Investigating the mechanism of action of small-molecule modulators at the human CXCR2 receptor
Lead Research Organisation:
University of Nottingham
Department Name: School of Life Sciences
Abstract
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Organisations
People |
ORCID iD |
| Nicholas Holliday (Primary Supervisor) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M008770/1 | 30/09/2015 | 31/03/2024 | |||
| 1944745 | Studentship | BB/M008770/1 | 30/09/2017 | 25/11/2021 | |
| NE/W503162/1 | 13/04/2021 | 12/04/2022 | |||
| 1944745 | Studentship | NE/W503162/1 | 30/09/2017 | 25/11/2021 |
| Description | Small molecules acting as antagonists of the human CXCR2 receptor were investigated in their ability to inhibit receptor activation and fluorescent endogenous agonist binding to the receptor. All molecules tested inhibited CXCR2 activation but they displayed different pharmacological profiles which may be underlined by differences in their receptor residence time. |
| Exploitation Route | Extention of funding to complete the project |
| Sectors | Pharmaceuticals and Medical Biotechnology |