Novel Electron Transfer and Electrosynthetic Approaches to Opiate Analgesics
Lead Research Organisation:
Imperial College London
Department Name: Dept of Chemistry
Abstract
The proposed research involves an ambitious programme that blends pure synthesis with the advancement of new free radical methodology and electrochemical flow applications in modern synthesis and also the development of original synthetic applications. In this outline proposal we aim to discover novel agents for the treatment and cure of Alzheimer's disease and other dementias, ranking the impact of this project at high social and national importance, since the expected turnover for this discovery is expected to be in the $M as the cost of treating dementia sufferers is expected to reach $16.7B per annum by 2017. It is predicted that this work will be highly patentable.
People |
ORCID iD |
| Philip Parsons (Primary Supervisor) | |
| Philipp Natho (Student) |
Publications
Natho P
(2020)
Recent advances in the ring expansion of cyclobutanols, oxetanols, and azetidinols
in Tetrahedron Letters
Natho P
(2019)
Transition-Metal-Free Access to Heteroaromatic-Fused 4-Tetralones by the Oxidative Ring Expansion of the Cyclobutanol Moiety.
in The Journal of organic chemistry
Natho P
(2018)
Regioselective Transition-Metal-Free Oxidative Cyclobutanol Ring Expansion to 4-Tetralones.
in Organic letters
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509486/1 | 01/10/2016 | 31/03/2022 | |||
| 1974973 | Studentship | EP/N509486/1 | 01/10/2017 | 30/06/2021 | Philipp Natho |
| Description | Novel reactivity in the area of organic synthesis has been discovered. This new methodology allows the transition-metal-free and shorter (and therefore cheaper) construction of molecules with significant biological relavance for the application in drug discovery as memory enhancing agents or antibiotics. |
| Exploitation Route | The outcomes of this research have been published in a variety of articles and further publications are in progress. This allows future group members (and the wider scientific community) to use this methodology to synthesise further biologically active molecules and new undisclosed molecular space for drug discovery. |
| Sectors | Agriculture, Food and Drink,Chemicals,Education,Pharmaceuticals and Medical Biotechnology |
| URL | https://pubs.acs.org/doi/10.1021/acs.joc.9b01290 |