MRC Centre for Reproductive Health at the University of Edinburgh

Lead Research Organisation: University of Edinburgh
Department Name: MRC Centre for Reproductive Health

Abstract

Abnormalities associated with reproductive system and reproductive processes are common in modern society affecting both man and women. They result in major physical and psychological burden on many individuals. They also have huge impact on UK health system and economy. A few representative examples include: endometriosis which affects 1 in 10 women of reproductive age in the UK and cost the UK economy £8.2 billion a year in treatment, loss of work and healthcare costs; stillbirth - there are more than 3,600 stillbirths every year in the UK, and one in every 200 births ends in a stillbirth; and ovarian cancer that in UK alone kills nearly 12 women every day. Importantly, reproductive health problems are often linked to lifestyle factors such as smoking and obesity, but these links are not completely understood.

The Medical Research Council - Centre for Reproductive Health in Edinburgh (MRC-CRH) is the only UK-based reproductive health/biology centre that brings together basic scientists, diagnosticians and clinicians specialising in health, biology and pathology of reproductive system and reproductive processes at all levels: from genes and molecules to population based studies and lifestyle-disease links. The Centre is located in the world-renowned Queen's Medical Research Institute in the direct proximity of the Edinburgh Royal Infirmary (a teaching hospital for the University of Edinburgh Medical School run by NHS Lothian), a few other top class research institutions and a commercialisation incubator (Edinburgh BioQuarter). This optimises the use of resources, increases interdisciplinary collaborations and enhances commercialisation activities. Over the past five years the Centre grew significantly in both staff numbers and its research output and proved its value to society, for example, a single "STOPPIT" study on efficiency of progesterone treatment in preterm birth prevented 11,000 patients from painful ineffective treatment in the UK alone saving NHS £M annually.

Within the next five years we intend to build on our past achievements to boost MRC-CRH research/education potential and infrastructure of the Centre. The main aims of this project are to (i) consolidate and reinforce MRC-CRH scientific activities, (ii) increase the Centre's educational role, and (iii) enhance interactions of the Centre's investigators and students with patients, medical practitioners and general public, rising awareness about reproductive health conditions and other topics related to our research. MRC funds will be used to (a) purchase specialised equipment that will increase research capability and open new frontiers for future investigations (micro-injection and oocyte handling, sophisticated interference and fluorescent microscopy), (b) recruit necessary expert personnel in imaging technology, database management/bioinformatics and scientific communication to sustain/expand our research capacity and outreach activities, (c) establish a top quality PhD programme in reproductive health/biology for clinical and non-clinical scientists.

It is our ambition through another five years of MRC funding to maintain and expand our world-class research into new areas including cancers of the reproductive tract, the effects of life-style (obesity, smoking etc.) on reproductive health and proliferative disorders of the reproductive system. It is our aim that our discoveries will impact the health and well-being of the Nation's population through their entire life-span. This improvement in health will have significant consequences for individuals, families and the society in general with noticeable economic benefits.

Technical Summary

The MRC-CRH will integrate its proven strengths in reproductive health and biology (training, multilevel basic/clinical research, clinical trials and implementation of new treatments/procedures) around four scientific themes linking basic and clinical researchers to enhance translational output: (1) Reproductive resilience, proliferation, differentiation and repair; (2) Reproductive system cancers: aetiology, pathogenesis and therapy; (3) Optimizing life-long health through pregnancy and perinatal interventions; (4) Immune-endocrine interactions in reproductive health. These will be reinforced by a dedicated interdisciplinary reproductive health/biology PhD training programme (3-4 years) for both clinical and non-clinical scientists. The programme will produce and sustain a generation of new academic/clinical reproductive health/biology experts increasing UK research capacity in this important field. Emphasis will be put on extending our current research infrastructure by implementing state-of-the-art technologies in micro-injection and oocyte handling and increasing our capabilities for in situ quantitative monitoring of biological processes using real-time intravital fluorescent and interference microscopy. This will be associated with recruitment of imaging specialist and database manager to maintain the systems, provide training and facilitate image processing, analysis and bioinformatics. We intend to enhance our general public training/education activities and online presence which will be facilitated by recruitment of a dedicated scientific communications manager.

Planned Impact

Diverse aspects of reproductive biology/health influence the society at multiple levels (health/wellbeing, lifestyle, culture, economy etc.) and are essential for survival of mankind. Basic, translational and clinical research performed at the MRC-CRH impacts a number of people, organisations and sectors in the population at local, national and global scale. Main non-academic beneficiaries of our activities include:
(a) Policymakers, public health educators and general population. Our research and clinical trials continuously provide data that directly informs many guidelines for treatment and lifestyle advice for the population. This is facilitated by MRC-CRH members siting in various advisory bodies linked to organisations playing leading roles in policy development nationally and internationally (e.g. The National Institute for Health and Care Excellence; World Health Organisation). Usually it takes at least a few years (2-5) to convey MRC-CRH generated clinical data into active public policies but we have also examples of much faster impact (e.g. results of "Outcomes of elective induction of labour compared to expectant management: a population based study" translated into international policy changes in less than 2 years from original publication (Stock et al. BMJ. 2012;344:e2838)). Our studies will inform the health of all of society, for example investigations on the effects of obesity, smoking and stress on pregnancy will lead to lifestyle advice to the population. Similarly studies in contraception (particularly male contraceptives), if successful, may lead to alteration in behaviour.
(b) Patients, their relatives and friends. Patients benefit from our research directly through ability to use new therapeutic approaches (e.g. MRC-CRH Anderson co-developed new procedures and protocols for freezing of ovarian tissue to allow women to have children after cancer therapy), possibility to get exposed to novel (potentially life-changing) therapies at clinical trial stage and patient-directed educational activities, and indirectly through improved health policies and practices that we impact. Pregnancy and healthy birth are not only life-changing events for a woman but they usually also have enormous impact on her family and friends. Routine induction of labour at 39 weeks for all women stemming from our research is calculated to prevent the perinatal death of 500 babies per year and we will continue our efforts to further improve this figure.
(c) NHS and health system. Our research influences NHS standards and operating procedures, it also leads to identification of improved or ineffective treatments and significant savings/ better allocation of resources in the health system (e.g. STOPPIT study led by Norman showed that progesterone was ineffective in women with tween pregnancy and has prevented ineffective treatment of 11,000 women annually with huge savings for NHS). Our research often targets conditions that increase morbidity without being life-threatening (e.g. endometriosis, fibroids and heavy menstrual bleeding), these conditions are associated with enormous strain on the health system and big economic costs through loss of work.
(d) Medical practitioners. These people benefit from our contributions to general medical knowledge (e.g. Pollard's research has been described in textbooks such as "Molecular Biology of the Cell" and "Pathophysiology" where his work is featured on the front cover.), regular training opportunities and increased patient/general public awareness about reproductive system health and diseases promoted by MRC-CRH.
(e) Economy and commerce. Our spinout company Ichthus Therapeutics is developing novel products focused on women's health (in particular endometriosis and endometriosis-associated pelvic pain). Within the next 5 years we plan to spin out additional companies and facilitate increase in job opportunities and capital gain generated by them with direct benefit for local economy.

Publications

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Anderson RA (2018) Being a good egg in the 21st century. in British medical bulletin

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Anderson RA (2018) The impact of cancer on subsequent chance of pregnancy: a population-based analysis. in Human reproduction (Oxford, England)

 
Description "Oestrogens - the good, the bad, and the unexpected" talk at the Society for Endocrinology annual meeting, Glasgow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Evan Simpson gave a symposium talk at the Society for Endocrinology annual meeting in Glasgow in November entitled "Oestrogens - the good, the bad, and the unexpected".
Year(s) Of Engagement Activity 2018
 
Description '31st Annual Critical Issues in Tumor Microenvironment Course : from Bench to Bedside to Bomarkers' Harvard, Boston 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker/Assessor : Angiogenesis, Metastasis and Immunology
Year(s) Of Engagement Activity 2016
 
Description 'It gives you hope': the fight to save the fertility of children with cancer, Interview with The Guardian, United Kingdom 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof. Richard Anderson and Dr. Rod Mitchell were involved in an interview by the Guardian, to talk about how their technology and medical procedures could prevent infertility in babies, children and teenagers with cancer treatment.
Year(s) Of Engagement Activity 2018
 
Description 'Licensing the Immune System in Health & Disease' University of Basel, Switzerland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker, 5th Basel Immunology Focus Symposium (BIFS)
Year(s) Of Engagement Activity 2017
 
Description 'Regulatory Myeloid Cells: From Basic Discovery to Therapeutic Application' Conference, The Wistar Institute, Philadelphia, US. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This conference focused on the pathological functions of myeloid-derived suppressor cells, dendritic cells, macrophages and neutrophils, and provided a forum for in-depth discussion of the most pressing issues associated with the biology and clinical application of these cells. The conference brought together scientists from academia and industry interested in the basic and translational aspects of these cells in pathological conditions, especially cancer.
Year(s) Of Engagement Activity 2016
URL https://sitc.sitcancer.org/sitc-meetings/collaborative/wistar2016
 
Description 'The Year My Vagina Tried to Kill Me' post-dicussion, Manchester 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Andrew Horne teamed up with comedian Amy Vreeke to answer audience questions about endometriosis. The event was held in Manchester and was recorded as an engaging an informative event which broached serious subjects couched in comedy.
Year(s) Of Engagement Activity 2019
 
Description 'Understanding Tumor Immunology' - Speaker 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Beatson Institute for Cancer Research workshop on Tumor Immunology, Glasgow UK
Year(s) Of Engagement Activity 2017
 
Description 100 years of Phagocytes, Mario Teti Foundation, Messina: Cell Symposium, Sicily, Italy 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Bringing together cell biologists, immunologists, and developmental biologists interested in exploring phagocytes' diverse roles in tissue biology, identifying gaps in our current knowledge and defining disease pathways.
Year(s) Of Engagement Activity 2016
 
Description 10th workshop of the European Network of Breast Development and Cancer labs (ENBDC); Weggis, Switzerland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Macrophage maleficence in cancer
Year(s) Of Engagement Activity 2018
 
Description 1st National Symposium on Immunology and Immunotherapy of Cancer. Amsterdam, Netherlands 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Tumor Associated Macrophages: From mechanism of action to therapy
Year(s) Of Engagement Activity 2016
 
Description 2017 Early Detection of Cancer Conference - Speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Annual Conference of Cancer Research UK and OHSU Knight Cancer Institute 2017
Year(s) Of Engagement Activity 2017
 
Description A long-term study into the causes of premature birth has been launched by Sarah Brown, wife of former prime minister Gordon Brown. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The Theirworld Edinburgh Birth Cohort will track the development of 400 babies, mostly born before 32 weeks, following them through to adulthood.
The research at the University of Edinburgh MRC Centre for Reproductive Health is being funded with a £1.5m grant from the global children's charity Theirworld, of which Ms Brown is founder and president.
Year(s) Of Engagement Activity 2016
 
Description AACR 107th Annual Meeting 2016, New Orleans 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker : CIMM/TME Joint Scientific Session
Year(s) Of Engagement Activity 2016
 
Description AACR Seattle US 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Delivering Cures Through Cancer Scienc
Year(s) Of Engagement Activity 2016
URL https://ecancer.org/conference/calendar/786-aacr-2016.php
 
Description American Society for Cell Biology (ASCB) 'Cell Biology of Cancer' First Bookstop Symposium, San Francisco 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker : Macrophages Are a Cellular Toolbox That Promotes Tumor Progression and
Metastasis
Year(s) Of Engagement Activity 2016
 
Description BACR special conference : 'The tumour microenvironment - basic science to novel therapies', University of Nottingham, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The conference covered a wide number of topics with sessions on tumour angiogenesis, hypoxia and metabolism, stroma, cancer and the immune system and the interstitial-stem cell niche. The focus of the conference was to give a broad overview of the tumour microenvironment by discussing important topics such as those described above.
Year(s) Of Engagement Activity 2017
 
Description BBC Breakfast, United Kingdom 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Andrew Horne was interviewed by BBC Breakfast journalist Emma Barnett.
Year(s) Of Engagement Activity 2019
 
Description BBC News Interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Jeffrey Pollard gave an interview to the BBC broadcasted live on Friday 4th March 2016. In this interview Prof Pollard commented on Nicholas Mc Granahan, Andrew Furness and Rachel Rosenthal's recent paper "Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade" published in Science.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/health-35718491
 
Description BBC Radio Sheffield & BBC Woman's Hour - Feeding your Baby Poll, United Kingdom 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Erin Williams was on BBC Sheffield to discuss the results of a survey about how women feed their babies and how it makes them feel.
Year(s) Of Engagement Activity 2019
 
Description BBC Scotland 'The Nine', Edinburgh 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Andrew Horne was interviewed by BBC Scotland to talk about Edinburgh's EXPPECT Centre for Pelvic Pain and Endometriosis.
Year(s) Of Engagement Activity 2019
 
Description BBC Stories, London 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Prof Andrew Horne was interview by the 'bbcstories' short film in London.
Year(s) Of Engagement Activity 2019
 
Description Bid to ease burden of heavy periods steps up with new drug trial 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Women who suffer heavy periods are being invited to join a research study to test a new treatment for their condition.

The trial will find out if boosting levels of a hormone produced in the lining of the womb can reduce blood loss during menstruation and ease women's symptoms.

Researchers believe that a hormone - called cortisol - helps the small blood vessels in the womb lining to function well.

If cortisol levels are too low in the womb, it can increase blood loss, researchers say.

This study will test whether a drug that mimics the actions of cortisol - called dexamethasone - will boost the hormone to typical levels and reduce menstrual blood loss.

The research aims to identify whether a short course of the drug, at a low dose, could also be used to manage heavy periods.

Women who join the study will be asked to monitor their periods for two months.

They will then be randomly assigned to receive either a short course of dexamethasone or a placebo pill for five days before their period is due, for the following three months.

As is usual in clinical trials, neither the doctors nor the participants will know which medication they receive.

Professor Hilary Critchley of the University of Edinburgh's MRC Centre for Reproductive Health, who is leading the trial, said: "Women who experience heavy bleeding during their period will often struggle with very challenging symptoms that impact their daily life.

"Many of the current treatment options such as the contraceptive pill or hysterectomy affect a woman's fertility, and so we are keen to develop treatments that offer women a greater choice. Now we need more participants - to complete this vital research".
Year(s) Of Engagement Activity 2016
 
Description Brain and Spine Institute, Paris 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Veronica Miron gave a talk at the Brain and Spine Institute in Paris, a world renowned institute for glial biology.
Year(s) Of Engagement Activity 2019
 
Description Brainwaves, BBC Radio 4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Hilary Critchley was featured on the BBC Radio 4 popular series 'Brainwaves' to discuss about the importance of communicating about menstrual health.
Year(s) Of Engagement Activity 2019
 
Description CRUK Scotland St. Andrews Day 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Jeff Pollard featured in the CRUK Scotland's Twitter post on St Andrew's Day, thanking all their supporters in Scotland. Jeff explained why this support is valued in the academic community to help save more lives through research.
Year(s) Of Engagement Activity 2019
 
Description Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment, Keystone Symposia, Florence 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Binzhi was invited to give a plenary talk in Keystone Symposia, Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment, held at the Florence, Italy.
Year(s) Of Engagement Activity 2019
 
Description Cancer drug may cause women to grow new eggs, study suggests 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Women treated with a common chemotherapy drug combination have more young eggs in their ovaries afterwards, research has found.

A small study indicates that a therapy commonly used to target Hodgkin's lymphoma appears to increase the number of non-growing eggs in women's ovaries.

Researchers say it is too soon to link the outcome to fertility, but believe more research is needed to better understand the findings and their implications.

Scientists from the University of Edinburgh analysed samples of ovary tissue donated by 14 women who had undergone chemotherapy, and from 12 healthy women.

They found that the ovaries from eight of the cancer patients, who had been treated with a drug combination known as ABVD, had a much greater incidence of immature, or non-growing, eggs compared with tissue from women who had received a different chemotherapy, or from healthy women of a similar age.

The ovary tissue was seen to be in healthy condition, appearing similar to tissue from young women's ovaries.

If further research can reveal the mechanism by which treatment with ABVD results in increased production of eggs, this would aid understanding of how women might be able to produce more eggs during their lifetime, which was until recently thought to be impossible.

Researchers had set out to better understand why treatment with ABVD is one of the few cancer drug combinations that does not impact on women's fertility.

Future studies will examine the separate impact of each of the four drugs that combine to make ABVD - known as adriamycin, bleomycin, vinblastine and dacarbazine - to better understand the biological mechanisms involved.

The study, published in Human Reproduction, was supported by the Medical Research Council.

Lead researcher Professor Evelyn Telfer, of the University of Edinburgh's School of Biological Sciences, said: "This study involves only a few patients, but its findings were consistent and its outcome may be significant and far-reaching. We need to know more about how this drug combination acts on the ovaries, and the implications of this."
Year(s) Of Engagement Activity 2016
 
Description Cell Symposium : Hallmarks of Cancer. Ghent, Belgium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker : Cell-VIB Symposium: Hallmarks of Cancer
Year(s) Of Engagement Activity 2016
 
Description Challenge your expert session (ESMO) Oxford, UK 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Discussion forum
Year(s) Of Engagement Activity 2017
 
Description Charles Easton Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Tumor Associated Macrophages - from Mechanism to Therapy"
Year(s) Of Engagement Activity 2016
 
Description Chemotactic Cytokines Gordon Research Conference, Girona, Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A chance to uncover the advanced improvements in Biological Chemistry, Cytokines and Chemotactic Cytokines at this important Conference.
Year(s) Of Engagement Activity 2016
 
Description Clinical Trials Collaboration with Ugandan University in Development, Edinburgh and Uganda 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Fiona Denison hosted a two day multidisciplinary meeting this autumn with colleagues from Makerere University, Uganda. The discussion explored the clinical trial partnership and the design and development of a medical device for obstetric haemorrhage. Fiona Denison also ran a workshop in October on developmental care for preterm babies in Kampala, Uganda in collaboration with Makerere University.
Year(s) Of Engagement Activity 2019
 
Description College of Medicine and Veterinary Medicine Summer Work Experience, Edinburgh 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact High school students toured around The Queen's Medical Research Institute and engaged in interactive sessions with Roseanne Rosario, Mike Miller and Mike Rimmer.
Year(s) Of Engagement Activity 2019
 
Description Croucher Summer Course & Symposium : Advances in Immunology in Health & Diseases, Hong Kong 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker/Lecturer/Assessor : Conference which focussed on such immunology research, including abnormal immune level responses that lead to cancer and autoimmunity development. This is essential in elucidating the cause of common disorders and could facilitate the design of more specific, efficient and safe therapies through immunoregulation.
Year(s) Of Engagement Activity 2018
 
Description Dan L Duncan Lecture; Breast Disease Program, Baylor College of Medicine, Houston, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oncology Lecture
Year(s) Of Engagement Activity 2018
URL https://www.bcm.edu/centers/cancer-center/events
 
Description Dewitt Goodman Seminar, Columbia University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A talk in the Dewitt Goodman Seminar series at Columbia University in New York.
Year(s) Of Engagement Activity 2016
 
Description Distinguished guest lecture : University of Pennsylvania School of Medicine, Institute for Regenerative Medicine at UPENN, Philadelphia, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Distinguished lecture series
Year(s) Of Engagement Activity 2018
 
Description Distinguished guest lecture; Kitasato University, Tokyo, Japan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Distinguished guest lecture.
Year(s) Of Engagement Activity 2017
 
Description Distinguished guest lecture; Washington University, St Louis, Ohio. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oncology and cancer biology
Year(s) Of Engagement Activity 2018
 
Description Edinburgh Centre for MS Research, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Irene Molina gave a talk at the Edinburgh Centre for MS Research.
Year(s) Of Engagement Activity 2019
 
Description Endometriosis Research Now, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Professor Andrew Horne organised an Endometriosis Scientific Research Conference 'Endometriosis Research Now' with Philippa Saunders, Jackie Maybin, Doug Gibson and psychologist Sarah Young. The conference was held for those with endometriosis, their supporters and friends in collaboration with World Endometriosis Research Foundation, the World Endometriosis Society and EXPPECT Endometriosis Team.
Year(s) Of Engagement Activity 2019
 
Description Endometriosis study at the MRC Centre for Reproductive Health, Edinburgh 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact The MRC Scottish Showcase event brochure featured a case study on endometriosis research undertaken by Andrew Horne and his team at the EXPPECT Centre for Pelvic Pain and Endometriosis, at CRH.
Year(s) Of Engagement Activity 2019
 
Description European Network of Trainees in Obstetrics & Gynaecology, Poland 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Michael Rimmer was chosen to represent the UK at the European Network of Trainees in Obstetrics & Gynaecology (ENTOG) in an exchange in Poland based in Lublin and Warsaw. He attended a conference in Warsaw, the theme of which was 'Reproductive Health and Prenatal Testing'.
Year(s) Of Engagement Activity 2019
 
Description European Society for Medical Oncology (ESMO) Congress, Madrid 'Challenge your expert' Session 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 'Challenge your expert' - Management of patients on immunotherapy. Discussion.
Year(s) Of Engagement Activity 2017
 
Description Expert reaction to abstract on air pollution and ovarian reserves, Science Media Centre 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Richard Anderson was quoted on an article featured on the Science Media Centre website.
Year(s) Of Engagement Activity 2019
 
Description Expert reaction to new report from the Environmental Audit Committee on toxic chemicals in the home, Science Media Centre 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Rod Mitchell was quoted on an article featured on the Science Media Centre website.
Year(s) Of Engagement Activity 2019
 
Description Expert reaction to study looking at chemicals in plastics and childhood obesity, 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Rod Mitchell was quoted on an article featured on the Science Media Centre website.
Year(s) Of Engagement Activity 2019
 
Description Expert reaction to study on stress in early pregnancy and sperm count in male offspring, Science Media Centre website 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Rod Mitchell was quoted on an article featured on the Science Media Centre website.
Year(s) Of Engagement Activity 2019
 
Description Exploring the science behind the headlines - In-utero exposure to painkillers and future health, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Rod Mitchell was invite to talk about environmental disruptors at the Old Bell Inn Edinburgh.
Year(s) Of Engagement Activity 2019
 
Description Fertility Preservation public lecture A fertile future - preserving fertility in young people with cancer 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public lecture as well as meeting: A fertile future - preserving fertility in young people with cancer
Year(s) Of Engagement Activity 2017
 
Description Fragile X-associated premature ovarian insufficiency, Wellbeing of Women 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact PHD Student Roseanne Rosario describes her ground-breaking research into Fragile X- associated premature ovarian insufficiency.
Year(s) Of Engagement Activity 2019
 
Description Frozen tissue service offers fertility hope for children with cancer 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Young people with cancer are set to benefit from a new service that aims to restore their fertility following chemotherapy.
Scientists are freezing tissue from the reproductive organs of boys and girls as young as one, which can be re-implanted once they reach adulthood.
The announcement follows the birth of the first baby in the UK to be born after his mother had a transplant of her own, previously frozen ovary tissue.
The 33-year-old from Edinburgh had a section of her ovary removed 11 years ago after being diagnosed with a rare form of cancer.
Following her chemotherapy, doctors re-implanted the tissue last year in the hope of restoring her fertility.
The woman, who wishes to remain anonymous, conceived naturally and gave birth to a healthy baby boy earlier this month.
Her success, which was led by a team at the University of Edinburgh, has been welcomed as a milestone in the effort to help young people with cancer and other diseases whose treatment threatens their fertility.
Chemotherapy and radiotherapy are known to have serious side effects on reproductive organs. If children are given these treatments before they reach puberty, it can render them infertile in later life.
By removing the tissue from children before they undergo cancer treatment, it is possible to protect it from side effects that can render patients infertile.
Scientists say restoring fertility in men can be more challenging than in women because the testicular tissue of prepubescent boys is not yet able to produce sperm. By comparison, girls are born with a full complement of egg cells which can be frozen for transplant at a later stage.
Researchers say the new service, led from the University of Edinburgh, is open to NHS patients.
Year(s) Of Engagement Activity 2016
 
Description GEM3 Trial Information Day, Edinburgh 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Prof Andrew Horne's research team hosted a very successful GEM3 Trial Information Day on 12 April in Edinburgh, with nearly 50 attendees, representing over 30 sites.
Year(s) Of Engagement Activity 2019
 
Description Gordon Research Conference on Germinal Stem Cell Biology, Hong Kong 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gabriele Matilionyte attended Gordon Research Conference on Germinal Stem Cell Biology in Hong Kong and presented a poster.
Year(s) Of Engagement Activity 2019
 
Description How to Recognize and Treat an Ectopic Pregnancy, The New York Times, USA 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Prof Andrew Horne contributed to an article on ectopic pregnancy in the New York Times
Year(s) Of Engagement Activity 2019
 
Description Human tumor-associated macrophage transcriptional landscape in sold tumors, Immun-oncology day, Brussels 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Luca Cassetta gave a talk titled Human tumor-associated macrophage transcriptional landscape in sold tumors at the Immun-oncology day in Brussels on 1st February.
Year(s) Of Engagement Activity 2019
 
Description Inflammation Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public engagement event: Inflammation to improve reproductive health across the life-course.
Year(s) Of Engagement Activity 2017
 
Description Inflammation in the brain and body' symposia, The College of Medicine and Veterinary Medicine, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Veronica Miron presented a talk and Irene Molina a poster at the College of Medicine and Veterinary Medicine: 'Inflammation in the brain and body' symposia. This was presented at the University of Edinburgh, Scotland.
Year(s) Of Engagement Activity 2019
 
Description Innovation in breast cancer; Madrid, Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Two-day international scientific programme aims to provide state-of-the-art information on breast cancer achieving a balance of clinical, translational, and basic research and providing a forum for interaction, communication, and education for medical oncologist, gynaecologists and other specialists with a special interest in breast cancer.
Year(s) Of Engagement Activity 2018
 
Description Institute of Immunity and Transplantation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Distinguished guest lecture : Macrophage maleficence in cancer
Year(s) Of Engagement Activity 2018
 
Description Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Infection, Immunity and Inflammation
Year(s) Of Engagement Activity 2017
 
Description Interdisciplinary Life Science Seminar Series (LSSS), University of Zurich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Distinguished guest lecture
Year(s) Of Engagement Activity 2016
 
Description Interview for BBC Radio Scotland's 'Brainwaves', United Kingdom 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor James Boardman, neonatologist and Scientific Director of the Jennifer Brown Laboratory in Edinburgh, talks about his research into the effects of a baby being born too small or too soon on how the brain develops outside the womb. Its a fascinating, engaging and emotionally challenging role which sees him tread a path between time working as an NHS consultant with premature babies in Edinburgh's Royal Infirmary neonatal care unit and conducting research with these tiny babies using state of the art technology and brain imaging techniques to try to understand the causes and consequences of pre-term birth.
Year(s) Of Engagement Activity 2019
 
Description Interview with The Indepedent and Talk Radio 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Prof Andrew Horne was interviewed in the Independent and by Eamonn Holmes on TalkRadio where he highlighted the need for increased research funding for endometriosis.
Year(s) Of Engagement Activity 2019
 
Description Invited lectures, 5th EMEL Conference, Dubai 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Andrew Horne gave three lectures outlining his research into endometriosis at the 5th EMEL Conference in Dubai.
Year(s) Of Engagement Activity 2019
 
Description Invited lectures, British Neuropathology Association, the International Society of Magnetic Resonance in Medicine, British Maternal & Fetal Medicine Society, United Kingdom 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact James Boardman gave invited lectures to the British Neuropathology Association, the International Society of Magnetic Resonance in Medicine, and the British Maternal & Fetal Medicine Society.
Year(s) Of Engagement Activity 2019
 
Description Invited presentation, European Academy of Neurology meeting, Oslo 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Veronique Miron presented at the European Academy of Neurology meeting in Oslo.
Year(s) Of Engagement Activity 2019
 
Description Invited presentation, International Society for Neurochemistry Satellite Meeting, Quebec 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Veronique Miron presented at the International Society for Neurochemistry satellite meeting in Quebec.
Year(s) Of Engagement Activity 2019
 
Description Jackie Maybin and MSP: Parliamentary Pairing Scheme 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Visits Westminster - return visit TBC
Year(s) Of Engagement Activity 2017,2018
 
Description Kampala Workshop, Kampala, Uganda 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Fiona Denison successfully led a 3 day workshop in Kampala, Uganda. The delegation agreed to focus on 3 projects related to neonatal and perinatal causes of death, training of personnel, and emergency care. Potential funders were discussed to include the MRC, NIHR, EPSRC and GCRF.
Year(s) Of Engagement Activity 2019
 
Description Keynote Speaker, 1st Symposium of the Occitanie Network Monocytes/Macrophages, Montpelier, France 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Internationally renown experts in the field of macrophage ontogeny, and macrophage role in tissue regeneration and diseases.
Year(s) Of Engagement Activity 2017
 
Description Keynote speaker, 2nd Symposium on Cellular Crosstalk in the Tumor Microenvironment, Georg-Speyer Haus, Frankfurt 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact keynote lecture - Dynamic interplay between macrophages and tumor cells promotes malignancy
Year(s) Of Engagement Activity 2017
URL http://www.georg-speyer-haus.de/fileadmin/images/sonstige_Veranstaltungen/Program_2Symposium_Oct_13-...
 
Description Klenk Symposium, Speaker 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Tissue regeneration, wound healing and fibrosis: Translating basic concepts into regenerative therapy.
Year(s) Of Engagement Activity 2017
 
Description Lack of cash hinders research into condition affecting 10% of women, The Scotsman website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Andrew Horne highlighted that lack of funding hinders endometriosis research in an article that he co-wrote for The Scotsman.
Year(s) Of Engagement Activity 2019
 
Description MRC Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Festival - endometriosis
Year(s) Of Engagement Activity 2017
 
Description MRC Scottish showcase at Scottish Parliament, United Kingdom 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact CRH attended the MRC Scottish showcase at Scottish Parliament on 6 February, along with eight other MRC Scottish Centres, to highlight the vital work we do in fertility preservation in young cancer patients and research into obesity in pregnancy. Rod Mitchell and Emma Johns ran an interactive stand to inform politicians on their current research and the impact it is having in Scotland, the UK and beyond. The CRH researchers offered MSPs the opportunity to look at testis tissue under a microscope and view a video about fertility preservation, as well as learning more about the impact of obesity in pregnancy and how the Metabolic Antenatal Clinic offers multi-disciplined support from doctors, midwives and dieticians to help support pregnant women.
Year(s) Of Engagement Activity 2019
 
Description MS Frontiers, Bath, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Irene Molina, postdoc Lindsey Forbes, and Veronique Miron presented at the MS Frontiers meeting in Bath.
Year(s) Of Engagement Activity 2019
 
Description Male contraception put to the test in Manchester and Edinburgh, Manchester and Edinburgh 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact Couples in Edinburgh and Manchester are being invited to take part in a ground-breaking international study trialling a new form of male contraception. The study is being co-lead by Richard Anderson, from the University of Edinburgh's MRC Centre of Reproductive Health, along with staff from Saint Mary's Hospital and Manchester University NHS Foundation Trust group.
Year(s) Of Engagement Activity 2019
 
Description Medical breakthrough could help cancer patients have children, ITV media interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Dr Rod Mitchell was interviewed for his expert opinion on ITV News at Ten and The Daily Mail newspaper following the first live birth of a primate after its transplantation of prepubertal testicular tissue.
Year(s) Of Engagement Activity 2019
 
Description Metastasis and the Tumor Microenvironment 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaker Major symposium 'Mestastasis and the Tumor Microenvironment', 2017 Annual Meeting of the American Association for Cancer Research, Washington USA.
Year(s) Of Engagement Activity 2017
 
Description Miami Winter Symposium 2016 'Inflammation' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Sessions focussed on the impact of inflammation on cardiovascular metabolism, nervous system, and cancer
Year(s) Of Engagement Activity 2016
 
Description Minister of Public Health and Sport visits Tommy s Metabolic Clinic 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Linked to Obesity consultation period
Year(s) Of Engagement Activity 2017
 
Description Monocyte/Macrophage/DC: tissue interaction talk at Erasmus, University Medical Center, Rotterdam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Jeff Pollard gave the Keynote talk at the "Monocyte/Macrophage/DC- tissue interaction" symposia at the Erasmus, University Medical Center, Rotterdam on 20th December followed by a workshop to students on the 21st.
Year(s) Of Engagement Activity 2018
 
Description NIHR Respiratory Biomedical Research Unit, Royal Brompton Hospital London; Fibrosis Research Group, Inflammation, Repair & Development Section 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Distinguished Guest Lecture/Assessor.
Year(s) Of Engagement Activity 2016
 
Description New project to beat 'hidden' disease puts patients at its heart 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Women with endometriosis - a painful, debilitating disease linked to infertility - are being invited to join a research project that aims to shape possible future treatments.
The initiative will team up women with endometriosis, carers, and healthcare professionals to prioritise areas of research they believe have not yet been tackled.
The project's aim is to identify the top ten leading challenges that women with endometriosis face, with a view to influence the prioritisation of future research in this area.
Endometriosis affects an estimated 176 million women. It occurs when tissue similar to the lining of the uterus is found elsewhere - most commonly in the abdomen, on the ovaries, bladder and bowel.

This misplaced tissue behaves like the lining of the uterus, bleeding every month and creating local inflammation. It is associated with chronic pain, heavy bleeding, and infertility, and can impact on mental, and social wellbeing.
Anyone affected by endometriosis - patients, carers, employers and professionals - is invited to contribute to the project through a survey which can be found here:
Endometriosis priority-setting survey
The project is being run in partnership with the James Lind Alliance, and is supported by the World Endometriosis Research Foundation (WERF).
Professor Andrew Horne, who is leading the research at the University of Edinburgh's MRC Centre for Reproductive Health, said: "Endometriosis is as common in women as diabetes and asthma, and yet it fails to attract the same attention, support and funding as those diseases.
"It is important that we ensure medical researchers are focussing on the issues that really matter for women living with this debilitating condition, and deliver treatments that make a genuine difference to their quality of life."
Year(s) Of Engagement Activity 2016
 
Description Organiser - 4th Annual Symposia. 'A cell for all seasons, Macrophages in health and disease'. Edinburgh 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Annual "Macrophage" meeting to highlight the diversity of research in this area drawing upon local and international speakers.
Year(s) Of Engagement Activity 2018
URL https://www.ed.ac.uk/centre-reproductive-health/news-events-seminars/events/a-cell-for-all-seasons-m...
 
Description Painkillers in pregnancy 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Pregnant women who take common painkillers could unwittingly be putting the fertility of their unborn daughters at risk, a study suggests.
Year(s) Of Engagement Activity 2016
 
Description Paracetamol use in pregnancy can cut female fertility, study finds 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Using painkillers in pregnancy may reduce fertility in subsequent generations, research suggests.

Tests in rats found that when a mother was given painkillers during pregnancy, her female offspring had fewer eggs, smaller ovaries and smaller litters of babies than those not exposed to the drugs.

Exposed male offspring were also found to be affected at birth - showing smaller numbers of cells that give rise to sperm in later life. However, their reproductive function recovered to normal levels by the time they reached adulthood.

Researchers say the findings are significant given the similarities between the reproductive systems of rats and humans, although it is difficult to directly extrapolate these results to pregnant women.

The team recommends that pregnant women should stick with current guidelines to use painkillers at the lowest possible dose, for the shortest possible time.

Scientists tested the effects of two painkillers in pregnant rats - paracetamol and a prescription-only painkiller called indomethacin, which belongs to the same class of drugs as ibuprofen and aspirin.

Rats were given the drugs over the course of several days - four days for indomethacin or nine days for paracetamol. The effects of the drugs were seen within one to four days of the start of treatment. Scientists say that because the pace of foetal development in humans is slower than it is in rats, it is hard to say from this study how this would translate in human use.

In addition to affecting a mother's immediate offspring, the study showed that painkillers taken in pregnancy also affected the subsequent generation of rats.

The team found that the resulting females - the granddaughters of the mother given painkillers in pregnancy - also had reduced ovary size and altered reproductive function.

Scientists say the results suggest that some painkillers may affect the development of the cells that give rise to eggs and sperm - called germ cells - while a foetus is in the womb.

This may be because the painkillers act on hormones called prostaglandins. These are known to regulate female reproduction and control ovulation, the menstrual cycle and the induction of labour.
The study has been published in the journal Scientific Reports. It was funded by the Medical Research Council and the Wellcome Trust.

Prof Richard Sharpe, who co-led the study at the University of Edinburgh's MRC Centre for Reproductive Health, said the results follow previous research that indicates painkillers should be used with caution during pregnancy.

He said: "It's important to remember that this study was conducted in rats not humans, however, there are many similarities between the two reproductive systems. We now need to understand how these drugs affect a baby's reproductive development in the womb so that we can further understand their full effect."

Prof Richard Anderson, Elsie Inglis Professor of Clinical Reproductive Science at the University of Edinburgh, who co-led the study, said: "These studies involved the use of painkillers over a relatively long period. We now need to explore whether a shorter dose would have a similar effect, and how this information can be usefully translated to human use."
Year(s) Of Engagement Activity 2016
 
Description Pint of Science Event - Richard Sharpe 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public engagement event
Year(s) Of Engagement Activity 2017
 
Description Pint of Science Event - male fertility 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Awareness of male infertility
Year(s) Of Engagement Activity 2017
 
Description Postpartum Intrauterine Contraception (PPIUC), Lothian 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Michelle Cooper presented work on Postpartum Intrauterine Contraception (PPIUC) provision in Lothian at the Scottish RCOG Senior Staff meeting in Dunblane 22-23rd Feb, and won the prize for best trainee presentation.
Year(s) Of Engagement Activity 2019
 
Description Pre-term birth clinic launch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Launch of pre-term birth clinic
Year(s) Of Engagement Activity 2018
 
Description Progress Educational Trust event, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Colin Duncan appeared on the panel for the 2019 Progress Educational Trust event.
Year(s) Of Engagement Activity 2019
 
Description Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Dr Rod Mitchell has received media wide attention after the publication of the following Research Article:
FETAL DEVELOPMENT
Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model
Year(s) Of Engagement Activity 2016
 
Description Public Lecture: Preterm Birth: Can we do better? (Lecture series) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Lecture series
Year(s) Of Engagement Activity 2017
 
Description Q&A discussion, European Interagency Security Forum 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Prof Andrew Horne and Prof Philippa Saunders led a roundtable discussion and extensive Q and A with members of the public about endometriosis.
Year(s) Of Engagement Activity 2019
 
Description Quiz a Whiz, Royal Society of Edinburgh, Edinburgh 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Hilary Critchley further addressed the need to more openly discuss the topic of menstruation in her online RSE event 'Quiz a Whiz'.
Year(s) Of Engagement Activity 2019
 
Description RAIDS European Consortium, Institut Curie, Paris, France 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact RAIDs is a multidisciplinary co-operation between academic clinical centers, Small medium enterprises and translational research platforms. It combines Next Generation Sequencing (NGS) and Reverse Phase Protein array (RPPA) in a large patient population prior to standard therapy.
In addition, high throughput screening techniques have been performed in Cervical Cancer cell lines, allowing to identify new drugs of relevance for advanced stage multi resistant Cervical Cancer. These molecules are to be validated in preclinical mouse models. Ongoing studies will assess in vitro efficacy of drug targeting according to molecular phenotypes.
Year(s) Of Engagement Activity 2017
URL http://www.raids-fp7.eu/project-overview.html
 
Description RCOG careers day, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Sarah Murray led the instrumental delivery workshop at the RCOG careers day in London as part of her role as Vice Chair of the National Trainees Committee. Over 300 delegates attended the event to learn about obstetrics and gynaecology as a career and have a go at some of the practical aspects of the job.
Year(s) Of Engagement Activity 2019
 
Description Reproductive Biology Research Talk, James Gillespie High School, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact John Reynolds-Wright gave a talk about abortion to high school students at James Gillespie High School.
Year(s) Of Engagement Activity 2019
 
Description Research Roundup: Gum Disease and Alzheimer's, a Cancer Vaccine, Cold Plasma and More, BioSpace Website 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Jeff Pollard was quoted in an article "Research Roundup: Gum Disease and Alzheimer's, a Cancer Vaccine, Cold Plasma and More" by the BioSpace website.
Year(s) Of Engagement Activity 2019
 
Description School visit x 1 (Mary Erskine) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact School visit led by Andrew Horne
Year(s) Of Engagement Activity 2017
 
Description School visit x 2 (The Edinburgh Academy) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact School visit by Colin Duncan
Year(s) Of Engagement Activity 2017
 
Description Science Insights 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Lab experience for students
Year(s) Of Engagement Activity 2017
 
Description Science at the Interface of Industry, Institute of Genetics & Molecular Medicine, Edinburgh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Aleks Tsolova attended the workshop 'Science at the Interface of Industry' organised by the IGMM. As part of the workshop, attendees were split into 4 teams and tasked to come up with a business idea, develop a business plan and pitch their idea to a "Dragons Den" style panel composed of top scientists working across biotech and the entrepreneurial industry. Aleks and her team of three had the idea of creating a community of mental health first aiders across the University.
Year(s) Of Engagement Activity 2019
 
Description Society for Reproductive Investigation, Paris 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Erin Greaves presented a poster entitled 'Phenotypic Characterisation of Lesion-resident and Peritoneal Macrophages in a Mouse Model of Endometriosis' at the Society for Reproductive Investigation in Paris.
Year(s) Of Engagement Activity 2019
 
Description Speaker - 10th Workshop of European Network of Breast Development and Cancer Labs (ENBDC) Switzerland 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Tumour immunology : Macrophage maleficence in cancer.
Year(s) Of Engagement Activity 2018
URL http://www.enbdc.org/
 
Description Speaker - 1st Crick International Cancer Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact leading cancer scientists from all over the world discussing the latest findings in cancer metabolism, the tumour microenvironment, and how the cancer genotype changes over time.
Year(s) Of Engagement Activity 2017
URL https://www.crick.ac.uk/whats-on/seminars-lectures-symposia/symposia
 
Description Speaker - CRUK Marshall Symposium, Climping UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Lecture in cancer biology/medicine
Year(s) Of Engagement Activity 2018
 
Description Speaker - Cold Spring Harbor Asia Conference, Suzhou, China 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference covering the latest findings across many topics in RNA modifications & Eptranscriptomics.
Year(s) Of Engagement Activity 2017
 
Description Speaker - International Symposium of Cancer Immunity and Immunotherapy, Japan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Symposia on cutting-edge topics in current immunology at 46th Annual Meeting of the JSI, Sendai, Japan.
Year(s) Of Engagement Activity 2017
URL http://icongroup.co.jp/immunology/english/greeting/
 
Description Speaker, 2018 Mammalian Reproduction Gordon Research Conference, Lucca, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lecture on Kruppel-Like Transcription Factors as Downstream Modulators of Female Sex Steroid Hormone Action in the Uterus.
Year(s) Of Engagement Activity 2018
 
Description Speaker, 2nd Annual Next Gen Immuno-Oncology Congress, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The congress aims to bring academicians, researchers and scientists from research institutes pharmaceutical, bio-pharmaceutical and biotechnology companies to discuss the latest updates in the development of ADC's, Bispecific Antibodies and Immune Checkpoint Inhibitors.
Year(s) Of Engagement Activity 2018
URL http://www.mnmconferences.com/2nd-Annual-Next-Gen-Immuno-Oncology-Congress
 
Description Speaker, 32nd Annual 'Genes and Cancer' meeting, Robinson College, Cambridge, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Genes and Cancer' is a broad-based research meeting focusing on basic and translational cancer research. The meeting is one of the UK and Europe's best cancer research meetings and the meeting is now in its 33rd year. This year's event is focused on four main research themes. They are: 'Gene Regulation in Cancer', 'Ubiquitin Signalling and Inflammation', 'Tumour Metabolism' and 'Model Organisms in Cancer Research'. In addition to these 4 themes there will be a Keynote lecture and short talks will be chosen from submitted abstracts (including short talks for junior principal investigators and short talks for post-docs/students). The main aim of the meeting is to bring together young scientists with some of the world's leaders in cancer research in an informal environment that maximizes interaction between speakers and delegates.
Year(s) Of Engagement Activity 2017
 
Description Speaker, 8th Abercrombie Meeting, Royal Microscopical Society, St Catherine's College, Oxford UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Research and education in microscopy, and enabling microscopists to make advances and developments in microscopy, cytometry and imaging.
Year(s) Of Engagement Activity 2017
URL https://www.rms.org.uk/
 
Description Speaker, ISREC SCC Symposium 2018, Lausanne, Switzerland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Topics covered included all of the hallmarks of cancer, with a focus on tumor immunology and mechanism guided therapies.
Year(s) Of Engagement Activity 2018
 
Description Speaker, VIB Macrophage Symposium, Vrije University, Brussels 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Bringing together leaders in the macrophage field as well as pioneers of novel single-cell technologies.
Year(s) Of Engagement Activity 2017
 
Description Sperm grown in lab 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Professor Sharpe offered a quote through Science Media Centre on this particular study.
Year(s) Of Engagement Activity 2016
URL http://www.telegraph.co.uk/news/science/science-news/12173317/Sperm-grown-in-lab-could-allow-inferti...
 
Description St Andrews Cancer Colloquium, UK 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A group of top cancer researchers and clinical oncologists from the USA, Italy, Canada and the UK took part in The Cancer Colloquium, hosted by the University's School of Medicine.
Year(s) Of Engagement Activity 2017
 
Description St Andrews Day Thank you to all CRUK supporters in Scotland 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CRUK in Scotland and Prof Pollard also filmed a special thank you on St Andrew's Day to 'the extraordinary generosity' of those who have supported their research and have helped make a significant difference to the survival of cancer patients.
Year(s) Of Engagement Activity 2019
URL https://twitter.com/CRUKScotland/status/1200714334554525697/video/1
 
Description Stress & Inflammation in Tumor Progression & Metastasis conference, Weizman Institute, Israel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact On 13 May, Jeff Pollard gave a talk called "Macrophages; Bad actors in human and mouse cancer" at the Stress & Inflammation in Tumor Progression & Metastasis conference at the Weizman Institute in Israel. Globally, the Institute is one of the highest ranking multidisciplinary scientific research institutes. It also educates much of Israel's scientific leadership and involved in science literacy public engagement activities with schools and the general public.
Year(s) Of Engagement Activity 2019
 
Description Stress & Inflammation in Tumor Progression & Metastasis, Weizman Institute, Israel 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Jeff Pollard gave a talk at the Stress & Inflammation in Tumor Progression & Metastasis conference at the Weizman Institute in Israel.
Year(s) Of Engagement Activity 2019
 
Description Sun Yat-Sen Memorial Hall, Japan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Macrophage maleficence in cancer
Year(s) Of Engagement Activity 2017
 
Description Tea and Just talk, The Royal Society of Edinburgh, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Varsha Jain and Hilary Critchley held an open discussion about menstruation, highlighting their research focus on enhancing understanding of this
area.
Year(s) Of Engagement Activity 2019
 
Description The Human Papillomavirus (HPV) Research Group, 19th Scottish HPV Investigators Network, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Dr Tim Palmer presented his data in the 19th Scottish HPV Investigators Network, showing a reduction in precancerous disease in women attending for their second screen, even when their first smear was abnormal, and for the first-time evidence that the number of cancers in immunised women is lower.

Dr Kevin Pollock also presented in the event about HPV vaccine hesitancy, particularly about while uptake of vaccine has been over 80% in Scotland since 2008, there is no room for complacency. Other countries have been "hit" by anti-HPV vaccine messages (including on social media) which can have a significant and rapid impact on the vaccination programme as a consequence of perceived safety issues (e.g. Japan's coverage dropped from 70% to 1%, Ireland's from 80% to 50%).
Year(s) Of Engagement Activity 2019
 
Description The Jennifer Brown Research Laboratory celebrates 15 years of saving lives 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Professor Sir John Savill welcomed guests and we celebrated past achievements during presentations from Sarah and Gordon Brown, and Professor Andrew Calder and Dr Ian Laing who were founder members of the JBRL.

Dr James Boardman, scientific director of the JBRL, gave a presentation about current and future work of the laboratory and the Theirworld Edinburgh Birth Cohort (TEBC), which is a new initiative designed to improve life course outcome after perinatal brain injury caused by preterm birth and / or sub-optimal growth in utero. The TEBC places patients at the centre of a research journey that encompasses medicine, imaging, biology, education and socio-economics, to deliver new understanding of, and accelerate the translation of treatment for, perinatal brain injury.

We were honoured to listen to the parent perspective given by Catherine Smith, daughter of the late Labour leader John Smith. Catherine delivered her baby daughter at 28 weeks' gestation and she gave powerful testimony to the importance of perinatal research for driving improvements in care. We were delighted to be joined by family participants in our research, and by senior members of the University's academic community who represent a diverse field of expertise, thereby reflecting the interdisciplinary nature of the work of the JBRL.
Year(s) Of Engagement Activity 2016
 
Description The MRC's Festival of Medical Research, Edinburgh 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Students from both Portobello High and Preston Lodge High School toured around the MRC centre. Rod Mitchell introduced the group to the Centre's latest research in fertility preservation. Students were also assisted throughout the day with activities and their questions answered by many of the Centre's talented research fellows and PhD students
Year(s) Of Engagement Activity 2019
 
Description The Scottish Sun Online launches endometriosis awareness campaign Endo Period Stigma 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Andrew Horne was featured on the The Sun campaign to encourage employers to support employees with endometriosis.
Year(s) Of Engagement Activity 2019
 
Description The Sun, United Kingdom 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Philippa Saunders was invited to talk to The Sun about endometriosis.
Year(s) Of Engagement Activity 2019
 
Description Therapy to stop premature birth safe but ineffective, study finds 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A therapy widely recommended in the UK, Europe and the US to stop babies from being born too soon is ineffective, research shows.
The treatment does not appear to pose any harm to mother or baby but has no effect on preventing an early birth, the findings reveal.
Researchers say that use of the medicine should be reviewed. They also call for a re-doubling of efforts to find alternative interventions to prevent premature births.
Previous research suggested that the therapy - a hormone called progesterone - may stop pregnant women from giving birth early but little was known about its long term effects.
This latest trial - involving more than 1200 women - is the largest to assess the effects of the treatment on women and the first to study its effects in babies born after the therapy.
Researchers focused on women who are considered to have a greater risk of premature delivery - either because they have previously delivered a baby early or have lost a baby late in pregnancy.
Around a half of the women were given progesterone and the others were given a dummy pill.
The team found that whilst the therapy appeared to be safe, it did not reduce the risk of premature delivery and offered no notable health benefits for mother or baby.
More than 64 hospitals from around the UK were involved in the research, which was led by the Tommy's Centre for Maternal and Fetal Health at the University of Edinburgh.
The study is published in The Lancet. It was funded by the Efficacy and Mechanism Evaluation (EME) Programme, a partnership between the Medical Research Council and National Institute for Health Research.
Professor Jane Norman, Director of the Tommy's Centre for Maternal and Fetal Health at the University of Edinburgh, said: "Babies born too early have a much greater risk of short-term and long-term health problems. We need to find new strategies that help mums carry their babies to term."
Year(s) Of Engagement Activity 2016
 
Description Tommy Sheppard visit to CRH (part of parliamentary scheme) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Part of parliamentary scheme
Year(s) Of Engagement Activity 2017
 
Description Tumour Infiltrating Myeloid Cell Compartment Symposium, Leiden University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote speaker : Tumour associated macrophages: from mechanism to therapy
Year(s) Of Engagement Activity 2016
URL http://www.timcc.eu/?page_id=629
 
Description University of Edinburgh Neuroscience Day, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Irene Molina and Amy Lloyd presented posters at University of Edinburgh Neuroscience Day on their work on brain repair.
Year(s) Of Engagement Activity 2019
 
Description Video Pregnant and obese: The clinic trying to help, BBC Breakfast News 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Fiona Denison and her maternal health team were featured on BBC Breakfast showcasing the multidisciplinary care they offer to women carrying too much weight during pregnancy.
Year(s) Of Engagement Activity 2019
 
Description Weizmann Institute of Science Life Sciences Colloquium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Macrophage Maleficence in Cancer
Year(s) Of Engagement Activity 2018
 
Description Wellcome Researcher's meeting : Molecular Mechanisms, Immunology and Parasitology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Speaker
Year(s) Of Engagement Activity 2016
 
Description Wellcome researchers' "Physiology and Cell Biology", Hinxton, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Jeff Pollard presented at the Wellcome researchers' "Physiology and Cell Biology" meeting in Hinxton, Cambridge.
Year(s) Of Engagement Activity 2019
 
Description Women in Science in Scotland, The Royal Society of Edinburgh, Edinburgh 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Prof Hilary Critchley is interviewed and featured on 'The Women in Science in Scotland' exhibition.
Year(s) Of Engagement Activity 2019
 
Description invited presentation at Gordon Research Seminar: Glia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Irene Molina, a final year PhD student, presented her work on astrocytes and brain repair as an invited oral presentation at the Gordon Research Seminar: Glia, and as a poster at the Gordon Research Conference.
Year(s) Of Engagement Activity 2019