Cationic Polymers for Gene Delivery

Lead Research Organisation: Imperial College London
Department Name: Materials

Abstract

Cationic polymers provide a safer alternative to viral vectors that have the disadvantage of causing immune response. Specifically, positively charged polymers have the ability to bind the negatively charged genetic material, hence creating a neutral or slightly positively charged polymer / DNA complex that can pass through the hydrophobic and negatively charged cellular membrane. Thus, the gene is delivered into the cell.
The aim of this thesis will be to identify important design criteria. Thus well-defined cationic polymers of different architectures, compositions and molar masses will be synthesised and systematically investigated in terms of their ability to delivery genetic material.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509486/1 01/10/2016 30/09/2021
2132101 Studentship EP/N509486/1 29/09/2018 31/03/2022 Joana Salvado Cortico De Sousa Correia
EP/R513052/1 01/10/2018 30/09/2023
2132101 Studentship EP/R513052/1 29/09/2018 31/03/2022 Joana Salvado Cortico De Sousa Correia