Molecular basis of muscle alteration in response to spaceflight

Lead Research Organisation: University of Nottingham
Department Name: School of Medicine

Abstract

Responsible for assisting the execution of the European Space Agency spaceflight experiment Molecular Muscle as well as conducting ground based studies examining the potential of novel compounds for improving muscle health. If compounds are identified these will form the basis of future spaceflight experiment proposals.

Publications

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Sudevan S (2019) Mitochondrial dysfunction causes Ca overload and ECM degradation-mediated muscle damage in . in FASEB journal : official publication of the Federation of American Societies for Experimental Biology

 
Description REXUS/BEXUS Cycle 12
Amount € 200 (EUR)
Organisation ESA - ESTEC 
Sector Public
Country Netherlands
Start 11/2018 
End 12/2018
 
Description REXUS/BEXUS Cycle 13
Amount € 200 (EUR)
Organisation ESA - ESTEC 
Sector Public
Country Netherlands
Start 11/2019 
End 12/2019
 
Title Nemalife 
Description We have developed a device for automated analysis of C. elegans lifespan. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact We have used the nemalife in combination with the nemaflex to discover a new drug that delays muscle force decline with age in worms. The device is available for purchase. 
 
Description BAMMsat-on-BEXUS 
Organisation Cranfield University
Country United Kingdom 
Sector Academic/University 
PI Contribution The BEXUS project allows students to fly hardware in a stratospheric balloon flight. I am responsible for implementing the biological payload in a device to test its readiness for a balloon flight. I will assess the health of the payload and determine if the device is capable of maintaining the health of the payload.
Collaborator Contribution BEXUS is a ESA lead project with collaborators German Aerospace Center (DLR), Swedish National Space Agency (SNSA), Esrange Space Center (SSC) Center of Applied Space Technology and Microgravity (ZARM) and EuroLauch. The project allows students to fly hardware in a stratospheric balloon flight. The team at Cranfield University is designing a device to house a biological payload in space and is using this flight to increase the flight readiness level of the hardware to allow for future space flight. the hardware is being designed and assembled using Cranfield Universities facilities and ESA and collaborators are helping with the design phase, funding and managing the flight and travel. Both Cranfield University and UK Space Agency are contributing funds for manufacturing the hardware.
Impact Currently there are no outputs
Start Year 2018
 
Description BAMMsat-on-BEXUS 
Organisation European Space Agency
Country France 
Sector Public 
PI Contribution The BEXUS project allows students to fly hardware in a stratospheric balloon flight. I am responsible for implementing the biological payload in a device to test its readiness for a balloon flight. I will assess the health of the payload and determine if the device is capable of maintaining the health of the payload.
Collaborator Contribution BEXUS is a ESA lead project with collaborators German Aerospace Center (DLR), Swedish National Space Agency (SNSA), Esrange Space Center (SSC) Center of Applied Space Technology and Microgravity (ZARM) and EuroLauch. The project allows students to fly hardware in a stratospheric balloon flight. The team at Cranfield University is designing a device to house a biological payload in space and is using this flight to increase the flight readiness level of the hardware to allow for future space flight. the hardware is being designed and assembled using Cranfield Universities facilities and ESA and collaborators are helping with the design phase, funding and managing the flight and travel. Both Cranfield University and UK Space Agency are contributing funds for manufacturing the hardware.
Impact Currently there are no outputs
Start Year 2018
 
Description BAMMsat-on-BEXUS 
Organisation UK Space Agency
Country United Kingdom 
Sector Public 
PI Contribution The BEXUS project allows students to fly hardware in a stratospheric balloon flight. I am responsible for implementing the biological payload in a device to test its readiness for a balloon flight. I will assess the health of the payload and determine if the device is capable of maintaining the health of the payload.
Collaborator Contribution BEXUS is a ESA lead project with collaborators German Aerospace Center (DLR), Swedish National Space Agency (SNSA), Esrange Space Center (SSC) Center of Applied Space Technology and Microgravity (ZARM) and EuroLauch. The project allows students to fly hardware in a stratospheric balloon flight. The team at Cranfield University is designing a device to house a biological payload in space and is using this flight to increase the flight readiness level of the hardware to allow for future space flight. the hardware is being designed and assembled using Cranfield Universities facilities and ESA and collaborators are helping with the design phase, funding and managing the flight and travel. Both Cranfield University and UK Space Agency are contributing funds for manufacturing the hardware.
Impact Currently there are no outputs
Start Year 2018
 
Description 5th World Congress on Hydrogen Sulfide in Biology & Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a poster on the project, resulted in discussions and potential collaborations
Year(s) Of Engagement Activity 2018
URL https://www.farmacologiaicbusp.com.br/en/5th-world-congress-on-hydrogen-sulfide-in-biology-and-medic...
 
Description Big Bang Fair South West 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Attended Big Bang South West and interacted with roughly 6000 people, mostly primary and secondary school students. Activities included looking at normal and mutant worms, handling spaceflight hardware, and talking about science and spaceflight. Students and teachers were both enthusiastic with requests for school visits and expressions of interest in pursuing careers in science and engineering.
Year(s) Of Engagement Activity 2019
 
Description Experimental models in physiology - Physiological Society Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presented a poster
Year(s) Of Engagement Activity 2018
 
Description Mitochondrial Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk
Year(s) Of Engagement Activity 2019
URL https://coursesandconferences.wellcomegenomecampus.org/our-events/mitochondrial-medicine-2019/
 
Description REXUS/BEXUS workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation to determine place on project. Place on project and funding was awarded.
Year(s) Of Engagement Activity 2019
URL http://www.rexusbexus.net/
 
Description REXUS/BEXUS workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation to determine place on BEXUS project. Outcome was unsuccessful and place/funding was denied.
Year(s) Of Engagement Activity 2018
 
Description Space Day 2019 (British interplanetary society) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Did an interactive display of normal and simulated spaceflight worms and discussed how we do space biology with the public at an event hosted by the British Interplanetary Society. Audience reported they were not fully aware of the UK space agency or what went into a space biology experiment.
Year(s) Of Engagement Activity 2019
 
Description UK worm meeting 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of a poster.
Year(s) Of Engagement Activity 2019
 
Description Wonder (University of Nottingham) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Attended Wonder hosted by the University of Nottingham. Activities included looking at normal and mutant worms, handling spaceflight hardware, and talking about science and spaceflight.
Year(s) Of Engagement Activity 2019
URL https://www.nottingham.ac.uk/wonder/