Epidemiological and statistical research on health problems of low and middle-income countries: MRC Tropical Epidemiology Group (TEG)
Lead Research Organisation:
London Sch of Hygiene and Trop Medicine
Department Name: Epidemiology and Population Health
Abstract
The mission of the MRC Tropical Epidemiology Group (TEG) is to help improve health in low- and middle-income countries (LMICs), by conducting research that identifies and evaluates effective interventions.
Infectious diseases, including malaria, HIV, tuberculosis (TB) and neglected tropical diseases (NTDs), remain a main focus of our research, as they are the leading causes of ill-health in Africa. In the next grant period, we will expand our research on emerging diseases, adolescent health and non-communicable diseases - particularly hypertension, diabetes and chronic obstructive pulmonary disease, which are major disease problems in LMICs. Our research focuses on conditions that are major causes of ill-health, and for which improved prevention or treatment leads directly to improved economic and social outcomes. The importance of these issues to the UK is highlighted in the 2015 Government strategy for overseas aid, on tackling global challenges in the national interest.
The scale-up of malaria control tools, primarily long-lasting insecticidal nets, and effective combination therapies, has prevented an estimated 663 million clinical malaria cases in sub-Saharan Africa since 2000, and has made malaria elimination an achievable goal in some countries. However, these gains may be threatened by insecticide resistance, drug-resistance, and resource-constraints. Within the next grant period, our focus will be on evaluating new tools, combining new and existing control strategies, and investigating sustainable and more effective deployment of these strategies.
For HIV, we focus on the goal that 90% of those living with HIV know their status, 90% of known HIV-positive individuals receive sustained ART, and 90% of individuals on ART have durable viral suppression. For example, we are leading a major trial in South Africa and Zambia to evaluate the impact of a combination prevention intervention on new cases of HIV in the community. The intervention includes household-based HIV testing and linkage-to-health services by community care providers, and immediate initiation of treatment delivered through routine healthcare services.
TEG research on TB includes studies to evaluate improved TB treatment strategies, improved diagnosis, prevention and control of drug-resistant TB, improved TB case finding and prevention, and evaluation of structural interventions (social support and monetary incentives) to control TB. For example, we are working on a trial to evaluate an improved electronic medication device for TB patients to reduce treatment failure and subsequent recurrence/retreatment in the absence of directly observed treatment.
We will continue our long-standing work on intervention strategies for the control and elimination of NTDs, and our more recent involvement in the control of outbreaks such as the Ebola and Zika virus outbreaks. We will also continue our work on the effectiveness of lay-health worker interventions to treat common mental disorders (depression and anxiety), focusing particularly on treatment of these conditions among adolescents, in whom over half of mental health disorders start.
Through the MRC Programme Grant, we leverage additional funding for research projects and support salaries for around 30 statisticians and epidemiologists, based at LSHTM. The grant is critical to enable us to recruit and retain these scientists, who have disease and methodological expertise in the design and analysis of epidemiological studies in LMICs. We collaborate with the MRC Units in The Gambia and Uganda, and over 50 other research institutes in LMICs. We will continue our initiatives to increase capacity in medical statistics in sub-Saharan Africa, for example by expanding the MRC TEG Fellowship scheme, which to date has trained 17 medical statisticians through a Masters in Medical Statistics at LSHTM, followed by a placement year. All are now working as medical statisticians in Africa.
Infectious diseases, including malaria, HIV, tuberculosis (TB) and neglected tropical diseases (NTDs), remain a main focus of our research, as they are the leading causes of ill-health in Africa. In the next grant period, we will expand our research on emerging diseases, adolescent health and non-communicable diseases - particularly hypertension, diabetes and chronic obstructive pulmonary disease, which are major disease problems in LMICs. Our research focuses on conditions that are major causes of ill-health, and for which improved prevention or treatment leads directly to improved economic and social outcomes. The importance of these issues to the UK is highlighted in the 2015 Government strategy for overseas aid, on tackling global challenges in the national interest.
The scale-up of malaria control tools, primarily long-lasting insecticidal nets, and effective combination therapies, has prevented an estimated 663 million clinical malaria cases in sub-Saharan Africa since 2000, and has made malaria elimination an achievable goal in some countries. However, these gains may be threatened by insecticide resistance, drug-resistance, and resource-constraints. Within the next grant period, our focus will be on evaluating new tools, combining new and existing control strategies, and investigating sustainable and more effective deployment of these strategies.
For HIV, we focus on the goal that 90% of those living with HIV know their status, 90% of known HIV-positive individuals receive sustained ART, and 90% of individuals on ART have durable viral suppression. For example, we are leading a major trial in South Africa and Zambia to evaluate the impact of a combination prevention intervention on new cases of HIV in the community. The intervention includes household-based HIV testing and linkage-to-health services by community care providers, and immediate initiation of treatment delivered through routine healthcare services.
TEG research on TB includes studies to evaluate improved TB treatment strategies, improved diagnosis, prevention and control of drug-resistant TB, improved TB case finding and prevention, and evaluation of structural interventions (social support and monetary incentives) to control TB. For example, we are working on a trial to evaluate an improved electronic medication device for TB patients to reduce treatment failure and subsequent recurrence/retreatment in the absence of directly observed treatment.
We will continue our long-standing work on intervention strategies for the control and elimination of NTDs, and our more recent involvement in the control of outbreaks such as the Ebola and Zika virus outbreaks. We will also continue our work on the effectiveness of lay-health worker interventions to treat common mental disorders (depression and anxiety), focusing particularly on treatment of these conditions among adolescents, in whom over half of mental health disorders start.
Through the MRC Programme Grant, we leverage additional funding for research projects and support salaries for around 30 statisticians and epidemiologists, based at LSHTM. The grant is critical to enable us to recruit and retain these scientists, who have disease and methodological expertise in the design and analysis of epidemiological studies in LMICs. We collaborate with the MRC Units in The Gambia and Uganda, and over 50 other research institutes in LMICs. We will continue our initiatives to increase capacity in medical statistics in sub-Saharan Africa, for example by expanding the MRC TEG Fellowship scheme, which to date has trained 17 medical statisticians through a Masters in Medical Statistics at LSHTM, followed by a placement year. All are now working as medical statisticians in Africa.
Technical Summary
The aim of TEG is to conduct cutting-edge epidemiological studies on health problems of low- and middle-income countries (LMICs). TEG will continue to have a major focus on the epidemiology and control of infectious diseases, with increased emphasis on evaluating delivery strategies for interventions of proven effectiveness. We will expand our research on emerging infectious diseases, adolescent health, non-communicable diseases and applied epidemiological methods. We will also expand our capacity building initiatives, including the TEG Fellowship scheme to train African statisticians. These issues are critical to the UK Government strategy for overseas aid, as indicated by the £1.5 billion Global Challenges Research Fund to support challenges in LMICs.
TEG malaria research includes assessing the scale-up and combination of malaria control tools, e.g. investigating sustainable and more effective deployment of long-lasting insecticidal nets, and effective combination therapies. For HIV, we focus on community-based approaches to improving HIV testing and linkage-to-care in sub-Saharan Africa, and interventions for key populations in high-incidence settings. Our TB research includes studies to evaluate improved TB treatment strategies, improved diagnosis, prevention and control of drug-resistant TB, improved case finding and prevention, and structural interventions. We will continue research on the control and elimination of NTDs, including the Ebola and Zika virus outbreaks. Finally, we conduct applied methodological work to advance the design and analysis of epidemiological studies in LMICs.
Through the Programme Grant, we will continue to leverage funding to recruit and retain a critical mass of scientists who have expertise in design and analysis of epidemiological studies in LMICs, and relevant disease-specific expertise. We collaborate closely with the African MRC Units and many other institutes in LMICs, with whom we published 700 papers in the past 5 year
TEG malaria research includes assessing the scale-up and combination of malaria control tools, e.g. investigating sustainable and more effective deployment of long-lasting insecticidal nets, and effective combination therapies. For HIV, we focus on community-based approaches to improving HIV testing and linkage-to-care in sub-Saharan Africa, and interventions for key populations in high-incidence settings. Our TB research includes studies to evaluate improved TB treatment strategies, improved diagnosis, prevention and control of drug-resistant TB, improved case finding and prevention, and structural interventions. We will continue research on the control and elimination of NTDs, including the Ebola and Zika virus outbreaks. Finally, we conduct applied methodological work to advance the design and analysis of epidemiological studies in LMICs.
Through the Programme Grant, we will continue to leverage funding to recruit and retain a critical mass of scientists who have expertise in design and analysis of epidemiological studies in LMICs, and relevant disease-specific expertise. We collaborate closely with the African MRC Units and many other institutes in LMICs, with whom we published 700 papers in the past 5 year
Planned Impact
Beneficiaries of our research include i) populations in low- and middle-income countries (LMICs) affected by the diseases which we research, ii) local and national stakeholders; iii) national and international policy makers; iv) scientists within TEG; v) our collaborators in LMICs; and vi) the wider academic community of global health researchers.
i) The diseases we focus on are malaria, HIV, TB, emerging and neglected diseases - including mental health, eye health and non-communicable diseases. Each of these disproportionately affect the poorest in resource-poor countries, and those marginalised from society. These diseases also have a substantial impact on national socio-economic development. By reducing the rates of important causes of ill health, we have the potential to alleviate poverty as well as improving life expectancy. Many of the studies we undertake involve community-based interventions focused on overcoming barriers to health service access and to minimize stigma and discrimination. This is a common issue for many of the diseases we work on, and particularly for HIV and mental health, and among some of the key populations that we focus on, including adolescents and high-risk groups.
ii) We engage with local and national stakeholders, as described in the Pathways to Impact statement, and they benefit directly, for example, from our studies to evaluate optimal strategies for delivery of interventions of known effectiveness (for example on integrating HIV and non-communicable disease treatment and care); or to improve efficiency or cost of interventions (for example the first trial of reduced dose human papillomavirus (HPV) vaccine in Tanzania, or the planned trial of fractional dose pneumococcal vaccine in Kenya).
iii) We are able to ensure that results from our research and other important studies help to inform new policies and guidelines, through our role on national and international advisory committees, including as Chair of the WHO Joint Technical Expert Group on Malaria Vaccines in Pivotal Phase 3 Trials & Beyond; and members of the UNAIDS Scientific Expert Panel, the scientific advisory committees of EDCTP and CEPI (Coalition for Epidemic Preparedness, Innovations), the WHO Technical Advisory Committee on Safe Male Circumcision, the WHO Evidence Review Group on Malaria in Pregnancy, the WHO Global Malaria Programme, Surveillance Monitoring and Evaluation Technical Advisory Group, and WHO Expert Working Groups on Lassa fever, Nipah virus and MERS Co-V vaccine Target Product Profiles.
iv) The Programme Grant enables us to sustain a strong critical mass of experienced statistical epidemiologists and to provide an actively supportive academic environment and mentorship for all our staff. We regularly review and encourage career development, support the development of Fellowship and research grant applications, and provide funds for training courses and conference attendance.
v) Our collaborators benefit directly from our research (see Letters of Support), as the Programme Grant enables us to provide consistent and continuous, disease-specific, statistical and epidemiological expertise that is in short supply in global health research. This leads to high-quality scientific outputs and new grant applications, which lead to population health benefits. We also have an impact on the careers of the MSc, PhD and post-doctoral students who we teach, supervise and mentor, both at LSHTM, through our Fellowship scheme and collaborative links, as described in the Case for Support and Academic Beneficiaries sections.
vi) We produce around 120 papers annually, and disseminate findings at international conferences in order to benefit to the wider academic community working on global health. This includes clinical epidemiologists, social scientists and laboratory scientists. In March 2021 we plan to hold a two-day symposium to increase the impact and reach of our research findings.
i) The diseases we focus on are malaria, HIV, TB, emerging and neglected diseases - including mental health, eye health and non-communicable diseases. Each of these disproportionately affect the poorest in resource-poor countries, and those marginalised from society. These diseases also have a substantial impact on national socio-economic development. By reducing the rates of important causes of ill health, we have the potential to alleviate poverty as well as improving life expectancy. Many of the studies we undertake involve community-based interventions focused on overcoming barriers to health service access and to minimize stigma and discrimination. This is a common issue for many of the diseases we work on, and particularly for HIV and mental health, and among some of the key populations that we focus on, including adolescents and high-risk groups.
ii) We engage with local and national stakeholders, as described in the Pathways to Impact statement, and they benefit directly, for example, from our studies to evaluate optimal strategies for delivery of interventions of known effectiveness (for example on integrating HIV and non-communicable disease treatment and care); or to improve efficiency or cost of interventions (for example the first trial of reduced dose human papillomavirus (HPV) vaccine in Tanzania, or the planned trial of fractional dose pneumococcal vaccine in Kenya).
iii) We are able to ensure that results from our research and other important studies help to inform new policies and guidelines, through our role on national and international advisory committees, including as Chair of the WHO Joint Technical Expert Group on Malaria Vaccines in Pivotal Phase 3 Trials & Beyond; and members of the UNAIDS Scientific Expert Panel, the scientific advisory committees of EDCTP and CEPI (Coalition for Epidemic Preparedness, Innovations), the WHO Technical Advisory Committee on Safe Male Circumcision, the WHO Evidence Review Group on Malaria in Pregnancy, the WHO Global Malaria Programme, Surveillance Monitoring and Evaluation Technical Advisory Group, and WHO Expert Working Groups on Lassa fever, Nipah virus and MERS Co-V vaccine Target Product Profiles.
iv) The Programme Grant enables us to sustain a strong critical mass of experienced statistical epidemiologists and to provide an actively supportive academic environment and mentorship for all our staff. We regularly review and encourage career development, support the development of Fellowship and research grant applications, and provide funds for training courses and conference attendance.
v) Our collaborators benefit directly from our research (see Letters of Support), as the Programme Grant enables us to provide consistent and continuous, disease-specific, statistical and epidemiological expertise that is in short supply in global health research. This leads to high-quality scientific outputs and new grant applications, which lead to population health benefits. We also have an impact on the careers of the MSc, PhD and post-doctoral students who we teach, supervise and mentor, both at LSHTM, through our Fellowship scheme and collaborative links, as described in the Case for Support and Academic Beneficiaries sections.
vi) We produce around 120 papers annually, and disseminate findings at international conferences in order to benefit to the wider academic community working on global health. This includes clinical epidemiologists, social scientists and laboratory scientists. In March 2021 we plan to hold a two-day symposium to increase the impact and reach of our research findings.
Organisations
- London Sch of Hygiene and Trop Medicine, United Kingdom (Lead Research Organisation)
- UNICEF, United States (Collaboration)
- National University of Kyiv Mohyla Academy (Collaboration)
- University of Tours (Collaboration)
- Ipsos-MORI (Collaboration)
- Christian Medical College Vellore (Collaboration)
- Aga Khan University (Collaboration)
- HealthRight International (Collaboration)
- University of Makeni (Collaboration)
- University of Lusaka (Collaboration)
- Medicines for Malaria Venture (MMV) (Collaboration)
- University of Ibadan, Nigeria (Collaboration)
- University of Malawi, Malawi (Collaboration)
- MRC/UVRI Uganda Research Unit on AIDS, Uganda (Collaboration)
- Leiden University Medical Center (Collaboration)
- Organization for Public Health Interventions and Development (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- National Institute for Medical Research (Collaboration)
- University of Ghana, Ghana (Collaboration)
- University of Bristol, United Kingdom (Collaboration)
- St George's University of London, United Kingdom (Collaboration)
- World Health Organization (WHO) (Collaboration)
- University of Birmingham, United Kingdom (Collaboration)
- University of Sao Paolo (Collaboration)
- Peekvsion (Collaboration)
- Ministry of Health, Uganda (Collaboration)
- Kenyan Institute for Medical Research (KEMRI) (Collaboration)
- Biomedical Research and Training Inst, Zimbabwe (Collaboration)
- Royal Veterinary College, United Kingdom (Collaboration)
- The SHM Foundation (Collaboration)
- Johns Hopkins University, United States (Collaboration)
Publications


Abaasa A
(2019)
Use of reliable contraceptives and its correlates among women participating in Simulated HIV vaccine efficacy trials in key-populations in Uganda.
in Scientific reports


Alexander N
(2020)
Spatial spillover analysis of a cluster-randomized trial against dengue vectors in Trujillo, Venezuela.
in PLoS neglected tropical diseases


Anywaine Z
(2019)
Safety and Immunogenicity of a 2-Dose Heterologous Vaccination Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Uganda and Tanzania.
in The Journal of infectious diseases

Arunga S
(2019)
Delay Along the Care Seeking Journey of Patients with Microbial Keratitis in Uganda.
in Ophthalmic epidemiology

Arunga S
(2019)
The impact of microbial keratitis on quality of life in Uganda.
in BMJ open ophthalmology

Arunga S
(2019)
Traditional eye medicine use in microbial keratitis in Uganda: a mixed methods study.
in Wellcome open research

Assefa A
(2019)
Multiplex serology demonstrate cumulative prevalence and spatial distribution of malaria in Ethiopia.
in Malaria journal
Title | STAMP film |
Description | An 8 minute film describing the STAMP trial. Clinical trial coordinators and research staff recruiting and following-up patients and laboratory staff, and the international trial coordinator were interviewed. |
Type Of Art | Film/Video/Animation |
Year Produced | 2018 |
Impact | Film shown at the Steve Lawn Memorial lecture, March 2018. Over 200 views https://www.youtube.com/watch?v=CoP5GIfiMe8&t=1s [full version] https://www.youtube.com/watch?v=LYHEFQsE7HE&t=12s [social media version] |
URL | https://www.youtube.com/watch?v=CoP5GIfiMe8&t=1s |
Description | Design of treatment trials for 2019-nCoV cases (PS, TE) |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Impact | Should identify more rapidly increases in survival and quality of life |
Description | PopART and policy for HIV testing and treatment |
Geographic Reach | Africa |
Policy Influence Type | Citation in other policy documents |
Impact | Trial findings have informed design and delivery of HIV testing services in S Africa and WHO deliberations on implementation of universal testing and treatment |
URL | http://hivst.org/policy/zambia |
Description | Prioritisation of 2019-nCoV vaccines (PS) |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Membership of a guideline committee |
Impact | Should identify more rapidly increases in survival and quality of life |
Description | STAMP - Article in Aidsmap following publication of CID paper |
Geographic Reach | Africa |
Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
URL | http://www.aidsmap.com/news/feb-2020/alarmingly-high-mortality-hospitalised-patients-hivtb-co-infect... |
Description | STAMP - TAG |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
URL | http://www.treatmentactiongroup.org/content/activists-call-countries-and-donors-immediately-scale-us... |
Guideline Title | The use of lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis and screening of active tuberculosis in people living with HIV |
Description | STAMP - preparatory work to trial cited in WHO 2019 LAM policy update |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Citation in clinical guidelines |
URL | https://www.who.int/tb/publications/use-of-lf-lam-tb-hiv/en/ |
Description | UK Government Period Poverty Taskforce |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
URL | https://www.gov.uk/government/news/period-poverty-taskforce-minister-announces-next-steps-on-menstru... |
Description | WHO Technical Consultation on Chemoprevention (MC) |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
Impact | May lead to more flexible recommendations on chemopreventive approaches allowing its use in a wider area and/or subsequent policy changes |
Description | WHO Technical Consultation on SMC (MC) |
Geographic Reach | Multiple continents/international |
Policy Influence Type | Participation in a advisory committee |
Impact | May lead to more flexible recommendations on SMC allowing its use in a wider area and/or subsequent policy changes |
Description | A pragmatic randomised study to optimise screening, prevention and care for tuberculosis in Malawi (PROSPeCT Study) |
Amount | £1,077,349 (GBP) |
Funding ID | 206575 |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2017 |
End | 08/2022 |
Description | Attractant Targeted Sugar Bates (ATSB) trial |
Amount | $6,499,963 (USD) |
Organisation | IVCC |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2018 |
End | 12/2020 |
Description | Combination prevention and strategies for HIV control: In-depth analysis of data from the HPTN 071 (PopART) trial |
Amount | $1,198,185 (USD) |
Organisation | Bill and Melinda Gates Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 02/2020 |
End | 01/2022 |
Description | Cross-sectional survey to measure additional outcomes for the HPTN 071 (PopART study) |
Amount | $700,000 (USD) |
Organisation | International Initiative for Impact Evaluation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2019 |
End | 10/2020 |
Description | Crowdsourcing with adolescents in Senegal |
Amount | £323,754 (GBP) |
Funding ID | MR/S023712/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2019 |
End | 08/2021 |
Description | Effects of metronidazole plus intermittent preventive treatment of malaria in pregnancy on birth outcomes: a randomised controlled trial in Zambia |
Amount | £2,545,958 (GBP) |
Funding ID | MR/S004998/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2018 |
End | 10/2022 |
Description | Insecticide treated eave nets and window screens for malaria control |
Amount | £212,405 (GBP) |
Funding ID | MR/T003677/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2020 |
End | 06/2021 |
Description | Male partner-assisted contact tracing for HIV and tuberculosis in Malawi: an adaptive multi-arm multi-stage randomised trial (mPATCH-TB) |
Amount | £112,515 (GBP) |
Funding ID | MR/R019762/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2018 |
End | 04/2020 |
Description | Operations research to measure the effectiveness of a peer-led mental health intervention on virological suppression and mental health among adolescents with HIV in Zimbabwe (ALHIV Adherence - Mental Health) |
Amount | $40,202 (USD) |
Organisation | AfricAid |
Sector | Charity/Non Profit |
Country | United States |
Start | 02/2019 |
End | 08/2020 |
Description | Perceptions, knowledge and use (and mis-use) of over the counter analgesics in East and Southern Africa |
Amount | £20,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 10/2019 |
End | 03/2020 |
Description | Randomised controlled trial of cipro vs standard of care in plague |
Amount | £1,588,565 (GBP) |
Funding ID | 216273/Z/19/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 11/2019 |
End | 04/2023 |
Description | Spatial Intelligence System for precision larviciding |
Amount | $796,731 (USD) |
Organisation | IVCC |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 01/2018 |
End | 09/2020 |
Description | TB MATE |
Amount | $73,273 (USD) |
Organisation | Bill and Melinda Gates Foundation |
Sector | Charity/Non Profit |
Country | United States |
Start | 06/2019 |
End | 11/2021 |
Description | The Bioko Island Malaria Elimination Project (BIMEP) |
Amount | £40,203 (GBP) |
Organisation | Medical Care Development |
Sector | Hospitals |
Country | United States |
Start | 01/2019 |
End | 12/2019 |
Description | The epidemiology of scrub typhus and rickettisial infections in a highly endemic rural setting in South India: Population-based Cohort Study. |
Amount | £767,928 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2020 |
End | 12/2022 |
Description | UK-Brazil Joint Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) |
Amount | £1,164,840 (GBP) |
Funding ID | MR/S019510/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2019 |
End | 03/2022 |
Description | Zvatinoda! (What we want!): Increasing demand and uptake of sexual and reproductive health services by young people in Zimbabwe |
Amount | £151,520 (GBP) |
Funding ID | MR/T003200/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2019 |
End | 02/2021 |
Title | Developing tools for population estimation methods (CG) |
Description | Developing tools for population estimation methods |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | Tool available and used for estimating populations cheaply and rapidly. Used by MITU on other research projects. Also used by Lake Victoria Consortium. Method feeding into to other research around population estimation and currently in discussions with Gates Foundation for use in EPI and other vaccine work. |
Description | CADDE (UK-Brazil Joint Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology) |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Study design and analysis, training |
Collaborator Contribution | Genetics, public health, virology |
Impact | Next Generation Sequencing workshop held in Sao Paulo, December 2019. Multidisciplinary: Genetics, public health, virology |
Start Year | 2018 |
Description | CADDE (UK-Brazil Joint Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology) |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Study design and analysis, training |
Collaborator Contribution | Genetics, public health, virology |
Impact | Next Generation Sequencing workshop held in Sao Paulo, December 2019. Multidisciplinary: Genetics, public health, virology |
Start Year | 2018 |
Description | CADDE (UK-Brazil Joint Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology) |
Organisation | University of Sao Paulo |
Country | Brazil |
Sector | Academic/University |
PI Contribution | Study design and analysis, training |
Collaborator Contribution | Genetics, public health, virology |
Impact | Next Generation Sequencing workshop held in Sao Paulo, December 2019. Multidisciplinary: Genetics, public health, virology |
Start Year | 2018 |
Description | CHANGE |
Organisation | HealthRight International |
Country | United States |
Sector | Hospitals |
PI Contribution | Study design, analysis |
Collaborator Contribution | Study design, implementation and evaluation |
Impact | Multidisciplinary: alcohol use disorders, humanitarian health, clinical trials |
Start Year | 2020 |
Description | CHANGE |
Organisation | Johns Hopkins University |
Country | United States |
Sector | Academic/University |
PI Contribution | Study design, analysis |
Collaborator Contribution | Study design, implementation and evaluation |
Impact | Multidisciplinary: alcohol use disorders, humanitarian health, clinical trials |
Start Year | 2020 |
Description | CHANGE |
Organisation | National University of Kyiv Mohyla Academy |
Country | Ukraine |
Sector | Academic/University |
PI Contribution | Study design, analysis |
Collaborator Contribution | Study design, implementation and evaluation |
Impact | Multidisciplinary: alcohol use disorders, humanitarian health, clinical trials |
Start Year | 2020 |
Description | CHI-S (E.Webb) |
Organisation | Leiden University Medical Center |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | Study design, trial statistician |
Collaborator Contribution | Study design; coordination; field activities; lab studies |
Impact | None yet, papers in preparation. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
Start Year | 2020 |
Description | CHI-S (E.Webb) |
Organisation | MRC/UVRI Uganda Research Unit on AIDS |
Country | Uganda |
Sector | Public |
PI Contribution | Study design, trial statistician |
Collaborator Contribution | Study design; coordination; field activities; lab studies |
Impact | None yet, papers in preparation. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
Start Year | 2020 |
Description | CHI-S (E.Webb) |
Organisation | Ministry of Health, Uganda |
Country | Uganda |
Sector | Public |
PI Contribution | Study design, trial statistician |
Collaborator Contribution | Study design; coordination; field activities; lab studies |
Impact | None yet, papers in preparation. Multidisciplinary: epidemiology, public health, statistics, clinical trials |
Start Year | 2020 |
Description | Lurkana HIV paediatric outbreak |
Organisation | Aga Khan University |
Country | Pakistan |
Sector | Academic/University |
PI Contribution | study statistician |
Collaborator Contribution | fieldwork, study coordination, knowledge of setting, clinical input, political engagement |
Impact | two publications, main results paper in progress. Multidisciplinary: epidemiology, molecular epidemiology |
Start Year | 2019 |
Description | MERS-CoV in Jordan |
Organisation | Royal Veterinary College (RVC) |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Design of study and analysis of results |
Collaborator Contribution | Fieldwork in, and knowledge of, Jordan and knowledge of camels and camel infections |
Impact | None yet, two papers in preparation. Discipline: vet epidemiology |
Start Year | 2016 |
Description | Oleylphosphocholine for the treatment of Old World Cutaneous Leishmaniasis(TT4CL) |
Organisation | St George's University of London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Design of study and analysis of results |
Collaborator Contribution | Clinical field and lab studies. |
Impact | None yet. Multidisciplinary: epidemiology, clinical trials, immunology |
Start Year | 2019 |
Description | Peek |
Organisation | Peekvsion |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Study design, analysis |
Collaborator Contribution | Technology, programme delivery |
Impact | Multidisciplinary: statistics, clinical trials |
Start Year | 2020 |
Description | Plague in Madagascar |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | trial statistician |
Collaborator Contribution | design and coordination of the study |
Impact | None yet. Multidisciplinary: statistics, clinical trials |
Start Year | 2019 |
Description | Population estimation methods for PNG |
Organisation | Medicines for Malaria Venture (MMV) |
Country | Switzerland |
Sector | Charity/Non Profit |
PI Contribution | Design and analsysis of population estimation |
Collaborator Contribution | Fieldwork, study coordination, provision of imagery |
Impact | none yet. Multidisciplinary: Epidemiology, GIS, data science |
Start Year | 2019 |
Description | Recruitment in stepped wedge trials |
Organisation | François Rabelais University or University of Tours |
Country | France |
Sector | Academic/University |
PI Contribution | Statistical support |
Collaborator Contribution | study design and analysis |
Impact | None yet. Multidisciplinary: statistics, clinical trials |
Start Year | 2019 |
Description | Risk of bias in cluster randomized trials |
Organisation | University of Birmingham |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | PhD student supervision and statistical support |
Collaborator Contribution | Design and analysis, and supervision |
Impact | None yet. Multidisciplinary: statistics, clinical trials |
Start Year | 2019 |
Description | SUCCEED |
Organisation | University of Ibadan |
Country | Nigeria |
Sector | Academic/University |
PI Contribution | Study design |
Collaborator Contribution | Design, implementation, analysis, interpret |
Impact | Multidisciplinary: Disability, epidemiology, mental health, clinical trials |
Start Year | 2020 |
Description | SUCCEED |
Organisation | University of Makeni |
Country | Sierra Leone |
Sector | Academic/University |
PI Contribution | Study design |
Collaborator Contribution | Design, implementation, analysis, interpret |
Impact | Multidisciplinary: Disability, epidemiology, mental health, clinical trials |
Start Year | 2020 |
Description | SUCCEED |
Organisation | University of Malawi |
Country | Malawi |
Sector | Academic/University |
PI Contribution | Study design |
Collaborator Contribution | Design, implementation, analysis, interpret |
Impact | Multidisciplinary: Disability, epidemiology, mental health, clinical trials |
Start Year | 2020 |
Description | Scrub typhus India |
Organisation | Christian Medical College, Vellore |
Country | India |
Sector | Academic/University |
PI Contribution | Design of study and analysis of results |
Collaborator Contribution | Epidemiology, ecology, one health |
Impact | https://onlinelibrary.wiley.com/doi/abs/10.1111/tmi.13322 Multidisciplinary: epidemiology, clinical science, entomology, statistics, diagnostic assays |
Start Year | 2018 |
Description | Social and behavioral norms related to social protection |
Organisation | Ipsos MORI |
Country | United Kingdom |
Sector | Private |
PI Contribution | Statistical support for sample design and analysis |
Collaborator Contribution | Ipsos coordinating data collection ; UNICEF funding |
Impact | Surveys from 7 countries measuring social norms, publications. Multi-disciplinary: epidemiology, public health, qualitative/anthropology |
Start Year | 2020 |
Description | Social and behavioral norms related to social protection |
Organisation | UNICEF |
Country | United States |
Sector | Public |
PI Contribution | Statistical support for sample design and analysis |
Collaborator Contribution | Ipsos coordinating data collection ; UNICEF funding |
Impact | Surveys from 7 countries measuring social norms, publications. Multi-disciplinary: epidemiology, public health, qualitative/anthropology |
Start Year | 2020 |
Description | Using pneumococcal carriage and invasiveness to inform vaccine policy in tropical Africa (CB) |
Organisation | Kenyan Institute for Medical Research (KEMRI) |
Country | Kenya |
Sector | Public |
PI Contribution | study statistician |
Collaborator Contribution | design and coordination of the study |
Impact | no papers yet. Multi-disciplinary: epidemiology, genetics, statistics |
Start Year | 2019 |
Description | VITALITY |
Organisation | Biomedical Research and Training Institute (BRTI) |
Country | Zimbabwe |
Sector | Charity/Non Profit |
PI Contribution | Study design, analysis |
Collaborator Contribution | Study design, implementation and evaluation |
Impact | Multidisciplinary: clinical medicine, epidemiology, clinical trials, health economics |
Start Year | 2020 |
Description | VITALITY |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Study design, analysis |
Collaborator Contribution | Study design, implementation and evaluation |
Impact | Multidisciplinary: clinical medicine, epidemiology, clinical trials, health economics |
Start Year | 2020 |
Description | VITALITY |
Organisation | University of Lusaka |
Country | Zambia |
Sector | Academic/University |
PI Contribution | Study design, analysis |
Collaborator Contribution | Study design, implementation and evaluation |
Impact | Multidisciplinary: clinical medicine, epidemiology, clinical trials, health economics |
Start Year | 2020 |
Description | VITALITY |
Organisation | University of Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Study design, analysis |
Collaborator Contribution | Study design, implementation and evaluation |
Impact | Multidisciplinary: clinical medicine, epidemiology, clinical trials, health economics |
Start Year | 2020 |
Description | Y-CHECK |
Organisation | National Institute for Medical Research, Tanzania |
Department | Mwanza Intervention Trials Unit (MITU) |
Country | Tanzania, United Republic of |
Sector | Public |
PI Contribution | Study design |
Collaborator Contribution | Study design, implementation |
Impact | Multidisciplinary: epidemiology, public health |
Start Year | 2018 |
Description | Y-CHECK |
Organisation | University of Ghana |
Country | Ghana |
Sector | Academic/University |
PI Contribution | Study design |
Collaborator Contribution | Study design, implementation |
Impact | Multidisciplinary: epidemiology, public health |
Start Year | 2018 |
Description | Y-CHECK |
Organisation | World Health Organization (WHO) |
Country | Global |
Sector | Public |
PI Contribution | Study design |
Collaborator Contribution | Study design, implementation |
Impact | Multidisciplinary: epidemiology, public health |
Start Year | 2018 |
Description | Zvatinoda! |
Organisation | Organization for Public Health Interventions and Development |
Country | Zimbabwe |
Sector | Charity/Non Profit |
PI Contribution | Study design, project coordination |
Collaborator Contribution | Study design and coordination, fieldwork, liaison with policy makers, digital intervention expertise |
Impact | none yet. Multidisciplinary: Epidemiology, social science, implementation science |
Start Year | 2019 |
Description | Zvatinoda! |
Organisation | The SHM Foundation |
Country | United Kingdom |
Sector | Charity/Non Profit |
PI Contribution | Study design, project coordination |
Collaborator Contribution | Study design and coordination, fieldwork, liaison with policy makers, digital intervention expertise |
Impact | none yet. Multidisciplinary: Epidemiology, social science, implementation science |
Start Year | 2019 |
Description | 5th Southern Africa Malaria Research Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation presenting results of CRT on reactive focal malaria elimination interventions in Namibia |
Year(s) Of Engagement Activity | 2019 |
Description | AMR STI Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 2 day conference tp bring together experts working at the interface of AMR and STI research, policy and practice with a view to identifying bottlenecks and solutions for tackling STI AMR and developing short and long term action plans |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.lshtm.ac.uk/newsevents/events/global-local-addressing-threat-amr-sti-control |
Description | ASTMH conference (JB) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation at ASTMH conference |
Year(s) Of Engagement Activity | 2019 |
Description | ASTMH: Symposium on PBO Nets |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Symposium on New Generation Long Lasting Insecticide Treated Nets for malaria prevention |
Year(s) Of Engagement Activity | 2019 |
Description | Adolescent Health 2019 Coming of Age |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Helen Weiss, oral presentation at Adolescent Health - Coming of age conference held by RCPCH |
Year(s) Of Engagement Activity | 2019 |
Description | BBC world service interview |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | BBC World Service interview in response to second recorded case of "cure" from HIV announced at CROI |
Year(s) Of Engagement Activity | 2019 |
Description | CROI/ ISSTDR/ IAS 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talks on PopART trial results at CROI, IAS and ISSTDR conferences in 2019 |
Year(s) Of Engagement Activity | 2019 |
Description | Ending Period Poverty Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Workshop on ending period poverty by 2030, bringing together researchers, funders, policy makers and practitioners to discuss how to use evidence to develop and deliver menstrual health policies and programmes. |
Year(s) Of Engagement Activity | 2017,2019 |
Description | Feminem Podcast |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Podcast on careers in epidemiology and gender equity in leadership |
Year(s) Of Engagement Activity | 2019 |
Description | HAYA Adolescent health research dissemination |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Following the HAYA research programmed in KwaZulu-Natal, South Africa. Young people co-created and performed songs and films to share messages from the research with their peers and other stakeholders. |
Year(s) Of Engagement Activity | 2019 |
Description | IAS 2018 (KS) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Evaluating uptake of anti-retroviral treatment irrespective of CD4 count |
Year(s) Of Engagement Activity | 2018 |
Description | Imperial University invited talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Invited seminar to promote good trial methodology |
Year(s) Of Engagement Activity | 2019 |
Description | Joint WHO-Wageningen University of Research Global Vector Control Response conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Oral Presentation on Insecticides and Malaria Control |
Year(s) Of Engagement Activity | 2019 |
Description | King College invited seminar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Invited seminar to promote good trial methodology |
Year(s) Of Engagement Activity | 2019 |
Description | Media interviews around release of primary results of PopART trial |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Media interviews around the publication of the primary results of the PopART trial |
Year(s) Of Engagement Activity | 2019 |
Description | Mental Health World Congress News |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Interview in Mental Health World Congress Magazine about menstrual health research in the context of school mental health and school drop out |
Year(s) Of Engagement Activity | 2019 |
Description | Networking Breakfast |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | TEG networking breakfast at LSHTM - approx 20 LSHTM staff attended a talk designed to promote TEG's work and encourage new collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Pint of Science (SN) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Public talk about trial in Uganda and South Africa, as part of national science festival |
Year(s) Of Engagement Activity | 2019 |
Description | PopART and UTT |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talk at Francis Crick Institute for World AIDS Day 2019 |
Year(s) Of Engagement Activity | 2019 |
Description | STI Vaccine Workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Workshop on the need for STI vaccines/bottlenecks for development & implementation, bringing together researchers, policy makers and clinicians |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.lshtm.ac.uk/newsevents/events/sti-vaccine-workshop-innovations-impact |
Description | SUSAN-SSACAB conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Six previous TEG fellows attended, presented abstracts & discussed to strengthen the network, to share expertise, collaborate on common projects. Also contributed to discussions on how TEG can contribute to the SSACAB initiative for capacity building in SSA |
Year(s) Of Engagement Activity | 2019 |
Description | Talks on PopART trial results |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Talks on PopART trial results given at University of Third Age, Francis Crick Institute and other organizations |
Year(s) Of Engagement Activity | 2019 |
Description | The Behaviour Insights Team stepped wedge trial talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Invited seminar at a social purpose company part owned by the cabinet office to promote good trial methodology |
Year(s) Of Engagement Activity | 2019 |
Description | Young Scientists (SN) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Around 12-20 local school pupils (age 14-18) attend LSHTM for 1-2 weeks. They design and carry out a piece of scientific research, supported by academic staff and postgraduate student mentors. They then present their results to an open seminar. Held three times per year. |
Year(s) Of Engagement Activity | 2019 |