Transdermal Insulin on Demand

Lead Research Organisation: University of Nottingham
Department Name: Sch of Pharmacy

Abstract

The projects goal is to design and develop a device for transdermal pain free delivery of insulin using a combination of microneedle conduits/channels and other drug delivery technologies. The clinical need for such a device is the poor compliance of the insulin injections currently by diabetics leading to poor control of glucose levels. This can lead to blindness, kidney failure, heart attacks, stroke and lower limb amputation. Hence this project sets out to design and develop a device based on microneedles that can breach the stratum corneum and act as a continuous drug delivery conduit to the skin surface where a drug reservoir will be located. Consequently, it will allow the delivery of appropriate miilligram doses of insulin. The project will use the unique capabilities in precision manufacturing and additive manufacturing techniques for the rapid prototyping of devices. Dr Marlow's group have recently developed novel hydrogel forming microneedles for the delivery of imiquimod for the treatment of basal cell carcinoma and this maybe considered as one of the design options amongst others such as a permanent microneedle 'sheath' to maintain the conduit with or without micromachined 'microvalves'. Hydrogel forming needles if used will be manufactured by spin-casting polymer solutions onto PDMS moulds utilizing centrifugation. The mechanical strength and skin insertion of the device will be characterised along with in vitro assessment of transdermal delivery of insulin using a Franz cell. Upon completion of in vitro assessments, devices will be progressed to in vivo studies in a suitable animal model, such as rat or mini pig.

Project aligned to Advanced Product Design

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/S023054/1 01/10/2019 31/03/2028
2283837 Studentship EP/S023054/1 01/10/2019 30/09/2023 Fiona Marie Smith