Mechanics-guided differentiation in embryonic tissue ex vivo
Lead Research Organisation:
UNIVERSITY COLLEGE LONDON
Department Name: Cell and Developmental Biology
Abstract
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Organisations
People |
ORCID iD |
| Geraint Thomas (Primary Supervisor) | |
| Matyas Bubna-Litic (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M009513/1 | 30/09/2015 | 31/03/2024 | |||
| 2241747 | Studentship | BB/M009513/1 | 30/09/2019 | 29/02/2024 | Matyas Bubna-Litic |
| NE/W502716/1 | 31/03/2021 | 30/03/2022 | |||
| 2241747 | Studentship | NE/W502716/1 | 30/09/2019 | 29/02/2024 | Matyas Bubna-Litic |
| Description | The project has set out to study the effects of manipulation of cell mechanics on the development of vertebrate embryos and several observations were made that suggest an involvement of mechanico-chemical signaling in key morphogenetic movements and signalling in the early Xenopus embryo. These observations might support the further development of organoid systems in other species which may effect the success of this technology in diagnostic and therapeutic settings. |
| Exploitation Route | The outcomes of this project may be used to generate new hypotheses about embryonic development and the role of mechanics in specifying cell fate and/or cell behaviour. Furthermore, the experimental tools used have been developed or adapted to work in the Xenopus system and may be useful for other researchers using this system. |
| Sectors | Pharmaceuticals and Medical Biotechnology |