Using a combined approach of molecular microbiology, genomic mining and phylogenomics to discover and activate cryptic biosynthetic gene clusters in S

Lead Research Organisation: University of Warwick
Department Name: School of Life Sciences

Abstract

Actinobacteria are a type of soil bacteria and are a rich source of novel antimicrobials. Streptomyces is the largest group of bacteria in Actinobacteria and possess a number of discovered, undiscovered and putative cryptic gene clusters. Advances in deep sequencing technology, molecular cloning techniques and data mining has allowed the prediction of novel gene pathways through analysis and manipulation of regulatory factors in biosynthetic operons. This project will utilise a combined approach to target various soils to recover intact biosynthetic gene clusters and stimulate the expression of their cryptic products. Such processes will hopefully result in the discovery of novel natural compounds such as antibiotics and anticancer drugs.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
BB/M01116X/1 01/10/2015 30/09/2023
2097313 Studentship BB/M01116X/1 01/10/2018 30/09/2022 Matthew Harwood