ProSPECTuS: Preclinical Trials

Lead Research Organisation: University of Liverpool
Department Name: Physics

Abstract

Single Photon Emission Computed Tomography (SPECT) is a widely used imaging modality in medicine which uses radio-pharmaceuticals labelled with gamma emitting radioisotopes. Existing SPECT systems have a limiting position resolution of about 10 mm for body imaging and 7 mm for the head. The proposed system will offer an image resolution of 2-3 mm with a sensitivity a factor of ~100 larger than existing systems, while simultaneously enabling SPECT/MRI multimodality imaging. The ProSPECTus imager will open existing markets worth in excess of £300M pa to UK companies, covering medical, pharmaceutical, homeland security, science and defence. The consortium brings an internationally leading reputation and many years experience with semiconductor radiation detectors, electronics and software design. Key clinical input and trials are provided through Clinicians at the Clatterbridge Centre for Oncology , the University of Liverpool Magnetic Resonance Imaging Analysis Research Centre [MARIARC] and the Interventional Radiology and Medical Imaging Group at the Royal Liverpool University NHS Trust.

Publications

10 25 50
publication icon
Harkness L (2013) Characterisation of a Si(Li) orthogonal-strip detector in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

publication icon
Harkness L (2012) Semiconductor detectors for Compton imaging in nuclear medicine in Journal of Instrumentation

publication icon
Harkness L (2012) A Compton camera application for the GAMOS GEANT4-based framework in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

 
Description A new state-of-the art SPECT/MR demonstrator has been realised. Pre-clinical trials indicate that the performance of the system is a factor 10 more sensitive then ext siting clinical SPECT cameras.
Exploitation Route The next phase of the project will lead to clinical trials. This will be in collaboration with a small OEM and a clinical partner.
Sectors Healthcare

 
Description A new state-of-the art SPECT/MR demonstrator has been realised. Pre-clinical trials indicate that the performance of the system is a factor 10 more sensitive then ext siting clinical SPECT cameras.
First Year Of Impact 2014
Sector Healthcare
Impact Types Cultural,Economic

 
Title New image reconstruction methodology 
Description A new 3D image fusion reconstruction metrology has been developed for real time 3D Compton gamma-ray imaging. 
Type Of Material Technology assay or reagent 
Year Produced 2014 
Provided To Others? Yes  
Impact Significant improvement in image resolution and over ally system sensitivity 
 
Description Proton Therapy 
Organisation The Clatterbridge Cancer Centre NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Access to the Proton Therapy facility for measurements with phantoms.
Collaborator Contribution Extensive clinical knowledge and experience.
Impact The research work is in progress
Start Year 2015
 
Title SPECT/MR Compton imager 
Description A new SPECT/MR camera 
Type Diagnostic Tool - Imaging
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2014
Development Status Under active development/distribution
Impact Potential for short scan time with SPECT or reduced dose to patient 
 
Title Compton Imaging algorithms 
Description Novel Compton Imaging algorithms to reconstruct 3D image data 
Type Of Technology Software 
Year Produced 2014 
Impact Improvements in image quality/sensitivity and fusion 
 
Title Pulse Shape Analysis algorithms 
Description Signal decomposition algorithms for large volume semiconductor detectors 
Type Of Technology Software 
Year Produced 2014 
Open Source License? Yes  
Impact Precise and accurate position determination with a large volume detector offers huge improvements in the subsequent processing of the signal data 
 
Description Advances in semiconductor sensors, Gamma-ray imaging systems, South Dakota, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact International conference on germanium detector systems.
Year(s) Of Engagement Activity 2014
 
Description Imaging 2016 conference presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Imaging 2016 international conference in Stockholm, Sweden. Showcasing the impact of STFC technology in Medical Imaging.
Year(s) Of Engagement Activity 2016
 
Description Physics INNOVATE 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Physics INNOVATE was run as part of the international festival of business. Held in Liverpool at the Convention Centre (2016) and the Town Hall (2015). The event showcased the key UoL and STFC technologies to a broad range of industry. A number of new projects have commenced following these events.
Year(s) Of Engagement Activity 2015,2016