Investigating the mechanism of action of small-molecule modulators at the human CXCR2 receptor

Lead Research Organisation: University of Nottingham
Department Name: School of Life Sciences

Abstract

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Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M008770/1 30/09/2015 31/03/2024
1944745 Studentship BB/M008770/1 30/09/2017 25/11/2021
NE/W503162/1 13/04/2021 12/04/2022
1944745 Studentship NE/W503162/1 30/09/2017 25/11/2021
 
Description Small molecules acting as antagonists of the human CXCR2 receptor were investigated in their ability to inhibit receptor activation and fluorescent endogenous agonist binding to the receptor. All molecules tested inhibited CXCR2 activation but they displayed different pharmacological profiles which may be underlined by differences in their receptor residence time.
Exploitation Route Extention of funding to complete the project
Sectors Pharmaceuticals and Medical Biotechnology