UKDP: Integrated DEmentiA research environment (IDEA)
Lead Research Organisation:
University of Oxford
Department Name: Physiology Anatomy and Genetics
Abstract
The UK Dementias Platform (UKDP) is a radically new approach to dementias research. It brings together data from
around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of
slowing it down. The platform has been funded to the level of £12M.
In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of the
opportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will put
the UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together to
make best use of the equipment.
The three themes of the proposal are imaging, informatics and stem cells.
For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processes
going on inside the brain that cause dementia can be studied.
For informatics we want to be bring together bas many different types of data as possible and make it easy as possible for
scientists to use them
For stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementias
process begins and progresses.
We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, making
the UK an internationally unique place to study dementia.
around 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways of
slowing it down. The platform has been funded to the level of £12M.
In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of the
opportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will put
the UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together to
make best use of the equipment.
The three themes of the proposal are imaging, informatics and stem cells.
For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processes
going on inside the brain that cause dementia can be studied.
For informatics we want to be bring together bas many different types of data as possible and make it easy as possible for
scientists to use them
For stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementias
process begins and progresses.
We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, making
the UK an internationally unique place to study dementia.
Technical Summary
Our objective is to achieve a step-change in UK dementia research capacity through establishing national networks of
existing and emerging centres of excellence in imaging, informatics and cell-biology.
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and
cost-effective translational pipeline from discovery through to early phase trials. UKDP will create closer synergy between
epidemiology and experimental medicine with the re-purposing of epidemiologic cohorts for trials readiness. The size and
depth of phenotyping available to UKDP will deliver a step-change in the complexity and granularity of dementia related
hypothesis testing and accelerate compound development.
Proposed here is an infrastructure of investment and collaboration. Underpinning UKDP is a critical mass of researchers
and resources that will work together to encourage, facilitate, and develop a fully integrated dementia dedicated UK
research environment. This will raise standards, reduce costs, and deliver innovative and coordinated research, to make
the UK an internationally unique research environment. Through its partnership with major academic centres and industry,
UKDP is well positioned to achieve this goal.
Building on the recent MRC investment in UKDP, we propose here to renew and extend the UKDP integrative research
environment with an advanced molecular imaging network strategically located to exploit UKDP cohorts. Also proposed is
an integrated informatics environment to facilitate the location of and access to both data and bio-samples. The third
proposal is for a stem-cells network to promote the use of this important and emerging technology. Each of these elements
adds value to existing infrastructure investments and fills significant gaps in the UK research landscape.
existing and emerging centres of excellence in imaging, informatics and cell-biology.
The UK Dementias Platform (UKDP) is a radically new approach to dementias research, providing a highly efficient and
cost-effective translational pipeline from discovery through to early phase trials. UKDP will create closer synergy between
epidemiology and experimental medicine with the re-purposing of epidemiologic cohorts for trials readiness. The size and
depth of phenotyping available to UKDP will deliver a step-change in the complexity and granularity of dementia related
hypothesis testing and accelerate compound development.
Proposed here is an infrastructure of investment and collaboration. Underpinning UKDP is a critical mass of researchers
and resources that will work together to encourage, facilitate, and develop a fully integrated dementia dedicated UK
research environment. This will raise standards, reduce costs, and deliver innovative and coordinated research, to make
the UK an internationally unique research environment. Through its partnership with major academic centres and industry,
UKDP is well positioned to achieve this goal.
Building on the recent MRC investment in UKDP, we propose here to renew and extend the UKDP integrative research
environment with an advanced molecular imaging network strategically located to exploit UKDP cohorts. Also proposed is
an integrated informatics environment to facilitate the location of and access to both data and bio-samples. The third
proposal is for a stem-cells network to promote the use of this important and emerging technology. Each of these elements
adds value to existing infrastructure investments and fills significant gaps in the UK research landscape.
Planned Impact
The current proposal in in support of the UKDP and will become part of the the UKDP impact strategy.
In summary, the UKDP strategy to deliver pact is to develop networks of partnership to actively consult engage the UK
academic community in relation to dementia research focussing on the direction,
technologies and collaborations of the UKDP and the wider UK national infrastructure.
Our aim is to:
1) promote the best possible science
2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
Partnership discussions with industry are already underway with exchanges of ides, interests and needs between
academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia
cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to
encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to
leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier
interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not
only to communicate our research findings and their relevance but also to address such issues as stigma in society and the
research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to
communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the
Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE
over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
In summary, the UKDP strategy to deliver pact is to develop networks of partnership to actively consult engage the UK
academic community in relation to dementia research focussing on the direction,
technologies and collaborations of the UKDP and the wider UK national infrastructure.
Our aim is to:
1) promote the best possible science
2) create momentum in dementias research by being inclusive of, and synergistic with, other initiatives.
Partnership discussions with industry are already underway with exchanges of ides, interests and needs between
academic and industry stakeholders. Industry have identified their need for access to conversion (early MVI to dementia
cohorts and for experimental medicine studies to conform to regulatory requirements.
We remain committed to raising the profile of contemporary debate about dementia and its treatment. We wish to
encourage a culture of commitment to solving this problem. By increasing awareness at all levels of society we intend to
leverage resources for the platform and for dementia research in general, to increase awareness of the need for earlier
interventions and better targeted treatment in general by health service providers and the public alike.
Engagement with the general public and with patients and carers is a very important part of our mission. This serves not
only to communicate our research findings and their relevance but also to address such issues as stigma in society and the
research culture in the NHS in relation to dementia and older people. In addition to using the platform web-site to
communicate to the general public, we will also liaise with charities and advocate groups such as Age UK and the
Alzheimer's Society to promote our work and findings and to engage them in shaping the work programme.
In addition we will have a dedicated free-phone number available 6 days a week and a communications officer at 50% FTE
over 5 years whose responsibility is to develop and implement a communications and public engagement strategy.
Organisations
- University of Oxford (Lead Research Organisation)
- MRC Dementias Platform UK (Collaboration)
- ASTON UNIVERSITY (Collaboration)
- ETH Zurich (Collaboration)
- Hospital and Greater Manchester Neuroscience Centre (Collaboration)
- University of Oslo (Collaboration)
- University of Southern Denmark (Collaboration)
- University of Bologna (Collaboration)
- AstraZeneca (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- National Institute on Aging (Collaboration)
- OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (Collaboration)
- Cardiff University (Collaboration)
- Bristol-Myers Squibb (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- University of Barcelona (Collaboration)
- University of Bristol (Collaboration)
- University of Manchester (Collaboration)
- University College London (Collaboration)
- University of Luxembourg (Collaboration)
- VU University Medical Center (Collaboration)
- McGill University (Collaboration)
- Newcastle University (Collaboration)
- UK Dementia Research Institute (Collaboration)
- Oxford Health NHS Foundation Trust (Collaboration)
- German Centre for Neurodegenerative Diseases (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Observational Health Data Sciences and Informatics (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- University of Göttingen (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Agarwal D
(2020)
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders.
in Nature communications
Allan CL
(2016)
Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort.
in Journal of affective disorders
Aman Y
(2020)
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases.
in International review of neurobiology
Anatürk M
(2020)
Associations Between Longitudinal Trajectories of Cognitive and Social Activities and Brain Health in Old Age.
in JAMA network open
Andreotti F
(2018)
Multichannel Sleep Stage Classification and Transfer Learning using Convolutional Neural Networks.
in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Arnaldi D
(2021)
Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder.
in Brain : a journal of neurology
Auger SD
(2020)
Testing Shortened Versions of Smell Tests to Screen for Hyposmia in Parkinson's Disease.
in Movement disorders clinical practice
Badanjak K
(2021)
iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease.
in Frontiers in cell and developmental biology
Baig F
(2020)
Reply to: "Predictors of motor complications in early Parkinson's disease".
in Movement disorders : official journal of the Movement Disorder Society
| Description | Kamina Naidoo is a mentor for the BiPOC Stem network THRIVE scheme |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to new or improved professional practice |
| URL | https://bipocstemnetwork.web.ox.ac.uk/ |
| Description | MRC Dementias Platform UK 'Open Science Champion' and Steering Group member |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| URL | http://www.mrc.ac.uk/research/facilities-and-resources-for-researchers/dementias-platform-uk/governa... |
| Description | UK Dementia Platform Executive Committee: Wade-Martins and Lovestone |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Launch of UK Dementia Platform; serve on Executive Committee |
| Description | ARUK Illustration Award 2021 given to Bryan Ng |
| Amount | £200 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2021 |
| End | 08/2021 |
| Description | ARUK Illustration Award 2023 given to Ajantha Abey |
| Amount | £200 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 05/2023 |
| Description | ARUK Illustration Award 2023 given to Rachel Heon Roberts |
| Amount | £200 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 05/2023 |
| Description | ARUK ODDI collaboration: Phenotypic drug discovery in Parkinson's |
| Amount | £200,000 (GBP) |
| Organisation | University of Oxford |
| Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2020 |
| Description | ARUK Oxford Pilot Investigating the effect of tau on axonal transport and tau release in MAPT-iPSC cortical neuron models |
| Amount | £4,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | ARUK Oxford Pilot Optogenetic light source and controller for 96/384-well plates to allow uniform illumination of wells inside a cell-culture incubator. |
| Amount | £4,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | ARUK Pilot Analysis of tau secretion in iPS differentiated neuronal cultures |
| Amount | £4,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | ARUK Pilot Award 2020-21 given to Dr Charmaine Lang & Mr Peter Kilfeather |
| Amount | £2,297 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 08/2021 |
| Description | ARUK Pilot Award 2020-21 given to Maria Claudia Caiazza |
| Amount | £2,500 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 08/2021 |
| Description | ARUK Thames Valley Network Pilot Award 2022 |
| Amount | £2,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 12/2023 |
| Description | ARUK Thames Valley Network Travel Award for Becky Carlyle |
| Amount | £168 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 12/2022 |
| Description | ARUK Thames Valley Network Travel Award for Brent Ryan to attend two conferences |
| Amount | £54,095 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 12/2022 |
| Description | ARUK Thames Valley Network Travel Award for Helle Barknob |
| Amount | £138 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 12/2022 |
| Description | ARUK Thames Valley Network Travel Award for Hugo Fernandes |
| Amount | £211 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 02/2023 |
| Description | ARUK Thames Valley Network Travel Award for Maria Claudia Caiazza |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2022 |
| Description | ARUK Thames Valley Network Travel Award for Rachel Heon Roberts |
| Amount | £600 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 01/2023 |
| Description | ARUK Thames Valley Network Travel Award for William McGuinness |
| Amount | £500 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 01/2023 |
| Description | ARUK Thames Valley Network travel award: Mootaz Salman |
| Amount | £600 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2023 |
| Description | ARUK Travel Award 2020-21 given to Kaitlyn Cramb to attend & present at AD/PD conference in Barcelona |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2022 |
| Description | ARUK Travel Award 2020-21 given to Martha Lavelle |
| Amount | £100 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 09/2021 |
| Description | ARUK Travel Award 2020-21 given to Quyen Do to attend Ion channels in Synaptic and Neural Circuit Physiology online conference |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2021 |
| End | 06/2021 |
| Description | ARUK Travel Award given to Ajantha Abey to attend ARUK Early Careers Day and Research Conference 2022 |
| Amount | £126 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2022 |
| End | 03/2022 |
| Description | ARUK Travel Award given to Ajantha Abey to attend ARUK Early Careers Day and Research Conference 2023 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to Akansha Mehta to attend ARUK Research Conference 2023 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to Bryan Ng to attend ARUK Early Careers Day and Research Conference 2022 |
| Amount | £205 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2022 |
| Description | ARUK Travel Award given to Charmaine Lang to attend ARUK Research Conference 2023 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to Gizem Onal to attend ARUK Research Conference 2023 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to Jonah-Wolf Schreier to attend ARUK Research Conference 2023 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to Kaitlyn Cramb to attend Federation of European Neuroscience Societies Regional Meeting 2023 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 05/2023 |
| Description | ARUK Travel Award given to Maria Claudia Caiazza to attend AD/PD conference 2022 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2022 |
| Description | ARUK Travel Award given to Maria Claudia Caiazza to attend Parkinson's Disease Theme ECR workshop Meeting 2023 |
| Amount | £204 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to Mootaz Salman to attend Brain 2022 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 07/2022 |
| Description | ARUK Travel Award given to Nancy Ahuja to attend ARUK Research Conference 2023 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to Naroa Ibarra Aizpurua to attend UKDRI - Parkinson's Disease Theme ECR Workshop 2023 |
| Amount | £96 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2023 |
| End | 03/2023 |
| Description | ARUK Travel Award given to William McGuinness to attend AD/PD conference 2022 |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 03/2022 |
| Description | Ajantha Abey, The Clarendon Fund & Department of Physiology, Anatomy, and Genetics Scholarship. Project title: Understanding Selective Neuronal Vulnerability in Alzheimer's and Parkinson's Disease and Potential Remedies Through Patient-Derived Stem-Cells |
| Amount | £125,097 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2023 |
| Description | Autophagic flux |
| Amount | £317,137 (GBP) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 08/2017 |
| End | 08/2019 |
| Description | Awarded an Oxford ARUK Small Equipment Award to purchase an Oxford Nanopore MinION |
| Amount | £3,670 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 07/2019 |
| Description | Becky Carlyle - Subcellular proteomic signatures of Alzheimer's disease. |
| Amount | $64,000 (USD) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 01/2022 |
| End | 12/2024 |
| Description | Cerebrovascular health in older adults at a genetic risk for dementia |
| Amount | £3,970 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 08/2018 |
| Description | Compartmentalised calcium handling in dopamine neurons: importance for selective vulnerability in Parkinson's. |
| Amount | £3,700,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 04/2027 |
| Description | Dept MRC Studentship (Principal Supervisor to Naroa Ibarra Aizpurua, Co-supervisor Dr Sally Cowley; Understanding the contribution of astrocytes to Parkinson's. |
| Amount | £15,900 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2022 |
| Description | Developing new therapeutic drugs in pre-clinical models of Parkinson's. |
| Amount | $200,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 06/2021 |
| End | 02/2023 |
| Description | Dr Andrea Loreto Sir Henry Wellcome postdoctoral fellowship. Project title: The role of the Wallerian axon-death pathway in neuronal and axonal vulnerability in Parkinson's disease |
| Amount | £250,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 04/2022 |
| Description | Dr Becky Carlyle: Exploiting sub-cellular proteomics and high-throughput validation screens to define the role of proteome complexity in Alzheimer's Disease |
| Amount | £420,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2025 |
| Description | Dr Charmaine Lang & Mr Peter Kilfeather were awarded an ARUK Thames Valley Pilot Award |
| Amount | £2,297 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 06/2021 |
| Description | Dr Mootaz Salman was awarded an ARUK Thames Valley Network Small Equipment Award 2020 |
| Amount | £2,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 03/2021 |
| Description | Dr Phillipa Carling was awarded an ARUK Thames Valley Network ECR award |
| Amount | £349 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 12/2020 |
| Description | Dr Stefania Giussani was awarded an ARUK Thames valley network ECR Award |
| Amount | £493 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 12/2020 |
| Description | ECR grant award for Bryan Ng |
| Amount | £425 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 03/2021 |
| Description | Elliot Mock - Validation of USP14 as a therapeutic target in Parkinson's disease. |
| Amount | £150,000 (GBP) |
| Organisation | Netherlands Organisation for Scientific Research (NWO) |
| Sector | Public |
| Country | Netherlands |
| Start | 09/2021 |
| End | 09/2023 |
| Description | Enhancing autophagic flux in Parkinson's disease |
| Amount | $663,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 09/2017 |
| End | 09/2019 |
| Description | FENS travel award for Bryan Ng |
| Amount | € 75 (EUR) |
| Organisation | Federation of European Neuroscience Societies (FENS) |
| Sector | Private |
| Country | Belgium |
| Start | 06/2020 |
| End | 07/2020 |
| Description | Functional screening of Parkinson's GWAS loci in human iPSC neurons |
| Amount | £1,400,000 (GBP) |
| Organisation | GlaxoSmithKline (GSK) |
| Sector | Private |
| Country | Global |
| Start | 12/2020 |
| End | 06/2024 |
| Description | High content imaging of iPSC-derived neurons to dissect mechanisms of Parkinson's |
| Amount | £80,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 09/2021 |
| Description | Interrogation of the STING pathway in iPS cell models of Parkinson's. SA Cowley |
| Amount | $289,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 04/2022 |
| End | 04/2024 |
| Description | Iona Thomas Wright : Departmental Neuroscience DPhil Studentship Understanding the mechanisms of pathological alpha-synuclein cell-to-cell transfer |
| Amount | £75,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2026 |
| Description | JPND |
| Amount | £350,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 05/2019 |
| Description | Johanna Hoffman - Understanding organellar calcium signalling in Parkinson's iPSC-dopamine neurons |
| Amount | £100,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2026 |
| Description | MJ Fox Therapeutic Pipeline Program: Enhancing autophagy flux in Parkinson's disease |
| Amount | $330,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | |
| Description | MRC COEN |
| Amount | £150,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 06/2018 |
| Description | MRC Momentum Award (Microglial interactions in Alzheimer's Disease) |
| Amount | £4,300,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2017 |
| Description | MRC Momentum Award (Microglial interactions in Alzheimer's Disease-informatics) |
| Amount | £1,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Partnership Award (Dementias Platform UK Stem Cell Partnership) |
| Amount | £1,200,000 (GBP) |
| Funding ID | MR/N013255/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2016 |
| End | 06/2020 |
| Description | MRC Project Grant MR/V013599: Identifying the regulation of striatal dopamine function by striatal astrocytes in health and parkinsonism (Prof S Cragg & Prof R Wade-Martins) |
| Amount | £1,038,078 (GBP) |
| Funding ID | MR/V013599 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 01/2024 |
| Description | Mapping the Modulatory Landscape Governing Striatal Dopamine Signaling and Its Dysregulation in Parkinson's Disease. |
| Amount | $9,000,000 (USD) |
| Organisation | Aligning Sciences Across Parkinson's |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 11/2021 |
| End | 10/2024 |
| Description | Maria Claudia Caiazza was awarded an ARUK Thames Valley network Pilot Award |
| Amount | £2,500 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 06/2021 |
| Description | Mental Health Pathfinder Award |
| Amount | £1,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Michael J Fox Foundation: In depth phenotypic profiling of PINK1/Parkin stem cell-derived neurons and glia.(Prof Wade-Martins) |
| Amount | $600,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 08/2021 |
| End | 02/2023 |
| Description | Michael J Fox Foundation: Transcriptomic changes in iPSC-derived dopaminergic neurons induced by exposure to alpha-synuclein revealed by single cell RNA-Seq. |
| Amount | $200,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2021 |
| End | 09/2022 |
| Description | Michael J Fox Foundation: Validation of FASN as a target for therapeutic development in PD.(Prof Wade-Martins) |
| Amount | $200,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 03/2021 |
| End | 11/2022 |
| Description | Mootaz Salman - Organ-on-a-chip human patient stem cell models of the blood-barrier in Parkinson's disease. |
| Amount | £115,000 (GBP) |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2022 |
| End | 04/2025 |
| Description | NIHR Oxford Health Biomedical Research Centre |
| Amount | £12,800,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | NIHR Oxford Health Clinical Research Facility |
| Amount | £65,686 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Oxford Biomedical Research Centre (BRC) |
| Amount | £45,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Oxford Medical Sciences Divisions Returning Carer Fund (Tara Caffrey) |
| Amount | £5,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 05/2017 |
| Description | Peter Kilfeather awarded funding to study using spatial transcriptomics to look at SNpc and VTA gene expression on wild-type mice compared to SNCA-OVX mice. |
| Amount | £22,151 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2021 |
| End | 12/2021 |
| Description | Rachel Heon-Roberts, Clarendon Fund & Dept of Physiology, Anatomy, & Genetics. Project title: Establishing a model of a-synuclein and amyloid-ß-induced mitochondrial & lysosomal dysfunction in Alzheimer's disease, PD & Lewy Body dementias |
| Amount | £105,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2024 |
| Description | Sanofi/Genzyme: Modulating GBA activity as a Parkinson's disease therapy |
| Amount | £200,000 (GBP) |
| Organisation | Sanofi |
| Department | Genzyme Therapeutics Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 10/2017 |
| Description | Stefania Guisanni was successful with an ARUK ECR video awards |
| Amount | £320 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 12/2021 |
| Description | Targeting lysosomes to enhance autophagy in Parkinson's |
| Amount | £350,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 08/2020 |
| Description | The UKDRI IPSC Platform to Model Alzheimer's Disease Risk (IPMAR). SA Cowley |
| Amount | £1,770,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 12/2023 |
| Description | Transcriptomic changes in iPSC-derived dopaminergic neurons induced by exposure to alpha-synuclein revealed by single cell RNA-Seq. |
| Amount | $200,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 06/2021 |
| End | 02/2023 |
| Description | Travel grant for conference for Bryan Ng |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2020 |
| Description | Travel grant for conference for Bryan Ng |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2019 |
| Description | Travel grant for conference for Bryan Ng |
| Amount | £300 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2020 |
| Description | Understanding vulnerability and resistance in Alzheimer's disease |
| Amount | £99,428 (GBP) |
| Organisation | Janssen Biotech, Inc. |
| Sector | Private |
| Country | United States |
| Start | 03/2023 |
| End | 03/2024 |
| Description | Uniting iPSCS and CRISPR/Cas9 screens- a platform to model and interrogate genetic disease in Oxford |
| Amount | £80,000 (GBP) |
| Organisation | University of Edinburgh |
| Department | Institutional Strategic Support Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2017 |
| End | 06/2019 |
| Description | Wellcome Institutional Strategic Support Fund (Prof Clare Mackay) |
| Amount | £89,600 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2022 |
| Description | Wellcome Institutional Strategic Support Fund: Wellcome Trust Centre for Integrative Neuroimaging |
| Amount | £100,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Integrative Neuroimaging Seed funding - £12,000 . Natalie Connor-Robson |
| Amount | £12,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust Centre for Integrative Neuroimaging |
| Amount | £12,500,000 (GBP) |
| Funding ID | 203139/Z/16/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Wellcome Trust DPhil Studentship in Neuroscience: Characterisation of a novel GBA-L444P BAC transgenic mouse model of Parkinson's. (Supervisor to Tara Diviney, Co-Supervisor Prof Stephanie Cragg |
| Amount | £104,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2023 |
| Description | What makes strategic stroke strategic? Multimodal imaging and network methods to predict dementia after strategic stroke |
| Amount | £4,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 08/2017 |
| Title | CRISPR gene editing |
| Description | We have been able to establish CRISPR/Cas9 gene editing in our lab as a result of this project |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | We have been able to perform gene editing in iPSC lines. |
| Title | Dopamine neuron microfluidics |
| Description | Development of stem cell-derived neuronal culture techniques using microfluidic devices to channel axonal growth. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Provided To Others? | No |
| Impact | Not yet: it is ongoing development |
| Title | Generation of MAPT CRISPR gene edited iPSC lines |
| Description | We have generated 8 QCed MAPT-/- knockout lines on 2 control backgrounds. |
| Type Of Material | Cell line |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | We will use the MAPT-/- iPSC-derived neurons to study the role of MAPT in Parkinson's |
| Title | Generation of SNCA CRISPR gene edited iPSC lines |
| Description | We have generated 3 QCed SNCA-/- knockout lines on control background and isogenic correction of SNCA Triplication patient line (and also knockout) - clones identified by droplet digital PCR, undergoing confirmatory sequencing. |
| Type Of Material | Cell line |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Generation of SNCA CRISPR gene edited lines will further our work on the role of macrophages and microglia on the uptake/processing/secretion of alpha-synuclein and its role in stimulating the immune response and enable us to interrogate the mechanism for the phagocytosis defect phenotype observed in the SNCA-Triplication macrophages/microglia. |
| Title | High content, high throughput analysis |
| Description | The ability to perform detailed high-throughput analysis of neurons in culture |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Shared use of best practice in high-throughput analysis using Opera Phenix imager and high-throughout plate readers |
| Title | In vitro electrophysiology |
| Description | Patch-clamp techniques to measure neuronal activity of stem cell-derived neurons |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Analaysis of stem cell-derived neurons: dopamine neurons, cortical neurons, motor neurons and medium spiny neurons |
| Title | Live cell imaging techniques in iPS-derived DA neurons in vitro |
| Description | We have optimised a live cell imaging protocol for the visualisation and measurement of mitochondrial membrane potential in differentiated neurons. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | The membrane potential-sensing dye TMRM can be used to quantify membrane potential, with increased fluorescence indicating increased membrane potential. |
| Title | Microglia differentiation |
| Description | The ability to generate microglia from human stem cells from dementia patients |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | We will be able to compare the function of microglia generated from patients and from controls |
| Title | PLA in stem cell neurons |
| Description | To enable the detection of a-syn oligomers in stem cell-derived dopamine neurons |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | The detection of a-syn oligomers in stem cell-derived dopamine neurons |
| Title | RNA-Seq |
| Description | Development of methods for analysis of RNA-Seq |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Understanding of gene expression profiles in selected cell population |
| Title | Target discovery assays |
| Description | Develop target discovery assays using high throughput screens |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | New research facilty built for our work |
| Title | iPSC phenotypic screens |
| Description | We have developed an organelle calcium flux assay for high-throughput screening and applied the assay to screen 4000 small molecules in Parkinson's patient iPSC-dervied dopamine neurons. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | We will use the assay to identify new therapeutic targets or novel and or repurposable small molecule therapeutics. |
| Title | Imaging Informatics Infrastructure for the dementias platform UK |
| Description | We have built a federated data sharing platform for imaging data relevant to DPUK using XNAT |
| Type Of Material | Data handling & control |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| Impact | Infrastructure being used by the MRC UK7T partnership, UK 7T network and by the MRC/NIHR Deep & Frequent Phenotyping study, as well as hosting a growing amount of existing cohort imaging data. |
| URL | https://info.dpuk.org/ |
| Title | Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function |
| Description | The accumulation of toxic protein aggregates in multiple neurodegenerative diseases is associated with defects in the macroautophagy/autophagy-lysosome pathway. The amelioration of disease phenotypes across multiple models of neurodegeneration can be achieved through modulating the master regulator of lysosome function, TFEB (transcription factor EB). Using a novel multi-parameter high-throughput screen for cytoplasmic:nuclear translocation of endogenous TFEB and the related transcription factor TFE3, we screened the Published Kinase Inhibitor Set 2 (PKIS2) library as proof of principle and to identify kinase regulators of TFEB and TFE3. Given that TFEB and TFE3 are responsive to cellular stress we have established assays for cellular toxicity and lysosomal function, critical to ensuring the identification of hit compounds with only positive effects on lysosome activity. In addition to AKT inhibitors which regulate TFEB localization, we identified a series of quinazoline-derivative compounds that induced TFEB and TFE3 translocation. A novel series of structurally-related analogs was developed, and several compounds induced TFEB and TFE3 translocation at higher potency than previously screened compounds. KINOMEscan and cell-based KiNativ kinase profiling revealed high binding for the PRKD (protein kinase D) family of kinases, suggesting good selectivity for these compounds. We describe and utilize a cellular target-validation platform using CRISPRi knockdown and orthogonal PRKD inhibitors to demonstrate that the activity of these compounds is independent of PRKD inhibition. The more potent analogs induced subsequent upregulation of the CLEAR gene network and cleared pathological HTT protein in a cellular model of proteinopathy, demonstrating their potential to alleviate neurodegeneration-relevant phenotypes. Abbreviations: AD: Alzheimer disease; AK: adenylate kinase; CLEAR: coordinated lysosomal expression and regulation; CQ: chloroquine; HD: Huntington disease; PD: Parkinson disease; PKIS2: Published Kinase Inhibitor Set 2; PRKD: protein kinase D; TFEB: transcription factor EB. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://tandf.figshare.com/articles/dataset/Multiparameter_phenotypic_screening_for_endogenous_TFEB_... |
| Title | Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function |
| Description | The accumulation of toxic protein aggregates in multiple neurodegenerative diseases is associated with defects in the macroautophagy/autophagy-lysosome pathway. The amelioration of disease phenotypes across multiple models of neurodegeneration can be achieved through modulating the master regulator of lysosome function, TFEB (transcription factor EB). Using a novel multi-parameter high-throughput screen for cytoplasmic:nuclear translocation of endogenous TFEB and the related transcription factor TFE3, we screened the Published Kinase Inhibitor Set 2 (PKIS2) library as proof of principle and to identify kinase regulators of TFEB and TFE3. Given that TFEB and TFE3 are responsive to cellular stress we have established assays for cellular toxicity and lysosomal function, critical to ensuring the identification of hit compounds with only positive effects on lysosome activity. In addition to AKT inhibitors which regulate TFEB localization, we identified a series of quinazoline-derivative compounds that induced TFEB and TFE3 translocation. A novel series of structurally-related analogs was developed, and several compounds induced TFEB and TFE3 translocation at higher potency than previously screened compounds. KINOMEscan and cell-based KiNativ kinase profiling revealed high binding for the PRKD (protein kinase D) family of kinases, suggesting good selectivity for these compounds. We describe and utilize a cellular target-validation platform using CRISPRi knockdown and orthogonal PRKD inhibitors to demonstrate that the activity of these compounds is independent of PRKD inhibition. The more potent analogs induced subsequent upregulation of the CLEAR gene network and cleared pathological HTT protein in a cellular model of proteinopathy, demonstrating their potential to alleviate neurodegeneration-relevant phenotypes. Abbreviations: AD: Alzheimer disease; AK: adenylate kinase; CLEAR: coordinated lysosomal expression and regulation; CQ: chloroquine; HD: Huntington disease; PD: Parkinson disease; PKIS2: Published Kinase Inhibitor Set 2; PRKD: protein kinase D; TFEB: transcription factor EB. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://tandf.figshare.com/articles/dataset/Multiparameter_phenotypic_screening_for_endogenous_TFEB_... |
| Description | Abeta functional assays |
| Organisation | University of Oxford |
| Department | Department of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have worked to develop improved in vitro analysis odf Abeta function |
| Collaborator Contribution | Collaborative development of assay |
| Impact | Ongoing collaboration |
| Start Year | 2015 |
| Description | Ajantha Abey in collaboration with Margarida Ruas' lab, University of Oxford |
| Organisation | University of Oxford |
| Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | I have provided dopaminergic and cortical neuronal precursors and conducted differentiations into mature neurons with the genetic constructs. I also performed live imaging on the Opera Phenix and fixed and stained cells after growing them for validation. Also provided training on how to differentiate iPSC neurons. |
| Collaborator Contribution | Partners provided lentiviral constructs for assaying lysosomal pH, as well as assistance on planning and designing experiments and interpreting preliminary results. |
| Impact | n/a |
| Start Year | 2023 |
| Description | DPUK Cambridge |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Optimisation of high-content imaging protocols with Opera Phenix imager |
| Collaborator Contribution | The ARUK Stem Cell Research Centre, Cambridge has standardised the use of the Opera Phenix and Nanostring Sprint instruments for QC in iPSC reprogramming and cproduction of cortical neurons. The Phenix is used for high-throughput imaging of pluripotency markers in patient-derived lines that are generated at the centre. The lab has established a method for routine characterisation of cortical neuron productions using the Nanostring digital gene expression platform. This will facilitate harmonisation of protocols between DPUK centres, and within the STEMBANCC consortium. The imaging platform has been used to develop methods for production of human microglia from iPSCs, and to study cell biology in patient iPSC-derived microglia, focussing on TREM2 mutatiosn. In collaboration with Talisman Therapeutics and AstraZeneca, assays have been established to measure protein uptake in cortical neurons by live imaging. |
| Impact | Development of a strong Dementia Stem Cell Network in DPUK |
| Start Year | 2016 |
| Description | DPUK DSCN |
| Organisation | Cardiff University |
| Department | School of Biosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University College London |
| Department | Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Cambridge |
| Department | Gurdon Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Edinburgh |
| Department | MRC Centre for Regenerative Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK DSCN |
| Organisation | University of Manchester |
| Department | Manchester Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Forming DPUK Dementia Stem Cell Network |
| Collaborator Contribution | Forming DPUK Dementia Stem Cell Network |
| Impact | Collaborations and interactions |
| Start Year | 2015 |
| Description | DPUK Data Discovery Tools Categorisation and Coding Programme |
| Organisation | University of Oxford |
| Department | Department of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provide data from our cohort |
| Collaborator Contribution | Create Data discovery tool |
| Impact | Still ongoing |
| Start Year | 2018 |
| Description | Dementias Platform UK Stem Cell Partnership |
| Organisation | MRC Dementias Platform UK |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Collaborator Contribution | Members will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Impact | Ongoing |
| Start Year | 2016 |
| Description | Dementias Platform UK Stem Cell Partnership |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | OPDC will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Collaborator Contribution | Members will share expertise and stem cell lines as part of DPUK Stem Cell Network |
| Impact | Ongoing |
| Start Year | 2016 |
| Description | Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease |
| Organisation | McGill University |
| Department | Montreal Neurological Institute and Hospital |
| Country | Canada |
| Sector | Hospitals |
| PI Contribution | Laura Parkkinen and team will analyze CSF samples |
| Collaborator Contribution | Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients. |
| Impact | We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019 |
| Start Year | 2018 |
| Description | Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | Laura Parkkinen and team will analyze CSF samples |
| Collaborator Contribution | Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients. |
| Impact | We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019 |
| Start Year | 2018 |
| Description | Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease |
| Organisation | University of Barcelona |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Laura Parkkinen and team will analyze CSF samples |
| Collaborator Contribution | Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients. |
| Impact | We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019 |
| Start Year | 2018 |
| Description | Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease |
| Organisation | University of Bologna |
| Department | Department of Neurologial Sciences |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Laura Parkkinen and team will analyze CSF samples |
| Collaborator Contribution | Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients. |
| Impact | We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019 |
| Start Year | 2018 |
| Description | Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease |
| Organisation | University of Göttingen |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Laura Parkkinen and team will analyze CSF samples |
| Collaborator Contribution | Dr Brit Mollenhauer (University of Gottingen); Dr Alex Iranzo (University of Barcelona); Dr Bradley Boeve, (NIH); Dr Ronald Postuma (McGill University); Dr Elena Antelmi (University of Bologna) who all provide us with CSF samples from longitudinally followed RBD patients. |
| Impact | We have received a 2-year project grant entitled "Development of alpha-synuclein seeding assay as an early, progression and stratifying biomarker for Parkinson's disease" from PD UK starting from 1st February 2019 |
| Start Year | 2018 |
| Description | Dr Ben Vallin with Prof Caleb Webber |
| Organisation | UK Dementia Research Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | The project I am working on is a collaborative work with the group of Caleb Webber in Cardiff. This collaboration started on September 2021, is still active, and was funded by the Michael J. Fox Foundation (grant application ID: MJFF-019042; total requested amount: $199,507.80). Our contribution: we designed a cellular model of ?-synuclein propagation composed of dopaminergic neurons derived from healthy control iPSCs co-cultured with dopaminergic neurons derived from Parkinson's disease (PD) iPSCs harbouring a triplication of the ?-synuclein locus. I performed the cell culture, isolated the viable dopaminergic neurons and provided them to the group of Caleb Webber for single cell RNA-sequencing. |
| Collaborator Contribution | Caleb Webber's team separated the cell samples we provided into single cells, generated the corresponding cDNA libraries, and performed single cell RNA-sequencing and bioinformatic analysis. |
| Impact | n/a |
| Start Year | 2021 |
| Description | Dr Brent Ryan & Derek Narendra NIH Inherited Movement Disorders Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD |
| Organisation | National Institutes of Health (NIH) |
| Department | National Institute of Neurological Disorders and Stroke (NINDS) |
| Country | United States |
| Sector | Public |
| PI Contribution | Dr Brent Ryan & Derek Narendra NIH Inherited Movement Disorders Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD. Scope: Collaboration to assess mitophagy in models of PD |
| Collaborator Contribution | Dr Brent Ryan & Derek Narendra NIH Inherited Movement Disorders Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD. Scope: Collaboration to assess mitophagy in models of PD Publication: Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ. Trends Biochem Sci. 2020 Dec 12:S0968-0004(20)30278-4. doi: 10.1016/j.tibs.2020.11.007. Online ahead of print. PMID: 33323315 |
| Impact | Publication: Malpartida AB, Williamson M, Narendra DP, Wade-Martins R, Ryan BJ. Trends Biochem Sci. 2020 Dec 12:S0968-0004(20)30278-4. doi: 10.1016/j.tibs.2020.11.007. Online ahead of print. PMID: 33323315 |
| Start Year | 2020 |
| Description | Dr Brent Ryan & Dr Elena Britti in collaboration with Dr Katherine England |
| Organisation | University of Oxford |
| Department | Nuffield Department of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Brent Ryan and Dr Elena Britti are working with Dr Katherine England with her ARUK Pilot Award. Title of project: Enhancing the cellular permeability of live cell protein aggregation probes |
| Collaborator Contribution | Dr Brent Ryan and Dr Elena Britti are working with Dr Katherine England with her ARUK Pilot Award. Title of project: Enhancing the cellular permeability of live cell protein aggregation probes |
| Impact | n/a |
| Start Year | 2022 |
| Description | Dr Brent Ryan & Evandro Fang University of Oslo, Norway Scope: Assessment of mitophagy modulators in iPSC models of PD |
| Organisation | University of Oslo |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Dr Brent Ryan collaborating with Evandro Fang University of Oslo, Norway Scope: Assessment of mitophagy modulators in iPSC models of PD Output: Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF. Int Rev Neurobiol. 2020;155:169-202. doi: 10.1016/bs.irn.2020.02.008. Epub 2020 Aug 11. PMID: 32854854 |
| Collaborator Contribution | Dr Brent Ryan collaborating with Evandro Fang University of Oslo, Norway Scope: Assessment of mitophagy modulators in iPSC models of PD Output: Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF. Int Rev Neurobiol. 2020;155:169-202. doi: 10.1016/bs.irn.2020.02.008. Epub 2020 Aug 11. PMID: 32854854 |
| Impact | Publication: Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF. Int Rev Neurobiol. 2020;155:169-202. doi: 10.1016/bs.irn.2020.02.008. Epub 2020 Aug 11. PMID: 32854854 |
| Start Year | 2020 |
| Description | Dr Brent Ryan collaboration with Dr Maria Letizia Lo Faro NDSS |
| Organisation | University of Oxford |
| Department | Nuffield Department of Surgical Sciences Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Dr Maria Letizia Lo Faro (NDSS) to investigate the role of mitophagy in models of organ transplantation initiated in 2022. Grants pending. |
| Collaborator Contribution | Collaboration with Dr Maria Letizia Lo Faro (NDSS) to investigate the role of mitophagy in models of organ transplantation initiated in 2022. Grants pending. |
| Impact | Collaboration with Dr Maria Letizia Lo Faro (NDSS) to investigate the role of mitophagy in models of organ transplantation initiated in 2022. Grants pending. |
| Start Year | 2022 |
| Description | Dr Brent Ryan collaboration with Dr Mark Cookson |
| Organisation | National Institute on Aging |
| Department | Laboratory of Neurogenetics |
| Country | United States |
| Sector | Public |
| PI Contribution | Collaboration with Dr Mark Cookson (National Institute on Aging, USA) initiated in 2022 to share proteomics datasets from patient iPSC-derived cell types including dopaminergic neurons and microglia. Not governed by formal agreements (grants pending). |
| Collaborator Contribution | Collaboration with Dr Mark Cookson (National Institute on Aging, USA) initiated in 2022 to share proteomics datasets from patient iPSC-derived cell types including dopaminergic neurons and microglia. Not governed by formal agreements (grants pending). |
| Impact | n/a |
| Start Year | 2022 |
| Description | Dr Brent Ryan collaboration with Dr Morten Meyer (University of Southern Denmark). |
| Organisation | University of Southern Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Collaboration with Dr Morten Meyer (University of Southern Denmark). Investigation of RhoA signalling in Parkinson's- student Sissel Ida Schmidt is visiting for 6 months. Publication Okarmus et al 2021. |
| Collaborator Contribution | Investigation of RhoA signalling in Parkinson's- student Sissel Ida Schmidt is visiting for 6 months. Publication Okarmus et al 2021. |
| Impact | Justyna Okarmus, Jesper F. Havelund, Matias Ryding, Sissel I. Schmidt, Helle Bogetofte, Rachel Heon-Roberts, Richard Wade-Martins, Sally A. Cowley, Brent J. Ryan, Nils J. Færgeman, Poul Hyttel, Morten Meyer, Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism, Stem Cell Reports, Volume 16, Issue 6, 2021, Pages 1510-1526, ISSN 2213-6711, https://doi.org/10.1016/j.stemcr.2021.04.022. (https://www.sciencedirect.com/science/article/pii/S2213671121002174) Abstract: Summary PARK2 (parkin) mutations cause early-onset Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that participates in several cellular functions, including mitochondrial homeostasis. However, the specific metabolomic changes caused by parkin depletion remain unknown. Here, we used isogenic human induced pluripotent stem cells (iPSCs) with and without PARK2 knockout (KO) to investigate the effect of parkin loss of function by comparative metabolomics supplemented with ultrastructural and functional analyses. PARK2 KO neurons displayed increased tricarboxylic acid (TCA) cycle activity, perturbed mitochondrial ultrastructure, ATP depletion, and dysregulation of glycolysis and carnitine metabolism. These perturbations were combined with increased oxidative stress and a decreased anti-oxidative response. Key findings for PARK2 KO cells were confirmed using patient-specific iPSC-derived neurons. Overall, our data describe a unique metabolomic profile associated with parkin dysfunction and show that combining metabolomics with an iPSC-derived dopaminergic neuronal model of PD is a valuable approach to obtain novel insight into the disease pathogenesis. Keywords: Parkinson's disease; parkin; induced pluripotent stem cells; metabolomics; mitochondria; oxidative stress |
| Start Year | 2021 |
| Description | Dr Brent Ryan collaboration with Prof. Martin Rossel Larsen & Dr Helle Bogetofte (University of Southern Denmark) |
| Organisation | University of Southern Denmark |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Collaboration with Prof. Martin Rossel Larsen & Dr Helle Bogetofte (University of Southern Denmark) to perform post-translational proteomics on iPSC-derived neurons generated in Oxford. Not governed by formal agreements (grants pending). |
| Collaborator Contribution | Continuing collaboration with Prof. Martin Rossel Larsen & Dr Helle Bogetofte (University of Southern Denmark) to perform post-translational proteomics on iPSC-derived neurons generated in Oxford. Not governed by formal agreements (grants pending). |
| Impact | n/a |
| Start Year | 2021 |
| Description | Dr Mootaz Salman collaboration the University of Glasgow & Aston University |
| Organisation | Aston University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The Chief Scientist Office of the Government of Scotland has awarded a collaborative grant of £298,966 to Dr Mootaz Salman to seek new therapeutic avenues to treat stroke. Dr Mootaz Salman will collaborate with principal investigator Dr Lorraine Work from the University of Glasgow, together with Professor Roslyn Bill and Dr Stuart Greenhill from Aston University. Over a two-year project, the research team will establish whether the combined targeting of oedema (brain swelling) and neuronal plasticity (the capacity of the nervous system to modify itself) can be used as a new therapeutic framework to treat stroke. This new research objective will expand the translation of a drug candidate that has been described in their groundbreaking research published in the journal Cell in 2020 and a follow-up paper in BBA-Biomembranes in 2021, where Dr Mootaz Salman was both the co-first and corresponding author. In their 2021 paper, the team demonstrated compelling evidence that the drug - the FDA-approved antipsychotic medication known as trifluoperazine (TFP) - has the potential to stop the swelling in the brain that occurs after a stroke or other cerebral injury. |
| Collaborator Contribution | n/a |
| Impact | n/a |
| Start Year | 2023 |
| Description | Dr Mootaz Salman collaboration the University of Glasgow & Aston University |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The Chief Scientist Office of the Government of Scotland has awarded a collaborative grant of £298,966 to Dr Mootaz Salman to seek new therapeutic avenues to treat stroke. Dr Mootaz Salman will collaborate with principal investigator Dr Lorraine Work from the University of Glasgow, together with Professor Roslyn Bill and Dr Stuart Greenhill from Aston University. Over a two-year project, the research team will establish whether the combined targeting of oedema (brain swelling) and neuronal plasticity (the capacity of the nervous system to modify itself) can be used as a new therapeutic framework to treat stroke. This new research objective will expand the translation of a drug candidate that has been described in their groundbreaking research published in the journal Cell in 2020 and a follow-up paper in BBA-Biomembranes in 2021, where Dr Mootaz Salman was both the co-first and corresponding author. In their 2021 paper, the team demonstrated compelling evidence that the drug - the FDA-approved antipsychotic medication known as trifluoperazine (TFP) - has the potential to stop the swelling in the brain that occurs after a stroke or other cerebral injury. |
| Collaborator Contribution | n/a |
| Impact | n/a |
| Start Year | 2023 |
| Description | ETH Zurich - Oxford collaboration for functional imaging in a rodent model of Parkinson's disease |
| Organisation | ETH Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Richard Wade-Martin's lab has engineered the rodent model of Parkinson's disease (human SCA overexpression). This model has been characterized with histology, voltammetry of dopamine release in cell culture, and behaviourally. In collaboration with the Zurich group, Johannes Klein has performed data analysis on the imaging provided by ETH Zurich. |
| Collaborator Contribution | Oxford does not currently have the ability to perform high-quality resting state MRI in small animals. Our collaboration partners at ETH of acquired the imaging data, performed pre-processing with motion correction and ICA data cleaning. Together, we have analysed differences in brain networks between mice overexpressing human alpha-synuclein, and alpha-synuclein knockout siblings. |
| Impact | The research is ongoing. The imaging data will be published in the coming year. |
| Start Year | 2015 |
| Description | Electrophysiology in iPSC neurons |
| Organisation | University of Oxford |
| Department | Department of Pharmacology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have worked to establish electrophysiology analysis of iPSC-derived cortical neurons |
| Collaborator Contribution | Helped us to establish the technique |
| Impact | Ongoing collaboration |
| Start Year | 2014 |
| Description | Enhancing autophagy flux in Parkinson's disease |
| Organisation | AstraZeneca |
| Department | Astra Zeneca |
| Country | United States |
| Sector | Private |
| PI Contribution | OPDC test drug like molecules in cellular models of Parkinson's |
| Collaborator Contribution | Astra Zeneca to provide drug-like small molecules. |
| Impact | Ongoing |
| Start Year | 2016 |
| Description | Established collaboration with Ira Milosevic, University of Oxford Wellcome Centre for Human Genetics |
| Organisation | University of Oxford |
| Department | Wellcome Trust Centre for Human Genetics |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | To study synaptic vesicle recycling and STXBP6 biology in our Parkinson's models. Ira will provide the tools and expertise. |
| Collaborator Contribution | The collaboration will be to study synaptic vesicle recycling and STXBP6 biology in our Parkinson's models. Ira will provide tools and expertise |
| Impact | The collaboration will be to study synaptic vesicle recycling and STXBP6 biology in our Parkinson's models. Ira will provide tools and expertise |
| Start Year | 2021 |
| Description | Evaluation of selected CSF proteins as prognostic markers of dementia in patients with Parkinson's disease |
| Organisation | Oxford University Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of samples from our cohort |
| Collaborator Contribution | Measuring two serum proteins (haptoglobin and homocysteine), as well as two cerebrospinal fluid proteins (Aß1-42 and phospho-tau). |
| Impact | Ongoing research |
| Start Year | 2016 |
| Description | Free living walking behaviour in a cohort of people with RBD |
| Organisation | Newcastle University |
| Department | Institute of Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | applying the Axivity Device to RBD and Control participants attending Discovery clinic and providing clinical data |
| Collaborator Contribution | Further analysis of data to look for evidence of the onset of motor-symptoms. |
| Impact | Ongoing research |
| Start Year | 2016 |
| Description | Lysosomal dysfunction and glycosphingolipid dysregulation in Parkinson's |
| Organisation | University of Oxford |
| Department | Department of Pharmacology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have provided serum samples from our cohort |
| Collaborator Contribution | analyse serum/plasma and CSF from PD patients, at--risk patients and control cases as our aims are to characterise the pattern of expression of GSLs in PD and to search for lipid biomarkers |
| Impact | Ongoing research |
| Start Year | 2016 |
| Description | Neurochip Task Force Genetics Study |
| Organisation | German Centre for Neurodegenerative Diseases |
| Country | Germany |
| Sector | Public |
| PI Contribution | All study members to genotype their cohort on same chip |
| Collaborator Contribution | Sharing genomic data between cohorts with OPDC and Centre PD |
| Impact | Still active |
| Start Year | 2018 |
| Description | Neurochip Task Force Genetics Study |
| Organisation | University of Luxembourg |
| Department | Faculty of Science, Technology and Communication |
| Country | Luxembourg |
| Sector | Academic/University |
| PI Contribution | All study members to genotype their cohort on same chip |
| Collaborator Contribution | Sharing genomic data between cohorts with OPDC and Centre PD |
| Impact | Still active |
| Start Year | 2018 |
| Description | ODDI Phenotypic drug discovery in Parkinson's |
| Organisation | University of Oxford |
| Department | Alzheimer's Research UK Oxford Drug Discovery Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Collaborative drug discovery project in Parkinson's |
| Collaborator Contribution | Collaborative drug discovery project in Parkinson's |
| Impact | Ongoing |
| Start Year | 2017 |
| Description | Oxford collaboration for molecular imaging (PET) in a rodent model of Parkinson's disease. |
| Organisation | University of Oxford |
| Department | Department of Oncology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Richard Wade-Martins' lab has engineered rodent models of Parkinson's disease: LRRK2 BAC transgenic rats expressing human wild-type, G2019S, or R1441C LRRK2 mutations. These models have been extensively characterised using behavioural tests, voltammetry, electrophysiological recordings and immunohistochemistry analyses, showing that transgenic rats aged 18-21 months bearing any of the LRRK2 mutations exhibit L-DOPA responsive motor dysfunction, impaired striatal dopamine release, and cognitive deficits, but with no apparent neurodegeneration or protein accumulation on histology. In collaboration with the Imaging Core at the Oncology Department, we have optimised a scanning protocol for the aged rat-cohorts that will allow the acquisition of 18F-DOPA PET data to further characterise the effect of these mutations on dopamine metabolism, and validate these rodent models for future imaging studies. The aim is to provide early imaging readouts for the response to therapy with candidate compounds in an animal model of the early stages of PD. |
| Collaborator Contribution | This collaboration allows us to bring new methods to OPDC. Our collaborators provide the radiotracers needed to perform our molecular imaging studies (fluorodopa is not routinely produced or distributed), and the facilities and expertise to run our scans. Veronique Gouverneur's lab has pioneered a new synthesis route for fluorodopa, and they are currently working to scale it up to production level for us. Sean Smart and Veerle Kersemans run the PET facility at the Oncology Department and have optimised the imaging logistics, and helped with acquisition protocols and data reconstruction so we are able to scan our aging cohorts in time. |
| Impact | Initial pilot studies have been performed to detect and address imaging-specific problems before starting the analysis of the transgenic cohorts. The dose and injection timing of aromatic amino acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT) inhibitors (benserazide and entacapone respectively), have been optimised to avoid fluorodopa metabolism outside the brain. The dose of radiotracer and scanning timings are currently under investigation with further pilot scans. We will start imaging the transgenic cohorts at the beginning of 2018, and we anticipate to complete data acquisition and analysis by the end of the year. With the outputs generated from this research, we will be able to apply for further funding to advance our use of molecular imaging for model characterisation and, in the future, for studies evaluating promising candidate compounds to modify disease progression. |
| Start Year | 2016 |
| Description | Oxford collaboration for molecular imaging (PET) in a rodent model of Parkinson's disease. |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Richard Wade-Martins' lab has engineered rodent models of Parkinson's disease: LRRK2 BAC transgenic rats expressing human wild-type, G2019S, or R1441C LRRK2 mutations. These models have been extensively characterised using behavioural tests, voltammetry, electrophysiological recordings and immunohistochemistry analyses, showing that transgenic rats aged 18-21 months bearing any of the LRRK2 mutations exhibit L-DOPA responsive motor dysfunction, impaired striatal dopamine release, and cognitive deficits, but with no apparent neurodegeneration or protein accumulation on histology. In collaboration with the Imaging Core at the Oncology Department, we have optimised a scanning protocol for the aged rat-cohorts that will allow the acquisition of 18F-DOPA PET data to further characterise the effect of these mutations on dopamine metabolism, and validate these rodent models for future imaging studies. The aim is to provide early imaging readouts for the response to therapy with candidate compounds in an animal model of the early stages of PD. |
| Collaborator Contribution | This collaboration allows us to bring new methods to OPDC. Our collaborators provide the radiotracers needed to perform our molecular imaging studies (fluorodopa is not routinely produced or distributed), and the facilities and expertise to run our scans. Veronique Gouverneur's lab has pioneered a new synthesis route for fluorodopa, and they are currently working to scale it up to production level for us. Sean Smart and Veerle Kersemans run the PET facility at the Oncology Department and have optimised the imaging logistics, and helped with acquisition protocols and data reconstruction so we are able to scan our aging cohorts in time. |
| Impact | Initial pilot studies have been performed to detect and address imaging-specific problems before starting the analysis of the transgenic cohorts. The dose and injection timing of aromatic amino acid decarboxylase (AADC) and catechol-O-methyltransferase (COMT) inhibitors (benserazide and entacapone respectively), have been optimised to avoid fluorodopa metabolism outside the brain. The dose of radiotracer and scanning timings are currently under investigation with further pilot scans. We will start imaging the transgenic cohorts at the beginning of 2018, and we anticipate to complete data acquisition and analysis by the end of the year. With the outputs generated from this research, we will be able to apply for further funding to advance our use of molecular imaging for model characterisation and, in the future, for studies evaluating promising candidate compounds to modify disease progression. |
| Start Year | 2016 |
| Description | Prof Clare Mackay with Dr Apostolos Tsiachristas |
| Organisation | University of Oxford |
| Department | Nuffield Department of Population Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Clare Mackay with Dr Apostolos Tsiachristas. Dr Tsiachristas is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). He will also be contributing to the upcoming health economic evaluation of the Brain Health Centre. |
| Collaborator Contribution | Prof Clare Mackay with Dr Apostolos Tsiachristas. Dr Tsiachristas is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). He will also be contributing to the upcoming health economic evaluation of the Brain Health Centre. |
| Impact | Prof Clare Mackay with Dr Apostolos Tsiachristas. Dr Tsiachristas is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). He will also be contributing to the upcoming health economic evaluation of the Brain Health Centre. |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Dr Caroline Potter |
| Organisation | University of Oxford |
| Department | Nuffield Department of Population Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Clare Mackay with Dr Caroline Potter. Dr Potter is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). The quality of life measure developed by Dr Potter will be implemented in the Brain Health Centre. |
| Collaborator Contribution | Prof Clare Mackay with Dr Caroline Potter. Dr Potter is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). The quality of life measure developed by Dr Potter will be implemented in the Brain Health Centre. |
| Impact | Prof Clare Mackay with Dr Caroline Potter. Dr Potter is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). The quality of life measure developed by Dr Potter will be implemented in the Brain Health Centre. |
| Start Year | 2020 |
| Description | Prof Clare Mackay with Dr Catherine Mummery |
| Organisation | University College London |
| Department | Dementia Research Centre (DRC) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Along with Prof Mackay, Dr Mummery is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Collaborator Contribution | Along with Prof Mackay, Dr Mummery is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Impact | Along with Prof Mackay, Dr Mummery is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Dr Catherine Pennington |
| Organisation | University of Bristol |
| Department | Medical School |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Clare Mackay with Dr Catherine Pennington. Along with Prof Mackay, Dr Pennington is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Collaborator Contribution | Prof Clare Mackay with Dr Catherine Pennington. Along with Prof Mackay, Dr Pennington is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Impact | Prof Clare Mackay with Dr Catherine Pennington. Along with Prof Mackay, Dr Pennington is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Dr Chris Kalafatis |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Along with Prof Mackay, Dr Kalafatis is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Collaborator Contribution | Along with Prof Mackay, Dr Kalafatis is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Impact | Along with Prof Mackay, Dr Kalafatis is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Dr Liz Coulthard & Dr Hiliary Archer |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Along with Prof Mackay, Dr Coulthard & Dr Hiliary Archer are members of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Collaborator Contribution | Along with Prof Mackay, Dr Coulthard & Dr Hiliary Archer are members of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Impact | Along with Prof Mackay, Dr Coulthard & Dr Hiliary Archer are members of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Dr Tim Rittman |
| Organisation | University of Cambridge |
| Department | Cambridge Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Along with Prof Mackay, Dr Rittman is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Mackay and team have advised Dr Rittman on the BHC imaging protocol to inform similar activities in Cambridge. |
| Collaborator Contribution | Along with Prof Mackay, Dr Rittman is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Mackay and team have advised Dr Rittman on the BHC imaging protocol to inform similar activities in Cambridge. |
| Impact | Along with Prof Mackay, Dr Rittman is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Mackay and team have advised Dr Rittman on the BHC imaging protocol to inform similar activities in Cambridge. |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Dr Tobias Langheinrich & Dr Ross Dunn |
| Organisation | Hospital and Greater Manchester Neuroscience Centre |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Along with Prof Mackay, Dr Langheinrich is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation |
| Collaborator Contribution | Along with Prof Mackay, Dr Langheinrich is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Dr Dunn is using the research protocols for the Oxford BHC, which Prof Mackay leads, to set up a BHC in Manchester. |
| Impact | Along with Prof Mackay, Dr Langheinrich is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Dr Dunn is using the research protocols for the Oxford BHC, which Prof Mackay leads, to set up a BHC in Manchester. |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Prof Alastair Burns |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Burns is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). |
| Collaborator Contribution | Prof Burns is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). |
| Impact | Prof Burns is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). |
| Start Year | 2020 |
| Description | Prof Clare Mackay with Prof James Rowe |
| Organisation | University of Cambridge |
| Department | Department of Clinical Neurosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Along with Prof Mackay, Prof Rowe is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Rowe is also PI on a research project that's Oxford site falls under Prof Mackay's BRC theme New Therapeutics in Alzheimer's Disease (NTAD). |
| Collaborator Contribution | Along with Prof Mackay, Prof Rowe is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Rowe is also PI on a research project that's Oxford site falls under Prof Mackay's BRC theme New Therapeutics in Alzheimer's Disease (NTAD). |
| Impact | Along with Prof Mackay, Prof Rowe is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Rowe is also PI on a research project that's Oxford site falls under Prof Mackay's BRC theme New Therapeutics in Alzheimer's Disease (NTAD). |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Professor Dag Aarsland |
| Organisation | King's College London |
| Department | Institute of Psychiatry, Psychology & Neuroscience |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Along with Prof Mackay, Prof Aarsland is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Aarsland is also PI on a research project that's Oxford site falls under Prof Mackay's BRC theme; Remote assessment of disease and relapse - Alzheimer's disease(RADAR-AD) |
| Collaborator Contribution | Along with Prof Mackay, Prof Aarsland is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Aarsland is also PI on a research project that's Oxford site falls under Prof Mackay's BRC theme; Remote assessment of disease and relapse - Alzheimer's disease(RADAR-AD) |
| Impact | Along with Prof Mackay, Prof Aarsland is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. Prof Aarsland is also PI on a research project that's Oxford site falls under Prof Mackay's BRC theme; Remote assessment of disease and relapse - Alzheimer's disease(RADAR-AD) |
| Start Year | 2019 |
| Description | Prof Clare Mackay with Professor Philip Scheltens |
| Organisation | VU University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Prof Clare Mackay and Professor Philip Scheltens. Prof Scheltens is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). |
| Collaborator Contribution | Prof Clare Mackay and Professor Philip Scheltens. Prof Scheltens is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). |
| Impact | Prof Clare Mackay and Professor Philip Scheltens. Prof Scheltens is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). |
| Start Year | 2020 |
| Description | Prof. Clare Mackay & Dr Lola Martos |
| Organisation | Oxford Health NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Dr Martos is the clinical lead for the new Brain Health Centre (BHC), for which Prof Mackay is the research lead/PI. Patients who attend the BHC brain health assessment for medical tests are also given the opportunity to take part in research. This research will help improve the diagnosis and treatments available for people with memory problems. The brain health assessment is a pilot as part of longer-term project to improve memory services. This pilot phase, jointly led by Professor Clare Mackay (BRC Theme Lead) and Dr Lola Martos (Clinical Lead) will include 150 patients from the South Oxfordshire clinic over a 6-month period. The objective is to provide better quality data to 'empower' the diagnosis and to create the translational interface for evaluating new imaging/cognitive biomarkers. |
| Collaborator Contribution | Dr Martos is the clinical lead for the new Brain Health Centre (BHC), for which Prof Mackay is the research lead/PI. Patients who attend the BHC brain health assessment for medical tests are also given the opportunity to take part in research. This research will help improve the diagnosis and treatments available for people with memory problems. The brain health assessment is a pilot as part of longer-term project to improve memory services. This pilot phase, jointly led by Professor Clare Mackay (BRC Theme Lead) and Dr Lola Martos (Clinical Lead) will include 150 patients from the South Oxfordshire clinic over a 6-month period. The objective is to provide better quality data to 'empower' the diagnosis and to create the translational interface for evaluating new imaging/cognitive biomarkers. |
| Impact | Launch of BHC joint clinical-research service, MOU between OU and OH, BHC position paper (in prep) |
| Start Year | 2018 |
| Description | Prof. Clare Mackay with Professor Craig Ritchie |
| Organisation | University of Edinburgh |
| Department | Centre for Clinical Brain Sciences (CCBS) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof. Clare Mackay with Professor Craig Ritchie.Prof Ritchie is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). Along with Prof Mackay, Prof Ritchie is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Collaborator Contribution | Prof. Clare Mackay with Professor Craig Ritchie.Prof Ritchie is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). Along with Prof Mackay, Prof Ritchie is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Impact | Prof. Clare Mackay with Professor Craig Ritchie.Prof Ritchie is a collaborator on a recent grant application lead by Prof Mackay (outcome pending). Along with Prof Mackay, Prof Ritchie is a member of the Brain Health Clinics UK network. A position paper for this network is in preparation. |
| Start Year | 2019 |
| Description | Quyen Do in collaboration with Cook and Walsh labs from the Department of Engineering at Oxford University |
| Organisation | University of Oxford |
| Department | Department of Engineering Science |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We initiated the collaboration with the main objective being to develop an advanced in vitro culture system of human neuronal circuits amenable to wider and more sophisticated experiments. We provided expertise on human neuronal culturing in vitro, neural circuit and biological knowledge which is critical to design and empirically assess the utility of their platform to attain our culturing objective. |
| Collaborator Contribution | They provided technical expertise and instrumentation to fabricate useful fluid-walled microfluidic platforms which was previously developed within their lab for the purpose of culturing human neuronal circuits in vitro. |
| Impact | Together, we have successfully established a paradigm to culture human neuronal microcircuits on fluid-walled microfluidics which is adaptable for multiple experimental purposes. Manuscript for this project is in preparation. |
| Start Year | 2022 |
| Description | Rachel Heon Roberts in collaboration with the Kakura laboratory, University of Oxford |
| Organisation | University of Oxford |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | I am providing expertise regarding alpha-synuclein aggregation, and we are also providing some of the equipment (PheraStar, bacterial shaker). |
| Collaborator Contribution | The Kukura lab is also providing some of the equipment and expertise, surrounding the mass photometer microscope, as well as performing almost all the manipulations (alpha-synuclein aggregation and Thioflavin T assay, mass photometry readings and data analysis). |
| Impact | This collaboration was started in 2022 and has not yet produced any publications. |
| Start Year | 2022 |
| Description | Rachel Heon Roberts in collaboration with the Magill laboratory, University of Oxford |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Brain Network Dynamics Unit at the University of Oxford (BNDU) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | I am growing the cell lines, providing samples for optimisation of the technique, providing the reagents for cell culture and immunocytochemistry, as well as performing most of the manipulations. |
| Collaborator Contribution | The Magill lab is assisting with their expertise, providing the equipment needed (ex ultramicrotome, electron microscope), and the reagents needed for electron microscopy. |
| Impact | We have not yet published, but the abstracts I have sent to conferences this year feature some of the results obtained from this collaboration. |
| Start Year | 2021 |
| Description | Rodent fMRI imaging |
| Organisation | ETH Zurich |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | OPDC provides mouse models of Parkinson's |
| Collaborator Contribution | ETH carries out fMRI scanning on mice |
| Impact | Ongoing project |
| Start Year | 2016 |
| Description | Stem cell generation |
| Organisation | University of Oxford |
| Department | Sir William Dunn School of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We work with the Oxford Stem Cell Facility at Pathology to study induced pluripotent stem cells of certain MAPT genotypes |
| Collaborator Contribution | The Stem Cell Facility provides stem cells of certain MAPT genotypes for differentiation into neurons |
| Impact | None yet |
| Start Year | 2012 |
| Description | Structural and functional connectivity in the human basal ganglia in health and disease using high resolution MRI at 7T |
| Organisation | University of Oxford |
| Department | Nuffield Department of Clinical Neurosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | FMRIB scans and clinical data from our cohort |
| Collaborator Contribution | Investigate in vivo connectivity of human basal ganglia. |
| Impact | Ongoing research |
| Start Year | 2016 |
| Description | T cell reactivity to alpha-synuclein |
| Organisation | Bristol-Myers Squibb |
| Department | Celgene |
| Country | United States |
| Sector | Private |
| PI Contribution | Interaction with Celgene scientists on Parkinson's immuniology |
| Collaborator Contribution | Mentorship of early career researcher |
| Impact | New post-doc appointed |
| Start Year | 2019 |
| Description | The genetic background of REM sleep behaviour disorder and its conversion to synucleinopathies. |
| Organisation | McGill University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Providing DNA samples from our cohort |
| Collaborator Contribution | Analsying with 2 plaforms using advanced genetic methods.They have already analysed about 500 RBD patients, 600 PD patients and about 1000 controls, with very encouraging results. |
| Impact | Ongoing research |
| Start Year | 2017 |
| Description | Twinning: Centre PD |
| Organisation | University of Luxembourg |
| Department | Faculty of Science, Technology and Communication |
| Country | Luxembourg |
| Sector | Academic/University |
| PI Contribution | OPDC will share information on clinical cohorts, stem cells and neuropathology |
| Collaborator Contribution | Centre PD will share information on clinical cohorts, stem cells and neuropathology Centre PD worked with us on the EU Twinning grant to facilitate OPDC clinical data base move from Open Clinica to Red Cap System |
| Impact | Ongoing |
| Start Year | 2015 |
| Description | UK Dementia Platform (DPUK) |
| Organisation | Medical Research Council (MRC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Many OPDC members play a leading role in the DPUK. Richard Wade-Martins head the DPUK National Dementia Stem Cell Network, Simon Lovestone heads Informatics component and Clare MacKay leads on informatics analysis of imaging. Richard and Simon are on thr DPUK Executive Committee. |
| Collaborator Contribution | The MRC Dementias Platform UK (DPUK) is a £53M public-private partnership, developed and led by the Medical Research Council, to accelerate progress in, and open up, dementias research. The DPUK's aims are early detection, improved treatment and ultimately, prevention, of dementias. |
| Impact | The DPUK launched in Autumn 2014. It is directed by Dr John Gallacher at the University of Cardiff, together with an executive team of investigators drawn from seven universities (Cambridge, Edinburgh, Imperial College London (ICL), Oxford, Newcastle, University College London (UCL) and Swansea), including the UCL-based MRC Unit for Lifelong Health and Ageing. The clinical research infrastructure award links DPUK with further universities, Manchester and Bristol. |
| Start Year | 2014 |
| Description | UKCRIS collaboration with OHDSI |
| Organisation | Observational Health Data Sciences and Informatics |
| Sector | Charity/Non Profit |
| PI Contribution | The UKCRIS network comprises 11 NHS Trusts across the UK. This collaboration led to the development of an Information Governance agreement to underpin the operation of a federated access model, avhieving data harmonisation with access to 2.2m de identied health records. UKCRIS is now registered as a member of the OHDSI community and has its data model catalogued on the OHDSI portal. |
| Collaborator Contribution | We worked with the EMIF data team to define an approach to mapping the CRIS dataset to the OMOP clinical data model |
| Impact | Information Governance agreement for Federated data access |
| Start Year | 2017 |
| Description | "How our brains work" Clare MacKay |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Clare MacKay conducted "how our brains work" activities during Brain Awareness Week at Hagbourne CofE Primary school (02/16). Each class in turn was given an age-appropriate talk on the neuroscience of a 'growth mindset'. Clare MacKay also gave 'neuroscience for teachers' and 'Growth Mindset for parents' talks for the school. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.facebook.com/hagbourneschool/posts/953838178043436 |
| Description | "The Funny Side of Parkinson's" |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | "The Funny Side of Parkinson's" on BBC1. Paul Mayhew-Archer Documentary. Richard Wade-Martins and Fahd Baig appeared to talk about OPDC. Paul was named best presenter at the Grierson Awards for this documentary. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/iplayer/episode/b072xkcz/inside-out-south-parkinsons-the-funny-side |
| Description | #DementiaActionWeek2018 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Sharing content to promote #DementiaActionWeek2018 including producing original video of researcher |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://twitter.com/WadeMartinsLab/status/999632001920651264 |
| Description | 2018 article published on iPS research in Oxford in Phenotype (Oxford Biochemical society magazine) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A decade of IPS cell research in Oxford by Sally Cowley Phenotype is the magazine of the Oxford University Biochemical Society. It is run by students and staff and published on a termly basis. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://issuu.com/phenotypejournal/docs/mt18 |
| Description | 2018/19 OPDC Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | We produced a newsletter on OPDC activities. This was sent to all study participants, those on OPDC news mailing list and will be handed out at events. |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc2018-19-newsletter.pdf |
| Description | A-Level workshop in the Oxford Natural History museum |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A-Level workshop in the Oxford Natural History museum March 2017 Naiara Demnitz |
| Year(s) Of Engagement Activity | 2017 |
| Description | ARUK Dementia Open morning - postponed 3 days before event took place due to COVID-19 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The 2020 Dementia Awareness Day was held at the John Radcliffe Hospital in Oxford in March 2020. The Thames Valley ARUK Network Centre organise this event to discuss current dementia research taking place within the network centre, which includes the University of Oxford, Oxford Brookes University and University of Reading. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.oxdare.ox.ac.uk/arukox-public |
| Description | ARUK Network Open Morning |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | About 150-200 people attended a morning of talks from Oxford researchers, including presentations on using stem cells in dementia research. |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | ARUK Oxford Network Research Day presentation July 2019 - Bryan Ng |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | In July 2019, Bryan Ng attended the ARUK Oxford Network Research Day and gave a presentation |
| Year(s) Of Engagement Activity | 2019 |
| Description | ARUK Oxford network dementia information event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Open day of talks and information stands organised by Alzheimer's UK Oxford Research Network at John Radcliffe Hospital. Talk by Sana Suri on Brain-Heart links |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.oxdare.ox.ac.uk/public-events |
| Description | ARUK Thames Valley Network Dementia Research day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 1st July 2022, The ARUK Thames Valley network hosted a Dementia Research day. The host was Becky Carlyle, ARUK Thames Valley Network coordinator. The day include presentations by Becky Carlyle, Peter Kilfeather, Hugo Fernandes, and Maria Claudia Caiazza from the Wade-Martins lab. |
| Year(s) Of Engagement Activity | 2022 |
| Description | ARUK Thames Valley Network Translational Research in Dementia - Collaboration building event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On Friday 11th November 2022, the ARUK Thames Valley Network hosted a Translational Research in Dementia - Collaboration building event at Oxofrd Brookes University. The event was hosted by Becky Carlyle ARUK Thames Valley Network coordinator and Dr Patrick Esser, ARUK Thames Valley Network Committee member. It was attended by researchers from Oxford Brookes University, University of Oxford and the University of Reading. |
| Year(s) Of Engagement Activity | 2022 |
| Description | ARUK YouTube Channel |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | You tube channel for Alzhiemer's Research UK Oxford network centre. Includes talks from open days, panel discussions and short Q&A videos. |
| Year(s) Of Engagement Activity | 2015,2017,2018 |
| URL | https://www.youtube.com/channel/UCU_wr013kmYXypvNCRzU3JA |
| Description | ARUK conference poster presentation in March 2020 - Bryan Ng - EVENT CANCELLED DUE TO CORONAVIRUS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | ARUK conference poster presentation in March 2020 - Bryan Ng |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.alzheimersresearchuk.org/for-researchers/research-conference-2020/abstracts/ |
| Description | ARUK/BRC Oxford Dementia Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | a day of talks celebrating the exciting research in the region including updates on some of the exciting big dementia research initiatives such as the ARUK Oxford Drug Discovery Institute, Dementia Platform UK, the NIHR Oxford Health Biomedical Research Centre and the Oxford Momentum Award. Accredited for 5 CPD credits. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.dpag.ox.ac.uk/research/wade-martins-group/oxford-aruk-network-centre/research-day-2015 |
| Description | Academic Health Science Networks Webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Clare Mackay was invited to preset an AHSN Webinar in June 2017 |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://atlas.ahsnnetwork.com/ |
| Description | Ajantha Abey presented a poster at the at DPUK Translation conference 23. title: 'Investigating Selective Neuronal Vulnerability in Alzheimer's and Parkinson's Disease Using Induced Pluripotent Stem Cells'. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In March 2023, Ajantha Abey presented a poster at the at DPUK Translation conference 23 |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.dementiasplatform.uk/research-hub/translation-2023 |
| Description | Aligning Science Across Parkinson's (ASAP) Consortium Meeting on 1st and 2nd September 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 1st and 2nd September 2022, the first Aligning Science Across Parkinson's (ASAP) Consortium Meeting was held at the Department of Pharmacology, University of Oxford. The two day event included talks and posters from the Wade-Martins lab, the Cragg lab, the Magill lab, and from our collaborators Mark Howe (Boston) and Dinos Meletis (Karolinska). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://twitter.com/ASAP_Research/status/1585270635118428163 |
| Description | Alzheimer's Research UK Thames Valley Network dementia public evening event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | On 12 October 2022, Becky Carlyle gave a public talk on behalf of the Alzheimer's Research UK Thames Valley Network at Keble College. The talk focussed on the accusations of scientific fraud in Alzheimer's Disease research that were reported in the press in July, and the implications of these accusations for patients, researchers, and the race to cure Alzheimer's Disease. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.eventbrite.co.uk/e/alzheimers-research-uk-thames-valley-network-dementia-public-evening-... |
| Description | Annual meeting of Organization for Human Brain Mapping (OHBM), Vancouver |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Vaanathi Sundaresan:Poster: "Modelling white matter hyperintensities distribution within a population using Bayesian Inference." Eniko Zsoldos: Poster: 'Mid-life composite measures of biological aging predict structural integrity measures in later life'. Johannes Klein Poster "Prefrontal network dysfunction in prodromal and manifest Parkinson's disease" |
| Year(s) Of Engagement Activity | 2017 |
| Description | Article featured on the DPUK website (Can a type of supportive brain cell rescue neurons damaged by Parkinson's disease? - DPUK (dementiasplatform.uk)) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In October 2021, an article about Naroa Ibarra Aizpurua's research was featured on the DPUK website, titled, 'Can a type of supportive brain cell rescue neurons damaged by Parkinson's disease?' |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dementiasplatform.uk/research-hub/stem-cell-network/can-a-type-of-supportive-brain-cell-... |
| Description | Attend Parkinson's UK engagement event at St James' Palace, London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Attend reception at St James' Palace to raise awareness for Parkinson's disease |
| Year(s) Of Engagement Activity | 2018 |
| Description | Attended the ARUK Oxford Network Outreach Day in March 2019 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The 2019 Dementia Awareness Day was held at the John Radcliffe Hospital in Oxford in March 2019. The Oxford ARUK Network Centre organise this event to discuss current dementia research taking place within the network centre, which includes the University of Oxford, Oxford Brookes University and University of Reading. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.oxdare.ox.ac.uk/openday2019 |
| Description | BBC One Saturday Breakfast News - Funny Side of Parkinson's |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Richard Wade-Martins appeared on BBC One Saturday Breakfast News with Paul Mayhew-Archer to discuss our research using stem cell technology to grow and study dopamine neurons from skin cells. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.co.uk/news/health-35734888 |
| Description | Behaviour Health Centre (BHC) PPI advisory group (online) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | In May 2020 Clare Mackay gave input on a survey for memory clinic patients on attitudes to remote/virtual assessments and appointments to the BHC PPI advisory group (online) -- |
| Year(s) Of Engagement Activity | 2020 |
| Description | Biochemistry Society LRRK2 Meeting, Lille, France |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 30 June 2022, Professor Wade-Martins gave a talk titled, 'The role of LRRK2 in the autophagic/lysosomal pathway' at the Biochemistry Society LRRK2 Meeting, Lille, France |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.eventsforce.net/biochemsoc/frontend/reg/tAgendaWebsite.csp?pageID=44265&daySelector=3&ev... |
| Description | Blog by Bryan Ng on DPUK website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A Blog was written and posted on the DPUK website on 21 April 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.dementiasplatform.uk/news-and-blogs/blog/pioneering-stem-cell-research-dementia |
| Description | Blog by Bryan Ng on DPUK website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on DPhil student Bryan Ng's project in Richard Wade-Martins' lab. Disease-in-a-dish studies open a window to a new level of detail in dementia |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.dementiasplatform.uk/blog/disease-in-a-dish-studies-open-a-window-to-a-new-level-of-deta... |
| Description | British Neuroscience Association Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Sana Suri: Talk: British Neuroscience Association Conference, Birmingham April 2017: "The APOE Paradox" |
| Year(s) Of Engagement Activity | 2017 |
| Description | Bryan Ng attended the Alzheimer's Association International Conference and presented a poster in July 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | In July 2019, Bryan Ng attended the Alzheimer's Association International Conference and presented a poster. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://c-path.org/poster-presentation-at-the-2019-alzheimers-association-international-conference-j... |
| Description | Caution when looking at cell recycling in Parkinson's |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Media press release by Parkinson's UK highlighting that researchers at the Oxford Parkinson's Disease Centre have shown that cell recycling in Parkinson's may play a more complex role than previously thought. These new results have been published in the journal of Cell Reports. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.parkinsons.org.uk/news/caution-when-looking-cell-recycling-parkinsons |
| Description | Celebrating international day of women and girls in science. |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In February 2022, we celebrated international day of women and girls in science by sharing a video featuring three of our researchers Becky Carlyle, Charmaine Lang, and Gabriela Vilema Enriquez |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://youtu.be/U0yGdxZ7k2A |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands-on experiments, the MakerShack, our brand new Cyber Zone, heartbeat art there was much to explore on site in 2018! From stargazing, fun activity trails, family days and heated discussions in the Conversation Corner to a large animal dissection live on the Festival site, Cheltenham Science Festival offers science galore for all ages. Dr Tara Caffrey took part in the day to talk about her research into Tau. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.cheltenhamfestivals.com/science |
| Description | Clare Mackay talk - New developments in Parkinson's and Alzheimer's research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | OPDC's Imaging lead Professor Clare Mackay and Masud Husain, Professor of Neurology and Cognitive Neuroscience, spoke at a talk open to all about "New developments in Parkinson's and Alzheimer's research". In this accessible and informative public talk they explored the latest research into the debilitating neurodegenerative disorders Alzheimer's and Parkinson's. They showed how cutting edge research is: increasing our knowledge of the mechanisms causing these disorders, offering the prospect of earlier diagnosis and supporting the development of potential new therapies to slow the progression of the disease. The talk was filmed as is available to view online |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://youtu.be/WtmCPdTdmPc |
| Description | Collaborative visit to Oxford by University of Sheffield on Tuesday 27 September |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Researchers from the University of Sheffield visited Oxford in September to discuss new data from our Michael J Fox funded Parkinson's project |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://twitter.com/HeatherMortiboy/status/1575834919724789763 |
| Description | Creation of wademartinslab_oxford instgram account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Account for Wade-Martins lab for Molecular Neurodegeneration, University of Oxford to share news |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.instagram.com/wademartinslab_oxford/ |
| Description | DPUK Stakeholders Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Raised awareness of use of stem cells in dementia research |
| Year(s) Of Engagement Activity | 2015 |
| Description | DPUK Website feature iPSCs: a shared resource |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Information on iPSC labs on DPUK website accessible in the "For Researchers" tab then "Our Research Communities" |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | https://www.dementiasplatform.uk/our-impact/ipscs-a-shared-resource |
| Description | Danish Stem Cell Society Annual Conference: Stem Cells and Personalized Medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 19 September 2022, Dr Sally Cowley gave a talk at the Danish Stem Cell Society Annual Conference: Stem Cells and Personalized Medicine |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://dascs.dk/wp-content/uploads/2022/06/Flyer_Stamcelle_2022_NY_02-1.pdf |
| Description | Daybreak Lectures on issues around dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Phillippa Carling gave a brief overview of her work on drug discovery lab at ODDI, with some videos of some of their equipment. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Dementia Awareness Morning - Bryan Ng |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Bryan Ng helped out at a dementia awareness event at the John Radcliffe Hospital. This was a morning of talks about research into dementia in and around Oxford and a chance for the public to meet researchers and find out about support services available for people living with dementia. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oxdare.ox.ac.uk/public-events |
| Description | Department's Science in the Park event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Researchers joined in the Department's Science in the Park event where children joined Scientists from the Department of Physiology, Anatomy, and Genetics in University Parks where they learnt more about how bodies work. |
| Year(s) Of Engagement Activity | 2022,2023 |
| URL | https://www.dpag.ox.ac.uk/news/dpag-and-biochemistry-inspire-local-children-with-second-science-in-t... |
| Description | Discovery Cohort open day,16 Sept 2019. An afternoon of research updates and engagement with 200 People with Parkinson's and their families |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | On Monday 16th September, a FREE open afternoon of talks was held by OPDC scientists and clinicians. The event was held for study participants and their families. The talks included finding out how participants in the Discovery Cohort is improving our understanding of Parkinson's and driving us closer to a cure. Programme 13:00 Michele Hu Welcome 13:05 George Tofaris Blood based biomarkers for Parkinson's 13:25 Tom Barber Parkinson's and Sleep 13:45 Christine Lo Sense of smell in RBD and Parkinson's 14:05 Claire Guest & Amelia Kramer Medical Detection Dogs 14:35 Break & Refreshments 15:05 Francesca Bowring Research priorities for Parkinson's 15:25 Ludovica Griffanti Brain Imaging for Parkinson's 15:45 Michael Lawton Two sample Mendelian Randomisation of disease progression 16:05 Michele Hu Managing your symptoms and living well with Parkinson's 16:30 Discussion Q&A |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/openday2019 |
| Description | Downing Street |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Inivitation to attend reception at 10, Downing Street |
| Year(s) Of Engagement Activity | 2017 |
| Description | Dr Dayne Beccano-Kelly became an international science ambassador for the World Parkinson's Congress 2022. |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Dayne Beccano-Kelly became an international science ambassador for the World Parkinson's Congress 2022.Their focus leading up to the Congress is to help drive up participation of scientists to attend the WPC. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://wpc2022.org/page/2022ScienceAmb |
| Description | Dr Dayne Beccano-Kelly established the Aspiring Black Physiologists award with the Physiological Society |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Dr Dayne Beccano-Kelly, along the Physiological Society established the Aspiring Black Physiologists award to address the disparity of black scientist in STEM research by encouraging black students at young ages to engage with and consider science research as a viable career path. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.physoc.org/careers/supporting-your-next-career-move/aspiring-black-physiologists/. |
| Description | Dr Dayne Beccano-Kelly gave a talk at the Neurodegeneration Challenge Network (NDCN) online forum funded by the Chan Zuckerberg initiative (CZI) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 10th September 2020, Dr Dayne Beccano-Kelly gave a talk at the Neurodegeneration Challenge Network (NDCN) online forum funded by the Chan Zuckerberg initiative (CZI) |
| Year(s) Of Engagement Activity | 2020 |
| Description | Dr Dayne Beccano-Kelly gave a talk at the SelectScience Virtual Neuroscience Summit 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Dayne Beccano-Kelly gave a talk at the SelectScience Virtual Neuroscience Summit 2020. The presentation tiles was 'Once upon a time at the synapse: A tale of early dysfunction in Parkinson's Disease' The presentation was recorded and featured on the Scientists' Channel: https://thescientistschannel.com/dayne-beccano-kelly |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://neurosciencesummit2020.vfairs.com/en/#home |
| Description | Dr Dayne Beccano-Kelly gave a talk on "Diversity in Teaching" to the Physiological Society as part of their webinar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Dayne Beccano-Kelly gave a talk on "Diversity in Teaching" by the Physiological Society He spoke about his project to make the study of physiology more appealing to BAME populations by using a competition asking participants to identify culturally appropriate role models. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.physoc.org/events/diversity-in-teaching/ |
| Description | Dr Dayne Beccano-Kelly was interviewed by Parkinson's UK about Parkinson's Research and Diversity |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | In December 2020, Dr Dayne Beccano-Kelly gave an interview to Parkinson's UK about Research and Diversity |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://medium.com/parkinsons-uk/a-researchers-view-parkinson-s-research-and-diversity-ecbee4720359 |
| Description | Dr Dayne Beccano-Kelly was recognised for his contribution to science research by University of Oxford during Black History Month: |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | During Black History Month, the University highlighted the power of excellence and academic achievement, past and present, and how the contributions of Black people have contributed to the calibre of the University's reputation. Dr Dayne Beccano-Kelly was recognised for his contribution to science research by University of Oxford during Black History Month. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://medium.com/oxford-university/the-oxford-bhm-100-7af54c5b2764 |
| Description | Dr Mootaz Salman gave a talk at the Department of Stem Cell Biology- Innovative Medical Centre in Vilnius/ Lithuania. Presentation title: 3D organ-on-a-chip models to investigate CNS disorders. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 27 January 2022, Dr Mootaz Salman gave a talk at the Department of Stem Cell Biology- Innovative Medical Centre in Vilnius/ Lithuania. Presentation title: 3D organ-on-a-chip models to investigate CNS disorders. |
| Year(s) Of Engagement Activity | 2022 |
| URL | http://www.imcentras.lt/en/ |
| Description | Dr Mootaz Salman gave an in person talk as part of the DPAG Head of Department: Fellows in Pair Lecture seminar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 4 February, Dr Mootaz Salman gave a talk as part of the DPAG Head of Department: Fellows in Pair Lecture seminar series. His presentation title was "Defining mechanisms of blood-brain barrier dysfunction in dementia using advanced organ-on-a-chip models" |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talks.ox.ac.uk/talks/id/bbab1b2e-6e4b-4f57-a607-4b0d58d5f419/ |
| Description | Dr Natalie Connor-Robson gave an online talk to the Parkinson's UK Henley Branch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | On 24th February Dr Natalie Connor-Robson gave an outreach talk to the Henley Parkinson's UK Branch |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dr Nora Bengoa-Vergniory & Dr Sophie Morgan gave an online presentation for the ARUK Thames Valley Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Due to the COVID-19 pandemic, we were unable to hold the 2020 Alzheimer's Research UK Thames Valley Network Dementia Open Morning. Over the summer presenters within the network centre who were due to talk at the March public event to give their talks online. The short talks from scientists were recorded and include a range of topics in dementia. They are available on YouTube. Sophie Morgan presentation title was 'Protein aggregation and Parkinson's disease' Nora Bengoa-Vergniory presentation title was 'Microscopic tweezers, a new avenue for treatment of neurodegenerative diseases'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/playlist?list=PLPN7gkQCguDT-JdBjLXyTxJ_i7wCXhjYO |
| Description | Dr Pavandeep Rai was a judge in an Beyond Boundaries 2020 competition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Pavandeep Rai was a judge in an Beyond Boundaries 2020 competition; an outreach event to schools in Oxfordshire. The University of Oxford invited schools to participate in an art competition for Oxfordshire state school students to create art inspired by research from Black, Asian and Minority Ethnic scientists. Students were asked to choose one of six scientists to create an artistic response to their research (e.g. painting, drawing, sculpture, animation, other artistic media) along with a short statement explaining the artwork. Due to COVID-19, there was a delay to announcing the winners. The winners are to be called in January 2021 and an exhibition of their work will take place online now. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.oxfordsparks.ox.ac.uk/content/beyond-boundaries-2020 |
| Description | Dr Sally Cowley gave a talk at the Cambridge Neuro Network Chan-Zuckerburg Initiative |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 22 October, Dr Sally Cowley gave a talk at the Cambridge Neuro Network Chan-Zuckerburg Initiative. Title: Modelling neuroinflammation using human induced Pluripotent Stem cell-derived microglia |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.neuroscience.cam.ac.uk/news/article.php?permalink=9c3213a467 |
| Description | Dr Sally Cowley gave a talk at the European Microglia Seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 2 Nivember Dr Sally Cowley gave an online talk at the European Microglia Seminar Series. Title: Modelling neuroinflammation using human induced Pluripotent Stem cell-derived microglia |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?v=TM5VsEmt1Ts |
| Description | Dr. Nora Bengoa-Vergniory gave a Poster tour presentation at the World Parkinson's Congress, Kyoto Japan. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr. Nora Bengoa-Vergniory gave a Poster tour presentation at the World Parkinson's Congress, Kyoto Japan. Subject: CLR01 protects dopaminergic neurons in vitro and in vivo in mouse and human models |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.worldpdcoalition.org/page/PastCongresses |
| Description | Dr. Nora Bengoa-Vergniory gave a oral presentation at the Neuroscience symposium, Oxford UK (2019). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr. Nora Bengoa-Vergniory gave a oral presentation at the Neuroscience symposium, Oxford UK (2019). |
| Year(s) Of Engagement Activity | 2019 |
| Description | Dr. Nora Bengoa-Vergniory gave an oral presentation at the Parkinson's Disease Gordon Research Conference Seminar, Maine USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr. Nora Bengoa-Vergniory gave an oral presentation at the Parkinson's Disease Gordon Research Conference Seminar, Maine USA June 23 - 28, 2019 Subject: CLR01 protects dopaminergic neurons in vitro and in vivo in mouse and human models |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.grc.org/parkinson-s-disease-conference/2019/ |
| Description | Editorial from Tim Greenamyre on our paper on what's wrong with Mitochondria in Parkinson's |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Editorial in Movement Disorders Journal on our publication |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.ncbi.nlm.nih.gov/pubmed/30288798 |
| Description | Fundraising activity during lockdown for Parkinson's UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | During the Covid pandemic lockdown, members of the Wade-Martins Group from the Oxford Parkinson's Disease Centre fundraised for Parkinson's UK with a variety of imaginative challenges for the national 2.6 challenge campaign. £1,197 was raised for the charity. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.dpag.ox.ac.uk/news/opdc-researchers-hit-target-for-parkinsons-uk-with-2-6-challenge |
| Description | Gordon Research Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Nora Bengoa-Vergniory "Mass-spectrometry approach highlights REST as a potential neuroprotective target for Parkinson's disease in an alpha synuclein overexpressing BAC-transgenic mouse model" Oral presentation Posters: Nora Bengoa-Vergniory, Dayne Beccano-Kelly, Natalie Connor-Robson, Rebecca Wallings |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.grc.org/parkinson-s-disease-conference/2017/ |
| Description | Guest speaker at Alzheimer's Society Dementia Cafe |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Sana Suri - Talk: guest speaker at Alzheimer's Society Dementia Cafe, Oxford September 2017: "The heart-brain link in dementia" |
| Year(s) Of Engagement Activity | 2017 |
| Description | Health Canal article based on HDAC4 paper |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Online news article on HDAC4 paper based on Parkinson's UK press release |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.healthcanal.com/brain-nerves/parkinson/247111-experimental-cancer-drug-shows-promise-for... |
| Description | In March 2023, Kalina Naidoo presented a Blitz Poster (1 minute flash talk + poster) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In March 2023, Kalina Naidoo presented a Blitz Poster (1 minute flash talk + poster) titled, 'An investigation of Gcase modulators in iPSC derived dopaminergic neurons' at the first in-person Parkinson's disease Early Career Researcher (ECR) meeting at the Core Technology Facility, University of Manchester. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Inaugural Fellowship to Charmaine Lang paves the way to improved human models for Parkinson's drug discovery |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Charmaine Lang has been awarded the first jointly funded Senior Research Fellowship from Parkinson's UK and Rosetrees Trust. With this award, Dr Lang will develop complex new induced pluripotent stem cell (iPSC) models that target the interaction between dopamine neurons and astrocytes in the brain and how these fail in the context of Parkinson's. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.dpag.ox.ac.uk/news/inaugural-fellowship-charmaine-lang-improved-human-models-parkinsons-... |
| Description | Institute of Genetics and Biophysics, Naples, Italy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In March 2022, Professor Richard Wade-Martins gave a talk at the Institute of Genetics and Biophysics, Naples, Italy |
| Year(s) Of Engagement Activity | 2022 |
| Description | Interactive workshop on "The Upside-down Brain" at the Ashmolean museum |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Sat 18 March, All day The Upside-Down Brain: Art and Neuroscience at the Ashmolean Family Friendly Event. Naiara Demnitz |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.google.co.uk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0ahUKEwjE172jjO... |
| Description | International alpha-synuclein meeting, Leuven, Belgium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | In April 2022, Professor Richard Wade-Martins was the opening speaker at the International alpha-synuclein meeting in Leuven, Belgium |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.kuleuven.be/brain-institute/events-and-outreach/synuclein-2022-meeting |
| Description | Interview in Civil Service Fast Stream blog - How Stem Cells Can Boost Our Knowledge and Understanding of the Causes of Dementia |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | This is the third and final in a series of interviews carried out by a group of civil servants that have dedicated time to raising money and awareness for dementia via 'The Fund', a Fast Stream initiative. Alison Leishman, Home Office, interviewed Professor Wade-Martins about his research into dementia. Richard discussed OPDC and the DPUK. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://faststream.blog.gov.uk/2016/05/20/the-fascinating-world-of-research/ |
| Description | Invited to talk at the ARUK Dementia Research Day - Dr. Nora Bengoa-Vergniory |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 31July 2019, was invited to talk at the ARUK Dementia Research Day. Subject: CLR01 protects dopaminergic neurons in vitro and in vivo in mouse and human models |
| Year(s) Of Engagement Activity | 2019 |
| Description | Keynote Lecture "REM Sleep Behavior Disorder: a window on prodromal Parkinson's", given by Prof Michele Hu at a NIH Global Doctoral Partnership Programme Virtual Workshop, Bethesda, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote Lecture "REM Sleep Behavior Disorder: a window on prodromal Parkinson's", given by Prof Michele Hu at a NIH Global Doctoral Partnership Programme Virtual Workshop, Bethesda, USA |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://biomedalliance.org/wp-content/uploads/2020/06/Alliance-Journal-2020.pdf |
| Description | Mark Kelly Parkinson Voice Project lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Mark Kelly spoke at a Parkinson Voice Project lecture presented in the Clark and Brigid Lund Parkinson's Education Center. The talk was streamed live and is available online. This lecture explores what we know so far about impulse control behaviours in Parkinson's and takes a look at work being carried out by the Oxford Discovery Project to better understand these effects. This knowledge helps not only in better directing available therapies, but also improves our understanding of some of the underlying pathological processes involved in Parkinson's. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.opdc.ox.ac.uk/impulse-control-behaviours-and-creativity-in-parkinson-s |
| Description | Medical Express article on HDAC4 paper |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on HDAC4 publication based on Parkinson's UK press release. Medical Xpress is a web-based medical and health news service that is part of the renowned Science X network. Based on the years of experience as a Phys.org medical research channel, started in April 2011, Medical Xpress became a separate website. Branching out with Phys.org's monthly 2.5 million readership, Medical Xpress features the most comprehensive coverage in medical research and health news in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more. Readers of Medical Xpress will have access to the same features offered on Phys.org, such as article comments, ranking, the ability to save favorite articles, a personal account page, easy sharing, podcasts, iPhone/iPad/Android apps and other options. Readers may follow Medical Xpress on Facebook, Twitter or through a variety of customizable RSS feeds and e-Newsletter for the latest in medical research and health news. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://medicalxpress.com/news/2018-12-experimental-cancer-drug-parkinson.html |
| Description | Monthly attendance a the Parkinson's UK Oxford branch meetings |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | During 2022, members of the Wade-Martins lab attend in person the monthly Parkinson's UK Oxford Branch meetings to meet with PWP. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://oxfordparkinsons.org.uk/ |
| Description | Mootaz Salman appointed Departmental Research Lecturer |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In December 2021, Dr Mootaz Salman was conferred the title of Departmental Research Lecturer in recognition of his contribution to his research group and the teaching and research mission of DPAG. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dpag.ox.ac.uk/news/mootaz-salman-appointed-departmental-research-lecturer |
| Description | Movement Disorders Society 2020 Virtual Congress Teaching Course Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 15 September 2020, Professor Michele Hu gave a lecture at the Movement Disorders Society 2020 Virtual Congress. The title of the talk was 'What Makes a Good Biomarker?' |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.mdscongress.org/Congress-Branded/Congress-2020-Files/ic20-prelim.pdf |
| Description | Neurogune talks, Bilbao Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | "Alpha-synuclein overexpressing mice and protection of neurons from synuclein toxicity by molecular tweezers" Oral presentation Nora Bengoa-Vergniory |
| Year(s) Of Engagement Activity | 2017 |
| Description | New Atlas online article on HDAC4 press release |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on HDAC4 paper based on the press release from Parkinson's UK |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://newatlas.com/experimental-cancer-drug-parkinsons/57481/ |
| Description | New item: New study shows clinical symptoms for Alzheimer's can be predicted in preclinical models |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer's brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/news/new-study-shows-clinical-outcomes-for-alzheimers-can-be-predicted-in-... |
| Description | News Article featuring the winners of the DPAG Student Poster Day 2021 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | In November 2021, there was a news article featuring the winners of the DPAG Student Poster Day 2021. One of the runners up was Tara Diviney from the Wade-Martins lab. Tara Diviney, supervised by Dr Natalie Connor-Robson, Professor Stephanie Cragg and Professor Richard Wade-Martins, with "Characterisation of a novel GBA-L444P BAC transgenic mouse model of Parkinson's disease". |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dpag.ox.ac.uk/news/winners-of-the-dpag-student-poster-day-2021-announced |
| Description | News Item: Charmaine Lang appointed Departmental Research Lecturer |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Charmaine Lang has been conferred the title of Departmental Research Lecturer in recognition of her contribution to her research group and the teaching and research mission of DPAG. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/news/charmaine-lang-appointed-departmental-research-lecturer |
| Description | News article as researchers from the OPDC and the Wade-Martins Group move |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In June 2021, researchers from the OPDC and the Wade-Martins Group recently moved to brand new laboratory facilities at the Kavli Institute for NanoScience Discovery. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dpag.ox.ac.uk/opdc/news/latest/new-laboratory-facilities-for-opdc-researchers |
| Description | News article to celebrate building of new laboratory space for OPDC Researchers |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A news article celebrate a major building in the centre of Oxford has been constructed to create a new research centre bringing together cellular neuroscience and physical sciences. Members of the OPDC will move into the new building. Known as the new Kavli Institute for NanoScience Discovery (Kavli INSD), the building will uniquely combine structural biology with world-leading biochemistry, pathology, chemistry, physics, physiology and engineering. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dpag.ox.ac.uk/opdc/news/latest/new-laboratory-space-for-opdc-researchers |
| Description | News article to celebrate research success in World Parkinson's Month April 2020 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | In April 2020, a news article was published to celebrate research success in World Parkinson's Month |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.dementiasplatform.uk/news-and-blogs/news/world-parkinsons-month-frontier |
| Description | News article to promote the Wade-Martins Group achieving Bronze award for sustainable practices |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In October 2021, the Wade-Martins Group achieved a Laboratory Efficiency Assessment Framework (LEAF) Bronze award in recognition of its sustainable practices. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dpag.ox.ac.uk/news/wade-martins-group-achieves-bronze-award-for-sustainable-practices |
| Description | News item: Fellowship awarded to Mootaz Salman could pave the way for early intervention in Parkinson's |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Mootaz Salman has been awarded a Leverhulme Trust Early Career Fellowship - a highly prestigious, fiercely competitive research award with just 145 awards available nationally this year across all disciplines. These fellowships enable early career academics to undertake a significant piece of publishable work. Dr Salman is now pursuing a 3-year research project entitled "Targeting mechanisms of blood-brain barrier dysfunction in Parkinson's using humanized 3D brain-on-a-chip models", on which he will work independently within DPAG in close collaboration with the Wade-Martins Group. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/news/fellowship-awarded-to-mootaz-salman-could-pave-the-way-for-early-inte... |
| Description | News item: Oxford Parkinson's Disease Centre awarded £3.8 million to reveal the role of calcium in Parkinson's |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Researchers at the Oxford Parkinson's Disease Centre led by Professor Richard Wade-Martins with Professor Stephanie Cragg and Professor Peter Magill, have been awarded a £3.8 million Wellcome Trust Collaborative Award in Science to study the critical role of calcium in the biology of dopamine neurons. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/news/opdc-awarded-3-8-million-to-reveal-the-role-of-calcium-in-parkinsons |
| Description | News item: The Wade-Martins Group achieved a Laboratory Efficiency Assessment Framework (LEAF) Silver award in recognition of its sustainable practices. |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The Wade-Martins Group has achieved a Laboratory Efficiency Assessment Framework (LEAF) Silver award in recognition of its sustainable practices. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/news/wade-martins-group-attain-silver-sustainability-award |
| Description | News of a major new $9 million project funded by the Aligning Science Across Parkinson's (ASAP) initiative |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | In October 2021, it was announced that a major new $9 million project funded by the Aligning Science Across Parkinson's (ASAP) initiative will map the original circuits vulnerable to Parkinson's on an unprecedented scale. The project is a collaboration between core investigators Stephanie Cragg, Richard Wade-Martins, and Peter Magill at Oxford, Mark Howe at Boston University and Dinos Meletis at the Karolinska Institutet, as well as collaborators Yulong Li at Peking University and Michael Lin at Stanford University. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.dpag.ox.ac.uk/news/mapping-uncharted-networks-in-the-progression-of-parkinsons |
| Description | News stories to promote a new Oxford specialist centre looking into research and helping people with memory problems |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The Oxford Mail published a news story to promote a new Oxford specialist centre looking into research and helping people with memory problems. Also featured on the University of Oxford website: https://www.neuroscience.ox.ac.uk/news/first-of-its-kind-in-uk-innovative-new-brain-health-centre and on the Oxford Health NHS Foundation Trust website: https://www.oxfordhealth.nhs.uk/news/innovative-new-brain-health-centre-first-of-its-kind-in-uk/ |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.oxfordmail.co.uk/news/18734255.oxford-brain-health-centre-may-game-changer-dementia/ |
| Description | News story about OPDC's Natalie Connor-Robson engagement work on widening access to STEM skills with In2scienceUK |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | OPDC Career Development Fellow Natalie Connor-Robson shares STEM career advice with students taking part in the In2scienceUK programme. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/opdc-s-natalie-connor-robson-widens-access-to-stem-skills-with-in2scienceu... |
| Description | News story about a collaborative study led by the OPDC's Dr Nora Bengoa-Vergniory |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | News story about a collaborative study led by the OPDC's Dr Nora Bengoa-Vergniory that has shown that compounds known as molecular tweezers could become a promising disease modifying therapy for Parkinson's. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/tiny-brain-tweezers-could-hold-the-key-to-treat-parkinson-s |
| Description | News story and video featuring the Wade-Martins lab to mark World Parkinson's Day |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | News story to mark World Parkinson's Day, featuring a video with an inside look into the Wade-Martins Laboratory. The Wade-Martins Group conducts critical research into several neurodegenerative diseases, and makes up part of the OPDC with its work into Parkinson's, with the aim to understand the molecular mechanisms of these disorders and help develop new treatments. This video is narrated by Professor Richard Wade-Martins, with contributions from Charmaine Lang, Dayne Beccano-Kelly, Peter Kilfeather, Phillippa Carling, Gabriela Vilema Enriquez and former members of the team, Gabriele Corda, Rebecca Wallings and Marta Cherubini. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/inside-the-wade-martins-lab |
| Description | News story and video highlighting an OPDC study that has uncovered a new way to target and treat the leading genetic contributor to Parkinson's |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | News story featuring a research paper that has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/opdc-study-uncovers-a-new-way-to-target-and-treat-the-leading-genetic-cont... |
| Description | News story featuring a new study on neurons grown from skin samples reveals key molecular changes in people with Parkinson's |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | News story highlighting a new research paper in Human Molecular Genetics: Cellular a-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/new-opdc-study-on-neurons-grown-from-skin-samples-reveals-key-molecular-ch... |
| Description | News story highlighting Dayne Beccano-Kelly, who shares his experience of being a black professional in academia & the wider story of race in research |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dayne Beccano-Kelly, an electrophysiologist and Career Development Fellow in the Department of Physiology, Anatomy and Genetics, and part of the Oxford Parkinson's Disease Centre (OPDC) spoke to Parkinson's Life about his experience as a black professional working in Parkinson's research. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/opdc-researcher-shares-his-experience-of-being-a-black-professional-in-aca... |
| Description | News story highlighting a new paper to report genome-wide transcriptomic RNA-Seq profiling of stem cell-derived astrocytes from people with Parkinson's & healthy controls. |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The news items highlighted a new research paper that was published to report genome-wide transcriptomic RNA-Seq profiling of stem cell-derived astrocytes from people with Parkinson's & healthy controls. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/new-opdc-research-into-the-role-of-astrocytes-in-parkinson-s-progression |
| Description | News story highlighting a new study which has shown that the key protein RE1 Silencing Transcription Factor (REST) regulates the health of those neurons critically affected in Parkinson's Disease. |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A study led by University of Oxford researchers, Dr Brent Ryan and Dr Nora Bengoa-Vergniory has shown that the key protein RE1 Silencing Transcription Factor (REST) regulates the health of those neurons critically affected in Parkinson's Disease. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.opdc.ox.ac.uk/dopamine-neurons-need-a-rest-in-parkinson-s-disease |
| Description | News story highlighting a study that a novel assay termed the tau-proximity ligation assay is able to recognise Alzheimer's disease before current detection methods. |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A study led by the Oxford Parkinson's Disease Centre's (OPDC) Dr Nora Bengoa-Vergniory has shown that a novel assay termed the tau-proximity ligation assay is able to recognise Alzheimer's disease before current detection methods. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.opdc.ox.ac.uk/tau-proximity-ligation-assay-reveals-extensive-previously-undetected-patho... |
| Description | News story promoting that Milena Cioroch is awarded Apprentice of the Month for March 2020 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Milena Cioroch, Research Assistant in the Wade-Martins Lab at the Oxford Parkinson's Disease Centre, was awarded Apprentice of the Month for March 2020 by her training provider Abingdon and Witney College. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/milena-cioroch-is-awarded-apprentice-of-the-month-for-march-2020 |
| Description | News story promoting that a new study finds mutations in the gene LRRK2 affect normal cell function |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | A new story featured on our website about a new study from OPDC Career Development Fellow Natalie Connor-Robson who has investigated how mutations in the gene LRRK2, which are known to cause Parkinson's, effect normal cell function. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/opdc-study-finds-mutations-in-the-gene-lrrk2-affect-normal-cell-function |
| Description | News story to highlight OPDC Career Development Fellow Dr Dayne Beccano-Kelly has been selected by The World Parkinson Coalition (WPC) to be one of eight Science Ambassadors leading up to the 6th World Parkinson Congress |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | PDC Career Development Fellow Dr Dayne Beccano-Kelly has been selected by The World Parkinson Coalition (WPC) to be one of eight Science Ambassadors leading up to the 6th World Parkinson Congress in June 2022. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/opdc-s-dayne-beccano-kelly-appointed-world-parkinson-coalition-science-amb... |
| Description | News story to highlight OPDC Researchers participating in fundraising for Parkinson's UK |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | On Sunday 26 April, members of the Wade-Martins Group from the Oxford Parkinson's Disease Centre threw themselves into a variety of imaginative challenges for the national 2.6 challenge campaign to raise vital funds for Parkinson's UK. The challenge required participants to dream up an activity based around the numbers 2.6 or 26 that suits their skills and complete it on Sunday 26 April - when the 40th London Marathon would have taken place. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.dpag.ox.ac.uk/news/opdc-researchers-hit-target-for-parkinsons-uk-with-2-6-challenge |
| Description | News story to publicise OxDARE (Prof Clare Mackay) being awarded Department of Psychiatry's Award for Public Engagement and Science Communication |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | In January 2020, the Oxford Dementia and Ageing Research (OxDARE) team were awarded Department of Psychiatry's Award for Public Engagement and Science Communication, 2019. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.psych.ox.ac.uk/news/winners-of-the-2019-department-of-psychiatry-public-engagement-with-... |
| Description | Nora Bengoa-Vergniory article on Celgene Fellowship |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Interviwe with Dr Nora Bengoa-Vergniory on her experience as a Celgene Fellow for the Oxford University Medical Sciences division website |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.medsci.ox.ac.uk/research/internal/funding-directory/oxford-celgene-fellowship/oxford-cel... |
| Description | Numerous social media posts to welcome new lab members |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Over the year, we have sent numerous social media post welcoming new lab members to the research team, and linking to their profiles on our website |
| Year(s) Of Engagement Activity | 2021 |
| Description | OPDC 11 July 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 11 July 2019, Austen Milnerwood, The Neuro, McGill University, gave a talk on 'The Quest for Neuroprotection in Parkinson's disease: reversing synaptic dysfunction'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Facebook Page |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | Creation of OPDC Facebook page. Used to update on OPDC activity. Focus on outreach events, but also includes news about publications etc. Also used boosted posts to promote OPDC open day. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| URL | https://www.facebook.com/OxfordPDCentre/ |
| Description | OPDC Newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | In Septmeber 2019, the OPDC Autumn Newsletter was printed and published online. It included updates on:- our cohort studies from our cohort director Michele Hu, our work using smartphones to monitor Parkinson's progression. a key protein in Parkinson's which is showing promise for drug discovery understanding the genetics of Parkinson's the World Parkinson's Congress, Kyoto. The newsletter also includes a a poem by Maggie Lines and branch news from Parkinson's UK Milton Keynes. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/issue-10-autumn-newsletter-2019.pdf |
| Description | OPDC Newsletter Summer 2017 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | We have produced a 12 page newsletter with updates on our recent activities. This includes OPDC research news, outreach activities and news from members of the cohort and Parkinson's UK. The newsletter is posted to all cohort members and emailed to those on the news mailing list. It is also available online. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.opdc.ox.ac.uk/newsletters |
| Description | OPDC Open Day 2016 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | OPDC Open Day 2016 250 OPDC study Participants and Partners registered for event. Day of talks from Michele Hu, Fahd Baig, Claudio Ruffmann, Tom Barber and Richard Wade-Martins. Discussion of what participants would like from study. Talks filmed and podcasts added to website |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.opdc.ox.ac.uk/openday2016 |
| Description | OPDC Open Day 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | We held an afternoon of talks and invited members of our cohort, their supprters, and members of the Thames Valley Parkinson's UK Excellence Network to attend. Around 200 people registered for the event and the feedback was largey positive. We have moved to a larger venue out of the city centre to allow us to offer parking. Talks were filmed and are available on our website and YouTube channel. Speakers at the event were Michele Hu, Mark Kelly, James Cantley, Tom Barber, Christine Lo, Sally Cowley and Richard Wade-Martins. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.opdc.ox.ac.uk/openday2017 |
| Description | OPDC Open Day talks online |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | A series of talks recorded at the 2018 OPDC Particpant's day are available to view on our YouTube channel and on our website. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.opdc.ox.ac.uk/videos |
| Description | OPDC Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | The OPDC Research Day is a one-day event with research talks from world leading Parkinson's researchers on topics including clinical studies, imaging, genetics, proteomics, neuronal cells and animal models. The 2017 OPDC Research Day was held in the Medical Sciences Teaching Centre, Oxford. There was a full day of talks and poster sessions on Parkinson's research. This one-day event included research talks by national and international keynote speakers and Oxford researchers on a range of Parkinson's work including clinical studies, imaging, genetics, proteomics, neuronal cell culture and animal models. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.opdc.ox.ac.uk/research2017 |
| Description | OPDC Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | We held a research day to present an update on current Parkinson's research in the region and invited members of our SAB from overseas to present their work. This was attended by researchers from accross Oxford as well as members of the local Parkinon's UK group and interested study participants. We invited Hazel Stanyon, a study partiicpants who apoke about her experiences of how exercise has helped her Parkinson's symptoms and shared a poem. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.opdc.ox.ac.uk/research2018 |
| Description | OPDC Seminar 11 February 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 11 February 2022, Louis-Eric Trudeau gave an OPDC Seminar talk, titled, 'Making sense of the exuberant axonal connectivity of dopamine neurones'. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talks.ox.ac.uk/talks/id/df0f906f-bf3d-41ca-b7fb-3026912ce1bf/ |
| Description | OPDC Seminar 12 November 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 12 November 2019, Evrando Fei Fang, University of Oslo, gave a talk on 'NAD+ and Mitophagy in Brain Ageing and Neurodegenerative Disorders'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar 13 November |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 13 November, Jerome Baufreton, Laboratory of Synaptic and Cellular Dynamics of Neuronal Networks, The Neuroscience Institute at Bordeaux, gave a talk on the 'Synaptic alterations in the indirect-pathway of the basal ganglia in experimental Parkinsonism |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar 15 October |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 15 October, Paolo Calabresi, University of Perugia, Italy, gave a talk on the 'Striatal synaptic dysfunction in Parkinson's disease'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar 16 July 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 16 July 2019, Esther Sammler, University of Dundee gave a talk on 'Interrogating LRRK2 kinase pathway in human bio-samples in Parkinson's disease'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar 20 January 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On behalf of Professor Richard Wade-Martins, Dr Matthew LaVoie gave a talk on 'Proteostasis and Mitochondrial Pathways in the Pathogenesis and Treatment of Parkinson's Disease on Monday 20 January 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | OPDC Seminar 20 January 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 20 January 2022, Pietro De Camilli gave an OPDC Seminar talk, titled, 'Intracellular Membrane Lipid Dynamics and Neurodegenerative Diseases'. |
| Year(s) Of Engagement Activity | 2021,2022 |
| URL | https://talks.ox.ac.uk/talks/id/27284d4a-7121-4d63-9c39-fe40f59dd518/ |
| Description | OPDC Seminar 22 November 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 22 November 2021, Dr Michael Henderson gave an OPDC seminar talk titled, 'Modulators of pathology progression in neurodegenerative disease'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/c26bb54d-93e4-406a-80c1-43bcbf11b31e/ |
| Description | OPDC Seminar 26 January 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 26th January 2021, Dr Wilma van de Berg gave an OPDC emianr talk titled, ' Tales from the human brain: a multi scale approach to elucidate pathogenic mechanisms involved in Parkinson's'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.opdc.ox.ac.uk/seminars-events |
| Description | OPDC Seminar 28 October 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 28 October 2019, Ellen Sidransky, National Human Genome Research Institute, NIH, gave a talk on 'The magic in the web of it: How a rare disorder is helping to untangle the mysteries of Parkinson's disease'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar 3 February 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On behalf of Professor Richard Wade-Martins, Dr Michael Ward, National Institute of Neurological Disorders and Stroke, gave a talk on 'Combining iPSCs and 'omics to identify molecular convergence in neurodegenerative disorders' on Monday 3 February 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | OPDC Seminar 8 February 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On *th February 2021, Emmanouil Metzakopian gave an OPDC Seminar talk titled 'CRISPR Cas9 genetic screens to ameliorate cellular stress in neurodegeneration'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.opdc.ox.ac.uk/seminars-events |
| Description | OPDC Seminar 8 March 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr. Nicolas Tritsch (Neuroscience Institute and Marlene & Paulo Fresco Institute for Parkinson's & Movement Disorders, New York University, gave an online OPDC seminar talk titled, Modulation of striatal circuits by midbrain dopamine neurons |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/28ca76e2-e9fa-4ef1-a3c7-d23a9bf39852/ |
| Description | OPDC Seminar 9 March 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On behalf of of Professor Richard Wade-Martins, Dr Hélène Plun-Favreau, UCL Institute of Neurology gave a talk on Mitophagy: from genetics to biology, and back on 9 March |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | OPDC Seminar April 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 16 April 2019, Darren Moore, Center for Neurodegenerative Science, Van Andel Research Institute, gave a talk on the 'Pathway to Parkinson's Disease: A Tale of Two Genes'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar April 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 20 April, Professor Daniel Otzen. Interdisciplinary Nanoscience Center (iNANO), Aarhus University will give a talk on the 'Targeting cytotoxic alpha-synuclein oligomers in Parkinson's Disease'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/professor-daniel-otzen-20-04-20 |
| Description | OPDC Seminar June 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 12 June 2019, Sonia Gandhi, UCL Queen Square Institute of Neurology, gave a a talk on 'The toxic consequences of protein aggregation in Parkinson's disease'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar May 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 14 May 2019, Mart Saarma, University of Helsinki, gave a talk on the 'Unconventional Endoplasmic Reticulum Located Trophic Factor for Parkinson's Disease'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar September 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 17 September 2019, Michael Coleman, Department of Clinical Neurosciences, University of Cambridge, gave a talk in the 'Mechanisms of axon degeneration in injury and disease'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC Seminar held on 18 May 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 18 May 2022, Dr Nicole Calakos (Dept. of Neurology, Duke University, School of Medicine), gave an OPDC seminar talk titled, A hidden regulator of neuromodulation and motor learning: Protein synthesis by the integrated stress response (ISR) |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talks.ox.ac.uk/talks/id/d3183e00-517f-418f-be8c-3150129c7230/ |
| Description | OPDC Seminar held on 22 June 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 22 June 2021, Dr Olga Corti gave an OPDC seminar titled, Mitophagy dysfunction in autosomal recessive Parkinson's disease: is it the whole story? |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/02973f03-653d-41da-bedf-cfedb5e8b829/ |
| Description | OPDC Seminar held on 24 May 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 26 May 2022, Dr Kevin McFarthing (Research Advisor, Parkinson's UK Oxford Branch) gave an in person OPDC seminar talk titled, 'The drug development landscape in Parkinson's'. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talks.ox.ac.uk/talks/id/11a186f0-d507-49db-8355-9f6aa08ebcae/ |
| Description | OPDC Seminar held on 25 January 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 25 January 2023, Dr. Daniela Berg, (University Medical Center Schleswig-Holstein, Germany) gave an online OPDC seminar talk titled, 'Prodromal PD-definition and impact for clinical studies'. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://talks.ox.ac.uk/talks/id/88329935-b48d-4ff8-b8bf-e69f60fadc04/ |
| Description | OPDC Seminar held on 27 February 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 27 February 2023, Professor Malú Gámez Tansey (University of Florida) will give an OPDC seminar talk - title tbc. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://talks.ox.ac.uk/talks/persons/id/3d3d9b0c-14b6-4ef5-9734-30c1a3e3d2b6 |
| Description | OPDC Seminar held on 27 June 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 27 June, Dr. Mark R. Cookson (Laboratory of Neurogenetics, National Institute on Aging (NIA)) gave an OPDC seminar talk titled, 'The role of LRRK2 in familial and sporadic Parkinson's disease. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talks.ox.ac.uk/talks/id/c248cab1-6fb4-45ee-a14d-1e53d3eb1b2f/ |
| Description | OPDC Seminar held on 30 March 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 30 March 2023, Professor Pascal Kaeser (Harvard Medical School) will give an OPDC online seminar talk titled, 'Mechanisms and Roles of Fast Dopamine Signaling'. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://talks.ox.ac.uk/talks/id/e623ef3c-aff1-4117-852e-93500d350276/ |
| Description | OPDC Seminar held on 31 October 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 31 October 2022, Suzanne Pfeffer, Ph.D. (Stanford University School of Medicine) gave an online OPDC seminar talk titled, 'LRRK2 kinase in Parkinson's disease: from single molecule to the brain'. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talks.ox.ac.uk/talks/id/161e8a60-d515-4545-9ade-3f89b3413b00/ |
| Description | OPDC Seminar held on 6 July 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 6 July 2021, Dr Mark Howe gave an OPDC seminar talk titled, 'Sub-second Striatum Neuromodulatory Signaling on Multiple Spatial Scales During Learning and Action'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/da6b9878-7df5-47b2-98f3-0e1cb10ee3ac/ |
| Description | OPDC Seminar held on 6 July 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 6 July 2022, Dr Clemens Scherzer (Harvard Medical School) gave an online OPDC seminar talk titled, 'Cell circuits, progression genetics, and the quest to solve Parkinson's with precision medicine'. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://talks.ox.ac.uk/talks/id/308dacef-951d-4fbb-980f-af68c03dd0ed/ |
| Description | OPDC Seminar held on 7 December 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 7 December 2021, Dinos Meletis gave an OPDC seminar talk titled, 'Molecular and functional organization of the mouse striatum'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/9ab779f8-edc6-4043-adf2-e9a82a04aa5e/ |
| Description | OPDC YouTube channel |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Creation of OPDC YouTube channel to collate our podcasts etc. 32 subscribers, >2,860 views Feb 2016-Jan 2017. 2016 talks >1,450 views, 2016 OPDC highlights video >350 views, 2015 talks >1,000 views |
| Year(s) Of Engagement Activity | 2015,2016 |
| URL | http://www.youtube.com/channel/UCGzboizARwaAUFW5FjPmmZw |
| Description | OPDC newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | Issue 9 of the OPDC Newsletter was printed and published online. The newsletter give an important update on all our research activities. Our Winter 2018/19 newsletter included an update on our cohort studies, a new study to look at sleep in the home, and an update on our work using smartphones to monitor Parkinson's progression. Our statistician has been working to define new subsets of Parkinson's and our brain imaging research finds links between apathy and REM Sleep Behaviour Disorder (RBD). There is also news on how we have used skin cells donated by cohort members to derive dopamine neurons in our labs and used these to study how one common variant in genetics can increase the risk of sporadic Parkinson's. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc2018-19-newsletter.pdf |
| Description | OPDC newsletter |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | In March 2022, the OPDC newsletter was circulated in hard copy and online. The Spring 2022 newsletter included: Updates from the discovery team on the UPP project, Introducing the Central Oxford Cohort Team, News for research participants, OPDC team update, Parkinson's UK walk, New laboratory facilities, Current OPDC research work and findings, Two major new Grants and Giving to OPDC |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/files/research/opdc-newsletter-march-2022 |
| Description | OPDC researchers welcome Parkinson's UK and the Oxford Branch committee |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In March 2022, the Oxford Parkinson's Disease Centre (OPDC) hosted Caroline Rassell, Parkinson's UK Chief Executive; David Dexter, Associate Research Director; Trustee Board members, Gary Shaughnessy (Chair) and Sally Bromley; together with members of the Parkinson's UK Oxford Branch committee, for a visit to showcase the research being carried out in Oxford. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/opdc/news/latest/opdc-researchers-welcome-parkinson2019s-uk-and-the-oxford... |
| Description | OPDC seminar Feb 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 13 February Elisa Greggio, Department of Biology, University of Padova, gave a seminar talk on the 'Molecular pathways to Parkinson's disease: more than neurons?' |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC seminar March 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 27 March 2019, Kirsten Harvey, UCL School of Pharmacy, gave a talk on the 'LRRK2 Mediated Cellular Function from Vesicular Trafficking to Gene Expression'. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/2019-seminar-series.pdf |
| Description | OPDC welcomes Participants to Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Study participants or study members |
| Results and Impact | On September 10th, 2018 over 200 members of Discovery cohort came to the Jury's Inn, Oxford to hear about our latest research and share their views. We would like to thank all of the cohort members who came to the event from our centres across the country, and joined in the lively discussion session. Researchers from across OPDC's themes shared their work. These included talks on our work to develop a new test for Parkinson's, how we are using skin biopsy samples from our cohort to look for new potential therapies and new drugs trials on our horizon, our work to improve sleep studies, how we are working with other large studies of people with Parkinson's to better define Parkinson's and our work on dyskinesia. We also heard about a new survey to define top priorities for Parkinson's research and heard more about the brain donation process. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.opdc.ox.ac.uk/opdc-welcomes-participants-to-open-day |
| Description | On-line collaboration tool |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In support of the broader collaboration aims of the UKCRIS programme, an online portal has been designed and launched to facilitate programme partners ability to share research interests and provide opportunities for virtual forums enabling pre research collaboration together with private workspace for collaboration projects to be progressed. Additionally the site provides a facility for the general public to be aware of research activities in the fields of mental health and dementias. |
| Year(s) Of Engagement Activity | 2016,2017 |
| URL | https://crisnetwork.co |
| Description | Online OPDC Seminar 10 December |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 10 December, Richard Youle, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA, gave an online talk 'Mechanisms of Innate Immunity and Parkinson's Disease'. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Online OPDC Seminar 12 October 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 12 October 2021, Dr Sreeganga Chandra gave an OPDC Seminar talk titled. 'Synaptic Vesicle Endocytosis and Parkinson's disease'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/043b029a-b6e5-4f8a-bd85-1bff8906b38d/ |
| Description | Online OPDC Seminar 13 October |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 13 October, D. James Surmeier, Feinberg School of Medicine at Northwestern University, USA, gave an online talk on the 'Time to revise the classical model of basal ganglia dysfunction in PD: New insights from a novel, progressive mouse of mitochondrial complex I dysfunction'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 15 June |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 15 June, Tim Bartels, UK Dementia Research Institute (DRI), University College London (UCL) gave an online talk on the 'Selective brain region vulnerability in Parkinson's Disease is governed by a-Synuclein conformations'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 17 May 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 17 May 2021, Dr. Per Borghammer gave an OPDC seminar talk titled, 'Body-first & Brain-first Parkinson's disease - explaining motor asymmetry, non-motor subtypes, and dementia'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/055dec13-1a48-4068-94ee-ceb9b65ac2a5/ |
| Description | Online OPDC Seminar 18 May |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 18 May, Vincenzo Bonifati, Erasmus University Medical Center, Rotterdam, gave an online talk with 'An update on the quest for genetic determinants in Parkinson's Disease'. & related diseases |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 19 April 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | On 19 APril 2021, Dr Anne Grünewald, Associate Professor at the University of Luxembourg gave an online OPDC seminar talk titled, 'Mitochondrial DNA at the interface between mitochondrial dysfunction and inflammation in Parkinson's disease'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/f8696cd5-aa1c-4e2c-ada5-a4c08976364b/ |
| Description | Online OPDC Seminar 20 April |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 20 April, Daniel Otzen, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, gave an online talk on the 'Targeting cytotoxic alpha-synuclein oligomers in Parkinson's Disease' |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 22 September |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 22 September, Jacqueline Burré, Brain and Mind Research Institute at Weill Cornell Medicine, USA gave an online talk on 'Function and Dysfunction of Synucleins - Membranes Matter'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 6 July |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 6 July, Madeline Lancaster, MRC, Laboratory of Molecular Biology, Cambridge, gave an online talk on 'Exploring human brain structure and function using cerebral organoids'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar 9 March 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 9 March, 2021,Dr Nicolas Tritsch, Neuroscience Institute and Marlene & Paulo Fresco Institute for Parkinson's & Movement Disorders, New York University. gave an online talk 'Modulation of striatal circuits by midbrain dopamine neurons' |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.opdc.ox.ac.uk/seminars-events |
| Description | Online OPDC Seminar 9 November |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 9 November, Valina Dawson, John Hopkins University School of Medicine, Baltimore, Maryland, USA gave an online talk 'Decoding Parkinson's Disease: New Therapeutic Opportunities'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/_asset/file/opdc-seminars-2020.pdf |
| Description | Online OPDC Seminar on 22 September 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 22 September 2021, David Rubinsztein gave an OPDC seminar talk, titled, 'Autophagy and neurodegeneration'. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://talks.ox.ac.uk/talks/id/e89c9fb6-1634-45f8-86c0-f43eb5fe22c8/ |
| Description | Oxford Drug Discovery Institute Research Symposium, Oxford UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | In September 2022, Professor Richard Wade-Martins gave a talk at the Oxford Drug Discovery Institute Research Symposium, Oxford UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Oxford Parkinson's Disease Centre pays tribute to one of its loyal fundraisers |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Researchers from the Oxford Parkinson's Disease Centre (OPDC) paid tribute to Bobbie Coelho, one of the OPDC's long term fundraisers who has decided to take a step back from active fundraising activities. A video message was created from OPDC researchers thanking her for all the amazing work she has done towards funding Parkinson's research over the years. Together with a bouquet of flowers, they also gave her an engraved glass OPDC honorary award which was presented to her 'in recognition of outstanding fundraising to support research into Parkinson's'. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.opdc.ox.ac.uk/oxford-parkinson-s-disease-centre-pays-tribute-to-one-of-its-loyal-fundrai... |
| Description | Oxford Parkinson's Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On Tuesday 29th November 2022, Professor Richard Wade-Martins and Professor Michele Hu from the Oxford Parkinson's Disease Centre (OPDC) hosted the Oxford Parkinson's Research Day at the Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford. Professor Irene Tracey, Vice-Chancellor Elect of the University of Oxford, Warden of Merton College and Professor of Anaesthetic Neuroscience, opened the days' proceedings. The programme was split across four sessions covering a wide range of translational work into Parkinson's: "Clinical Research into Parkinson's", "Translational models of Parkinson's", "Molecular Mechanisms and related biomarkers", and "Cellular models and target discovery" describing work across the University and from our collaborators. There were three invited keynote speakers:- Professor Masud Husain, University of Oxford. Masud Husain is Professor of Neurology & Cognitive Neuroscience at the University of Oxford. He leads the Neurological Conditions theme of the NIHR Oxford Biomedical Research Centre and is Editor-in-Chief of the publication, Brain. Together with Cornelia van Duijn, he leads Dementia Research Oxford. Professor Husain's presentation was titled, "When the spark goes out: the neurology of motivation and apathy". Professor Miratul Muqit, University of Dundee. Miratul Muqit is Professor (Clinical) MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee. His laboratory studies the protein kinase, PTEN-induced kinase 1 (PINK1) in which loss of function mutations cause Parkinson's disease. Professor Muqit presented, "Decoding Mitochondrial Damage Response Pathways linked to Parkinson's disease". Professor Sonia Gandhi, UCL. Sonia Gandhi is Professor of Neurology, Clinical and Movement Neurosciences at Queen Square Institute of Neurology, University College London. Professor Gandhi's laboratory works on the cellular and molecular biology of Parkinson's and her talk title was, "Thinking big to see small: from nanoscale to mesoscale resolution in Parkinson's". In addition to the talks, there were 37 poster presentations on display throughout the day. The event closed with Dr Kevin McFarthing, Research Advisor, Parkinson's UK Oxford Branch, presenting the best poster award voted for by all attendees. The prize awarded for the best poster was won by DPhil student Victor (Shijun) Yan, from the Molecular Neurodegeneration Research Group, University of Oxford, for his poster titled, 'a-synuclein in L1CAM-Positive Serum Extracellular Vesicles as a predictive biomarker for Parkinson's disease pathology'. Selected talks included Charmaine Lang, Peter Kilfeather, Sally Cowly, Michael Lawton, Becky Carlyle, George Tofaris, Laura Parkkinen, Katherine Brimblecombe, Ira Milosovic |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dpag.ox.ac.uk/opdc/oxford-parkinson2019s-disease-centre-host-the-2022-oxford-parkinson20... |
| Description | Oxford Science Festival Information Stand |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Oxford Science Festival, June 2016 (Clare MacKay manned a stand) |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.oxfordshiresciencefestival.com/ |
| Description | Oxford Sleep Study #OxfordAI video |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Sleep study on wearable technology chosen by Oxford University team for a feature video as part of their OxfordAI series. Coverage on Oxford University website, twitter and facebook feeds. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.facebook.com/the.university.of.oxford/videos/2136127846704050/ |
| Description | Oxford Sparks'animation about the role of microglia in neurodegeneration |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Postdoc Hazel Roberts won Oxford Sparks' competition to have an animation made about the role of microglia in neurodegeneration. Title: Discovering life-changing dementia treatments. Your beautiful, complex brain is a network of microscopic cells that connect together to form your thoughts and personality, and control your body. The network is fragile and requires constant upkeep, like a garden. The brain has its own gardeners, specialised cells called microglia. In this animation we look at how researchers at the University of Oxford are developing drug treatments for Alzheimer's disease, by harnessing the power of the brain's microglia. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.oxfordsparks.ox.ac.uk/content/discovering-life-changing-dementia-treatments |
| Description | Oxford University article on HDAC4 |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on front page on Oxford University website based on HDAC4 pressrelease from parkinson's UK |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ox.ac.uk/news/2018-11-30-experimental-cancer-drug-shows-promise-parkinson%E2%80%99s |
| Description | Parkinson's Documentary - Kent University |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Richard Wade-Martins interview with Isabelle Miller, a journalist at the University of Kent for a documentary about young people who have Parkinson's (20s-30s). To be produced Mar 2018 ------ A bit more about the documentary: It will be a 15-30 minute long-from television documentary. A lot of people forget that it occurs in young people as well as older people, although less common. I want to educate people on how individual it really is, as well as raise awareness, therefore gaining more support. I also want people to see how a young person adapts their life to the condition. Having Parkinson's at a working age is a whole different challenge compared to those who have it later in life. Some have to stop working, some are determined to continue and be a part of the ever-developing research. I want to show people that, yes, it is difficult to live with Parkinson's, and research into YOPD needs to be funded further, however, I also want to show how people make life their own. It would be an insight into both the struggles and normalities people with Parkinson's face. This is a topic which has light and shade for viewers and will serve a great purpose in informing those who need the information. |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | Parkinson's Life online article on HDAC4 press release |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Article on research paper based on press relelase from Parkinson's UK |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://parkinsonslife.eu/repurposed-cancer-drug-parkinsons/ |
| Description | Parkinson's Oxford Walk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Supporters |
| Results and Impact | Members of OPDC took part in Parkinson's UK Oxford Walk. OPDC also hosted an information stand at the event. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.parkinsons.org.uk/events/walk-parkinsons-oxford |
| Description | Parkinson's UK Blog Post on HDAC paper |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Blog by Claire bale on Parkinson's UK Blog Using brain cells grown from skin to find new potential drugs Researchers in Oxford are using pioneering stem cell techniques to understand the earliest problems that occur inside brain cells in Parkinson's - and hunt down new drugs that can tackle them. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://medium.com/parkinsons-uk/using-brain-cells-grown-from-skin-to-find-new-potential-drugs-78f56... |
| Description | Parkinson's UK Oxford Walk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | On 22 September, Professor Richard Wade-Martins & Dr Laura Parkinnen took part in the Parkinson's UK Oxford Walk. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Parkinson's Walk 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Members of OPDC took part in the Oxford Parkinson's Walk. Melanie Witt and Jane Rumbold manned an information stand with literature about our work and sign up sheets for infomration about participating in research. Taking part were Michele Hu, Richard Wade-Martins, Sally Cowley, Paul Bolam, Amandine Louvel, Tom Barber, Ludovica Griffanti, Marie Crabbe, ChristineLo, Johannes Klein, Jane Rumbold, Charmaine Lang and Rebecca Wallings. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.opdc.ox.ac.uk/opdc-joins-parkinson-s-uk-2017-oxford-walk |
| Description | Parkinson's public awareness talk at Green Templeton College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | On 11 September 2019, Professor Wade-Martins gave a public awareness talk about Parkinson's Disease at Green Templeton College |
| Year(s) Of Engagement Activity | 2019 |
| Description | Participation in the online Wellcome Centre for Integrative Neuroimaging (WIN) BrainLink event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | On Saturday 26 September 2020, Prof Clare Mackay took part in the online Wellcome Centre for Integrative Neuroimaging (WIN) BrainLink event |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.eventbrite.co.uk/e/brain-link-building-better-brain-research-tickets-119402354657# |
| Description | Pete Magill welcomes Lord O'Shaughnessy, Parliamentary Under-Secretary of State for Health to OPDC & MRC BDNU |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The Medical Research Council Brain Network Dynamics Unit at the University of Oxford recently welcomed Lord James O'Shaughnessy, Parliamentary Under-Secretary of State for Health, for a site visit organised as part of The Royal Society's Pairing Scheme that OPDC theme 3 co-lead Professor Pete Magill is taking part in. The visit began with Unit Group Leaders Peter Brown, Peter Magill and Tim Denison highlighting why, how and where the Unit undertakes its cross-disciplinary research incorporating experimental neuroscience, clinical studies and bioengineering. This prompted some insightful discussion on the Unit's contribution to the UK's research and innovation landscape, as well as its alignment with government policy and strategy. Lord O'Shaughnessy then toured Unit facilities, and met with some of the Unit's early-career scientists who showcased the concepts and technologies underpinning their respective experiments. After lunch, Lord O'Shaughnessy visited Unit research collaborators at the Oxford Parkinson's Disease Centre and the ARUK Oxford Drug Discovery Institute. Peter Magill commented, "Lord O'Shaughnessy's visit was an invaluable opportunity for us to engage and to be engaged. The mutual exchange of knowledge was both invigorating and enlightening. I can highly recommend the Pairing Scheme to other scientists and policymakers." |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.opdc.ox.ac.uk/pete-magill-welcomes-lord-o-shaughnessy |
| Description | Pint of Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave a talk in a pub about the use of stem cells in dementia research |
| Year(s) Of Engagement Activity | 2015 |
| Description | Poster and flash talk at the International Ataxia Research Conference (AIRC) November 19 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Conference abstract, poster presentation, "A CRISPR/Cas9 genome-wide screen identify DDX6 as a novel regulator of FXN expression in Friedreich's ataxia", International Ataxia Research Conference 2019, Washington D.C, United States. Attended by Gabriela Vilema Enríquez & Professor Richard Wade-Martins |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://iarc2019.org/ |
| Description | Poster at Advances in Neurodegenerative Disease Research and Therapy/New Frontiers in Neuroinflammation Keystone Conference, Colorado USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Nora Bengoa-Vergniory poster "Tau-proximity ligation assay detects pathology ahead of tau neurofibrillary tangles in Alzheimer's disease" As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer's disease (AD), Parkinson's disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.keystonesymposia.org/18Z3 |
| Description | Poster presentations at the Dementia Research Day hosted by the ARUK Thames Valley Network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 1st July 2022, members of the Wade-Martins ab presented posters at the 2022 Dementia Research Day hosed by the ARUK Thames Valley network. They included Tara Diviney, Jack Connor, Naroa Ibarra Aizpurua, Remya Nair, Kaitlyn Cramb, Ajantha Abey, Elena Britti, and Sarah Franks. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster presentations at the Oxford Parkinson's Research Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 29th November 2022, members of the Wade-Martins ab presented posters at the Oxford Parkinson's Research Day. They included Naroa Ibarra Aizpurua, Mahmoud Bassal, Elena Britti, Sarah Franks, Quyen Do, Ajantha Abey, Helle Begetofte, Tara Diviney, Remya Nair, William McGuinness, Rachel Heon Roberts, Kaitlyn Cramb, Maria Claudia Caiazza, Elliot Mock, Peter Kilfeather and Hugo Fernandes. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at the British Pharmacological Society Annual Conference, Online meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In October 2020, Prof. Richard Wade-Martins gave a presentation at the British Pharmacological Society Annual Conference. Online meeting |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bps.ac.uk/news-events/news |
| Description | Presentation at the conference; Grand Challenges in Parkinson's Disease, Van Andel Institute, Grand Rapids, MI |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | In October 2021, Prof. Ricahrd Wade-Martins will be giving a presentation at the conference; Grand Challenges in Parkinson's Disease, Van Andel Institute, Grand Rapids, MI |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://grandchallengesinpd.org/ |
| Description | Presentation on Ageing Research for A-Level students at the UNIQ Summer School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Presentation on Ageing Research for A-Level students at the UNIQ Summer School - https://www.psych.ox.ac.uk/team/naiara-demnitz |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.uniq.ox.ac.uk/ |
| Description | Presentation poster session at ADPD in Barcelona in March |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Maria Claudia Caiazza will be presenting her data in a poster session at the AD/PD conference in Barcelona between 15-20th March. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://adpd.kenes.com/ |
| Description | Presented a poster titled, 'TPC2 Expression and Function in Models of Parkinson's disease' at the Oxford Neuroscience Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | In March 2023, Johanna Hoffman presented a poster titled, 'TPC2 Expression and Function in Models of Parkinson's disease' at the Oxford Neuroscience Symposium. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.neuroscience.ox.ac.uk/about/oxford-neuroscience-symposium |
| Description | Presented a poster titled, 'TPC2 Expression and Function in Models of Parkinson's disease' at the Parkinson's Disease ECR UKDRI Manchester conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | In March 2023, Johanna Hoffman presented a poster titled, 'TPC2 Expression and Function in Models of Parkinson's disease' at the first in-person Parkinson's disease Early Career Researcher (ECR) meeting at the Core Technology Facility, University of Manchester. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Primary School Tours of FMRIB Scanner |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Primary schools invited onto tours of the Oxford Centre for Functional MRI of the Brain (FMRIB). |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.oum.ox.ac.uk/braindiaries/ |
| Description | Prof Clare Mackay took part in the online Oxford Health HealthFest |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof. Clare Mackay took part in the online Oxford Health HealthFest on 12th Sept 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.oxfordhealth.nhs.uk/healthfest/ |
| Description | Prof Clare Mackay was involved in producing a newsletter with COVID guidance for older adults |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Clare Mackay was involved in producing a newsletter with COVID guidance for older adults |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.oxdare.ox.ac.uk/_asset/file/covid-19-guidance-for-older-adults-and-their-families.pdf |
| Description | Prof Michele Hu gave a talk, "Developing a Polymodal Imaging Biomarker for Prodromal Parkinson's," Grand Challenges in Parkinson's Disease: When and How does Parkinson's start? at the Van Andel Institute, Grand Rapids, USA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Michele Hu gave a talk, "Developing a Polymodal Imaging Biomarker for Prodromal Parkinson's," Grand Challenges in Parkinson's Disease: When and How does Parkinson's start? at the Van Andel Institute, Grand Rapids, USA |
| Year(s) Of Engagement Activity | 2020 |
| Description | Prof Michele Hu gave a virtual talk on the 04.09.20 to the Parkinson's Progression Markers Initiative (PPMI) Biologics Working Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On 4th September, Prof Michele Hu gave a virtual talk on the "PD subtyping and related biomarkers" to the Parkinson's Progression Markers Initiative (PPMI) Biologics Working Group. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.ppmi-info.org/about-ppmi/who-we-are/working-groups-and-committees/ |
| Description | Prof Michele Hu gave an online talk at the Michael J Fox Foundation webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | On 21 January 2021, Prof Michele Hu gave a talk a |