Validation of uptake, heterogeneity and shape metrics in clinical PET-CT using Monte Carlo Simulation and 3D printed anthropomorphic phantoms

Lead Research Organisation: University of Manchester
Department Name: Physics and Astronomy

Abstract

This project aims to establish the current uncertainty in estimating the therapeutic radiation dose delivered to tumours in Molecular RadioTherapy (MRT) and to evaluate methods for improving the accuracy of estimation. This knowledge will contribute to a better understanding of the clinical effectiveness of MRT and to better patient management in Oncology. The research will utilise data from Single Photon Emission Computed Tomography (SPECT) clinical imaging and will employ patient specific 3D printed phantoms and Monte-Carlo (MC) simulations.

Publications

10 25 50

Studentship Projects

Project Reference Relationship Related To Start End Student Name
ST/R005540/1 01/10/2018 30/09/2022
2224212 Studentship ST/R005540/1 20/09/2018 31/03/2022 George Richard Needham
 
Title 3D-Printed Tumour Phantoms 
Description A series of 3D-printed anthropomorphic tumour phantoms modelled on data from patient PET scans. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? No  
Impact Produced to validate GATE simulations of the same geometry. The use of these non-standard geometries forms the final part of an experiment in using scans of a known activity distribution at a range of different activities to form a study into reproducibility of PET heterogeneity metrics. 
 
Title GATE Simulation for the Siemens Biograph mCT PET scanner 
Description Series of GATE (Geant4 Application for Emission Tomography) simulation macros for the Siemens Biograph mCT PET scanner. Macros designed for ease of use with HTCondor cluster computing. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? No  
Impact This is a scanner previously not properly integrated in GATE literature due to the complex nature of the image reconstruction behind it (Siemens' 'virtual crystals'). 
 
Description The Christie NHS Foundation Trust Nuclear Medicine Research 
Organisation The Christie NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Academic expertise, computational facilities for simulation work, 3D printing facilities, academic writing and reporting
Collaborator Contribution Providing the use of PET scanning facilities, 3D printing facilities, professional and academic expertise
Impact Collaboration unites The Christie's clinical experience and applications with the University's academic nuclear physics background.
Start Year 2018
 
Description IFAMP Radiomics Summer School 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Three-day program of workshops and seminars on the current state of radiomics in theory and application. Useful discussions had with industry professionals on several occasions which have been incredibly useful for my future work.
Year(s) Of Engagement Activity 2020
URL https://ifamp.eu/course1-online.html
 
Description Open Day at The Christie NHS Foundation Trust in support of International Day of Medical Physics 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Operated a stand on site at The Christie NHS Foundation Trust demonstrating public engagement tools developed by the collaboration, with the purpose of informing the general public and fellow staff at The Christie about the work undertaken by both the department and the collaboration. Tools included a miniature model of a SPECT scanner with rotating heads that could be used to explain the mechanics of its operation. Visitors included staff, patients at The Christie and other people on site on the day. All visitors left interested and grateful for insight provided as well as entertained by the content of the stand.
Year(s) Of Engagement Activity 2019
 
Description STFC Data Intensive, Artificial Intelligence & Machine Learning Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Summer school with a week-long program of data and machine-learning based seminars, practical sessions, careers workshops, networking events. Formed connections and gained experience with tools that have both helped with my research.
Year(s) Of Engagement Activity 2019
URL https://www.sussex.ac.uk/discus/contact/stfcsummerschool2019
 
Description Seminars given to the Nuclear Physics Group at The University of Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Annual 15-25 minute seminar given to the Nuclear Physics Group at the University of Manchester as part of the Student Seminar series. Usual attendance of between 10 and 20 postgraduate students, postdoctoral research staff and academics. Followed by a questions and discussion section which has been useful for disseminating information about the work done not only in the collaboration but also about the wider field of nuclear medicine.
Year(s) Of Engagement Activity 2019,2020,2021
 
Description Talk for the 27th Software Meeting of CCP/SyneRBI about STIR implementation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave a talk to the CCP/SyneRBI collaboration for their 27th Software Meeting, which formed the opening session to a software hackathon for STIR (the open-source PET image reconstruction software developed by members of the collaboration). Aim was to provide information about how STIR could be used in practice and how I would like STIR to be developed for use within my own work, specifically around the implementation of Siemens' 'virtual crystals'. Resulted in a topic of focus for the week-long hackathon in an effort to fix this issue. Progress was made although still not fully integrable into my work.
Year(s) Of Engagement Activity 2020
URL http://www.ccpsynerbi.ac.uk/node/272
 
Description Talk to University of Manchester Nuclear & Particle Physics Society (NPPS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Twenty-minute talk to undergraduate students about the work done as part of the collaboration between The University of Manchester & the Nuclear Medicine department at The Christie NHS Foundation Trust; appeared as one of three invited speakers along with Sophia Pells of this collaboration & Dr Heather Williams from The Christie. Presentation given remotely to around 30 student members, and video recording shared through the Society's private Facebook page for those who were unable to attend. Questions surrounded interest in accessing postgraduate research as a career option and how one gets into applied sciences.
Year(s) Of Engagement Activity 2020
 
Description UCL MedICSS Summer School 2019 (including Poster Presentation of my work) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 48 postgraduate students and industry professionals attended the UCL-hosted Medical Image Computing Summer School (MedICSS). This began with a networking event and poster session where each delegate presented their work to each other and interested host academics. This developed interest in this project through discussion of my work. Following days included a scheduled program of fascinating seminars and workshops around the cutting edge of machine learning in medical image processing and patient-specific treatments.
Year(s) Of Engagement Activity 2019
URL https://medicss.cs.ucl.ac.uk/programme-2019/