In situ Lab on a chip chemical sensor technology

Lead Research Organisation: NATIONAL OCEANOGRAPHY CENTRE
Department Name: Science and Technology

Abstract

Researchers at the National Oceanography Centre, Southampton, and at the School of Electronics and Computer Science at the University of Southampton have collaborated to produce novel Lab-on-a-chip chemical sensors. These miniaturised devices use microfabrication techniques similar to those used to manufacture integrated circuits out of semiconductor materials. This enables very compact design. The devices contain fluid channels that enable seawater to be mixed with chemical reagents that produce a colour change (or fluorescence) with intensity proportional to the chemical content of the seawater. It is possible to change the reagent added to measure a number of chemicals that are important in the study of the environment. These include nutrients (such as phosphate) and pollutants. Whilst measurement systems based on this technique do exist, currently available technology is large, expensive, and difficult to operate. Miniaturisation enables cheaper more robust sensors that are easier to use and suitable for mass production. Our current prototype is the size of a 1.5l drinks bottle, but the next generation will be the size of a soft drinks can. The proposed activity will evaluate if this technology has commercial potential (i.e. can industry make money out of this) and will identify the first steps of a plan to maximise the income generated by this idea. This will include an evaluation of the market for the sensor technology; a review of patents and opportunities for protection of the idea; and evaluating possible partners and initiating contacts with them. Chemical sensing is required by a number of industries (e.g. agriculture, aquaculture , water treatment industries, offshore industries) and by scientists (e.g. in oceanography, in the study of fresh water systems, and in plant research). We are therefore, hopeful that this idea could have significant market potential and could contribute to the competitiveness of UK industry.
 
Description There is a significant and wide market for chemical sensors based on lab on chip technology. This has motivated considerable further R&D which through subsequent funding has resulted in devices now being commercialised.
Exploitation Route The results have motivated further R&D and innovation activity resulting in a patent (national phase) 1 license and a further evaluation agreement.
Sectors Aerospace, Defence and Marine,Chemicals,Electronics,Environment,Manufacturing, including Industrial Biotechology

 
Description The market survey enabled has motivated further R&D and commercialisation
First Year Of Impact 2012
Sector Aerospace, Defence and Marine,Chemicals,Electronics,Environment,Manufacturing, including Industrial Biotechology
Impact Types Societal,Economic

 
Description CEFAS lowestoft lab 
Organisation Centre For Environment, Fisheries And Aquaculture Science
Country United Kingdom 
Sector Public 
PI Contribution We collaborate with CEFAS Lowestoft on the development and application of new sensor technologies for their operational and research requirements. We provide sensors R&D, deliver sensors we have developed, as well as with operational support of demonstration deployments and operational data gathering campaigns.
Collaborator Contribution CEFAS Lowestoft provide access to operational infrastructure including instrumented buoys, autonomous vehicles and ships often with co-sampling that can be used to benchmark sensor performance which is essential for demonstrating sensor performance and value in an application. They also supply operational and scientific knowledge of applications enabling the technology to have enhanced impact into resource management and policy.
Impact Deployment of nutrient sensors on the RV Endevour and on Smart Bouys in the Thames and coastal sites
Start Year 2009
 
Title MICROFLUIDIC ABSORPTION CELL 
Description An absorption cell for microfluidic chemical analysis made from tinted or coloured polymers, for example polymethylmethacrylate (PMMA), in which microfluidic channels are cut. Light is coupled into the absorption cell via two windows (typically 200 um thick) that are retained at either end of the channel. Absorption is measured using a light source, such as a light emitting diode (LED) and a photodiode butted against the windows. Spurious scattered and/or reflected light is absorbed by the coloured polymer over the length of the measurement cell, while very little light loss occurs at the coupling windows. 
IP Reference WO2011095821 
Protection Patent granted
Year Protection Granted 2011
Licensed Yes
Impact License being drafted
 
Title MOLYBDENUM BLUE ASSAY FOR MEASUREMENT OF CHEMICAL SPECIES 
Description A process for measuring a concentration of a chemical species in an aqueous sample employing polyvinylpyrrolidone. The process comprises : providing an aqueous sample containing the chemical species; mixing the aqueous sample with a first reagent that comprises a solution of a molybdenum VI salt to provide a first solution; mixing the first solution with a second reagent that comprises a reducing agent to form a second solution; and measuring a property of the second solution to determine the concentration of the chemical species. Polyvinylpyrrolidone is added to the aqueous sample, the first reagent, the first solution or the second solution. The intensity of light absorbed or transmitted by the second solution may be used to determine the concentration of the chemical species. 
IP Reference WO2018087507 
Protection Patent application published
Year Protection Granted 2018
Licensed No
Impact Added to the body of IP offered in a currently running IP auction / partnering opportunity. The outcome of this is pending but will either result in a license to one of the 5 bidders, a joint venture (with one or more of the 5 bidders) or a spinout company (possibly in collaboration with one or more of the 5 bidders
 
Title Pump and valve 
Description New components of microfluidic analysers with improved performance i.e. valves and pumps 
IP Reference GB1619023.3 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact Added to the body of IP offered in a currently running IP auction / partnering opportunity. The outcome of this is pending but will either result in a license to one of the 5 bidders, a joint venture (with one or more of the 5 bidders) or a spinout company (possibly in collaboration with one or more of the 5 bidders
 
Title UV oxidation device 
Description A device for oxidation of samples prior to analysis by a chemical analyser 
IP Reference GB1619020.9 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact Added to the body of IP offered in a currently running IP auction / partnering opportunity. The outcome of this is pending but will either result in a license to one of the 5 bidders, a joint venture (with one or more of the 5 bidders) or a spinout company (possibly in collaboration with one or more of the 5 bidders)