Molecular and ecological investigations into the infection process of Eurychasma dicksonii on brown algae

Lead Research Organisation: Scottish Association For Marine Science
Department Name: Scottish Association For Marine Science

Abstract

Many of the most devastating agricultural and aquacultural pathogens belong to the group of oomycetes. In addition, many oomycetes seriously impact upon the ecology of natural populations. In coastal marine ecosystems, the oomycete Eurychasma dicksonii is thought to contribute to shaping populations of brown algae. It not only has the largest reported host range among marine pathogens - infecting virtually every brown algal species tested so far, but it is also the most prevalent eukaryotic pathogen in natural brown macroalgal populations. Remarkably, virtually nothing is known about many fundamental aspects of pathogenicity, biology, epidemiology, and ecology of E. dicksonii. As part of the Oceans 2025 core strategic program, we are currently developing tools to study the impact of E. dicksonii epidemics on algal populations and coastal ecosystems. However, many unresolved biological questions are of critical importance to underpin this undertaking. Understanding why E. dicksonii has such a wide host-range, what makes this pathogen so successful, and what pathogenicity determinants and infection strategies it uses to infect its hosts will shed light on how natural brown algal populations are affected by epidemic outbreaks of E. dicksonii, and how this pathogen might influence their genetic structure. This application aims to address these issues in more detail. Identified determinants of host specificity will further be correlated to the genetic and biogeographical background of the pathogen from sites around the world. At the completion of this study, we expect to demonstrate that E. dicksonii is secreting effector molecules that may be translocated into the host cells, and that are under diversifying selection. We hope to generate precise hypotheses on their role in the biotrophic interaction of E. dicksonii with its hosts, as well as its impact on natural brown algal populations.

Publications

10 25 50
 
Description We have - for the first time ever in seaweeds - explored the transcriptome and proteome of the important brown algal model Ectocarpus during infection by the basal oomycete Eurychasma.
This has fundamental significance for a better understanding of infection and disease resistance in marine algae and other eukaryotes - including human pharmacology.
Exploitation Route Access to original publications (all Open Access); possibly development of marine natural products as pharmaceutical agents.
Sectors Agriculture, Food and Drink,Chemicals,Environment,Pharmaceuticals and Medical Biotechnology

 
Description Images from this research have been used by PI Gachon in collaboration with CRUBAG (Oban, Argyll) for artistic purposes in textile design.
First Year Of Impact 2014
Impact Types Cultural