Periplasmic amidases in bacterial cell division.

Lead Research Organisation: University of Warwick
Department Name: School of Life Sciences

Abstract

During division, bacteria must break and rebuild the peptidoglycan wall that envelopes their cytoplasmic membrane to enable segregation of daughter cells.
In E. coli, the enzymes responsible for breaking peptidoglycan during division are periplasmic amidases that are regulated by a specialised ABC transporter-like protein (FtsEX) and its cognate adaptor protein (EnvC).
This project will address the regulation of periplasmic amidases associated with petidoglycan remodelling using a combination of X-ray crystallography and microbiological techniques. The key question to be answered is how periplasmic amidases interact with, and are activated by, FtsEX-EnvC.
The project aims to provide deep molecular understanding of amidase activity during bacterial cell division that may be useful in developing future antibacterial agents.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
2097254 Studentship BB/M01116X/1 01/10/2018 30/09/2022 Tyler Charles Baverstock