

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Barber TR (2017) Neuroimaging in pre-motor Parkinson's disease. in NeuroImage. Clinical

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Cherubini M (2018) Convergent pathways in Parkinson's disease. in Cell and tissue research

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Cooray N (2018) Automating the Detection of REM Sleep Behaviour Disorder. in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

 
Description International Advisory Committee for Healthy Brains for Healthy Lives (HBBL), McGill
Geographic Reach North America 
Policy Influence Type Participation in a advisory committee
Impact The $100 million HBBL program seeks to improve the mental helath across Canada across all age groups.
 
Description MRC Dementias Platform UK 'Open Science Champion' and Steering Group member
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL http://www.mrc.ac.uk/research/facilities-and-resources-for-researchers/dementias-platform-uk/governa...
 
Description UK Dementia Platform Executive Committee: Wade-Martins and Lovestone
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Launch of UK Dementia Platform; serve on Executive Committee
 
Description ARUK ODDI collaboration: Phenotypic drug discovery in Parkinson's
Amount £200,000 (GBP)
Organisation University of Oxford 
Department Alzheimer's Research UK Oxford Drug Discovery Institute
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2020
 
Description ARUK Oxford Pilot Investigating the effect of tau on axonal transport and tau release in MAPT-iPSC cortical neuron models
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK Oxford Pilot Optogenetic light source and controller for 96/384-well plates to allow uniform illumination of wells inside a cell-culture incubator.
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK Pilot Analysis of tau secretion in iPS differentiated neuronal cultures
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Autophagic flux 
Amount £317,137 (GBP)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 09/2017 
End 08/2019
 
Description Cerebrovascular health in older adults at a genetic risk for dementia
Amount £3,970 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 08/2018
 
Description Enhancing autophagic flux in Parkinson's disease
Amount $663,000 (USD)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start 10/2017 
End 09/2019
 
Description High content imaging of iPSC-derived neurons to dissect mechanisms of Parkinson's
Amount £80,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2021
 
Description JPND
Amount £350,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 05/2016 
End 05/2019
 
Description MJ Fox Therapeutic Pipeline Program: Enhancing autophagy flux in Parkinson's disease
Amount $330,000 (USD)
Organisation Michael J Fox Foundation 
Sector Charity/Non Profit
Country United States
Start  
 
Description MRC COEN
Amount £150,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 06/2018
 
Description MRC Momentum Award (Microglial interactions in Alzheimer's Disease)
Amount £4,300,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
 
Description MRC Momentum Award (Microglial interactions in Alzheimer's Disease-informatics)
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Partnership Award (Dementias Platform UK Stem Cell Partnership)
Amount £1,200,000 (GBP)
Funding ID MR/N013255/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2016 
End 06/2020
 
Description Mental Health Pathfinder Award
Amount £1,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description NIHR Oxford Health Biomedical Research Centre
Amount £12,800,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start  
 
Description NIHR Oxford Health Clinical Research Facility
Amount £65,686 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start  
 
Description Oxford Biomedical Research Centre (BRC)
Amount £45,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start  
 
Description Oxford Medical Sciences Divisions Returning Carer Fund (Tara Caffrey)
Amount £5,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 02/2017 
End 05/2017
 
Description Sanofi/Genzyme: Modulating GBA activity as a Parkinson's disease therapy
Amount £200,000 (GBP)
Organisation Sanofi 
Department Genzyme Therapeutics Ltd
Sector Private
Country United Kingdom
Start 11/2016 
End 10/2017
 
Description Targeting lysosomes to enhance autophagy in Parkinson's
Amount £201,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 12/2019
 
Description Uniting iPSCS and CRISPR/Cas9 screens- a platform to model and interrogate genetic disease in Oxford
Amount £80,000 (GBP)
Organisation University of Edinburgh 
Department Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 12/2017 
End 06/2019
 
Description Wellcome Institutional Strategic Support Fund: Wellcome Trust Centre for Integrative Neuroimaging
Amount £100,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Centre for Integrative Neuroimaging
Amount £12,500,000 (GBP)
Funding ID 203139/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description What makes strategic stroke strategic? Multimodal imaging and network methods to predict dementia after strategic stroke
Amount £4,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 08/2017
 
Title CRISPR gene editing 
Description We have been able to establish CRISPR/Cas9 gene editing in our lab as a result of this project 
Type Of Material Technology assay or reagent 
Year Produced 2015 
Provided To Others? Yes  
Impact We have been able to perform gene editing in iPSC lines. 
 
Title Dopamine neuron microfluidics 
Description Development of stem cell-derived neuronal culture techniques using microfluidic devices to channel axonal growth. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact Not yet: it is ongoing development 
 
Title Generation of MAPT CRISPR gene edited iPSC lines 
Description We have generated 8 QCed MAPT-­/-­ knockout lines on 2 control backgrounds. 
Type Of Material Cell line 
Year Produced 2018 
Provided To Others? No  
Impact We will use the MAPT-/- iPSC-derived neurons to study the role of MAPT in Parkinson's 
 
Title Generation of SNCA CRISPR gene edited iPSC lines 
Description We have generated 3 QCed SNCA-­/-­ knockout lines on control background and isogenic correction of SNCA Triplication patient line (and also knockout) - clones identified by droplet digital PCR, undergoing confirmatory sequencing. 
Type Of Material Cell line 
Year Produced 2018 
Provided To Others? No  
Impact Generation of SNCA CRISPR gene edited lines will further our work on the role of macrophages and microglia on the uptake/processing/secretion of alpha-­synuclein and its role in stimulating the immune response and enable us to interrogate the mechanism for the phagocytosis defect phenotype observed in the SNCA-­Triplication macrophages/microglia. 
 
Title High content, high throughput analysis 
Description The ability to perform detailed high-throughput analysis of neurons in culture 
Type Of Material Technology assay or reagent 
Year Produced 2016 
Provided To Others? Yes  
Impact Shared use of best practice in high-throughput analysis using Opera Phenix imager and high-throughout plate readers 
 
Title In vitro electrophysiology 
Description Patch-clamp techniques to measure neuronal activity of stem cell-derived neurons 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Analaysis of stem cell-derived neurons: dopamine neurons, cortical neurons, motor neurons and medium spiny neurons 
 
Title Live cell imaging techniques in iPS-derived DA neurons in vitro 
Description We have optimised a live cell imaging protocol for the visualisation and measurement of mitochondrial membrane potential in differentiated neurons. 
Type Of Material Cell line 
Provided To Others? No  
Impact The membrane potential-sensing dye TMRM can be used to quantify membrane potential, with increased fluorescence indicating increased membrane potential. 
 
Title Microglia differentiation 
Description The ability to generate microglia from human stem cells from dementia patients 
Type Of Material Cell line 
Provided To Others? No  
Impact We will be able to compare the function of microglia generated from patients and from controls 
 
Title PLA in stem cell neurons 
Description To enable the detection of a-syn oligomers in stem cell-derived dopamine neurons 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The detection of a-syn oligomers in stem cell-derived dopamine neurons 
 
Title RNA-Seq 
Description Development of methods for analysis of RNA-Seq 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Understanding of gene expression profiles in selected cell population 
 
Title Target discovery assays 
Description Develop target discovery assays using high throughput screens 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact New research facilty built for our work 
 
Title iPSC phenotypic screens 
Description We have developed an organelle calcium flux assay for high-throughput screening and applied the assay to screen 4000 small molecules in Parkinson's patient iPSC-dervied dopamine neurons. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? No  
Impact We will use the assay to identify new therapeutic targets or novel and or repurposable small molecule therapeutics. 
 
Title Imaging Informatics Infrastructure for the dementias platform UK 
Description We have built a federated data sharing platform for imaging data relevant to DPUK using XNAT 
Type Of Material Data handling & control 
Year Produced 2016 
Provided To Others? Yes  
Impact Infrastructure being used by the MRC UK7T partnership, UK 7T network and by the MRC/NIHR Deep & Frequent Phenotyping study, as well as hosting a growing amount of existing cohort imaging data. 
URL https://info.dpuk.org/
 
Description Abeta functional assays 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution We have worked to develop improved in vitro analysis odf Abeta function
Collaborator Contribution Collaborative development of assay
Impact Ongoing collaboration
Start Year 2015
 
Description DPUK Cambridge 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Optimisation of high-content imaging protocols with Opera Phenix imager
Collaborator Contribution The ARUK Stem Cell Research Centre, Cambridge has standardised the use of the Opera Phenix and Nanostring Sprint instruments for QC in iPSC reprogramming and cproduction of cortical neurons. The Phenix is used for high-throughput imaging of pluripotency markers in patient-derived lines that are generated at the centre. The lab has established a method for routine characterisation of cortical neuron productions using the Nanostring digital gene expression platform. This will facilitate harmonisation of protocols between DPUK centres, and within the STEMBANCC consortium. The imaging platform has been used to develop methods for production of human microglia from iPSCs, and to study cell biology in patient iPSC-derived microglia, focussing on TREM2 mutatiosn. In collaboration with Talisman Therapeutics and AstraZeneca, assays have been established to measure protein uptake in cortical neurons by live imaging.
Impact Development of a strong Dementia Stem Cell Network in DPUK
Start Year 2016
 
Description DPUK DSCN 
Organisation Cardiff University
Department School of Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University College London
Department Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Cambridge
Department Gurdon Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Public 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK DSCN 
Organisation University of Manchester
Department Manchester Medical School
Country United Kingdom 
Sector Academic/University 
PI Contribution Forming DPUK Dementia Stem Cell Network
Collaborator Contribution Forming DPUK Dementia Stem Cell Network
Impact Collaborations and interactions
Start Year 2015
 
Description DPUK Data Discovery Tools Categorisation and Coding Programme 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Provide data from our cohort
Collaborator Contribution Create Data discovery tool
Impact Still ongoing
Start Year 2018
 
Description Dementias Platform UK Stem Cell Partnership 
Organisation MRC Dementias Platform UK
Country United Kingdom 
Sector Public 
PI Contribution OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network
Collaborator Contribution Members will share expertise and stem cell lines as part of DPUK Stem Cell Network
Impact Ongoing
Start Year 2016
 
Description Dementias Platform UK Stem Cell Partnership 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network
Collaborator Contribution Members will share expertise and stem cell lines as part of DPUK Stem Cell Network
Impact Ongoing
Start Year 2016
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation McGill University
Department Montreal Neurological Institute and Hospital
Country Canada 
Sector Hospitals 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation National Institutes of Health (NIH)
Country United States 
Sector Public 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation University of Bologna
Department Department of Neurologial Sciences
Country Italy 
Sector Academic/University 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease 
Organisation University of Göttingen
Country Germany 
Sector Academic/University 
PI Contribution Laura Parkkinen and team will analyze CSF samples
Collaborator Contribution Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients.
Impact We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019
Start Year 2018
 
Description ETH Zurich - Oxford collaboration for functional imaging in a rodent model of Parkinson's disease 
Organisation ETH Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution Richard Wade-Martin's lab has engineered the rodent model of Parkinson's disease (human SCA overexpression). This model has been characterized with histology, voltammetry of dopamine release in cell culture, and behaviourally. In collaboration with the Zurich group, Johannes Klein has performed data analysis on the imaging provided by ETH Zurich.
Collaborator Contribution Oxford does not currently have the ability to perform high-quality resting state MRI in small animals. Our collaboration partners at ETH of acquired the imaging data, performed pre-processing with motion correction and ICA data cleaning. Together, we have analysed differences in brain networks between mice overexpressing human alpha-synuclein, and alpha-synuclein knockout siblings.
Impact The research is ongoing. The imaging data will be published in the coming year.
Start Year 2015
 
Description Electrophysiology in iPSC neurons 
Organisation University of Oxford
Department Department of Pharmacology
Country United Kingdom 
Sector Academic/University 
PI Contribution We have worked to establish electrophysiology analysis of iPSC-derived cortical neurons
Collaborator Contribution Helped us to establish the technique
Impact Ongoing collaboration
Start Year 2014
 
Description Enhancing autophagy flux in Parkinson's disease 
Organisation AstraZeneca
Department Astra Zeneca
Country United States 
Sector Private 
PI Contribution OPDC test drug like molecules in cellular models of Parkinson's
Collaborator Contribution Astra Zeneca to provide drug-like small molecules.
Impact Ongoing
Start Year 2016
 
Description Evaluation of selected CSF proteins as prognostic markers of dementia in patients with Parkinson's disease 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Provision of samples from our cohort
Collaborator Contribution Measuring two serum proteins (haptoglobin and homocysteine), as well as two cerebrospinal fluid proteins (Aß1-42 and phospho-tau).
Impact Ongoing research
Start Year 2016
 
Description Free living walking behaviour in a cohort of people with RBD 
Organisation Newcastle University
Department Institute of Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution applying the Axivity Device to RBD and Control participants attending Discovery clinic and providing clinical data
Collaborator Contribution Further analysis of data to look for evidence of the onset of motor-symptoms.
Impact Ongoing research
Start Year 2016
 
Description Lysosomal dysfunction and glycosphingolipid dysregulation in Parkinson's 
Organisation University of Oxford
Department Department of Pharmacology
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided serum samples from our cohort
Collaborator Contribution analyse serum/plasma and CSF from PD patients, at-­risk patients and control cases as our aims are to characterise the pattern of expression of GSLs in PD and to search for lipid biomarkers
Impact Ongoing research
Start Year 2016
 
Description Neurochip Task Force Genetics Study 
Organisation German Centre for Neurodegenerative Diseases
Country Germany 
Sector Public 
PI Contribution All study members to genotype their cohort on same chip
Collaborator Contribution Sharing genomic data between cohorts with OPDC and Centre PD
Impact Still active
Start Year 2018
 
Description Neurochip Task Force Genetics Study 
Organisation University of Luxembourg
Department Faculty of Science, Technology and Communication
Country Luxembourg 
Sector Academic/University 
PI Contribution All study members to genotype their cohort on same chip
Collaborator Contribution Sharing genomic data between cohorts with OPDC and Centre PD
Impact Still active
Start Year 2018
 
Description ODDI Phenotypic drug discovery in Parkinson's 
Organisation University of Oxford
Department Alzheimer's Research UK Oxford Drug Discovery Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Collaborative drug discovery project in Parkinson's
Collaborator Contribution Collaborative drug discovery project in Parkinson's
Impact Ongoing
Start Year 2017
 
Description Oxford collaboration for molecular imaging (PET) in a rodent model of Parkinson's disease. 
Organisation University of Oxford
Department Department of Oncology
Country United Kingdom 
Sector Academic/University 
PI Contribution Richard Wade-Martins' lab has engineered rodent models of Parkinson's disease: LRRK2 BAC transgenic rats expressing human wild-type, G2019S, or R1441C LRRK2 mutations. These models have been extensively characterised using behavioural tests, voltammetry, electrophysiological recordings and immunohistochemistry analyses, showing that transgenic rats aged 18-21 months bearing any of the LRRK2 mutations exhibit L-DOPA responsive motor dysfunction, impaired striatal dopamine release, and cognitive deficits, but with no apparent neurodegeneration or protein accumulation on histology. In collaboration with the Imaging Core at the Oncology Department, we have optimised a scanning protocol for the aged rat-cohorts that will allow the acquisition of 18F-DOPA PET data to further characterise the effect of these mutations on dopamine metabolism, and validate these rodent models for future imaging studies. The aim is to provide early imaging readouts for the response to therapy with candidate compounds in an animal model of the early stages of PD.
Collaborator Contribution This collaboration allows us to bring new methods to OPDC. Our collaborators provide the radiotracers needed to perform our molecular imaging studies (fluorodopa is not routinely produced or distributed), and the facilities and expertise to run our scans. Veronique Gouverneur's lab has pioneered a new synthesis route for fluorodopa, and they are currently working to scale it up to production level for us. Sean Smart and Veerle Kersemans run the PET facility at the Oncology Department and have optimised the imaging logistics, and helped with acquisition protocols and data reconstruction so we are able to scan our aging cohorts in time.
Impact Initial pilot studies have been performed to detect and address imaging-specific problems before starting the analysis of the transgenic cohorts. The dose and injection timing of aromatic amino acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT) inhibitors (benserazide and entacapone respectively), have been optimised to avoid fluorodopa metabolism outside the brain. The dose of radiotracer and scanning timings are currently under investigation with further pilot scans. We will start imaging the transgenic cohorts at the beginning of 2018, and we anticipate to complete data acquisition and analysis by the end of the year. With the outputs generated from this research, we will be able to apply for further funding to advance our use of molecular imaging for model characterisation and, in the future, for studies evaluating promising candidate compounds to modify disease progression.
Start Year 2016
 
Description Oxford collaboration for molecular imaging (PET) in a rodent model of Parkinson's disease. 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Richard Wade-Martins' lab has engineered rodent models of Parkinson's disease: LRRK2 BAC transgenic rats expressing human wild-type, G2019S, or R1441C LRRK2 mutations. These models have been extensively characterised using behavioural tests, voltammetry, electrophysiological recordings and immunohistochemistry analyses, showing that transgenic rats aged 18-21 months bearing any of the LRRK2 mutations exhibit L-DOPA responsive motor dysfunction, impaired striatal dopamine release, and cognitive deficits, but with no apparent neurodegeneration or protein accumulation on histology. In collaboration with the Imaging Core at the Oncology Department, we have optimised a scanning protocol for the aged rat-cohorts that will allow the acquisition of 18F-DOPA PET data to further characterise the effect of these mutations on dopamine metabolism, and validate these rodent models for future imaging studies. The aim is to provide early imaging readouts for the response to therapy with candidate compounds in an animal model of the early stages of PD.
Collaborator Contribution This collaboration allows us to bring new methods to OPDC. Our collaborators provide the radiotracers needed to perform our molecular imaging studies (fluorodopa is not routinely produced or distributed), and the facilities and expertise to run our scans. Veronique Gouverneur's lab has pioneered a new synthesis route for fluorodopa, and they are currently working to scale it up to production level for us. Sean Smart and Veerle Kersemans run the PET facility at the Oncology Department and have optimised the imaging logistics, and helped with acquisition protocols and data reconstruction so we are able to scan our aging cohorts in time.
Impact Initial pilot studies have been performed to detect and address imaging-specific problems before starting the analysis of the transgenic cohorts. The dose and injection timing of aromatic amino acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT) inhibitors (benserazide and entacapone respectively), have been optimised to avoid fluorodopa metabolism outside the brain. The dose of radiotracer and scanning timings are currently under investigation with further pilot scans. We will start imaging the transgenic cohorts at the beginning of 2018, and we anticipate to complete data acquisition and analysis by the end of the year. With the outputs generated from this research, we will be able to apply for further funding to advance our use of molecular imaging for model characterisation and, in the future, for studies evaluating promising candidate compounds to modify disease progression.
Start Year 2016
 
Description Rodent fMRI imaging 
Organisation ETH Zurich
Country Switzerland 
Sector Academic/University 
PI Contribution OPDC provides mouse models of Parkinson's
Collaborator Contribution ETH carries out fMRI scanning on mice
Impact Ongoing project
Start Year 2016
 
Description Stem cell generation 
Organisation University of Oxford
Department Sir William Dunn School of Pathology
Country United Kingdom 
Sector Academic/University 
PI Contribution We work with the Oxford Stem Cell Facility at Pathology to study induced pluripotent stem cells of certain MAPT genotypes
Collaborator Contribution The Stem Cell Facility provides stem cells of certain MAPT genotypes for differentiation into neurons
Impact None yet
Start Year 2012
 
Description Structural and functional connectivity in the human basal ganglia in health and disease using high resolution MRI at 7T 
Organisation University of Oxford
Department Nuffield Department of Clinical Neurosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution FMRIB scans and clinical data from our cohort
Collaborator Contribution Investigate in vivo connectivity of human basal ganglia.
Impact Ongoing research
Start Year 2016
 
Description T cell reactivity to alpha-synuclein 
Organisation Celgene
Country United States 
Sector Private 
PI Contribution Interaction with Celgene scientists on Parkinson's immuniology
Collaborator Contribution Mentorship of early career researcher
Impact New post-doc appointed
Start Year 2019
 
Description The genetic background of REM sleep behaviour disorder and its conversion to synucleinopathies. 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Providing DNA samples from our cohort
Collaborator Contribution Analsying with 2 plaforms using advanced genetic methods.They have already analysed about 500 RBD patients, 600 PD patients and about 1000 controls, with very encouraging results.
Impact Ongoing research
Start Year 2017
 
Description Twinning: Centre PD 
Organisation University of Luxembourg
Department Faculty of Science, Technology and Communication
Country Luxembourg 
Sector Academic/University 
PI Contribution OPDC will share information on clinical cohorts, stem cells and neuropathology
Collaborator Contribution Centre PD will share information on clinical cohorts, stem cells and neuropathology Centre PD worked with us on the EU Twinning grant to facilitate OPDC clinical data base move from Open Clinica to Red Cap System
Impact Ongoing
Start Year 2015
 
Description UK Dementia Platform (DPUK) 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Many OPDC members play a leading role in the DPUK. Richard Wade-Martins head the DPUK National Dementia Stem Cell Network, Simon Lovestone heads Informatics component and Clare MacKay leads on informatics analysis of imaging. Richard and Simon are on thr DPUK Executive Committee.
Collaborator Contribution The MRC Dementias Platform UK (DPUK) is a £53M public-private partnership, developed and led by the Medical Research Council, to accelerate progress in, and open up, dementias research. The DPUK's aims are early detection, improved treatment and ultimately, prevention, of dementias.
Impact The DPUK launched in Autumn 2014. It is directed by Dr John Gallacher at the University of Cardiff, together with an executive team of investigators drawn from seven universities (Cambridge, Edinburgh, Imperial College London (ICL), Oxford, Newcastle, University College London (UCL) and Swansea), including the UCL-based MRC Unit for Lifelong Health and Ageing. The clinical research infrastructure award links DPUK with further universities, Manchester and Bristol.
Start Year 2014
 
Description "How our brains work" Clare MacKay 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Clare MacKay conducted "how our brains work" activities during Brain Awareness Week at Hagbourne CofE Primary school (02/16). Each class in turn was given an age-appropriate talk on the neuroscience of a 'growth mindset'. Clare MacKay also gave 'neuroscience for teachers' and 'Growth Mindset for parents' talks for the school.
Year(s) Of Engagement Activity 2016
URL https://www.facebook.com/hagbourneschool/posts/953838178043436
 
Description "The Funny Side of Parkinson's" 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact "The Funny Side of Parkinson's" on BBC1. Paul Mayhew-Archer Documentary.
Richard Wade-Martins and Fahd Baig appeared to talk about OPDC.
Paul was named best presenter at the Grierson Awards for this documentary.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/iplayer/episode/b072xkcz/inside-out-south-parkinsons-the-funny-side
 
Description #DementiaActionWeek2018 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sharing content to promote #DementiaActionWeek2018 including producing original video of researcher
Year(s) Of Engagement Activity 2018
URL https://twitter.com/WadeMartinsLab/status/999632001920651264
 
Description 2018 article published on iPS research in Oxford in Phenotype (Oxford Biochemical society magazine) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A decade of IPS cell research in Oxford by Sally Cowley
Phenotype is the magazine of the Oxford University Biochemical Society. It is run by students and staff and published on a termly basis.
Year(s) Of Engagement Activity 2018
URL https://issuu.com/phenotypejournal/docs/mt18
 
Description 2018/19 OPDC Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We produced a newsletter on OPDC activities.
This was sent to all study participants, those on OPDC news mailing list and will be handed out at events.
Year(s) Of Engagement Activity 2018,2019
URL https://www.opdc.ox.ac.uk/_asset/file/opdc2018-19-newsletter.pdf
 
Description A-Level workshop in the Oxford Natural History museum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A-Level workshop in the Oxford Natural History museum March 2017 Naiara Demnitz
Year(s) Of Engagement Activity 2017
 
Description ARUK Network Open Morning 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact About 150-200 people attended a morning of talks from Oxford researchers, including presentations on using stem cells in dementia research.
Year(s) Of Engagement Activity 2015,2016
 
Description ARUK Oxford network dementia information event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Open day of talks and information stands organised by Alzheimer's UK Oxford Research Network at John Radcliffe Hospital.
Talk by Sana Suri on Brain-Heart links
Year(s) Of Engagement Activity 2018,2019
URL https://www.oxdare.ox.ac.uk/public-events
 
Description ARUK YouTube Channel 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact You tube channel for Alzhiemer's Research UK Oxford network centre. Includes talks from open days, panel discussions and short Q&A videos.
Year(s) Of Engagement Activity 2015,2017,2018
URL https://www.youtube.com/channel/UCU_wr013kmYXypvNCRzU3JA
 
Description ARUK/BRC Oxford Dementia Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact a day of talks celebrating the exciting research in the region including updates on some of the exciting big dementia research initiatives such as the ARUK Oxford Drug Discovery Institute, Dementia Platform UK, the NIHR Oxford Health Biomedical Research Centre and the Oxford Momentum Award. Accredited for 5 CPD credits.
Year(s) Of Engagement Activity 2017
URL https://www.dpag.ox.ac.uk/research/wade-martins-group/oxford-aruk-network-centre/research-day-2015
 
Description Academic Health Science Networks Webinar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Clare Mackay was invited to preset an AHSN Webinar in June 2017
Year(s) Of Engagement Activity 2017
URL http://atlas.ahsnnetwork.com/
 
Description Annual meeting of Organization for Human Brain Mapping (OHBM), Vancouver 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Vaanathi Sundaresan:Poster: "Modelling white matter hyperintensities distribution within a population using Bayesian Inference." Eniko Zsoldos: Poster: 'Mid-life composite measures of biological aging predict structural integrity measures in later life'. Johannes Klein Poster "Prefrontal network dysfunction in prodromal and manifest Parkinson's disease"
Year(s) Of Engagement Activity 2017
 
Description Attend Parkinson's UK engagement event at St James' Palace, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Attend reception at St James' Palace to raise awareness for Parkinson's disease
Year(s) Of Engagement Activity 2018
 
Description BBC One Saturday Breakfast News - Funny Side of Parkinson's 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Richard Wade-Martins appeared on BBC One Saturday Breakfast News with Paul Mayhew-Archer to discuss our research using stem cell technology to grow and study dopamine neurons from skin cells.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/health-35734888
 
Description Blog by Bryan Ng on DPUK website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on DPhil student Bryan Ng's project in Richard Wade-Martins' lab.
Disease-in-a-dish studies open a window to a new level of detail in dementia
Year(s) Of Engagement Activity 2019
URL https://www.dementiasplatform.uk/blog/disease-in-a-dish-studies-open-a-window-to-a-new-level-of-deta...
 
Description British Neuroscience Association Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Sana Suri: Talk: British Neuroscience Association Conference, Birmingham April 2017: "The APOE Paradox"
Year(s) Of Engagement Activity 2017
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Hands-on experiments, the MakerShack, our brand new Cyber Zone, heartbeat art there was much to explore on site in 2018!

From stargazing, fun activity trails, family days and heated discussions in the Conversation Corner to a large animal dissection live on the Festival site, Cheltenham Science Festival offers science galore for all ages.

Dr Tara Caffrey took part in the day to talk about her research into Tau.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science
 
Description Clare Mackay talk - New developments in Parkinson's and Alzheimer's research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact OPDC's Imaging lead Professor Clare Mackay and Masud Husain, Professor of Neurology and Cognitive Neuroscience, spoke at a talk open to all about "New developments in Parkinson's and Alzheimer's research".

In this accessible and informative public talk they explored the latest research into the debilitating neurodegenerative disorders Alzheimer's and Parkinson's. They showed how cutting edge research is: increasing our knowledge of the mechanisms causing these disorders, offering the prospect of earlier diagnosis and supporting the development of potential new therapies to slow the progression of the disease.
The talk was filmed as is available to view online
Year(s) Of Engagement Activity 2018
URL https://youtu.be/WtmCPdTdmPc
 
Description Creation of wademartinslab_oxford instgram account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Account for Wade-Martins lab for Molecular Neurodegeneration, University of Oxford to share news
Year(s) Of Engagement Activity 2018,2019
URL https://www.instagram.com/wademartinslab_oxford/
 
Description DPUK Stakeholders Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Raised awareness of use of stem cells in dementia research
Year(s) Of Engagement Activity 2015
 
Description DPUK Website feature iPSCs: a shared resource 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Information on iPSC labs on DPUK website accessible in the "For Researchers" tab then "Our Research Communities"
Year(s) Of Engagement Activity 2018,2019
URL https://www.dementiasplatform.uk/our-impact/ipscs-a-shared-resource
 
Description Daybreak Lectures on issues around dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Phillippa Carling gave a brief overview of her work on drug discovery lab at ODDI, with some videos of some of their equipment.
Year(s) Of Engagement Activity 2018
 
Description Dementia Awareness Morning - Bryan Ng 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Bryan Ng helped out at a dementia awareness event at the John Radcliffe Hospital.
This was a morning of talks about research into dementia in and around Oxford and a chance for the public to meet researchers and find out about support services available for people living with dementia.
Year(s) Of Engagement Activity 2018
URL https://www.oxdare.ox.ac.uk/public-events
 
Description Downing Street 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Inivitation to attend reception at 10, Downing Street
Year(s) Of Engagement Activity 2017
 
Description Editorial from Tim Greenamyre on our paper on what's wrong with Mitochondria in Parkinson's 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Editorial in Movement Disorders Journal on our publication
Year(s) Of Engagement Activity 2018
URL https://www.ncbi.nlm.nih.gov/pubmed/30288798
 
Description Gordon Research Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Nora Bengoa-Vergniory "Mass-spectrometry approach highlights REST as a potential neuroprotective target for Parkinson's disease in an alpha synuclein overexpressing BAC-transgenic mouse model" Oral presentation Posters: Nora Bengoa-Vergniory, Dayne Beccano-Kelly, Natalie Connor-Robson, Rebecca Wallings
Year(s) Of Engagement Activity 2017
URL https://www.grc.org/parkinson-s-disease-conference/2017/
 
Description Guest speaker at Alzheimer's Society Dementia Cafe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Sana Suri - Talk: guest speaker at Alzheimer's Society Dementia Cafe, Oxford September 2017: "The heart-brain link in dementia"
Year(s) Of Engagement Activity 2017
 
Description Health Canal article based on HDAC4 paper 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Online news article on HDAC4 paper based on Parkinson's UK press release
Year(s) Of Engagement Activity 2018
URL https://www.healthcanal.com/brain-nerves/parkinson/247111-experimental-cancer-drug-shows-promise-for...
 
Description Interactive workshop on "The Upside-down Brain" at the Ashmolean museum 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Sat 18 March, All day
The Upside-Down Brain: Art and Neuroscience at the Ashmolean Family Friendly Event. Naiara Demnitz
Year(s) Of Engagement Activity 2017
URL https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwjE172jjO...
 
Description Interview in Civil Service Fast Stream blog - How Stem Cells Can Boost Our Knowledge and Understanding of the Causes of Dementia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This is the third and final in a series of interviews carried out by a group of civil servants that have dedicated time to raising money and awareness for dementia via 'The Fund', a Fast Stream initiative. Alison Leishman, Home Office, interviewed Professor Wade-Martins about his research into dementia.
Richard discussed OPDC and the DPUK.
Year(s) Of Engagement Activity 2016
URL https://faststream.blog.gov.uk/2016/05/20/the-fascinating-world-of-research/
 
Description Mark Kelly Parkinson Voice Project lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Mark Kelly spoke at a Parkinson Voice Project lecture presented in the Clark and Brigid Lund Parkinson's Education Center. The talk was streamed live and is available online.

This lecture explores what we know so far about impulse control behaviours in Parkinson's and takes a look at work being carried out by the Oxford Discovery Project to better understand these effects. This knowledge helps not only in better directing available therapies, but also improves our understanding of some of the underlying pathological processes involved in Parkinson's.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/impulse-control-behaviours-and-creativity-in-parkinson-s
 
Description Medical Express article on HDAC4 paper 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on HDAC4 publication based on Parkinson's UK press release.

Medical Xpress is a web-based medical and health news service that is part of the renowned Science X network. Based on the years of experience as a Phys.org medical research channel, started in April 2011, Medical Xpress became a separate website.

Branching out with Phys.org's monthly 2.5 million readership, Medical Xpress features the most comprehensive coverage in medical research and health news in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.

Readers of Medical Xpress will have access to the same features offered on Phys.org, such as article comments, ranking, the ability to save favorite articles, a personal account page, easy sharing, podcasts, iPhone/iPad/Android apps and other options.

Readers may follow Medical Xpress on Facebook, Twitter or through a variety of customizable RSS feeds and e-Newsletter for the latest in medical research and health news.
Year(s) Of Engagement Activity 2018
URL https://medicalxpress.com/news/2018-12-experimental-cancer-drug-parkinson.html
 
Description Neurogune talks, Bilbao Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact "Alpha-synuclein overexpressing mice and protection of neurons from synuclein toxicity by molecular tweezers" Oral presentation Nora Bengoa-Vergniory
Year(s) Of Engagement Activity 2017
 
Description New Atlas online article on HDAC4 press release 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on HDAC4 paper based on the press release from Parkinson's UK
Year(s) Of Engagement Activity 2018
URL https://newatlas.com/experimental-cancer-drug-parkinsons/57481/
 
Description Nora Bengoa-Vergniory article on Celgene Fellowship 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Interviwe with Dr Nora Bengoa-Vergniory on her experience as a Celgene Fellow for the Oxford University Medical Sciences division website
Year(s) Of Engagement Activity 2018
URL https://www.medsci.ox.ac.uk/research/internal/funding-directory/oxford-celgene-fellowship/oxford-cel...
 
Description OPDC Facebook Page 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Creation of OPDC Facebook page. Used to update on OPDC activity. Focus on outreach events, but also includes news about publications etc. Also used boosted posts to promote OPDC open day.
Year(s) Of Engagement Activity 2017,2018,2019
URL https://www.facebook.com/OxfordPDCentre/
 
Description OPDC Newsletter Summer 2017 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We have produced a 12 page newsletter with updates on our recent activities. This includes OPDC research news, outreach activities and news from members of the cohort and Parkinson's UK. The newsletter is posted to all cohort members and emailed to those on the news mailing list. It is also available online.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/newsletters
 
Description OPDC Open Day 2016 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact OPDC Open Day 2016
250 OPDC study Participants and Partners registered for event.
Day of talks from Michele Hu, Fahd Baig, Claudio Ruffmann, Tom Barber and Richard Wade-Martins.
Discussion of what participants would like from study.
Talks filmed and podcasts added to website
Year(s) Of Engagement Activity 2016
URL http://www.opdc.ox.ac.uk/openday2016
 
Description OPDC Open Day 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact We held an afternoon of talks and invited members of our cohort, their supprters, and members of the Thames Valley Parkinson's UK Excellence Network to attend. Around 200 people registered for the event and the feedback was largey positive. We have moved to a larger venue out of the city centre to allow us to offer parking. Talks were filmed and are available on our website and YouTube channel. Speakers at the event were Michele Hu, Mark Kelly, James Cantley, Tom Barber, Christine Lo, Sally Cowley and Richard Wade-Martins.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/openday2017
 
Description OPDC Open Day talks online 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact A series of talks recorded at the 2018 OPDC Particpant's day are available to view on our YouTube channel and on our website.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/videos
 
Description OPDC Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact We held a research day to present an update on current Parkinson's research in the region and invited members of our SAB from overseas to present their work.
This was attended by researchers from accross Oxford as well as members of the local Parkinon's UK group and interested study participants.
We invited Hazel Stanyon, a study partiicpants who apoke about her experiences of how exercise has helped her Parkinson's symptoms and shared a poem.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/research2018
 
Description OPDC Research Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact The OPDC Research Day is a one-day event with research talks from world leading Parkinson's researchers on topics including clinical studies, imaging, genetics, proteomics, neuronal cells and animal models.
The 2017 OPDC Research Day was held in the Medical Sciences Teaching Centre, Oxford.
There was a full day of talks and poster sessions on Parkinson's research.
This one-day event included research talks by national and international keynote speakers and Oxford researchers on a range of Parkinson's work including clinical studies, imaging, genetics, proteomics, neuronal cell culture and animal models.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/research2017
 
Description OPDC YouTube channel 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Creation of OPDC YouTube channel to collate our podcasts etc.
32 subscribers, >2,860 views Feb 2016-Jan 2017.
2016 talks >1,450 views,
2016 OPDC highlights video >350 views,
2015 talks >1,000 views
Year(s) Of Engagement Activity 2015,2016
URL http://www.youtube.com/channel/UCGzboizARwaAUFW5FjPmmZw
 
Description OPDC welcomes Participants to Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact On September 10th, 2018 over 200 members of Discovery cohort came to the Jury's Inn, Oxford to hear about our latest research and share their views. We would like to thank all of the cohort members who came to the event from our centres across the country, and joined in the lively discussion session.

Researchers from across OPDC's themes shared their work. These included talks on our work to develop a new test for Parkinson's, how we are using skin biopsy samples from our cohort to look for new potential therapies and new drugs trials on our horizon, our work to improve sleep studies, how we are working with other large studies of people with Parkinson's to better define Parkinson's and our work on dyskinesia. We also heard about a new survey to define top priorities for Parkinson's research and heard more about the brain donation process.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/opdc-welcomes-participants-to-open-day
 
Description On-line collaboration tool 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact In support of the broader collaboration aims of the UKCRIS programme, an online portal has been designed and launched to facilitate programme partners ability to share research interests and provide opportunities for virtual forums enabling pre research collaboration together with private workspace for collaboration projects to be progressed. Additionally the site provides a facility for the general public to be aware of research activities in the fields of mental health and dementias.
Year(s) Of Engagement Activity 2016,2017
URL https://crisnetwork.co
 
Description Oxford Science Festival Information Stand 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Oxford Science Festival, June 2016 (Clare MacKay manned a stand)
Year(s) Of Engagement Activity 2016
URL http://www.oxfordshiresciencefestival.com/
 
Description Oxford Sleep Study #OxfordAI video 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Sleep study on wearable technology chosen by Oxford University team for a feature video as part of their OxfordAI series.
Coverage on Oxford University website, twitter and facebook feeds.
Year(s) Of Engagement Activity 2018
URL https://www.facebook.com/the.university.of.oxford/videos/2136127846704050/
 
Description Oxford Sparks'animation about the role of microglia in neurodegeneration 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Postdoc Hazel Roberts won Oxford Sparks' competition to have an animation made about the role of microglia in neurodegeneration. Title: Discovering life-changing dementia treatments.

Your beautiful, complex brain is a network of microscopic cells that connect together to form your thoughts and personality, and control your body. The network is fragile and requires constant upkeep, like a garden. The brain has its own gardeners, specialised cells called microglia. In this animation we look at how researchers at the University of Oxford are developing drug treatments for Alzheimer's disease, by harnessing the power of the brain's microglia.
Year(s) Of Engagement Activity 2018
URL https://www.oxfordsparks.ox.ac.uk/content/discovering-life-changing-dementia-treatments
 
Description Oxford University article on HDAC4 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on front page on Oxford University website based on HDAC4 pressrelease from parkinson's UK
Year(s) Of Engagement Activity 2018
URL http://www.ox.ac.uk/news/2018-11-30-experimental-cancer-drug-shows-promise-parkinson%E2%80%99s
 
Description Parkinson's Documentary - Kent University 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Richard Wade-Martins interview with Isabelle Miller, a journalist at the University of Kent for a documentary about young people who have Parkinson's (20s-30s).
To be produced Mar 2018

------

A bit more about the documentary:

It will be a 15-30 minute long-from television documentary.

A lot of people forget that it occurs in young people as well as older people, although less common. I want to educate people on how individual it really is, as well as raise awareness, therefore gaining more support. I also want people to see how a young person adapts their life to the condition.

Having Parkinson's at a working age is a whole different challenge compared to those who have it later in life. Some have to stop working, some are determined to continue and be a part of the ever-developing research.

I want to show people that, yes, it is difficult to live with Parkinson's, and research into YOPD needs to be funded further, however, I also want to show how people make life their own. It would be an insight into both the struggles and normalities people with Parkinson's face.

This is a topic which has light and shade for viewers and will serve a great purpose in informing those who need the information.
Year(s) Of Engagement Activity 2017,2018
 
Description Parkinson's Life online article on HDAC4 press release 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on research paper based on press relelase from Parkinson's UK
Year(s) Of Engagement Activity 2018
URL https://parkinsonslife.eu/repurposed-cancer-drug-parkinsons/
 
Description Parkinson's Oxford Walk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact Members of OPDC took part in Parkinson's UK Oxford Walk. OPDC also hosted an information stand at the event.
Year(s) Of Engagement Activity 2018
URL https://www.parkinsons.org.uk/events/walk-parkinsons-oxford
 
Description Parkinson's UK Blog Post on HDAC paper 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Blog by Claire bale on Parkinson's UK Blog
Using brain cells grown from skin to find new potential drugs
Researchers in Oxford are using pioneering stem cell techniques to understand the earliest problems that occur inside brain cells in Parkinson's - and hunt down new drugs that can tackle them.
Year(s) Of Engagement Activity 2018
URL https://medium.com/parkinsons-uk/using-brain-cells-grown-from-skin-to-find-new-potential-drugs-78f56...
 
Description Parkinson's Walk 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Members of OPDC took part in the Oxford Parkinson's Walk. Melanie Witt and Jane Rumbold manned an information stand with literature about our work and sign up sheets for infomration about participating in research. Taking part were Michele Hu, Richard Wade-Martins, Sally Cowley, Paul Bolam, Amandine Louvel, Tom Barber, Ludovica Griffanti, Marie Crabbe, ChristineLo, Johannes Klein, Jane Rumbold, Charmaine Lang and Rebecca Wallings.
Year(s) Of Engagement Activity 2017
URL http://www.opdc.ox.ac.uk/opdc-joins-parkinson-s-uk-2017-oxford-walk
 
Description Pete Magill welcomes Lord O'Shaughnessy, Parliamentary Under-Secretary of State for Health to OPDC & MRC BDNU 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact The Medical Research Council Brain Network Dynamics Unit at the University of Oxford recently welcomed Lord James O'Shaughnessy, Parliamentary Under-Secretary of State for Health, for a site visit organised as part of The Royal Society's Pairing Scheme that OPDC theme 3 co-lead Professor Pete Magill is taking part in.

The visit began with Unit Group Leaders Peter Brown, Peter Magill and Tim Denison highlighting why, how and where the Unit undertakes its cross-disciplinary research incorporating experimental neuroscience, clinical studies and bioengineering. This prompted some insightful discussion on the Unit's contribution to the UK's research and innovation landscape, as well as its alignment with government policy and strategy. Lord O'Shaughnessy then toured Unit facilities, and met with some of the Unit's early-career scientists who showcased the concepts and technologies underpinning their respective experiments. After lunch, Lord O'Shaughnessy visited Unit research collaborators at the Oxford Parkinson's Disease Centre and the ARUK Oxford Drug Discovery Institute.

Peter Magill commented, "Lord O'Shaughnessy's visit was an invaluable opportunity for us to engage and to be engaged. The mutual exchange of knowledge was both invigorating and enlightening. I can highly recommend the Pairing Scheme to other scientists and policymakers."
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/pete-magill-welcomes-lord-o-shaughnessy
 
Description Pint of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Gave a talk in a pub about the use of stem cells in dementia research
Year(s) Of Engagement Activity 2015
 
Description Poster at Advances in Neurodegenerative Disease Research and Therapy/New Frontiers in Neuroinflammation Keystone Conference, Colorado USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Nora Bengoa-Vergniory poster
"Tau-proximity ligation assay detects pathology ahead of tau neurofibrillary tangles in Alzheimer's disease"

As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.
Year(s) Of Engagement Activity 2018
URL http://www.keystonesymposia.org/18Z3
 
Description Presentation on Ageing Research for A-Level students at the UNIQ Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Presentation on Ageing Research for A-Level students at the UNIQ Summer School - https://www.psych.ox.ac.uk/team/naiara-demnitz
Year(s) Of Engagement Activity 2017
URL http://www.uniq.ox.ac.uk/
 
Description Primary School Tours of FMRIB Scanner 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Primary schools invited onto tours of the Oxford Centre for Functional MRI of the Brain (FMRIB).
Year(s) Of Engagement Activity 2017
URL http://www.oum.ox.ac.uk/braindiaries/
 
Description Pub quiz in aid of Parkinson's Research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Siv Vingill, Melanie Witt, Dayne Beccano-Kelly, Nora Bengoa-Vergniory and Melanie Witt took part in pub quiz held at the Barleycorn pub near Andover raising funds for Parkinson's research in Oxford. They met with supporters and talked about their work.
Year(s) Of Engagement Activity 2018
URL https://www.opdc.ox.ac.uk/oxford-parkinson-s-disease-centre-members-raise-funds-for-their-research-a...
 
Description Radio Interviews on Parkinson's 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Radio interview to raise awareness and Parkinson's fund raising sponsored event

Raised awareness and money
Year(s) Of Engagement Activity 2015
 
Description Section on DPUK website to formally request stem cell lines 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact A section on iPSC resources for researchers on the DPUK website provides the opportunity for researchers to formally request over 100 stem cell lines derived from healthy and diseased individuals. This resource focused section is complemented by two detailed reports in the "Our impact" section of the web-site.
Year(s) Of Engagement Activity 2018,2019
URL https://www.dementiasplatform.uk/for-researchers/expert-communities-1/stem-cells-network-1/ipsc-reso...
 
Description Short video on Smartphone app #OxfordAI 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact OPDC approached by Oxford University to make a film about our smartphone app to monitor Parkinson's.
Film produced as part of #OxfordAI campaign and released onto Oxford University twitter (>486k followers), Facebook (>3.5M followers) and website.
Year(s) Of Engagement Activity 2018
URL https://www.facebook.com/the.university.of.oxford/videos/2153105401670113/UzpfSTIzMzAxMDc0MDQ3ODAyNz...
 
Description Speaker at launch of UK Dementia Platform 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Oxford plays a significant role in the partnership and Oxford Neuroscience researchers lead a number of projects. This was reflected in the scientific programme of launch day. Simon Lovestone (Psychiatry) gave a talk on the NIHR-MRC Dementia Deep and Frequent Phenotyping Feasibility Study while Richard Wade-Martins (DPAG) spoke on the UK Stem Cell Network.

Coverage in the media
Year(s) Of Engagement Activity 2014
URL http://www.dementiasplatform.uk/
 
Description Talk at Parkinson's UK Branch Richard Wade-Martins 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Prof Richard Wade-Martins on the latest projects at the Oxford Centre for Parkinson's Disease Research
Year(s) Of Engagement Activity 2016
 
Description Thames Valley Parkinson's Excellence Network Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Newsletter for the TVEN distributed at Parkinson's clinics and at events.
Year(s) Of Engagement Activity 2016
URL http://www.opdc.ox.ac.uk/_asset/file/tv-excellence-network-newsletter-june-2016.pdf
 
Description Twitter account for OPDC 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Active twitter feed for OPDC engages with other research groups and industry.
Promotes our research, events, news and drives for study participants as well as highlighting relevant news items and publications.
Jan 2019: 829 followers, average Impressions 10.6k per month
Year(s) Of Engagement Activity 2015,2016,2017,2018,2019
URL http://twitter.com/OxfordPDCentre
 
Description UKCRIS data linkage model 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact An important element of the UKCRIS informatics programme has been the development and agreement of a design and governance model for data linkage between the CRIS secondary caredata set and UK BioBank. This represents a significant capability gain for research studies utilising real world data.
Year(s) Of Engagement Activity 2015
 
Description Work with artist to produce cartoons of research 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Abstracts of posters were presented by DPAG Graduate Students at the start of their Second Year of DPhil Research Study. A cartoonist was on hand again to record the event and produced cartoons to illustrate the projects which were shared via social media.
Year(s) Of Engagement Activity 2018
URL https://twitter.com/WadeMartinsLab/status/1074587251496095745
 
Description led a session on macrophages and microglia in a Stem Cell Outreach workshop for GCSE school students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Sally Cowley led a session on macrophages and microglia in a Stem Cell Outreach workshop for GCSE school students, Medical Sciences Teaching Centre, Oxford University
Year(s) Of Engagement Activity 2018