In vitro microfluidic models of microvasculature for understanding of disease and injury

Many conditions which affect the human circulatory system are caused by complications in the flow within capillaries in tissue. This particularly an issue following trauma, where collapse of the microvasculature in a tissue compartment can cause necrosis (death) requiring surgery or amputation. This project will focus on the development of microfluidic models in the laboratory, which will be interrogated to develop new approaches for diagnosis and treatment.