Quality and Safety in Organ Donation Tissue Bank - Expansion to include Pancreas/Islets, Heart and Lungs

Lead Research Organisation: University of Oxford
Department Name: Surgical Sciences

Abstract

Organ transplantation saves thousands of lives every year and is the treatment of choice for end stage organ failure. Despite awareness of importance of transplantation, a gulf remains between the supply and need for life-saving organs. This is predicted to worsen over the next decade, making this disparity a key challenge facing the transplant community today. Due to this shortage, nowadays older and higher risk donors are accepted. However, uncertainty as regards transplantability often results in decline and sometimes discard of scarce organs. Between April 2015 and March 2016, 479 patients died waiting for a lifesaving transplant. A further 3,452 patients were temporarily suspended from the waiting list because they were unfit for transplant.
The Quality in Organ Donation (QUOD) Biobank was established in 2012. This unique resource combines collection of detailed clinical information from virtually all organ donors in the UK with blood and urine samples taken around the time of donation and carefully collected small biopsies from a range of organs stored within a central 'bank'. This has been invaluable in research focused on understanding how stress associated with becoming an organ donor around the time of death affects control of important whole body systems such as blood pressure and glucose levels in addition to impact on specific organs. This has already enabled otherwise impossible research focused on better selection and optimisation of organs enhancing successful transplantation.
The pancreas, heart and lungs work in concert to maintain glucose levels, blood pressure and effective oxygenation throughout life. The extreme stress around the time of death has a major impact on these control systems. Despite a huge unmet clinical need, 'conversion' of these organs into successful transplants is much lower than in kidney transplantation. Impairment and failure of these organs is also central to many of the most common and challenging chronic diseases, including diabetes, heart failure; and lung disease.
We propose to expand QUOD to include samples from pancreas, heart and lungs and will work closely with MRC Units to ensure provision to the research community of highest quality state-of-the-art clinical pathology and molecular techniques as well as single cell analysis platforms, in addition to facilities expert in processing organs to retrieve live functioning cells. This will allow us to create detailed atlases and a data library representing the range of normal, acutely stressed and chronically diseased tissues from these organs that can be seldom accessed in life which has severely limited true understanding of mechanisms driving damage and failure. This type of resource linked to such high quality clinical information and a library of new markers associated with these processes and easily monitored from blood samples does not currently exist.
The QUOD remit and proposed expansion will be made accessible to the widest possible scientific and clinical community. It will enable new understanding of causes of organ stress, facilitating new treatments to maximise transplant success and ultimately help to prevent / reverse chronic diseases without need for transplantation. In type 1 and 2 diabetes it is becoming clear that insulin-producing cells are not completely destroyed, offering exciting new possibilities for reactivating function which may ultimately lead to a cure for this burdensome and dangerous disease. Deeper understanding of mechanisms underlying heart pump failure will facilitate increased numbers of heart transplants but also new treatments for all with chronic heart failure targeting specific processes damaging the muscle. Elucidation of the causes of scarring lung disease will be accelerated through this resource. Moreover, previously impossible parallel research exploring pathological interplay between pancreas, heart and lungs with already collected data on liver and kidney will be enabled.

Technical Summary

The QUOD Biobank established in 2012 and funded by NHSBT until 2020, provides a unique, rapidly expanding resource comprising rich clinical data of most UK deceased organ donors; banked peri-donation blood and urine samples underpinning an 'omics' biomarker exploration / bioinformatics core; and a central tissue bank, currently including liver, kidney, ureter, and spleen biopsies from 85% of donors.
A special multi-centre HTA site licence comprising 62 hospitals across the UK has been awarded to NHSBT enabling specimen removal during donation for research banking. A robust and sustainable infrastructure has been established. A bespoke 'QUOD box' is used at the donor hospital to contain all samples including blood, urine, and tissue biopsies. Bloods are collected in specific tubes to fulfil individual requirements. Tissue biopsies are preserved in buffered formalin to be processed into formalin fixed paraffin embedded (FFPE) tissue blocks for histological sectioning and analysis. Additional biopsies are collected in RNAlater and snap-frozen for banking to enable metabolic, proteomic and DNA studies.
We propose expansion of sampling protocols to include collection of minimally invasive pancreas, heart and lung tissue biopsies as well as bronchioalveolar lavage samples. In addition, selected untransplanted pancreata, hearts, and lungs representing the breadth of normal, acutely stressed and chronically diseased clinical phenotypes will be transported to processing centres in Newcastle / Oxford for systematic biopsy collection, in depth phenotypic characterisation and structured pathology reporting to create searchable atlases and quantitative analyses linked to clinical data and serum proteomic biomarker library. Blocks for FFPE, frozen sectioning and EM will be stored and available for further analysis including tissue microarray, RNAScope, single cell sequencing. Live cells including intact pancreatic islets will be isolated for functional / single cell analysis.

Planned Impact

QUOD currently focuses on kidney and liver research, collecting blood, urine and tissue samples at several time points during donation to identify mechanisms of injury/repair in organ donors affecting outcomes after transplantation. QUOD includes a robust linked integration with data in the UK donor/transplant base, hosted by NHSBT, and one of the best of its kind. Cerebral injury with donation after brain death (DBD) or after circulatory death (DCD) accompanied by warm ischaemia results in complex pathways causing hypoxia and cellular stress followed by extreme systemic changes and a pro-inflammatory and pro-coagulatory state. This increases susceptibility for organ damage, aggravated by organ preservation and transplantation, increasing the chance of graft failure.

With a persistent gap between organ supply and clinical need, centres nowadays accept older and higher risk donor organs. The challenge is to successfully transplant these organs without further compromising outcomes. Exploring mechanisms behind ischaemia/reperfusion injury, identifying biomarkers to predict graft survival, and enhancing donor management are necessary. As mechanisms involved (cellular stress, hypoxia, hypoperfusion, hyperglycaemia) are clinically important and also of interest beyond pure transplant research, the expanded QUOD biobank will help a wider community, supported by applications funded by disease-specific charities. Expansion to all donor organs will significantly increase the research potential, attracting new scientific platforms. Through this application, we will add a national collection to QUOD of pancreas, heart and lung samples currently unavailable to the research community.
Using the existing QUOD infrastructure, pancreatic biopsies will be obtained from up to 500 organs per year retrieved for potential solid organ or islet transplantation and additional tubes added to the QUOD box. Pancreata which are not transplanted (from donors with/without pre-existing / stress-induced hyperglycaemia) will be transported to islet isolation facilities in Oxford and Newcastle for macroscopic assessment, multiple biopsy and islet isolation.

Similarly, cardiac biopsies will be obtained from up to 400 transplanted organs per year, with a similar number taken from non-used hearts. Bronchioloalveolar Lavage samples and tissue biopsies for lungs will be taken from up to 400 lung donors per year, including tissue specimens from those not retrieved for transplant.
The biobank links to the extensive NHSBT data repository for donor and recipient clinical data aligning with the MRC's strategic goal to deliver discoveries from data to improve public health. The translational research resulting from the proposed collection has the potential to reduce healthcare costs as outlined in the MRC's future vision. An increased pool of suitable donor organs can significantly reduce the number of patients relying on intensive care treatment due to organ failure. Intensive study on impact of organ donation on tissue function will facilitate development and optimisation of non-transplant therapeutics potentially transforming outcomes within the healthcare system for chronic diseases currently imposing a huge financial and human burden.

The proposed widened remit of QUOD will provide an invaluable resource for UK academic centres, registered with UKCRC, externally accessible and searchable through integration of the QUOD database with the Achiever Tissue Sample Tracking system established in collaboration with the Newcastle Molecular Pathology Node. Informed by the pathology atlas created from representative slides from each stored tissue block, further serial sections will be provided for research projects and linked to the 'omics' library in Oxford as well as clinical data base hosted by NHSBT. The research outputs will lead to the generation of new hypotheses and targets feeding further translational experimental research, a core goal.

Publications

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Guzzi F (2020) A systematic review to identify whether perfusate biomarkers produced during hypothermic machine perfusion can predict graft outcomes in kidney transplantation. in Transplant international : official journal of the European Society for Organ Transplantation

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Lerink LJS (2022) Preclinical models versus clinical renal ischemia reperfusion injury: A systematic review based on metabolic signatures. in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

 
Description Prof. James Shaw joins the Science and Research Advisory Group at Diabetes UK
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Whole organs for research
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
Impact Ultimately, the QUOD expansion aims to further the overall QUOD mission: saving lives and cutting health care costs by increasing the pool of transplantable organs, thereby addressing the growing gap between supply and demand in organ transplantation.
 
Description A cell atlas of the human outflow tract of the heart
Amount £458,113 (GBP)
Funding ID MR/S03613X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2019 
End 01/2021
 
Description A cell atlas of the human outflow tract of the heart (Joint-funding with MRC of the human cell atlas (HCA) work targeted at cardiovascular tissue)
Amount £275,905 (GBP)
Funding ID SP/18/12/34300 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2019 
End 02/2021
 
Description Assessing Donor kidneys and MonitorIng transplant REcipients (ADMIRE)
Amount £237,548 (GBP)
Organisation Kidney Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2021 
End 08/2024
 
Description COVID BioArchive
Amount £413,000 (GBP)
Organisation NHS Blood and Transplant (NHSBT) 
Sector Public
Country United Kingdom
Start 03/2020 
End 03/2025
 
Description DEMISTIFI
Amount £2,808,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2021 
End 07/2025
 
Description Great expectations: Building a shared understanding of the role of lay co-applicants in biomedical research
Amount £3,000 (GBP)
Organisation Newcastle University 
Sector Academic/University
Country United Kingdom
Start 01/2021 
End 12/2021
 
Description Industrial Transformation Training Centre for Cell and Tissue Engineering Technologies
Amount £2,700,000 (GBP)
Organisation Australian Research Council 
Sector Public
Country Australia
Start 11/2020 
End 10/2025
 
Description Organ Donation and Transplantation
Amount £1,150,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2020 
End 03/2022
 
Description Senescence as a potential therapeutic target for ischaemia reperfusion injury following acute myocardial infarction
Amount £270,312 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2019 
End 08/2021
 
Description Spatially resolved cellular and molecular drivers of cardiac remodeling in healthy and failing human hearts (joint funding with DZHK)
Amount £864,825 (GBP)
Funding ID SP/19/1/34461 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2019 
End 07/2022
 
Description UKRI Covid Allocation Funding
Amount £34,978 (GBP)
Organisation United Kingdom Research and Innovation 
Sector Public
Country United Kingdom
Start 11/2020 
End 09/2021
 
Description UKRMP/Immunology: Defining the role of tissue-resident immune cells in alveolar epithelial cell regeneration
Amount £886,110 (GBP)
Funding ID MR/S020918/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 02/2022
 
Description University of Oxford Public Engagement with Research Seed Fund
Amount £3,000 (GBP)
Organisation University of Oxford 
Sector Academic/University
Country United Kingdom
Start 12/2020 
End 06/2021
 
Title Collection Initiated for Cardiac and BAL samples 
Description QUOD successfully initiated collection of bronchoalveolar lavage (BAL) samples as well as cardiac samples from untransplanted hearts in February 2019. This involved a redesign of our sample collection boxes and the development of detailed training materials for the retrieval teams to collect these resources. These samples will be stored in our biobank facilities and accessible to researchers via the same application process as our established samples (kidney, liver, spleen, bloods, etc.), with the same links to clinical data via the NHSBT transplant database. 
Type Of Material Biological samples 
Year Produced 2019 
Provided To Others? Yes  
Impact No impact thus far, but we already have multiple applications in for the use of the cardiac samples. As soon as we collect enough of the right kinds of samples, we will distribute them to these researchers, who will then report back to QUOD on their findings as part of our application procedure. 
 
Title Collection initiated for pancreatic samples 
Description While we await regulatory clearance to begin receiving whole organs nationally on QUOD's ethics and licensing, the Newcastle team has been collecting and processing whole pancreases under their local research license. To date they have collected and processed over three dozen pancreata for the atlas, including several with Type I diabetes. Once the processing is complete, the remaining pancreatic tissue is being stored for inclusion in and transfer to the QUOD biobank based in Oxford. We are now able to accept pancreas' under QUOD-X. 
Type Of Material Biological samples 
Year Produced 2019 
Provided To Others? Yes  
Impact No impact yet, but once fully integrated the pancreatic samples, in combination with QUOD's link to the national transplant database, will open another valuable avenue of research into transplant outcomes. 
 
Title Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas 
Description The pancreas is particularly sensitive to acute cellular stress, but this has been difficult to evaluate using light microscopy. Pancreatic ischaemia associated with deceased organ donation negatively impacts whole-organ and isolated-islet transplantation outcomes. Post-mortem changes have also hampered accurate interpretation of ante-mortem pancreatic pathology. We have developed and validated a novel EM score providing standardised quantitative assessment of subcellular ultrastructural morphology in pancreatic acinar cells. This provides a robust novel tool for gold standard measurement of acute cellular stress in studies evaluating surrogate measures of peri-transplant ischaemia, organ preservation technologies and in samples obtained for detailed pathological examination of underlying pancreatic pathology. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2020 
Provided To Others? Yes  
Impact No impact yet. 
URL https://onlinelibrary.wiley.com/doi/10.1002/cjp2.185
 
Title Increasing the Number of Organs Available for Research (INOAR) 
Description Until recently, only organs removed for transplant, but subsequently not transplanted were available to researchers. Thanks to a collaboration between QUOD and Newcastle University, in partnership with NHS Blood and Transplant, new arrangements have been implemented that will allow hearts, lungs and pancreases which are unsuitable for transplantation to be retrieved for research purposes. This will greatly facilitate ongoing research into developing ways more donated organs can be converted into successful life-saving transplants. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact More organs have been made available for research that would have otherwise been discarded. 
 
Title Is Seeing Believing? AI Image Analysis to Assess Donor Pancreas Organ Quality 
Description P Ezuma, L Bates, E Thompson, C Wilson*, WE Scott III*: "Is Seeing Believing? AI Image Analysis to Assess Donor Pancreas Organ Quality." Oral Presentation at The British Transplantation Society Annual Congress 2020, Belfast, UK, 4-6, March, 2020. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2020 
Provided To Others? Yes  
Impact No impact yet. 
 
Title Online data variable dictionary 
Description A key project this year for the QUOD Data Assistant funded by the MRC grant was to develop a "data variable dictionary." This dictionary, posted online at the QUOD website, would make transparent to all researchers the hundreds of "standard" variables available to QUOD through its link with the National Transplant Database. This will facilitate and perhaps even stimulate their understanding of exactly what kinds of research questions may be answered via QUOD resources. The dictionary has been drafted and is awaiting final approval by NHSBT, and we hope to post no later than June 2019. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact This dictionary will streamline QUOD internal operations (as it will mean less staff time spent answering inquiries as to what data is available). It will also streamline applicant experience, as they no longer need to query QUOD directly about the range of data they can access. NHSBT has also signalled their interest in using this data dictionary more widely, for non-QUOD related research, and we are glad to thus contribute to the wider research ecosystem. 
 
Title QUOD Bespoke Sample Collection Program 
Description QUOD-X's sample collection programme allows researchers to request bespoke samples. Multiple researchers can request specific parts or samples of a single organ in addition to the standard QUOD sample set. The QUOD team arranges the allocation between projects. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact Since a single organ is shared between research teams, valuable tissue is not discarded. 
 
Title QUOD-Expand Organ Atlas 
Description QUOD-X's online pathology 'Organ Atlases' and a searchable library of multi-omics heart, lung, pancreas, kidney and liver data representing the breadth of normal, acutely stressed and chronically diseased clinical phenotypes. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact The current QUOD-Expand project objective was to launch this atlas, so we have yet to record any notable impact. 
 
Title Structured pancreas pathology reports 
Description A core goal of the QUOD pancreas pathology atlas will be to determine the range of phenotypic normality in the human pancreas. To that end, our pathologists have developed their structured pathology report for scoring the pancreases collected for the atlas project. The first five pancreases have been scored as a trial and pending validation, scoring will be conducted on the rest. We are also in opening discussions with an Oxford lab to incorporate AI-based digital pathology scoring into this project. The reports will be incorporated into the pathology atlas and made available to all researchers with access to that atlas. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2019 
Provided To Others? Yes  
Impact None yet. 
 
Title Whole Organ Acceptance and Allocation Infrastructure 
Description To accept whole organs for research, QUOD developed a robust infrastructure to cover acceptance, allocation, and transportation arrangements. Previously, researchers using whole organs would have had to generate this per-project. Coverage gaps have been extensive and consequently, too many organs have not been claimed for research, as they have been available out-of-hours. We have implemented a 24-7 on-call structure, using a technological solution to forward notifications from the ODT Hub and detailing instructions for on-call technicians in how to walk through the acceptance of organs. The Transplant Technicians also arrange for the organs to be delivered to the research institution through IMT Medical Transport, a contract ensures that delivery costs are capped. We currently accept whole hearts, pancreas' and lungs in Oxford and Newcastle. We have begun to make this infrastructure available to research groups throughout the country for a nominal service fee to ensure sustainability, which will resolve a key hurdle in facilitating this research nationwide. Our team in Oxford is currently testing this model with two groups to accept whole kidneys, and are circulating the information on the service to other research groups who may be interested in the service. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact We have only just made the service available, so we have not yet been able to see the impact. 
 
Title Achiever development for pancreas atlas 
Description The Newcastle team has implemented the use of Achiever LIMS to facilitate the tracking, auditing, and storage of samples involved in the organ atlas projects. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact Direct access to Achiever will not be made public, but the data contained within will be a core foundation for the publicly accessible organ atlases. 
 
Title NPESS raw data.xlsx 
Description Raw data for manuscript 'Development and application of a semi-quantitative scoring method for ultrastructural assessment of acute stress in pancreatic islets' 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact No impact to report. 
URL https://data.ncl.ac.uk/articles/dataset/NPESS_raw_data_xlsx/16955437
 
Title NPESS raw data.xlsx 
Description Raw data for manuscript 'Development and application of a semi-quantitative scoring method for ultrastructural assessment of acute stress in pancreatic islets' 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact No impact to report. 
URL https://data.ncl.ac.uk/articles/dataset/NPESS_raw_data_xlsx/16955437/1
 
Title Pancreas pathology scores 
Description A key outcome for the MRC-funded QUOD expansion will be the establishment of the range of normality within human pancreas tissue. To that end, our pathologists have developed a structured semi-quantitative pathology report. This has been deployed on five pancreases initially, with the rest to follow once the scores have been validated. The scores themselves are now thus the core of a valuable dataset which will be incorporated into the fully-built pathology atlas. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact No impact yet, but impact will be clear once more pancreata are scored and the dataset are available live on the pathology atlas. 
 
Title Whole Organ Allocation Tool 
Description Multiple centres have begun accepting organs for the QUOD Expand project, and that QUOD will ultimately be able to serve other research groups through whole organ provision. To that end we have developed an allocation tool, using parameters that our current researchers have provided, which can guide the on-call technicians in whether to accept an offered organ, where to send it, and how to get it there. This was an essential piece in the plan to develop 24-7 ability to accept organs. 
Type Of Material Data handling & control 
Year Produced 2020 
Provided To Others? No  
Impact The QUOD-Expand team has started accepting hearts, lungs and pancreas for researchers in Oxford and Newcastle and will start accepting kidneys in a matter of weeks for a research team in Nottingham. More organs are able to be accepted for researchers who may be preoccupied when an organ becomes available or have the infrastructure to receive them. 
 
Description ADMIRE 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution We are working with the University of Nottingham on the Assessing Donor kidneys and MonitorIng transplant REcipients (ADMIRE) project, which is using discarded whole kidneys from QUOD-X. The team at the University of Nottingham will be working on the second objective of our project, which relates to refining our scanning methods so they can easily be performed on the donor organ before it is transplanted and later in kidney recipients to monitor how well the transplanted organ is functioning without the need for biopsies. For this, we will first use kidneys that have been donated to research as they are not good enough quality to be transplanted. Detecting loss of kidney function by scanning an organ before it is transplanted and again after transplantation will allow to development of treatments to limit or even reverse disease progression, extending the life of transplants
Collaborator Contribution Expertise in whole organ ex-vivo scanning, analysis protocol and expertise in the integration of data.
Impact Funds were just awarded for this project. After this project is completed, we hope to move to a clinical trial.
Start Year 2021
 
Description Collaboration with Human Cell Atlas 
Organisation Human Cell Atlas
Sector Charity/Non Profit 
PI Contribution QUOD will serve as the primary supply route for hearts and kidneys to be used in Human Cell Atlas perfusion studies. QUOD will also supply tissue biopsies to HCA as need for more specialised studies.
Collaborator Contribution HCA is offering to lend considerable expertise, connections in the research community, reputational support, and ultimately some access to potential funders.
Impact No outputs yet.
Start Year 2018
 
Description Collaboration with UK Renal Imaging Network 
Organisation Kidney Research UK
Department UK Renal Imaging Network
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Our friends at Kidney Research UK connected us with the leads of the UK Renal Imaging Network to explore possibilities for the use of imaging in the assessment of organs for transplant. UKRIN was very receptive to these possibilities and a representative has formally joined the QUOD whole organ atlas project as the coordinator for whole organ imaging. We anticipate that whole-organ imaging data could be included in the organ atlases, adding a powerful macroscopic layer of detail to complement histology and molecular analyses. Multiple discussions were held throughout the year to plan pilot projects and funding for these is currently being sought. The QUOD contribution would be the facilitation of access to whole organs for research, as well as the knowledge in transplant success factors needed to correlate imaging results with transplant outcomes. Our researchers are also experts in the use of perfusion devices which would be essential in obtaining functional images during the organ transport stage.
Collaborator Contribution UKRIN provides expertise in the possibilities for using various imaging techniques, static as well as functional, for the assessment of organs. They also have the equipment, both fixed and mobile scanners, which would be used in this sort of project.
Impact We've recently got funding and started a new project, ADMIRE, that will be using imaging to find biomarkers for successful organ transplantation.
Start Year 2019
 
Description DEMISTIFI 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Rutger Ploeg and Maria Kaisar acted as Co-Investigators on the MICA - DEfining MechanIsms Shared across mulTI-organ FIbrosis to prevent the development of long-term multi-morbidity DEMISTIFI-Multi Morbidity project.
Collaborator Contribution Our vision is to identify clusters of multi-organ fibrotic diseases, referred to as Fibrotic Multi-Morbidity (FMM), with common pathogenic mechanisms that will benefit from shared management strategies, reducing the burden of treatment through therapeutic rationalisation, early identification of secondary organ involvement, and appropriate risk reduction strategies to increase the health-span of this group of patients.
Impact Talk to Maria
Start Year 2021
 
Description Dissemination and Funding Cooperation with JDRF 
Organisation Juvenile Diabetes Research Foundation (JDRF)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution QUOD has successfully engaged JDRF around the potential to supply their researchers with tissue and data from our resources.
Collaborator Contribution JDRF has indicated willingness to ring-fence funding for their researchers to use QUOD data and samples, as well as willingness to help inform the research community about QUOD resources. They have also indicated openness to helping with patient and public engagement through their communication channels.
Impact None yet.
Start Year 2018
 
Description Foundational Newcastle University Partnership 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Researchers from Newcastle University were co-applicants on the grant, and Newcastle has received disbursement of funds from the grant. We anticipate that researchers at Newcastle will execute many of the techniques needed to develop the organ atlases, while Oxford will organize collection and storage of the new biopsies and samples envisioned within the grant.
Collaborator Contribution Researchers from Newcastle University were co-applicants on the grant, and Newcastle has received disbursement of funds from the grant. We anticipate that researchers at Newcastle will execute many of the techniques needed to develop the organ atlases, while Oxford will organize collection and storage of the new biopsies and samples envisioned within the grant.
Impact Evaluation of CFTR expression and localisation in human pancreas; Participation in an advisory committee - Prof. James Shaw joins the Science and Research Advisory Group at Diabetes UK (2018); A press release, press conference or response to a media enquiry/interview - Press release on NDS main website; A formal working group, expert panel or dialogue - British Heart Foundation researchers at Newcastle Cardiovascular Research Group meeting Development of the online searchable atlases, representing a spectrum of normal, stressed, and chronically diseased organs. Development of the bespoke sample collection program. Working with applicants who want samples for researchers.
Start Year 2017
 
Description University College London 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We are working with UCL on the Assessing Donor kidneys and MonitorIng transplant REcipients (ADMIRE) project, which is using discarded whole kidneys from QUOD-X. The team at the UCL is responsible for the histology component for the project.
Collaborator Contribution Funds were just awarded for this project. After this project is completed, we hope to move to clinical trial.
Impact Funds were awarded for this project by Kidney Research UK.
Start Year 2021
 
Title SIGNET 
Description The SIGNET study opened to recruitment in September 2021. SIGNET will be the largest randomised controlled trial in organ donation, positioned perfectly to coordinate the unique strengths of the UK NHS infrastructure. It will evaluate the benefits of Simvastatin given to organ donors on outcomes in organ recipients. There is evidence that Simvastatin, a safe and commonly used drug, might limit the damage sustained by a donor's heart before it is transplanted. This drug has not been tested in large scale trials that assess outcomes important to patients. The SIGNET study will evaluate the benefits of a single dose of Simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2021
Development Status Under active development/distribution
Impact The Statins for Improving orGaN outcome in Transplantation (SIGNET) trial is a single blinded, randomised controlled trial of Simvastatin in organ donors. It will recruit 2,600 patients after the diagnosis of death by neurological criteria. A single dose of Simvastatin will be given after consent from the donor's family. The primary outcome is a composite of death, use of renal replacement therapy or mechanical cardiac support in cardiac recipients at 28 days. There are secondary clinical end points for other organ transplants as well as organ utilisation. The SIGNET study will be the largest global RCT ever performed in organ donation. 
 
Description Analysis of stress induced changes at ultrastructural level during pancreas preservation by transmission electron microscopy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N Kattner, D Tiniakos, Y Bury, K White, T Davey, L Eliasson, L Tindale, B Wagner, MM Honkanen-Scott, N Dyson, K Dalgarno, AM Ferreira-Duarte, RJ Ploeg, JAM Shaw, WE Scott III, "Analysis of stress induced changes at ultrastructural level during pancreas preservation by transmission electron microscopy." Presented as an Oral Presentation to 17th World Congress of the International Pancreas and Islet Transplant Association, Lyon, Catholic University, 2-5 July 2019. - *10 Best Abstracts.
Year(s) Of Engagement Activity 2019
 
Description Application of a quantitative scoring method for ultrastructural assessment of acute stress in pancreatic islets - Presentation at: 2021 British Transplant Society and NHS-BT Congress, 24-25 February, 2021. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N Dyson, N Kattner, MM Honkanen-Scott, B Hunter, J Doyle, K White, T Davey, RJ Ploeg, Y Bury, D Tiniakos, JAM Shaw, and WE Scott III: "Application of a quantitative scoring method for ultrastructural assessment of acute stress in pancreatic islets." Accepted for Oral Presentation at: 2021 British Transplant Society and NHS-BT Congress, 24-25 February, 2021.
Year(s) Of Engagement Activity 2021
 
Description Assessment of a novel hydrogel to replace extracellular matrix lost in isolated islets prior to transplantation: impact of collagen/alginate/fibrin hydrogel on islet morphology, viability and function 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N Kattner, S Miwa, D Cornell, N Al-Jahdhami, C Arden, K Dalgarno, AM Ferreira-Duarte, JAM Shaw, WE Scott III, "Assessment of a novel hydrogel to replace extracellular matrix lost in isolated islets prior to transplantation: impact of collagen/alginate/fibrin hydrogel on islet morphology, viability and function." Presented as an Oral Presentation to 17th World Congress of the International Pancreas and Islet Transplant Association, Lyon, Catholic University, 2-5 July 2019.
Year(s) Of Engagement Activity 2019
 
Description BTS - Brain death specific glomerular matrix degradation profiles are associated with long-term graft dysfunction in kidney transplant 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Rebecca Vaughan presented an abstract titled "Brain death specific glomerular matrix degradation profiles are associated with long-term graft dysfunction in kidney transplant" at the British Transplant Society Congress 2021. This abstract was selected for presentation as part of the 'Medawar Award Session', where this abstract and presentation was considered for the award along with three other researchers who also submitted abstracts for basic science in transplantation. Her research utilised 60 kidney biopsies from the QUOD biobank from both DBD and DCD donors.
Year(s) Of Engagement Activity 2021
 
Description British Heart Foundation researchers at Newcastle Cardiovascular Research Group meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Third sector organisations
Results and Impact Prof. John Dark presented the plans for the cardiac aspects of the QUOD expansion project at the regular meeting of Newcastle's cardiovascular research group. Prof. Dark invited representatives from the British Heart Foundation to hear the presentation. These representatives were initially enthusiastic at the invitation. We have not yet had a report from Prof. Dark and do not expect to before the submission deadline, but we expect that this presentation will stimulate powerful interest in using the resources of the QUOD expansion for cardiac research.
Year(s) Of Engagement Activity 2018
 
Description Development and application of the Newcastle Pancreas Endocrine Stress Score (NPESS) for ultrastructural assessment of pancreatic islet cells 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact N Dyson, N Kattner, MM Honkanen-Scott, B Hunter, J Doyle, K White, T Davey, RJ Ploeg, Y Bury, D Tiniakos, JAM Shaw, and WE Scott III: "Development and application of the Newcastle Pancreas Endocrine Stress Score (NPESS) for ultrastructural assessment of pancreatic islet cells." Accepted for Oral Presentation at: 11th EPITA Symposium & 40th AIDPIT Workshop, 25-26 January, 2021
Year(s) Of Engagement Activity 2021
 
Description Engagement with Charities for Dissemination and Funding 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact QUOD conducted one-to-one meetings with Diabetes UK and Kidney Research UK (as well as JDRF, reported elsewhere in outputs). These organisations had signed letters of support for QUOD's application to the MRC. These meetings served to provide an update on project progress, and advance discussions of concrete support for QUOD from these charities. All were in favour of using charity funds to support access for researchers to QUOD samples and data, as well as to collaboratively fund development of the organ pathology atlases beyond the anticipated scope of the MRC grant. All charities were also keen to leverage their communication channels to support QUOD engagement with research networks and patient/public audiences.
Year(s) Of Engagement Activity 2018,2019
 
Description Engagement with Diabetes Research and Wellness Foundation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact In December 2019 senior QUOD investigators met with the CEO and research director of DRWF, a connection facilitated by the QUOD islet platform lead. We introduced QUOD and detailed the resources coming available through the QUOD Expand project. DRWF were very interested in what we have to offer and open to considering proposals for funding some aspects of the work. We await a formal reply from them in the first half of 2020 to determine next steps.
Year(s) Of Engagement Activity 2019
 
Description Establishing a whole pancreas biopsy collection protocol for the Quality in Organ Donation (QUOD) Biobank 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact M Honkanen-Scott, M Bourne, J Doyle, N Dyson, Y Bury, RJ Ploeg, WE Scott III, JAM Shaw, "Establishing a whole pancreas biopsy collection protocol for the Quality in Organ Donation (QUOD) Biobank." Presented as an Oral Presentation to 17th World Congress of the International Pancreas and Islet Transplant Association, Lyon, Catholic University, 2-5 July 2019.
Year(s) Of Engagement Activity 2019
 
Description Establishing a whole pancreas biopsy collection protocol for the Quality in Organ Donation (QUOD) Biobank 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Formal presentation at the 2019 IPITA Congress in Lyon. Conference papers were not published, hence reported here.
Year(s) Of Engagement Activity 2019
URL http://www.ipita2019.org/programme-scientifique
 
Description European Society of Organ Transplantation (ESOT) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact At the end of August, QUOD attended the European Society of Organ Transplantation (ESOT) congress in Milan with a virtual booth. A number of researchers gave presentations based on their work using QUOD samples, these included Lestyn Shapey of Liverpool and Broadgreen University Hospital NHS Trust and Sadr Shaheed, Philip Charles, Ka Ho Tam and Rebecca Vaughan of the University of Oxford.
Year(s) Of Engagement Activity 2021
URL https://esot.org/
 
Description Exploratory meeting with CF Trust. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Third sector organisations
Results and Impact Top investigators from the QUOD Expand project met with the research director and CEO of CF Trust to lay out the vision for a lung pathology atlas based on organs to be acquired within QUOD Expand. CF Trust was extremely interested and receptive, and willing to explore funding options. Our lung platform coordinator has submitted a follow-up proposal as a preliminary step to a full-fledged application.
Year(s) Of Engagement Activity 2019
 
Description Is Seeing Believing? AI Image Analysis to Assess Donor Pancreas Organ Quality - BTS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact P Ezuma, L Bates, E Thompson, C Wilson*, WE Scott III*: "Is Seeing Believing? AI Image Analysis to Assess Donor Pancreas Organ Quality." Oral Presentation at The British Transplantation Society Annual Congress 2020, Belfast, UK, 4-6, March, 2020.
Year(s) Of Engagement Activity 2020
 
Description Is Seeing Believing? AI Image Analysis to Assess Donor Pancreas Organ Quality - NE Postgraduate Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact P Ezuma, L Bates, C Wilson*, WE Scott III*: "Is Seeing Believing? AI Image Analysis to Assess Donor Pancreas Organ Quality." Accepted as an Oral Presentation at The North East Postgraduate Conference, Newcastle upon Tyne, UK, 22, November, 2019.
Year(s) Of Engagement Activity 2019
 
Description Journey of a QUOD Sample: Donating to Transplant Research video 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact QUOD was successfully awarded funding through a Public Engagement with Research Seed Fund to produce a video for donors, donor families, clinicians, researchers and the wider public to raise awareness of the importance of organ transplantation research.
Year(s) Of Engagement Activity 2021
URL https://www.youtube.com/watch?v=wzDV3o_UPoU
 
Description Medical Research Charity Roundtable 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact On the basis of previous promising one-to-one conversations with Diabetes UK, Kidney Research UK, and JDRF, we assembled high-level representatives from each organisation to lay out the full vision for the QUOD whole organ pathology atlases and explore possibilities for these and other charities to co-fund the analytical work needed to produce these atlases. These charities were warmly supportive of QUOD's vision but indicated that bids for funding would likely fit better within already-established streams at each organisation. All representatives indicated a desire to continue to help QUOD-related researchers develop and fine-tune these bids and work has been ongoing since these meetings to identify relevant calls and shape appropriate proposals.
Year(s) Of Engagement Activity 2019
 
Description Oxford Ideas Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact QUOD had a booth at the Oxford Ideas Festival, a multi-date, multi-site showcase for scientific research designed for the general public. Our booth highlighted QUOD biopsy collection techniques and explained the importance of ongoing research to boost the quality and availability of organs for transplant. The audience ranged from ages 4 into the 80's, and we had several attendees visit who had benefitted from transplant (either themselves or a loved one). Several others signed up for the first time as organ donors.
Year(s) Of Engagement Activity 2018
URL https://www.nds.ox.ac.uk/news/nds-at-if-oxford
 
Description Oxford Science and Ideas Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact In 2020, QUOD participated in the Oxford Science and Ideas Festival with a virtual booth and was involved in an award-winning work experience programme for college students.
Year(s) Of Engagement Activity 2020,2021
 
Description Pancreas research community meeting at Newcastle 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof. James Shaw convened prominent researchers in pancreatic disease from across the United Kingdom for a discussion of the envisioned QUOD pathology atlas. Joining him from QUOD were Profs. Anna Gloyn and Paul Johnson to provide further insights on deeper levels of analysis planned for inclusion in the atlas. Around 40 researchers attended in total and interest in the atlas tool was very high. The session provided QUOD with invaluable feedback on how best to shape the atlas as a tool to aid researchers.
Year(s) Of Engagement Activity 2019
 
Description Potential for nanoengineering approaches in transplantation-regenerative medicine for the treatment of end-stage organ failure 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact WE Scott III, "Potential for nanoengineering approaches in transplantation-regenerative medicine for the treatment of end-stage organ failure." Presented as an Oral Presentation at: Royal Academy of Engineering - Young Researchers' Futures' Meeting: Nanoengineering approaches for biomedical applications, Edinburgh, UK, September 4-6, 2018.
Year(s) Of Engagement Activity 2018
 
Description Presentation at Departmental Away Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Prof. Rutger Ploeg included an overview of the plans for development of pathology atlases in his talk at the NDS Departmental Away Day. The audience included colleagues and postgraduate students from a broad range of medical research specialties.
Year(s) Of Engagement Activity 2019
URL https://www.nds.ox.ac.uk/news/nds-research-away-day-2019-winners-and-highlights
 
Description Presentation to Diabetes UK Clinical Study Group Chairs 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Senior QUOD investigators presented to Diabetes UK CSG Chair Meeting in November 2019. The presentation focused on the resources coming available in QUOD thanks to the QUOD Expand project funded by the MRC. The CSG group was extremely interested in the research possibilities that will be opened up, particularly in the use of diabetic pancreases, laying essential groundwork for an envisioned application for funding within the next year.
Year(s) Of Engagement Activity 2019
 
Description Presentations at 5th Annual QUOD Symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The 5th Annual QUOD Symposium was held in Manchester in November 2019. This year's symposium featured a strong presence from the coordinators of the organ atlas projects, as well as a presentation on whole-organ imaging from new collaborators at the UK Renal Imaging Network. Participants were quite excited by the work already completed towards the development of the atlases and enthusiasm remains high for the research possibilities opening up with the availability of whole organs.
Year(s) Of Engagement Activity 2019
 
Description Press release on NDS main website. 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact We released a news item on the main Nuffield Department of Surgical Science website, highlighting the MRC grant and the plans for the QUOD expansion. The news item closes with a call for interested researchers to contact QUOD for details on accessing the biobank, and a link to the QUOD website. The NDS communications office has also forwarded this item to the university list of relevant journalists, so there is possibility for further amplification. The item was just posted on the week of March 5, so it is too soon to know if any specific inquiries have arisen yet.
Year(s) Of Engagement Activity 2018
URL https://www.nds.ox.ac.uk/news/oxford-and-newcastle-receive-grant-for-vital-biobank-expansion
 
Description QUOD Islet Project discussd at JDRF Beta Cell Replacement Invited Consortium in NYC 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Over 60 international researchers attended this JDRF consortium meeting to update ideas and progress in the field of beta cell replacement. As part of his presentation Prof. Paul Johnson included an outline of plans for the QUOD Islet atlas project, which generated significant interest and support.
Year(s) Of Engagement Activity 2018
URL https://www.jdrf.org/blog/2018/11/16/meeting-minds-jdrf-fall-beta-cell-replacement-consortium-conven...
 
Description QUOD Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact QUOD regularly updates partners, researchers, patients and the wider public via our newsletter. The QUOD newsletter gives updates on public engagement, statistics and research using QUOD samples.
Year(s) Of Engagement Activity 2018,2019,2020,2021,2022
 
Description QUOD Presentation at UK Renal Imaging Network 3rd International Symposium on Functional Renal Imaging 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation by QUOD researcher Maria Kaisar regarding the resources coming available through QUOD Expand. Particular focus on potential for the use of whole kidneys in imaging and other projects. Follows on from collaboration plans between QUOD and UK Renal Imaging Network who put on this conference. QUOD also had a display at this conference which allowed for further opportunities for follow-up discussion with interested researchers.
Year(s) Of Engagement Activity 2019
URL https://www.nottingham.ac.uk/research/groups/spmic/research/uk-renal-imaging-network/3rd-renal-sympo...
 
Description QUOD at British Transplant Society/NHSBT Joint Annual Congress 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact QUOD was present in multiple channels at the 2019 BTS Congress. QUOD maintained a booth in the exhibition area throughout the event, with a presence for our core sample and data resources as well as for the MRC-funded expansions, including the organ atlases. QUOD investigators also had several talks throughout the event and several other researchers made presentations based on resources they had accessed via QUOD. Interest in QUOD's current and future resources was strong and we anticipate additional applications for samples and data to be submitted in the coming months.
Year(s) Of Engagement Activity 2019
URL https://bts.org.uk/events-meetings/annual-congress-2019/
 
Description QUOD cardiac stakeholder meeting on the 8th of June 2021 to discuss the heart atlas 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact We held a national QUOD cardiac stakeholder meeting on the 8th of June 2021 to discuss the heart atlas.

This was attended by and had presenters from Leeds, Liverpool, Oxford, and Newcastle universities as well as Kings College London.
Year(s) Of Engagement Activity 2021
 
Description Social media activities 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact QUOD regularly updates partners, researchers, patients and the public via social media. Specifically, our Twitter following has dramatically increased.
Year(s) Of Engagement Activity 2018,2019,2020,2021,2022
 
Description Standardized pathology reporting in donor pancreata within the quality and safety in organ donation (QUOD) tissue bank: a new resource for pancreatic research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Y Bury, N Kattner, N Dyson, C Jones, T Ness, R Coulthard, T Davey, L Eliasson, MM Honkanen-Scott, J Doyle, RJ Ploeg, G Klöppel, D Tiniakos, JAM Shaw and WE Scott III: "Standardized pathology reporting in donor pancreata within the quality and safety in organ donation (QUOD) tissue bank: a new resource for pancreatic research." Poster Presentation at: 32nd Congress of the ESP and XXXIII International Congress of the IAP, 6-8, December, 2020.
Year(s) Of Engagement Activity 2020
 
Description Survey of opinion of the public for whole organ research 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact We surveyed a public patient group of their opinion of whole organ research to better steer our project.
Year(s) Of Engagement Activity 2020
 
Description Transmission electron microscopy analysis of stress induced changes during pancreas preservation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Newcastle team presented findings from TEM studies of pancreases collected and processed thanks to the MRC QUOD funding at the 2019 World Congress of the International Pancreas and Islet Transplant Association (IPITA). Conference paper was not published, hence not reported in 'publications.'
Year(s) Of Engagement Activity 2019
URL http://www.ipita2019.org/programme-scientifique
 
Description Work Experience Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact NDS hosted dozens of students for a Work Experience week, with a day provided for six students to learn about research undertaken in the Transplant Centre. Students were introduced to multiple research projects, including QUOD, with the opportunity to practice taking biopsies (on fruit!) and looking at various human cells through the microscope. The overlap of clinical and research duties was a key theme through the day, and multiple students expressed appreciation at learning how these activities go hand-in-hand.
Year(s) Of Engagement Activity 2018