A randomised placebo-controlled trial of immunotherapy in patients with psychosis associated with anti-neuronal membrane antibodies (SINAPPS 2)
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Neurosciences
Abstract
BACKGROUND
Psychosis is, according to the NHS website, "a mental health problem that causes people to perceive or interpret things differently from those around them. This might involve hallucinations or delusions." Psychosis and schizophrenia are common disorders which hinder people from flourishing, just as they are embarking on life as an adult. These disorders also cost the UK £12 billion per annum. Psychosis has many causes. Recently, we discovered that 5-10% of people with psychosis have antibodies in the blood that are capable of targeting receptors on the surface of brain cells. These receptors are either the "NMDA receptor" or "voltage gated potassium channel complex". The binding of antibodies to these receptors stops them from working properly, which in turn upsets normal brain function.
OUR IDEA
This proposal is based on the idea that the antibodies we find in the blood of people with psychosis are actually causing the problem. This means that we think these people have a basic problem with their immune system, and that the immune system is preventing their brain from working properly. So, in their particular case, psychosis is an "autoimmune disease".
OUR PROPOSAL
We will test this idea by getting eliminating these antibodies in their blood, and see whether this has a useful effect on psychosis symptoms.
THE PLAN
There are three stages to our proposal. (1) First of all, we need to find people with psychosis and antibodies in their blood. This involves testing the blood of around 2460 people with psychosis, over 3 years. To do this, we have set up several centres around England in which there are neurologists and psychiatrists interested in answering the question. We will employ research nurses to work from the centres, seeing as many people with psychosis as possible. Assisting them will be mental health nurses, working in the local trust, as well as an independent mental health advocate. This should identify around 160 people with antibody-associated psychosis, of which we estimate half will be interested in taking part in our trial. (2) Secondly, we will do a "randomised controlled trial" in which 80 people with psychosis and antibodies in their blood are randomly allocated to receive placebo or active immune treatment, alongside their antipsychotic drugs. For immune treatment, we propose people have "intravenous immunoglobulin" (IVIG) for four days, followed by two infusions of "rituximab".
THE TREATMENTS
- Intravenous Immunoglobulin is a blood product. Once the red cells have been removed from blood, the remaining "serum" is collected. Antibodies in the serum are extracted and then pooled together from many hundreds of individuals.
- Rituximab is a drug that causes long-lasting reduction in the "B cells" that are part of the immune system. It is used in many autoimmune diseases, like lupus and rheumatoid arthritis.
- All people in the trial can take normal antipsychotic drugs.
Psychosis is, according to the NHS website, "a mental health problem that causes people to perceive or interpret things differently from those around them. This might involve hallucinations or delusions." Psychosis and schizophrenia are common disorders which hinder people from flourishing, just as they are embarking on life as an adult. These disorders also cost the UK £12 billion per annum. Psychosis has many causes. Recently, we discovered that 5-10% of people with psychosis have antibodies in the blood that are capable of targeting receptors on the surface of brain cells. These receptors are either the "NMDA receptor" or "voltage gated potassium channel complex". The binding of antibodies to these receptors stops them from working properly, which in turn upsets normal brain function.
OUR IDEA
This proposal is based on the idea that the antibodies we find in the blood of people with psychosis are actually causing the problem. This means that we think these people have a basic problem with their immune system, and that the immune system is preventing their brain from working properly. So, in their particular case, psychosis is an "autoimmune disease".
OUR PROPOSAL
We will test this idea by getting eliminating these antibodies in their blood, and see whether this has a useful effect on psychosis symptoms.
THE PLAN
There are three stages to our proposal. (1) First of all, we need to find people with psychosis and antibodies in their blood. This involves testing the blood of around 2460 people with psychosis, over 3 years. To do this, we have set up several centres around England in which there are neurologists and psychiatrists interested in answering the question. We will employ research nurses to work from the centres, seeing as many people with psychosis as possible. Assisting them will be mental health nurses, working in the local trust, as well as an independent mental health advocate. This should identify around 160 people with antibody-associated psychosis, of which we estimate half will be interested in taking part in our trial. (2) Secondly, we will do a "randomised controlled trial" in which 80 people with psychosis and antibodies in their blood are randomly allocated to receive placebo or active immune treatment, alongside their antipsychotic drugs. For immune treatment, we propose people have "intravenous immunoglobulin" (IVIG) for four days, followed by two infusions of "rituximab".
THE TREATMENTS
- Intravenous Immunoglobulin is a blood product. Once the red cells have been removed from blood, the remaining "serum" is collected. Antibodies in the serum are extracted and then pooled together from many hundreds of individuals.
- Rituximab is a drug that causes long-lasting reduction in the "B cells" that are part of the immune system. It is used in many autoimmune diseases, like lupus and rheumatoid arthritis.
- All people in the trial can take normal antipsychotic drugs.
Technical Summary
In three separate studies, we found 6-7% of patients with first-episode psychosis had autoantibodies to the N-methyl D-aspartate receptor or the voltage gated potassium channel complex, at high concentration: 3/46 patients in our initial study (Zandi et al., 2011), 14/230 in the MRC-funded PPiP1 study and 3/59 in PPiP2. We have also shown that 2/3 with high antibody levels are resistant to antipsychotics but respond well to immunotherapy (Zandi et al., 2014).
We propose a randomised double-blind placebo-controlled trial of immunotherapy as add-on to standard anti-psychotic treatment of antibody-associated psychosis, widening the inclusion criteria to improve recruitment to either first episode psychosis or in relapse.
Screening c. 2460 patients with psychosis to identify 160 suitable patients with associated autoantibodies, we shall recruit 80 patients into the trial, following each for 12 months. The primary outcome is time to remission of psychosis, sustained over 6 months (Andreasen et al., 2005). We estimate 20% of placebo-treated participants will achieve this endpoint at one year and that, having discussed with our patient partners, a meaningful treatment effect would be sustained remission in 50%. This can be detected at 80% power with a one-sided p=0.05 with n= 80, allowing for 24 drop outs.
A network of neurologists and psychiatrists at 6 sites (Oxford, Cambridge, Birmingham, Nottingham, Southampton and Manchester) are already testing the feasibility of recruitment and immunotherapy of this challenging patient group in the SINAPPS1 study funded by the Stanley Medical Research Institute (Sec 6.8). Now, SINAPPS2 will randomise patients to receive IVIG (2g/kg over 4 days) followed by two rituximab infusions over the next six weeks. Samples collected in this study from people with acute psychosis will be a substantial resource for later discovery science. This study has profound implications for the understanding and management of psychosis.
We propose a randomised double-blind placebo-controlled trial of immunotherapy as add-on to standard anti-psychotic treatment of antibody-associated psychosis, widening the inclusion criteria to improve recruitment to either first episode psychosis or in relapse.
Screening c. 2460 patients with psychosis to identify 160 suitable patients with associated autoantibodies, we shall recruit 80 patients into the trial, following each for 12 months. The primary outcome is time to remission of psychosis, sustained over 6 months (Andreasen et al., 2005). We estimate 20% of placebo-treated participants will achieve this endpoint at one year and that, having discussed with our patient partners, a meaningful treatment effect would be sustained remission in 50%. This can be detected at 80% power with a one-sided p=0.05 with n= 80, allowing for 24 drop outs.
A network of neurologists and psychiatrists at 6 sites (Oxford, Cambridge, Birmingham, Nottingham, Southampton and Manchester) are already testing the feasibility of recruitment and immunotherapy of this challenging patient group in the SINAPPS1 study funded by the Stanley Medical Research Institute (Sec 6.8). Now, SINAPPS2 will randomise patients to receive IVIG (2g/kg over 4 days) followed by two rituximab infusions over the next six weeks. Samples collected in this study from people with acute psychosis will be a substantial resource for later discovery science. This study has profound implications for the understanding and management of psychosis.
Planned Impact
As well as patients with psychosis, and researchers into psychosis, the following people may benefit from this research: (1) manufacturers of intravenous immunoglobulin may see an increase in its use; (2) manufacturers of assays the neuronal membrane antibodies, such as the anti NMDA receptor antibody; (3) charities and government agencies seeking to improve funding for mental health research may benefit from the paradigm shift in treating psychosis that this work would bring; (4) the implications of a treatable form of psychosis, using immunotherapy, would be a challenge to international healthcare workers and their agencies; (5) the wider public would benefit by learning about the biological nature of psychosis, and hence, hopefully, removing some of the stigma around mental illness.
This work has the capacity to contribute to the nation's health by enhancing the quality of life of a subgroup of people with psychosis. This, in turn, will reduce the economic cost of caring for people with psychosis. It is realistic to imagine that, if this trial is positive, it will have fairly rapid implementation, as all of the required tools (antibody assay kits and therapies) are already available on the NHS. Staff working on this project will develop the skills required to integrate neurology and psychiatric services, which remains a significant obstacle in the delivery of effective healthcare across these disciplines.
This work has the capacity to contribute to the nation's health by enhancing the quality of life of a subgroup of people with psychosis. This, in turn, will reduce the economic cost of caring for people with psychosis. It is realistic to imagine that, if this trial is positive, it will have fairly rapid implementation, as all of the required tools (antibody assay kits and therapies) are already available on the NHS. Staff working on this project will develop the skills required to integrate neurology and psychiatric services, which remains a significant obstacle in the delivery of effective healthcare across these disciplines.
Publications
Al-Diwani A
(2019)
The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data.
in The lancet. Psychiatry
Al-Diwani A
(2017)
Synaptic and Neuronal Autoantibody-Associated Psychiatric Syndromes: Controversies and Hypotheses
in Frontiers in Psychiatry
Al-Diwani AA
(2018)
Neuroimmunology 2017: making progress over 20 years.
in The lancet. Psychiatry
Al-Diwani AAJ
(2017)
Psychosis: an autoimmune disease?
in Immunology
Behrman S
(2019)
Autoimmune encephalitis in the elderly: who to test and what to test for.
in Evidence-based mental health
Cullen AE
(2021)
Influence of methodological and patient factors on serum NMDAR IgG antibody detection in psychotic disorders: a meta-analysis of cross-sectional and case-control studies.
in The lancet. Psychiatry
Title | Collection of serum from 1500 people with psychosis |
Description | ** this is not a data analysis technique but there as not a n appropraite drop down for this ** We have stored serum from 1500 people with psychosis, to search for novel biomarkers of psychosis and novel autoantibodies. This is available to researchers through applciation to the Scientific Steering Committee, led by Peter Jones [Cambridge] |
Type Of Material | Data analysis technique |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | none yet |
Title | Research data supporting publication "Mindfulness-based programmes for mental health promotion in adults in non-clinical settings: A systematic review and meta-analysis of randomised controlled trials" |
Description | These data were collected and meta-analysed following the methods detailed in the supported publication, which is open access. They were uploaded in two formats (zip folders): as Stata files (dta) with explanatory variable labels, and as csv files with explanatory variable lists (_varlist). Each zip folder includes four data sets: (1) "Outcomes_extracted_from_trials" contains the summary statistics that were extracted from trial records for each outcome, (2) "Data_for_sensitivity_subgroup_analyses" contains information on trial characteristics that were used to run subgroup and sensitivity analyses, (3) "ClusterRCTs_clusters" contains cluster information for those trials that were cluster-randomised, and (4) "Within_study_covariances_estimated_from_Galante_2018" contains the within-study correlations between outcome domains in the Galante 2018 trial that were used to estimate other trials' within-study correlations for the multivariate meta-analysis. |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://www.repository.cam.ac.uk/handle/1810/315125 |
Description | Partnership for SINAPPS2 |
Organisation | University of Oxford |
Department | Department of Psychiatry |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Together, we run the SINAPPS2 trial |
Collaborator Contribution | Together, we run the SINAPPS2 trial |
Impact | Together we succeeded in gaining funding for the SINAPPS2 trial |
Start Year | 2016 |
Description | Partnership with the McPin Foundation |
Organisation | McPin Foundation |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | We are investigating a new treatement for psychosis, one of the priorities of the Mc POin foundation's work. |
Collaborator Contribution | The McPin Foundation provides expert advice, support and advocacy of our trial from Mental Health service users. |
Impact | A patient information leaflet on antibody-assocaited psychosis |
Start Year | 2016 |
Title | This study is a trial of IVIG and rituximab |
Description | This is an ongoing trial of two repurposed drugs |
Type | Therapeutic Intervention - Drug |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2023 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | We await impact |
Description | A talk or presentation - PPiP2 & SINAPPS training for researchers from multiple trusts by Brendan Sargent |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation to Research Team encouraging participation and recruitment by research/clinical staff |
Year(s) Of Engagement Activity | 2024 |
Description | Attendance and presentation at Avon and Wiltshire Mental Health Partnership Trust research conference (JV and IC) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Information stand and presentation/breakout session at the AWP Research Matters 2020 conference. The them of the day was 'Imapct'. Presentation given on PPIP2 and SINAPPS2 and a question and answer session held after. Through out the day RA's Jessica and Iona were present at the stand engaging with delegates and distributing promotional materials. |
Year(s) Of Engagement Activity | 2020 |
Description | Attendance at LEAP Meeting, McPin Foundation |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | SINAPPS2 Lived Experience Advisory Panel (LEAP) Meeting attended by McPin Foundation and trial co-PI Thomas Kabir, 3 members of trial team (KY, IC , IH) and patient representatives on Panel. |
Year(s) Of Engagement Activity | 2021 |
Description | Autoantibodies encephalitis |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Royal College of Psychiatrists Faculty of Liaison Psychiatry Annual Residential Conference 'Integrated Psychological Medicine' 11 May 2016 Holiday Inn City Centre, Birmingham - Talk on Autoantibodies encephalitis |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.rcpsych.ac.uk/pdf/CALC_Liaison%20Faculty%202016prog3March.pdf |
Description | BBC Ideas short film |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | participated in a short film for the series BBC Ideas, titled 'Could psychosis be an autoimmune disease?' which covered the background to the SINAPPS2 trial, and the study design. |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.bbc.com/ideas/videos/could-psychosis-be-an-autoimmune-disease/p05zdl33 |
Description | BBC Radio 4 broadcast an exploration into this new understanding of psychiatric disorders earlier this year: The Inflamed Mind |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC Radio 4 broadcast an exploration into this new understanding of psychiatric disorders earlier this year: The Inflamed Mind. |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/programmes/b07pj2pw |
Description | Cambirdge Psychaitry Department |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Zoom conference for psychaitry trainees and consultants in Easter Region |
Year(s) Of Engagement Activity | 2020 |
Description | Clinical Phenotype of Patients With NMDAR Antibodies |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Clinical Phenotype of Patients With NMDAR Antibodies - a presentation at the 5th Schizophrenia International Research Society Conference on 4th April 2016 |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.schizophreniaconference.org/wp-content/uploads/2016/04/SIRSProgramBook2016.pdf |
Description | Curiosity Carnival Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | SIANPPS2 RA, Sally-Anne Vincent joined this public event and knitted a model of neuron with members of the public during the event. She discussed PPiP2/SINAPPS2 with interested members of the public |
Year(s) Of Engagement Activity | 2018,2019 |
Description | ECNP Neuropsychiatry Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ECNP Neuropsychiatry Meeting, satellite meeting to international conference, invited speakers and development research collaboration |
Year(s) Of Engagement Activity | 2020 |
Description | Educational meeting for SINAPPS-2 investigators |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Educational meeting for SINAPPS-2 investigators |
Year(s) Of Engagement Activity | 2020 |
Description | Encephalitis Conference Poster presentation and data-blitz presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Encephalitis Conference Poster presentation and data-blitz presentation |
Year(s) Of Engagement Activity | 2024 |
Description | Glasgow Neuroscience Talk by Alasdair Coles |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Discussion of autoimmune spchosis with neurologists |
Year(s) Of Engagement Activity | 2022 |
Description | HPFT Consultants training day presentation (GT) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2/SINAPPS2 presentation to senior clinicians working for Hertfordshire Foundation Trust |
Year(s) Of Engagement Activity | 2019 |
Description | ISEN Annual Meeting, San Francisco |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 45 minute presentation on The Clinical Science of Anti-NMDA Receptor Encephalitis at the Brain Stimulation Afternoon Symposium at the ISEN International Society for ECT & Neurostimulation |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.isen-ect.org/sites/default/files/ISEN_Annual_Meeting_&_Course_Brochure_2019_FINAL.pdf |
Description | Leeds and York Partnership NHS Foundation Trust Research Forum |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk title "Autoimmune Psychosis - Fact or Fiction?" |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.leedsandyorkpft.nhs.uk/research/wp-content/uploads/sites/6/2020/10/Annual-Research-Forum... |
Description | Meeting with psychiatrists at Norfolk & Suffolk Partnership NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting with psychiatrists at Norfolk & Suffolk Partnership NHS Foundation Trust re PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Meeting with psychiatrists at Nottingham Partnership NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting with research and clinical staff with Nottingham Partnership NHS Foundation Trust |
Year(s) Of Engagement Activity | 2021 |
Description | Meeting with research and clinical staff at Cornwall Partnership NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting with research and clinical staff with Cornwall Partnership NHS Foundation Trust to discuss PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Meeting with research and clinical staff at Pennine Care NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting with research and clinical staff with Pennine Care NHS Foundation Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | NMDAR Antibody Session, Progress in Mind reports from The 6th Biennial Schizophrenia International Research Society Conference (SIRS) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | NMDAR Antibody Session, Progress in Mind reports from The 6th Biennial Schizophrenia International Research Society Conference (SIRS) |
Year(s) Of Engagement Activity | 2018 |
Description | NSFT Medical Post Graduate Training Day Presentation (GT) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2 and SINAPPS2 presentation to junior and senior psychiatrists across Norfolk and Suffolk Foundation Trust |
Year(s) Of Engagement Activity | 2019 |
Description | Oral presentation at Hearing Voices carers event (Suffolk, UK) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | SINAPPS2 project Manager Ksenija Yeeles and SINAPPS2 RA Giuliano Tomei jointly gave a presentation on SINAPPS2 and PPIP2 studies. Approximately 50 attendees were present. The presentation was met with interested from the audience and numerous questions about rationale for the study and methods were asked. |
Year(s) Of Engagement Activity | 2018 |
Description | Oral presentation at an academic meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 RA, SA Vincent gave a presentation on PPiP2/SINAPPS2 studies to junior & senior psychiatrists, doctors and researchers at an academic meeting organised by 2gether NHS Foundation Trust. |
Year(s) Of Engagement Activity | 2019 |
Description | Organising and Participating in the Autoimmune Psychosis Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 17 academic and clinicians attended the Autoimmune Psychosis Workshop initiating discussions and planning of further research following the SINAPPS2 and PPIP2 studies in related research areas. |
Year(s) Of Engagement Activity | 2023 |
Description | PPiP and SINAPPS2 Presentation at local delivery unit meeting Devon Partnership Trust to all service managers in one locality |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation given to all service managers in one locality for Devon Partnership Trust. Meetings were arranged with individal managers as a result and we have received referrals from new teams. |
Year(s) Of Engagement Activity | 2020 |
Description | PPiP and SINAPPS2 Presentation to North London SpR Group (IH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Approximately 30 attendees at North London SpR Group, presentation of PPiP2 and SINAPPS2 studies. Talk given by RA and local (Trust) researcher attended to encourage referrals to study. |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 & SINAPPS training for junior doctors from multiple trusts by Brendan Sargent |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Training provided for Junior doctors wishing to be involved in research by recruiting participants for PPiP2 |
Year(s) Of Engagement Activity | 2024 |
Description | PPiP2 Presentation at Academic meeting in Gloucester (SAV) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2/SINAPPS2 presentation to junior and senior psychiatrists/doctors and researchers |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 and SINAPPS2 Presentation at PGME (post graduate medical education) Somerset Partnership trust (IC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2 and SINAPPS2 Presentation at PGME (post graduate medical education) Somerset Partnership trust to promote interest in the trial and encourage recruitment |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 and SINAPPS2 Presentation for DPT Liaison Psychiatry team (IC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2 and SINAPPS2 Presentation for DPT Liaison Psychiatry team to encourage recruitment to study |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 and SINAPPS2 Presentation to EIT services Conrwall Foundation Trust (IC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2 and SINAPPS2 Presentation to EIT services Conrwall Foundation Trust to encourage referrals and promote interest in trial |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 and SINAPPS2 Presentation to Exeter and East Devon STEP team (specialist team for early psychosis) (IC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation to specialist team to promote interest and encourage referrals for trial |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 and SINAPPS2 Presentation to North and mid Devon STEP team (specialist team for early psychosis) (IC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2 and SINAPPS2 Presentation to North and mid Devon STEP team (specialist team for early psychosis) to promote interest in the trial and encourage referrals. |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 and SINAPPS2 Presentation to Pennine Care Trust staff at Showcasing event (DS) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Between 80-100 staff members from mental health services across Pennine Care NHS trust attended a showcasing event where I gave a presentation on PPiP2/SINAPPS2 with Q&A and discussion afterwards. This was to raise awareness of the research and promote engagement and encourage referrals. |
Year(s) Of Engagement Activity | 2020 |
Description | PPiP2 and SINAPPS2 Presentation to Trust Trainee Consultants (DS) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presented the studies at Trainee doctors teaching afternoon to promote engagement with the study and encourage referrals. Q&A and discussion followed the presentation. |
Year(s) Of Engagement Activity | 2020 |
Description | PPiP2 and SINAPPS2 Presentation to West Suffolk Early Intervention in Psychosis clinicians (GT) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of PPIP2 and SINAPPS2 to trainee doctors and consultant clinicians to raise awareness of the studies and boost recruitment. |
Year(s) Of Engagement Activity | 2020 |
Description | PPiP2 and SINAPPS2 Presentation to all DPT consultants at MAC (IC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | PPiP2 and SINAPPS2 Presentation to all DPT consultants at MAC to encourage participation and referrals |
Year(s) Of Engagement Activity | 2019 |
Description | PPiP2 and SINAPPS2 presentation at Avon and Wiltshire Mental Health Partnership Trust academic meeting (JV) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of PPIP2 and SINAPPS2 to trainee doctors to raise awareness of the studies and boost recruitment. |
Year(s) Of Engagement Activity | 2020 |
Description | PPiP2 and SINAPPS2 presentation at Gloucestershire Health and Care NHS Foundation Trust academic meeting (JV) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of PPIP2 and SINAPPS2 to trainee doctors to raise awareness of the studies and boost recruitment. |
Year(s) Of Engagement Activity | 2018,2020 |
Description | PPiP2 and SINAPPS2 presentation at newly established research group at Avon and Wiltshire Mental Health Partnership Trust (JV) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of PPIP2 and SINAPPS2 to newly established research group and clinicians in attendance. |
Year(s) Of Engagement Activity | 2020 |
Description | PPiP2 and SINAPPS2 presentation to new trust trainee doctors (DS) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Briefly talked about the studies at Trainee doctors induction following talk from Research and innovation team to promote engagement with the study and encourage referrals. |
Year(s) Of Engagement Activity | 2020 |
Description | Participation in BBC Radio 4 Series: A History of Delusions |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Interview as part of a Radio 4 series by Professor Daniel Freeman, a clinical psychologist and has been researching and treating delusions for the past twenty years. A History of Delusions was broadcast weekdays at 13.45 on BBC Radio 4 from Monday 3 December to Friday 14 December 2018 |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.bbc.co.uk/programmes/m0001d95/episodes/player |
Description | Participation in a television programme on BBC Two - Trust Me, I'm a Doctor. A special programme focussing on Mental Health |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | In the relevant section of the TV programme - "Could some mental health conditions be caused by an immune malfunction" I explained that some patients who exhibit classic symptoms of psychosis may not actually have a psychiatric condition, but a rare form of encephalitis and that the biological cause for this condition is now increasingly recognized by psychiatrists and neurosurgeons. Patients have been successfully treated with immunotherapy, which removes the rogue antibodies from the patient's blood. This treatment has led to patients making a dramatic recovery. I also described my current research investigating the prevalence of pathogenic antibodies in psychosis and its subsequent treatment. This was followed by a large number of enquiries from members of the public both nationally and internationally. |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.bbc.co.uk/programmes/articles/4dbMnJVnLBM9Qqp8rzKD4s3/could-some-mental-health-conditions... |
Description | Poster Presentation at Encehalitis conference-Iona Cairns |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Poster Presentation of current PPiP2 data at annual encephalitis conference. |
Year(s) Of Engagement Activity | 2020 |
Description | Presentation and Cambridge Neuroscience Seminar 2017 - The Inflamed Brain - 21 March |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary "The Autoimmune basis of Psychosis - challenges and controversies |
Year(s) Of Engagement Activity | 2017 |
URL | http://www.neuroscience.cam.ac.uk/events/event.php?permalink=dbbbdfb739#plenary |
Description | Presentation at 24th Annual NAPICU Conference, Glasgow |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The theme of the conference this year was "Therapeutic Advancements in Acute, Emergency and Secure Mental Health Settings; Reducing Restrictive Interventions". My presentation in the Session on Novel Treatments in Psychiatry was entitled "Autoimmune Causes of Psychosis: Diagnosis and Management |
Year(s) Of Engagement Activity | 2019 |
URL | https://napicu.org.uk/24th-annual-conference-2019-glasgow/ |
Description | Presentation at Cornwall Research Showcase, Eden Project, Cornwall |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | This was a free event hosted by the Research and Innovation Team, Cornwall Partnership NHS Foundation Trust celebrating mental health, adult community health, dementia and learning disability research in Cornwall |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.cornwallvsf.org/noticeboard/notice/cornwall-research-showcase/ |
Description | Presentation at Faculty of Neuropsychiatry Annual Conference 2022 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation title: "Anti-neuronal antibodies and psychosis: what do we know?" |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.emedevents.com/medical-hybrid-events-2022/faculty-of-neuropsychiatry-annual-conference-2... |
Description | Presentation at Mental Health & Neuroimmunology conference, University of Kent |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | This conference was for psychiatrists, neuropsychiatrists, neurologists, GPs, neuropsychologists, mental health and frontline medical staff and will focus on neuroimmunology and links to psychosis, blurring the distinction between mental illness and neurological disorders: the association between autoimmune disease and psychosis |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.kmpt.nhs.uk/media/2229/kmpt-neuroimmunology_-external-version-and-booking.pdf |
Description | Presentation at Oxford Autoimmune Neurology Meeting 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | This was a two-day international meeting on 5-6 June 2019 for clinicians and scientists looking to appreciate the breadth of translational autoimmune neurology. This inaugural meeting covered the clinical features of CNS and PNS diseases, methodological aspects of immunological assays, applied T and B cell pathophysiology, and questions relating to immunological tolerance. By being both contemporary and highly translational, the program appealed to consultant and trainee neurologists plus PhD or postdoctoral level researchers who have an interest in the field of autoimmune neurology. |
Year(s) Of Engagement Activity | 2019 |
URL | https://aealliance.org/oxford-autoimmune-neurology-meeting-2019/ |
Description | Presentation at Portuguese Psychiatry Association Meeting, Coimbra, Portugal |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at Portuguese Psychiatry Association Meeting, Coimbra, Portugal 08-10 February 2019 |
Year(s) Of Engagement Activity | 2019 |
Description | Presentation at Psychoimmunology Meeting, Scientific Institute of Ulm University, Schloss Reisensburg, at Günzburg in Southern Bavaria, Germany. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | . |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation at RCP Advanced Medicine Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation entitled "Autoimmune encephalopathies - latest advances" at Royal College of Physcians Advanced Medicine Conference in Birmingham, 20 June, 2016 |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.rcplondon.ac.uk/events/advanced-medicine-manchester |
Description | Presentation at a medical PostGrad training day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 RA, G Tomei gave a presentation on PPiP2 and SINAPPS2 studies to junior and senior psychiatrists at a medical PostGrad training day organised by Norfolk and Suffolk NHS Foundation Trust. |
Year(s) Of Engagement Activity | 2019 |
Description | Presentation at a research seminar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 RA, SA Vincent gave a presentation on PPiP2/SINAPPS2 to junior&senior psychiatrists |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation at part of Oxford Neuroscience Seminar List |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | There are many lines of evidence to suggest that a proportion of psychosis has an autoimmune basis, however to date there have not been any biomarkers to identify individuals that might benefit from immune modifying treatments. This has potentially changed with the discovery of pathogenic antibodies in patients with autoimmune encephalitis. There are many parallels between autoimmune encephalitis and primary psychotic disorders, however whilst this new knowledge has led to a rapid and widespread change in clinical practice in neurology, there has not been an equivalent change in practice for psychiatry. I will discuss the current level of evidence around the concept of autoimmune psychosis and how psychiatry needs to transform to be able to adequately investigate and treat patients with psychosis. |
Year(s) Of Engagement Activity | 2022 |
URL | https://talks.ox.ac.uk/talks/id/07cb16cf-fc7d-4cfc-a4c4-d598daf263f9/ |
Description | Presentation at the 6th European Conference on Schizophrenia Research (ECSR) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Symposium presentation entitled: "The diagnosis and management of autoimmune encephalitis in psychiatric settings" at the 6th European Conference on Schizophrenia Research (ECSR), 24/11/2016 |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.cpo-media.net/DGPPN/2016/Programm/HTML/files/assets/common/downloads/publication.pdf |
Description | Presentation on SINAPPS2 & PPiP2 to Bradford District Care NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | A talk to researchers on SINAPPS2 & PPiP2 |
Year(s) Of Engagement Activity | 2023 |
Description | Presentation: 6th Annual International Psychiatric Pharmacy Conference of CMHP |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Autoimmune mechanisms of schizophrenia |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.cmhp.org.uk/wp-content/uploads/2015/03/CMHP-Conference-programme-2015-Final-Version.pdf |
Description | Presenting and chairing at Angelini Brain Health Innovation Summit |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting objectives • To provide a platform for sharing the latest research, insights and best practices related to brain health. • To facilitate networking opportunities and interdisciplinary discussions for psychiatrists, neurologists and industry leaders fostering collaboration in the brain health field • To build the foundation for a sustained collaboration focused on driving progress in brain health initiative |
Year(s) Of Engagement Activity | 2023 |
Description | RCPsych Neuroscience Update Event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | An event considering the role of neuroscience throughout the development of the clinical case and see how this directly relates to patient care. Title of talk: "Autoimmunity and Psychosis" |
Year(s) Of Engagement Activity | 2021 |
Description | Research Group Newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS Group Newsletter April 2021 |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.psych.ox.ac.uk/research/autoimmune-psychosis/sinapps-newsletter |
Description | Research Video |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Video: Treating psychosis with immunotherapy? |
Year(s) Of Engagement Activity | 2021 |
Description | Research Webinar |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS Research Group Webinar Youtube Series on clinical and research aspects of autoimmune psychosis: Webinar 2/2021: Dr Sarah Crisp (Cambridge) presents 'Stiff people and their antibodies' |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=dxzbZArAPh4&t=4s |
Description | Research Webinar |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS Research Group Webinar Youtube Series on clinical and research aspects of autoimmune psychosis: Webinar 3/2021: Dr Ester Coutinho (Kings College London) presents 'The patients who changed the field of autoimmune neurology' |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=79LuSXH2CHU&t=104s |
Description | Research Webinar |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS Research Group Webinar YouTube Series on clinical and research aspects of autoimmune psychosis: Webinar 1/2021: Dr Jonathan Rogers (UCL) presents 'Catatonia, infection and immunity' |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=s_13ghEu3gI&t=786s |
Description | Research Webinar |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS Research Group Webinar Youtube Series on clinical and research aspects of autoimmune psychosis: Webinar 4/2021 Professor Angela Vincent (Oxford) presents 'Maternal Immunity and neurodevelopment: a neglected field?' |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.youtube.com/watch?v=GkIN8SzoXgw&t=31s |
Description | SINAPPS research group webinar youtube series Lecture 1 Belinda Lennox Investigation of psychosis for autoimmune causes, who, what and how |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | We organised a webinar series including 6 presentations from consultant psychiatrists/neurologists on the subject of inflammation in psychosis. They have been uploaded to youtube for viewing by general public. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/channel/UCypNckrsAhP6U9Mnf5kHe6Q |
Description | SINAPPS research group webinar youtube series Lecture 2-Professor Alisdair Coles-Does treatment of the autoimmune system affect psychosis-what we know and what we do not |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | We organised a webinar series including 6 presentations from consultant psychiatrists/neurologists on the subject of inflammation in psychosis. They have been uploaded to youtube for viewing by general public. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/channel/UCypNckrsAhP6U9Mnf5kHe6Q |
Description | SINAPPS research group webinar youtube series Lecture 3-Dr Thomas Kabir, taking part in research, what do you do when family and friends disagree? |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | We organised a webinar series including 6 presentations from consultant psychiatrists/neurologists on the subject of inflammation in psychosis. They have been uploaded to youtube for viewing by general public. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/channel/UCypNckrsAhP6U9Mnf5kHe6Q |
Description | SINAPPS research group webinar youtube series Lecture 4 Professor Eileen Joyce, The role of inflammation in first episode psychosis cognitive impairment |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | We organised a webinar series including 6 presentations from consultant psychiatrists/neurologists on the subject of inflammation in psychosis. They have been uploaded to youtube for viewing by general public. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/channel/UCypNckrsAhP6U9Mnf5kHe6Q |
Description | SINAPPS research group webinar youtube series Lecture 5 Dr Mike Zandi, Encephalitis and psychosis lessons from encephalitis lethargica to covid-19 |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | We organised a webinar series including 6 presentations from consultant psychiatrists/neurologists on the subject of inflammation in psychosis. They have been uploaded to youtube for viewing by general public. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/channel/UCypNckrsAhP6U9Mnf5kHe6Q |
Description | SINAPPS research group webinar youtube series Lecture 6 Professor Peter Jones Neurodevelopmental precursors of psychosis and their relevance to clinical practice |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | We organised a webinar series including 6 presentations from consultant psychiatrists/neurologists on the subject of inflammation in psychosis. They have been uploaded to youtube for viewing by general public. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.youtube.com/channel/UCypNckrsAhP6U9Mnf5kHe6Q |
Description | SINAPPS2 - Autoimmune psychosis workshop and dinner |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 - Autoimmune psychosis workshop and dinner |
Year(s) Of Engagement Activity | 2023 |
Description | SINAPPS2 /PPiP2 presentation to Clinicians in Devon Partnership NHS FT (Everything you wanted to know about research) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 team was invited to present SINAPPS/PPiP2 at te Session 10 of the event attended by clinicians (mostly psychiatrists) from the Devon Partnership NHS FT . Event title 'Everything you wanted to know about research" |
Year(s) Of Engagement Activity | 2023 |
Description | SINAPPS2/PPIP2 Newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Newsletter distributed to all research sites participating in PPiP2 and SINAPPS2 |
Year(s) Of Engagement Activity | 2024 |
Description | SINAPPS2/PPiP2 presentation to clinicians in Cheshire and Wirral NHS FT |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Academic meeting of doctors in Cheshire and Wirral NHS FT - invited SINAPPS2 team presenting research in Autoimmune Psychosis (Ksenija Yeeles). |
Year(s) Of Engagement Activity | 2023 |
Description | Science Festival Cambridge |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | A presentation, including from a carer, on antibody-assocaited psychosis |
Year(s) Of Engagement Activity | 2017 |
Description | Seminar presentation to Norfolk and Suffolk NHS Foundation Trust researchers |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk title: "Causes of Hearing Voices" |
Year(s) Of Engagement Activity | 2022 |
Description | Speak and Nottingham academic meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak and Nottingham academic meeting |
Year(s) Of Engagement Activity | 2021 |
Description | Speak at Psychosis Studies Meeting, IOPPN |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak and Nottingham academic meeting. Talk title: "Autoimmune psychosis - hope or hype?" |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to Sheffield Grand Round |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to Sheffield Grand Round |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at Camden and Islington NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at Camden and Islington NHS Foundation Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at Coventry and Warwickshire Partnership NHS Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at Coventry and Warwickshire Partnership NHS Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at Gloucester Health and Care N H S Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at Gloucester Health and Care N H S Foundation Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at Hertfordshire Partnership NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at Hertfordshire Partnership NHS Foundation Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at Lincolnshire Partnership NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at Lincolnshire Partnership NHS Foundation Trust re PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at North East London N H S Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at North East London N H S Foundation Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at Rotherham Doncaster & South Humber NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at Rotherham Doncaster & South Humber NHS Foundation Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at South London and Maudsley NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation to PPiP2 research team |
Year(s) Of Engagement Activity | 2022 |
Description | Speak to research and clinical staff at South West London and St George's Mental Health NHS Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at South West London and St George's Mental Health NHS Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to research and clinical staff at Surrey and Borders Partnership NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to research and clinical staff at Surrey and Borders Partnership NHS Foundation Trust RE. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speak to trainee doctors at Greater Manchester Mental Health NHS Foundation Trust |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Speak to trainee doctors at Greater Manchester Mental Health NHS Foundation Trust re. PPiP2/SINAPPS2 |
Year(s) Of Engagement Activity | 2021 |
Description | Speaker and symposia chair at 14th International Society of Neuroimmunology Congress, Brisbane, Australia |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary session on neuroimmunology of schizophrenia and depression. Joint chair of symposium on Neuroimmune Psychiatry - "Autoimmune psychosis - fact or fiction"? |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.isniweb.org/wp-content/uploads/2019/01/PROGRAM.pdf |
Description | Speaker at Royal College of Psychiatrists Faculty of Child and Adolescent Psychiatry Annual Scientific Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Symposium 2: Inflammation and mental illness |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.rcpsych.ac.uk/docs/default-source/events/programmes/rcpsych-cap2019-programme-v4.pdf?sfv... |
Description | Speaker at The Lancet Summit: Inflammation and Immunity in Disorders of the Brain and Mind, Barcelona, Spain |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation: Neuropsychiatric manifestations of neuronal autoantibodies Poster: Being autoimmune in psychiatric places: 10 characteristic mental state features in patients with definite NMDAR antibody encephalitis determined by detailed phenotyping |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.thelancetsummit.com/conference-programme.asp |
Description | Speaker at UCL Divisional Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation |
Year(s) Of Engagement Activity | 2019 |
Description | Talk at The 7th Oxford Neurology Course |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Presentation entitled: "The neuropsychiatric manifestations of NMDAR antibodies" a the 7th Oxford Neurology Course, St Anne's College, Oxford 29th June 2016 |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.ndcn.ox.ac.uk/events/7th-oxford-neurology-course-programme.pdf |
Description | Talk at a meeting of mental health service users |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | "hearing voices" event in Norwich on the 10th of November 2017 |
Year(s) Of Engagement Activity | 2017 |
Description | Talk on SINAPPS2 and PPIP2 to Devon Partnership NHS Trust by Brendan Sargent |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation to Research Team at Devon Partnership NHS Trust encouraging participation and recruitment by research/clinical staff |
Year(s) Of Engagement Activity | 2024 |
Description | Talk on autoimmune psychosis to general psychiatrists |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk to regional psychiatrists |
Year(s) Of Engagement Activity | 2019 |
Description | Talk on behaviour and the immune system |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Talk given at the Cambridge Summer School |
Year(s) Of Engagement Activity | 2018 |
Description | Talk to St John's College Medical Society, Oxford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | A talk to the St John's Medical Society on the subject of Antibodies and Psychiatry. |
Year(s) Of Engagement Activity | 2015 |
Description | Talk to neurologists in Nottingham |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Departmental Nottingham Talk |
Year(s) Of Engagement Activity | 2020 |
Description | Talk with Norfolk and Suffolk NHS Foundation Trust psychiatrists regarding SINAPPS-2 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk with Norfolk and Suffolk NHS Foundation Trust psychiatrists regarding SINAPPS-2 |
Year(s) Of Engagement Activity | 2021 |
Description | Talk with Nottingham Inpatient Psychiatrists regarding SINAPPS-2 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk with Nottingham Inpatient Psychiatrists regarding SINAPPS-2 |
Year(s) Of Engagement Activity | 2021 |
Description | Talk with SINAPPS-2 Psychiatrists and research site staff in Essex |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk with SINAPPS-2 Psychiatrists and research site staff in Essex |
Year(s) Of Engagement Activity | 2020 |
Description | Talk with SINAPPS-2 research site staff in Devon |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk with SINAPPS-2 research site staff in Devon |
Year(s) Of Engagement Activity | 2020 |
Description | Talk with SINAPPS-2 research site staff in Greater Manchester |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk to SINAPPS-2 research site staff in Greater Manchester |
Year(s) Of Engagement Activity | 2020 |
Description | Talk with SINAPPS-2 research site staff in South Yorkshire |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk with SINAPPS-2 research site staff in South Yorkshire |
Year(s) Of Engagement Activity | 2020 |
Description | Talk with SINAPPS-2 research site staff in Stockport |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | A training discussion with SINAPPS-2 site research staff |
Year(s) Of Engagement Activity | 2020 |
Description | West Suffolk Post graduate teaching - SINAPPS2 and PPIP2 talk by Ksenija Yeeles |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | KY gave talk to 8-99 doctors in West Suffolk Post Graduate Teaching session on Wed, 10 January 2024 presenting SINAPPS2/PPiP2 research. |
Year(s) Of Engagement Activity | 2024 |
Description | Yorkshire Neurology Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Yorkshire Neurology Meeting |
Year(s) Of Engagement Activity | 2020 |
Description | multiple media appearances TV and radio, to coincide with publication of paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | multiple media appearances on 8th December 2016, including: The Today programme Radio 4 at 06:33, 07:22, Victoria Derbyshire show BBC2 09.30, BBC World service hourly television, and radio news, One O'Clock news, Six O'Clock news. Also in print in: Daily Mail, The Telegraph, The Metro, Mail on Sunday |
Year(s) Of Engagement Activity | 2016 |
Description | poster presentation at Brainworks 2018 Research Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | SINAPPS2 RA, G Tomei presented a poster on PPiP2 and SINAPPS2 at a Neuroscience, Psychiatry and Neurology research event for carers, patients and professionals. PPiP2 leaflets were made available for attendees. The poster generated interest and numerous questions from roughly 15 attendees between general public, clinical professionals and academics. |
Year(s) Of Engagement Activity | 2018 |
Description | poster presentation at Encephalitis Conference 2018, organised by Encephalitis Society, |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 RA, SA Vincent was invited to present a poster at Encephalitis Conference 2018 organised by Encephalitis Society, |
Year(s) Of Engagement Activity | 2018 |
Description | poster presentation at a research event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 RA, G Tomei was invited to present a poster about PPiP/SINAPPS studies at the Cambridgeshire Research Event: Better diagnosis for better treatment |
Year(s) Of Engagement Activity | 2017 |
Description | presentation at a research event |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | SINAPPS2 RA,G Tomei was invited to speak on SINAPPS2 trial at a research event organised by Lincolnshire Partnership NHS Trust |
Year(s) Of Engagement Activity | 2017 |