Acellular / Smart Materials - 3D Architecture: UK RMP Hub
Lead Research Organisation:
Imperial College London
Department Name: Materials
Abstract
We have identified a significant unmet need for improved therapies to treat tissue degenerative diseases and injuries in eye, liver and musculoskeletal tissue. These conditions represent a considerable obstacle to health and quality of life, as well as a staggering burden to the economy. We will combine the expertise of world-leading UK research groups to design and manufacture innovative biomaterials and drug delivery strategies to develop the needed therapies. Importantly, the focus will be on accelerating the process of translating our scientific discoveries and advances into real-world applications.
Our strategy stems from research on smart materials for specific clinical applications in eye, liver and musculoskeletal repair. We will investigate a range of highly innovative materials that can be tailored according to the specific clinical needs. We will develop exciting smart technologies where implanted materials will react to internal or external stimuli to, for example, release drugs that improve wound healing and reduce inflammation, or growth factors to enhance the regeneration of damaged or lost tissue. We will design flexible material platforms that can be easily modified to achieve a wide range of complex functionalities. We will introduce advanced manufacturing routes to produce materials that mimic the complex structure and multi-functionality of biological tissues. For applications in eye repair, we will develop injectable polymer sheets embedded with cells that would simultaneously replace lost retinal pigment epithelium and photoreceptors which cause visual impairment. We will also build 3D tissue engineered constructs for corneal repair. For our work on musculoskeletal tissue, we will develop injectable materials and 3D printed scaffold materials to repair fractures and defects in long bones, for example the tibia. The structure of the scaffolds will be designed to support and increase bone formation while embedded nanoparticles will be used for controlled delivery of growth factors. Our second target in the musculoskeletal tissue is shoulder rotator cuff repair where we have already novel electrospun material technologies in clinical trials. Here, we will improve these materials by introducing bioresponsive cues to regulate the activity of cells, modulate inflammation, enhance the formation of blood vessels and promote tissue growth. For osteoarthritis treatment, we will develop 3D constructs with controlled gradients that promote physical organisation of cartilage resulting in a more native-like functional material. The third clinical application targeted in this project is liver repair. We will aim to improve transplantation therapies by focussing on three promising pathways: 1) extending graft life-time using microparticles for localised delivery of immunomodulatory compounds, 2) enhancing cell engraftment with localised release of growth factors, and 3) developing innovative anti-fibrosis materials, including gels, patches and sprays. Importantly, we will complement our development pipeline with research on materials safety and immune response.
Through the UKRMP2 Acellular Hub we will steer our research towards applications with high success potential in alignment to identified clinical needs, manufacturing feasibility, regulatory compliance and product safety assurance.
Our strategy stems from research on smart materials for specific clinical applications in eye, liver and musculoskeletal repair. We will investigate a range of highly innovative materials that can be tailored according to the specific clinical needs. We will develop exciting smart technologies where implanted materials will react to internal or external stimuli to, for example, release drugs that improve wound healing and reduce inflammation, or growth factors to enhance the regeneration of damaged or lost tissue. We will design flexible material platforms that can be easily modified to achieve a wide range of complex functionalities. We will introduce advanced manufacturing routes to produce materials that mimic the complex structure and multi-functionality of biological tissues. For applications in eye repair, we will develop injectable polymer sheets embedded with cells that would simultaneously replace lost retinal pigment epithelium and photoreceptors which cause visual impairment. We will also build 3D tissue engineered constructs for corneal repair. For our work on musculoskeletal tissue, we will develop injectable materials and 3D printed scaffold materials to repair fractures and defects in long bones, for example the tibia. The structure of the scaffolds will be designed to support and increase bone formation while embedded nanoparticles will be used for controlled delivery of growth factors. Our second target in the musculoskeletal tissue is shoulder rotator cuff repair where we have already novel electrospun material technologies in clinical trials. Here, we will improve these materials by introducing bioresponsive cues to regulate the activity of cells, modulate inflammation, enhance the formation of blood vessels and promote tissue growth. For osteoarthritis treatment, we will develop 3D constructs with controlled gradients that promote physical organisation of cartilage resulting in a more native-like functional material. The third clinical application targeted in this project is liver repair. We will aim to improve transplantation therapies by focussing on three promising pathways: 1) extending graft life-time using microparticles for localised delivery of immunomodulatory compounds, 2) enhancing cell engraftment with localised release of growth factors, and 3) developing innovative anti-fibrosis materials, including gels, patches and sprays. Importantly, we will complement our development pipeline with research on materials safety and immune response.
Through the UKRMP2 Acellular Hub we will steer our research towards applications with high success potential in alignment to identified clinical needs, manufacturing feasibility, regulatory compliance and product safety assurance.
Technical Summary
In UKRMP2 Acellular we will develop and evaluate new classes of smart biomaterials for application in tissue regenerative therapies in three important clinical areas: eye, liver and musculoskeletal repair. The Hub structure is composed of 4 work packages (WPs) designed to maximise end clinical impact and 3 Strategic Gates as critical checkpoints. In WP1, we will develop a platform of innovative designer materials that enable tissue formation while simultaneously providing biological and biophysical cues for differentiation and hierarchical organisation of well vascularised tissues. The materials development pipeline will be complemented by research into advanced manufacturing strategies to develop 3D tissue engineered porous scaffolds and hierarchical structures. The research will be informed by immunological and safety considerations to enhance the translation potential. Importantly, the specific design parameters for the materials are defined by the clinical need (informed) and outlined in WPs 2-4 which focus on the three clinical exemplars, namely the eye, musculoskeletal repair and the liver. We aim to complete safety and efficacy pre-clinical testing for new biomaterials for cornea and retinal repair, enhancement of cell engraftment in the liver, and for lower limb, shoulder tendon and osteochondral applications. The role of 3 Strategic Gates to ensure the research and pre-clinical work is fully informed by experts in manufacturing, regulatory, immunology and safety considerations. Each strategic gate will be controlled by a group or panel of experts who will meet regularly to discuss the advances and prioritise technologies for clinical translation.
Planned Impact
The workplan for the next 5 years includes a spectrum of activities designed to benefit:
Academia: We will create a proactive and inclusive academic network to enhance collaboration within regenerative medicine and with allied/strategic fields across manufacturing and the cell-material interface. We anticipate immediate benefit to our ECRs and cohort of students who will have access to key training opportunities, including activities outside academic research. We will seek to position the UK as leader in regenerative medicine and will harness our international links to ensure a robust evaluation of our research, enhance staff development, and improve the translation pipeline. UKRMP2 is expected to yield scientific breakthroughs in materials science, regenerative medicine and advanced manufacturing, and to improve our understanding of the basic science of cell-material interactions.
NHS Clinicians: We have identified an unmet need for improved therapies to treat tissue degenerative diseases and injuries in eye, liver and musculoskeletal tissue. The economic burden of tissue degenerative diseases costs the NHS over £1bn/year, with musculoskeletal disease alone accounting for 8.8 million UK working days lost per year. Liver disease is the only major cause of death still increasing yearly (400% since 1970). Age related macular degeneration (AMD) currently affects more than 600k people in the UK and remains the leading cause of vision loss. By 2020, it is predicted that almost 700k people will have late-stage AMD in the UK. UKRMP2 aims to benefit patients and clinicians through the development of therapies that will improve healthcare and patient outcome across these devastating conditions. We will develop research with expectation for clinical translation in the next 5 years in the 3 areas. For the eye, we will gather pre-clinical data for the use of novel 3D biomaterials for corneal and retinal regeneration. We will lead the development of anti-fibrotic materials for treatment of liver fibrosis. In the musculoskeletal theme, we will work on early clinical adoption of shoulder tendon repair and lower limb bone repair. Critically, we will engage early with clinicians to define translational needs. Importantly, our workplan incorporates a Safety and Immunology strategic gate as a critical checkpoint to ensure product safety.
UK Industry: We will foster strong involvement with industry building upon the network generated in UKRMP1. The industrial partners in the UKRMP2 network will benefit of a platform for discussion and knowledge exchange where we will share perspectives, recognise translation and manufacturing bottlenecks, and identify skills gaps. Ultimately, the UKRMP2 Acellular Hub will create opportunities for commercial exploitation and creation of highly skilled jobs.
UK Government: In close collaboration with UKRMP and the Research Councils, we will establish communication links with the government and health agencies to increase awareness of our research, stimulate debate and inform and influence public policy in the regenerative medicine area.
Public Audience: We are passionate about communicating our work outside academia. Our dedicated outreach team will use a variety of dissemination opportunities to improve public understanding of regenerative medicine, showcase our work, open bilateral communication conduits, and educate and inspire the next generation of scientists. We will build on our extensive platform of public engagement from UKRMP1. Examples of the last 5 years include the BBSRC GB Bioscience Festival, Speakers4Schools, EPSRC, MRC and Royal Institution School Programmes and Lectures, as well as informal talks through Café Scientifique, Ask a Scientist, Meet the Expert and Pint of Science. Our award-winning Stem Cell Mountain (Oreffo, Evans, Dawson), developed with Winchester Science Centre has been taken to over 35 festivals in the last 4 years (e.g. Cheltenham, Glastonbury) and viewed by >300k people.
Academia: We will create a proactive and inclusive academic network to enhance collaboration within regenerative medicine and with allied/strategic fields across manufacturing and the cell-material interface. We anticipate immediate benefit to our ECRs and cohort of students who will have access to key training opportunities, including activities outside academic research. We will seek to position the UK as leader in regenerative medicine and will harness our international links to ensure a robust evaluation of our research, enhance staff development, and improve the translation pipeline. UKRMP2 is expected to yield scientific breakthroughs in materials science, regenerative medicine and advanced manufacturing, and to improve our understanding of the basic science of cell-material interactions.
NHS Clinicians: We have identified an unmet need for improved therapies to treat tissue degenerative diseases and injuries in eye, liver and musculoskeletal tissue. The economic burden of tissue degenerative diseases costs the NHS over £1bn/year, with musculoskeletal disease alone accounting for 8.8 million UK working days lost per year. Liver disease is the only major cause of death still increasing yearly (400% since 1970). Age related macular degeneration (AMD) currently affects more than 600k people in the UK and remains the leading cause of vision loss. By 2020, it is predicted that almost 700k people will have late-stage AMD in the UK. UKRMP2 aims to benefit patients and clinicians through the development of therapies that will improve healthcare and patient outcome across these devastating conditions. We will develop research with expectation for clinical translation in the next 5 years in the 3 areas. For the eye, we will gather pre-clinical data for the use of novel 3D biomaterials for corneal and retinal regeneration. We will lead the development of anti-fibrotic materials for treatment of liver fibrosis. In the musculoskeletal theme, we will work on early clinical adoption of shoulder tendon repair and lower limb bone repair. Critically, we will engage early with clinicians to define translational needs. Importantly, our workplan incorporates a Safety and Immunology strategic gate as a critical checkpoint to ensure product safety.
UK Industry: We will foster strong involvement with industry building upon the network generated in UKRMP1. The industrial partners in the UKRMP2 network will benefit of a platform for discussion and knowledge exchange where we will share perspectives, recognise translation and manufacturing bottlenecks, and identify skills gaps. Ultimately, the UKRMP2 Acellular Hub will create opportunities for commercial exploitation and creation of highly skilled jobs.
UK Government: In close collaboration with UKRMP and the Research Councils, we will establish communication links with the government and health agencies to increase awareness of our research, stimulate debate and inform and influence public policy in the regenerative medicine area.
Public Audience: We are passionate about communicating our work outside academia. Our dedicated outreach team will use a variety of dissemination opportunities to improve public understanding of regenerative medicine, showcase our work, open bilateral communication conduits, and educate and inspire the next generation of scientists. We will build on our extensive platform of public engagement from UKRMP1. Examples of the last 5 years include the BBSRC GB Bioscience Festival, Speakers4Schools, EPSRC, MRC and Royal Institution School Programmes and Lectures, as well as informal talks through Café Scientifique, Ask a Scientist, Meet the Expert and Pint of Science. Our award-winning Stem Cell Mountain (Oreffo, Evans, Dawson), developed with Winchester Science Centre has been taken to over 35 festivals in the last 4 years (e.g. Cheltenham, Glastonbury) and viewed by >300k people.
Publications

Abu Awwad HAM
(2020)
Genetically-programmed, mesenchymal stromal cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair.
in Journal of controlled release : official journal of the Controlled Release Society

Ahadian S
(2020)
Micro and nanoscale technologies in oral drug delivery.
in Advanced drug delivery reviews

Ajovalasit A
(2021)
Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing.
in Regenerative biomaterials

Anup A
(2024)
Embracing ethical research: Implementing the 3R principles into fracture healing research for sustainable scientific progress.
in Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Armstrong JPK
(2022)
Tissue Engineering Cartilage with Deep Zone Cytoarchitecture by High-Resolution Acoustic Cell Patterning.
in Advanced healthcare materials

Armstrong JPK
(2020)
Using Remote Fields for Complex Tissue Engineering.
in Trends in biotechnology

Armstrong JPK
(2019)
Spatiotemporal quantification of acoustic cell patterning using Voronoï tessellation.
in Lab on a chip

Armstrong JPK
(2020)
A blueprint for translational regenerative medicine.
in Science translational medicine

Armstrong JPK
(2019)
Emerging Technologies for Tissue Engineering: From Gene Editing to Personalized Medicine.
in Tissue engineering. Part A

Armstrong JPK
(2018)
Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning.
in Advanced materials (Deerfield Beach, Fla.)
Title | A Picture of Transparency |
Description | I took part in the 8-cubed project. This involved bringing together a scientist, a composer and musicians (https://www.rncm.ac.uk/research/research-centres-rncm/prism/prism-collaborations/8-cubed/). The composer and I spent time together, I showed her my research and discussed what I was trying to achieve. She used this to compose a piece of music that we worked on together. We gave the music the title A Picture of Transparency (https://www.rncm.ac.uk/research/research-centres-rncm/prism/prism-blog/prism-8-cubed/a-picture-of-transparency/). The music composed was inspired by the material processing and represents the initial state where the material components are individual and dissociated followed by the middle section where the materials mix and swirl together and begin to react with each other and eventually as they combine to process a single gel with a softness and transparency the music becomes less free and is now more rhythmically and tonally stable representing the gels we use in the contact lenses and corneal tissue engineering constructs |
Type Of Art | Composition/Score |
Year Produced | 2020 |
Impact | A concert of the piece was performed where the composer and I were available to discuss the music and the process in its creation. This generate an excellent discussion with the public about the research and how music and science can work together |
URL | https://www.rncm.ac.uk/research/research-centres-rncm/prism/prism-blog/prism-8-cubed/a-picture-of-tr... |
Description | 3D Printing for World Class Additive Biofabrication |
Amount | £964,323 (GBP) |
Funding ID | EP/V036025/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2020 |
End | 05/2022 |
Description | Bioengineering a cell-based cure for type 1 diabetes |
Amount | £1,953,548 (GBP) |
Organisation | Diabetes UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2023 |
End | 06/2028 |
Description | Clinical trial of cone photoreceptor transplantation for the treatment of retinal degeneration |
Amount | £4,036,096 (GBP) |
Funding ID | MR/V038559/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 09/2027 |
Description | Elucidating and modulating macrophage and stem cell responses to bioactive nanoclays for bone regeneration |
Amount | £473,805 (GBP) |
Funding ID | MR/V00543X/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 09/2024 |
Description | Engineering prosurvival synthetic microenvironment by modulating extrinsic and intrinsic factors in stem cell derive islet cells |
Amount | £2,933,210 (GBP) |
Organisation | Diabetes UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start |
Description | King's/Royal Free/UCL Gene Therapy Innovation Hub |
Amount | £6,067,629 (GBP) |
Funding ID | MR/V030191/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 09/2026 |
Description | Mechanobiology-based medicine |
Amount | £302,859 (GBP) |
Funding ID | EP/W004623/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 12/2023 |
Description | University of Liverpool: Professor Rachel Williams - MRC DRFT |
Amount | £1,300,000 (GBP) |
Funding ID | MR/W01470X/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2022 |
End | 12/2024 |
Title | Research Data Supporting "Engineering Anisotropic Muscle Tissue Using Acoustic Cell Patterning" |
Description | Raw research data supporting the publication: Armstron, JPK et al., "Engineering anisotropic muscle tissue using acoustic cell paterning", Advanced Materials, DOI: 10.1002/adma.201802649 (2018) |
Type Of Material | Database/Collection of data |
Year Produced | 2018 |
Provided To Others? | Yes |
Title | Research data supporting "Buoyancy-Driven Gradients for Biomaterial Fabrication and Tissue Engineering" |
Description | Research data supporting the publication: Li C. et al., Advanced Materials, 2019, DOI: 10.1002/adma.201900291 |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Title | Research data supporting "Considerations for Implementing Electronic Laboratory Notebooks in an Academic Research Environment" |
Description | Research data supporting the publication: Higgins SG, Nogiwa-Valdez AA, Stevens MM, Considerations for Implementing Electronic Laboratory Notebooks in an Academic Research Environment, Nature Protocols, 2021. This repository contains the raw survey data of 172 current and historic electronic laboratory notebook (ELN) software packages. Main files: "ELN_Review_Higgins_2021_Survey.csv" = raw survey data in 'tidy' data format "ELN_Review_Higgins_2021.Rmd" = an R Markdown File (R Notebook) that takes the survey data as input and produces summary statistics and plots. This file was written using R Studio as the IDE. Derived files, generated from those above: "ELN_Review_Higgins_2021.nb.html" = a self-contained HTML file that is automatically generated by R Studio, based on the markdown file. This can be opened in any web browser to allow manual inspection of the code and comments without the need for specialist software. Embedded within this file is also the original markdown script (i.e. a copy of the code in "ELN_Review_Higgins_2021.Rmd") "ELN_Review_Higgins_2021_Lifetimes_Interactive_Figure1.html" = an HTML file generated by the script above via the plotly package. It contains an interactive version of the ELN survey data, allowing the user to hover over the timeline and explore the data. "ELN_Review_Higgins_2021_Timeline.pdf" = static version of ELN timeline, used to generate figure in main manuscript. "ELN_Review_Higgins_2021_Releases-Per-Year.pdf" = static version of number of new ELNs per year, used to generate figure in main manuscript. This survey was generated from a mixture of primary and secondary sources (see references for secondary sources). |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
URL | https://zenodo.org/record/5012728 |
Title | Research data supporting "Functionalisation of PLLA with Polymer Brushes to Trigger the Assembly of Fibronectin into Nanonetworks" |
Description | Raw research data supporting the publication Sprott et al. "Functionalisation of PLLA with Polymer Brushes to Trigger the Assembly of Fibronectin into Nanonetworks", doi: 10.1002/adhm.201801469 |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | This research data led to the publication "Functionalisation of PLLA with Polymer Brushes to Trigger the Assembly of Fibronectin into Nanonetworks", doi: 10.1002/adhm.201801469 |
URL | https://doi.org/10.5525/gla.researchdata.715 |
Title | Research data supporting "In vivo biocompatibility and immunogenicity of metal-phenolic gelation" |
Description | Research raw data supporting the publication: Bjornmalm M., et al., 2019, Chemical Science, DOI:101039/c9sc03325d |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
URL | https://zenodo.org/record/3434518 |
Title | Research data supporting "Nanoscale molecular quantification of stem cell-hydrogel interactions" |
Description | Raw data supporting: Maynard S. et al., 2020, ACS Nano, DOI: 10.1021/acsnano.0c07428. |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://zenodo.org/record/4281239 |
Title | Research data supporting "Remote magnetic nanoparticle manipulation enables the dynamic patterning of cardiac tissues" |
Description | Research data supporting the publication: Zwi-Dantsis et al., 2020, Advanced Materials, DOI: 10.1002/adma.201904598. |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
URL | https://zenodo.org/record/3560064 |
Title | Research data supporting "Residue-Specific Solvation Directed Thermodynamic and Kinetic Control over Peptide Self-Assembly with 1D/2D Structure Selection" |
Description | Experimental research raw data supporting the publication by Lin, Y. et al, 2019, "Residue-Specific Solvation Directed Thermodynamic and Kinetic Control over Peptide Self-Assembly with 1D/2D Structure Selection", ACS Nano. DOI: 10.1021/acsnano.8b08117. Molecular simulation data is available upon reasonable request from irene.yarovsky@rmit.edu.au. |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
URL | https://zenodo.org/record/2543225 |
Description | Angiogeneisis - Vasculature development- collaboration |
Organisation | Ludwig Boltzmann Society |
Department | Ludwig Boltzmann Institute for Experimental and Clinical Traumatology |
Country | Austria |
Sector | Academic/University |
PI Contribution | Development of new ex vivo approaches to angiogenesis and vascular development - specifically chorioallantoic membrane models - Development in partnership of a new decellularised scaffold matrix approach evaluation for skeletal tissue engineering. |
Collaborator Contribution | Innovative vascular scaffolds - using placental tissue (Human) |
Impact | Publications and joint grant applications |
Start Year | 2015 |
Description | Designing peptide hydrogel bioinks for 3D bioprinting applications |
Organisation | Manchester BIOGEL |
Country | United Kingdom |
Sector | Private |
PI Contribution | Developed the hydrogel technology used for 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided a financial contribution University of Manchester (Dr. S. Barg and J. Hoyland) provided expertise in 3D Bioprinting, Cell Culture and Tissue Engineering |
Impact | This is an interdisciplinary collaboration involving the field of Material Science, Cell Culture & Biology and 3D Bioprinting |
Start Year | 2020 |
Description | Designing peptide hydrogel bioinks for 3D bioprinting applications |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developed the hydrogel technology used for 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided a financial contribution University of Manchester (Dr. S. Barg and J. Hoyland) provided expertise in 3D Bioprinting, Cell Culture and Tissue Engineering |
Impact | This is an interdisciplinary collaboration involving the field of Material Science, Cell Culture & Biology and 3D Bioprinting |
Start Year | 2020 |
Description | Developing new 3D-hydrogel models of the human mammary gland to investigate breast cancer initiation |
Organisation | Manchester BIOGEL |
Country | United Kingdom |
Sector | Private |
PI Contribution | Developed hydrogel technology for 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided funding for the project Manchester Collaborators (Drs. A. Guilmore, J. Swift and M. Domingo) provided expertise in cell culture and 3D bioprinting |
Impact | This is a interdisciplinary collaboration involved the following disciplines: Material Science, 3D Bioprinting, Cell Culture and Cancer |
Start Year | 2019 |
Description | Developing new 3D-hydrogel models of the human mammary gland to investigate breast cancer initiation |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developed hydrogel technology for 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided funding for the project Manchester Collaborators (Drs. A. Guilmore, J. Swift and M. Domingo) provided expertise in cell culture and 3D bioprinting |
Impact | This is a interdisciplinary collaboration involved the following disciplines: Material Science, 3D Bioprinting, Cell Culture and Cancer |
Start Year | 2019 |
Description | Engineering nerve guidance conduit - self-assembling peptide hydrogel composites for large nerve gap repair and regeneration |
Organisation | Manchester BIOGEL |
Country | United Kingdom |
Sector | Private |
PI Contribution | Developed the Hydrogel technology used for 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided a financial contribution University of Manchester (Dr. A Reid) provided expertise in cell culture & biology as well as tissue engineering |
Impact | This is a interdisciplinary collaboration with involved the fields of Material Science, Cell Culture & Biology and Tissue Engineering |
Start Year | 2020 |
Description | Engineering nerve guidance conduit - self-assembling peptide hydrogel composites for large nerve gap repair and regeneration |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developed the Hydrogel technology used for 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided a financial contribution University of Manchester (Dr. A Reid) provided expertise in cell culture & biology as well as tissue engineering |
Impact | This is a interdisciplinary collaboration with involved the fields of Material Science, Cell Culture & Biology and Tissue Engineering |
Start Year | 2020 |
Description | Tissue engineering the oesophagus |
Organisation | Manchester BIOGEL |
Country | United Kingdom |
Sector | Private |
PI Contribution | Developed in the hydrogel technology used for the 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided financial contribution University of Manchester (Drs J. Gough and S. Herrick) provided expertise in the field of cell culture & biology and tissue engineering |
Impact | This is an interdisciplinary project involving the fields of Materials Science, Cell Culture and Biology and Tissue Engineering |
Start Year | 2019 |
Description | Tissue engineering the oesophagus |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developed in the hydrogel technology used for the 3D cell culture |
Collaborator Contribution | Manchester BIOGEL provided financial contribution University of Manchester (Drs J. Gough and S. Herrick) provided expertise in the field of cell culture & biology and tissue engineering |
Impact | This is an interdisciplinary project involving the fields of Materials Science, Cell Culture and Biology and Tissue Engineering |
Start Year | 2019 |
Title | DECELLULARIZED TISSUE HYDROGELS |
Description | The invention provides a decellularized tissue hydrogel cross-linked with a polyphenol, and a method of preparing a cross-linked decellularized tissue hydrogel, the method comprising the steps of: a) providing at least one decellularized tissue hydrogel; and b) cross-linking the at least one decellularized tissue hydrogel with a polyphenol. |
IP Reference | WO2022229653 |
Protection | Patent / Patent application |
Year Protection Granted | 2022 |
Licensed | No |
Impact | Granted to Prof Lisa White and Prof Joshua Jones, University of Nottingham. Work in progress |
Title | Polymer-clay composite and organoclay (University of Southampton, Professor Richard Oreffo) |
Description | The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided. |
IP Reference | |
Protection | Patent granted |
Year Protection Granted | 2019 |
Licensed | Yes |
Impact | This new nanoclay gel technology (Renovite®) will transform orthopaedic surgery. |
Title | Scaffold |
Description | A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer. |
IP Reference | US10500310 B2 |
Protection | Patent granted |
Year Protection Granted | 2019 |
Licensed | No |
Impact | N/A as yet |
Title | Injector for subretinal delivery |
Description | The research resulted in development of a pneumatic injector for subretinal delivery of hydrogel scaffolds. A proof of concept prototype was achieved with ex vivo demonstration of use on a porcine eye model. |
Type | Therapeutic Intervention - Surgery |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2024 |
Development Status | Under active development/distribution |
Impact | n/a |
Title | SLA 3D printable scaffold |
Description | Completed pre-clincal validation of a biodegradable, SLA 3D printable polymer for bone tissue engineering and non-union fracture repair Currently undergoing GMP manufacture and ISO testing. |
Type | Therapeutic Intervention - Surgery |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2024 |
Development Status | Under active development/distribution |
Impact | n/a |
Description | Advanced Materials in Medicine (AMM): Biomaterials Translation Virtual Workshop (University of Manchester, Professor Alberto Saiani) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Prof Richard Oreffo opened the workshop with his keynote speech entitled "Regenerative Musculoskeletal Medicine: Skeletal cell-based strategies for bone repair from bench to clinic". Dr James Armstrong also gave a talk, entitled "Controlling the assembly of biomaterials and tissues for regenerative medicine. The program included rapid fire presentation competitions and a panel session to discuss 'career opportunities after the PhD' which was well received by ECRs. Dr Armstrong shared his journey as a UKRMP fellow. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.pankhurst.manchester.ac.uk/2021/06/02/advanced-materials-in-medicine-amm-biomaterials-tr... |
Description | Armstrong talk - Acoustic assembly of biomaterials and engineered tissues |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A research talk presented to an international audience |
Year(s) Of Engagement Activity | 2020 |
Description | Armstrong talk - Acoustic cell patterning for musculoskeletal tissue engineering - Acoustofluidics |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A research talk presented to an international audience |
Year(s) Of Engagement Activity | 2020 |
Description | Armstrong talk - Controlling the assembly and structure of biomaterials and engineered tissues - Bath |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | A research talk presented at the University of Bath Departmental Seminar |
Year(s) Of Engagement Activity | 2020 |
Description | Armstrong talk - Using sound waves to build tissues and biomaterials |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | A research talk presented as part of the Imperial College Departmental Seminars |
Year(s) Of Engagement Activity | 2020 |
Description | BMES Cell & Molecular Bioengineering Conference (Keynote Lecture), Key Largo, FL, USA, 5 January 2018 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Chan talk - Bioengineering strategies for intrauterine adhesion and endometrial regeneration - ISSUOG |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A research talk presented at the ISSUOG Virtual World Congress 2020 |
Year(s) Of Engagement Activity | 2020 |
Description | Designing the cell-material interface for regenerative engineering |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A keynote talk delivered to an international audience by Prof Molly Stevens at the Rock Stars of Regenerative Engineering event organised by Regenerative Engineering Society of AIChE. |
Year(s) Of Engagement Activity | 2021 |
Description | Exhibition Road Festival |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Public engagement event to promote scientific research of Imperial College and Exhibiiton Road museums. |
Year(s) Of Engagement Activity | 2019 |
Description | Expert for SECEC Podcast Interview |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | O-108 Dermal Patch Augmented Versus Standard Rotator Cuff Repair 15min. Radio-Interview with the author, Mr Priyadarshi Amit, and Prof. Andrew Carr - SECEC expert for this topic |
Year(s) Of Engagement Activity | 2021 |
Description | Improving the world though engineering - Engineering Day, Wirral Arts Festival (sponsored by IMechE) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Public lecture designed to highlight the breadth of engineering and how it influences our lives. It involved a lecture and a panel discussion to answer questions |
Year(s) Of Engagement Activity | 2019 |
Description | Invited Presentation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Over 125 people attended a workshop on "Safety and Stem Cell-Derived Cell Replacement Therapies' on 7th/8th October 2019 in Edinburgh, which raised a number of issues and approaches aorund the safety and application of stem cell derived cell therapies. The workshop provided a forum to discuss the safety around cell therapies. |
Year(s) Of Engagement Activity | 2019 |
Description | Invited lecture at the Medical Research Council Lifecourse Epidemiology Unit - Musculoskeletal Lecture Series |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Third sector organisations |
Results and Impact | Online Seminar: "Regenerative Musculoskeletal Medicine: Skeletal cell based strategies for bone regeneration from bench to clinic" on Tuesday 26th January 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | Invited presentation at RAMS2019 (recent appointments in materials science) - Liverpool |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | RAMS2019 aims to connect and support early career academics and senior post-doctoral researchers in industry or academia working in Materials Science. The event involved being a plenary speaker as well as joining in the panel discussion to mentor and inspire early career academics and researchers. |
Year(s) Of Engagement Activity | 2019 |
Description | Invited seminar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Research seminar to Biomedical Engineers at the University of Glasgow. Introducing the Ophthalmic Bioengieering research topic. Developing new collaborations |
Year(s) Of Engagement Activity | 2020 |
Description | KTN Workshop on additive biofabrication |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | A dissemination event to inform business on the role of additve manufacturing in regenerative medicine. |
Year(s) Of Engagement Activity | 2020 |
Description | Keynote speaker at symposium in Spain |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Keynote talk "New approaches to skeletal cell based bone regeneration: repair, restore and recreate" to an audience of people working in Biomedical Institutes in Coruña and Santiago and students (Biology, Medicine and Masters students). |
Year(s) Of Engagement Activity | 2019 |
Description | Keynote speaker at the Workshop of Biomaterials Translation. Talk title "Regenerative Musculoskeletal Medicine: Skeletal cell based strategies for bone repair from bench to clinic" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | A yearly event organised in Manchester. A free workshop organised by the Manchester Biomaterials Network (ManBioMat) and held as part of the Advanced Materials In Medicine @ Manchester initiative (Biomaterials Theme). The workshop is supported by the UKRMP2 Acellular Hub, RSC Biomaterials Chemistry Interest Group and Manchester BIOGEL. In the morning they have a mix of presentations from established PIs and early career PIs and in the afternoon PhD and PDRA presentation / competitions. Invite to give 35 min keynote as have been active in both UKRMP and translation all career. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.eventbrite.com/e/biomaterials-translation-workshop-2021-tickets-154556391327 |
Description | London International Youth Forum |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Schools engagement event to promote scientific research of Imperial College |
Year(s) Of Engagement Activity | 2019 |
Description | Materials to shape our vision; How advanced materials are fighting the loss of sight |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | I presented to around 20 members of the general public in a pub. There was a lot of interest in the materials I showed them and this generated a lot of discussion. On the back of this i have been invited to take part in two more similar events |
Year(s) Of Engagement Activity | 2019 |
Description | Moore Outreach - Wohl Reach Out Lab |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | outreach aimed at engaging school children in STEM subjects |
Year(s) Of Engagement Activity | 2019 |
Description | Moore Talk - BioMedEng19 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk presented to an international audience |
Year(s) Of Engagement Activity | 2019 |
Description | Moore Talk - Orthopaedic Research Society Annual Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research poster presented to an international audience |
Year(s) Of Engagement Activity | 2019 |
Description | Moore-Talk International Cartilage Regeneration and Joint Preservation Society World Congress (ICRS) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Two research posters presented to an international audience |
Year(s) Of Engagement Activity | 2019 |
Description | New Forest Show- Public Science Engagement |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Large Stand on Bone Research at the New Forest Show - Aim was to explain Bone Research undertaken at University of Southampton Bone and Joint Research Group- throughput of 100s of people over three days - sparked young children and school children interest in bone research. |
Year(s) Of Engagement Activity | 2014,2016,2018,2019,2022,2023 |
Description | New hybrid materials for ultrasensitive biosensing and regenerative medicine |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary talk by Prof Molly Stevens IUPAC-World Polymer Congress MACRO 2020+ , Jeju, Korea and Virtual, 18 May 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | New materials based strategies for regenerative medicine |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A talk delivered to an international audience by Prof Molly Stevens at TCES 2021, 6 July 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | Public lecture to the Thirteen Society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | This was a presentation to an audience of around 70 retired professionals who organise a wide ranging programme of interesting presentations. I introuduced the importance of engineering and materials in overcoming vision loss. It generated a lot of interesting questions. I received very positive feedback, particularly around being able to present a complex subject in a very accessible way to the intellegent generalist. |
Year(s) Of Engagement Activity | 2020 |
Description | STEM Ambassador: Lifelab "Meet the Scientist" sessions (5): 18/03/19, 09/05/19, 19/06/19, 24/09/19, 14/01/2020 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Elloise Matthews (PhD student funded by Rosetrees) Led discussion about skeletal stem cells and need for investigation in this area (and personal experience of a career in research). |
Year(s) Of Engagement Activity | 2019,2020 |
Description | SciBar presentation - Kirby, Liverpool |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Presentation in a Pub in Liverpool to highlight sciences to the public |
Year(s) Of Engagement Activity | 2019 |
Description | SciBar presentation Liverpool City Centre |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Presentation in a Pub in Liverpool to highlight sciences to the public |
Year(s) Of Engagement Activity | 2019 |
Description | Sky News report on our mineralising technology for enamel regeneration |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | 2018 Sky News reports on our mineralisation platform for enamel regeneration: https://news.sky.com/story/scientists-claim-they-can-regenerate-tooth-enamel-to-prevent-decay-11392540 |
Year(s) Of Engagement Activity | 2018 |
URL | https://news.sky.com/story/scientists-claim-they-can-regenerate-tooth-enamel-to-prevent-decay-113925... |
Description | Stevens Plenary Talk - RSC Biomaterials Chemistry Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A research talk presented to an international audience |
Year(s) Of Engagement Activity | 2020 |
Description | Stevens keynote talk - 11th World Biomaterials Congress |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A research talk presented to an international audience |
Year(s) Of Engagement Activity | 2020 |
Description | Stevens talk - 2018 MRS Fall Meeting, Boston, MA, USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - 2018 MRS Spring Meeting & Exhibit, Phoenix, AZ, USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - 255th ACS National Meeting and Exposition, New Orleans, LA, USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - 6th International Conference on Multifunctional, Hybrid and Nanomaterials, Sitges, Spain |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Materials in Society Lecture given to an international audience |
Year(s) Of Engagement Activity | 2019 |
Description | Stevens talk - ACS National Meeting and Exhibition, Orlando, USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Lecture delivered to an international audience |
Year(s) Of Engagement Activity | 2019 |
Description | Stevens talk - Applied Nanotechnology and Nanoscience International Conference (Plenary), Berlin, Germany |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - Beilstein Nanotechnology Symposium (Speaker & Co-organizer), Rüdesheim, Germany |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - Controlled Release Society Annual Meeting (Plenary Lecture), New York, USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - Dutch Polymer Days Congress (Keynote Lecture), Lunteren, Netherlands |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - E-MRS Spring Meeting 2018 (Plenary Lecture), Strasbourg, France |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - Emerging technologies and medical devices event, London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A research talk presented to an international audience |
Year(s) Of Engagement Activity | 2020 |
Description | Stevens talk - European Polymer Congress, Crete, Greece |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary lecture delivered to an international audience. |
Year(s) Of Engagement Activity | 2019 |
Description | Stevens talk - GRC on Biomaterials and Tissue Engineering, Castelldefels, Spain |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Lecture delivered to an international audience. |
Year(s) Of Engagement Activity | 2019 |
Description | Stevens talk - Gordon Research Conference: Bioinspired Materials, Les Diablerets |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - IUPAC 2019, Paris, France |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Lecture delivered to an international audience. |
Year(s) Of Engagement Activity | 2019 |
Description | Stevens talk - International Symposium on Macrocyclic and Supramolecular Chemistry, Lecce, Italy |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary lecture delivered to an international audience. |
Year(s) Of Engagement Activity | 2019 |
Description | Stevens talk - Israel Materials Engineering Conference (Plenary Lecture), Dead Sea, Israel |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - Nanotexnology 2018 (Plenary), Thessaloniki, Greece |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Stevens talk - ORS 2018 Annual Meeting, New Orleans, LA, USA |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Research talk given to international audience. |
Year(s) Of Engagement Activity | 2018 |
Description | Talk - at Translate Conference - Science Translational Medicine |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk - New Approaches to Value-Driven Device Developments - virtual conference attended by 100 plus participants, with questions after the talk |
Year(s) Of Engagement Activity | 2021 |
Description | Talk The role of inflammation in tendinopathy |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Novartis Tendinopathy Strategic Meeting (virtual) which sparked discussion to inform decision making |
Year(s) Of Engagement Activity | 2020 |
Description | Talk at UKRMP2 Smart Materials Hub Annual Meeting, Grand Harbour Hotel, Southampton Nov 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Gave talk "Introduction to MSK material development and the pathway to in vivo testing |
Year(s) Of Engagement Activity | 2019 |
Description | TalkProfessor Andy Carr, International Strategy Advisory Board o Offer views on the importance of the initiative as a way of encouraging new ideas in the community, as well as the need for collaboration and big thinking in pain research, both nationally and internationally |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Advanced Pathways Discovery Programme Introduction Webinar to inform |
Year(s) Of Engagement Activity | 2020 |
Description | The European Research Council highlights our work on hierarchical mineralisation for bone and dental regeneration. |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | The European Research Council highlights our work on hierarchical mineralisation: https://erc.europa.eu/projects-figures/stories/regenerating-bones-and-teeth |
Year(s) Of Engagement Activity | 2018 |
URL | https://erc.europa.eu/projects-figures/stories/regenerating-bones-and-teeth |
Description | The Naked Scientists radio interview related to our work on enamel regeneration |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | The Naked Scientists radio interview: https://www.thenakedscientists.com/podcasts/short/regenerating-tooth-enamel |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.thenakedscientists.com/podcasts/short/regenerating-tooth-enamel |
Description | The Telegraph reports on our mineralising technology for enamel regeneration |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | The Telegraph reports on our mineralisation platform for enamel regeneration: www.telegraph.co.uk/news/2018/06/02/scientists-develop-method-could-help-regenerate-tooth-enamel/ |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.telegraph.co.uk/news/2018/06/02/scientists-develop-method-could-help-regenerate-tooth-ena... |
Description | The Times reports on our mineralising technology for enamel regeneration |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | The Times reports on our mineralisation platform for enamel regeneration: www.thetimes.co.uk/article/new-hope-for-old-teeth-as-scientists-try-to-regrow-enamel-npv6xzbld |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.thetimes.co.uk/article/new-hope-for-old-teeth-as-scientists-try-to-regrow-enamel-npv6xzbl... |
Description | UKRMP Regenerative Medicine Showcase 2023 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | o Conference: UKRMP Regenerative Medicine Showcase 2023 o Date and place: McEwan Hall, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, United Kingdom, 8-10 November 2023 o Type of presentation: Oral Presentation (dr Jonathan Wojchiechowski) o Title: Post-printing functionalisation of 3D printed hydrogels as a modular biomaterials platform. |
Year(s) Of Engagement Activity | 2023 |
Description | UKRMP Regenerative Medicine Showcase 2023 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | o Conference: UKRMP Regenerative Medicine Showcase 2023 o Date and place: McEwan Hall, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, United Kingdom, 8-10 November 2023 o Type of presentation: Oral Presentation (talk by Rachael Pearson, KCL) o Title: vivo testing of hydrogel scaffolds for retinal cell transplantation [talk by Rachael Pearson, KCL]. (Thomas) |
Year(s) Of Engagement Activity | 2023 |
Description | UKRMP Regenerative Medicine Showcase 2023 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | o Conference: UKRMP Regenerative Medicine Showcase 2023 o Date and place: McEwan Hall, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, United Kingdom, 8-10 November 2023 o Type of presentation: Poster (Lisha Zhong) o Title: Synthesis of a de novo Bruch's-like membrane by hSPC-derived Retinal Pigment Epithelium. |
Year(s) Of Engagement Activity | 2023 |
Description | UKRMP Regenerative Medicine Showcase 2023 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | o Conference: UKRMP Regenerative Medicine Showcase 2023 o Date and place: McEwan Hall, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, United Kingdom, 8-10 November 2023 o Type of presentation: Oral Presentation (Prof Molly Stevens) o Title: Challenges for biomaterials in Regenerative medicine |
Year(s) Of Engagement Activity | 2023 |
Description | UKRMP Regenerative Medicine Virtual Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Organised by MRC. Five speakers have been invited from the Smart Materials Hub: Professor Molly Stevens, Professor Stuart Forbes, Professor Manuel Salmeron-Sanchez, Professor Rachel Williams and Associate Professor Pierre-Alexis Mouthuy. The conference will also hold a session of flash talks open to all PhD students, post-doctoral researchers and fellows affiliated with UKRMP entitled: (1) Smart Materials: how Smart are they? (2) Making a Cell Therapy (3) Endogenous Repair- Can we do it? This free conference is open to all interested in regenerative medicine. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.ukrmp.org.uk/regenerative-medicine-and-advanced-therapeutics-virtual-conference/ |
Description | Women in Engineering |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | This was an event organised by the IET to encourage young women into engineering careers by presenting the steps I had taken to build my career |
Year(s) Of Engagement Activity | 2019 |