📣 Help Shape the Future of UKRI's Gateway to Research (GtR)

We're improving UKRI's Gateway to Research and are seeking your input! If you would be interested in being interviewed about the improvements we're making and to have your say about how we can make GtR more user-friendly, impactful, and effective for the Research and Innovation community, please email gateway@ukri.org.

Designing an intervention for snakebite prevention; a community-based participatory research approach

Lead Research Organisation: Liverpool School of Tropical Medicine
Department Name: Clinical Sciences

Abstract

Snakebite is extremely common in the rural areas of many tropical low-income countries. Many patients are bitten during cultivation of land, whilst herding livestock or when working in plantations. The rural location of most snakebites means that access to rapid care and treatment is very difficult and so outcomes are often poor. Prevention of snakebites in these populations is therefore crucial.

We plan to build on preliminary work in Eswatini to explore how effective prevention programmes could be developed in occupational settings. We will look at the risk factors for snakebite in a number of high-risk occupational settings (eg agricultural companies, mining) in Rwanda and Eswatini. These two countries have been chosen to enable us to look at a range of settings and different species of snake to help ensure that any solutions that we find can be used in other countries as well. Community members will be heavily involved in the project; we will undertake group discussions and key informant interviews with community members, people affected by snakebite, employers and community leaders about their perception of the prevention of snakebite and the factors they think predicts success or failure of interventions. In partnership with the community, we will then design a pilot prevention intervention will be developed and undergo a pilot evaluation. The final product will be a co-designed prevention intervention which is feasible and acceptable for use and can be tested for its effectiveness in a subsequent trial.

Technical Summary

Snakebite is extremely common in the rural areas of many tropical low-income countries. Many patients are bitten during cultivation of land, whilst herding livestock or when working in plantations. The rural location of most snakebites means that access to rapid care and treatment is very difficult and so outcomes are often poor. Prevention of snakebites in these populations is therefore crucial.
Taking a Community-Based Participatory Research approach we will develop a prevention programme which is scalable and sustainable. To develop such an intervention we will a) determine the groups that are most at risk from snakebite in occupational settings in Rwanda and Eswatini; b) use focus group discussions and key informant interviews with community members, people affected by snakebite, employers and community leaders to understand perception of the prevention of snakebite and the factors they perceive to predict success or failure of interventions and c) co-design a pilot-prevention intervention which will be developed and tested. Each step of the research will involve community members in the decision making. After the final adjustment, the project will have a prevention intervention, acceptable to the community and feasible for implementation which can subsequently be tested for its effectiveness in a trial.

Publications

10 25 50
 
Description Engagment with Industry partners in Eswatini and Rwanda to improve policy and practice for snakebite prevention
Geographic Reach Africa 
Policy Influence Type Contribution to new or improved professional practice
Impact This aspect of the work is in its early stages and hasn't been assessed as of yet. The provision of information pertaining to snakebite prevention has caused the companies to reevaluate their existing practices. We except the impact of this to continue in the coming months and years as the intervention/prevention work continues to be developed and implemented.
 
Description Collaboration with the University of Global Health Equity (UGHE) 
Organisation University of Global Health Equity
Country Rwanda 
Sector Academic/University 
PI Contribution LSTM is the lead on the MRC grant 'Designing an intervention for snakebite prevention; a community-based participatory research approach'. UGHE is conducting research to support the activities
Collaborator Contribution UGHE has overseen all field operations in Rwandaand has done significant work to raise awareness of snakebite in country
Impact UGHE is partnered with LSTM on multiple snakebite grants
Start Year 2023
 
Description Launch Meeting (Eswatini) - African Snakebite Alliance and MRC Prevention Discussion 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This meeting was held to launch the African Snakebite Alliance activities in Eswatini and identify key research priorities for snakebite from policymakers and community members. The MRC prevention work was featured heavily during the discussions with policymakers as an example of snakebite research.
Year(s) Of Engagement Activity 2024
 
Description Launch Meeting (Rwanda) - African Snakebite Alliance and MRC Prevention Discussion 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact This meeting was held to launch the African Snakebite Alliance activities in Rwanda and identify key research priorities for snakebite from policymakers and community members. The MRC prevention work was featured heavily during the discussions with policymakers as an example of snakebite research.

Two Focus Group Discussions were conducted in separate rooms at the same time. Participants were divided into policymakers (n=12) and community members (n=19).
Year(s) Of Engagement Activity 2024
 
Description Mini symposium: From Venom to Doctorate 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The mini-symposium was used to highlight snakebite to the general public and students. The MRC Prevention programme was discussed and used as an example during the session.
Year(s) Of Engagement Activity 2024
 
Description New Scientist Live Event (2024) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact CSRI Represented LSTM at the 2024 New Scientist Live Event in London. The event was used to showcase the scope of CSRI research and activities across all grant. Over the three days, our stall was visited by several hundred members of the public and school children (on school day) where we talked about snakebite, the range of research grants that CSRI currently has underway.
Year(s) Of Engagement Activity 2024
URL https://live.newscientist.com/
 
Description Recognition of grant by UK Minister Dobbs 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Wendy Morton asked a question to Secretary of State about NTD research.

• What steps he is taking to support UK research into neglected tropical diseases.
• What steps his Department is taking to use UK research capacity in neglected tropical diseases to support his policy objectives in this area.

Response (From Minister Dobbs instead):
"The Foreign, Commonwealth and Development Office (FCDO) is supporting the Drugs for Neglected Diseases initiative (DNDi), a Product Development Partnership that develops novel medicines for Neglected Tropical Diseases (NTDs). DNDi partners with over 40 academic partners in the UK for its vital research. In addition, the FCDO is in the process of finalising an agreement to support a UK academic institution with the development of novel health technologies for NTDs.
The FCDO also supports UK research capability via our partnership with the Medical Research Council (MRC). This includes research on NTDs led by the Liverpool School of Tropical Medicine on the design of a community-based intervention for snakebite prevention funded through the FCDO/MRC Concordat."
Year(s) Of Engagement Activity 2025