Centre for Integrated research into Musculoskeletal Ageing (CIMA) Renewal

Lead Research Organisation: University of Liverpool
Department Name: Institute of Ageing and Chronic Disease

Abstract

Overview
The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) is a unique team. CIMA brings in a mix of skills from three major U.K. Universities: Liverpool, Newcastle and Sheffield. It helps doctors and lab scientists to work together to grasp:
1) How our muscles, bones and joints change as we age.
2) How this makes some people prone to problems with these tissues such as arthritis and osteoporosis.
3) What each person can do to reduce the risk of developing these problems.

Progress So Far
CIMA was first funded for 5 years in 2012. CIMA has made great progress in figuring out some key processes in muscles, bones and joints as we age. As well as working out what might reduce the risk of developing these problems, we have also done trials of some likely nutritional agents. These might reduce age-related decline in muscles, bones and joints. We have obtained some early evidence that raising vitamin D may help reduce age-related decline, but putting up nitrate intake may not help. A big limit to expanding research in this important area has also been a lack of well-trained researchers and doctors. So the Centre has also developed and run good training courses to meet this need.

Future: Targets, Treatments & Training
This bid is for 5 more years of funding from the Medical Research Council (MRC) and Arthritis Research UK to help build on this work. Our first phase of funding has let the CIMA members spot certain changes to cells- called epigenetic changes. These seem vital in influencing whether muscles, bones and joint tissues decline quickly or slowly as we age. We plan to do a linked research programme across Liverpool, Newcastle and Sheffield. This will seek to work out the importance of these changes and whether we can modify the changes to reduce the risk of getting muscle, bone and joint problems. We will also work together to look more closely at whether nutrition and exercise can prevent or reduce the risk of these problems. We also plan to expand our training programme so more basic scientists and doctors can do excellent research into these problems. Key results will be shared in papers and meetings. More funding bids will be made to do this work.

Patient View
People with arthritis have helped to shape this bid. By joining a series of "Arthritis Matters" Public Engagement events, for example. These have helped the public grasp CIMA's research and shape future priorities. Above all this includes a grasp of new arthritis treatments and how study findings can benefit patients. We also asked a group of 15 patients to advise on the final lay summary. We think talking to patients often about research and listening to their views makes for better research.

Better Engagement
Going forward, patients and the public will continue to be actively involved by providing insight and valued feedback in many ways. Face to face meetings will remain a key part. And more events will be used, including local, national and global schemes. There will be new work with schools, to share CIMA's work, inspire new ideas and nurture talent. The VOICE North digital platform will support this across the Centre and more widely. The CIMA website will also be kept up to date and advances shared on Twitter. We know most older people don't use these yet, but that could change quickly as access gets easier and cheaper. We expect young people to help make solutions for this. We will also increase our work with drug companies, local authorities and the NHS. This will allow us to develop ways to make sure our findings are quickly put into practice to benefit older people. Arthritis is also one of a key number of conditions included in the NIHR James Lind Alliance Priority Setting Partnership on Ageing and Multiple conditions, led by Newcastle University. This will provide more chances for patients who have arthritis to be involved and link to CIMA.

Technical Summary

The MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) brings together scientific and clinical expertise in different disciplines from the universities of Liverpool, Newcastle and Sheffield. Formed in 2012, CIMA has developed an integrated approach to study the effects of ageing on the musculoskeletal system, which has been demonstrably successful. CIMA has focussed activities in areas of critical mass where collaborations have provided enhanced value. These include the role of epigenetic changes in cells and tissues affected by musculoskeletal ageing, development of an assessment protocol for monitoring age-related decline in the musculoskeletal system (the CIMA Toolkit), and proof of principle pre-clinical and human studies to identify interventions that reduce the deleterious effects of ageing on the musculoskeletal system. CIMA has developed an innovative graduate training programme and undertaken well-received public engagement activities. The revised CIMA strategy will be increasingly translational, but informed by basic research. Specifically, we will; determine how epigenetic changes in the ageing musculoskeletal system influence the risk of musculoskeletal disorders, the effect of modification of epigenetic changes on musculoskeletal function, and the effect of lifestyle changes on epigenetic marks and molecules; design and implement interventions based on physical activity, nutrition, anti-inflammatory or age-retarding agents on decline of the ageing musculoskeletal system; extend the CIMA training programme to increase MRes, PhD and clinical training, and; develop engagement and impact activities to increase involvement of patients and the older population, and work with industry and other partners to maximise translation of our research discoveries. Finally, it will provide a resilience that will ensure musculoskeletal ageing moves to the centre of medical research activities within and beyond the UK.

Planned Impact

CIMA renewal will contribute to all key impacts, including advancement of scientific knowledge, health and wellbeing, economic competitiveness, policy development and the provision of skilled people to the workforce. Our activities will supplement and complement existing programmes, harnessing the best practice at each of the centres to deliver excellence at all. In every area, the process will be a dialogue or platform of co-discovery, where both sides benefit from improved knowledge and understanding.

Benefits are targeted to the aging population and those who have conditions that are associated with accelerated ageing, for example those with systemic and local joint inflammation.

Potential impacts to the ageing population from advances in scientific knowledge include:
- direct benefits including learning and empowerment from contributing to the design and delivery of studies
- Improved ability to monitor age-related decline of the entire musculoskeletal system and the effects of potential interventions to reduce this through use of the CIMA Toolkit
- benefits from involvement in effective shared decision making using tools like FRAX for assessing fracture risk.
- wider understanding of musculoskeletal ageing from PPI and patient engagement, VOICENorth (Quote: 'We are volunteering the accumulated knowledge we have gathered over our entire life'.)
- better information about healthy ageing and how to achieve it from better trained experts and improved personal engagement from platforms including VOICENorth online and the MOOC.- enhanced understanding of mechanisms and targets, feeding directly into accelerated novel drug identification and development
- refining outcomes and delivering interventions that improve care and both scientific and clinical practice

Impacts for health and wellbeing include:
- improved pain, function and quality of life from participation in clinical trials and accruing to the wider population once interventions are proven effective
- high standard of care related to being involved in a clinical trial
- avoidance of harm from better targeting of therapy and toxicity identification of widely used drugs, such as paracetamol
- improved treatment options and prognostication

Impacts on economic competitiveness include:
- investment in research, delivering economic benefits for the centre and wider economy by a) health gains net of the cost of delivery, b) GDP gains from the activity and further stimulated activity
- these will come from new biomarkers, assessment tools, nutritional supplements and drugs, training and engagement activity

Impacts on policy development will include:
- benefits of more effective care, driven by NICE and other guidelines
- briefing MPs; advising expert panels, select committees, the Foresight programme (such as 'Future of an Ageing Population', 2016); WHO
- collaboration and advisory work for industry, including the CIMA Industrial Strategy Board

Impacts on provision of skilled workforce will include:
- better education and proactive identification of talented scientists from early identification and support for innovation from school sixth form onwards
- enhanced awareness of musculoskeletal ageing in trainee scientists and clinicians arising from exposure to the CIMA MOOC
- support for MRes and PhD students, postdoctoral and tenured scientists, who will contribute to training the next generation, specifically training to increase understanding of PPI and engagement.
- closer industry links leading to both funding of education and scientific posts by industry and flow of highly skilled workforce between academia and industry

Publications

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Alam U (2017) Diabetic Neuropathy and Gait: A Review. in Diabetes therapy : research, treatment and education of diabetes and related disorders

 
Description Mathers/Kemp - Expert witness at House of Lords Science and Technology Select Committee inquiry into Ageing: Science, Technology and Healthy Living.
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://parliamentlive.tv/event/index/4903fe3f-7449-4674-822b-f67828a4f1f9?in=10:27:51
 
Guideline Title European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Description McCloskey - Guidance for management of osteoporosis
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Unknown
 
Description 'Small non-coding RNAs to stratify osteoarthritis in the horse
Amount £133,000 (GBP)
Organisation Horse Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK (Bou-Gharios)
Amount £251,000 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ARUK (Bou-Gharios)
Amount £413,430 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Aintree Arthritis Trust (Moots, Wright, Edwards)
Amount £33,000 (GBP)
Organisation Aintree Arthritis Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Aquaporins: A hole in our understanding of hydrogen peroxide regulation
Amount £385,108 (GBP)
Funding ID BB/T002115/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2019 
End 08/2022
 
Description Association of Physicians (Hannan)
Amount £19,850 (GBP)
Organisation Association of Physicians of Great Britain and Ireland 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description BBSRC CRISPR-interference Screening Centre (Eeden, Renshaw, Wilkinson)
Amount £428,223 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description BBSRC In Vivo Skills award (Pekovic-Vaughan et al)
Amount £12,300 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description BBSRC Summer studentship (Peffers)
Amount £2,500 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description BRC MIlkMAN (Granic, Stevenson, Aspray, Sayer)
Amount £91,041 (GBP)
Organisation British Retail Consortium 
Sector Private
Country United Kingdom
Start  
 
Description Biomarkers to predict response to biologic therapy for the stratification of patients to appropriate therapy in rheumatoid arthritis
Amount £6,153 (GBP)
Organisation Illix Ltd 
Sector Private
Country United Kingdom
Start  
 
Description Biomarkers to predict response to biologic therapy for the stratification of patients to appropriate therapy in rheumatoid arthritis
Amount £24,612 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description CRUK Pioneer Award (Zglinicki)
Amount £200,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Circadian rhythms and the control of NRF2-based antioxidant signalling as a therapeutic target in dermal tissue repair and pathological wound healing
Amount £448,442 (GBP)
Funding ID MR/P003311/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description Clinical Consequences of Adult-Presenting Hypophosphatasia with Special Focus on Gait, Bone Microarchitecture and Cognition: the PORTRAIT Study
Amount £222,719 (GBP)
Organisation Alexion 
Sector Private
Country Germany
Start  
 
Description Cuthbertson - Multi-organ abnormality prevalence in type 2 diabetes mellitus
Amount £165,166 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start  
 
Description D'Aout - Making better fitting leg prostheses: quantifying in-socket motion of the stump using biplanar X-Ray videography.
Amount £9,906 (GBP)
Organisation University of Liverpool 
Sector Academic/University
Country United Kingdom
Start  
 
Description D'Aout - ODA Research Seed Fund
Amount £5,730 (GBP)
Organisation University of Liverpool 
Sector Academic/University
Country United Kingdom
Start  
 
Description D'Aout - Translational Research Access Programme 2019
Amount £62,426 (GBP)
Organisation University of Liverpool 
Sector Academic/University
Country United Kingdom
Start  
 
Description D'Aout- Machine learning for automatic gait detection in mice
Amount £2,800 (GBP)
Organisation University of Liverpool 
Sector Academic/University
Country United Kingdom
Start  
 
Description Dowager Countees Eleanor Peel Trust (Henstock)
Amount £13,500 (GBP)
Organisation The Dowager Countess Eleanor Peel Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Dunhill Medical Trust (Clegg, Screen, Thorpe)
Amount £250,000 (GBP)
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Dunhill Medical Trust (Whysall)
Amount £197,222 (GBP)
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description EU Funding Innovative Medicines Initiative
Amount € 12,000,000 (EUR)
Organisation European Commission 
Department Innovative Medicines Initiative (IMI)
Sector Public
Country Belgium
Start  
 
Description EU Marie Curie (Bernut, Renshaw)
Amount £161,000 (GBP)
Organisation Marie Curie 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Eastell- Clinical utility of PINP: the POSE Study
Amount £91,000 (GBP)
Organisation Roche Pharmaceuticals 
Sector Private
Country Global
Start  
 
Description Evaluation of senolytic interventions in skin ageing
Amount £361,353 (GBP)
Funding ID BB/S006710/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 02/2019 
End 01/2022
 
Description Exploiting microvesicle small non-coding RNA and protein cargo in osteoarthritis for early diagnosis and treatment
Amount £272,093 (GBP)
Organisation Horserace Betting Levy Board 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Exploiting microvesicle small non-coding RNA and protein cargo in osteoarthritis for early diagnosis and treatment'
Amount £272,000 (GBP)
Organisation Horserace Betting Levy Board 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Exploiting microvesicle small non-coding RNA cargo in osteoarthritis for early diagnosis and treatment
Amount £272,094 (GBP)
Organisation Horserace Betting Levy Board 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Extracellular vesicles as a treatment for osteoarthritis
Amount £177,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description FIDELIO
Amount £3,500,000 (GBP)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start  
 
Description Frontier Engineering: Progression Grant in Modelling complex and partially identified engineering problems. Application to the musculoskeletal system.
Amount £757,886 (GBP)
Funding ID EP/S032940/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2019 
End 08/2021
 
Description HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE)
Amount £263,127 (GBP)
Funding ID BB/V019821/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2021 
End 03/2024
 
Description Health Education England NE (Birrell)
Amount £49,500 (GBP)
Organisation Health Education England 
Sector Public
Country United Kingdom
Start  
 
Description Healthspan screening in C. Elegans
Amount £30,000 (GBP)
Organisation European Commission 
Department European Regional Development Fund (ERDF)
Sector Public
Country Belgium
Start  
 
Description Hedgehog signalling in ligamentocytes: the role of mechanical loading
Amount £10,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start  
 
Description How does ageing affect post-transcriptional gene regulation in articular cartilage?
Amount £238,786 (GBP)
Funding ID RPGF2002/217 
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2020 
End 09/2023
 
Description Hydrogel-encapsulation for preservation of mitochondria
Amount £20,000 (GBP)
Organisation European Commission 
Department European Regional Development Fund (ERDF)
Sector Public
Country Belgium
Start  
 
Description INSPIRE
Amount £10,000 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Identification of cytokines that drive progression of fibrosis in Dupuytren's disease: therapeutic opportunities with biologics
Amount £177,383 (GBP)
Funding ID 21809 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2018 
End 07/2020
 
Description Illix Ltd (Wright, Moots, Edwards)
Amount £55,994 (GBP)
Organisation Illix Ltd 
Sector Private
Country United Kingdom
Start  
 
Description Innovate UK (Hill)
Amount £350,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start  
 
Description Isanejad - Testing and exploring the application of Ambient Assisted Living Technology prototype
Amount £9,000 (GBP)
Organisation University of Liverpool 
Sector Academic/University
Country United Kingdom
Start  
 
Description JGW Patterson Foundation (Sorial/Loughlin/Deehan)
Amount £52,000 (GBP)
Organisation The JGW Patterson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Japan Partnering Award: The paraventricular nucleus of the hypothalamus; networks and mathematical models.
Amount £50,755 (GBP)
Funding ID BB/S020772/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 06/2023
 
Description KTP Senolytic drug development and Validation
Amount £180,643 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start  
 
Description KTP award (Miwa/Zglinicki)
Amount £181,000 (GBP)
Organisation Knowledge Transfer Partnerships 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description MICROAGE: Microgravity as a model for accelerated skeletal muscle ageing
Amount £1,165,606 (GBP)
Funding ID ST/S003061/1 
Organisation UK Space Agency 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2021
 
Description MRC (Renshaw et al)
Amount £686,584 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description MRC Project grant (Renshaw)
Amount £691,917 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description MRC World Class Labs Capital Funding
Amount £83,448 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2020 
End 03/2021
 
Description MRC iCASE Studentships (Renshaw et al)
Amount £289,023 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description MRC/ARUK CMAR Studentship (Peffers, Jones)
Amount £120,000 (GBP)
Organisation Versus Arthritis 
Department Arthritis Research UK Centre for Musculoskeletal Ageing Research
Sector Academic/University
Country United Kingdom
Start  
 
Description Metabolic reprogramming of human neutrophils during inflammation
Amount £143,064 (GBP)
Funding ID 22193 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2019 
End 09/2023
 
Description MiRNA regulation of Chondrocyte function
Amount £130,000 (GBP)
Organisation Horse Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Mitochondria as a key regulator of muscle loss in microgravity and during ageing on earth (MicroAge II) - a feasibility study
Amount £120,831 (GBP)
Funding ID ST/V003917/1 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 10/2020 
End 03/2021
 
Description Miwa - Healthspan screening in C. Elegans ARROW Grant
Amount £30,000 (GBP)
Organisation European Commission 
Department European Regional Development Fund (ERDF)
Sector Public
Country Belgium
Start  
 
Description Miwa - Hydrogel-encapsulation for preservation of mitochondria
Amount £20,000 (GBP)
Organisation European Commission 
Department European Regional Development Fund (ERDF)
Sector Public
Country Belgium
Start  
 
Description Molecular genetic and epigenetic analysis of the chromosome 4p16.3 osteoarthritis risk locus
Amount £48,722 (GBP)
Organisation The JGW Patterson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Multi-modal high resolution preclinical PET+SPECT+CT scanner
Amount £939,518 (GBP)
Funding ID 208389/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2022
 
Description NC3R grant (Shanley)
Amount £389,043 (GBP)
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description NIHR HTA (Meher, Hannan)
Amount £2,100,000 (GBP)
Organisation National Institute for Health Research 
Department Health Technology Assessment Programme (HTA)
Sector Public
Country United Kingdom
Start  
 
Description NIHR Newc BRC Project Grant (Birrell)
Amount £60,824 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Newcastle Hospital Trust (Young, Loughlin)
Amount £44,000 (GBP)
Organisation Newcastle upon Tyne Hospitals NHS Foundation Trust 
Sector Academic/University
Country United Kingdom
Start  
 
Description Newcastle University Group Consultation Virtual Hub: Managing & Preventing Severe Disability Across the UK.
Amount £250,000 (GBP)
Organisation Sir Jules Thorn Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Nittobo Evaluation of assay (Eastell)
Amount £70,000 (GBP)
Organisation Nittobo 
Sector Private
Country Japan
Start  
 
Description Optimising the functional potential of serpins to block cartilage breakdown: Implications for novel therapeutics for osteoarthritis
Amount £398,127 (GBP)
Funding ID 22418 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2020 
End 04/2025
 
Description Overcoming the barriers to maximize the commercial potential for vitamin D enriched eggs
Amount £161,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start  
 
Description PROvision of braces for Patients with knee OsteoArthritis (PROP OA): a randomised controlled trial
Amount £1,622,564 (GBP)
Funding ID HTA/16/160/03 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2018 
End 11/2022
 
Description Peffers - Determining predictive metabolomic biomarkers for meniscal injuries in dogs with cranial cruciate ligament rupture using stifle joint synovial fluid
Amount £32,927 (GBP)
Organisation Petsavers Charitable Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Peffers - INSPIRE award
Amount £20,000 (GBP)
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Peffers - Investigation of the structure and cargo of extracellular vesicles from mesenchymal stem cells used for treatment of osteoarthritis in horses
Amount £10,000 (GBP)
Organisation Horserace Betting Levy Board 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Peffers -Exploring mechanisms of autologous biological therapies for tendon injury repair in the horse
Amount £264,725 (GBP)
Organisation Horserace Betting Levy Board 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Precision pathobiology for disease models.
Amount € 998,627 (EUR)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start  
 
Description Preventing falls in older people by an innovative connected shoe: development & biomechanics study
Amount £575,432 (GBP)
Funding ID 104142 
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2020
 
Description Preventing falls in older people by an innovative connected shoe: development & biomechanics study
Amount £74,567,600 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start  
 
Description Rapid integrated tendon repair system
Amount £98,866 (GBP)
Funding ID 22032 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2019 
End 08/2020
 
Description Role(s) of Fibrillin-1 in post-traumatic osteoarthritis
Amount £58,622 (GBP)
Funding ID 22451 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2019 
End 09/2021
 
Description Royal College Surgeons Edinburgh (Sorial/Loughlin)
Amount £60,000 (GBP)
Organisation The Royal College of Surgeons of Edinburgh 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Sarcoma UK (Peffers, Balaskas)
Amount £20,750 (GBP)
Organisation Sarcoma UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Sorial - CRISPR/Cas9 human stem-cell modulation for personalised arthritis therapeutics
Amount £72,500 (GBP)
Organisation US-UK Fulbright Commission 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Sorial - CRISPR/Cas9 human stem-cell modulation for personalised arthritis therapeutics
Amount £70,733 (GBP)
Organisation Royal College of Surgeons of England 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Tew - Post transcriptional gene regulation in ageing cartilage
Amount £238,786 (GBP)
Organisation The Dunhill Medical Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description UK Space Agency MICROAGE (Jackson, McArdle, Henstock, Hoettges)
Amount £1,291,511 (GBP)
Organisation UK Space Agency 
Sector Public
Country United Kingdom
Start 11/2018 
End 11/2021
 
Description Understanding the mechanisms and therapeutic potential of targeting biological clocks in Systemic Sclerosis
Amount £20,598 (GBP)
Funding ID M709 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 04/2021
 
Description Uni of Georgia pump-priming award (Henstock)
Amount £1,000 (GBP)
Organisation University of Georgia 
Sector Academic/University
Country United States
Start  
 
Description University of Liverpool (Pefers)
Amount £6,300 (GBP)
Organisation University of Liverpool 
Sector Academic/University
Country United Kingdom
Start  
 
Description Using Capture C analysis and CRISPR-Cas9 mediated genomic editing to identify the target genes of OA-associated chondrogenic enhancers
Amount £62,179 (GBP)
Organisation The JGW Patterson Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Utility of PINP to monitor osteoporosis treatment in clinical practice by non-specialist practitioners, the POSE study (PINP and Osteoporosis in Sheffield Evaluation)
Amount £93,824 (GBP)
Organisation F. Hoffmann-La Roche AG 
Department Roche Diagnostics
Sector Private
Country Global
Start  
 
Description Von Zglinicki - Pre-clinical validation of novel candidate senolytics
Amount £73,000 (GBP)
Organisation United Kingdom Research and Innovation 
Department UK SPINE Knowledge Exchange
Sector Public
Country United Kingdom
Start  
 
Description Wellcome Trust Summer Scholarship (Henstock)
Amount £2,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wilkinson - A Randomized Clinical Trial of a Modular Cementless Acetabular Metal on Poly Component versus a Monoblock Cementless Titanium Shell with Ceramic on Ceramic Bearing and
Amount £42,689 (GBP)
Organisation University of Ottawa 
Department Ottawa Health Research Institute
Sector Academic/University
Country Canada
Start  
 
Description Wilkinson - Functional genomics of osteoarthritis
Amount £146,312 (GBP)
Organisation Helmholtz Association of German Research Centres 
Department Helmholtz Zentrum Munchen
Sector Academic/University
Country Germany
Start  
 
Title Fibrotic tissue and healthy ligament 
Description Human tissue samples derived from surgery as well as cell cultures, tissue extracts and RNA/cDNA derived thereof. 
Type Of Material Biological samples 
Year Produced 2018 
Provided To Others? No  
Impact Contributed to CIMA PhD completion and ongoing MRC and Versus Arthritis funded projects. 
 
Title Model of age-related bone loss 
Description Computational model to investigate age-related bone loss 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2018 
Provided To Others? Yes  
Impact This featured as "Model of the month" in Nov 2018 in Biomodels database 
 
Title characterisation of epigenomic changes during chondrogenesis 
Description Computational model to investigate age-related changes in signalling pathways in OA 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2019 
Provided To Others? Yes  
Impact TBC 
 
Title Characterisation of epigenomic changes during chondrogenesis 
Description ChIP-seq data from MSC chondrogenesis 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact Publication submitted 
 
Title FRAX 2 dataset 
Description Tool to develop an updated calculation engine for the FRAX tool 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact In process 
 
Title Proteomic analysis of neutrophil extracellular traps (healthy control, rheumatoid arthritis, systemic lupus erythematosus)_C4PR_LIV 
Description NET proteomics dataset 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact TBC 
 
Title Spatio-Temporal Atlas of Bone Mineral Density Ageing 
Description technique utilises an alternating minimisation technique to map the observed bone density measurements into a latent standardised space 
Type Of Material Data analysis technique 
Year Produced 2018 
Provided To Others? Yes  
Impact Publication 
 
Description Birrell - BSLM Virtual Group Consultations Webinars: Continuity of Care During Covid 
Organisation British Society of Lifestyle Medicine
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Led by Fraser Birrell
Collaborator Contribution Rotation of chairs from UK, USA, Australia. International panel of experts. Sharing videos of webinars on websites, supporting spread & data sharing.
Impact Paper published; Multidisciplinary, including all clinical groups, management, indutry, education, research
Start Year 2020
 
Description Hill - Newcastle collaboration TULIPS (Towards and Understanding of Life and Living on Old Age) consortium 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data analysis of oldest old databases, publications
Collaborator Contribution Joint data analysis nd publications
Impact Collaborative meetings in Auckland (2018) and Tokyo (2019), papers in preparation for submission.
Start Year 2018
 
Description IOFIFCC Working group 
Organisation International Osteoporosis Foundation
Country Switzerland 
Sector Charity/Non Profit 
PI Contribution Bone turnover markers, collab to produce guidelines on the use of markers
Collaborator Contribution As above
Impact As above
Start Year 2018
 
Description McCloskey - Amgen/UCSF CrystalBone - Predicting Short-term Fracture Risk with Deep Learning 
Organisation Amgen Inc
Country United States 
Sector Private 
PI Contribution Research design advice, data interpretation and manuscript writing
Collaborator Contribution Research design and conduct, data interpretation and manuscript writing
Impact Not yet
Start Year 2019
 
Description McCloskey - McGill gSOS - development and clinical utility of a polygenic score for a measure of bone mass 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Assessing fracture risk by FRAX in cohorts used in discovery and validation testing of gSOS; contribution to data interpretation and report/manuscript writing
Collaborator Contribution Developing and validating the gSOS polygenic score. Contribution to data interpretation and report/manuscript writing
Impact https://doi.org/10.1101/413716
Start Year 2017
 
Description Pekovic-Vaughn - Liverpool collaboration Mathematical modelling of non-canonical NRF2 role in circadian clock regulation 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution provided experimental data from various musculoskeletal tissues around the clock
Collaborator Contribution provided experimental data from various musculoskeletal tissues around the clock
Impact two papers in preparation
Start Year 2019
 
Description Poulet - Florida Atlantic University New MMP13 inhibitor against osteoarthritis 
Organisation Florida Atlantic University
Country United States 
Sector Academic/University 
PI Contribution We performed the study and analysis (involving mouse osteoarthritis induction, treatment, tissue collection and analysis).
Collaborator Contribution supply of treatment and expertise on kinetics of the drug. Will also analyse the serum from these mice for in vivo kinetics of the treatment.
Impact tbc (expected publication and future grant applications); collaboration between Biomedical scientist (mouse models of disease) and biochemist.
Start Year 2019
 
Description Wright - CIMA MRes project 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Transcriptomics analysis
Collaborator Contribution Data
Impact not yet
Start Year 2021
 
Description Wright- Ogbechi transcriptomics 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Transcriptomics analysis
Collaborator Contribution Data
Impact not yet
Start Year 2020
 
Title HPpQCT heel assessment 
Description Protocol for scanning and analysing heel scans 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2018
Development Status On hold
Impact Two publications 
 
Title Happy Egg with added vitamin D 
Description A vitamin D enriched egg product which was developed as a result of an Innovate funded project in 2015 Led to an additional Innovate UK funded project to explore the wider commercial potential for vitamin D enriched eggs 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2018
Development Status Closed
Impact See above 
 
Title Novel anti-inflammatory compounds 
Description Compounds originally developed in van 't Hof lab, now licensed to Modern Biosciences and Johnson & Johnson. advised on clinical trials 
Type Therapeutic Intervention - Drug
Current Stage Of Development Late clinical evaluation
Year Development Stage Completed 2019
Development Status Under active development/distribution
Impact TBC 
 
Description Better Together: The Evidence Behind the Headlines A Group Consultation Public Engagement Event on Care and Research 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact An opportunity to ask health related questions, experience how a group consultation works and hear talks from experts in muskuloskeletal research.
25 attending; estimate 500 online
Highly interactive session with questions from every attendeee. Excellent feedback from speakers and patients
Enthusiasm for similar event at national CIMA meeting
Year(s) Of Engagement Activity 2019
 
Description Dupuytren's PPI panel 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Patients heard about, provided feedback on and discussed current research, and were given tours of the laboratories. Contacts made with new surgical team via patient society, resulting in additional site being added to the study. Patients were keen to return to the next panel meeting. Researchers asked to contribute to webinar for patients.
Year(s) Of Engagement Activity 2019
 
Description Dupuytren's patient involvement panel events 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact To discuss research findings and future plans and obtain patient perspectives on translation of results to treatment options as well as the wider environment influencing patient experience. The activities comprised patient involvement panel events lasting 3-4 hours and held in our research building. 6-12 patients or carers were present at each event. The president of the British Dupuytren's Society was also present, providing valuable relevant current information on clinical treatment options, research topics, broader patient perspectives and recent developments in the area. The events included an introduction to the research topic/history, presentation/discussion of research findings, discussion of preferred treatment options, and paper patient and feedback surveys. After each event participants were offered a laboratory tour which was taken up at least once by all participants and sparked additional discussions.
Year(s) Of Engagement Activity 2018,2019,2020
 
Description Dupuytren's research webinar 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact To communicate current Dupuytren's research in the UK to patients
; The activity was participation in a research webinar organised by the British Dupuytren's Society. This involved a presentation broadcast to those registered for the webinar, along with presentations from 3 other research teams. The webinar was recorded and uploaded to YouTube. The estimate of the number of people reached was based on the number dialing in to the webinar plus the number of views on YouTube as of 21st April 2020. Dr Elizabeth Laird and Dr Emma Beamish gave the presentation.
Year(s) Of Engagement Activity 2019
 
Description Exercise and nutrition for healthy ageing workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact share information and improve understanding ; "older adults from the local community came to talk by E Stevenson and Ellie Hayes (CIMA PhD student) Q&A afterwards.
asked for further workshops and resources for the local gym "
Year(s) Of Engagement Activity 2019
 
Description Genetics Matters - 3/6 scientists to participate in an activity to celebrate Rare Diseases Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Aim was to highlight the importance of scientists, doctors, patient organisations and the public coming together to generate the critical mass and instigate change in rare disease research and in life of the patients and communities.;
there were about 10 tables with scientists presenting their research, and also some charities. There was a rotating system and a new group came to our table every 15 minutes. This enabled to have a personal conversation with them about science, but also to ask them about their lives to live with a rare disease.
Year(s) Of Engagement Activity 2020
 
Description Group Consultation National Spread 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact National publicity associated with RCGP meeting 5/10/18: Front page news: The Sun, Daily Telegraph, Daily Mail, BBC national news BBC1, Radio 4, online
Year(s) Of Engagement Activity 2018
 
Description Hosting 6th form students lab visits 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact To discuss and demonstrate biomedical research, Lots of questions regarding research, how one does it, and its role in science teaching and in society at large. Students enthused to apply to undergraduate university courses
Year(s) Of Engagement Activity 2019
 
Description International Paget's Disease Awereness Day 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact pariticipation through RLBUHT website and social media
Year(s) Of Engagement Activity 2019
 
Description Intro to foot function and ageing for fashion students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Liverpool university, fashion students
Year(s) Of Engagement Activity 2019
 
Description Lab visits for 6th form students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Lots of questions regarding research, how one does it, and its role in science teaching and in society at large Students enthused to apply to undergraduate university courses
Year(s) Of Engagement Activity 2019
 
Description Launch of https://jointcalc.shef.ac.uk/ website - patient decision aid for joint replacement 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact to promote shared decision making, better informed decision making for patients
Year(s) Of Engagement Activity 2019
 
Description MRC Festival of Medical Research workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact To share information, to stimulate thinking, and to improve understanding. Considerable Q&A regarding musculoskeletal diseases and how to maintain musculoskeletal health. Have been contacted by participants who wish to vist the lab and hear more. Have subsequently hosted a patient in the lab.
Year(s) Of Engagement Activity 2019
 
Description MRC Festival of Science engagement event, Newcastle 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact 100 people attended and many asked questions on the role of nutrition, especially vitamin D in bone health
Year(s) Of Engagement Activity 2018
 
Description Metabolic health, rather than weight status, contributes to endothelial dysfunction: a comparison of weight/metabolic health related phenotypes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Metabolic health, rather than weight status, contributes to endothelial dysfunction: a comparison of weight/metabolic health related phenotypes
Year(s) Of Engagement Activity 2019
URL https://www.easd.org/virtualmeeting/home.html#!resources/metabolic-health-rather-than-obesity-status...
 
Description Monthly Group Consultations 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Share evidence underpinning best practice & latest research developments,
13-23 patients per clinic (1000 per year)
Better understanding of core management strategy and latest evidence, translating into better care and empowerment
High remission rates and evidence of enhanced self- care
Year(s) Of Engagement Activity 2018,2019
 
Description Musculoskeletal biology patient involvement group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact 6 people with arthritis attended PPI meetings, academics presented project ideas, project results etc and these were discussed as a group Excellent feedback from patient group and requests for more activities
Year(s) Of Engagement Activity 2018,2019
 
Description Musculoskeletal biology patient involvement group Chair and Student rep 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Discussions around musculoskeletal research plans, and dissemination of research data, increased understanding of research activities in Liverpool and CIMA; 5 people living with arthritis attended PPI meetings, academics presented project ideas, project results etc and these were discussed as a group, at Feb 20 meeting the CIMA Mres students presented their projects for discussion. Excellent feedback from patient group and requests for more activities
Year(s) Of Engagement Activity 2020
 
Description Osteoporosis 2000 Support Group talk & Q&A 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact Information sharing
Year(s) Of Engagement Activity 2020
 
Description PPI seminar hosted Bethan Jones UWE and her patient partner, who discussed patient participation in research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact 2 patients have expressed a desire to partner PhD students in the institute
Year(s) Of Engagement Activity 2019
 
Description Public engagement at stand at Windsor Horse Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 250 attened the stand and engeged on our equine foot balance activity engage with public interested in equine lameness and foot balance
Year(s) Of Engagement Activity 2019
 
Description Public engagement stand at Liverpool Horse Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 500 people attende the stand over 3 days which had a number of undergard vet students presenting vet related issues including musculoskeletal
engage with potential vet students, made conatct with an undergrad who is now my Masters student, invited to give a talk at Chester University on my work
Year(s) Of Engagement Activity 2018
 
Description Session on lessons for healthy ageing from ageing research 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Panel was Tom Kirkwood, Joao Passos, John Mathers and Malcolom Jackson
Year(s) Of Engagement Activity 2019
 
Description Sky TV news item on UKSA award 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with research team members and filming of laboratory activies
Year(s) Of Engagement Activity 2018
 
Description Talk on surgical aspects of Paget's disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact to share information, promoted discussion amongst participants. lecture posted on Paget's association website
Year(s) Of Engagement Activity 2019
 
Description Virtual Group Consultations Webinars: Continuity of Care During Covid 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Patients, carers and/or patient groups
Results and Impact Share experience of virtual group consultations; Sharing of best practice & supporting clinical teams to deliver virtual group consultations. Each team agreeing to nominate 1-2 patient leads will feed into a creation of a global patient panel
Year(s) Of Engagement Activity 2020,2021
 
Description What really moves you? Public lectures on the wonders of your musculoskeletal system - public talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Oral presentation to approx 60-70 general public attendees ranging in age from primary school to retired adults, followed by questions and answers
Year(s) Of Engagement Activity 2016
 
Description World Arthritis Day Blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact TBC
Year(s) Of Engagement Activity 2018