Cracking the Code of Adaptive Evolution (deCODE)

Lead Research Organisation: University of Birmingham
Department Name: Sch of Biosciences

Abstract

Study systems are needed to definitively test and identify the mechanisms of adaptation to environmental change. Few animal models exist that enable surveys of their natural populations over hundreds or thousands of generations, which are needed to observe genetic fixation of adaptive responses. The extent to which epigenetic adaption precedes and informs genetic fixation is also unknown. Direct measurements of the rates of genetic and epigenetic evolution and associated fitness gains during an adaptation event will lead to improved understanding of the molecular targets of natural selection.
We aim to develop and exploit a massively multi-generational system where we can study the process of adaptation on scales ranging from molecules to phenotypes. Our purpose is to radically transform our understanding of how organisms and their populations cope with increasing stresses on ecosystems, by focusing biology's most modern tools towards discovering the molecular targets of natural selection and their contributions to the process of adaptation by phenotypic plasticity, epigenetics and conventional evolution. This knowledge will help policy makers and industry to refine their assessments of environmental health risks and prioritize actions that safeguard biodiversity and vital ecosystem services.
In scope with this NERC's call for "research that integrates ecological and evolutionary genetics", we will study the process of adaptation using a premier model species (Daphnia). Arguably, more is known about Daphnia's ecology than all other studied animals. They are keystone species in the food webs of aquatic ecosystems and early indicators of threats to ecosystem health and services. A large research community has established their importance as a model for ecological, toxicological and evolutionary research.
We propose to combine field and laboratory experiments to directly observe the processes of acclimation in physiological time scales (plasticity), with natural history experiments to directly observe genetic adaptation through evolutionary time (conventional evolution). Unique discoveries will be made because of Daphnia's parthenogenetic life cycle which alternates clonal and sexual reproduction. This allows for partitioning of phenotypic differences and changes in gene regulation (measured among individuals and populations) into genetic variation, environmental variation and gene-environment interactions for uncovering the molecular genetic and epigenetic basis of phenotypic plasticity. Few other model species produce dormant embryos as part of their life cycle, thereby archiving centuries of population genetic changes within dated lake sediments.
We will "resurrect" 100 Daphnia magna from a lake spanning 10 years of adaptation to hypereutrophication, then compete populations from periods that predate human interference to their more modern and adapted decedents. We will associate changes in their genomes, transcriptomes, epigenomes and metabolomes to the documented evolution of fitness related traits. Here we propose to uncover the regulatory pathways for the various modes of adaptation and directly test for a mechanistic link between phenotypic plasticity and the evolution of genetically fixed adaptive traits.
We will also infer the genetic basis for the regulatory pathways by discovering the quantitative trait loci that control variation in global mRNA and metabolic profiles for Daphnia including abundance and variance of expression. The segregating levels of variation at these loci will presumably reflect the capacity for populations to adapt and will provide a model to be validated by genome engineering.
Finally, we will advance the area of genome engineering (CRISPR) for research on the environment by experiments that will lead to predictive models of the limits of adaption in an ecologically essential species, and more generally, in metazoans that critically support the food chain of inland water ecosystems.

Planned Impact

deCODE is a research initiative that is genuinely motivated and focused on transforming environmental health protection. It is conceived by a newly formed (late 2012) and growing interdisciplinary "environmental genomics" research group at the University of Birmingham that has a purpose to deliver scientific leadership in the areas of environmental policy making, regulation and risk assessment, in the UK and abroad. Our approach is to use modern instruments for measuring structure and functional variation of genomes and metabolism of a superb model species (Daphnia) in evolutionary ecology and toxicology, to purposefully contribute mechanistic knowledge that is required to understand and help reduce uncertainty in managing a global and complex environmental health crisis.
Freshwater ecosystems have been described as the most endangered ecosystems in the world. Anthropogenic activities and pollution over the last two centuries have significantly altered the functioning of aquatic ecosystems and their resilience to change. Decision makers are besieged by a significant gap in knowledge required to take effective regulatory actions that protect natural resources and the lives of UK citizens while also safeguarding the UK economy from over-regulation that impacts people's livelihood. Such a delicate balance can only be reached by decisions that are informed by knowing how adaptive processes are controlled and evolve.

Who will benefit from deCODE (outside of related academics)? Policy and decision makers in the UK and EU will benefit most from the outcome of this research. Europe has taken extraordinary legislative steps to protect its natural resources, including the Water Framework Directive (WFD), which is meant to achieve "good ecological status" for all waters on the continent by a set deadline. Yet unlike the REACH legislation (Registration, Evaluation, Authorisation & Restriction of Chemicals) - which has broadened the types of scientific evidence deemed to be useful for safety assessment and has therefore spurred a renaissance for the field of predictive toxicology now focused on discovering response mechanisms that lead to adversity - hazard assessment for ecosystems is still based on prescribed ecotoxicity testing. A mechanistically based approach is required in order to predict the tipping points at which populations reach their buffering capacity limits at coping with environmental change. We are actively collaborating with scientists at the JRC, Ispra, who are integral to the development of science-based policy for freshwater environmental protection in the UK and Europe. These scientists in the Institute for Environment and Sustainability will directly and significantly benefit from this research. Furthermore we are actively engaged (through existing NERC funding) with UK Environment Agency scientists, who will also benefit.

How will they benefit? Our research is designed to support WFD policy, by choosing to study response mechanisms of adaptation in a required test species for regulation (Daphnia included with an algal and a fish species). Moreover, our entire research project is about connecting signatures of population resilience to an urgent and specific environmental problem - hypereutrophication and the quality of freshwater supporting ecosystem services. Insights obtained from this model system have intrinsic value: freshwater ecosystems costs England and Wales over 220M EUR per year and the EU over 2B EUR per year. Our existing collaborations will enable dialogue and the input of this NERC funded science into both UK (via Environment Agency) and European (via JRC) regulatory science. We will begin to develop a brand new knowledge base and set of tools that will directly inform within immediate time-scales the development of policy and mitigation measures.

Publications

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Brockmeier EK (2017) The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment. in Toxicological sciences : an official journal of the Society of Toxicology

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Cuenca Cambronero M (2018) Haemoglobin-mediated response to hyper-thermal stress in the keystone species . in Evolutionary applications

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Cuenca Cambronero M (2018) Resurrection of Dormant Daphnia magna: Protocol and Applications. in Journal of visualized experiments : JoVE

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Cuenca Cambronero M (2018) Evolution of thermal tolerance in multifarious environments. in Molecular ecology

 
Description Chair, Institute for Advanced Studies Workshop Environment Care - Mapping the Chemosphere
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Chair, International Environment Care Consortium Meeting, Hebei University, Baoding, China
Geographic Reach Asia 
Policy Influence Type Influenced training of practitioners or researchers
Impact This meeting of the Environment Care Consortium assembled researchers, legal experts, public health practitioners and governance experts including NGOs from the UK, China, India, Bangladesh and the USA to plan for a major investment by the Hebei Province in China of 20 million pound towards the establishment of the The International Center for Precision Environmental Health and Governance.
URL https://www.birmingham.ac.uk/news/latest/2018/10/universities-plan-joint-institute.aspx
 
Description Contract training for the European Chemicals Agency on Omics applied to regulation
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Professors Mark Viant and John Colbourne are contracted to provide a series 1.5-day long education and training of regulators at the European Chemicals Agency on the use of Omics and model species for testing the potential environment and human health risks of chemicals.
 
Description Contract training for the European Chemicals Agency on Omics applied to regulation
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Professors Mark Viant and John Colbourne are contracted to provide a series 1.5-day long education and training of regulators at the European Chemicals Agency on the use of Omics and model species for testing the potential environment and human health risks of chemicals.
 
Description Invited Expert for Defra UK and Japan Environment Ministry workshop on endocrine disrupting chemicals
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Invited Expert, Accelerating the Pace of Chemical Risk Assessment Workshop, UK / US / Japan / Canada Chemical Regulators
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
 
Description Invited Expert, Omics in risk assessment: state-of-the-art and next steps, European Food Safety Authority (EFSA), Berlin, Germany
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
Impact A Summary Report was published on this 24th EFSA colloquium on "OMICS in risk assessment: state-of-the-art and next steps".
 
Description Invited Expert, Towards Precision Toxicology, European Union Directorate General Joint Research Centre, Italy
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Invited Expert: Future of UK Environmental Health Protection for Defra, Public Health England, Health Safety Executive & Environment Agency
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Invited Expert: International workshop on advanced chemical safety assessment technologies
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Professor John Colbourne was invited to the Joint Meeting of Analytical Toxicology and Computational Toxicology Committee (Chinese Society of Toxicology) and International Workshop on Advanced Chemical Safety Assessment Technologies to provide guidance on the establishment of a new Society for Computational and Systems Toxicology and to align Chinese interests in environmental health protection research with those of the international Environment Care Consortium, which University of Birmingham leads.
 
Description NERC: Chemicals in the environment scoping workshop
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Professor John Colbourne participated in a workshop aimed to identify the key environmental research priorities needed to underpin management of chemicals in the environment relevant to the UK, with a view to potentially developing new collaborative research activity. The workshop assembled experts from Government policy and regulation, industry, civil society and environmental science perspectives to: • scope priority challenges in chemicals management with regards to the natural environment • identify emerging research questions and opportunities to apply new techniques and approaches to address the issues, considering novelty and timeliness • determine approaches and partnerships needed to effectively translate research into practice e.g. enable risk-based decision making and uptake into policy measures • determine future UK research capacity needed to support management of chemical impacts in the natural environment
 
Description NERC: Short course in Environmentmental Omics
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact A NERC funded short course to guide genomics and metabolomics research applied to environmental sciences. This annual training course highlights a multi-omics (system biology) approach to research in environmental sciences. It trains PhD students and early career postdoctoral scientists to investigate how gene function and metabolism are influenced by environmental conditions while accounting for variation that exists within and among natural populations. The course is built on the paradigm that this multidisciplinary research field encompassing ecology, evolution, toxicology, biostatistics and informatics will most effectively grow by training early career environmental scientists to properly design comprehensive, large-scale, Next Generation Sequencing and Metabolomics experiments enabled by drastically increased sample-throughput and lower costs. Most importantly, the challenges of manipulating and analysing population-level omics (big) data must be addressed. The course provided a significant introduction and much hands-on training experience so that participants can initiate their own environmental omics study and network with others in the field to launch Environmental Scientist careers in academia and industry. Case studies using multi-omics data sets collected at the University of Birmingham are provided so that students can gain practical experience of analysing and integrating multi-omics data. Daphnia is used for training because of its growing use as a model system in the environmental sciences and for improving environmental health protection, yet the skills learned during the course are applicable to all study systems with mature genomics and metabolomics resources.
 
Description OECD Extended Advisory Group for Molecular Screening and Toxicogenomics
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL http://www.oecd.org/chemicalsafety/testing/toxicogenomics.htm
 
Description Science Advisory Board, Centre for Biodiversity Genomics
Geographic Reach North America 
Policy Influence Type Participation in a advisory committee
 
Description Scientific Reviewer for CSIRO Future Science Platform proposals
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Professor John Colbourne was invited to advise on a new intramural research program for the Commonwealth Scientific and Industrial Research Organisation. CSIRO is the federal government agency for scientific research in Australia. Its chief role is to improve the economic and social performance of industry, for the benefit of the community.
 
Description Alan Turing Fellowship
Amount £162,577 (GBP)
Organisation Alan Turing Institute 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 10/2021
 
Description BRIDGE: Seed Fund for collaboration between the University of Birmingham and the University of Illinois at Urbana Champaign
Amount £25,000 (GBP)
Organisation University of Birmingham 
Sector Academic/University
Country United Kingdom
Start 05/2016 
End 04/2017
 
Description CASE: Novel approaches to characterise the exposome: Enabling discovery of associations between pollutants and environmental health
Amount £96,776 (GBP)
Funding ID NE/N008820/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2020
 
Description Daphne water solutions for the removal of emerging pollutants from wastewater: market assessment and technical feasibility
Amount £8,325 (GBP)
Funding ID NE/S015515/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 01/2019 
End 07/2019
 
Description GLOBAL CHALLENGE RESEARCH FUND (Gnatwork), Validating Nanopore Sequencing Technology for Front-Line Pathogen-Vector Complex Studies,
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 03/2019 
End 02/2020
 
Description Genetic Factors that Influence Arsenic Toxicity
Amount $876,998 (USD)
Organisation National Institute of Environmental Health Sciences 
Sector Public
Country United States
Start 11/2018 
End 11/2023
 
Description Integrating metabolomics and physiological modelling to ensure food safety, BBSRC iCASE with UK Health & Safety Laboratory
Amount £7,400 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description International Collaboration Awards for Research Professors
Amount £369,000 (GBP)
Funding ID IC160121 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2016 
End 11/2021
 
Description MetaboFlow - the development of standardised workflows for processing metabolomics data to aid reproducible data sharing and big data initiatives
Amount £959,027 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description MetaboFlow - the development of standardised workflows for processing metabolomics data to aid reproducible data sharing and big data initiatives
Amount £190,915 (GBP)
Funding ID 202952/C/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 09/2020
 
Description Next generation tools for the annotation of metabolites in global LC-MS metabolomic studies
Amount £113,285 (GBP)
Funding ID BB/N023013/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2017
 
Description Probing the metabolic response of induced diapause in the crustacean Daphnia
Amount £35,000 (GBP)
Funding ID 2016-2017-NBAF973 
Organisation Natural Environment Research Council 
Department NERC Biomolecular Analysis Facility (NBAF)
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2017
 
Description Quantifying community metabolomes within model freshwater ecosystems and their responses to pollutants, NERC iCASE and Thermo Fisher Scientific
Amount £100,000 (GBP)
Funding ID NE/R008191/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start  
 
Description UK Consortium for MetAbolic Phenotyping (MAP UK)
Amount £2,138,276 (GBP)
Funding ID MR/S010483/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2019 
End 05/2023
 
Description Ultrahigh sensitivity metabolomics: opening a window into the metabolic evolution of a sentinel invertebrate through the industrial revolution
Amount £98,292 (GBP)
Funding ID 1935325 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start  
 
Description Validation of in silico predictions of metabolic changes in the waterflea Daphnia exposed to abiotic stress
Amount £37,300 (GBP)
Funding ID 2016-2017-NBAF974 
Organisation Natural Environment Research Council 
Department NERC Biomolecular Analysis Facility (NBAF)
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2017
 
Description Birmingham and Hebei Universities plan joint environmental health and justice research institute 
Organisation Hebei University
Country China 
Sector Academic/University 
PI Contribution The University of Birmingham and Hebei University have signed an agreement to set up a joint research institute that will help to tackle major global problems linked to environmental pollution and injustice. Our team had worked over three years to create this opportunity, from funds provided by the Hebei Province of China.
Collaborator Contribution The institute will combine science and social science research - for example, setting the global policy agenda by combining understanding of how individuals and economy respond to environmental policy with scientific research identifying problems and how they might be solved. The Institute will focus on investigating solutions to a range of issues, namely: pollution from multiple sources; public health crises caused by environmental toxicity concentrated among the poorest and most vulnerable populations; and the failure of regulatory efforts to tackle these issues. The Institute brings together scientists, lawyers, engineers and health experts in Baoding, Hebei Province, located near China's Xiong'an New District, to create a hub for the international Environment Care Consortium, for postgraduate education and for research training, pursuing research funding opportunities in China and the UK and speeding up the development of new and sustainable industries in both countries.
Impact The International Center for Precision Environmental Health and Governance is still under development. Professor John Colbourne has accepted a Guest Professorship at Hebei University to continue to build momentum around this opportunity.
Start Year 2018
 
Description Environment Care Foundation 
Organisation Mount Desert Island Biological Laboratory
Country United States 
Sector Charity/Non Profit 
PI Contribution The Environment Care Consortium is a grassroots collaboration of researchers and professionals from over fifty institutions in twelve countries that grew since 2012 with the primary purpose of advancing our understanding of, and response to, toxic substances in our environment. The ECC is led by University of Birmingham backed by Indiana University and Mount Desert Island Biological Laboratory, USA. Its mission statement commits "to offer leadership at making the environment safe from chemicals and to defend people's rights to a healthful environment". The consortium's work is to apply action research that combines international partnerships with advances in science and law to understand the chemicals around us and lead the way in stopping them from causing harm to both humans and ecosystems.
Collaborator Contribution Together we have created a Foundation that is headquartered in Maine USA for the purpose of attracting charitable donations to solve pollution, primarily in key low and middle income countries such as Madagascar.
Impact The John D. and Catherine T. MacArthur Foundation named our project, to improve health in Madagascar, as one of the highest-scoring proposals (designated as the Top 100) in its 100&Change competition for a $100 million grant to help solve one of the world's most critical social challenges. Our Environment Care Consortium joins Indiana University with Pure Earth and other partners forming the Solve Pollution Network. By having received this recognition, our project is now featured in the Foundation's Lever for Change Bold Solutions Network, designed to unlock significant philanthropic capital by helping donors find and fund vetted, high-impact opportunities to improve people's lives. So far, MacArthur has raised an additional $419 million to support bold solutions.
Start Year 2019
 
Description A Roadmap for Precision Environmental Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Policymakers/politicians
Results and Impact A Roadmap for Precision Environmental Health, September 3, 2018. National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Year(s) Of Engagement Activity 2018
 
Description "Ecological seminar and discussion Series: Science Chat" at Bremen University (Germany) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Graduate student presented the talk "Bringing back one hundred years of evolution in one afternoon" to an audience made-up of researchers from multiple departments at the University of Bremen, on 19th November 2018.
Year(s) Of Engagement Activity 2018
 
Description 13th Annual Arthropod Genomics Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote address:
12th Annual Arthropod Genomics Symposium, June 12-14, 2019, Kansas city, State University, USA
Year(s) Of Engagement Activity 2019
URL https://www.k-state.edu/agc/ags/index.html
 
Description 16th Congress of the European Society for Evolutionary Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Graduate student presented the talk: "Forecasting species persistence to future global change by learning from past evolutionary dynamics"
The European Society for Evolutionary Biology (ESEB) 16th Congress was organized by the European Society for Evolutionary Biology (ESEB) and was held during Aug 20 - 25, 2017 at MartiniPlaza, Groningen, Groningen, Netherlands.
Year(s) Of Engagement Activity 2017
URL https://www.emedevents.com/c/medical-conferences-2017/european-society-for-evolutionary-biology-eseb...
 
Description 20th Congress of the Iberian Association of Limnology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote address:
20th Congress of the Iberian Association of Limnology (AIL-2020) and III Ibero-American Congress of Limnology (CIL-2020). 22nd-26th June, 2020, Murcia, Spain
Year(s) Of Engagement Activity 2020
 
Description 22nd European Meeting of PhD students in Evolutionary Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A graduate student presented the talk: "Forecasting species persistence to future Global Change" in Gotland. Sweden on 11-15/09/2016
.
Year(s) Of Engagement Activity 2016
 
Description 4th International Symposium of the Spanish researchers UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A graduate student presented the poster: "Past, present and future: the evolutionary cost of hyper-eutrophication" in London on 9-10/7/2016.
Year(s) Of Engagement Activity 2016
 
Description 51st Populations Genetics Group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The formal talk was delivered by a graduate student: "Evolution of thermal tolerance in multifarious environments over five decades of Global Change"
The Population Genetics Group (Popgroup) meets annually and is hosted at alternating locations throughout the UK. The meeting name was established in the 1960s, but today's topics include most areas of evolutionary genetics and genomics.
Year(s) Of Engagement Activity 2018
URL http://www.genetics.org.uk/events/pop-group/
 
Description 5th International Symposium of the Spanish researchers in UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A Spanish national graduate student presented the following talk: Talk: "Climate Change on aquatic ecosystems" in London on 7-9/07/2017
Year(s) Of Engagement Activity 2017
 
Description Back to the future with the evolutionary time machine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Keynote address:
Back to the future with the evolutionary time machine. World Water Day: water for all, 22nd of March 2019, Birmingham, UK
Year(s) Of Engagement Activity 2019
 
Description Biosciences Graduate Research School Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A graduate student presented the talk: Studying the effect of anthropogenic stress on aquatic ecosystem
70 students attended this annual symposium at our School of Biosciences.
Year(s) Of Engagement Activity 2017
 
Description CIMA/CMRA Epigenetics Meeting: Daphnia, a versatile model for understanding epigenetic control 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Leda Mirbahai was invited to inform on the biological attributes of Daphnia for epigenomics research.
Year(s) Of Engagement Activity 2016
 
Description CSIR-Indian Institute of Toxicity Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International Toxicity Conclave, CSIR-Indian Institute of Toxicity Research, Lucknow, India
Year(s) Of Engagement Activity 2017
 
Description Chinese Academy of Science: Workshop for environmental research collaboration 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Discussions focused on identifying a joint project, tied to a significant environmental problem that would benefit from the combined research interests and expertise of UoB and CAS. Following on from a recently awarded Royal Society International Collaboration award to Professors John Colbourne and Liang-Hong Ghuo to examine the utility of biomolecular signatures to monitor, diagnose and assure water quality in the Qiantang-Hangzhou Coastal-Megacity Watershed, we decided to coordinate an interdisciplinary research project for safeguarding a natural watershed and environment-sensitive economy that 20 millions people depend upon.
Year(s) Of Engagement Activity 2017
 
Description Contaminants in the San Francisco Bay-Delta: Novel Tools and Approaches to Evaluate Effects of Multiple Stressors 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Professor's John Colbourne and Ben Brown were invited to participate at this sponsored event by the Delta Stewardship Council (Delta Science Program), UC Davis Coastal and Marine Sciences Institute (CMSI) and the California State Water Resources Control Board (SWRCB). This day-long symposium aimed to inform scientists and managers on the status of effect-based novel tools and approaches developed for toxicological studies, and how their use can be integrated to evaluate impacts of multiple stressors on the San Francisco-Bay Delta ecosystem.
Year(s) Of Engagement Activity 2017
 
Description Cracking the code of past biodiversity responses to climate change 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact August 2018: Media coverage for the review article on Cracking the code of past biodiversity responses to climate change, Trends in Ecology and Evolution (https://www.birmingham.ac.uk/news/latest/2018/08/animals-and-plants-react-to-climate-change-study.aspx; https://www.science.ku.dk/english/press/news/2018/adapt-move-or-die-how-biodiversity-reacted-to-past-climate-change/).
Year(s) Of Engagement Activity 2018
URL https://www.birmingham.ac.uk/news/latest/2018/08/animals-and-plants-react-to-climate-change-study.as...
 
Description ESEB2018, II Joint Congress on Evolutionary Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Orsini, L. The role of genome structural variation on plastic and constitutive phenotypic divergence in multifarious environments. Symposium 'The role of genomic structural variants in adaptation and diversification', ESEB2018, II Joint Congress on Evolutionary Biology - Montpellier, France.
Year(s) Of Engagement Activity 2018
 
Description Environmental and (eco)toxicological omics and epigenetics meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Leda Mirbahai co-organized and co-chaired this focused joint meeting between the Society of Environmental Toxicology and Chemistry (SETAC) and the UK Environmental Omics Synthesis Centre (iEOS). The meeting results in a review paper on the topic to be published in the society professional scientific publication.
Year(s) Of Engagement Activity 2016
 
Description Gordon Research Conference in Cellular and Molecular Mechanisms of Toxicity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker, Gordon Research Conference in Cellular & Molecular Mechanisms of Toxicity, USA
Year(s) Of Engagement Activity 2017
 
Description II Joint Congress on Evolutionary Biology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The following talk was delivered by a graduate student: "Adaptive responses to Global Warming over five decades of evolution"
Joint Congresses take place every six years and bring together four of the world's largest academic societies in the field of evolutionary biology: the European Society for Evolutionary Biology, the American Society of Naturalists, the Society for the Study of Evolution and the Society of Systematic Biologists.
Year(s) Of Engagement Activity 2018
URL https://www.evolutionmontpellier2018.org/
 
Description II Joint Congress on Evolutionary Biology (2) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Luisa Orsini presented the talk: "The role of genomic structural variants in adaptation and diversification". Joint Congresses take place every six years and bring together four of the world's largest academic societies in the field of evolutionary biology: the European Society for Evolutionary Biology, the American Society of Naturalists, the Society for the Study of Evolution and the Society of Systematic Biologists.
Year(s) Of Engagement Activity 2018
URL https://www.evolutionmontpellier2018.org/
 
Description International day of Woman in Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A graduate student presented and discussed her experience as a woman in science at local primary schools in Spain, in celebration of International day of Woman in Science on 12th February 2019.
Year(s) Of Engagement Activity 2019
URL http://ceipalfares.blogspot.com/2019/02/dia-de-la-mujer-y-la-nina-en-la-ciencia.html
 
Description Interview: Inspiring women in science 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact In March 2019, Dr Orsini was interviewed in occasion of the Woman day - social media coverage 'Inspiring women in science'
Year(s) Of Engagement Activity 2019
 
Description Interview: World Water Day, Water for all 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact In February 2019, Dr Orsini was interviewed in occasion of the World Water Day-Water for all organized by the Birmingham Water Council to increase awareness about water challenges https://youtu.be/A9gnFOGCSQ4. The interview has to this day had 419 views.
Year(s) Of Engagement Activity 2019
URL https://youtu.be/A9gnFOGCSQ4
 
Description Invited Seminar at the Biological Station of Doñana (CSIC). Seville, Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact A graduate student presented the invited talk: "Bringing back one hundred years of evolution in one afternoon" on 15th November 2018.
Year(s) Of Engagement Activity 2018
 
Description Milner Centre for Evolution, University of Bath, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Dr Luisa Orsini presents invited talk "Back to the future with the evolutionary time machine" for a departmental seminar at University of Bath, UK.
Year(s) Of Engagement Activity 2019
 
Description OpenTox Asia 2017 Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact OpenTox Asia 2017 Conference. Daejeon, Korea.
Year(s) Of Engagement Activity 2017
 
Description Research Event: Birmingham Strikes Back 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact In November 2019 the Star Wars Research Event - "Birmingham Strikes Back" organized by the University of Birmingham in which Dr Orsini was an invited speaker reached 11,000 views, 193 comments and 32 shares. The science podcast and the lecture described the process of long-term evolution using Daphnia as a model species, using parallels to Han Solo frozen in carbonite. If you missed #birminghamstrikesback, you can view it again on the UoB Facebook channel https://facebook.com/unibirmingham/); https://www.facebook.com/unibirmingham/videos/2507829439303910.
Year(s) Of Engagement Activity 2019
URL https://www.birmingham.ac.uk/university/colleges/socsci/events/future-fest/events/birmingham-strikes...
 
Description Roadmap to Environmental Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote "Roadmap to Environmental Health", 10th Nat. Conf. on Env. Chemistry, Tianjin, China
Year(s) Of Engagement Activity 2019
 
Description Ruhr-Universität Bochum: Daphnia model system for environmental genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Professor John Colbourne was invited to present a departmental seminar.
Year(s) Of Engagement Activity 2017
 
Description Slightly Evolved, a weekly science podcast for science outreach 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Dr Luisa Orsini was interviewed for a 45 minute podcast on Swedish podcast "Slightly Evolved".
Year(s) Of Engagement Activity 2018
URL https://soundcloud.com/slightlyevolvedpod
 
Description The evolutionary time machine unravels the mechanisms of contemporary evolution 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote address:
The evolutionary time machine unravels the mechanisms of contemporary evolution. Society of Molecular Biology and Evolution (SMBE) 2019, Contemporary Evolution symposium. 21-25 July, 2019, Manchester, UK
Year(s) Of Engagement Activity 2019
 
Description Toxicity by descent: a modern chemical hazard assessment framework 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Toxicity by descent: a modern chemical hazard assessment framework, November 6, 2019. SETAC North American Annual Meeting, Toronto, Canada.
Year(s) Of Engagement Activity 2019
 
Description U.S. Department of Energy Joint Genome Institute, California USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dr Luisa Orsini presented an invited seminar attended by scientists at the Joint Genome Center, the Lawrence Berkeley National Laboratory and the University of California, Berkeley.
Year(s) Of Engagement Activity 2018
 
Description University College London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Centre for Biodiversity and Environment Research, University College London, London, UK
Year(s) Of Engagement Activity 2017
 
Description University of Leicester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Orsini, L. Evolutionary time traveling: resurrecting the past to deal with the future. University of Leicester. 22nd March 2017
Year(s) Of Engagement Activity 2017
 
Description University of Lund 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Orsini, L. Evolutionary time traveling reveals 'ecological surprises' to global change response in the wild. University of Lund, Denmark. 22nf of February 2018
Year(s) Of Engagement Activity 2018
 
Description University of Lund, Sweden 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Dr Luisa Orsini presented an invited seminar: "Evolutionary time traveling reveals 'ecological surprises' to global change response in the wild"
Year(s) Of Engagement Activity 2018
 
Description Visit by Professor GUO Jian, Hebei University Party Secretary, China 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Third sector organisations
Results and Impact Visit towards a China-UK Partnership for Environmental Research
Year(s) Of Engagement Activity 2017
 
Description World Water Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact University of Birmingham is hosting an international event to bring attention to the water science related expertise in Birmingham. Luisa Orsini leads the School of Biosciences team partly because of the advances being made with deCODE.
Year(s) Of Engagement Activity 2019
URL https://www.birmingham.ac.uk/research/activity/water-sciences/world-water-day/index.aspx
 
Description World Water Day - Water for all 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Dr Luisa Orsini was interview for media campaign to bring awareness to water resource issues, organized by the Birmingham Water Council.
Year(s) Of Engagement Activity 2019