Next generation polyfunctional probes for chemical biology

Lead Research Organisation: Imperial College London
Department Name: Dept of Chemistry

Abstract

Recent innovations in chemical probe design and synthesis offer radically new paradigms to control protein function in space and time, extending far beyond the traditional model of 'one drug one protein' inhibitors. Discoveries in protein homeostasis and bioconjugation chemistry have led to probes which can directly modify proteins in living systems, alter protein stability or localisation, and modulate drug targets without the requirement for biochemical inhibition.

This project is a collaboration between scientists at Imperial, GSK and Cellzome, internationally leading groups in the field of chemical probes and protein modification. The aim is to design, synthesise and apply new polyfunctional probes with the capacity to modulate drug targets with exquisite spatiotemporal precision, exploiting photoactivated switching and conjugation, in-cell probe assembly, and multivalent ligands which can 'rewire' protein complexes to generate novel functions from pre-existing cellular components.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/R512540/1 01/10/2017 30/09/2021
2100261 Studentship EP/R512540/1 01/10/2017 30/09/2021 Cyrille Stephane Kounde