Key Findings
three-dimensional differentiated airway epithelial cell model at air-liquid interface (ALI) of the...
Collaboration
Structural biology and molecular genetics of IFT80
Collaboration
Structural biology and molecular genetics of IFT80
Collaboration
Dr Dominic Norris, Polycystin-2 cilia mechnobiology
Further Funding
CEP41 in autism spectrum disorder using human cortical organoids
Collaboration
molecular organization of the ciliary transition zone
Collaboration
molecular organization of the ciliary transition zone
Research Databases and Models
Supplementary material 1: Whole mount stain of a 72hr infected Nasal epithelial culture with...
Impact Summary
2016 (part of European Researchers' Night), held at the Glasgow Science Center, in September 2016...
Collaboration
structural biology of ciliary proteins
Collaboration
structural biology of ciliary proteins
Key Findings
cognitive functions unique to humans. In order to function properly, the cortex requires a large...
Research Databases and Models
Research Databases and Models
Further Funding
transport within cilia and flagella
Further Funding
regulates chondrocyte response to inflammatory cytokines
Further Funding
transport within cilia and flagella
Impact Summary
understanding of the role of cilia related genes in male infertility and the unknown function of...
Collaboration
COST Action BEAT-PCD
Further Funding
structure and function (PhD Studentship)
Key Findings
in which the dynein-2 microtubule motor works in the formation and function of primary cilia. This...
Key Findings
years research works we now can confirm that planar cell polarity is important in the skin,...
Key Findings
postulated through analysis of TALPID3 homologues that TALPID3 has a Eumetazoan origin
TALPID3 has...
Products Interventions & Clinical Trials
Cilia are small structures that protrude from the surface of most animal cells like antennae. Like...
Products Interventions & Clinical Trials
Cilia are small structures that protrude from the surface of most animal cells like antennae. Like...
Collaboration
Nordic Centrosome and Cilia Network
Key Findings
facility not a s[pecific project: Vaughan: 3-D organisation of the flagellar pocket in T....
Further Funding
Quidwai, Title: WDR35/ IFT121 functions like COPI vesicles to transport cilia specific cargo to...
Key Findings
functions such as mucociliary clearance in our airways and for sperm to swim. The molecular motors...
Research Databases and Models
Paranasal sinuses are hollow spaces within the bones surrounding the nose. Of these, the largest...
Key Findings
series of genetics interactions between key proteins in the primary cilium, the sensory...
Key Findings
mechanism by which neighbouring cilia and flagella synchronise their beating. These whip-like...
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Frankfurt/Cologne clinical genetics
Collaboration
Role of IFT-A in ciliary trafficking
Collaboration
Role of IFT-A in ciliary trafficking
Research Tools and Methods
We have used traditional paraformaldehyde fixation and histological staining combined with confocal...
Key Findings
provide a detailed three dimensional view of the connections between basal bodies in the parasite...
Key Findings
sperm cells interact with their fluid environment and surrounding walls. Sperm are tiny swimming...
Key Findings
and biogenesis of connections between basal bodies was carried out and this manuscript is now in...
Collaboration
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei.
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Tools and Methods
1) list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
Role of primary cilia in cortical development
Collaboration
UK Cilia Network
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Research Databases and Models
High content siRNA screen carried out to identify genes which when knocked-down, cause the...
Collaboration
Finnish PCD genetics
Collaboration
Analysis of cilia development and patterning
Key Findings
reconstruction of the beating swimming appendages (flagella) of Chlamydomonas algae. This is an...
Collaboration
Analysis of rho kinase inhibitors of ciliary function
Collaboration
Cryo-EM structure of cilia
Collaboration
Cryo-EM structure of cilia
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
functional characterization of ciliopathy proteins
Collaboration
Collaboration with molecular basis of disease and therapeutics
Research Tools and Methods
We generted a number of transgenic lines (>10) to manipulate phosphoinositide content in cilia.
Key Findings
award:
1. We have produced single cell sequencing data to generate a single cell atlas of the...
Key Findings
cilia to be resorbed and identified the pathway responsible
Collaboration
From Astronomy to detecting Respiratory Cilia cells
Collaboration
PCD male fertility assessment
Key Findings
spectrum of symptoms, but have in common that they all lead to impaired cilia formation or...
Key Findings
model organism to examine signalling processes in flagella. We identified how the movement of...
Impact Summary
cytoplasmic dynein-2 molecular motor in humans. This has also led to the identification of a...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Research Databases and Models
list of validated candidate genes implicated in ciliogenesis, cilia maintenance and cilia length...
Collaboration
Functional Conservation in Ciliary Trafficking
Key Findings
surface of almost every cell type in the body. They are critical for human physiology, as they they...
Collaboration
Analysis of primary cilia in human cells
Key Findings
and Dchs1 mouse mutants. Cilia are parts of cells needed for movement of brain and spinal fluid....