Molecular and genetic dissection of the cytosolic ADP-Heptose-ALPK1-TIFA signaling pathway

Lead Research Organisation: University of Dundee
Department Name: School of Life Sciences


The aim of the project is to dissect the molecular details of the cytosolic ADP-DD-Heptose-ALPK1-TIFA signaling pathway. The initial goals are to understand the essential ubiquitin-independent role of TAB2 and/or TAB3 in the activation of TAK1, the 'master' protein kinase of the pathway and how it is controlled by TRAF6. This unknown mechanism may involve novel components of the pathway that I aim to identify, and which may lead to the discovery a "TIFAsome" and/or other substrates of ALPK1.


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