Sub voxel position identification in Cadmium Zinc Telluride detectors for Low Dose Molecular Breast Imaging

Lead Research Organisation: University of Liverpool
Department Name: Physics

Abstract

This knowledge exchange project seeks to develop an optimised Cadmium Zinc Telluride (CZT) system for low dose molecular breast imaging (MBI). Breast cancer is the most common type of cancer in the UK, with 1 in 8 women developing the disease. Approximately 50% of women of screening age have mammographically dense breasts but conventional X-ray mammography has reduced diagnostic performance for these patients. This limitation can be overcome by using MBI, a technique in which a molecular tracer selectively targets malignant breast tissue to provide high-resolution functional images. Earlier diagnosis and more accurate staging of the disease using optimised MBI systems will potentially lead to better patient outcomes and reduced mortality rates. The proposed research will improve the imaging performance of MBI, which will increase the probability of detecting lesions in the breast. This will be based on exploiting our knowledge of how radiation interacts in the imaging system.

Publications

10 25 50
 
Description Sub-voxel position identification in Cadmium Zinc Telluride detectors for Low Dose Molecular Breast Imaging
Amount £545,073 (GBP)
Funding ID 2112967 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 03/2022
 
Description The Tale of Two Tunnels
Amount £77,545 (GBP)
Funding ID ST/S000127/1 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 04/2020
 
Title CZT signal database 
Description Experimental database for charge signals inside a pixellated CZT detector, acquired using collimated gamma-ray sources. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? No  
Impact Not known 
 
Description eV Products (Kromek USA) 
Organisation eV Products, Inc
Country United States 
Sector Private 
PI Contribution A PhD student from the project team went to eV products in USA for 3 weeks to conduct NEMA tests of a CZT SPECT system.
Collaborator Contribution The partners financed the cost of the student visit, including hotel and travel. They also provide supervision and we are continuing to analyse the results following the visit.
Impact The results are currently under analysis. It is expected they will be publishable. The student also developed new skills.
Start Year 2016
 
Description Seminar to undergraduate students at University of West Scotland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Seminar on the development of DEPICT for dose verification of radionuclide therapy. The audience was mainly undergraduate students, none of whom are from my institution. There was an increase in interest in medical applications of nuclear physics and a number of students asked for more information and to read my publications and book.
Year(s) Of Engagement Activity 2019
 
Description Talk at STFC Knowledge Exchange Event "Collaborating with industry and the NHS to develop next generation medical imaging systems" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Talk at a knowledge exchange event to showcase how research projects have been developed in collaboration with the NHS and radiation detector industry. Discussed timescales and advised on challenges faced, to encourage other multidisciplinary activities.
Year(s) Of Engagement Activity 2019