Tissue-resident macrophages and malignant progression of ovarian cancer
Lead Research Organisation:
King's College London
Department Name: Immunology Infection and Inflam Diseases
Abstract
THypothesis: This project will test the hypothesis that specific axes of interaction between TRM and disseminated cancer cells promotes their malignant progression and the development of invasive disease.
Objecitve: Our objective is to unravel the molecular basis of these interactions that may in turn reflect viable clinical targets.
Approach: Our approach includes in-depth descriptive studies coupled with in vivo validation in experimental models, with the aim to achieve a finer definition of TRM and identify new therapeutic targets. We will build on our previous work and map the molecular dialogue between TRM and cancer cells using parallel single cell analysis in new clinically relevant models of HGSC. We will also generate new and unique tools to probe the function of TRM in these models and validate their roles in tumour progression.
Outcome: These studies will provide new insights into the tumour-promoting functions of TRM and reveal molecular targets to support the development of TRM targeted therapies for human cancer.
Objecitve: Our objective is to unravel the molecular basis of these interactions that may in turn reflect viable clinical targets.
Approach: Our approach includes in-depth descriptive studies coupled with in vivo validation in experimental models, with the aim to achieve a finer definition of TRM and identify new therapeutic targets. We will build on our previous work and map the molecular dialogue between TRM and cancer cells using parallel single cell analysis in new clinically relevant models of HGSC. We will also generate new and unique tools to probe the function of TRM in these models and validate their roles in tumour progression.
Outcome: These studies will provide new insights into the tumour-promoting functions of TRM and reveal molecular targets to support the development of TRM targeted therapies for human cancer.
Technical Summary
Hypothesis: This project will test the hypothesis that specific axes of interaction between Tissue-Resident Macrophages (TRM) and disseminated cancer cells promotes their malignant progression and the development of invasive disease.
Objecitve: Our objective is to unravel the molecular basis of these interactions that may in turn reflect viable clinical targets.
Approach: Our approach includes in-depth descriptive studies coupled with in vivo validation in experimental models, with the aim to achieve a finer definition of TRM and identify new therapeutic targets. We will build on our previous work and map the molecular dialogue between TRM and cancer cells using parallel single cell analysis in new clinically relevant models of HGSC. We will also generate new and unique tools to probe the function of TRM in these models and validate their roles in tumour progression.
Outcome: These studies will provide new insights into the tumour-promoting functions of TRM and reveal molecular targets to support the development of TRM targeted therapies for human cancer.
Objecitve: Our objective is to unravel the molecular basis of these interactions that may in turn reflect viable clinical targets.
Approach: Our approach includes in-depth descriptive studies coupled with in vivo validation in experimental models, with the aim to achieve a finer definition of TRM and identify new therapeutic targets. We will build on our previous work and map the molecular dialogue between TRM and cancer cells using parallel single cell analysis in new clinically relevant models of HGSC. We will also generate new and unique tools to probe the function of TRM in these models and validate their roles in tumour progression.
Outcome: These studies will provide new insights into the tumour-promoting functions of TRM and reveal molecular targets to support the development of TRM targeted therapies for human cancer.
Organisations
Publications
Anstee JE
(2023)
LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.
in Developmental cell