A new noradrenergic strategy to treat Impulsivity in Progressive Supranuclear Palsy
Lead Research Organisation:
University of Cambridge
Department Name: Clinical Neurosciences
Abstract
Progressive Supranuclear Palsy (PSP) is as complex as it is devastating for patients and families, combining a kind of movement disorder that does not respond to standard therapies, choking, loss of speech, personality changes, and dementia. Research by our team has shown that in the UK around 7,000 people are living with PSP.
Although physically very disabling, it is cognitive and personality changes in PSP that have the greatest impact on quality of life. Despite being slow and unresponsive for many activities, the same patients are often reckless and impulsive for actions that they do make. For example, a person living with PSP may "rush into things" and or "jump to conclusions" without thought for the consequences, or behave in a way that has high risks of falls or choking. These problems are also called "impulsivity". Impulsivity is highly dangerous for patients with PSP, in several different ways. It can make patients walking or moving around alone even though they have a very poor balance and fall. Eating too fast while choking is another form of impulsive behaviour which can lead to life-threatening chest infections. Impulsivity can also be highly distressing for carers and families.
There is currently no cure for PSP, although some of the symptoms, including impulsivity, are potentially treatable. However, there is yet a big gap between our knowledge of what is happening in brain cells of patients with PSP and how we should use the available treatments to help people with PSP to achieve the best possible quality of life. We must therefore build better "bridges" between basic studies and clinical trials.
To do this, our team will run a series of studies using the most advanced technologies in basic and clinical neuroscience, using advances in imaging, pharmacology, and psychology.
We will take advantage of the link between a brain chemical, noradrenaline, and the control of behavior. Noradrenaline is made by a tiny region of the brain called the locus coeruleus. It acts on other parts of the brain, especially the frontal lobe, to help control behavior, including flexible thinking and action control.
First, we will quantify the changes in the locus coeruleus, in PSP patients who we have followed through their illness in clinic and who then donated their brain to the Cambridge Brain Bank.
Second, we will measure the locus coeruleus in living patients with PSP. The locus coeruleus is small, and hard to see with normal brain scans. Working with Prof Emrah Duzel from Magdeburg, we will use the new technology of ultra-high field magnetic resonance imaging (known as "7 Tesla") to measure the size and degeneration of the locus coeruleus. His groups have developed new robust tools to measure this brain region. We will then use functional magnetic resonance imaging to measure how well the locus coeruleus connects to the frontal lobe and other brain regions.
Finally, we will measure the effects of a specific drug that enhances noradrenaline (called "atomoxetine") on impulsvity and cognition in PSP. This drug has been shown by our group and collaborators to improve impulsivity in a significant proportion of patients with Parkinson's disease, and in animal models of impulsivity. It is well tolerated, and approved for such research use in PSP. We believe that the results of our study will lead on to clinical trials for impulsivity in PSP and will eventually contribute to enhance the quality of life of people suffering from PSP.
Although physically very disabling, it is cognitive and personality changes in PSP that have the greatest impact on quality of life. Despite being slow and unresponsive for many activities, the same patients are often reckless and impulsive for actions that they do make. For example, a person living with PSP may "rush into things" and or "jump to conclusions" without thought for the consequences, or behave in a way that has high risks of falls or choking. These problems are also called "impulsivity". Impulsivity is highly dangerous for patients with PSP, in several different ways. It can make patients walking or moving around alone even though they have a very poor balance and fall. Eating too fast while choking is another form of impulsive behaviour which can lead to life-threatening chest infections. Impulsivity can also be highly distressing for carers and families.
There is currently no cure for PSP, although some of the symptoms, including impulsivity, are potentially treatable. However, there is yet a big gap between our knowledge of what is happening in brain cells of patients with PSP and how we should use the available treatments to help people with PSP to achieve the best possible quality of life. We must therefore build better "bridges" between basic studies and clinical trials.
To do this, our team will run a series of studies using the most advanced technologies in basic and clinical neuroscience, using advances in imaging, pharmacology, and psychology.
We will take advantage of the link between a brain chemical, noradrenaline, and the control of behavior. Noradrenaline is made by a tiny region of the brain called the locus coeruleus. It acts on other parts of the brain, especially the frontal lobe, to help control behavior, including flexible thinking and action control.
First, we will quantify the changes in the locus coeruleus, in PSP patients who we have followed through their illness in clinic and who then donated their brain to the Cambridge Brain Bank.
Second, we will measure the locus coeruleus in living patients with PSP. The locus coeruleus is small, and hard to see with normal brain scans. Working with Prof Emrah Duzel from Magdeburg, we will use the new technology of ultra-high field magnetic resonance imaging (known as "7 Tesla") to measure the size and degeneration of the locus coeruleus. His groups have developed new robust tools to measure this brain region. We will then use functional magnetic resonance imaging to measure how well the locus coeruleus connects to the frontal lobe and other brain regions.
Finally, we will measure the effects of a specific drug that enhances noradrenaline (called "atomoxetine") on impulsvity and cognition in PSP. This drug has been shown by our group and collaborators to improve impulsivity in a significant proportion of patients with Parkinson's disease, and in animal models of impulsivity. It is well tolerated, and approved for such research use in PSP. We believe that the results of our study will lead on to clinical trials for impulsivity in PSP and will eventually contribute to enhance the quality of life of people suffering from PSP.
Technical Summary
Impulsivity is a distressing and injurious aspect of PSP that is commonly under-recognised and poorly managed, even when coupled with balance and swallowing difficulty, with high risk of falls, injury, and choking. It typically coexists with apathy and bradykinesia, and is not relieved by current dopaminergic therapies. Impulsivity is a complex construct, with dissociable pharmacological and anatomical mechanisms that impair response inhibition, reward sensitivity, and decision making. Our group and collaborators have provided robust evidence that response inhibition in patients with Parkinsonian disorders linked to PSP (e.g., Parkinson's disease and frontotemporal dementia) is modulated by noradrenaline (NA), a key neurotransmitter mainly synthesized by the locus coeruleus (LC). Our overarching hypothesis is that enhancing NA function via NA reuptake inhibitors can improve response inhibition and impulsivity in PSP patients, mediated by the prefrontal cortex and its connections to the caudate and subthalamic nucleus.
This study will: (1) provide new quantitative evidence for the degree of loss of neurons in the LC, using post-mortem samples from PSP patients whom we have followed over the last 10 years; (2) apply advances in ultra-high-field MRI to quantify the LC in living PSP patients, together with a battery of behavioural tests of impulsivity and neuropsychology; (3) use formal models of behavior to track decision variables behind impulsive actions, and relate these to neural and disease markers, including brain network connectivity, and (4) test a repurposed drug, atomoxetine, to restore core neurocognitive systems governing the inhibition of motor responses in PSP.
Our work will promote bidirectional translational research, between non-clinical and clinical neuroscience, mapping disease states to preclinical models of cognition and behavior; and guide subsequent clinical trials with better outcome measures and patient selection and stratification.
This study will: (1) provide new quantitative evidence for the degree of loss of neurons in the LC, using post-mortem samples from PSP patients whom we have followed over the last 10 years; (2) apply advances in ultra-high-field MRI to quantify the LC in living PSP patients, together with a battery of behavioural tests of impulsivity and neuropsychology; (3) use formal models of behavior to track decision variables behind impulsive actions, and relate these to neural and disease markers, including brain network connectivity, and (4) test a repurposed drug, atomoxetine, to restore core neurocognitive systems governing the inhibition of motor responses in PSP.
Our work will promote bidirectional translational research, between non-clinical and clinical neuroscience, mapping disease states to preclinical models of cognition and behavior; and guide subsequent clinical trials with better outcome measures and patient selection and stratification.
Planned Impact
The beneficiaries of our research will extend beyond the academic environment and will include:
1. Patients with PSP: Impulsivity in PSP represents a significant burden to the affected individuals. PSP patients with problems as impulsivity and cognitive inflexibility have an increased risk of falls, injuries, chocking episodes, aspiration pneumonia, and early death. It is hoped that increasing our understanding into the brain mechanisms of impulsivity in PSP will reduce these risks. The absence of biomarkers for detecting impulsivity in PSP and the high inter-patients variability in drug response have also made the treatment of behavioural problems in PSP and other neurodegenerative disorders a major challenge. The cause of this variability in treatment response remains largely unclear, although heterogeneity in core neurochemical systems that determines a reduced sensitivity to specific therapy may play a significant role. Brain-based mechanistic accounts of impulsivity in PSP could therefore help clinical decision making and improve the management of these disabling behavioural symptoms in PSP and related disorders.
1. Non-academic clinicians: Our findings may provide useful information for clinical neurologists and other professionals who work with PSP patients (e.g., speech and language therapists, physiotherapists, and specialist nurses) and will raise awareness on a common and too often under-recognized problem in PSP. In particular, our project will reveal: (1) why some patients with PSP display impulsive behaviours and behavioral problems; (2) what happens to the brain of PSP patients with impulsive behaviours, and (3) that there are potential targets for treating impulsivity in PSP (i.e., via enhancing the noradrenergic system).
2. Carers of patients with PSP: Parents, relatives, friends, social workers, and other carers of people with PSP may also benefit from our research. In the short term our project may have a positive effect by, for example, helping carers understand PSP and its associated problems better. In the longer term, it is hoped that our results will translate into clinical trials that will provide better treatments for managing challenging behavioural syndromes in PSP.
3. Other neurodegenerative disorders: PSP is a complex disorder that share some molecular, pathophysiological, and clinical features with other neurological disorders such as Parkinson's disease, Huntington's disease, and frontotemporal dementia. Taken together, these neurodegenerative disorders represent a very significant burden to society. We therefore hope that research enabling the development of more effective interventions to manage behavioral syndromes in PSP could be also applicable to other common neurodegenerative disorders.
1. Patients with PSP: Impulsivity in PSP represents a significant burden to the affected individuals. PSP patients with problems as impulsivity and cognitive inflexibility have an increased risk of falls, injuries, chocking episodes, aspiration pneumonia, and early death. It is hoped that increasing our understanding into the brain mechanisms of impulsivity in PSP will reduce these risks. The absence of biomarkers for detecting impulsivity in PSP and the high inter-patients variability in drug response have also made the treatment of behavioural problems in PSP and other neurodegenerative disorders a major challenge. The cause of this variability in treatment response remains largely unclear, although heterogeneity in core neurochemical systems that determines a reduced sensitivity to specific therapy may play a significant role. Brain-based mechanistic accounts of impulsivity in PSP could therefore help clinical decision making and improve the management of these disabling behavioural symptoms in PSP and related disorders.
1. Non-academic clinicians: Our findings may provide useful information for clinical neurologists and other professionals who work with PSP patients (e.g., speech and language therapists, physiotherapists, and specialist nurses) and will raise awareness on a common and too often under-recognized problem in PSP. In particular, our project will reveal: (1) why some patients with PSP display impulsive behaviours and behavioral problems; (2) what happens to the brain of PSP patients with impulsive behaviours, and (3) that there are potential targets for treating impulsivity in PSP (i.e., via enhancing the noradrenergic system).
2. Carers of patients with PSP: Parents, relatives, friends, social workers, and other carers of people with PSP may also benefit from our research. In the short term our project may have a positive effect by, for example, helping carers understand PSP and its associated problems better. In the longer term, it is hoped that our results will translate into clinical trials that will provide better treatments for managing challenging behavioural syndromes in PSP.
3. Other neurodegenerative disorders: PSP is a complex disorder that share some molecular, pathophysiological, and clinical features with other neurological disorders such as Parkinson's disease, Huntington's disease, and frontotemporal dementia. Taken together, these neurodegenerative disorders represent a very significant burden to society. We therefore hope that research enabling the development of more effective interventions to manage behavioral syndromes in PSP could be also applicable to other common neurodegenerative disorders.
Organisations
- University of Cambridge (Lead Research Organisation)
- University of Gothenburg (Collaboration)
- University of Cambridge (Collaboration)
- University of Copenhagen (Collaboration)
- Ferrer Internacional (Collaboration)
- University of Toronto (Collaboration)
- UNIVERSITY OF YORK (Collaboration)
- VU University Medical Center (Collaboration)
- University of California, San Francisco (Collaboration)
- The Otto-von-Guericke University Magdeburg (Collaboration)
- Van Andel Institute (Collaboration)
- University College London (Collaboration)
- McGill University (Collaboration)
- National Institute for Health and Care Research (Collaboration)
- Boostec (Collaboration)
- Cardiff University (Collaboration)
- Alector (Collaboration)
- Irish Critical Care Clinical Trials Network (Collaboration)
- International Parkinson and Movement Disorder Society (MDS) (Collaboration)
- Ludwig Maximilian University of Munich (LMU Munich) (Collaboration)
- Cambridge University Hospitals NHS Foundation Trust (Project Partner)
Publications
Adams N
(2023)
Neurophysiological consequences of synapse loss in progressive supranuclear palsy
in Brain
Azevedo T
(2022)
A deep graph neural network architecture for modelling spatio-temporal dynamics in resting-state functional MRI data.
in Medical image analysis
Azevedo T
(2020)
A deep spatiotemporal graph learning architecture for brain connectivity analysis.
in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Betts MJ
(2019)
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.
in Brain : a journal of neurology
| Title | Concert for dementia and Parkinson's research at Jesus College - Conversation with James B Rowe |
| Description | Concert for dementia and Parkinson's research at Jesus College Jesus College recently hosted a concert for dementia and Parkinson's disease research at the University of Cambridge, led by Professor Matt Lambon-Ralph, Director of the MRC Cognition and Brain Sciences Unit. The event highlighted the current understanding of and research into treating dementia and Parkinson's disease, with musical interludes providing space for calm reflection. Professor Lambon-Ralph opened the evening with a warm welcome, encouraging the audience to consider the experience of dementia and Parkinson's by outlining the symptoms of the diseases. |
| Type Of Art | Performance (Music, Dance, Drama, etc) |
| Year Produced | 2024 |
| Impact | Jesus College recently hosted a concert for dementia and Parkinson's disease research at the University of Cambridge, led by Professor Matt Lambon-Ralph, Director of the MRC Cognition and Brain Sciences Unit. The event highlighted the current understanding of and research into treating dementia and Parkinson's disease, with musical interludes providing space for calm reflection. |
| URL | https://www.jesus.cam.ac.uk/articles/concert-dementia-and-parkinsons-research-jesus-college |
| Title | Painting by Alan Rogerson |
| Description | Alan Rogerson attended the talk by Dr Luca Passamonti in 2018, where Luca discussed PSP and the methods of PET to study this disease. Alan draw an artistic inspiration from Luca's talk and in result produced the painting. |
| Type Of Art | Artwork |
| Year Produced | 2018 |
| Impact | As above. |
| Title | Pint of Science |
| Description | Pint of Science festival presentations in pubs, bringing research progress and ideas to the public. |
| Type Of Art | Performance (Music, Dance, Drama, etc) |
| Year Produced | 2018 |
| Impact | Wide public interest -sell out events |
| Description | 10 Downing Street Launch of Dementia Mission |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | DPUK Director John Gallacher (PhD AFBPsS CPsychol FFPH) and DPUK Associate Directors Vanessa Raymont and James Rowe came together alongside charities, investors, industry and people living with or caring for those with dementia to accelerate efforts to tackle the disease. Obtaining and using complex data, speeding up clinical trials and the importance of biomarkers all support the mission to develop innovative research tools to tackle dementia. The mission provides a great opportunity for the UK to build at pace and scale and deliver meaningful change for people living with or at risk of this cruel disease. |
| URL | https://www.dementiasplatform.uk/news-and-media/latest-news/dpuk-at-no-10-to-support-dame-barbara-wi... |
| Description | Cambridge Dementia Course |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | http://www.cambridgedementiacourse.com/index.html |
| Description | Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria (May 2017). |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.26987 |
| Description | Control Processes Meeting |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or improved professional practice |
| Impact | Control processes |
| Description | DPUK Work Package Forum |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | UKRI funded programme with measured impact. |
| Description | Dr M Malpetti - Supervisor 4 PhD & MPhil Students - Department of Clinical Neurosciences (University of Cambridge) |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | training |
| Description | Dr M Malpetti Host for two international students from Ludwig Maximilian University of Munich |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Training |
| Description | Dr M Malpetti • Line manager and Supervisor of 3 research assistants |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Training of workforce |
| Description | FTDUK National Meeting |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Meeting of experts and training of researchers, engagement with public. |
| URL | https://www.ftduk.org/previous-programmes/#1727337659512-220c5b1a-1835 |
| Description | GENFI - Barcelona Meeting |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Academic and PPIE engagement. |
| Description | Guide to cognition in PSP |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | A guide to identifying and treating cognitive deficits in PSP and CBD, for the PSP- association, to educate and inform GPs and allied healthcare practitoners |
| Description | How to target good scientific problem - Dr Amirhossein Jafarian (Rowe Group) |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | PhD training |
| Description | MEG in Pharma |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Using MEG as an effective outcome measure in clinical trials. |
| Description | Medical and Health Regulatory Agency (MHRA) - Evidence on New Drugs for Dementia |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Policy workshop on UK drug landscape for Dementia. |
| Description | Prof. James B Rowe Policy national review committee (MHRA UK) |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | MHRA, UK Advisory |
| Description | Scientific Advisory Board - AI Mind International Consortium |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Training and incorporation of AI. |
| Description | Scientific Advisory Board - Dementia Mission |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | DPUK Director John Gallacher (PhD AFBPsS CPsychol FFPH) and DPUK Associate Directors Vanessa Raymont and James Rowe came together alongside charities, investors, industry and people living with or caring for those with dementia to accelerate efforts to tackle the disease. Obtaining and using complex data, speeding up clinical trials and the importance of biomarkers all support the mission to develop innovative research tools to tackle dementia. The mission provides a great opportunity for the UK to build at pace and scale and deliver meaningful change for people living with or at risk of this cruel disease. |
| URL | https://www.dementiasplatform.uk/news-and-media/latest-news/dpuk-at-no-10-to-support-dame-barbara-wi... |
| Description | Sports Concussion Research Forum Member |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | See report https://www.ukri.org/wp-content/uploads/2024/09/MRC-120924-ConcussionInSportReport.pdf |
| URL | https://www.ukri.org/wp-content/uploads/2024/09/MRC-120924-ConcussionInSportReport.pdf |
| Description | UHF Research Review in Parkinsonism |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in systematic reviews |
| Description | US Food and Drug Agency Roundtable Meeting |
| Geographic Reach | North America |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Influence on Federal Agency. |
| Description | Video on PSP diagnosis -its not parkinson s- |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Education video for healthcare workers, and GPs |
| URL | https://www.youtube.com/watch?v=JlNwrq9wb2w |
| Description | (Dr Sanne Kaalund) Dating protein aggregates in degenerative tauopathies, to model disease progression |
| Amount | £4,754 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 01/2021 |
| Description | Biomedical Research Centre Dementia Theme |
| Amount | £118,000,000 (GBP) |
| Funding ID | RG85367 |
| Organisation | National Institute for Health and Care Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2022 |
| Description | Brain Network Analysis in Neurodegenerative Tauopathies |
| Amount | £22,391 (GBP) |
| Funding ID | RG89925 |
| Organisation | The Evelyn Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2019 |
| Description | Clinical Research Fellowship |
| Amount | £279,000 (GBP) |
| Organisation | Progressive Supranuclear Palsy Association (PSPA) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2026 |
| Description | Dating protein aggregates in neurodegenerative disease |
| Amount | 1,799,000Â kr. (DKK) |
| Organisation | Lundbeck Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 03/2022 |
| End | 02/2024 |
| Description | ED Davies Scholarship (Fitzwilliam College) |
| Amount | £1,460 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 01/2023 |
| Description | Investigating the effect of deprivation in the dementia syndromes associated with frontotemporal lobar degeneration and Parkin's disease |
| Amount | £0 (GBP) |
| Funding ID | NIHR-INF-2586 |
| Organisation | National Institute for Health and Care Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2025 |
| Description | Measuring microscopic changes at the macroscopic level in frontotemporal dementia - Fellowship to Sanne S. Kaalund |
| Amount | 400,000Â kr. (DKK) |
| Funding ID | R232-2016-2333 |
| Organisation | Lundbeck Foundation |
| Sector | Charity/Non Profit |
| Country | Denmark |
| Start | 07/2017 |
| End | 07/2019 |
| Description | Progressive Supranuclear Palsy Association Small Research Grant |
| Amount | £9,279 (GBP) |
| Organisation | Progressive Supranuclear Palsy Association (PSPA) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2022 |
| Description | Restoring noradrenergic function to improve apathy in Parkinson s disease to Claire O Callaghan |
| Amount | £49,677 (GBP) |
| Funding ID | RG90797 |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2017 |
| End | 07/2018 |
| Description | SYNAPSE-FTLD: Design and delivery of clinical trials to treat challenging behaviours in the syndromes associated with frontotemporal lobar degeneration |
| Amount | £684,363 (GBP) |
| Funding ID | RAD-2023-Full 1002 |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2025 |
| End | 01/2030 |
| Description | Travel Grant |
| Amount | £1,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 11/2021 |
| Title | Cambridge Questionnaire for Apathy and Impulsivity Traits - Rebeccca Williams |
| Description | The CamQUAIT (Cambridge Questionnaire for Apathy and Impulsivity Traits) spearheaded by Claire Lansdall was finally published this year - you can find the preprint here and we're currently submitting to PLOS ONE. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | The CamQUAIT (Cambridge Questionnaire for Apathy and Impulsivity Traits) spearheaded by Claire Lansdall was finally published this year - you can find the preprint here and we're currently submitting to PLOS ONE. |
| URL | https://www.medrxiv.org/content/10.1101/2024.07.01.24309762v1 |
| Title | LC atlas |
| Description | An atlas of locus ceruleus, currently as submisison in BioRxiv and and awaiting reviewers approval in Neuroimagine. This work is led by Dr Rong Ye. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor control. The LC can be identified in vivo using non-invasive magnetic resonance imaging techniques which have potential as biomarkers for detecting and monitoring disease progression. We created a probabilistic atlas of the LC from 53 healthy older volunteers (52-84 years) using a sensitive magnetisation transfer sequence and ultrahigh field 7T MRI to investigate the LC structure in vivo at high-resolution. We would like to make the atlas available on NITRC for researchers, for replication or to facilitate accurate LC localisation and unbiased contrast extraction in future cognitive and clinical studies. |
| Description | Cambridge LMU strategic partnership |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | A new strategic partnership to build a common research framework on cognitive reserve, resilience and dementia Bilateral meetings, joint grant writing, and visiting professorships |
| Collaborator Contribution | A new strategic partnership to build a common research framework on cognitive reserve, resilience and dementia Bilateral meetings, joint grant writing, and visiting professorships |
| Impact | Internal reports and new grant proposals |
| Start Year | 2019 |
| Description | Claire O Callaghan - Restoring noradrenergic function to improve apathy in Parkinson s disease |
| Organisation | University of Cambridge |
| Department | Department of Psychiatry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Input on study design |
| Collaborator Contribution | Study design, will do data collection and analyses, publications pending |
| Impact | publications still pending |
| Start Year | 2017 |
| Description | DRCMR |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | 7T and LC imaging expertise for dementia and parkinsons |
| Collaborator Contribution | 7T and LC imaging expertise for dementia and parkinsons |
| Impact | workshop May 2025 |
| Start Year | 2024 |
| Description | Dating protein aggregates in degenerative tauopathies, to model disease progression |
| Organisation | University of York |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Intellectual idea was conveyed by Dr Sanne Kaalund. The collaboration is at the stage of Dr Kaalund sending over the extracted tau fibrils. |
| Collaborator Contribution | Prof Kirsty Penkman from York will analyse the samples to obtain racemization ratios of aminoacids. |
| Impact | Yet to be determined. |
| Start Year | 2020 |
| Description | Dr M Malpetti Bye-Fellow at Sidney Sussex College, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Sidney Sussex College, Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Promotion to bye-fellow |
| Collaborator Contribution | Promotion to bye-fellow |
| Impact | Promotion to bye-fellow |
| Start Year | 2024 |
| Description | Dr Maura Malpetti (Rowe Group) Collaboration with McGill University |
| Organisation | McGill University |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | • Collaboration with Dr. Matthias Brendel at the Ludwig Maximilian University of Munich (Germany) and Prof. Pedro Rosa-Neto at the McGill University (Canada) on the project "TSPO PET in tauopathies" |
| Collaborator Contribution | • Collaboration with Dr. Matthias Brendel at the Ludwig Maximilian University of Munich (Germany) and Prof. Pedro Rosa-Neto at the McGill University (Canada) on the project "TSPO PET in tauopathies" |
| Impact | • Collaboration with Dr. Matthias Brendel at the Ludwig Maximilian University of Munich (Germany) and Prof. Pedro Rosa-Neto at the McGill University (Canada) on the project "TSPO PET in tauopathies" |
| Start Year | 2025 |
| Description | Dr Maura Malpetti (Rowe Group) Collaboration with Prof Gabor Kovacs at the University of Toronto |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | • Collaboration with Prof Gabor Kovacs at the University of Toronto (Canada): "RT-Quick in PSP" |
| Collaborator Contribution | • Collaboration with Prof Gabor Kovacs at the University of Toronto (Canada): "RT-Quick in PSP" |
| Impact | • Collaboration with Prof Gabor Kovacs at the University of Toronto (Canada): "RT-Quick in PSP" |
| Start Year | 2025 |
| Description | Dr Maura Malpetti (Rowe Group) Collaboration with Prof. Gil Rabinovici at the University of California San Francisco |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | • Research visit (February-April 2025) and Collaboration with Prof Gil Rabinovici at the University of California San Francisco on multiple studies |
| Collaborator Contribution | • Research visit (February-April 2025) and Collaboration with Prof Gil Rabinovici at the University of California San Francisco on multiple studies |
| Impact | • Research visit (February-April 2025) and Collaboration with Prof Gil Rabinovici at the University of California San Francisco on multiple studies |
| Start Year | 2025 |
| Description | Dr Maura Malpetti (Rowe Group) Collaboration with University of Cardiff |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | • Collaboration with Prof Paul Morgan and Dr Wiola Zelek at the University of Cardiff (UK): "Complement assays in neurodegenerative diseases" |
| Collaborator Contribution | • Collaboration with Prof Paul Morgan and Dr Wiola Zelek at the University of Cardiff (UK): "Complement assays in neurodegenerative diseases" |
| Impact | • Collaboration with Prof Paul Morgan and Dr Wiola Zelek at the University of Cardiff (UK): "Complement assays in neurodegenerative diseases" |
| Start Year | 2025 |
| Description | Dr Maura Malpetti (Rowe Group) Collaboration with University of Gothenburg |
| Organisation | University of Gothenburg |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | • Collaboration with Dr Rik Ossenkoppele, VU University Medical Center Amsterdam & Lund University on projects with Tau PET in AD and non-AD |
| Collaborator Contribution | • Collaboration with Dr Rik Ossenkoppele, VU University Medical Center Amsterdam & Lund University on projects with Tau PET in AD and non-AD |
| Impact | • Collaboration with Dr Rik Ossenkoppele, VU University Medical Center Amsterdam & Lund University on projects with Tau PET in AD and non-AD |
| Start Year | 2024 |
| Description | Dr Maura Malpetti (Rowe Group) Collaboration with VU University Medical Center Amsterdam & Lund University |
| Organisation | VU University Medical Center |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | • Collaboration with Dr Rik Ossenkoppele, VU University Medical Center Amsterdam & Lund University on projects with Tau PET in AD and non-AD |
| Collaborator Contribution | • Collaboration with Dr Rik Ossenkoppele, VU University Medical Center Amsterdam & Lund University on projects with Tau PET in AD and non-AD |
| Impact | • Collaboration with Dr Rik Ossenkoppele, VU University Medical Center Amsterdam & Lund University on projects with Tau PET in AD and non-AD |
| Start Year | 2025 |
| Description | Dr Maura Malpetti (Rowe Group) Collaboration with • Collaboration with Ludwig Maximilian University of Munich |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | • Collaboration with Prof Matthias Brendel, Prof Gunther Hoglinger, and Dr Nicolai Franzmeier at the Ludwig Maximilian University of Munich (Germany) on multiple studies |
| Collaborator Contribution | • Collaboration with Prof Matthias Brendel, Prof Gunther Hoglinger, and Dr Nicolai Franzmeier at the Ludwig Maximilian University of Munich (Germany) on multiple studies |
| Impact | • Collaboration with Prof Matthias Brendel, Prof Gunther Hoglinger, and Dr Nicolai Franzmeier at the Ludwig Maximilian University of Munich (Germany) on multiple studies |
| Start Year | 2025 |
| Description | Future collaboration discussion with Dorothy Hammerer (UCL) on atomoxetine studies within Alzheimeri's Disease |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | As above. Attendees from University of Cambridge: Prof Rowe, Dr Rong Ye, Dr Luca Passamonti, Dr Cat Rua and from UCL Dr Dorothy Hammerer. |
| Collaborator Contribution | To be discerned. |
| Impact | To be discerned. |
| Start Year | 2020 |
| Description | Genetics of neurodegeneration collaboration with Van Andel University |
| Organisation | Van Andel Institute |
| Country | United States |
| Sector | Private |
| PI Contribution | several hundred dementia case samples from longitudinal series of deep phenotyping |
| Collaborator Contribution | genotyping and genotype interpetation |
| Impact | pending |
| Start Year | 2019 |
| Description | LC collaboration |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have engaged with two UCL groups who have a shared interest in noradrenergic systems, and imaging f the locus ceruleus in particular, with data sharing and plans for joint papers. |
| Collaborator Contribution | New sequences and clinical applications of the MR technology |
| Impact | A joint position paper Data sharing |
| Start Year | 2018 |
| Description | Movement Disorder Society PSP study group |
| Organisation | International Parkinson and Movement Disorder Society (MDS) |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | 22 international sites are drawn together under this consortium, to advance PSP and CBS research and care, including biomarkers and clinical trials |
| Collaborator Contribution | Expertise, trials design, new data sharing agreement |
| Impact | Satellite meetings annually Pathology samples sharing Imaging data sharing Joint response to FDA on trial design issues |
| Start Year | 2018 |
| Description | NIHR BRC |
| Organisation | National Institute for Health and Care Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Biomarker development, including cognitive and imaging based deep phenotyping; |
| Collaborator Contribution | Cellular, physiological, radio-chemistry, genetic and pharmaceutical innovations within a pipeline for novel drug discovery; |
| Impact | Adams, N. E., Hughes, L. E., Phillips, H. N., Shaw, A. D., Murley, A. G., Nesbit, D., Cope, T. E., Bevan-Jones, W. R., Passamonti, L., Rowe, J. B. (2020). GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco magnetoencephalography, Journal of Neuroscience, https://doi.org/10.1523/JNEUROSCI.1689-19.2019. Lewis-Smith, D. J., Wolpe, N., Ghosh, B. C. P., Rowe, J. B. (2020). Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia, Journal of Neurology, https://doi.org/10.1007/s00415-019-09672-8. Jabbari, E., Chelban, V., Holland, N., Jones, P. S., Lamb, R., Rawlinson, C., Guo, T., Costantini, A. A., Tan, M. M. X., Heslegrave, A. J., Roncaroli, F., Klein, j. C., Ansorge, O., Allinson, K. S. J., Jaunmuktane, Z., Holton, J. L., Revesz, T., Warner, T. T., Lees, A. J., Zetterberg, H., Russell, L. L., Bocchetta, M., Rohrer, J. D., Williams, N. M., Grosset, D. G., Burn, D. J., Pavese, N., Gerhard, A., Kobylecki, C., Leigh, P. G., Church, A., Hu, M. T. M., Woodside, J., Houlden, H., Rowe, J. B., Morris, H. R. (2020). Diagnosis across the spectrum of progressive supranuclear palsy and corticobasal syndrome, JAMA Neurology, doi:10.1001/jamaneurol.2019.4347. van der Ende, E. L,, Meeter, L. H., Poos, J. M., Panman, J. L., Jiskoot, L. C., Dopper, E. G. P., Papma, J. M., de Jong, F. J., Verberk, I., Teunissen, C. E., Rizopoulos, D., Heller, C., Convery, R. S., Moore, K. M., Bocchetta, M., Neason, M., Cash, D. M., Borroni, B., Galimberti, D., Sanchez-Valle, R., Laforce, Jr R., Moreno, F., Synofzik, M., Graff, C., Masellis, M., Tartaglia, M. C., Rowe, J. B., Vandenberghe, R., Finger, E., Tagliavini, F., de Mendonça, A., Santana, I., Butler, C., Ducharme, S., Gerhard, A., Danek, A., Levin, J., Otto, M., Frisoni, G. B., Cappa, S., Pijnenburg, Y. A. L., on behalf of the GENetic Frontotemporal Dementia Initiative (GENFI), Rohrer, J. D., van Swieten, J. C. (2019). Longitudinal serum neurofilament light chain in genetic frontotemporal dementia: a multicentre cohort study. Lancet Neurology, 18: 1103-1111, https://doi.org/10.1016/S1474-4422(19)30354-0. Shafto, M. A., Henson, R. N., Matthews, F. E., Taylor, J. R., Emery, T., Erzinclioglu, S., Hanley, C., Rowe, J. B., Cusack, R., Calder, A. J., Marslen-Wilson, W. D., Duncan, J., Dalgleish, T., Brayne, C., Cam-CAN, Tyler, L. K. (2019). Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project, Journal of Aging and Health, doi: 10.1177/0898264319878095 [ahead of print], PMID: 31592706 Lansdall, C. J., Coyle-Gilchrist, I. T. S., Vázquez Rodríguez, P., Wilcox, A., Wehmann, E., Robbins, T. W., Rowe, J. B. (2019). Prognostic importance of apathy in syndromes associated with Frontotemporal lobar Degeneration, Neurology, 92(14):e1547-e1557. doi: 10.1212/WNL.0000000000007249, PMID: 30842292, PMC: 6448451. Borchert, B. J., Rittman, T., Rae, C. L., Passamonti, L., Jones, P. S., Vatansever, D., Vazquez-Rodriguez, P., Ye, Z., Nombela, C., Hughes, L. E., Robbins, T. W., Rowe, J. B. (2019). Atomoxetine and citalopram alter brain network organization in Parkinson's disease, Brain Communications, 1:1 fcz013, https://doi.org/10.1093/braincomms/fcz013. PMID: [pending], PMC: [pending]. Nicastro, N., Surendranathan, A., Mak, E., Rowe, J. B.*, O'Brien, J. T.* (2019). 11C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia, Annals of Clinical and Translational Neurology, doi: 10.1002/acn3.50877, PMID: 31507085, PMC: [pending]. Low, A., Mak, E., Malpetti, M., Chouliaras, L., Nicastro, N., Su, L., Holland, N., Rittman, T., Vázquez Rodríguez, P., Passamonti, L., Bevan-Jones, W. R., Jones, P. S., Rowe, J. B.*, O'Brien, J. T.* (2019). Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features, Alzheimer's & Dementia: Diagnosis, Assessment, & Disease Monitoring, 11: 690-699, DOI: https://doi.org/10.1016/j.dadm.2019.08.001, PMID: 31667328, PMC: 6811895. Tavares, T. P., Mitchell, D. G. V., Coleman, K., Shoesmith, C., Bartha, R., Cash, D. M., Moore, K. M., van Swieten, J. C., Borroni, B., Galimberti, D., Tartaglia, M. C., Rowe, J. B., Graff, C., Tagliavini, F., Frisoni, G., Cappa, S., Laforce, R. Jr, de Mendonça, A., Sorbi, S., Wallstrom, G., Masellis, M., Rohrer, J. D., Finger, E. C., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Ventricular volume expansion in presymptomatic genetic frontotemporal dementia, Neurology, doi: 10.1212/WNL.0000000000008386, PMID: 31578297, PMC: [pending]. Passamonti, L., Tsvetanov, K. A., Jones, P. S., Bevan-Jones, W. R., Arnold, R., Borchert, R. J., Mak, E., Su, L., O'Brien, J. T.*, Rowe, J. B.* (2019). Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance, Journal of Neuroscience, doi: 10.1523/JNEUROSCI.2574-18.2019. PMID: 31320450, PMC: 6733539. Jabbari, E., Woodside, J., Guo, T., Magdalinou, N. K., Chelban, V., Athauda, D., Lees, A. J., Foltynie, T., Houlden, H., Church, A., Hu, M. T., Rowe, J. B., Zetterberg, H., Morris, H. R. (2019). Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes, Journal of Neurology, Neurosurgery and Psychiatry, 90(7):768-773. doi: 10.1136/jnnp-2018-320151. PMID: 30867224, PMC: 6585258. Hughes, L. E., Henson, R. N., Pereda, E., Bruña, R., López-Sanz, D., Quinn, A. J., Woolrich, M. W., Nobre, A. C., Rowe, J. B., Maestú, F., BioFIND Working Group (2019). Biomagnetic biomarkers for dementia: A pilot multicentre study with a recommended methodological framework for magnetoencephalography, Alzheimers & Dementia (Amsterdam, Netherlands), 11:450-462. doi: 10.1016/j.dadm.2019.04.009. PMID: 31431918, PMC: 6579903. Shaw, A. D., Hughes, L. E., Moran, R., Coyle-Gilchrist, I., Rittman, T., Rowe, J. B. (2019). In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies. Cerebral Cortex. 2019. doi: 10.1093/cercor/bhz024. PMID: 31216360. van Eimeren, T., Antonini, A., Berg, D., Bohnen, N., Ceravolo, R., Drzezga, A., Höglinger, G. U., Higuchi, M., Lehericy, S., Lewis, S., Monchi, O., Nestor, P., Ondrus, M., Pavese, N., Peralta, M.C., Piccini, P., Pineda-Pardo, J. Á., Rektorová, I., Rodríguez-Oroz, M., Rominger, A., Seppi, K., Stoessl, A. J., Tessitore, A., Thobois, S., Kaasinen, V., Wenning, G., Siebner, H. R., Strafella, A. P., Rowe, J. B. (2019). Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System. Alzheimers & Dementia (Amsterdam, Netherlands). 11:301-309. doi: 10.1016/j.dadm.2019.01.011. PMID: 30984816, PMC: 6446052. Rittman, T., Borchert, R., Jones, P. S., van Swieten, J., Borroni, B., Galimberti, D., Masellis, M., Tartaglia, M. C., Graff, C., Tagliavini, F., Frisoni, G. B., Laforce, R. Jr, Finger, E., Mendonça, A., Sorbi, S., Rohrer, J. D., Rowe, J. B., GENetic Frontotemporal Dementia Initiative (GENFI) (2019). Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia, Neurobioly of Aging, 77:169-177. doi: 10.1016/j.neurobiolaging.2018.12.009, PMID: 30831384; PMC: 6491498. Bevan-Jones, W. R., Cope, T. E., Jones, P. S., Passamonti, L., Hong, Y. T., Fryer, T., Arnold, R., Coles, J. P., Aigbirhio, F. I., O'Brien, J. T., Rowe, J. B. (2019). In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier. Annals of Clinical Translational Neurology, 6(2):373-378. doi: 10.1002/acn3.683. PMID: 30847369; PMC: 6389753. |
| Start Year | 2017 |
| Description | Prof. James Rowe - Alector |
| Organisation | Alector |
| Country | United States |
| Sector | Private |
| PI Contribution | Advisory and research. |
| Collaborator Contribution | Advisory and research. |
| Impact | Advisory and research. |
| Start Year | 2024 |
| Description | Prof. James Rowe - Booster |
| Organisation | Boostec |
| Country | France |
| Sector | Private |
| PI Contribution | Advisory and research. |
| Collaborator Contribution | Advisory and research. |
| Impact | Advisory and research. |
| Start Year | 2024 |
| Description | Prof. James Rowe - Clinical Ink |
| Organisation | Irish Critical Care Clinical Trials Network |
| Country | Ireland |
| Sector | Hospitals |
| PI Contribution | Advisory and research. |
| Collaborator Contribution | Advisory and research. |
| Impact | Advisory and research. |
| Start Year | 2024 |
| Description | Prof. James Rowe - Ferrer |
| Organisation | Ferrer Internacional |
| Country | Spain |
| Sector | Private |
| PI Contribution | Advisory and research |
| Collaborator Contribution | Advisory and research |
| Impact | Ongoing |
| Start Year | 2024 |
| Description | Supervisor with Caius Higher Aspiration Scheme - Rebecca Williams (Rowe Group) |
| Organisation | University of Cambridge |
| Department | Gonville and Caius College |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supervisor to 6 students (Year 12) |
| Collaborator Contribution | Aspiration Scheme |
| Impact | Student development. |
| Start Year | 2022 |
| Description | Ultrahigh resolution imaging of neurodegeneration and vascular risk in aging and preclinical and prodromal Alzheimer's Disease |
| Organisation | The Otto-von-Guericke University Magdeburg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | New consortium to faciliate and validate 7T in dementia research, across 15 EU sites. Meets and draft preparation |
| Collaborator Contribution | Led by Prof Duzel, Magdeburg, a consortium building on EUFIND. |
| Impact | None yet. Funding sought |
| Start Year | 2019 |
| Description | Visiting Researcher at University of California San Francisco (US) - Dr Maura Malpetti |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Visiting researcher at University of California San Francisco (US) |
| Collaborator Contribution | Visiting researcher at University of California San Francisco (US) |
| Impact | Visiting researcher at University of California San Francisco (US) |
| Start Year | 2025 |
| Title | 7T altas of Locus Coeruleus |
| Description | Based on findings reported in https://doi.org/10.1016/j.neuroimage.2020.117487, methodology has been licensed to INVICRO (Hammersmith, London) |
| IP Reference | |
| Protection | Trade Mark |
| Year Protection Granted | 2023 |
| Licensed | Yes |
| Impact | Methodology open to sharing with other research groups. Non-exclusive commercial license with INVICRO. |
| Title | Atomoxetine in PSP |
| Description | new drug strategy for impulsivity in PSP to be tested for first time. |
| Type | Therapeutic Intervention - Drug |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2017 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | reduced impulsivity in selected patients |
| Title | Biomarker evaluation of 7T MRI in dementia |
| Description | evaluation of novel 7T MRI for early detection of pathology in AD, and other dementias, building on the JPND consortium "EUFIND" |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2020 |
| Development Status | Under active development/distribution |
| Impact | stronger links to basic cognitive neurosciences of memory systems, and to multi-centre clinical transnational centres across EU |
| Description | 'Sleep, Consciousness and Cognition' Dr Marlou Perquin (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | • Poster presentation at the Cambridge Neuroscience Seminar, Cambridge, CNS2024: 'Sleep, Consciousness and Cognition'. The target audience is local neuroscientists from any discipline as well as those interested specifically in the topic of consciousness. Audience size was ~250 delegates. Perquin, M.N., Daghlian, M., Perry, G., Singh, K., & Bompas, A. (2024). Predicting ongoing fluctuations in behavioural variability and subjective attentional state. Cambridge Neuroscience Seminar, Cambridge. |
| Year(s) Of Engagement Activity | 2024 |
| Description | (Dr Sanne Kaalund) 121st Meeting of the British Neuropathological Society 4-6 March 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Kaalund presented the following talk: Locus coeruleus pathology in progressive supranuclear palsy is associated with disease severity. Day: Friday 6th March 2020 Time: 09:45:00 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bns.org.uk/event/121st-meeting-of-the-bns/ |
| Description | 121st British Neuropathological Society Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The meeting is focused on neuropathology, this year with special focus on neurodegenerative diseases and prion-like properties of mis-folded proteins in dementia. Dr Sanne Kaalund will be giving the talk titled "Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severit." |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.bns.org.uk/event/121st-meeting-of-the-bns/ |
| Description | ARUK Clinical Conference. talk titled "What's new in Frontotemporal Dementia?" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | This conference focussed on the themes of research, innovation, and implementing change in clinical practice. |
| Year(s) Of Engagement Activity | 2021 |
| Description | All About Brians - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Virtual contribution at Storyhouse Theatre Chester, UK. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Alzheimer's Association International Conference - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "From glia to cytokine signatures across the Alzheimer's spectrum (and beyond)" - Alzheimer's Association International Conference (AAIC, Philadelphia, 31/07/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Article & Interview Neurodegenerative Disease and Dementia |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Damage to the brainstem - the brain's 'control centre' - is behind long-lasting physical and psychiatric effects of severe Covid-19 infection, a study suggests. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://cambridgebrc.nihr.ac.uk/tag/neurodegenerative-disease-and-dementia/ |
| Description | Ask a Dr Event - Dr Negin Holland (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited clinician at the PSP Association 'Ask the Dr event' - at least 3 times/year |
| Year(s) Of Engagement Activity | 2023 |
| Description | Astex Pharmaceuticals Seminar Cambridge - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Inflammation biomarkers in FTD and related disorders: from pathological pathways to clinical trials" - Astex Pharmaceuticals Seminar (Cambridge, 30/08/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Atlas-based in vivo Measurement of Human Locus Coeruleus in Neurodegenerative Disorders with 7T MRI (OHBM 2020) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Showcasing the application of the 7T Locus Coeruleus Atlas in neurodegenerative disorders. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.humanbrainmapping.org/i4a/pages/index.cfm?pageid=3958 |
| Description | BBC Persian Interview on Dementia Research January 2024 - Dr Negin Holland & Prof. James B Rowe |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviewed by BBC Persian about Dementia research on 25th January 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | BarcelonaBeta - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Brain inflammation in dementia: what can we learn from PET imaging and blood markers?" - BarcelonaBeta (Barcelona, 02/04/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Bevan-Jones, W. R. Current practice and future directions. PSP Association Public Meeting (2017) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | Bevan-Jones, W. R. (2017). Current practice and future directions. PSP Association Public Meeting, Crewe, UK. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The Big Biology Day at Hills Road Sixth Form College, Cambridge, is a science festival celebrating the life sciences through hands-on activities, crafts, and interactive displays. As a volunteer at the Alzheimer's Research UK stand, I helped educate children about brain health and dementia, contributing to the event's mission to engage people of all ages with science. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Big Biology Day - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Live at Hills Road Sixth Form, collaboration with ARUK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Brain Bank Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Regional Brain Bank meeting, chair |
| Year(s) Of Engagement Activity | 2023 |
| Description | Brain Conference, talk given on "Apathy and Impulsivity" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation during cognition and dementia theme of Brain conference 2021. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Brain Imaging A Short Taster - Psychi Summer Camp (Dr Laura Hughes - Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Brain imaging - a short taster". Psychi Summer Camp, online, August 2024 Audience: Undergraduate Students |
| Year(s) Of Engagement Activity | 2024 |
| Description | Brain Models & Pipecleaner Neurons (Rebecca Williams - Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Collaboration with CHaOS - live at school in St. Neots, UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | British Neuropathological Society meeting, Cirencester, UK 3-5 July 2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Attended by Dr Luca Passamonti and Dr Sanne Kaalund to strenghten their network in neuropathology research. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bns.org.uk/wp-content/uploads/2018/12/Programme_BNSSummerSchool2019.pdf |
| Description | British Neuropsychiatry Association guest lecture - Apathy and Impulsivity in FTLD - not all dopamine, degeneration and death - Oxford 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | TBC |
| Year(s) Of Engagement Activity | 2019 |
| Description | CBU Science Night - MEG Demo (Dr Marlou Perquin - Rowe Group) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | • MEG demonstration at the CBU science night (public engagement). The target audience is laypeople with an interest in cognitive neuroscience research. Audience size for the MEG demonstrations was about 50 people in total. |
| Year(s) Of Engagement Activity | 2024 |
| Description | CCPP patient liaison |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | A patient liaison group, to advise and feedback on experience of research participation, and future studies' documentation. |
| Year(s) Of Engagement Activity | 2018,2019 |
| Description | CHaOS Summer Roadshow (Rebecca Williams - Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Live at Poacher Scout's Jamboree (over 6000 in attendance) |
| Year(s) Of Engagement Activity | 2022 |
| Description | CUH Memory Clinic Annual Study and Review Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | CUH Memory clinic annual study and review day |
| Year(s) Of Engagement Activity | 2023 |
| Description | Care pathways for CBD |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Working group to develop new care pathways and national standards of care for CBD and related disorders |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cerevance Seminar Cambridge (Dr Maura Malpetti - Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Inflammation biomarkers in FTD and related disorders: from pathological pathways to clinical trials" - Cerevance Seminar (Cambridge, 29/01/2025) |
| Year(s) Of Engagement Activity | 2025 |
| Description | Chair at Tau 2024 International Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Tau2024 Global Conference | March 25 - 26, 2024 | Washington, D.C., USA and Online 1 Leading tau experts from around the world representing academia, industry, government and the philanthropic sector will come together to collaborate and discuss key issues impacting the tau research community. Scientific Program Committee James Rowe, chair |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://istaart.alz.org/events/item/23/127 |
| Description | Channel 4 - cognitive enhancement |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviews and experiment conducted under on camera, into cognitive enhancement |
| Year(s) Of Engagement Activity | 2018 |
| Description | Collaboration with artist for Creative Reactions - Dr Marlou Perquin (Rowe Group) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | • Collaboration with artist for Creative Reactions, which is a standalone part of Pints of Science. Part of the scientific speakers are paired up with a local artist who makes an art work inspired by the researcher's topic. Emily Jolley from Emily Jolley Fine Art created two paintings based on the topic of intra-individual variability and dementia. Over and over, Emulsion paint and graphite on board Until it's over, Emulsion paint and graphite on board |
| Year(s) Of Engagement Activity | 2024 |
| Description | Coordinator FTDUK Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | FTDUK - coordinator and talk London |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ftduk.org/previous-programmes/#1684055574796-923f2281-2b7e |
| Description | Coping with Exam Stress - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | In collaboration with Study Together |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dementia Champions link Day - Dr Anna Dreyer (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Staff from a variety of in-patient clinical areas attended Dementia Champion link day at Hinchingbrooke Hospital (25 March 2024) and Peterborough City Hospital (24 June 2024) where I did presentations on dementia research |
| Year(s) Of Engagement Activity | 2024 |
| Description | Dementia Chatathon - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Collaboration with Dementia Researcher, watched via Youtube, Twiter & Twitch |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dementia Researcher Podcasts and Fundraising events - Dr M Malpetti |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | https://www.dementiaresearcher.nihr.ac.uk/tag/dr-maura-malpetti/ |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dementiaresearcher.nihr.ac.uk/tag/dr-maura-malpetti/ |
| Description | Diagnosis and management of PSP |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | SW Movement disroders group, event at Royal College of Physicians |
| Year(s) Of Engagement Activity | 2018 |
| Description | Dr Amirhossein Jafarian - Media interview (Rowe Group) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | See interview. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.dementiasplatform.uk/about-us/teams-and-people/amirhossein-jafarian-1 |
| Description | Dr Anna J Dreyer (Rowe Group) Invited Speaker Tau 2025 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dissemination of the findings of this project at Tau 2025 in London, UK |
| Year(s) Of Engagement Activity | 2025 |
| Description | Dr D Street Poster Presentation @ Alzheimer's Association International Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prodromal markers of neurodegenerative disease - insights from UK Biobank. Alzheimer's Association International Conference Annual Meeting 2021 poster presentation. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://alz.confex.com/alz/2021/meetingapp.cgi/Paper/49865 |
| Description | Dr D Street Poster Presentation @ American Association of Neurology on Prodromal Parkinson's disease - insights from UK Biobank |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prodromal Parkinson's disease - insights from UK Biobank. American Academy of Neurology Annual Meeting 2021 poster presentation. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://index.mirasmart.com/AAN2021/PDFfiles/AAN2021-002229.html |
| Description | Dr D Street: Thesis in 3 Minutes Talk at UK Biobank Scientific Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Thesis in three minutes. Three-minute talk as part of the UK Biobank Scientific Conference 2021. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.youtube.com/watch?v=_zTsJIbgWIk |
| Description | Dr Frank Hezemans - Festival of Neuroscience 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presenting recent results regarding the role of the locus coeruleus in apathy in Parkinsons disease. The purpose is to generate discussion and raise awareness of the role of this brain region and in regulating cognitive deficits associated in Parkinsons disease. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://meetings.bna.org.uk/bna2021/ |
| Description | Dr Frank Hezemans - Neuroscience Network Symposium, Cambridge (27th Jul '19) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Approx 100 researchers attended (viewed poster presentation) on recent results from Parkinsons disease study, focusing on mechanisms of sensory/motor integration and potential benefit of treatment by atomoxetine. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.neuroscience.cam.ac.uk/events/ABC2019/pages/about-abc.html |
| Description | Dr Frank Hezemans - Poster presentation at International Behavioral Neuroscience Society 2020 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Approx 100 researchers attended (viewed poster presentation) on recent results from Parkinsons disease study, focusing on mechanisms of sensory/motor integration and potential benefit of treatment by atomoxetine. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.ibnsconnect.org/ibns-2020-annual-meeting |
| Description | Dr Frank Hezemans - Science Night 2021 prerecorded talk aimed at the general public about Parkinson's disease and noradrenaline |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Public event discussing various research studies bering carried out at MRC Cognition and Brain Sciences unit (University of Cambridge). Dr Hezemens focuses particularly on discussing Parkinson's disease and the effects of noradrenaline on the brain. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.mrc-cbu.cam.ac.uk/blog/2020/01/mrc-cbu-science-night-cambridge-science-festival-2020/ |
| Description | Dr M Malpetti Speaker at Cambridge Alumni Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | • Speaker at Cambridge Alumni Festival public talk: "Brain inflammation in the race against dementia" (~150 attendees, Cambridge 28/09/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Dr M Malpetti Speaker at TEDxMantova Talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mantua |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.ted.com/tedx/events/57098 |
| Description | Dr M Malpetti Speaker at the ARUK Public webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr M Malpetti Speaker at the ARUK Public webinar |
| Year(s) Of Engagement Activity | 2025 |
| Description | Dr M Malpetti • Speaker at the PSPA research day |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | • Speaker at the PSPA research day: "Brain scans and blood tests to track inflammation (~70 attendees, virtual, 23/05/2024) |
| Year(s) Of Engagement Activity | 2025 |
| Description | Dr M Malpetti • Speaker at the Race Against Dementia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | • Speaker at the Race Against Dementia summit "Where dementia research meets F1 mentality" (~100 attendees, 11/09/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Dr Maura Malpetti (Rowe Group): Oral Presentation at DPUK Translation 2023 Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation on "Post mortem validation of in vivo PET imaging: test case of inflammation in progressive supranuclear palsy" |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.dementiasplatform.uk/research-hub/translation-2023/early-career-researchers-workshop-and... |
| Description | Dr Maura Malpetti PSPA (Progressive Supranuclear Palsy Association) research committee member |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Committee member |
| Year(s) Of Engagement Activity | 2024 |
| Description | Dr Maura Malpetti Tau2025 Conference Organising committee |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Organizer |
| Year(s) Of Engagement Activity | 2024 |
| Description | Dr Rong Ye talk at Cambridge Centre for Parkinson's Plus (4th May 2020) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented research results on the application of 7T sequence and Atlas in the Parkinsonian diseases. |
| Year(s) Of Engagement Activity | 2020 |
| Description | ECR Talk Translation 2024 DPUK (Dr Amirhossein Jafarian - Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Translation 2024 DPUK 2024 (ECR talk and Poster presentation) |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.youtube.com/watch?v=J8cTqeUoiPw |
| Description | Effective Note Taking Strategies: Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Collaboration with Study Together |
| Year(s) Of Engagement Activity | 2022 |
| Description | EuroWeekly News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A trial hailed as the "holy grail" by experts, conducted by the NHS, is in its first stages this week, with 3,100 participants worried they are showing signs of possible dementia, such as memory loss, to have their blood tested and get a speedy diagnosis. |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://euroweeklynews.com/2025/01/29/holy-grail-revolutionary-new-blood-test-to-diagnose-dementia-u... |
| Description | European Meeting on Imaging of Neurodegenerative Diseases (EU-MIND) - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "PET imaging of synaptic health across neurodegenerative diseases" - European Meeting on Imaging of Neurodegenerative Diseases (EU-MIND, Caen, 26/09/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Experimental Medicine in FTD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk ISFTD meeting Amsterdam n=700 "Experimental medicine in FTD" |
| Year(s) Of Engagement Activity | 2024 |
| Description | FTD Holloway Summit (Miama, USA) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | State of science and clinical epidemiology of FTD. |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.theaftd.org/fr/holloway-summit-2025/ |
| Description | FTD UK Conference, Cambridge UK 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A UK wide cross sector meeting on advances in FTD, from basic science to new theapeutics |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.ftduk.org/ |
| Description | Filmed Charity Broadcast for PSP Association |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | PSPA broadcast. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Greatest Hits Oxfordshire - Hello Rayo! |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Oxford university in trials for blood tests to diagnose dementia A multi-million pound programme is supported by the Alzheimer's Society |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://hellorayo.co.uk/greatest-hits/oxfordshire/news/oxford-university-in-trials-for-blood-tests-t... |
| Description | How to Tackle an Academic Paper - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | How to Tackle an Academic Paper |
| Year(s) Of Engagement Activity | 2022 |
| Description | How to tackle Academic Teading and Writing - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Summer CAMP collaboration. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Human Amyloid Imaging 2025 - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Novel blood-based proteomic signatures for multiple neurodegenerative diseases" - Human Amyloid Imaging 2025 (Puerto Rico, 17/01/2025) |
| Year(s) Of Engagement Activity | 2025 |
| Description | ISTAART FTD PIA symposium - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Fluid markers of inflammation in FTLD" - ISTAART FTD PIA symposium (Virtual, 24/04/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Inernational symposium on PSP/CBD |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International symposium, including talk and posters from our group, on progress in PSP and CBD reesarch Engagement with Pharma |
| Year(s) Of Engagement Activity | 2018 |
| Description | International Congress of Parkinson's Disease and Movement Disorders - Nice 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Advances in PSP and its overlap with FTD, main meeting and satellite symposia on PSP and Brain Imaging |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.mdscongress.org/Congress-Branded/19FP-_blue_puzzle_online.pdf |
| Description | International Society of Frontotemporal Dementia Conference - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Blood-based inflammation markers predict survival in syndromes associated with FTLD" - International Society of Frontotemporal Dementia Conference (Amsterdam, 22/09/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Interventional Studies - Cinical Research Training Day (Dr Laura Hughes - Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interventional Studies" Clinical training day at HSB, in person. August 2024 Audience: New staff and students at HSB. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Investigating Blood-Based Biomarkers With Dr. Maura Malpetti |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | DESCRIPTION Clinical trials are urgently needed for PSP and CBD. Dr. Maura Malpetti and her team at the University of Cambridge have identified chronic brain inflammation as a key contributor to disease progression, and are developing a blood test for inflammation that will help track the effectiveness of clinical trials and treatments, thus accelerating the development of more clinical trials. |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.psp.org/podcast/episode/maura-pod |
| Description | Invited Lecturer at Statistical Parametric Mapping Course, London - Dr A Jafarian (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dynamic causal modelling |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited delegate World Dementia Council Summit |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Expert panel on current state of dementia research and impact, globally. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited speakers (Dr Rong Ye and Dr Cat Rua) to present 7T Locus Coerelus at the Danish Research Centre for Magnetic Resonance (Oct 2019) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Rong Ye and Dr Cat Rua were invited to discuss the 7T research conducted at University of Cambridge. Future actions for collaborations were also discussed. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Lansdall, C. (May 2018). Organising Committee for Pint of Science, Annual Science Festival, Castle Bar, Cambridge, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Discuss science with general public. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Lecture on "Introduction to Neuroimaging" at MRC CBU Course - Dr M Malpetti |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Lecture on the "Introduction to Neuroimaging" course at the MRC Cognition and Brain Science Unit, University of Cambridge (Cambridge, 06/02/2023): "PET imaging" |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://imaging.mrc-cbu.cam.ac.uk/methods/IntroductionNeuroimagingLectures |
| Description | Let's Talk Science - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Skyped in to Birmingham, USA |
| Year(s) Of Engagement Activity | 2022 |
| Description | Let's Talk Science! Skype a Scientist, Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Engagement via Skype a Scientist to Missouri, USA. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Locus Coeruleus Imaging Meeting Magdeburg 2019 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This workshop was attended by Dr Luca Passamonti, Dr Sanne Kaalund, Dr Rong Ye and Dr Catarina Rua. The team were showcasing research in LC and the use of 7T. At this years LC meeting, we aim to focus on the following questions: 1. How can we improve structural / functional / PET LC imaging? 2. What is the role and fate of the LC in neurodegenerative and clinical conditions? What renders the LC particularly vulnerable? 3. What have we learned (also from animal research) on the LCs role in cognition and behavior in the last years? 4. What are the most promising interventions targeting the LC / NA system? We will post a detailed program on the website and send it via email to all registered users at a later date. Please see information on our previous meeting held last February and the resultant consensus paper summarizing how LC imaging can be used for clinical research in neurodegenerative diseases. New for this years meeting are 1-2 methods workshops for those interested: A two day hackathon (Saturday 14th and Sunday 15th) where MR physicists will do some hands-on tests to explore new imaging approaches (this will be mostly relevant for MR physicists doing LC imaging) If there is enough interest, an extra session on LC methods in animal research (electrophysiology, high-field imaging, optogenetics, ...) which will take place on Saturday 14th. Please let us know if you would like to join either of these! |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.iknd.ovgu.de/LC+Meeting+2019.html |
| Description | Lundbeck Foundation Neuroscience Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk - Lundbeck Foundation Neuroscience Network Copenhagen "Synaptic Health" |
| Year(s) Of Engagement Activity | 2024 |
| Description | MEG as a Platform for Clinical Trials - MEGIN Pharmaco Symposium (Dr Laura Hughes - Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "MEG as a platform for clinical trials. From understanding disease to supporting experimental medicine" MEGIN Pharmaco Symposium, Geneva, 8th April 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | MEG as a platform for clinical trials - Dr Laura Hughes (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "MEG as a platform for clinical trials. From understanding disease to supporting experimental medicine" Joint Spring symposium Clinical Neurophysiology & Belgian Neurological Society, Brussels, 16th March 2024 o Audience: ~150 people, audience is academic staff and student members of the Belgium societies. |
| Year(s) Of Engagement Activity | 2024 |
| Description | MEGIN - MEG in Pharmaco Meeting, Geneva - Prof James B Rowe |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | MEGIN - MEG in pharmaco meeting, Geneva, 8th April 2024 "MEG biomarkers for Alzheimer's disease, mechanisms and progression" Symposium with academic and industry partners N~100 |
| Year(s) Of Engagement Activity | 2024 |
| Description | MSN News |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Simple dementia-detecting blood test begins NHS trial |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.msn.com/en-gb/health/other/simple-dementia-detecting-blood-test-begins-nhs-trial/ar-AA1y... |
| Description | Magnetoencephalography versus blood-based biomarkers of Alzheimer's Disease (Dr Marlou Perquin - Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation plus 3-minute oral presentation at MEG UK, Birmingham. The target audience is MEG researchers in the UK. Audience size was ~200 delegates. Perquin, M.N., Lanskey, J.H., Karadag, M., Kocagoncu, E., Quinn, A.J., Pitt, J., van Es, M., Alcock, C., Shen, C., Krugliak, A., Thayanandan, T., Fye, H., Lowe, S., Perkinton, M., Timmers, M., Raymont, V., Singh, K.D., Woolrich, M., Nobre, A.C., Rowe, J.B., the NTAD group. Magnetoencephalography versus blood-based biomarkers of Alzheimer's Disease. MEG UK, Birmingham. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Media Coverage - The Mirror (Prof James B Rowe) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Media interview |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.mirror.co.uk/news/health/i-think-ive-alzheimers-havent-34573468 |
| Description | Media Coverage - The Sun (Prof James B Rowe) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | GAME CHANGER Simple blood test that could detect dementia 'YEARS before symptoms begin' starts 'exciting' trial in NHS clinics |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.thesun.co.uk/health/33070031/blood-test-dementia-symptoms-nhs-clinics-cheap/ |
| Description | Meeting and Workshop Innsbruck |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | LC Meeting |
| Year(s) Of Engagement Activity | 2024 |
| Description | Milton Keynes FM |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Simple blood test for dementia. |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.mkfm.com/news/technology/simple-blood-test-that-could-detect-dementia-at-early-stage-beg... |
| Description | Mini Linguistic State Examination (MLSE) Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presentation at Mini Linguistic State Examination (MLSE) workshop |
| Year(s) Of Engagement Activity | 2023 |
| Description | Mirror Article on Corticobasal Degeneration feat. Prof James B Rowe |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Retired teacher who walks to slow down her dementia eyes trek round coast of Wales.. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.mirror.co.uk/news/health/retired-teacher-who-walks-slow-29620344 |
| Description | My Memory Clinic and Me |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presented at an event titled My Memory Clinic and Me as part of the Cambridge Festival in March 2021. The Cambridge Memory Clinic provides assessment and management for a wide range of memory and cognitive disorders, for example, due to neurodegeneration (Alzheimer's disease, Mild Cognitive Impairment, Frontotemporal dementia, Dementia with Lewy Bodies) and more. A discussion was help about memory clinics in the context of dementia. How they can help, and what to expect - including their role in leading research that matters to patient care. Short presentations followed by a live Q&A session with consultant neurologists. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://ftd.neurology.cam.ac.uk/events/201cme-and-my-memory-clinic201d |
| Description | NULISA Multi-plex Panels in Dementia - UKDRI Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "NULISA multi-plex panels in dementia" - UKDRI Alamar Oxford Seminar (Oxford, 05/02/2025) |
| Year(s) Of Engagement Activity | 2025 |
| Description | National Advertising Campaign with Alzheimer's Research UK |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | National advertising campaign |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Neuro2024 (PSP/CBS symposium) - Dr Negin Holland (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral Presentation: Neuro2024 (PSP/CBS symposium) - October 2023; attendees over 400 Title: Title: Differential patterns of in vivo synaptic loss in relation to tau accumulation and grey matter atrophy, in amyloid negative vs. positive corticobasal syndrome. Poster Presentation Award received. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Neuro2024 CurePSP symposium - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Beyond tau: PET imaging of inflammation and synapses in PSP/CBD" - Neuro2024 CurePSP symposium (Toronto, 24/10/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Neuroinflammation in Neurodegeneration Symposium CAMBRIDGE - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Inflammation fingerprints in dementia: from brain imaging to blood tests" - Neuroinflammation in Neurodegeneration Symposium (Cambridge, 17/04/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Neuroscience Academy Denmark Annual Symposium - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Present and future of PET imaging in frontotemporal dementia and related disorders" - Neuroscience Academy Denmark Annual Symposium (Copenhagen, 29/10/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | News Coverage - This is the Coast Radio |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This is the coast |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.thisisthecoast.co.uk/news/video/simple-blood-test-that-could-detect-dementia-at-early-st... |
| Description | OLS/UKRI cross sector specialist workshop/committee for new national dementia initiative strategy for 2022 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Meeting with No.10 officials on UK Dementia landscape. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | Oral Presentation - Dr K Stockton "Metabolomic effects of sporadic, genetic and pre-symptomatic frontotemporal dementia" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Metabolomic effects of sporadic, genetic and pre-symptomatic frontotemporal dementia. GENFI winter meeting International meeting of research study |
| Year(s) Of Engagement Activity | 2022 |
| Description | Oral Presentation @ ADPD Barcelona 20222- Dr M Malpetti |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | "In vivo PET imaging of inflammation as a prognostic tool in frontotemporal dementia" - ADPD conference (Barcelona, 03/2022) |
| Year(s) Of Engagement Activity | 2022 |
| Description | Oral Presentation Dr D Street at Midlands Neurological Society Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation Non-motor markers predict survival in PSP |
| Year(s) Of Engagement Activity | 2022 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Serum cytokines across dementias: fingerprinting inflammation" - Alzheimer's & Parkinson's Diseases Conference (Gothenburg, 03/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation Dr M Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Peripheral and central markers of inflammation in frontotemporal dementia and related conditions" - Frontotemporal Dementia UK meeting (London, UK, 12/05/2023) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation: Caius Higher Aspiration Scheme - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Caius Higher Aspiration Scheme |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral Presentation: International Society for FTD Dr Negin Holland |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Title: 'Synaptic loss over time is related to worsening symptoms, in people with progressive supranuclear palsy and corticobasal syndrome.' |
| Year(s) Of Engagement Activity | 2022 |
| Description | Oxford Autumn School of Neuroscience - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | • "Inflammation in neurodegeneration: a key player in movement disorders and dementia" -Oxford Autumn School of Neuroscience (Oxford, 08/10/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | PPE - Cambridge university Hospitals Trust members |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | An evening event for the members of the Trust (patients, and local public) to discuss advances in dementia research and care, including the insights from new technologies |
| Year(s) Of Engagement Activity | 2019 |
| Description | PPIE Dementia Group Event at Peckover House, Wisbech (Rowe Group) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Peckover House, Wisbech Lucy Bowns, Dr Maura Malpetti, Rebecca Williams Observations/thoughts/comments • Peckover House has been given funding to provide this dementia group. Currently it is the only National Trust property to offer this. It is hoped that it might expand to another five sites, pending ongoing funding. |
| Year(s) Of Engagement Activity | 2023 |
| Description | PSP Association "Ask the Doctor" with Negin Holland |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | 'Ask the Dr' event for newly diagnosed patients with PSP and CBD. In this 2 hour long session, Dr Holland spoke with newly diagnosed patients and their carers about what PSP/CBD is, current treatments, and management. A question-and-answer session was also held for this group. |
| Year(s) Of Engagement Activity | 2022 |
| Description | PSP Association's Carers' symposium at Windsor - Dr Negin Holland (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research talk given to the PSP Association's Carers' symposium at Windsor- July 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | PSP Matters |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Extended interview on PSP research, researchers, motivation and progress. How donations lead to real research progress, and added value |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://pspassociation.org.uk/information-and-support/just-been-diagnosed/psp-matters/ |
| Description | PSP carers meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Special meeting to initiate a PSP support network locally, and engage families with PSP mattes, clinical and research, and the local team |
| Year(s) Of Engagement Activity | 2018 |
| Description | PSP pathogenesis - Bispebjerg Hospital Copenhagen |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation |
| Year(s) Of Engagement Activity | 2024 |
| Description | PSPA Research Day - Oral Presentation Dr K Stockton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | "Pick's disease and Progressive supranuclear palsy Prevalence and Incidence study (PiPPIN)" 3/2/23 PSPA Research Day Research day for patients and carers, organised by the PSP association |
| Year(s) Of Engagement Activity | 2022 |
| Description | Passamonti, L. (16th May 2018). Halting nerve cell death and improving quality of life in progressive supranuclear palsy. Pint of Science, Annual Science Festival, Castle Bar, Cambridge, UK |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Discuss science with general public. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Pint of Science: Atoms to Galaxies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Events held live in Cambridge UK |
| Year(s) Of Engagement Activity | 2022 |
| Description | Poster Presentation Association of British Neurologists - Dr K Stockton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation titled: Pick's disease and Progressive supranuclear palsy Prevalence and Incidence study (PiPPIN) |
| Year(s) Of Engagement Activity | 2022 |
| Description | Psychiatry Meeting on Drug Treatments in Old Age |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk title "Frontotemporal Dementia" |
| Year(s) Of Engagement Activity | 2023 |
| Description | Public Meeting on Memory - Cambridge Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | In My Memory Clinic and Me (31 March, 4-5.30pm), three internationally renowned experts in the field of dementia research and consultant neurologists at The Cambridge Memory Clinic, Professor James Rowe, Dr Timothy Rittman and Dr Andrew Graham, explain what dementia is and how it affects the brain. They discuss who gets referred to a memory clinic and the path to diagnosis, what happens once a person has been diagnosed, and how attending clinic can help with understanding the diagnosis and obtaining support through, for instance, a specialist dementia nurse. Moreover, they describe the role of the memory clinic in groundbreaking research, how the collaboration between hospitals and academic institutions makes vital research possible, and how this relates to patient care. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.festival.cam.ac.uk/news/press-release-leading-experts-discuss-mental-health-cambridge-fe... |
| Description | Rebecca Williams - A Career in Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Virtual careers session for ~12000 12-18-year-olds in greater New York (TBD March 3rd) |
| Year(s) Of Engagement Activity | 2025 |
| Description | Rebecca Williams - Apathy in Dementia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | University of the Third Age |
| Year(s) Of Engagement Activity | 2025 |
| Description | Rebecca Williams - Gonville & Cauis |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Given multiple times to Y9-11 students as part of an academic taster on their outreach programme (>200 students). |
| Year(s) Of Engagement Activity | 2024 |
| Description | Rebecca Williams - I'm a Scientist (and so are you) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | ~120 primary children (age 7-12) from an area of high depravation. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Rebecca Williams - MEGUK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Living in a World of "Close Enough": Apathy and the Bayesian Brain |
| Year(s) Of Engagement Activity | 2024 |
| Description | Rebecca Williams - Motivation & Dementia |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | CBU Cambridge |
| Year(s) Of Engagement Activity | 2024 |
| Description | Rebecca Williams - Science Communication |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Cambridge Neuroscience |
| Year(s) Of Engagement Activity | 2024 |
| Description | Rebecca Williams - Skype a Scientist Participant |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Lets talk science |
| Year(s) Of Engagement Activity | 2024 |
| Description | Regular Blogger with Dementia Research - Rebecca Williams |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Hello! My name's Rebecca and I'm a second-year PhD student at the University of Cambridge. Though originally from 'up North' in a small town called Leigh, I did my undergraduate and masters at the University of Oxford before defecting/seeing the light (depends who you ask) to Cambridge for my doctorate. I now spend the majority of my days collecting data from our wonderful volunteers, and coding. I maintain that after spending entire days coding analysis pipelines I am very close to actually being able to see the matrix. In my spare time, I am a big fan of crafting in all its forms, and recently got a sewing machine to start designing my own clothes! I also greatly enjoy playing board games, and escape rooms. |
| Year(s) Of Engagement Activity | 2024,2025 |
| URL | https://www.dementiaresearcher.nihr.ac.uk/author/rebecca-williamsmrc-cbu-cam-ac-uk/ |
| Description | Rowe - 11th Cambridge Dementia Course. Oliver Cousins for Advances in Clinical Neuroscience and Rehabilitation (ACNR), (2017). |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Rowe, J. B. (11th April 2017). 11th Cambridge Dementia Course. Oliver Cousins for Advances in Clinical Neuroscience and Rehabilitation (ACNR). |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.acnr.co.uk/2017/04/11th-cambridge-dementia-course/ |
| Description | Rowe - Cambridge Science Festival (2017) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture at Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2017 |
| Description | Rowe - Cambridge Science Festival 2018 - Molecules to Memory - Advances in Dementia Research, hosted by ARUK local network |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | public talk at Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2018 |
| Description | Rowe - FTD Carers' Meeting, Department of Clinical Neurosciences, University of Cambridge, UK (2014) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Rowe, J. B. (24th March 2014). FTD Carers' Meeting, Department of Clinical Neurosciences, University of Cambridge, UK. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Rowe - FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge (2017). |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Rowe, J. B. (13th September 2017). FTD Carers' Meeting. Department of Clinical Neurosciences, University of Cambridge; give feedback to carers and also get feedback from them. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Rowe - FTD-UK Annual Meeting (2017) - Debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A discussion of imaging's contribution to FTD diagnosis, prognosis and stratification |
| Year(s) Of Engagement Activity | 2017 |
| Description | Rowe - Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association) (2017) |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Rowe, J. B. (16th May 2017). Look East. The latest news, sport and weather for the East of England. BBC One. (Feature about PSP Association). |
| Year(s) Of Engagement Activity | 2017 |
| Description | Rowe - PSP Matters (2017) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Research update and progress for PSPA |
| Year(s) Of Engagement Activity | 2016,2017 |
| Description | Rowe Group: Dr D Street - Fresh Thinking at Fitz: The value of Memories |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Virtual fifteen-minute talk followed by panel discussion on current research in memory disorders. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.fitz.cam.ac.uk/news/fresh-thinking-fitz-value-memories |
| Description | Rowe Group: M Naessens Talk @ AAIC Neuroscience Next Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave a lightening round talk titled "7T imaging in behavioural variant frontotemporal dementia and progressive supranuclear palsy." |
| Year(s) Of Engagement Activity | 2021 |
| Description | Rowe Group: M Naessens talk at Cambridge Festival 2021 - My Memory Clinic and Me |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Study participants or study members |
| Results and Impact | Dementia focussed session during Cambridge Festival. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Rowe, J. B. (28th September 2017) Understanding frontotemporal dementia: an interview with Professor James Rowe - Interview for the National Institute for Health Research (NIHR) (2017) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Rowe, J. B. (28th September 2017) Understanding frontotemporal dementia: an interview with Professor James Rowe. Interview for the National Institute for Health Research (NIHR). https://www.nihr.ac.uk/news-and-events/features/behind-the-research/Understanding-frontotemporal-dementia.htm |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.nihr.ac.uk/news-and-events/features/behind-the-research/Understanding-frontotemporal-deme... |
| Description | Rowe/Team - Cambridge Science Festival (2017) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A lecture on the challenge of dementia as part of the Cambridge Science Festival |
| Year(s) Of Engagement Activity | 2017 |
| Description | Rowe: FTD carers meeting (2017) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Research discussion to regional carers |
| Year(s) Of Engagement Activity | 2017 |
| Description | SPM for M/EEG course London (Dr Amirhossein Jafarian - Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Principles of Dynamic Causal Modelling (DCM) | Dr Amirhossein Jafarian | SPM for EEG and MEG |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.youtube.com/watch?v=tD9peFEq1KQ |
| Description | Scientific Programme Chair: Tau2024 Global Conference Prof. James B Rowe |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Served as programme chair. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://istaart.alz.org/events/item/23/127 |
| Description | Scottish Dementia Conference - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | ON-FIRE: a UK-wide study on inflammation in frontotemporal dementia" - Scottish Dementia Conference (Dundee, 14/06/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Session Chair - DPUK Translations 2024 - The Use of Biomarkers in Experimental Medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dementia Platform UK has an annual conference which explores the issues and discoveries emerging in Translational Research for dementia. They bring together people who are working within this vital area of in-human rsearch. Each conference has sessions on trials delivery, working with large data and experimental medicine. All these are crucial to making the discoveries which will deliver the therapeutics and new drugs quickly and at a large scale. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.youtube.com/watch?v=i_Wl7I-WPrQ&list=PLhC6xt3e_5jsuaZvIo5pvSlb19ODAq9hD&index=1 |
| Description | Session Chair-The future of research on the risk factors of FTD |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | On behalf of the Board of Directors and AFTD staff, thank you for attending the Holloway Summit 2025. Over the next two days, you and other brilliant researchers on FTD will talk about the risk factors of FTD - what we know about them today and what we hope to learn tomorrow. The more we understand the causes of FTD, the most likely we are to see future cases reduced to a small number. It can happen, and it can happen in the course of our lives. If you have a previous Holloway Summit, you know that this cause is close to my heart. My husband, Lee Holloway, was diagnosed with FTD in 2017. Lee and I met we when were both working at Cloudflare, the Internet security company that he had co-founded. I was working in communications, while Lee was -- as aFILARYmagazine profile described -- "The resident genius of Cloudflare, the guy who could concentrate for hours, the code slipping at his fingertips. Thanks to Lee's genius, Cloudflare has become possible the most trusted name in the world in terms of cybersecurity. Like so many who others love someone with DFT, I have spent a lot of time and energy ending this disease, both by funding crucial research on DFT and by facilitating groundbreaking discussions among opinion leaders in the field of neurodegeneration. I have seen with my own eyes that we are closer than ever to leave our mark on the science of FTD and that viable treats are on the horizon. Of course, these treatments can only become a reality through collaboration, innovation, and hard, unspeakable scientific work - in short, the work you do every day. Thank you all, once again, for being here. I am proud to support the Holloway Summit since its launch in 2022. And I know that together we are opening the way to a future without FTD. |
| Year(s) Of Engagement Activity | 2025 |
| URL | https://www.theaftd.org/fr/holloway-summit-2025/ |
| Description | Seven lab members (22nd March 2018). 5k for the PSP Association to raise money to support people affected by CBD & PSP, Cambridge, UK. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Run for PSP and CBD to increase awareness. https://www.pspassociation.org.uk/fundraising/5kforpspa/; promoted on twitter |
| Year(s) Of Engagement Activity | 2018 |
| Description | Specialist PSP Sub-group @ Movement Disorder Society International Conference: UHF 7T Imaging |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Expert panel meeting on imaging and Progressive supranuclear palsy. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Sutton Trust MEG Talks - Rebecca Williams (Rowe Group) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Event held at the MRC Cognition Brain Unit |
| Year(s) Of Engagement Activity | 2022 |
| Description | Synaptic Health in Dementia (German Society for Neurology) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | German Society for Neurology |
| Year(s) Of Engagement Activity | 2024 |
| Description | Tactile sensorimotor transformations are reliable over time, but do not generalise across tasks. (Dr Marlou Perquin - Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • Oral talk at the Annual Meeting of the Society for Mathematical Psychology in Tilburg, the Netherlands. The target audience of MathPsych is those interested in mathematical and computational theories of human cognition. Audience size was around 200-400 delegates. Perquin, M.N., Kayser, C., & Heed, T. (2024). Tactile sensorimotor transformations are reliable over time, but do not generalise across tasks. Annual Meeting of the Society for Mathematical Psychology, Tilburg. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://mathpsych.org/conference/15/ |
| Description | Talk at Genetic FTD Meeting, Italy |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International conference |
| Year(s) Of Engagement Activity | 2023 |
| Description | Tau2024 - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Immunophenotypes of PSP, CBS and FTD: blood versus brain?" - Tau2024 (Washington DC, 26/03/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Telegraph on Florence Pugh visit to University of Cambridge with Race Against Dementia - Rowe Group |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Florence Pugh: 'Ever since I posted about dementia, so many people have reached out to me' When she's not busy with her hectic Hollywood schedule, the star is using her voice - and huge following - to support Race Against Dementia |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.telegraph.co.uk/christmas/2024/01/24/florence-pugh-oppenheimer-race-against-dementia-cha... |
| Description | UKDRI Cambridge Seminar - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Inflammation in Frontotemporal Dementia: a multidisciplinary approach" UKDRI Seminar (Cambridge, 06/12/2024) |
| Year(s) Of Engagement Activity | 2024 |
| Description | UKDRI Neuro-immunology Theme - Dr Maura Malpetti (Rowe Group) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | • "Inflammation in Frontotemporal Dementia: a multidisciplinary approach" UKDRI Neuro-immunology Theme Workshop (London, 04/02/2025) |
| Year(s) Of Engagement Activity | 2025 |
| Description | Understanding Dementia: Exploring the Brain - Dr Marlou Perquin (Rowe Group) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | • Oral presentation at Pints of Science 2024, Cambridge at the session 'Understanding Dementia: Exploring the Brain'. The target audience is laypeople who are interested in neuroscientific research of dementia. Audience size was about 50 people. Perquin, M.N. (2024). Why are we variable? |
| Year(s) Of Engagement Activity | 2024 |
| Description | Vazquez, (2017); Half Marathon to raise money and awareness for patients with Progressive Supranuclear Palsy and the PSP Association, Thessaloniki Night Half-Marathon, Greece. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Vazquez Rodriguez, P. (14th October 2017). Half Marathon to raise money and awareness for patients with Progressive Supranuclear Palsy and the PSP Association, Thessaloniki Night Half-Marathon, Greece. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Vazquez/Rowe - Fighting PSP both in and outside the lab. PSP Association Magazine (2017) |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Vazquez Rodriguez, P. (September 2017). Fighting PSP both in and outside the lab. PSP Association Magazine; raise awareness for PSP |
| Year(s) Of Engagement Activity | 2017 |
| Description | Vázquez RodrÃguez; Imaging neuroinflammation in progressive supranuclear palsy and Alzheimer's disease. Talk presented at the PSP Association Annual Study Day (2017) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Vázquez Rodríguez, P. (18th October 2017). Imaging neuroinflammation in progressive supranuclear palsy and Alzheimer's disease. Talk presented at the PSP Association Annual Study Day, Milton Keynes, UK. Was evaluated as best presentation. |
| Year(s) Of Engagement Activity | 2017 |
| Description | WIRED magazine |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Session with WIRED magazine journalists, on cognitive enhancement Education of the public about the ethics, efficacy and evidence for cognitive enhancement |
| Year(s) Of Engagement Activity | 2013 |
| Description | What's new in Frontotemporal Dementia - Sri Lankan Neurology Association |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk to Sri Lanka Neurology association "What's new in Frontotemporal Dementia?" |
| Year(s) Of Engagement Activity | 2023 |